Biophysics Books

Book SynopsisFluid dynamics plays a crucial role in many cellular processes, including the locomotion of cells such as bacteria and spermatozoa. These organisms possess flagella, slender organelles whose time periodic motion in a fluid environment gives rise to motility. Sitting at the intersection of applied mathematics, physics and biology, the fluid dynamics of cell motility is one of the most successful applications of mathematical tools to the understanding of the biological world. Based on courses taught over several years, it details the mathematical modelling necessary to understand cell motility in fluids, covering phenomena ranging from single-cell motion to instabilities in cell populations. Each chapter introduces mathematical models to rationalise experiments, uses physical intuition to interpret mathematical results, highlights the history of the field and discusses notable current research questions. All mathematical derivations are included for students new to the field, and end-of-Table of ContentsPart I. Fundamentals: 1. Biological background; 2. The fluid dynamics of microscopic locomotion; 3. The waving sheet model; 4. The squirmer model; Part II. Cellular locomotion: 5. Flagella and the physics of viscous propulsion; 6. Hydrodynamics of slender filaments; 7. Waving of eukaryotic flagella; 8. Rotation of bacterial flagellar filaments; 9. Flows and stresses induced by cells; Part III. Interactions: 10. Swimming cells in flows; 11. Self-propulsion and surfaces; 12. Hydrodynamic synchronisation; 13. Diffusion and noisy swimming; 14. Hydrodynamics of collective locomotion; 15. Locomotion and transport in complex fluids; References; Index.

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Book SynopsisDiscover the fundamental principles of biomedical measurement design and performance evaluation with this hands-on guide. Whether you develop measurement instruments or use them in novel ways, this practical text will prepare you to be an effective generator and consumer of biomedical data. Designed for both classroom instruction and self-study, it explains how information is encoded into recorded data and can be extracted and displayed in an accessible manner. Describes and integrates experimental design, performance assessment, classification, and system modelling. Combines mathematical concepts with computational models, providing the tools needed to answer advanced biomedical questions. Includes MATLAB scripts throughout to help readers model all types of biomedical systems, and contains numerous homework problems, with a solutions manual available online. This is an essential text for advanced undergraduate and graduate students in bioengineering, electrical and computer engineeriTrade Review'a good introductory text on the technical aspects of analyzing measured data sets for graduate students or advanced undergraduates in a premedical or related curriculum … In an increasingly crowded publication space, this book offers something new and valuable, making implementation of data analysis approaches accessible for biomedical scientists and the engineers who work with them … Highly recommended.' M. R. King, Choice ConnectTable of Contents1. Introduction to measurement systems; 2. Probability; 3. Statistics of random processes; 4. Spatiotemporal models of the measurement process; 5. Basis decomposition I; 6. Basis decomposition II; 7. Projection radiography; 8. Statistical decision-making; 9. Statistical pattern recognition with flow cytometry examples; 10. ODE models I, biological systems; 11. ODE models II, sensors.

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Book SynopsisDeals with the major terrestrial, algal, and siliceous indicators used in paleolimnology. This title is of interest to seasoned practitioners as well as newcomers to the area of paleolimnology.Trade Review"Volume 3 will be of particular interest to paleolimnologists approaching the subject from the biological or limnological standpoint; some of the most important indicators used by paleolimnologists including pollen analysis, plant macrofossils, charcoal, diatoms, chrysophytes, phytoliths, biogenic silica and pigments. These chapters will become essential citations in the methods sections of future papers." (Philip Barker, Dept. of Geography, Institute of Environmental and Natural Sciences, Lancaster University, UK in Journal of Paleolimnology, 30:4)Table of ContentsPreface. The Editors. Aims & Scope of Developments in Paleoenvironmental Research Book Series. Editors and Board of Advisors of Developments in Paleoenvironmental Research Book Series. Contents of Volumes 1 to 4. Safety Considerations and Caution. Dedication. List of Contributors. 1. Using biology to study long-term environmental change; J.P. Smol, et al. 2. Pollen; K.D. Bennett, K.J. Willis. 3. Conifer stomata; G.M. MacDonald. 4. Plant macrofossils; H.H. Birks. 5. Charcoal as a fire proxy; C. Whitlock, C.P.S. Larsen. 6. Non-pollen palynomorphs; B. van Geel. 7. Protozoa: testate amoebae; L. Beyens, R. Meisterfeld. 8. Diatoms; R.W. Battarbee, et al. 9. Chrysophyte scales and cysts; B.A. Zeeb, J.P. Smol. 10. Ebridians; A. Korhola, J.P. Smol. 11. Phytoliths; D.R. Piperno. 12. Freshwater sponges; T.M. Frost. 13. Siliceous protozoan plates and scales; M.S.V. Douglas, J.P. Smol. 14. Biogenic silica; D.J. Conley, C.L. Schelske. 15. Sedimentary pigments; P.R. Leavitt, D.A. Hodgson. Glossary, Acronyms and Abbreviations. Subject Index.

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Book SynopsisPrinciples of Biophysical Inquiry.- Introduction: To the Student First Edition.- Philosophy and Practice of Biophysical Study.- Overview of the Biological System Under Study.- Physical Thoughts, Biological Systems The Application of Modeling Principles to Understanding Biological Systems.- Probability and Statistics.- Foundations.- Energy and Force The Prime Observables.- Biophysical Forces in Molecular Systems.- Physical Principles: Quantum Mechanics.- Chemical Principles.- Measuring the Energy of a System: Energetics and the First Law of Thermodynamics.- Entropy and the Second Law of Thermodynamics.- Which Way Is That System Going? The Gibbs Free Energy.- The Thermodynamics of Phase Equilibria.- Building a Model of Biomolecular Structure.- Water: A Unique Solvent and Vital Component of Life.- IonSolvent Interactions.- IonIon Interactions.- Lipids in Aqueous Solution.- Macromolecules in Solution.- Molecular Modeling Mapping Biochemical State Space.- The Electrified Interphase.- Function and Action Biological State Space.- Transport A Non-equilibrium Process.- Flow in a Chemical Potential Field: Diffusion.- Flow in an Electric Field: Conduction.- Forces Across Membranes.- Kinetics Chemical Kinetics.- Dynamic Bioelectrochemistry Charge Transfer in Biological Systems.- Methods for the Measuring Structure and Function.- Separation and Characterization of Biomolecules Based on Macroscopic Properties.- Analysis of Molecular Structure with Electronic Spectroscopy.- Molecular Structure from Scattering Phenomena.- Analysis of Structure Microscopy.- Epilogue.- Physical Constants.Table of ContentsPREFACE PART I: Principles of Biophysical Inquiry Chapter 1 Introduction: “To the Student” Chapter 2 Philosophy and Practice of Biophysical Study Chapter 3 Overview of the Biological System Under Study – Descriptive Models Chapter 4 Physical Thoughts, Biological Systems - The application of modeling principles to understanding biological systems Chapter 5 Probability and Statistics PART II: Foundations Chapter 6 Physical Principles: Energy - The Prime Observable Chapter 7 Biophysical Forces in Molecular Systems Chapter 8 An Introduction to Quantum Mechanics Chapter 9 Chemical Principles Chapter 10 Measuring the Energy of a System: Energetics and the First Law of Thermodynamics Chapter 11 Entropy and the Second Law of Thermodynamics Chapter 12 Which Way Did That System Go? The Gibbs Free Energy Chapter 13 The Thermodynamics of Phase Equilibria PART III: Building a Model of Biomolecular Structure Chapter 14 Water: A Unique Structure, A Unique Solvent Chapter 15 Ion-Solvent Interactions Chapter 16 Ion-Ion Interactions Chapter 17 Lipids in Aqueous Solution Chapter 18 Macromolecules in Solution Chapter 19 Molecular Modeling - Mapping Biochemical State Space Chapter 20 The Electrified Interphase PART IV: Function and Action Biological State Space Chapter 21 Transport and Kinetics: Processes Not at Equilibrium Chapter 22 Flow in a Chemical Potential Field: Diffusion Chapter 23 Flow in an Electrical Field: Conduction Chapter 24 Forces Across Membranes Chapter 25 Kinetics - Chemical Kinetics Chapter 26 Bioelectrochemistry – Charge Transfer in Biological Systems PART V: Methods for the Measuring Structure and Function Chapter 27 Separation and Characterization of Biomolecules Based on Macroscopic Properties (with Kristin E. Bergethon) Chapter 28 Determining Structure by molecular interactions with photons: Electronic Spectroscopy (with Kristin Bergethon) Chapter 29 Determining Structure by molecular interactions with photons: ScatteringPhenomena Chapter 30 Analysis of Structure – Microscopy Chapter 31 Epilogue Chapter 32 Physical Constants PART VI: APPENDICES Appendix A Review of Mathematical Methods Appendix B Quantum Electrodynamics Appendix C The Pre-Socratic Roots of Modern Science Appendix D The Poisson Function Appendix E Assumptions of a Kinetic Theory of Ideal Gas Behavior Appendix F Determination of a Field from the Potential Appendix G Geometric Optics Appendix H The Compton Effect Appendix I Hamilton's Principle of Least Action/Fermat's Principle of Least Time Appendix J Energy of Interaction between ions Appendix K Derivation of the Statement, Qrev > Qirrev Appendix L Derivation of the Clausius-Clapeyron Equation Appendix M Derivation of the van't Hoff Equation for Osmotic Pressure Appendix N Pseudoforces Appendix O Work of charging and discharging a rigid sphere Appendix P Review of Electrical Circuits Appendix Q Fermi's Golden Rule Appendix R Adiabatic vs non-Adiabatic processes

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Book SynopsisThis book is based on a series of lectures for a course on ionic channels held in Santiago, Chile, on November 17-20, 1984.Table of ContentsI. Methodologies.- 1 Kinetic Models and Channel Fluctuations.- 1. Introduction.- 2. Two-State Channel.- 3. Two Two-State Channels.- 4. Three-State Channel with Three Conductances.- 5. Three-State Channel with Only Two Conductances.- References.- 2 Single-Channel Currents and Postsynaptic Drug Actions.- 1. Introduction.- 2. Channel Gating as a Stochastic Process.- 3. Postsynaptic Channels in the Presence of Drugs.- 4. Reconstructing the Postsynaptic Current.- 5. Macroscopic and Molecular Consequences.- References.- 3 Voltage-Dependent Gating: Gating Current Measurement and Interpretation.- 1. Introduction.- 2. Voltage Gating.- 3. Gating Current Is a Capacitive Current.- 4. Measurement of Gating Currents.- 5. Gating of the Sodium Channel.- References.- 4 Characterizing the Electrical Behavior of an Open Channel via the Energy Profile for Ion Permeation: A Prototype Using a Fluctuating Barrier Model for the Acetylcholine Receptor Channel.- 1. Introduction.- 2. Theory.- 3. Confrontation with Experimental Data for the AChR Channel.- 4. Discussion.- References.- 5 The Use of Specific Ligands to Study Sodium Channels in Muscle.- 1. Introduction.- 2. Molecular Pharmacology of the Sodium Channel in Muscle.- 3. Sodium Channel in Cardiac Muscle: Are All Sodium Channels Alike?.- 4. Surface and Tubular Sodium Channels in Skeletal Muscle.- 5. Models for Sodium Channels in Muscle Membranes.- References.- 6 Isolation of Muscle Membranes Containing Functional Ionic Channels.- 1. Introduction.- 2. Excitation-Contraction Coupling.- 3. Ionic Channels and E-C Coupling.- 4. Isolation of Muscle Membranes.- 5. Concluding Remarks.- References.- 7 Methodologies to Study Channel-Mediated Ion Fluxes in Membrane Vesicles.- 1. Introduction.- 2. Channel-Mediated Tl+ Flux Measured by Fluorescence Quenching.- 3. Channel-Mediated Ion Fluxes Measured by Light Scattering.- References.- 8 Optical Studies on Ionic Channels in Intact Vertebrate Nerve Terminals.- 1. Introduction.- 2. Equivalence of Optical and Electrical Measurements of Membrane Potential.- 3. Optical Recording of Action Potentials from Nerve Terminals of the Frog Xenopus.- 4. Properties of the Action Potential in the Nerve Terminals.- 5. Ionic Basis of the Depolarizing Phase of the Action Potential.- 6. Concluding Remarks.- References.- 9 Optical Detection of ATP Release from Stimulated Endocrine Cells: A Universal Marker of Exocytotic Secretion of Hormones.- 1. Introduction.- 2. Methodological Considerations.- 3. Acetylcholine-Induced ATP Release from Chromaffin Cells: Calcium Dependence.- 4. Nicotinic Receptor Desensitization.- 5. Granular Nature of the Secreted ATP.- 6. ATP Release Evoked by Membrane Depolarization Is Mediated by Activation of Voltage-Gated Calcium Channels.- 7. ATP Release from Collagenase-Isolated Islets of Langerhans.- 8. Conclusion.- 9. Summary.- References.- II. Channels in Biological Membranes.- 10 Mechanotransducing Ion Channels.- 1. Introduction.- 2. Recording SA Channels.- 3. General Characteristics.- 4. Conductance Properties.- 5. Kinetic Properties.- 6. The Model.- 7. Comparing the Model to the Data.- 8. Future Prospects.- References.- 11 Ionic Channels in Plant Protoplasts.- 1. Introduction.- 2. Some Methodological Considerations.- 3. Voltage-Dependent Channels Opened by Hyperpolarization.- 4. Channels Affected by TEA.- 5. Conclusions.- References.- 12 Channels in Kidney Epithelial Cells.- 1. Introduction.- 2. Cell Culture.- 3. Patch-Clamp Methodology.- 4. Potassium Channel Characteristics.- 5. Channel Modulation.- 6. Conclusions.- References.- 13 Channels in Photoreceptors.- 1. Introduction.- 2. Vertebrate Photoreceptors.- 3. Invertebrate Photoreceptors.- References.- 14 Inactivation of Calcium Currents in Muscle Fibers from Balanus.- 1. Introduction.- 2. Methodological Considerations.- 3. Characteristics of Inward Currents.- 4. Mechanism of Inactivation.- References.- 15 Electrophysiological Studies in Endocrine Cells.- 1. Introduction.- 2. Whole-Cell Patch-Clamp Methodology.- 3. Cell Culture.- 4. Ionic Currents in GH3 Cells.- 5. Characteristics of Calcium Channels.- 6. Conclusions.- References.- III. Ionic Channel Reconstitution.- 16 Ion Channel Reconstitution: Why Bother?.- 1. Introduction and Background.- 2. Unexpected Surprises.- 3. Unconstrained Variables.- 4. Unrealized Hopes.- References.- 17 From Brain to Bilayer: Sodium Channels from Rat Neurons Incorporated into Planar Lipid Membranes.- 1. Perspectives and Background.- 2. Electrophysiology without Cells.- 3. A Closer Look at Batrachotoxin-Activated Sodium Channels in Bilayer Membranes.- 4. Looking Ahead.- References.- 18 Ionic Channels in the Plasma Membrane of Sea Urchin Sperm.- 1. Introduction.- 2. Are There Channels in Sea Urchin Sperm?.- 3. Reconstitution Studies with Isolated Sea Urchin Sperm Plasma Membrane.- 4. Channels in the Plasma Membrane of Sea Urchin Sperm: Implications for the Acrosome Reaction.- 5. Are There Receptors to the Egg Jelly in the Sea Urchin Sperm Plasma Membranes?.- 6. Perspectives.- References.- 19 Characterization of Large-Unitary-Conductance Calcium-Activated Potassium Channels in Planar Lipid Bilayers.- 1. Introduction.- 2. Channel Gating.- 3. Channel Conductance and Selectivity.- 4. Conductance of the Calcium-Activated K+ Channels.- 5. Selectivity of the Ca-K Channels.- 6. Blockade of the Ca-K Channels.- 7. Conclusions.- References.- IV. Ionic Channel Modulation.- 20 Metabolic Regulation of Ion Channels.- 1. Introduction.- 2. Second Messengers.- 3. Protein Phosphorylation.- 4. Summary.- References.- 21 The Cell-to-Cell Membrane Channel: Its Regulation by Cellular Phosphorylation.- 1. Introduction.- 2. The Cell-to-Cell Channels Are Up-Regulated by cAMP-Dependent Phosphorylation.- 3. The Cell-to-Cell Channels are Down-Regulated by Tyrosine Phosphorylation.- References.- 22 The ?-Cell Bursting Pattern and Intracellular Calcium.- 1. Introduction.- 2. Role of [Ca2+]i Dependence on Glucose.- 3. A Biophysical/Mathematical Model.- 4. Burst Frequency Depends on the Ratio [free Ca2+]i/[total Ca]i.- 5. Summary.- References.- 23 Neurotrophic Effects of in Vitro Innervation of Cultured Muscle Cells. Modulation of Ca2+-Activated K+ Conductances.- 1. Introduction.- 2. Methodological Considerations.- 3. Innervation and Muscle Cell Electrical Activity.- 4. Conclusions.- References.- V. Ionic Channel Structure, Functions, and Models.- 24 Correlation of the Molecular Structure with Functional Properties of the Acetylcholine Receptor Protein.- 1. Introduction.- 2. The AChR Macromolecule.- 3. Arrangement of Subunits in the AChR Macromolecule.- 4. The AChR Primary Structure, cDNA Recombinant Techniques, and Modeling Receptor Structure.- 5. Immunochemistry of AChR and the Testing of Models.- 6. Voltage-Gated and Agonist-Gated Channels: A Comparison.- 7. Dynamics of AChR and Lipids in the Membrane.- 8. Acetylcholine-Receptor-Controlled Channel Properties.- References.- 25 Amiloride-Sensitive Epithelial Sodium Channels.- 1. Introduction.- 2. Amiloride-Sensitive Na+ Transport Processes.- 3. Characterization of Amiloride-Sensitive Na+ Channels in Intact Epithelia.- 4. Incorporation of Amiloride-Sensitive Na+ Channels into Planar Bilayers.- 5. Concluding Remarks.- References.- 26 A Channel Model for Development of the Fertilization Membrane in Sea Urchin Eggs.- 1. Introduction.- 2. Processes Following Fertilization.- 3. Experimental Basis for Model.- 4. Description of Model.- 5. Equations of Model.- 6. Solutions of Model Equations.- References.

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Book SynopsisThis richly illustrated third edition provides a thorough training in practical mathematical biology and shows how exciting mathematical challenges can arise from a genuinely interdisciplinary involvement with the biosciences.Trade ReviewFrom the reviews: "The 2nd volume of the authors elucidating work highlights a surprisingly broad spectrum of applications in the field of mathematical biology. The sense given to the mathematical texture of thoughts broadens the reader’s insight … . The growing number of specialists in sub-disciplines of mathematical biology will be enjoying the truly concise approach … . It can so be said that the foremost results … might be essential for new interpretations of data … . It is a recommended text for mathematicians … ." (Daniel Gertsch, Bioworld, Issue 2, 2004) From the reviews of the third edition: "This is the second volume of the third edition of Murray’s ‘Mathematical Biology’. … covers a wide variety of problems in pattern formation, each discussed in its biological context. … This volume alone is a large book, with more than 800 pages and a similar number of references. … it is a valuable collection of results from different areas of mathematical biology." (Carlo Laing, New Zealand Mathematical Society Newsletter, Issue 90, April, 2004) "This book, a classical text in mathematical biology, cleverly combines mathematical tools with subject area sciences. The multi-layer way of material presentation makes the book useful for different types of reader including graduate-level students, bioscientists … . it is an enjoyable reading and I recommend it to anyone with serious interest in mathematical modelling." (V.V. Fedorov, Short Book Reviews, Vol. 23 (3), 2003) "This second volume of the third edition of Murray’s Mathematical biology focuses on partial differential equations (spatial models) and their application to the biomedical sciences. … Each chapter deals with its particular topic in great detail, usually focusing on one biological example and the associated mathematical model and results. This volume is not an introductory text … making it extremely useful in graduate courses and for reference." (Trachette L. Jackson, Mathematical Reviews, 2004b) "In this second volume … the development towards specific biological configurations and towards a mechanism for understanding morphogenesis represents an important portion of the work. … chapters deal with attractive topics … . There is an extensive index at the end. … very interesting and strongly recommended." (A. Akutowicz, Zentralblatt MATH, Vol. 1006, 2003) "In this volume it becomes clear that compiling the third edition was a ‘labor of love’. The book has a significantly different feel from the original first edition. … my reaction to the third edition was positive. … The historical and biological overviews have much interesting information. … Certainly, the spicy writing will keep students alert … . In summary, I recommend the new and expanded third edition to any serious young student interested in mathematical biology … ." (Leah Edelstein-Keshet, SIAM Review, Vol. 46 (1), 2004) "Mathematical Biology would be eminently suitable as a text for a final year undergraduate or postgraduate course in mathematical biology … . It is also a good source of examples for courses in mathematical methods … . Mathematical Biology provides a good way into the field and a useful reference for those of us already there. It may attract more mathematicians to work in biology by showing them that there is real work to be done." (Peter Saunders, The Mathematical Gazette, Vol. 90 (518), 2006)Table of ContentsMulti-Species Waves and Practical Applications * Spatial Pattern Formation with Reaction Diffusion Systems * Animal Coat Patterns and Other Practical Applications of Reaction Diffusion Mechanisms * Pattern Formation on Growing Domains: Alligators and Snakes * Bacterial Patterns and Chemotaxis * Mechanical Theory for Generating Pattern and Form in Development * Evolution, Morphogenetic Laws, Developmental Constraints and Teratologies * A Mechanical Theory of Vascular Network Formation * Epidermal Wound Healing * Dermal Wound Healing * Growth and Control of Brain Tumours * Neural Models of Pattern Formation * Geographic Spread and Control of Epidemics * Wolf Territoriality, Wolf-Deer Interaction and Survival

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Book SynopsisFrom Antiquity to George Corner.- From Antiquity to George Corner.- The Past Five Decades.- Technological Breakthroughs.- Normal Physiology.- Pathophysiology: The Anovulatory Woman.- Therapeutic Developments.Table of ContentsFrom Antiquity to George Corner.- From Antiquity to George Corner.- The Past Five Decades.- Technological Breakthroughs.- Normal Physiology.- Pathophysiology: The Anovulatory Woman.- Therapeutic Developments.

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Book SynopsisVector Analysis.- Sources and Fields.- Bioelectric Potentials.- Channels.- Action Potentials.- Impulse Propagation.- Electrical Stimulation.- Extracellular Fields.- Cardiac Electrophysiology.- The Neuromuscular Junction.- Skeletal Muscle.- Functional Electrical Stimulation.- Exercises.Trade ReviewPraise for Previous Editions:"This fine text, by two well-known bioengineering professors at Duke University, is an introduction to electrophysiology aimed at engineering students. Most of its chapters cover basic topics in electrophysiology: the electrical properties of the cell membrane, action potentials, cable theory, the neuromuscular junction, extracellular fields, and cardiac electrophysiology. The authors discuss many topics that are central to biophysics and bioengineering [and] the quantitative methods [they] teach will surely be productive in the future." IEEE Engineering in Medicine and Biology "The authors’ goal in producing this book was to provide an introductory text to electrophysiology, based on a quantitative approach. In attempting to achieve this goal, therefore, the authors have opened the book with a useful, and digestible, introduction to various aspects of the mathematics relevant to this field, including vectors, introduction to Laplace, Gauss’s theorem, and Green’s theorem. This book will be useful for students in medical physics and biomedical engineering wishing to enter the field of electrophysiological investigation. It will also be helpful for biologists and physiologists who wish to understand the mathematical treatment of the processes and signals at the center of the interesting interdisciplinary field." Medical and Biomedical Engineering and ComputingTable of ContentsVector Analysis.- Sources and Fields.- Bioelectric Potentials.- Channels.- Action Potentials.- Impulse Propagation.- Electrical Stimulation.- Extracellular Fields.- Cardiac Electrophysiology.- The Neuromuscular Junction.- Skeletal Muscle.- Functional Electrical Stimulation.- Exercises.

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Book SynopsisDefined as, “The science about the development of an embryo from the fertilization of the ovum to the fetus stage,” embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a “development cell.” That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies.Trade ReviewFrom the reviews:“The Introduction by the two editors is clearly telling the aim of such a bible, to cover from the basic aspects of molecular embriology dealing with the stemness cellular capacity … till the new challenging opportunities of tissue engineering. I think the price of the book (€ 170) is worthy enough for what the reader will get. … a book with all the figures in colour, this is a great help while looking at cytology, histology or entangled graphs!” (Carlo Alberto Redi, European Journal of Histochemistry, Vol. 55, 2011)Table of ContentsSection 1: Stem Cell Biology.- Introduction to Stem Cells & Regenerative Medicine.- Embryonic Stem Cells: Discovery, Development, and Current Trends.- Bmi1 in self-renewal and homeostasis of pancreas.- Cancer Stem Cells in Solid Tumors.- Adipose-derived stem cells and skeletal muscle repair.- Regeneration of sensory cells of adult mammalian inner ear.- Stem Cells and Their Use in Skeletal Tissue Repair.- Section 2: Epigenetic and microRNA Regulation in Stem Cells.- Epigenetic identity in cancer stem cells.- Function of MicroRNA-145 in Human Embryonic Stem Cell Pluripotency.- Mesenchymal Stem Cells for Liver Regeneration.- Section 3: Stem Cells for Therapeutic Applications.- The Role of Time-Lapse Microscopy in Stem Cell Research and Therapy.- Therapeutic applications of mesenchymal stem/multipotent stromal cells.- Gastrointestinal stem cells.- Lung epithelial stem cells.- Placental Derived Stem Cells, Potential Clinical Applications.- Bone Marrow Cell Therapy for Acute Myocardial Infarction: A Clinical Trial Review.- Stem cell Transplantation to the Heart.- Adult Neural Progenitor Cells and Cell Replacement Therapy for Huntington’s Disease.- Migration of Transplanted Neural Stem Cells in Experimental Models of Neurodegenerative Diseases.- Prospects for neural stem cell therapy of Alzheimer’s disease.- Section 4: Nuclear Reprogramming and induced Pluripotent Stem Cells.- Nuclear transfer ES cells as a new tool for basic biology.- Pluripotent stem cells in reproductive medicine: Formation of the human germ line in vitro.- Prospects for Induced Pluripotent Stem Cell Therapy for Diabetes.- Keratinocyte induced pluripotent stem cells: from hair to where?.- Generation and Characterization of Induced Pluripotent Stem Cells from Pig.- Induced pluripotent stem cells, on the road toward clinical applications.- Direct reprogramming of human neural stem cells by the single transcription factor Oct 4.- Section 5: Tissue Engineering.- Stem cells and biomaterials: the tissue engineering approach.- Micro-technology for stem cell culture.- Using Lab-on-A-Chip Technologies for Stem cell Biology.- The Development of Small Molecules and Growth Supplements to Control the Differentiation of Stem Cells and the Formation of Neural Tissues.- Long-term propagation of neural stem cells: Focus on 3D culture systems and mitogenic factors.- Section 6: Regenerative Medicine.- Stem Cells and Regenerative Medicine in Urology.- Muscle derived stem cells: a model for stem cell therapy in regenerative medicine.- Regenerative strategies for cardiac disease.- Collecting, Processing, Banking and Use of Cord Blood Stem Cells for Regenerative Medicine.

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Book SynopsisTo thrive, every living cell must continuously gauge and respond to changes in its environment. These changes are ultimately implemented by modulating gene expression, a process that relies on transcription by Nature’s most multivalent molecular machine, the RNA polymerase. This book covers progress made over the past decade understanding how this machine functions to compute the cellular state, from the atomistic structural level responsible for chemistry to the integrative level at which RNA polymerase interacts with the other key molecular machineries of the cell.Table of ContentsThe Transition from Transcription Initiation to Transcription Elongation: Start Site Selection, Initial Transcription, and Promoter Escape; Molecular Basis for Transcriptional Fidelity Control by RNA Polymerase II; 1RNA Polymerase as a Torsional Motor; RNA Polymerase-associated Transcription Elongation Factors; Rho Termination Factor: One Ring to Bind Them All; Global Regulation of Transcription by Nucleotides and (p)ppGpp; Helicases and the Obstructive RNAP; Transcription/Replication Conflicts, Resolution and Coregulation; Using Single-cell RNA Measurements to Decipher the Stochastic Kinetics of Transcription; Molecular Dynamics Simulations and Kinetic Network Models Elucidate RNA Polymerase Transcription Elongation Mechanisms

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Book SynopsisElectrogenerated chemiluminescence (ECL) is a powerful and versatile analytical technique, which is widely applied for biosensing and successfully commercialized in the healthcare diagnostic market. After introducing the fundamental concepts, this book will highlight the recent analytical applications with a special focus on immunoassays, genotoxicity, imaging, DNA and enzymatic assays. The topic is clearly at the frontier between several scientific domains involving analytical chemistry, electrochemistry, photochemistry, materials science, nanoscience and biology. This book is ideal for graduate students, academics and researchers in industry looking for a comprehensive guide to the different aspects of electrogenerated chemiluminescence.Trade ReviewThe book is well developed, and the topic is presented with a clear logic. The present book is a needed contribution, it allows to easily access the topic and provides comprehensive insights of both the theoretical aspects and recent technological advancement. It provides a unique resource of information and a reference point to researchers in the physical, chemical, and biological sciences. -- Federico Polo, Ca’ Foscari University of Venice * https://doi.org/10.1007/s00216-020-02744-z *Table of ContentsIntroduction and Overview of Electrogenerated Chemiluminescence; Energetic and Kinetic Aspects of ECL Generation; Efficient ECL Luminophores; Electrochemiluminescence Coreactants; Theoretical Concepts Underlying ECL Generation; The Essential Role of Electrode Materials in ECL Applications; Wireless ECL Generation Based on Bipolar Electrochemistry; Multicolour Electrochemiluminescence; ECL of Nanomaterials: Novel Materials, Detection Strategies and Applications; ECL Detection of Nanoparticles; Single Entity Electrogenerated Chemiluminescence; Enzymatic Assays; DNA-based ECL Assays; Microfluidic ECL and Voltammetric Arrays for Metabolite-related DNA Damage; Automated Immunoassays for the Detection of Biomarkers in Body Fluids; Electrochemiluminescence Imaging

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Book SynopsisProtein-protein interactions (PPI) are at the heart of the majority of cellular processes, and are frequently dysregulated or usurped in disease. Given this central role, the inhibition of PPIs has been of significant interest as a means of treating a wide variety of diseases. However, there are inherent challenges in developing molecules capable of disrupting the relatively featureless and large interfacial areas involved. Despite this, there have been a number of successes in this field in recent years using both traditional drug discovery approaches and innovative, interdisciplinary strategies using novel chemical scaffolds. This book comprehensively covers the various aspects of PPI inhibition, encompassing small molecules, peptidomimetics, cyclic peptides, stapled peptides and macrocycles. Illustrated throughout with successful case studies, this book provides a holistic, cutting-edge view of the subject area and is ideal for chemical biologists and medicinal chemists interested in developing PPI inhibitors.Table of ContentsIdentification of Cellular Protein-protein Interactions; Target-based Screening and Structure-based Design Approaches to Develop Modulators of Protein-protein Interactions; The Challenge of Prosecuting Intracellular Protein-Protein Interactions: A Multi-Modality Examination of Chemical Matter Identification, Biophysical Characterization, and Membrane Permeability; Identifying and Developing Small Molecule Inhibitors of Protein-protein Interactions; Macrocycles as Inhibitors of Protein-Protein Interactions; Genetically-encoded SICLOPPS Libraries for the Identification of PPI Inhibitors; RaPID Discovery of Macrocyclic Peptide Inhibitors of Protein-protein Interactions; Bicyclic Peptide Inhibitors of Protein-Protein Interactions; Stapled Peptide Inhibitors of Protein-Protein Interactions; -Helix Mimetics as Inhibitors of Protein-Protein Interactions

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Book SynopsisBiophysical Chemistry covers the physical chemistry of biological macromolecules and the experimental techniques used to study them. Topics covered include: an introduction to biological molecules; spectroscopy, mass spectrometry and hydrodynamics of macromolecules; a ""bluffer's guide"" to molecular thermodynamics; biomolecular kinetics; chromatography and electrophoresis; and single-molecule methods. The easily digestible, pragmatic approach captures the reader with the fascinating challenges the subject poses for theoretical and experimental scientists. This book will be ideal for early undergraduates studying chemical or physical sciences and will act as a basis for more advanced study. Students in other areas of biological sciences will appreciate the less intimidating approach to physical chemistry as demonstrated here. Ideal for the needs of undergraduate chemistry students, Tutorial Chemistry Texts is a major series consisting of short, single topic or modular texts concentrating on the fundamental areas of chemistry taught in undergraduate science courses. Each book provides a concise account of the basic principles underlying a given subject, embodying an independent-learning philosophy and including worked examples.Trade ReviewIdeal for early undergraduates studying chemical or physical sciences and will act as a basis for more advanced study. Students in other areas of biological sciences will appreciate the less intimidating approach to physical chemistry as demonstrated here."Will be of great help to early undergraduates in first years of physical, chemical, and biological studies and specialised scientists in specific fields of the life sciences."Table of ContentsBiological Molecules; Spectroscopy; Mass Spectrometry; Hydrodynamics; Thermodynamics and Interactions; Kinetics; Chromatography and Electrophoresis; Single Molecules; Subject Index.

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Book SynopsisThis book provides readers with the necessary background information and advanced concepts in the field of circuits, at the crossroads between physics, mathematics and system theory. It covers various engineering subfields, such as electrical devices and circuits, and their electronic counterparts. Based on the idea that a modern university course should provide students with conceptual tools to understand the behavior of both linear and nonlinear circuits, to approach current problems posed by new, cutting-edge devices and to address future developments and challenges, the book places equal emphasis on linear and nonlinear, two‐terminal and multi‐terminal, as well as active and passive circuit components. This second volume focuses on dynamical circuits, which are characterized by time evolution and by the concept of state. The content is divided into a set of introductory and a set of advanced‐level topics, mirroring the approach used in the previously published volume. Whenever possible, circuits are compared to physical systems of different natures (e.g. mechanical or biological) that exhibit the same dynamical behavior. The book also features a wealth of examples and numerous solved problems. Further topics, such as a more general framing of linear and nonlinear components, will be discussed in volume 3. Trade Review“This is volume 2 of a basic book on linear and nonlinear circuits for undergraduate electrical engineering students.” (Wai-Kai Chen, zbMATH 1492.94002, 2022)Table of ContentsBasic concepts: two-terminal linear elements with memory and first-order linear circuits.- Advanced concepts: first-order nonlinear circuits.- Basic concepts: linear two-ports with memory and higher-order linear circuits.- Advanced concepts: Higher-order nonlinear circuits – State equations and equilibrium points.- Basic concepts: Analysis of LTI circuits in sinusoidal steady state.- Advanced concepts: Analysis of nonlinear oscillators.

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Book SynopsisThis comprehensive and extensively classroom-tested biophysics textbook is a complete introduction to the physical principles underlying biological processes and their applications to the life sciences and medicine. The foundations of natural processes are placed on a firm footing before showing how their consequences can be explored in a wide range of biosystems. The goal is to develop the readers’ intuition, understanding, and facility for creative analysis that are frequently required to grapple with problems involving complex living organisms. Topics cover all scales, encompassing the application of statics, fluid dynamics, acoustics, electromagnetism, light, radiation physics, thermodynamics, statistical physics, quantum biophysics, and theories of information, ordering, and evolutionary optimization to biological processes and bio-relevant technological implementations. Sound modeling principles are emphasized throughout, placing all the concepts within a rigorous framework. With numerous worked examples and exercises to test and enhance the reader’s understanding, this book can be used as a textbook for physics graduate students and as a supplementary text for a range of premedical, biomedical, and biophysics courses at the undergraduate and graduate levels. It will also be a useful reference for biologists, physicists, medical researchers, and medical device engineers who want to work from first principles.Table of ContentsChapter1: Introduction: The Nature of Biophysics.- Chapter2: The Kinds of Ordinary Materials.- Chapter3: Mechanical Aspects of Biosystems.- Chapter4: Fluid Mechanics Applied to Biosystems.- Chapter5: Acoustics in Biology and Medicine.- Chapter6: Electric and Magnetic Fields in Life.- Chapter7: Light in Biology and Medicine.- Chapter8: Ionizing Radiation and Life.- Chapter9: Bioenergetics.- Chapter10: The Statistical Basis of Bioenergetics.- Chapter11: Biomolecular Structure and Interactions.- Chapter12: Entropy and Information in Biology.- Chapter13: Modeling Biological Systems.- Chapter14: Neural Networks and Brains.- Chapter15: Ordering Theory.- Chapter16: Energy Flow in the Production of Order.- Chapter17: Life in the Universe.- Chapter18: Future Developments.

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Book SynopsisThis book illustrates how modern mathematical wavelet transform techniques offer fresh insights into the complex behavior of neural systems at different levels: from the microscopic dynamics of individual cells to the macroscopic behavior of large neural networks. It also demonstrates how and where wavelet-based mathematical tools can provide an advantage over classical approaches used in neuroscience. The authors well describe single neuron and populational neural recordings.This 2nd edition discusses novel areas and significant advances resulting from experimental techniques and computational approaches developed since 2015, and includes three new topics:• Detection of fEPSPs in multielectrode LFPs recordings.• Analysis of Visual Sensory Processing in the Brain and BCI for Human Attention Control;• Analysis and Real-time Classification of Motor-related EEG Patterns;The book is a valuable resource for neurophysiologists and physicists familiar with nonlinear dynamical systems and data processing, as well as for graduate students specializing in these and related areas.Table of ContentsMathematical Methods of Signal Processing in Neuroscience.- Brief Tour of Wavelet Theory.- Analysis of Single Neuron Recordings.- Classification of Neuronal Spikes from Extracellular Recordings.- Analysis of Gamma-Waves in Multielectrode LFP Recordings.- Wavelet Approach to the Study of Rhythmic Neuronal Activity.- Wavelet-based Approach to Epilepsy.- Analysis of Visual Sensory Processing in the Brain and Brain-Computer Interfaces for Human Attention Control.- Analysis and Real-Time Classification of Motor-related EEG and MEG Patterns.- Conclusion.

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Book SynopsisThis textbook describes the basic principles and mechanism of action of biosensor systems, and introduces readers to the various types of biosensors; from affinity biosensors to catalytic, optical and label-free biosensors, the most common systems are explained in detail. Dedicated advanced sections focus on biochips and genome sequencing methods as well as organs-on-a-chip. The textbook helps readers to understand the elementary components of biosensors, and to identify and illustrate each function in the biosensor information flow, from recognition to transduction and transmission. Furthermore, readers will receive guidance in critically analyzing published studies on biosensor research, helping them to develop appropriate concepts and independently propose their own solutions. The textbook is intended for master’s students in bioengineering, biophysics, biotechnology and pharmacology that need a solid grasp of biosensor system technologies and applications, as well as students in related medical technological fields.Table of Contents

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Book SynopsisThis book presents a step by step design approach to develop and implement an IoT system starting from sensor, interfacing to embedded processor, wireless communication, uploading measured data to cloud including data visualization along with machine learnings and artificial intelligence. The book will be extremely useful towards a hands-on approach of designing and fabricating an IoT system especially for upper undergraduate, master and PhD students, researchers, engineers and practitioners.Table of ContentsIoT System Design– The Big Picture.- Design Considerations for IoT node.- Programming Arduino for IoT System.- Bluetooth based IoT System.- Cloud Computing for IoT Systems.- Simulation based Projects on IoT Systems.

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Book SynopsisThis book provides an interesting snapshot of recent advances in the field of single molecule nanosensing. The ability to sense single molecules, and to precisely monitor and control their motion is crucial to build a microscopic understanding of key processes in nature, from protein folding to chemical reactions. Recently a range of new techniques have been developed that allow single molecule sensing and control without the use of fluorescent labels. This volume provides an overview of recent advances that take advantage of micro- and nanoscale sensing technologies and provide the prospect for rapid future progress. The book endeavors to provide basic introductions to key techniques, recent research highlights, and an outlook on big challenges in the field and where it will go in future. It is a valuable contribution to the field of single molecule nanosensing and it will be of great interest to graduates and researchers working in this topic.Table of ContentsPart I Optical Sensing.- Interferometric Biosensing.- Optoplasmonic Whispering Gallery Mode Sensors for Single Molecule Characterization: A Practical Guide.- Nonlinear Optical Microcavities Towards Single-Molecule Sensing.- Part II Optomechanical Sensing.- Optomechanical Sensing.- Quantum Optical Theories of Molecular Optomechanics.- Part III Biomolecular Manipulation.- Dielectrophoresis of Single Molecules.- Optical Trapping of Single Molecules.- Applications of Trapping to Protein Analysis and Interactions.- Towards Single-Molecule Chiral Sensing and Separation.- Part IV Nanopores.- Experimental Approaches to Solid-State Nanopores.- Challenges in Protein Sequencing using 2-D MoS2 Nanopores.- Single-molecule Ionic and Optical Sensing with Nanoapertures.- Self-induced Back-action Actuated Nanopore Electrophoresis (SANE) sensing.

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Book SynopsisPart I: The Viral Machine.- Chapter 1: Introduction, The Structural Basis of Virus Function.- Chapter 2: The Basic Architecture of Viruses.- Part II: Determination of the Structure, Dynamics and Physical Properties of Viruses.- Chapter 3: Conventional Electron Microscopy, Cryogenic Electron Microscopy and Cryogenic Electron Tomography of Viruses.- Chapter 4: X-Ray Crystallography of Viruses.- Chapter 5: Nuclear Magnetic Resonance Spectroscopy to study Virus Structure.- Chapter 6: Fluorescence, Circular Dichroism and Mass Spectrometry as Tools to Study Virus Structure.- Chapter 7: Integrative Approaches to Study Virus Structures.- Chapter 8: 3D Cryo-Correlative Methods to Study Virus Structure and Dynamics within Cells.- Chapter 9: Atomic Force Microscopy of Viruses.- Chapter 10: Optical Tweezers to Study Viruses.- Part III: Structural Foundations of Virus Properties and Functions.- Chapter 11: Assembly of Structurally Simple Icosahedral Viruses.- Chapter 12: Architecture and Assembly of Structurally Complex Viruses.- Chapter 13: Nucleic Acid Packaging in Viruses.- Chapter 14: Maturation of Viruses.- Chapter 15: Virus-Receptor Interactions and Receptor-Mediated Virus Entry into Host Cells.- Chapter 16: Entry of Enveloped Viruses into Host Cells: Membrane Fusion.- Chapter 17: Bacteriophage Receptor Recognition and Nucleic Acid Transfer.- Chapter 18: Mechanical Properties of Viruses.- Chapter 19: Theoretical Studies on Assembly, Physical Stability and Dynamics of Viruses.- Part IV: Applied Structural and Physical Virology.- Chapter 20: Antiviral Agents: Structural Basis of Action and Rational Design.- Chapter 21: Design of Novel Vaccines Based on Virus-Like Particles.- Chapter 22: Engineering and Bio/Nanotechnological Applications of Virus Particles.

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Book Synopsis1. Intermittent motion of agents.- 2. Visual search.- 3. Subdiffusive search for a target.- 4. Superdiffusive search for a target.- 5. Evanescent searchers.

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Table of ContentsFrontmatter -- List of authors -- Preface -- Contents -- I. General Problems of Biological Thermodynamics -- Introduction -- Application of the Concepts of Classical Thermodynamics in Biology -- The Second Law, Negentropy, Thermodynamics of Linear Irreversible Processes -- Formalism of Non-Equilibrium Phenomenolagical Thermodynamics -- II. Qualitative Phenomenological Theory of the Development of Organisms -- Introduction -- Experimental Basis for Qualitative Phenomenological Theory of Development -- Theoretical Basis for a Qualitative Phenomenological Theory of Development -- Stochastic Consideration of Constitutive Processes and of the Evolution Criterion -- Strengthened Evolution Criterion in Developmental Biology -- III. Quantitative Phenomenological Theory of Development of Organisms -- Introduction -- Non-Linear Phenomenological Equations -- Differential Equations of Developmental Biology -- Computer Analysis of Non-Linear Growth Equations -- Modern Theories Concerning the Growth Equations -- IV. Heat Production of Living Systems -- Introduction -- Heat Production in Life Processes -- The Change of ?? the Function During the Growth of Microbial Cultures -- Changes of ?? and ?? Functions During Oogenesis of Xenopus Laevis -- Heat Production and Respiration During Development and Growth of two Insects -- Heat Production and Respiration of Axolotle at the Early Stages of Growth -- Relationship Between Heat Production and Body Weight in Growing Organisms -- V. Some Problems of Energetics of Developmental Processes -- Introduction -- Changes in Mitochondria During Development and Growth of Animals -- The Role of Mitochondria in Regulation of Respiration During Oogenesis -- The Energetics of Regeneration Processes -- VI. Dissipative Structures -- Introduction -- Review of the Theory of Dissipative Structures -- Stationary Dissipative Structures -- Dynamic Dissipative Structures -- Dissipative Structures and ?? Function -- The Role of Cyclization of Free Energy in Bio-Physico-Chemical Processes -- VII. Probability State and Orderliness of Biological Systems -- Introduction -- Possible Mechanism of the Origin of Bacteria -- Direction of the Evolutionary Progress of Organisms -- Criterion of Orderliness and some Problems of Taxonomy -- The Questions of Non-Linearity for Using Criterion of Orderliness -- Concluding Remarks -- References -- Index -- Backmatter

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Book SynopsisThis two volume set introduces the up-to-date high-tech applications of Aggregation-Induced Emission (AIE) luminogens mainly in the areas of biosensing, bioimaging, and biomedicine. The 1st volume covers the applications of AIE materials in biosensing and bioimaging, including the technological utilizations in ionic/biomolecular sensing, bacterial imaging, cell imaging, intracellular microenvironment analysis, advanced optical imaging and multimodality, etc. It is an essential reference for materials scientists, chemists, physicists and biological chemists.

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Book SynopsisThis two volume set introduces the up-to-date high-tech applications of Aggregation-Induced Emission (AIE) luminogens in biosensing, bioimaging, and biomedicine. The 2nd volume presents the applications of AIE materials in biomedicine, including the utilizations in biomedical polymers, organic nanoprobes, photosensitizer, photothermal agents, AIEgens-based delivery systems, etc. It is an essential reference for materials scientists, chemists, physicists and biological chemists.

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Book SynopsisIn this book, physics in its many aspects (thermodynamics, mechanics, electricity, fluid dynamics) is the guiding light on a fascinating journey through biological systems, providing ideas, examples and stimulating reflections for undergraduate physics, chemistry and life-science students, as well as for anyone interested in the frontiers between physics and biology.Rather than introducing a lot of new information, it encourages young students to use their recently acquired knowledge to start seeing the physics behind the biology. As an undergraduate textbook in introductory biophysics, it includes the necessary background and tools, including exercises and appendices, to form a progressive course. In this case, the chapters can be used in the order proposed, possibly split between two semesters. The book is also an absorbing read for researchers in the life sciences who wish to refresh or go deeper into the physics concepts gleaned in their early years of scientific training. Less physics-oriented readers might want to skip the first chapter, as well as all the "gray boxes" containing the more formal developments, and create their own á-la-carte menu of chapters.Trade Review“Cleri does a masterful job of integrating the history of science with some of the most recent results, in order to give the reader a comprehensive view of where our field has been, and where it now stands. … figures help to bring the material alive, and the detailed ‘grey boxes’ provide important context. … includes a number of challenging and subtle questions at the end of each chapter, guaranteed to make the student (and instructor) think deeply.” (Sonya Bahar, Journal of Biological Physics, 2016)Table of ContentsThermodynamics for Living Systems, Appendix, Problems, References.- Energy, Information and the Origins of Life, Problems, References.- Energy Production and Storage for Life, Problems, References.- Entropic Forces in Cells: Thermodynamics and Hydrodynamics, Problems, References.- Molecular Motors in the Cell, Appendix, Problems, References.- Bioelectricity, Hearts and Brains, Problems, References.- Elasticity and Mechanics of Cells and Tissues, Appendix, Problems, References.- Muscles as Engines, Problems, References.- Physical Variables in Living Systems, Problems, References.- Shapes of Nature, Problems, References.- The Hidden Mathematics of Living Systems, Problems, References.

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Book SynopsisWhat are the relations between the shape of a system of cities and that of fish school? Which events should happen in a cell in order that it participates to one of the finger of our hands? How to interpret the shape of a sand dune? This collective book written for the non-specialist addresses these questions and more generally, the fundamental issue of the emergence of forms and patterns in physical and living systems. It is a single book gathering the different aspects of morphogenesis and approaches developed in different disciplines on shape and pattern formation. Relying on the seminal works of D’Arcy Thompson, Alan Turing and René Thom, it confronts major examples like plant growth and shape, intra-cellular organization, evolution of living forms or motifs generated by crystals. A book essential to understand universal principles at work in the shapes and patterns surrounding us but also to avoid spurious analogies.Table of ContentsIntroduction.- Self-organization at equilibrum. A model system: ferrofluids.- Hierarchical networks of fractures.- Liquid crystals and morphogenesis.- Biological self-organization by way of the dynamics of reactive processes.- Sand dunes.- Morphodynamics of secretory pathways.- From epigenomics to morphogenetic emergence.- Animal morphogenesis.- Phyllotaxy.- Logic of forms.- Forms emerging from collective motion.- Systems of cities and levels of organization.- Levels of organization and morphogenesis: the viewpoint of D'Arcy Thompson.- Morphogenetic models of René Thom.- Morphogenesis, structural stability and epigenetic landscape.- Morphological and mutational analysis: tools for morphogenesis study.- Morphogenesis in computer science.

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Book SynopsisIntroduction.- What you should have heard somewhere.- Passive motion by diffusion.- On the mechanics of beams, polymers and membranes.- Active motion and enzyme kinetics.- What we didn't talk about.- Bibliography.- Index.

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Book SynopsisThis volume presents a considerable number of interrelated contributions dealing with the new scientific ability to shape and control matter and electromagnetic fields on a sub-wavelength scale.The topics range from the fundamental ones, such as photonic metamateriials, plasmonics and sub-wavelength resolution to the more applicative, such as detection of single molecules, tomography on a micro-chip, fluorescence spectroscopy of biological systems, coherent control of biomolecules, biosensing of single proteins, terahertz spectroscopy of nanoparticles, rare earth ion-doped nanoparticles, random lasing, and nanocoax array architecture.The various subjects bridge over the disciplines of physics, biology and chemistry, making this volume of interest to people working in these fields. The emphasis is on the principles behind each technique and on examining the full potential of each technique.The contributions that appear in this volume were presented at a NATO Advanced Study Institute that was held in Erice, Italy, 3-18 July, 2011. The pedagogical aspect of the Institute is reflected in the topics presented in this volume.Table of ContentsPreface.- List of Past Institutes.- Lectures.- Real-time Optical Detection of Single Nanoparticles and Viruses using Heterodyne Interferometry; A. Mitra, L. Novotny.- Photonics Metamaterials and Transformation Optics; M. Wegener.- Plasmonic Enhancement of Light Emission and Scattering in Nanostructures; S. V. Gaponenko.- Sub-Wavelength Optical Fluorescence Microscopy for Biological Applications; P. N. Hedde, G. U. Nienhaus.- Raman Spectroscopy and Optical Coherence Tomography on a Micro-Chip; M. Pollnau et al.- Introduction to Fluorescence Spectroscopy with Applications in Biological Systems; B. Di Bartolo.- NanoPhotonics; C. Evans, E. Mazur.- Synthesis and Spectroscopy of Nanoparticles; A. P. Voitovich et al.- Photonic-Crystal Fiber Platform for Ultrafast Optical Science; A. Zheltikov.-Structure Property Relationships for Exciton Transfer in Conjugated Polymers; T. L. Andrews, T. M. Swager.- Coherent Control of Biomolecules and Imaging using Nanodoublers; L. Bonacina , J. P. Wolf.- Taking Whispering Gallery Mode Biosensing to the Single Protein Limit; S. Arnold et al.- Terahertz Spectroscopy and Imaging at the Nanoscale for Biological and Security Applications; J. W. Bowen.- Applications of Plasmonics in Biophotonics ; A. Heisterkamp et al.- Principles and Applications of Rare Earth Ion-Doped Nanoparticles ; J. M. Collins.- Is There Segregation in of Rare Earth Ions in Garnet Optical Ceramics; G. Boulon et al.- Random Lasing in Solid State Materials ; J. Fernandez et al.- Imprint-Templated Nanocoax Array Structure; M. J. Naughton.- Short Seminars.- Metallic Nanoclusters in Layered Crystals: Spectroscopy and Computer Simulations; I. Karbovnyk et al.- Optical Antennas for Single Emitter Fluorescence Enhancement; P. Bharadwaj, L. Novotny.- Ultrafast All-Optical Switching in TiO2; C. Evans et al.- Coherent Manipulation of Motional States of a Single Trapped Ion; A. S. Villar.-Thermalization of an Open Quantum System via Full Diagonalization; K. Jacobs, L. Silvestri.- The Role of Localized and Propagating Surface Plasmons in Periodically-Arrayed Nanopillars; F. J. Bezares et al.- Optical and Structural Properties of Noble Metal Island Films; M. Lončarić et al.- Localized Photonics States in Two-Dimensional Quasi-Crystalline Waveguides; G. Benedeck, A. Trabattoni.- Unified Theoretical Model of Loss Compensation and Energy Transfer for Plasmonic Nanoparticles Coated with a Shell of Active Gain Molecules; V. Pustovit et al.- Poster Presentations.- Deep UV Strategy for Discriminating Biomolecules; S. Afonina et al.- Silicon Nanowires Light Emitting Devices at Room Temperature; P. Artoni et al.- Optical and Structural Properties of Europium Oxide Thin Films on Si Substrates; G. Bellocchi et al.- Experimental Indication of Quantum Mechanical Effects in Surface Enhaced IR-Spectroscopy? ; J. Bochterle et al.- Spectral Dependence of the Amplification Factor in Surface Enhanced Raman Scattering ; C. D’Andrea et al.- Investigation of the Metal-Superconductor Hybrid Nanostructure as an Active Medium for Laser; A. Eid et al.- TiO2 for Nonlinear Optical Devices; C. Evans et al.- Atomic Layer Deposition of Lanthanide Oxides; P. A. Hansen et al.- Tip-Enhanced Raman Scattering from Bridged Metal Nanocones; M. J. Huttunen et al.- Femtosecond Laser Nanofabrication of Metal Structures through Multiphoton Photoreduction; S. Y. Kang et al.- Nanostructured Thick-Film Spinel Ceramic Materials for Sensor Device Applications; H. Klym, I. Karbovnyk.- Realization of a Two-Dimensional Isotropic Metamaterials; J. Kaschke et al.- Nanoscale Seminconductor Optical Devices; N. Kuznetsova et al.- Optical Properties of Thermochromic VO2 Nanoparticles; K. Laaksonen et al.- Lithium Niobate: The Silicon of Photonics!; M. Manzo et al.- Infrared Induced White Anti-Stokes Emissions LiYbP4O12 Nanocrystals; L. Marciniak et al.- Enhanced Light Emission from Si Nanocrystals Coupled to Plasmonic Structures; E. Massa et al.- A Spintronic Single Photon Source and Spin Manipulation in Spininjection-LEDs; A. Merz.- Polarizing Beam Splitters; J. Mueller, M. Wegener.- Point Defects Aggregation in LiF Crystals After Irradiation; A. P. Voitovich et al.- Diamond Photonic Crystal Slab with Enhanced Photoluminescence Extraction Efficiency; L. Ondič, I. Pelant.- Spectral Markers of Erythrocytes on Solid Substrate; A. A. Paiziev, V.A. Krakhmalev.- Lanthanide Doped Nanocrystalline Alkaline Earth Fluorides: Synthesis, Structural, Morphological and Spectroscopic Investigation; M. Pedroni et al.- Observation of Surface Plasmon in Metal-Coated Tapered Fiber Terminated by a Subwalength Aperture; V. Palm et al.- Fabrication of Single Photon Sources by Use of Pyramidal Quantum Dot Microcavities; D. Rülke et al.- Investigation of GaN- and CuInGaSe2- Based Heterostructures for Optoelectronics Applications; M. Z. Rzheutski et al.- Ebic Investigation of the Recombination at the Edges of GaAs Solar Cells; A. Scacabarozzi, M. Acciarri.- Dynamical Properties of Cardiomyocytes in Three-Dimensional Polymer Scaffolds; A. Scheiwe et al.- Femtosecond Laser Doped Silicon Photovoltaic Applications; M. J. Sher et al.- Laser and Optical Properties of Green-Emitting ZnCdSe Quantum Dot Based Heterostructures; A. G. Vainilovich et al.- Stokes Parameters Measurements for Whispering Gallery Modes Microcavities Characterization; F. Vanier et al.- Photonic Crystal Fiber Synthesizer for Ultrafast Lightwaves; A. A. Voronin et al.- Single Nanoparticle Surface Enhanced Fluorescence; L. R. Webster et al.- List of Participants.- Index.-

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Book SynopsisThis highly unusual book began as a serious inquiry into Schrödinger's question, “What is life?”, and as a celebration of life itself. It takes the reader on a voyage of discovery through many areas of contemporary physics, from non-equilibrium thermodynamics and quantum optics to liquid crystals and fractals, all necessary for illuminating the problem of life. In the process, the reader is treated to a rare and exquisite view of the organism, gaining novel insights not only into the physics, but also into “the poetry and meaning of being alive.”This much-enlarged third edition includes new findings on the central role of biological water in organizing living processes; it also completes the author's novel theory of the organism and its applications in ecology, physiology and brain science.Table of ContentsWhat Is It to Be Alive?; Do Organisms Contravene the Second Law?; Can the Second Law Cope with Organized Complexity?; Energy Flow and Living Cycles; How to Catch a Falling Electron; Towards a Thermodynamics of Organised Complexity; Sustainable Systems as Organisms; The Seventy-Three Octaves of Nature's Music; Coherent Excitations of the Body Electric; The Solid-State Cell; 'Life is a Little Electric Current'; How Coherent Is the Organism? The Heartbeat of Health; How Coherent Is the Organism? Sensitivity to Weak Electromagnetic Fields; Life is All the Colors of the Rainbow in a Worm; The Liquid Crystalline Organism; Crystal Consciousness; Liquid Crystalline Water; Quantum Entanglement and Coherence; Ignorance of the External Observer; Time and Freewill.

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Book Synopsis1. Electromagnetic Modeling and Optimization of Terahertz Wideband Filters Using an Inverse Convolutional Neural Network with Transfer Function.- 2. All-Dielectric Metasurface Design for High-Performance Vortex Beam Generation in the Terahertz Regime.- 3. Spin-Momentum Locked Field Distribution in Smith-Purcell Radiation.- 4. Generation of Tunable Terajets Using Optical Elements Designed with Quadratic Bézier Curves.- 5. Optimization Design of a Full-Space Terahertz Vortex Beam Generator Based on Deep Learning.

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Book Synopsis

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Book SynopsisThis monograph presents a general mathematical theory for biological growth. The author herein presents the first major technical monograph on the problem of growth since D’Arcy Wentworth Thompson’s 1917 book On Growth and Form.The emphasis of the book is on the proper mathematical formulation of growth kinematics and mechanics.Trade Review“Goriely’s book is self-contained and provides sufficient review of the background material necessary to understand the mathematics employed in the study of phenomena he describes. … Overall, the text is well written, richly illustrated, and enjoyable to read, although the monograph is lengthy. I applaud Prof. Goriely on his impressive text.” (Bhargav Karamched, SIAM Review, Vol. 61 (1), March, 2019)“The book grasps the conceptual and technical aspects underpinning the role of mechanics in the growth of biological tissues. It is the first major modern monograph on the subject, which synthesizes the research activity in this vivid field of the mathematics and mechanics of growth since now more than two decades. … The monograph is overall well-structured and rich in illustrations and will be accessible and appealing to readers with different interest and background, including life scientists … .” (Jean-François Ganghoffer, Journal of Geometry and Symmetry in Physics JGSP, Vol. 49, 2018)“The book is very informative, it is written in an easy readable and intriguing way. It has a large reference list of 1369 bibliographic descriptions and a carefully prepared index. The book should be helpful for researchers who work in the multidisciplinary fields of theoretical biology, biomechanics, biomedical engineering, biophysics and applied mathematics.” (Svetoslav Markov, zbMATH 1398.92003, 2018)Table of ContentsBasic aspects of growth.- Mechanics and growth.- Discrete computational models.- Growing on a line.- Elastic rods.- Morphoelastic rods.- Accretive growth.- Membranes and shells.- Growing membranes.- Morphoelastic plates.- Nonlinear elasticity.- The kinematics of growth.- Balance laws.- Evolution laws and stability.- Growing spheres.- Growing cylinders.- Ten challenges.- References.- Index.

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Book SynopsisOffering an authoritative and timely account by twenty-nine internationally recognized experts, Metal Ions in Biological Systems: Metal Complexes in Tumor Diagnosis and as Anticancer Agents is devoted solely to the vital research area concerning metal complexes in cancer diagnosis and therapy. In fourteen stimulating chapters, the book focuses on diagnostic tools such as magnetic resonance imaging (MRI), luminescent probes, and radiopharmaceuticals, including radiometallo-labeled peptides and assesses the role of metal ions, especially iron, in the action of antibiotics employed in anticancer chemotherapy.Trade Review"This is one of two recent volumes in a most successful series publishes since 1973 and which enjoys world renown and respect as both reference and as training material; the current volume is no exception. … [T]his is a gem of a book for both newcomers and established researchers in the field; long may they continue!" - Applied Organometallic Chemistry, 2005Promo CopyTable of ContentsMagnetic Resonance Contrast Agents for Medical and Molecular Imaging. Luminescent Lanthanide Probes as Diagnostic and Therapeutic Tools. Radio-Lanthanides in Nuclear Medicine. RadioMetallo-Labeled Peptides in Tumor Diagnosis and Therapy. Cisplatin and Related Anticancer Drugs. Recent Advances and Insights. The Effect of Cytoprotective Agents in Platinum Anticancer Therapy. Antitumor Activity of Trans-Platinum Species. Polynuclear Platinum Drugs. Platinum(IV) Anticancer Complexes. Ruthenium Anticancer Drugs. Antitumor Titanium Compounds and Related Metallocenes. Gold Complexes as Antitumor Agents. Gallium and Other Main Group Metal Compounds as Antitumor Agents. Metal Ion Dependent Antibiotics in Chemotherapy.

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Book SynopsisProtein-mediated charge transport is of relevant importance in the design of protein-based electronics and in attaining an adequate level of understanding of protein functioning. This book reviews a variety of experiments devoted to the investigation of charge transport in proteins and presents a unified theoretical model to interpret macroscopic results in terms of the amino acids backbone-structure of the single protein. It aims to serve a broad audience of researchers involved in the field of electrical characterization of biological materials and in the development of new molecular devices based on proteins and also as a reference platform that surveys existing data and presents the basis for future development of a new branch of nano-electronics, which by mixing proteomics, that is, the large-scale study of proteins, particularly their structures and functions, and electronics is introduced here as proteotronics.Trade Review"This book presents the first structured approach to the new field of protein-based electronics, which has opened possibilities for the development of new concepts of nanobiosensors for health applications. It presents a solid theoretical approach which is validated by the existing experimental evidence, and will be of relevance for both young and experienced researchers who are interested in the frontier between electronics and biology."— Prof. Joan Bausells, Barcelona Microelectronics Institute (CSIC), Spain"This book presents a newly emerging discipline, proteotronics, investigating the coupling between the protein world and electronics. It opens the field of protein-based nanobiosensors that are able to bypass the complicated sequence of biological events for signal generation in e-sensing." — Prof. Nicole Jaffrezic-Renault, Institute of Analytical Chemistry, University of Lyon, France"Alfinito and her coworkers have made the very first steps of analyzing the electrical transport characteristics of the building elements of potentially important protein-based electronics. Highly recommended reading for all those who are involved with these developments and anybody who is interested in these challenging issues." — Prof. Lazlo B. Kish, Texas A&M University, USATable of ContentsPreface. Introduction. Sensing Proteins. Electrical Properties: Experiments. Electrical Properties: Theory. Bacteriorhodopsin as Testing Prototype. Survey of Other Proteins. Conclusion and Perspectives. Appendix: Computational Details. List of acronyms. Bibliography. Index.

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Book SynopsisAs computational hardware continues to develop at a rapid pace, quantitative computations are playing an increasingly essential role in the study of biomolecular systems. One of the most important challenges that the field faces is to develop the next generation of computational models that strike the proper balance of computational efficiency and accuracy, so that the problems of increasing complexity can be tackled in a systematic and physically robust manner. In particular, properly treating intermolecular interactions is fundamentally important for the reliability of all computational models. In this book, contributions by leading experts in the area of biomolecular simulations discuss cutting-edge ideas regarding effective strategies to describe many-body effects and electrostatics at quantum, classical, and coarse-grained levels. The goal of the book is to not only provide an up-to-date snapshot of the current simulation field but also stimulate exchange of ideas across different sub-fields of modern computational (bio)chemistry. The text will be a useful reference for the biomolecular simulation community and help attract talented young students into this exciting frontier of research.Trade Review"This book is a state-of-the-art report on the description of molecular energetics using force fields, which are the most critical element in computer simulations of biomolecular systems. The 16 chapters, written by leaders in the field, provide in-depth reports on all important current issues, including the representation of polarization, quantum mechanics-based force fields, and coarse-grained approaches for RNA, DNA, and membranes. This is an important reference for anyone involved in computational studies in chemistry and biology, especially those who want a deeper understanding of the underlying representations of intra- and intermolecular energetics."—Prof. William L. Jorgensen, Yale University, USATable of ContentsQM and QM/MM Methods. Polarizable continuum models for (bio)molecular electrostatics: Basic theory and recent developments for macromolecules and simulations. A modified divide-and-conquer linear-scaling quantum force field with multipolar charge densities. Explicit polarization theory. Effective fragment potential method. Quantum mechanical methods for quantifying and analyzing non-covalent interactions and for force-field development. Force field development with density-based energy decomposition analysis. Atomistic Models. Differential geometry-based solvation and electrolyte transport models for biomolecular modeling: a review. Explicit inclusion of induced polarization in atomistic force fields based on the classical Drude oscillator model. Multipolar force fields for atomistic simulations. Quantum mechanics based polarizable force field for proteins. Status of the Gaussian electrostatic model, a density-based polarizable force field. Water models: Looking forward by looking backward. Coarse-Grained Models. A physics-based coarse-grained model with electric multipoles. Coarse-grained membrane force field based on Gay–Berne potential and electric multipoles. Perspectives on the coarse-grained models of DNA. RNA coarse-grained model theory.

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Book SynopsisTrade Review"From Photon to Neuron: Light, Imaging, Vision completes a trilogy begun by Biological Physics and Physical Models of Living Systems. Those works establish Nelson as the preeminent author of textbooks at the intersection of physics and biology. . . . Nelson uses words, pictures, formulas, and code to teach students how to construct models and interpret data. His books provide a master class in how to integrate those four different approaches into a complete learning experience."---Bradley Roth, Physics Today"A thorough and sweeping tour from the fundamental physics of light to the neurobiology of the retina, with many asides into modern advances in imaging. Lavishly illustrated and carefully explained. . . . The book itself is a gem."---Sönke Johnsen, American Journal of Physics"As elegant as it is deep. A masterful tour of the science of light and vision, it goes beyond artificial boundaries between disciplines and presents all aspects of light as it appears in physics, chemistry, biology and the neural sciences. . . . In the same way that the author instructs non-physics students in some basic physics concepts and tools, he also provides physicists with accessible and very clear presentations of many biological phenomena involving light. . . . One of the most insightful, cross-disciplinary texts I have read in many years. It is mesmerising and will become a landmark in rigorous, but highly accessible interdisciplinary literature."---Luis Alvarez-Gaumé, CERN Courier

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Book SynopsisTrade Review"Hiesinger elegantly moves through a variety of topics, ranging from biological development to AI and ending with a discussion of the advances that deep neural networks have brought to the field of brain-machine interfaces."---Kamila Maria Jóźwik, Science"Hiesinger suggests that instead of looking at the brain from an endpoint perspective, we should study how information encoded in the genome is transformed to become the brain as we grow. . . . The Self-Assembling Brain is organized as a series of seminar presentations interspersed with discussions between a robotics engineer, a neuroscientist, a geneticist, and an AI researcher. The thought-provoking conversations help to understand the views and the holes of each field on topics related to the mind, the brain, intelligence, and AI."---Ben Dickson, TechTalks"For anyone interested in the brain, or AI, or any of the myriad of branches and subbranches of each, I would highly recommend this!"---Jonathan Shock, Mathemafrica

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