Regenerative medicine Books

Book SynopsisThis book presents a novel molecular description for understanding the regulatory mechanisms behind the autonomy and self-organization in biological systems. Chapters focus on defining and explaining the regulatory molecular mechanisms behind different aspects of autonomy and self-organization in the sense of autonomous coding, data processing, structure (mass) formation and energy production in a biological system. Subsequent chapters discuss the cross-talk among mechanisms of energy, and mass and information, transformation in biological systems. Other chapters focus on applications regarding therapeutic approaches in regenerative medicine. Molecular Mechanisms of Autonomy in Biological Systems is an indispensable resource for scientists and researchers in regenerative medicine, stem cell biology, molecular biology, tissue engineering, developmental biology, biochemistry, biophysics, bioinformatics, as well as big data sciences, complexity and soft computing.Table of Contents1. Relativity of Code, Energy, and Mass versus Relativi-ty of Energy and Mass2. Molecular Mechanism of Coding and Autonomous Decision Making in Biological Systems3. Molecular mechanism of self-organization in biologi-cal systems4. Molecular mechanism of self-fueling in biological systems by relativity of code, energy, and mass5. Relativity of code, energy, and mass: Molecular mechanisms of autonomy in biological systems 6. Molecular mechanism of autonomy and self-organization: an emergent concept for the future of biomedical sciences7. ConclusionIndex

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Book SynopsisThis textbook covers all the steps in manufacturing a biomedical product from bench to bedside. It specifically focuses on quality assurance and management and explains the different good practice principles in the various phases of product development as well as how to fulfill them: Good laboratory practice, good manufacturing practice and good clinical practice. It provides readers with the know-how to design biomedical experiments to ensure quality and integrity, to plan and conduct standard preclinical studies and to assure the quality of the final manufactured biomedical products. Importantly, it also addresses ethical concerns and considerations.The book discusses the guidelines and ethical considerations for preclinical and clinical studies, to allow readers to identify safety concerns regarding biomedical products and to improve pre-clinical studies for the development of better products.This textbook is a valuable guide for biomedical students (B.Sc., M.S., and Ph.D. students) in the field of molecular medicine, medical biotechnology, stem cell research and related areas, as well as for professionals such as quality control staff, tissue bankers, policy-makers and health professionals.Table of Contents

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Book SynopsisThis volume focuses on the biomedical aspects of inorganic polyphosphates, a family of unique bio-inorganic polymers.In recent years, great advances have been made in understanding the development, metabolism, and physiological role of inorganic polyphosphates. These energy-rich polymers, which consist of long chains of phosphate units, are evolutionary old molecules. The acidocalcisomes, conserved organelles from bacteria to humans, as well as the mitochondria play a central role in polyphosphate production and storage. Polyphosphates have been assigned multiple functions, some of which are closely related to medically important processes, such as blood coagulation and fibrinolysis, energy metabolism, cell cycle regulation, apoptosis, chaperon function, microvascularization, stress response, neurodegeneration and aging. The development of bioinspired polyphosphate particles, in combination with suitable hydrogel-forming polymers enabled the development of new strategies in regenerative medicine, in particular for hard and soft tissue repair, but also in drug delivery and antimicrobial defense. This book not only highlights the basic research in this area, but also discusses possible applications. Therefore, it appeals to scientists working in cell biology, biochemistry, and biomedicine and practicioners alike.Table of Contents1. Mitochondrial polyP production Prof. Dr. Andrey Y. Abramov, University College London, London, UKa.abramov@ucl.ac.uk 2. Polyphosphate in thrombosis and inflammation Prof. Dr. James H. Morrissey and Dr. Stephanie Smith, University of Michigan Medical School, Ann Arbor MI, USAjim@tf7.org or jhmorris@umich.edu3. Polyphosphate in mitochondrial energy metabolism and pathologyProf. Dr. Evgeny Pavlov, NYU College of Dentistry, New York NY, USAep37@nyu.edu4. Polyphosphate in plasma and human pathologies Prof. Dr. Felix Ruiz, Facultad de Medicina, Universidad de Cádiz, Cádiz, Spainfelix.ruiz@uca.es5. PolyP in neurodegeneration and agingProf. Dr. Maria E. Solesio, Rutgers University, Camden NJ, USAm.solesio@rutgers.edu6. Effects of polyphosphate on function of leukocytesDr. Patrick Suess, University of Michigan Medical School, Ann Arbor MI, USApsuess@med.umich.edu7. PolyP and Vtc complexProf. Dr. Andreas Mayer, University of Lausanne, Epalinges, Switzerlandandreas.mayer@unil.ch8. PolyP in antiviral protectionProf. Dr. Dr. h.c. Werner E. G. Müller, Prof. Dr. Xiaohong Wang, Prof. Dr. Dr. Heinz C. Schröder, University Medical Center of Johannes Gutenberg University Mainzwmueller@uni-mainz.de9. Polyphosphate in biomimetic implant materialsProf. Dr. Dr. Heinz C. Schröder, Prof. Dr. Xiaohong Wang, Prof. Dr. Dr. h.c. Werner E. G. Müller, University Medical Center of Johannes Gutenberg University Mainzwmueller@uni-mainz.de

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Book Synopsis In diesem Band berichten die Autoren aus führenden Labors, die sich mit Stammzelltheranostik beschäftigen, über die neuesten Fortschritte auf dem Gebiet der Stammzellforschung. Das Buch befasst sich mit vielen Aspekten der stammzellbasierten Therapie und den Fortschritten in der Stammzelltherapie bei Leber-, Augen- und Herz-Kreislauf-Erkrankungen sowie bei Krebs. Dieser Band ist eine Fortsetzung der von Prof. Khawaja Husnain Haider bereits herausgegebenen Bücher zur stammzellbasierten Therapienostik. Es ist ein ideales Buch für Forscher, die sich mit der Entwicklung von Arzneimitteln sowie mit regenerativer Medizin und stammzellbasierter Therapie beschäftigen. Die sekundäre Zielgruppe umfasst Medizinstudenten, Ärzte, Zellpharmakologen, die Arzneimittelindustrie und Forscher, die Stammzellen als Ex-vivo-Krankheitsmodelle für die Arzneimittelentwicklung verwenden. Table of ContentsMikro-Elektroden-Arrays: Ein wertvolles Instrument zur Analyse von Kardiomyozyten aus Stammzellen2. CD34+ STAMMZELLEN UND REGENERATIVE MEDIZIN 3. Mesenchymal-hämatopoetische Stammzellachse: Anwendungen für die Induktion von hämatopoetischem Chimärismus und Therapien für maligne Erkrankungen 4. Aus mesenchymalen Stammzellen gewonnenes Sekretom: ein neues Mittel zur Behandlung von Autoimmun- und Entzündungskrankheiten 5. Regenerative Herztherapie bei Diabetes: Herausforderungen und potenzielle Therapeutika 6. Makrophagenreaktion auf Biomaterialien bei kardiovaskulären Anwendungen 7. Entwicklung von Stammzellen in der kardio-regenerativen Therapie 8. Regeneration des Herzens auf der Grundlage von Stammzellen: Kann man optimistisch in die Zukunft blicken? 9. Dentale mesenchymale Stamm-/Progenitorzellen: Eine neue Perspektive für die regenerative Medizin 10. Stammzellbasiertes Tissue Engineering für funktionalen Schmelz und Dentin/Pulp-Komplex: eine mögliche Alternative zu restaurativen Therapien 11. Zell- und stammzellbasierte Therapien für Leberdefekte: Jüngste Fortschritte und künftige Strategien 12. Stammzellen: eine erneuerbare Quelle für β-Zellen der Bauchspeicheldrüse und die Zukunft der Diabetesbehandlung 13. Induzierte pluripotente Stammzellen in der pädiatrischen Forschung und klinischen Umsetzung 14. Reifung von aus pluripotenten Stammzellen gewonnenen Kardiomyozyten und Zukunftsperspektiven für die regenerative Medizin 15. Verfügbarkeit von pluripotenten Stammzellen aus normalen Zellen in der Krebsforschung

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Book SynopsisThis edited collection deals with the structure-property relationships and biomedical applications of carboxymethyl chitosan derivatives in different fields. Readers will detailed overview of the preparatory methods involved in the derivatives of carboxymethyl chitosan and its interaction with metal ions. The chapters provide a detailed overview of the different types of carboxymethyl chitosan derivatives, including the preparatory methods involved, the interactions with metal ions, and the antimicrobial activities. These different forms of carboxymethyl chitosan derivatives are found to be potentially used in food packaging, in enhancing saltiness, as biosensors, and also as wound dressing. Chapters are also devoted to the fabrication and biomedical applications of carboxymethyl chitosan derivatives-based nanofibers as well as the interaction of carboxymethyl chitosan with blood in blood clotting and the underlying mechanism. Contributing authors additionally explore topics related to carboxymethyl chitosan-based hydrogels, films, scaffolds, fibers, and composites. Finally, this volume presents the current challenges in developing biomedical products based on carboxymethyl chitosan derivatives. This book will be of interest not only to chemists, but to all scientists working in the fields of material/environmental science, biological science, and biomaterials. These chapters are great resources for any researcher who works with structure-property relationships, biological interactions, and the applications of carboxymethyl chitosan derivatives in different biomedical fields.Table of ContentsIntroductory Aspects of Carboxymethyl Chitosan derivatives.- Preparation of Different Types of Carboxymethyl Chitosan Derivatives.- Carboxymethyl Chitosan Derivatives and Its Interaction with Metal Ions.- Antimicrobial Properties of Carboxymetyl Chitosan Based Derivatives.- Synthesis of Carboxymethyl Chitosan Derivatives Based Hydrogels and Its Applications.- Synthesis of Carboxymethyl Chitosan Derivatives in Biosensing.- Carboxymethyl Chitosan Based Derivatives in Blood Clotting and Its Mechanism.- Electrospinning of Carboxymethyl Chitosan Based Derivatives and Its applications.- Carboxymethyl Chitosan Based Derivatives in Diagnosis & Targeting.- Carboxymethyl Chitosan Derivatives for Drug and Vaccine Delivery: An overview.- Carboxymethyl Chitosan Derivatives in Tissue Engineering.- Functionalized Carboxymethyl Chitosan Based Derivatives in Wound Healing.

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Book SynopsisThis reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.Table of ContentsSources.- Primary cells.- Chondrocytes.- Muscle cells.- ß-cells.- Schwann cells.- Cell lines for test systems.- Immortalized primary cells.- STEM.- Bone marrow derived.- Placenta derived cells.- Amnion.- in toto.- Placenta / Chorion.- Cord/Wharton cells.- Amniotic fluid cells.- Adipose derived cells.- Isolation enzymatic.- SVF.- Isolation non-enzymatic.- SVF.- ASC.- Perivascular / Angiogenic cells origin.- Multiple Sources.- Blood.- Olfactory mucosa.- Tendon.- iPS, ES or Transdifferentiation.- ESC.- Many sources and routes to iPS.- Needs for clinical application.- Tools for mechanistic studies.- HaploBank.- Autologous or Allogeneic.- Preconditioning.- Sorting.- Biophysical.- Chemical.- Transfection.- Aggregation.- Sheets.- Microaggregates.- Two level approach.- Modulation.- Growth factors.- miRNA.- Epigenetic approaches.- Biophysical.- Two level approach.- "Student-Teacher".- Coculture.- "Student-School".- Environmental Cues.- Application Routes.- Systemic.- Local.- Endogenous catching.- SDF-1-CXCR4 axis.- Cell Tracking.- Action.- Cell differentiation.- Cell-cell contact.- Secretome.- Learning from embryogenesis / evolution.- Basics of amphibian self regeneration.

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Book SynopsisThis book provides readers a fundamental insight into the basic properties of the pharmaceutical agents used in the treatment of osteoporosis. It provides insight into mechanisms of action, updated information on clinical utility, and possible side effects associated with the use of these pharmaceutical agents. In particular, it highlights the use of two monoclonal antibodies romosozumab and denosumab in activating osteoblast differentiation and inhibiting osteoclasts. It also discusses two anabolic pharmaceutical agents, teriparatide and abaloparatide to treat osteoporosis. They have been shown to reduce the incidence of non-vertebral and vertebral fractures significantly after they were administered to patients daily as subcutaneous injections. The content of this book caters to researchers, scientists, and clinical practitioners who are interested in the treatment of osteoporosis using pharmaceutical agents.Table of Contents

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