Medicinal chemistry Books
Penguin Books Ltd Periodic Tales
Book SynopsisTHE PHENOMENAL SUNDAY TIMES BESTSELLER ''Science writing at its best. If only chemistry had been like this at school'' Matt Ridley ____________________ Everything in the universe is made of them, including you. Like you, the elements have personalities, attitudes, talents, shortcomings, stories rich with meaning. Here you''ll meet iron that rains from the heavens and noble gases that light the way to vice. You''ll learn how lead can tell your future while zinc may one day line your coffin. You''ll discover what connects the bones in your body with the Whitehouse in Washington, the glow of a streetlamp with the salt on your dinner table. Unlocking their astonishing secrets and colourful pasts, Periodic Tales is a voyage of wonder and discovery, showing that their stories are inextricable from the stories of our own lives. ____________________ ''A love letter to the chemical elements. Aldersey-Williams is full of good stories and he knows how to tell them well'' Sunday Telegraph ''The history, science, art, literature and everyday applications of all the elements from aluminium to zinc'' The Times ''Great fun to read and an endless fund of unlikely and improbable anecdotes'' Financial TimesTrade ReviewScience writing at its best ... fascinating and beautiful ... if only chemistry had been like this at school ... to meander through the periodic table with him ... is like going round a zoo with Gerald Durrell ... a rich compilation of delicious tales, but it offers greater rewards, too -- Matt RidleyImmensely engaging and continually makes one sit up in surprise * Sunday Times *Splendid ... enjoyable and polished * Observer *Full of good stories and he knows how to tell them well ... an agreeable jumble of anecdote, reflection and information * Sunday Telegraph *Great fun to read and an endless fund of unlikely and improbable anecdotes ... sharp and often witty * Financial Times *A joyous romp through the chemical elements * Today, BBC Radio 4 *Not only a cultural history of the elements, it is also a lament to the loss of science as a hobby * Economist *A flashily brainy book, crammed with literary references and held together by a personal quest to collect as many elements as possible * Telegraph *'Elements are fun' is the essential premise of Hugh Aldersey-Williams's new book and by heck he's right ... Aldersey-Williams mourns the fact chemistry isn't really sexy any more; Periodic Tales is a step towards it getting its mojo back * Metro **** *Imaginative and fun ... almost every page yields a nugget * Nature *
£11.69
Springer-Verlag New York Inc. Advanced Organic Chemistry
Book SynopsisAlkylation of Enolates and Other Carbon Nucleophiles.- Reactions of Carbon Nucleophiles with Carbonyl Compounds.- Functional Group Interconversion by Substitution, Including Protection and Deprotection.- Electrophilic Additions to Carbon-Carbon Multiple Bonds.- Reduction of Carbon-Carbon Multiple Bonds, Carbonyl Groups, and Other Functional Groups.- Concerted Cycloadditions, Unimolecular Rearrangements, and Thermal Eliminations.- Organometallic Compounds of Group I and II Metals.- Reactions Involving Transition Metals.- Carbon-Carbon Bond-Forming Reactions of Compounds of Boron, Silicon, and Tin.- Reactions Involving Carbocations, Carbenes, and Radicals as Reactive Intermediates.- Aromatic Substitution Reactions.- Oxidations.- Multistep Syntheses.Trade ReviewFrom the reviews of the fifth edition: "Advanced Organic Chemistry … the well-known textbook for graduate students – has now appeared in a 5th edition. … Carey & Sundberg will be interesting to all students who seek a detailed understanding of organic chemistry, and who wish to refresh and embellish their existing knowledge. On the strength of the scope and quality of the explanations, this pair of texts is recommended for use as the resource of first resort for specific research questions in one’s later career." (www.organische-chemie.ch, January, 2008)Table of ContentsAlkylation of Enolates and Other Carbon Nucleophiles.- Reactions of Carbon Nucleophiles with Carbonyl Compounds.- Functional Group Interconversion by Substitution, Including Protection and Deprotection.- Electrophilic Additions to Carbon-Carbon Multiple Bonds.- Reduction of Carbon-Carbon Multiple Bonds, Carbonyl Groups, and Other Functional Groups.- Concerted Cycloadditions, Unimolecular Rearrangements, and Thermal Eliminations.- Organometallic Compounds of Group I and II Metals.- Reactions Involving Transition Metals.- Carbon-Carbon Bond-Forming Reactions of Compounds of Boron, Silicon, and Tin.- Reactions Involving Carbocations, Carbenes, and Radicals as Reactive Intermediates.- Aromatic Substitution Reactions.- Oxidations.- Multistep Syntheses.
£49.49
Oxford University Press An Introduction to Medicinal Chemistry
Book SynopsisThe market-leader in medicinal chemistry: clear, supportive, and practical. It helps students to effortlessly make the link from theory to real-life applications using practical and focused coverage alongside a package of supportive online resources.Trade ReviewThe best general undergraduate textbook on medicinal chemistry. This new edition retains the accessible style of writing, but provides important updates on the topics. * Dr Mark Ashton, School of Pharmacy, Newcastle University, UK *I read this masterpiece to build a strong knowledge of medicinal chemistry and it has helped me a lot. I would definitely recommend it to others. Detailed explanations of enzyme-substrate interactions and much more are very useful. * Jinkal Gondaria, MChem student, Manchester Metropolitan University, UK *A very useful medical chemistry book and teaching tool. Great learning resources and easy to digest content. * Dr Silvia M.M.A. Pereira-Lima, Department of Chemistry, University of Minho, Portugal *Table of Contents1: Drugs and Drug Targets 2: Protein Structure and Function 3: Enzymes: Structure and Function 4: Receptors: Structure and Function 5: Receptors and Signal Transduction 6: Nucleic Acids: Structure and Function 7: Enzymes as Drug Targets 8: Receptors as Drug Targets 9: Nucleic Acids as Drug Targets 10: Miscellaneous Drug Targets 11: Pharmacokinetics and Related Topics Case Study 1: Statins 12: Drug Discovery: Finding a Lead 13: Drug Design: Optimizing Target Interactions 14: Drug Design: Optimizing Access to the Target 15: Getting the Drug to Market Case Study 2: The Design of ACE Inhibitors Case Study 3: Artemisinin and Related Antimalarial Drugs Case Study 4: The Design of Oxamni Case Study 5: Fosfidomycin as an Antimalarial Agent 16: Combinatorial and Parallel Synthesis 17: In Silico Drug Design 18: Quantitative Structure-Activity Relationships Case Study 6: De Novo Design of a Thymidylate Synthase Inhibitor 19: Antibacterial Agents 20: Antiviral Agents 21: Anticancer Agents 22: Protein Kinase Inhibitors as Anticancer Agents 23: Antibodies and Other Biologics 24: Cholinergics, Anticholinergics, and Anticholinestarases 25: Drugs Acting on the Adrenergic Nervous System 26: The Opioid Analgesics 27: Anti-Ulcer Agents 28: Cardiovascular Drugs Case Study 7: Steroidal Anti-Inflammatory Agents Case Study 8: Design of a Novel Antidepressant Case Study 9: The Design and Development Of Aliskiren Case Study 10: Factor Xa Inhibitors Case Study 11: Reversible Inhibitors of HCV NS-34A Protease
£50.34
Springer-Verlag New York Inc. Advanced Organic Chemistry
Book Synopsis1: Chemical Bonding and Molecular Structure.- 2: Stereochemistry, Conformation, and Stereoselectivity.- 3: Structural Effects on Stability and Reactivity.- 4: Nucleophilic Substitution.- 5: Polar Addition and Elimination Reactions.- 6: Carbanions and Other Carbon Nucleophiles.- 7: Addition, Condensation and Substitution Reactions of Carbonyl Compounds.- 8: Aromaticity.- Aromatic Substitution.- 9: Concerted Pericyclic Reactions.- 10: Free Radical Reactions.- 11: Photochemistry.Trade ReviewFrom the reviews of the fifth edition:“Carey and Sundberg had written the most detailed and briliant account in the subject of organic chemistry. … The book provides an abundance of reaction examples organized in schemes. It makes studying very effective and helpful. … Advanced undergraduates and graduate students will welcome this new edition and the depth of materials covered.” (Philosophy, Religion and Science Book Reviews, bookinspections.wordpress.com, May, 2014)Table of ContentsChemical Bonding and Molecular Structure.- Stereochemistry, Conformation, and Stereoselectivity.- Structural Effects on Stability and Reactivity.- Nucleophilic Substitution.- Polar Addition and Elimination Reactions.- Carbanions and Other Carbon Nucleophiles.- Addition, Condensation and Substitution Reactions of Carbonyl Compounds.- Aromaticity.- Aromatic Substitution.- Concerted Pericyclic Reactions.- Free Radical Reactions.- Photochemistry.
£71.99
Springer Laboratory Techniques in Thrombosis a Manual
Book SynopsisThe first edition of this manual appeared in 1992 and was entitled ECAT Assay Procedures. It was the result of a unique cooperation between experts brought together by the European Concerted Action on Thrombosis and Disabilities (ECAT). The Concerted Action was at that time under the auspices of the Commission of the European Union. The second edition, like the first edition, deals with diagnostic tests within the field of thrombosis. However, the second edition has a broader scope because it is no longer limited by the frontiers of ECAT. Experts allover the world, in and outside ECAT, have contributed to this edition. The editors are very grateful for their contributions. The need for a new edition is obvious. Since 1992 new assays have been introduced for research, diagnosis, and therapy of thrombosis; for other assays improvements have been suggested, while a few others becameTrade Review`The objective towards standardization is largely met, since world experts on each assay collaborated to evaluate and compare the available methodologies and point to the advantages and disadvantages of each one. This book is written for clinical thrombosis and hemostasis laboratorians. Another attractive feature is the degree of expertise recruited to produce these critical summaries of existing methodologies. This book is a long overdue update of the first edition in view of the multitude of newly developed methodologies and the number of manufacturers involved.' Demetra D. Callas, Loyola University Medical Center in Doody Publishing Inc. Table of ContentsList of Contributors. Nomenclature of Haemostasis Factors. 1. Introduction to Laboratory Assays in Haemostasis and Thrombosis; J.Gram, J. Jespersen. 2. Good Medical Laboratory Services - Guidelines; J.-C. Libeer. 3. Blood Collection and Sample Preparation: Pre-analytical Variation; I.D. Walker. 4. Quality Assessment of Haemostatic Assays and External Quality Assessment Schemes; T.A.L. Woods, et al. 5. Activated Partial Thromboplastin Time (APTT); L. Poller. 6. Prothrombin Time (PT); L. Poller. 7. Endogenous Thrombin Potential; H.C. Hemker, S. Béguin. 8. Fibrinogen; M.P.M. de Maat, et al.9. Activated Factor VII; J.H. Morrissey. 10. Factor VII Activity and Antigen; G. Mariani, et al. 11. Factor VIII Clotting Activity; P.M. Mannucci, A. Tripodi. 12. Von Willebrand Factor; P.M. Mannucci, R. Coppola. 13. Antithrombin Activity and Antigen; J. Conard. 14. Protein C Activity and Antigen; R.M. Bertina. 15. Protein S Antigen; R.M. Bertina. 16. Protein S Activity Assays; E.M. Faioni. 17. Activated Protein C (APC) Resistance; A. Tripodi. 18. Tissue Factor Pathway Inhibitor (TFPI); P.M. Sandset. 19. Lupus Anticoagulant; D.A. Triplett. 20. Heparin Cofactor II; S.J. Bauman, F.C. Church. 21. Fibrinopeptide A (FPA); A. Haeberli. 22. Thrombin-Antithrombin (TAT) Complexes; J. Harenberg. 23. Prothrombin Fragment F 1+ 2; A. Haeberli. 24. Plasma Tissue-Type Plasminogen Activator (t-PA) Activity; C. Kluft, et al. 25. Tissue Type Plasminogen Activator Antigen (t-PA Ag); M.Ch. Alessi, I. Juhan-Vague. 26. Plasminogen Activator Inhibitor-1(PAI-1) Antigen; P.J. Declerk. 27. Plasminogen Activity; P.J. Gaffney. 28. Plasma Plasmin Inhibitor* Activity (*Previously &agr;2-Antiplasmin); C. Kluft, P. Meyer. 29. Plasmin-&agr;2-Antiplasmin Complexes (Plasmin-Plasmin Inhibitor Complexes); E. Hattey, et al. 30. Soluble Fibrin and Degradation Products of Fibrinogen (FgDP), Fibrin (FbDP;D-dimer) and Total of FgDP and FbDP (TDP); W. Nieuwenhuizen, R. Bos. 31. Venous Occlusion Test in Fibrinolysis Assays; J. Jespersen. 32. List of Manufacturers. Index.
£170.99
Pharmaceutical Press Essentials of Pharmaceutical Chemistry
Book SynopsisEssentials of Pharmaceutical Chemistry is an introduction to pharmaceutical chemistry for undergraduate pharmacy, chemistry and medicinal chemistry students. It covers all of the core material necessary to provide an understanding of the basic chemistry of drug molecules.Trade Review "...Donald Cairns is a well-known educator, mentor, and researcher...this is an excellent resource for pharmacy students taking pharmaceutical chemistry and for individuals who intend to pursue a career in the pharmaceutical industry...Readers will find this as a useful reference." Rahmat M Talukder, Ph.D.,Doody's Notes, May 2012. -- Rahmat M Talukder * Doody's Notes *"This is a great book detailing the basic chemistry of drugs...Throughout the book there are problems that can be worked, and it includes the answers at the end of the book. It is very easy-to-read and has very good graphics to support the discussions. In addition to being a good text, it is a good refresher for those that would like to review this topic."Compounding Today, 27 Jan 2012. * Compounding Today *Table of Contents1. Chemistry of Acids and Bases; 2. Partition Coefficient and Biopharmacy; 3. Physicochemical Properties of Drugs; 4. Stereochemistry; 5. Drug Metabolism; 6. Volumetric Analysis of Drugs; 7. Analytical Spectroscopy; 8. Chromatographic Methods of Analysis; 9. Stability of Drugs and Medicines; 10. Kinetics of Drug Stability; 11. Licensing of Drugs and the British Pharmacopoeia; 12. Medicinal Chemistry - the Science of Rational Drug Design; 13. Answers to Problems
£38.70
Taylor & Francis Ltd Aromatic and Medicinal Plants of Drylands and
Book SynopsisThe description and analysis of the Mexican and other countries desertic plants from the point of view of their use in traditional medicine and their potential use in integrative medicine is the overall theme of this book. Aromatic and Medicinal Plants of Drylands and Deserts: Ecology, Ethnobiology and Potential Uses describes the historic use of drylands plants, botanical and geological classification, also describes the endemic plants used in traditional medicine, going through the most relevant aspects of biomedicine and integrative medicine. The chemical and bioactive compounds from desertic medicinal and aromatic plants and the analytic techniques to determine chemical and bioactive compounds from the medicinal and aromatic plants are reviewed. Ethnobiology is detailed in the present book as well as the importance of the integrative medicine for the ancient and actual cultures. The book represents an effort to keep the ethnobiological knowledge of communities for the use of traTable of ContentsPrefaceChapter 1 Introduction to plant taxonomy: vascular and non-vascular plants with medicinal use. Muro-Pérez G., Sánchez-Salas J., Cano-Villegas O., López-García R., Valenzuela-Núñez L. M.Chapter 2 Mexican desertic medicinal plants: biology, ecology, and distribution. Hernández-Herrera J. A., Valenzuela-Núñez L. M., Encina-Domínguez J. A., Martínez-Sifuentes A. R., Lara-Reimers E. A., Navarrete-Molina C.Chapter 3 Mexican Desert: Health and biotechnological properties potential of some cacti species (Cactaceae). Trujillo J., Pérez-Miranda S., Ramírez-Hernández A., Muñiz-Ramírez A., García-Campoy A.H., Ramírez-Rodríguez Y. Chapter 4 Potential of plants from the arid zone of Coahuila in Mexico for the extraction of essential oils. Solís-Quiroz O. S., González-Machado A. C., Aguirre-Joya J. A., Aguillón-Gutiérrez D. R., Ramírez-Moreno A., Torres-León C.Chapter 5 Ethnopharmacology of important Aromatic Medicinal plants of the Caatinga, Northeastern Brazil. Olaitan-Balogun S., Medeiros-Bandeira M. A., do Nascimento-Magalhães K., Lima-Soares I. Chapter 6 Plants of the Chihuahuan Semi-desert for the Control of Phytopathogens. Cándido-del Toro C. A., Arredondo-Valdés R., Govea-Salas M., Anguiano-Cabello J. C., Segura-Ceniceros E. P., Ramos-González R., Ascacio-Valdés J. A., Laredo Alcalá E. I., Iliná A.Chapter 7 Phytochemical compounds from desert plants to management of plant-parasitic nematodes. Marco Tucuch-Pérez A., Arredondo-Valdés R., Hernández-Castillo F. D., Ochoa-Fuentes Y. M., Laredo Alcalá E. I., Anguiano-Cabello J. C.Chapter 8 Plant phytochemicals from the Chihuahuan semi-desert with possible herbicidal actions. Barroso-Ake A. C., Arredondo-Valdés R., Ramos-González R., Laredo-Alcalá E. I., Aguilar-González C. N., Ascacio-Valdés J. A., Govea-Salas M., Iliná A., Tucuh-Peréz M. A.Chapter 9 ¬Chemical and bioactive compounds from Mexican desertic medicinal plants. López-Romero J. C., Torres-Moreno H., Ireta-Paredes A. R., Charles-Rodríguez A. V., Flores-López M. L.Chapter 10 Edible coating based on chia (Salvia hispanica L.) functionalized with Rhus microphylla fruit extract to improve the cucumber (Cucumis sativus L.) shelf life. Charles-Rodríguez AV., Reyes-de la Luz M., Guía-García J. L., Peña-Ramos F.M., Robledo-Olivo A., Hench-Cabrera A. F., Flores-López M. L.Chapter 11 Larrea tridentata: bioactive compounds, biological activities and its potential use in phytopharmaceuticals improvement. López-Romero J. C., Torres-Moreno H, Rodríguez-Martínez K. L., Suárez-García A. del C., Beltrán-Martínez M. E., García-Dávila J.Chapter 12 Toxicological aspects of medicinal plants that growth in drylands and polluted environments. Pérez-Morales R., Téllez López M. A., Olivas Calderón E. H., González-Zamora A.
£147.25
John Wiley & Sons Inc Disaster Victim Identification in the 21st
Book SynopsisA comprehensive examination of all critical aspects of Disaster Victim Identification (DVI) As the frequency of both natural and man-made mass fatality disasters increases worldwide, the establishment of clear standards and best practices within the field of Disaster Victim identification (DVI) is of vital importance. Whereas most countries assign jurisdiction to law enforcement agencies following Interpol guidelines, DVI is the responsibility of the medical examiner and coroner in the United States. Disaster Victim Identification in the 21st Century is the first book of its kind to directly address the needs of DVI practitioners in the United States, covering the full spectrum of DVI from traditional methods such as fingerprints, odontology, and anthropology to advanced DNA identification technology. Approaching DVI from three perspectivesacademic, government, and private industrythis comprehensive volume examines the history and current state of the discipline, Table of ContentsAbout the Editors xv Notes on the Contributors xvii Preface xxi Series Preface xxiii 1 Introduction 1John A Williams and Victor W Weedn 1.1 Introduction 1 1.2 This Book 3 2 Historical Background 7Victor W Weedn 2.1 History of Mass Disasters 7 2.2 Early History of Mass Disaster Response 14 2.2.1 The Portsmouth Christmas Fires and 1803 Portsmouth Federal Disaster Relief 16 2.2.2 The 1835 Great Fire of New York City 16 2.2.3 1865 Sultana Explosion 18 2.2.4 The 1871 Fires 18 2.2.5 American Red Cross (ARC) 19 2.2.6 1889 Johnstown Flood 19 2.2.7 1899 San Ciriaco Hurricane 20 2.2.8 1900 Galveston Storm 20 2.2.9 1906 San Francisco Earthquake 21 2.2.10 1911 Triangle Shirtwaist Fire 21 2.2.11 1912 Sinking of Titanic 22 2.2.12 1918 Spanish Flu Pandemic 22 2.2.13 1921–22 Russian (Povolzhye) Famine 23 2.2.14 1927 Mississippi River Flood 24 2.3 1930s and 1940s Federal Disaster Relief Legislation 24 2.3.1 World War II Civilian Preparedness and Emergency Assets 25 2.3.2 Post WWII Federal Disaster Relief Legislation 25 2.3.3 Civil Defense Act of 1950 (P.L 81-920) 26 2.3.4 Federal Disaster Relief Act of 1950 (P.L 81-875) 26 2.4 1950s Federal Disaster Relief 28 2.5 1960s Beginnings 28 2.5.1 1960 Hurricane Donna 29 2.5.2 1961 Hurricane Carla 29 2.5.3 1962 Ash Wednesday Storm 29 2.5.4 1964 Great Alaskan Earthquake 30 2.5.5 1960s Federal Activism in the Wake of the Alaskan Earthquake 30 2.5.6 1965 Palm Sunday Tornado Outbreak 30 2.5.7 1965 Hurricane Betsy 31 2.5.8 Disaster Relief Act of 1966 31 2.5.9 1968 National Flood Insurance 31 2.5.10 1969 Hurricane Camille 32 2.6 Disaster Relief Acts of 1969 and 1970 32 2.6.1 1971 San Fernando (Sylmar) Earthquake 32 2.6.2 1972 Hurricane Agnes 33 2.6.3 1974 Super Outbreak 33 2.6.4 Disaster Relief Act Amendments of 1974 33 2.7 National Emergencies Act of 1976 34 2.8 National Earthquake Hazards Reduction Program (NEHRP) of 1977 34 2.9 1979 Executive Orders 12127 & 12148 – Federal Emergency Management Agency (FEMA) 35 2.9.1 1979 Three Mile Island (TMI) Nuclear Accident 36 2.9.2 1980 Mount St Helens Volcanic Eruption 37 2.10 Disaster Relief and Emergency Assistance Act of 1988 (The Stafford Act) 37 2.10.1 FEMA under President George H W Bush (1989–1993) 38 2.10.2 1989 Exxon Valdez Oil Spill 38 2.10.3 1989 Hurricane Hugo 39 2.10.4 1989 Loma Prieta Earthquake 39 2.11 1992 Federal Response Plan (FRP) 40 2.11.1 1992 Hurricane Andrew 40 2.11.2 1992 Hurricane Iniki 41 2.12 FEMA under President William J Clinton (1993–2001) 41 2.12.1 1993 Midwest Floods 42 2.12.2 1994 Northridge Earthquake 42 2.12.3 1995 Oklahoma City Bombing 42 2.13 1996 EMAC 43 2.14 FEMA under President George W Bush (2001–2009) 43 2.14.1 2001 Al Qaeda 9/11 Terrorist Attacks 44 2.15 Department of Homeland Security (DHS) 45 2.15.1 2005 Hurricane Katrina 47 2.16 Post-Katrina Emergency Management Reform Act of 2006 (PKEMRA) 48 2.17 2008 National Response Framework (NRF) 49 2.18 2011 National Disaster Recovery Framework 50 2.18.1 2012 Hurricane Sandy 50 2.18.2 Sandy Recovery Improvement Act of 2013 (SRIA) 50 2.18.3 2017 Hurricane Harvey 51 2.18.4 2017 Hurricane Maria 51 2.19 The Disaster Recovery Reform Act of 2018 (DRRA) 52 2.20 2020 COVID-19 Pandemic 52 2.21 Summary of Federal Disaster Response 53 2.22 History of Disaster Victim Identification 54 2.22.1 Scientific Methods of Identification 55 2.22.2 Military Identification Efforts 59 2.22.3 Fbi Dvi Squad 61 2.22.4 Interpol 61 2.22.5 Other International Guidance 63 2.22.6 Disaster Mortuary Operations Response Team (DMORT) 64 2.22.7 National Association of Medical Examiners 65 2.22.9 US Standards Setting Efforts 66 2.22.8 Federal Direction 65 2.23 Conclusion 68 References 68 3 Quality Assurance in Disaster Victim Identification: The Case for Standards 93Jason M Wiersema and Michal L Pierce 3.1 Introduction 93 3.2 The Need for Standards in MDI 94 3.3 The Need for Standards in DVI 96 3.4 History of Standards Development in DVI 98 3.5 Organization of Scientific Area Committees (OSAC) 99 3.6 Discussion 100 3.7 Adoption of Standards 102 3.8 Conclusion 104 References 104 4 Medical Examiners, Coroners, and Public and Private Agencies 107John A Williams and Jason Wiersema 4.1 Introduction 107 4.2 The Medical Examiner/Coroner System 109 4.3 The US Federal Government and Mass Disasters 111 4.4 Disaster Mortuary Operational Response Team 115 4.5 Transportation Disaster Response 121 4.6 State Reponses to Mass Fatalities 122 4.7 The Private Sector 123 4.8 Summary 123 References 124 5 DVI Morgue Operations 127John A Williams 5.1 Introduction 127 5.2 DVI Morgue Considerations 127 5.2.1 Morgue Site Selection 128 5.2.2 Incident Command System 129 5.3 Workflow in the DVI Morgue 131 5.4 DVI Morgue Stations 135 5.4.1 Non-forensic Stations 135 5.4.2 Forensic Stations 139 5.5 Information Resource Center 141 5.6 Identification and Reconciliation 142 5.7 Summary 143 References 143 6 Forensic Odontology and Disaster Victim Identification 145Kenneth W Aschheim 6.1 Introduction 145 6.2 Methods of Identification of an Individual 145 6.2.1 Non-Dental Methods of Identification 145 6.2.2 Dental Identification 146 6.3 Theoretical Basis for Comparative Dental Analysis 147 6.3.1 Basic Theory 147 6.3.2 The 32 Teeth Concept 149 6.3.3 Logical Direction of Change 151 6.3.4 Comparison Discrepancies 151 6.3.5 Concordant Features 151 6.4 The Antemortem Dental Record 153 6.4.1 Tooth Numbering Systems 154 6.5 Laws Governing the Transfer of Protected Dental Information 155 6.5.1 Electronic Dental Record 156 6.5.2 Issues Concerning Dental Data 156 6.6 The Postmortem Dental Record 156 6.7 The Dental Autopsy 157 6.7.1 Visible Light Fluorescence 159 6.7.2 Craniofacial Dissection 159 6.7.3 Antemortem Radiographs 160 6.7.4 Postmortem Radiographs 161 6.7.5 Types of Imaging Devices 161 6.7.5.1 Film 161 6.7.5.2 Phosphorus Storage Plates (PSP) 162 6.7.6 Digital Sensors 162 6.7.7 Radiographic Sources 162 6.7.8 Types of Dental Radiographs 163 6.7.8.1 Intraoral Radiographs 163 6.7.8.2 Extraoral Radiographs 164 6.7.9 Radiographic Guidelines 166 6.8 Intraoral and Extraoral Photographs 167 6.8.1 Postmortem Photographs 168 6.9 Study Casts 169 6.10 Denture Labeling 170 6.11 Dental Age Assessment 171 6.12 Characterization of Dental Materials 172 6.13 Reconciliation 172 6.13.1 Source Conclusions 172 6.13.2 Serial Unmasking 173 6.13.3 Criteria for Comparison and Reconciliation 173 6.13.4 Reporting 174 6.13.5 Terminology 174 6.14 Assembling the Forensic Odontology Team 174 6.14.1 Leadership Team 176 6.14.2 Administration Team 176 6.14.3 Site Assessment Team 177 6.14.4 Antemortem Team 177 6.14.5 Postmortem Team 178 6.14.6 Coding Team 178 6.14.7 Information Technology Team 178 6.14.8 Photographic Team 178 6.14.9 Reconciliation (Comparison) Team 179 6.14.10 Identification Review Board (IRB) 179 6.15 Computer-Assisted Dental Identification 179 6.15.1 Computer Assisted Post-Mortem Identification (CAPMI) 180 6.15.2 WinID3 181 6.15.3 Uvis/Udim 183 6.15.4 Dvi System International 186 6.15.5 OdontoSearch 187 6.16 Ethical Considerations 188 6.17 Demobilization and After-Action Reports 189 6.17.1 Demobilization 189 6.17.2 Preservation of Dental Data 189 6.17.2.1 Preservation of Antemortem Dental Data 189 6.17.2.2 Preservation of Postmortem Dental Data 190 6.17.3 Post-Action Follow-Up 190 6.17.4 Planning and Training 190 6.18 Conclusion 191 References 191 7 Fingerprints and DVI 195Bryan Johnson 7.1 Introduction 195 7.2 Role of Fingerprints in DVI 197 7.3 The DVI Process and Fingerprints 198 7.4 Postmortem Fingerprinting Station 200 7.5 Personnel and Postmortem Fingerprinting 203 7.6 Postmortem Fingerprinting Process 204 7.6.1 Inspection and Cleansing 205 7.6.2 Rehydration 205 7.6.2.1 Macerated Remains 209 7.6.2.1.1 Tissue Injection 209 7.6.2.1.2 Degloving 210 7.6.2.1.3 Boiling Method 210 7.6.2.2 Thermal Modification (Charred/burned Skin) 213 7.6.2.2.1 Tendon Release 214 7.6.2.2.2 Break and Twist Method 214 7.6.2.3 Desiccation (Mummification) 215 7.6.2.3.1 Sodium Hydroxide Reconditioning 217 7.6.2.3.2 Ammonium Hydroxide Reconditioning 217 7.6.2.3.3 Detergent Soaking Reconditioning 218 7.6.3 Collecting PM Prints 219 7.6.3.1 Digital Capture 219 7.6.3.2 Powder and Adhesive Lifters 220 7.6.3.3 Ink and Paper 222 7.6.3.4 Casting 224 7.6.3.5 Photography 225 7.7 Searching/AM Records 226 7.7.1 Database Searches 227 7.7.2 AM Purported Knowns 228 7.7.3 Palm Prints and Footprints 229 7.8 Conclusion 230 References 231 8 DNA Technology and the Future of Disaster Victim Identification 233Taylor M Dickerson III 8.1 Introduction 233 8.2 STRs and Mini-STRs 235 8.3 Lineage Markers 237 8.4 Next Generation Sequencing 240 8.5 Rapid DNA 241 8.6 Conclusion 243 References 243 9 The Victim Information Center and Data Collection: Its Evolving Role in DVI 249Jason H Byrd 9.1 Introduction 249 9.1.1 History of the Family Assistance Center 250 9.2 Overall Function of the Victim Information Center 251 9.2.1 Incident Operations 252 9.2.2 Meeting the Needs of Families and Survivors 253 9.2.3 Briefings and Communication 254 9.3 Components of the Victim Information Center 255 9.3.1 Temporary Reception Center 255 9.3.2 Call Centers 255 9.3.2.1 Missing Persons Call Center 256 9.3.2.2 Air Carrier Call Center 256 9.4 Accounting for the Victims 257 9.4.1 Victim Information Program 257 9.5 Considerations for the Victim Information Center 259 9.5.1 Equipment and Personnel 259 9.5.2 Function and Location 261 9.5.3 Closing the Victim Information Center 262 9.6 Available Resources 263 References 264 10 Ethical and Legal Considerations 265Victor W Weedn 10.1 Introduction 265 10.2 State Authority for Fatality Management 265 10.3 Federal Medicolegal Death Investigations 267 10.3.1 Assassination of the President or Other Federal Officials 267 10.4 Legislatively Mandated Scientific Identification 267 10.5 Missing Persons Acts and Presumptive Deaths 268 10.6 Rights of the Dead 269 10.7 Rights of Others in the Dead 269 10.8 Constitutional Considerations in Responding to Disasters 270 10.9 Emergency Powers 271 10.10 Stafford Act 271 10.11 Federal Executive Administration 274 10.12 State and Local Executive Administration 276 10.13 Military Assistance 276 10.14 Transportation Incidents 278 10.15 Terrorist Incidents 279 10.16 Infectious Epidemics 279 10.17 National Emergency Family Registry and Locator System/National Call Center 280 10.18 International Legal Considerations in DVI 281 10.18.1 The US Department of State 281 10.18.2 Nation-specific Laws 281 10.18.3 Obligation to Identify Victims 282 10.18.4 International Disaster Response Law 283 10.18.5 International Treaties 284 10.18.6 International Humanitarian Law 286 10.18.7 International Human Rights Law 287 10.18.8 Missing and Disappeared Treaties 288 10.18.9 International Resources 288 10.18.10 Aviation and Maritime Deaths 290 10.18.11 Presumed Deaths 291 10.18.12 Customs 292 10.18.13 Telecommunications 292 10.18.14 International Framework for Risk Reduction 292 10.19 Ethical Considerations in DVI 293 10.19.1 Community Resilience 295 10.19.2 Equal Treatment 296 10.19.3 Respectful Treatment of the Remains 296 10.19.4 Respect for the Beliefs of the Deceased 296 10.19.5 Respect for Loved Ones 296 10.19.6 Respectful Communications 297 10.19.7 Haitian Example [184–186] 297 10.20 Conclusion 298 References 299 11 DVI in the Changing Twenty-first Century 313Cynthia S Gavin 11.1 Introduction 313 11.2 Trend Analysis 314 11.2.1 Megatrend #1: Population Shift and Megacity Growth 315 11.2.2 Megatrend #2: Change in Disaster Types that Result in MFIs 315 11.2.3 Megatrend #3: Massive Technological Advancement 318 11.2.4 Megatrend #4: Social Media and Social Expectations 320 11.2.5 Megatrend #5: The Specialization of Ethics 321 11.2.6 Megatrend #6: A New Dynamic Disaster Management System 322 11.2.7 Megatrend #7: A New DVI Model 323 11.2.8 Megatrend #8: Healthcare and the National and International Privatization of Medicine 325 11.3 Forcefield Analysis 326 11.3.1 Drivers of Change: Regulation and Legal Factors 326 11.3.2 Drivers and Constrainers of Change: Politics 328 11.3.3 Constrainers of Change 332 11.3.4 A Neutral Context to Gain Insight regarding Driving and Constraining Forces 337 11.4 DVI Futures in the Twenty-first Century 339 11.4.1 The Quantum Forensics World 340 11.4.2 The Modern Crowners World 341 11.4.3 The Launch-Resistant Forensics World 342 11.4.4 The Hey Buddy Innovator World 342 11.5 Future DVI Strategy Performance 343 11.5.1 DVI Strategies 343 11.5.2 Stress-Testing Strategies Against DVI Futures 344 11.6 SWOT Analysis 350 11.6.1 Strengths 350 11.6.2 Weaknesses 351 11.6.3 Opportunities 351 11.6.4 Threats 352 11.7 Actionable Recommendations 352 11.7.1 Refresh the ME/C Mission Statement 352 11.7.2 Create an Enduring DVI Vision 354 11.7.3 Envision a Future Smart Independent Regional Forensic Science System and Move Toward Implementing This Model 356 11.7.4 Develop Alternate DVI Standards 358 11.8 Closing Thoughts 360 References 362 Index 371
£104.36
John Wiley & Sons Inc Burnt Human Remains
Book SynopsisBURNT HUMAN REMAINS An all-encompassing reference and guide designed for professionals involved in the forensic analysis of burnt remains Burnt Human Remains: Recovery, Analysis and Interpretation presents an in-depth multidisciplinary approach to the detection, recovery, analysis, and identification of thermally altered remains. Bridging the gap between research and practice, this invaluable one-stop reference provides detailed coverage of analytical techniques in forensic medicine and pathology, forensic anthropology, forensic odontology, and forensic chemistry and forensic biology. Contributions from a panel of expert authors review the newest findings in forensics research and discuss their applicability to forensic case work. Opening with a historical overview of the discipline, the book covers the search and recovery aspects of burnt human remains, medico-legal investigations, determination of the post mortem interval of burnt remains, structuTable of ContentsAbout the Editors xiii List of Contributors xv Preface xxvii Series Preface xxix 1 History of the Study of Burnt Remains 1Douglas H. Ubelaker and Austin A. Shamlou 1.1 Early Developments Prior to 1980 1 1.2 Post-1980 Advanced Experimentation and Casework 3 1.3 The 1990s: New Methods and Case Applications 4 1.4 Summary and Conclusions 6 References 7 Part 1 Search and Recovery of Burnt Human Remains from the Fire Scene 2 Fire Environments and Characteristic Burn Patterns of Human Remains from Four Common Types of Fatal Fire Scenes 13Elayne Pope 2.1 Introduction 13 2.2 Experimental Research of Fire and Human Bodies 14 2.3 How the Human Body Burns 14 2.4 Variables of Fire Environments 17 2.5 Structure Fires 18 2.6 Burning Directly on the Floor 19 2.7 The Body on Furnishings: Couches and Chairs 19 2.8 The Body on Furnishings: Bed 21 2.9 Loss of the Floor 22 2.10 Collapse into a Lower Level 23 2.11 Vehicle Fires 24 2.12 Driver and Passenger Space 25 2.13 Rear Passenger Space with Bench Seats 26 2.14 Trunk Environment 26 2.15 Confined Space Fires 28 2.16 Outdoor Space Fires 29 2.17 Ignitable Liquids on Bodies 29 2.18 Burning Outdoor Debris Piles 30 2.19 Post-Fire Fragmentation of Burnt Bones 31 2.20 Suppression 32 2.21 Recovery and Transport from Fatal Fire Scenes 33 2.22 Conclusions 35 References 35 3 Recovery and Interpretation of Human Remains from Fatal Fire Scenes 37Alexandra R. Klales; Allison Nesbitt; Dennis C. Dirkmaat and Luis L. Cabo 3.1 Introduction 37 3.2 Summary of Fires in the USA 39 3.3 Statement of the Problem 39 3.4 Current Fatal Fire Victim Recovery Protocols 42 3.5 NIJ Protocols 43 3.6 Special Circumstances 51 3.7 Conclusions 55 References 55 4 Considerations to Maximize Recovery of Post-mortem Dental Information to Facilitate Identification of Severely Incinerated Human Remains 59John Berketa and Denice Higgins 4.1 Introduction 59 4.2 Identification 59 4.3 Documentation 60 4.4 Preparation 61 4.5 Prepacked Scene Equipment 61 4.6 Scene Arrival 63 4.7 Safety Issues 63 4.8 Overall Scene Evaluation 65 4.9 Considerations Regarding DNA Evidence 66 4.10 Considerations Regarding Dental Evidence 67 4.11 Moving the Victim 69 4.12 Conclusions 71 References 71 Part 2 Examination and Identification of Burnt Human Remains 5 Methods for Analyzing Burnt Human Remains 75Amanda N. Williams 5.1 Anthropological Methods for Classifying Burnt Remains 76 5.2 Medicolegal Classification Methods 78 5.3 Need for New Model within the Forensic Sciences 79 5.4 A New Classification System 80 5.5 Best Practices in Applying this New Model 83 5.6 Case Study #1 83 5.7 Case Study #2 86 5.8 Case Study #3 88 5.9 Case Study #4 90 5.10 Case Study #5 92 5.11 Broader Implications 95 5.12 Conclusions 95 Acknowledgments 96 References 96 6 Burnt Human Remains and Forensic Medicine 99Sarah Ellingham; Joe Adserias-Garriga and Peter Ellis 6.1 Fire Death Statistics 99 6.2 Statistics of Manner of Fire-Related Deaths 100 6.2.1 Prevalence of Self-Immolation 100 6.2.2 Prevalence of Criminal Immolation 101 6.3 Fire Damage to the Body 102 6.4 Classification of the Degree of Fire Damage 103 6.5 Medicolegal Determination of Cause of Death 105 6.6 Medicolegal Determination of Manner of Death 106 6.7 The Use of Post-Mortem Imaging for the Analysis of Burn Victims 108 6.8 Conclusion 110 Acknowledgments 110 References 110 7 Skeletal Alteration of Burnt Remains through Fire Exposure 113Joe Adserias-Garriga 7.1 Assessment of the Severity of the Thermal Damage in the Forensic Context 114 7.2 Soft Tissue Alterations by Fire Exposure 115 7.3 Bone Alteration by Fire Exposure 116 7.4 Teeth Alteration by Fire Exposure 120 7.5 Signature Changes in Skeletal Elements after Cremation 122 7.6 Conclusions 129 References 130 8 Challenges of Biological Profile Estimation from Burnt Remains 133Tim J.U. Thompson 8.1 Why Does Burning Affect Methods of Identification? 134 8.2 How Does the Context of Burning Impede the Creation of Biological Profiles? 135 8.3 Challenges of Biological Profile Estimation of Burnt Remains 137 8.3.1 Morphological Methods 137 8.3.2 Metric Methods 139 8.3.3 Other Approaches to Biological Profile Estimation 140 8.4 Conclusions 142 References 142 9 Victim Identification: The Role of Incinerated Dental Materials 147Peter J. Bush; Mary A. Bush and Raymond Miller 9.1 Introduction 147 9.2 Microstructural Changes in Teeth after Incineration 148 9.3 Structural Changes Due to Restorative Procedures 149 9.4 Case Reports 151 9.4.1 Case Report 1: Airline Crash 151 9.4.2 Case Report 2: Double Homicide 161 9.5 Conclusions 165 References 166 10 Techniques for the Differentiation of Blunt Force Sharp Force and Gunshot Traumas from Heat Fractures in Burnt Remains 167Hanna Friedlander; Megan Moore and Pamela Mayne Correia 10.1 Introduction 167 10.2 Bone Fracture Biomechanics: Fresh Bone 168 10.3 Bone Fracture Biomechanics: Stages of Thermal Damage 170 10.4 Heat Fractures 171 10.5 Blunt Force Trauma in Burnt Remains 172 10.6 Sharp Force Trauma in Burnt Remains 175 10.7 Gunshot Trauma in Burnt Remains 177 10.8 Case Study: 3D Modelling of Traumatic and Heat Fractures in Cranial and Irregular Bone 179 10.9 Discussion 182 10.10 Conclusions 184 Acknowledgments 185 Permissions 185 References 185 Part 3 Analytical Approaches to the Analysis of Burnt Bone 11 Biochemical Alterations of Bone Subjected to Fire 193Sarah Ellingham and Sara C. Zapico 11.1 The Biological and Chemical Makeup of Fresh Bone 193 11.1.1 Introduction 193 11.2 Bone Transformation When Subjected to Heat 195 11.3 Analytical Approaches to Observing Bone Transformation 196 11.3.1 Colorimetry 196 11.3.2 SEM-EDX 196 11.3.3 Fourier Transform Infrared-Spectroscopy 198 11.3.4 Raman Spectroscopy 200 11.3.5 X-Ray Diffraction 201 11.3.6 Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC) 202 11.3.7 Amino Acid Racemization 202 11.4 DNA 204 11.5 Changes to the Bone at Different Temperatures 205 11.5.1 100°C Exposure 205 11.5.2 200°C Exposure 206 11.5.3 300°C Exposure 206 11.5.4 400°C Exposure 207 11.5.5 500°C Exposure 207 11.5.6 600°C Exposure 207 11.5.7 700°C Exposure 207 11.5.8 800°C Exposure 208 11.5.9 900°C Exposure 208 11.5.10 1000°C Exposure 208 11.6 Conclusion 208 Acknowledgment 209 References 209 12 DNA Profiling from Burnt Remains 213Sara C. Zapico and Rebecca Stone-Gordon 12.1 Introduction 213 12.2 Research Studies on Burnt Remains 214 12.3 Forensic Cases 218 12.4 Alternative Approaches and New Technologies 221 12.4.1 Assessment of DNA Damage 221 12.4.2 Alternatives for DNA Extraction 222 12.4.3 New Technologies 223 12.5 Conclusions 225 References 226 13 Applying Colorimetry to the Study of Low Temperature Thermal Changes in Bone 229Christopher W. Schmidt and Alexandria McDaniel 13.1 Introduction 229 13.2 Colorimetry 230 13.3 Challenges of Colorimetry 232 13.4 Case Study 233 13.5 Conclusion 236 References 236 14 The Use of Histology to Distinguish Animal from Human Burnt Bone with Reference to Some Limitations 241Pamela Mayne Correia; Kalyna Horocholyn and Kassandra Pointer 14.1 Introduction 241 14.2 Bone Tissue 242 14.2.1 Primary Bone Tissue 243 14.2.2 Secondary Bone 252 14.3 Vertebrate Histology 254 14.4 Burnt Bone Histology 256 14.5 Case Study for Comparison of Histology of Cremated Bone 259 14.5.1 Qualitative and Quantitative Analysis for Case Study 259 14.6 Discussion 264 14.7 Conclusion 266 References 267 15 Isotope Analysis from Cremated Remains 273Christophe Snoeck 15.1 Introduction 273 15.2 Infrared Analyses 274 15.3 Radiocarbon Dating 276 15.4 Isotope Analyses 277 15.4.1 Carbon and Oxygen Isotope Ratios 277 15.4.2 Strontium Isotope Ratios and Concentrations 281 15.5 Archaeological Case Studies 282 15.5.1 Stonehenge 282 15.5.2 Meuse Basin Belgium and the Netherlands 283 15.6 Conclusions 285 Acknowledgments 285 References 285 16 The Application of Imaging to Heat-Induced Bone 291Rachael M. Carew and David Errickson 16.1 Introduction 291 16.2 Technological Progression 292 16.3 The Current Technology 294 16.3.1 Two-Dimensional Imaging 294 16.3.2 Three-Dimensional Imaging 295 16.4 The Application of Imaging to Heat-Induced and Burnt Bodies 299 16.4.1 Locating and Identifying Burnt Bone 299 16.4.2 Visual Capture and Documentation for Recording and Archiving 300 16.4.3 Quantifying and Analyzing Burnt Remains 301 16.4.4 Reconstruction 302 16.4.5 Ethical and Legal Considerations within the Forensic Context 305 16.5 Discussion and Conclusion 306 References 308 17 The First Reference Collection for the Research of Burnt Human Skeletal Remains Stemming from the 21st Century Identified Skeletal Collection (Portugal) 313David Gonçalves; Calil Makhoul; Maria Teresa Ferreira and Eugénia Cunha 17.1 Introduction 313 17.1.1 The Challenge Posed by Burnt Skeletal Remains 313 17.1.2 Changing the Paradigm 315 17.1.3 The 21st Century Identified Skeletal Collection 320 17.1.4 Preparing the Skeletons 321 17.1.5 Composition of the Collection 323 17.2 Research Potential 324 17.3 Final Comments 327 Acknowledgments 328 References 328 Part 4 Case Studies 18 Analysis of Burnt Human Remains: Statistical Perspectives from Casework in Forensic Anthropology 337Douglas H. Ubelaker; Cassandra M. DeGaglia and Haley Khosrowshahi 18.1 Introduction 337 18.2 Materials and Methods 337 18.3 Results 339 18.4 Discussion 342 18.5 Conclusions 344 Literature Cited 344 19 The Challenge of Burnt Remains from the Brazilian “Microwave Oven” 345Melina Calmon Silva; Eugénia Cunha and Yara Vieira Lemos 19.1 Introduction 345 19.2 Brazilian Homicide Rates 346 19.3 The Relationship between Homicide and Drugs 347 19.4 The “Microwave Oven” Modality of Death / Disposability of Human Remains 348 19.4 Phases of Rubber Tire Combustion 350 19.5 The Challenges of Investigating “Microwave Oven” Deaths 351 19.6 The Role of Forensic Anthropology 353 19.6.1 Case Study 1 354 19.6.2 Case Study 2 359 19.7 Conclusion 365 Conflicts of Interest 366 Ethical Approval 366 Acknowledgments 366 References 367 20 Recovery and Identification of Fatal Fire Victims from the 2018 Northern California Camp Fire Disaster 371Colleen Milligan; Alison Galloway; Ashley Kendell; Lauren Zephro; P. Willey and Eric Bartelink 20.1 Overview of the Camp Fire 371 20.2 Wildfire Burn Environments and Condition of Remains 374 20.3 Field to Morgue: What’s Important for Identification Efforts? 375 20.4 Morgue Identification 379 20.5 Conclusions 381 References 381 21 Recovery and Identification of Burnt Remains in a Military Theatre of Operations: The Warrior Six 383Julie Roberts 21.1 Introduction 383 21.1.1 Improvised Explosive Devices and Blast Injuries 384 21.1.2 The Effects of Heat on Bone 384 21.2 Background to the Case 385 21.3 Assessment of the Vehicle and Recovered Remains 387 21.4 Excavation Strategy and Methodology 390 21.5 Examination of the Remains in the Temporary Mortuary 394 21.6 Examinations in the Role 3 Hospital 398 21.6.1 Soldier A 398 21.6.2 Soldier B 398 21.6.3 Soldier C 399 21.6.4 Soldier D 399 21.6.5 Soldier E 400 21.6.6 Soldier F 400 21.7 Post-mortem Examinations and Positive Identification in the UK 401 21.8 Conclusions 403 Acknowledgments 403 References 403 22 Volcanoes Bones and Heat: The Case of the AD 79 Victims of Vesuvius 407Pier paolo Petrone 22.1 Introduction 407 22.2 The AD 79 Eruption of Vesuvius 408 22.3 The Date of the Eruption 410 22.4 Historical and Archaeological Context of the Discovery 411 22.5 Bioarchaeological and Taphonomic Study 413 22.6 The Causes of Death 418 22.7 The Most Recent Studies 420 22.8 An Exceptional Discovery 427 22.9 Conclusions 430 References 431 Index 437
£130.50
John Wiley & Sons Inc Health Promotion Programs
Book SynopsisTable of ContentsContentsIntroduction Part One: Health Promotion Program FoundationsChapter 1- What are Health Promotion Programs?Chapter 2- Health Promotion, Equity, and Social JusticeChapter 3- Theory in Health Promotion Programs Part Two: Planning Health Promotion Programs Chapter 4- Assessing the Health Needs of a Defined Population Chapter 5- Making Decisions to Create and Support a Program Part Three: Implementing Health Promotion Programs Chapter 6- Implementation Tools, Program Staff, and Budgets Chapter 7- Advocacy Chapter 8- Communicating Health Information Effectively Chapter 9- Where Money Meets Mission: Developing, Increasing and Sustaining Program FundingPart Four: Evaluating and Sustaining Health PromotionChapter 10- Evaluating and Improving Health Promotion Programs Chapter 11- Using Big Data for Action and Impact Chapter 12- Sustaining Health Promotion Programs Part Five: Health Promotion Programs in Diverse Settings Chapter 13- School Health Education: Promoting Health and Academic SuccessChapter 14- Promoting Health in Colleges and Universities Chapter 15- Patient-Centered Health Promotion Programs in HealthcareChapter 16- Health Promotion Programs in Workplace Settings Chapter 17- Promoting Community Health: Local Health Departments and Community Health Organizations Index
£76.46
John Wiley & Sons Inc Disaster Response and Recovery
Book SynopsisTable of ContentsAbout the Author xvii Foreword xix Preface xxi Acknowledgments xxv About the Companion Website xxvi 1 Knowing What to Expect: Hazards, Vulnerability, and Disasters 1 2 Understanding the Actors: Roles and Responsibilities of Relevant Stakeholders 53 3 Anticipating Attitudes and Behavior in Disasters: Myths, Exaggerations, and Realities 93 4 Applying Alternative Management Approaches: Disaster Response and Recovery Theory 123 5 Implementing Initial Response Measures: Hazard Detection, Warning, Evacuation and Sheltering 149 6 Caring For the Injured, Dead, and Distraught: Overcoming Physical and Emotional Impacts 191 7 Managing Public Information, Donations, and Volunteers: Expected Difficulties and Benefits 237 8 Moving Beyond Immediate Needs: Damage Assessment, Disaster Declarations, and Debris Removal 277 9 Promoting Recovery and Mitigation: Disaster Assistance, Rebuilding, and Vulnerability Reduction 317 10 Overcoming Typical Challenges: Vital Considerations for Response and Recovery 357 11 Harnessing Technology and Organization: Tools and Structures for Effective Operations 407 12 Foreseeing the Future: Prior Lessons, Unaddressed Risks, and Rising Vulnerability 455 13 Enhancing Disaster Resilience: Preparedness, Improvisation, Spontaneous Planning, Leadership, and Professionalism 517 Index 559
£70.25
John Wiley & Sons Inc Impacts of the Covid19 Pandemic
Book SynopsisIMPACTS OF THE COVID-19 PANDEMIC Enables Readers to Understand the Impact of International Legislative and Policy Responses to the COVID-19 Pandemic The wide array of legal and policy responses to the COVID-19 pandemic have significant implications regarding the functioning of countries and their respective societies. This book addresses the impact of international legislative and policy responses to the COVID-19 pandemic in a range of countries. To aid the reader in understanding country-specific developments, each chapter focuses on a specific country and addresses the legal frameworks and policy approaches used to support measures to prevent transmission and otherwise reduce the impact of the virus on society and the economy. Sample topics discussed in the work include: The effect certain policies may have on civil liberties, such as due process, and the right to privacy in specific countries The provision of public goods in the face of the paTable of ContentsNotes on Contributors xiii Foreword xv Preface xix Section 1 Countries with a Focus on the Rule of Law and Legal Protections of Civil Liberties 1 1 The Netherlands: Dutch COVID-19 Policy Viewed from a Fundamental Rights Perspective 3Adriaan J. Wierenga and Jorrit Westerhof 1.1 Introduction 3 1.2 Disaster Management in the Netherlands 4 1.2.1 Functional and General Chain of Command 4 1.2.2 The COVID-19 Crisis 5 1.3 The Public Health Act 2008 (Functional Chain of Command) 5 1.3.1 National Crisis Structure 6 1.3.2 Measures 7 1.4 Municipal Emergency Powers (General Chain of Command) 8 1.4.1 Areas of Tension 8 1.4.2 Debatable Limitations of Fundamental Rights 9 1.4.3 Democratic Control and Administrative Supervision 10 1.5 Interim COVID-19 Measures Act (Addition to the Functional Chain of Command) 11 1.5.1 Improvements and Shortcomings 12 1.5.2 Legitimate Limitation of Fundamental Rights 12 1.5.3 Stricter Democratic Control 13 1.6 National Emergency Law 14 1.6.1 Separate Implementation 15 1.6.2 Criticism 16 1.6.3 The Curfew Case 17 1.7 Conclusion 18 References 19 2 Emergencies, Executive Power, and Ireland’s Response to the Covid-19 Pandemic 23Alan Greene 2.1 Introduction 23 2.2 Ireland’s Constitutional Emergency Framework 24 2.2.1 International Human Rights Law 26 2.3 Ireland’s Pandemic Response and Constitutional Constraints 27 2.3.1 Pandemic Rent Controls and Constitutional Constraints 28 2.3.2 Executive Supremacy and the COVID-19 Pandemic 29 2.4 Ireland’s Pandemic Response and Human Rights 31 2.4.1 The Pandemic and the Right to Liberty 31 2.4.1.1 Mandatory Hotel Quarantine 32 2.4.2 Quarantine and Detention at Home 34 2.5 Data Protection, Surveillance, and Discrimination Issues 36 2.5.1 Vaccination and Vaccine Passports 37 2.6 COVID-19 and the Rule of Law in Ireland 38 2.7 Conclusions 39 3 COVID-19: Legal Lessons Learned in Switzerland 41Felix Uhlmann 3.1 Introduction 41 3.2 Legal Framework 41 3.2.1 Legal Framework before COVID-19 (Swiss Epidemics Act) 41 3.2.1.1 Scope and Goals 41 3.2.1.2 Normal, Particular, and Extraordinary Situations 42 3.2.1.3 Measures 44 3.2.2 Legal Framework Under COVID-19 45 3.2.2.1 First and SecondWave 45 3.2.2.2 Financial Aid 47 3.2.2.3 The Federal Council and Other Actors 48 3.3 Contact Tracing App 48 3.4 Fundamental Rights (Civil Liberties) 50 3.4.1 Restrictions on Daily Life 50 3.4.2 Vaccinations 52 3.5 Assessment 53 References 54 4 Not Dead Yet: Protest, Process, and Germany’s Constitutional Democracy Amid the Coronavirus Response 59Carolyn Halladay 4.1 The FirstWave: So Far, So Good 60 4.2 Proportionality and its Discontents 65 4.3 Summer in the City 67 4.4 Is it an Emergency Yet? 71 4.5 Second Guessing the SecondWave 75 4.6 Happily Ever After? 77 5 The United Kingdom Legislative Response to Coronavirus: Shotgun or Machine Gun 79Ronan Cormacain and Duncan Fairgrieve 5.1 Introduction 79 5.2 Reliance Upon Law 79 5.3 Nature of the Legal Framework 80 5.3.1 Machine Gun Legislative Response 80 5.3.2 Devolution and the Legislative Response 80 5.3.3 Overview of the Legislative Framework 81 5.3.4 Pre-existing Laws or New Laws 84 5.3.5 Use of Emergency/Urgency Powers and Procedures or Use of Regular Powers and Procedures 84 5.3.6 Sunset Clauses/Expiry Dates 86 5.4 Substance of the Legal Response 86 5.4.1 Restrictions on Individual Liberties 86 5.4.2 Travel Restrictions 87 5.4.3 Vaccination Policy 87 5.4.4 Track and Trace 90 5.4.5 Support Measures – Furlough Payments, no Evictions 90 5.5 Problems/Analysis of the Legal Response 91 5.5.1 Reliance upon Emergency Procedures and Processes to Make Law in a Rush 91 5.5.2 Lack of Effective Parliamentary Scrutiny 92 5.5.3 Conflation of Law with Guidance 93 5.5.4 Inaccessible and Unintelligible Legislation 94 5.5.5 Risk of Creep of Emergency Practices into Normal Lawmaking 95 5.5.6 Compliance with the Rules by Those in Power 96 5.6 Conclusion 96 Section 2 Countries making Extensive use of Emergency Laws and Securitization 99 6 The State of Exception and its Effects on Civil Liberties in Italy During the COVID-19 Crisis 101Anna Malandrino, Margherita Paola Poto, and Elena Demichelis 6.1 Introduction 101 6.2 Defining the Elements of States of Exception (SoE) 103 6.2.1 States of Exception in the General Context 103 6.2.2 Italy 103 6.3 States of Exception During the Pandemic: Declaration, Implementation, and Effects 108 6.3.1 Establishing and Implementing the States of Exception 108 6.3.2 The Potential Effects of States of Exception on Civil Liberties 109 6.4 States of Exception and Containment Measures during the COVID-19 Pandemic in Italy: Regulatory Aspects 110 6.5 States of Exception and Containment Measures During the COVID-19 Pandemic in Italy: Implementation 112 6.6 The Effects of States of Exception Measures on Civil Liberties 113 6.7 Conclusions 116 References 116 7 Praise the Alarm: Spain’s Coronavirus Approach 121Carolyn Halladay, Florina C. Matei, and Andres de Castro 7.1 Quien aprisa juzgó, despacio se arrepintió: The Early Days of COVID and the Spanish Response 123 7.2 Culpa no tiene, quien hace lo que debe: The FirstWave and the First Lockdown 125 7.3 Cada uno quiere justiciar, mas no por su casa: The SecondWave and the Second Lockdown 130 7.4 Con necesidad, no hay ley? States of Emergency in Spain and Beyond 133 7.5 Hasta que pruebes, no absuelvas ni condenes: COVID and the Law Amid Spanish Tensions 137 7.6 El fin veremos; hasta entonces no hablemos: Conclusion 139 8 Pandemic Pangs and Fangs: Romania’s Public Safety and Civil Liberties in the COVID-19 Era 141Florina C. Matei 8.1 Legal Framework and Policy Approaches Vis-À-Vis Quarantine, Isolation, and Other Social Distancing Measures 141 8.2 Quarantine, Isolation, and Other Social Distancing Measures During the Covid-19 Pandemic 144 8.2.1 From a State of Emergency amidst a Political Crisis… 144 8.2.2 …To a State of Alert: Anachronistic Legislation Meets Ebbing and Flowing Restrictions 150 8.2.2.1 Vaccination Campaign: Needles for Fangs 153 8.2.3 Transparency During the Pandemic: Between Thought Police, Strategic “Mis” Communications, and Conspiracy Theories 154 8.2.3.1 Civil Society: A Tamed yet Clamorous Cerberus? 157 8.2.4 A “Plagued” Executive–Legislative–Judiciary Trifecta 159 8.3 Conclusion: Civil Liberties and Freedoms 161 9 Policymaking and Liberty Restrictions in the Covid-19 Crisis, the Case of France 165Angelique Palle, Lisa Carayon, François Delerue, Florian Opillard, and Christelle Chidiac Disclaimer 165 9.1 Introduction 165 9.2 Policymaking and Liberty Restrictions in France During Covid-19 Crisis, Research Questions and Methodology 166 9.3 Regulation and Policymaking in France During Covid-19, Context and Background 167 9.4 “State of Emergency Related to the Sanitary Situation/Etat d’Urgence Sanitaire”: The Recourse to an Exceptional Legal Framework 169 9.5 The Involvement of the Armed Forces in France in the Covid-19 Crisis Management, Between Political Display and Response to the Crisis 170 9.6 Perception by the French Population of the Missions Performed by the Armed Forces and of the Nature of the Covid-19 Crisis 172 9.7 Analyzing Local and Regional Measures of Civil Liberties’s Restrictions in the Context of the “State of Emergency Related to the Sanitary Situation” (état d’urgence sanitaire), the Case of the Freedom of Movement throughout the First to the Second Confinement 173 9.8 Legitimizing Civil Liberties Restrictions and Shaping the Governance of Policymaking, Comparison of the Two Cities of Rennes and Nice 175 9.9 Conclusion 179 References 179 Section 3 Countries Focused on Population Monitoring and Restrictions 181 10 Policy Measures, Information Technology, and People’s Collective Behavior in Taiwan’s COVID-19 Response 183Cheryl Lin, Pikuei Tu, Wendy E. Braund, Jewel Mullen, and Georges C. Benjamin 10.1 Introduction 183 10.2 A Snapshot of Taiwan 184 10.2.1 The Legal Framework Pertaining to Pandemic Response 184 10.2.1.1 Epidemic Control and Public Health Emergency 184 10.2.1.2 Personal Information 186 10.3 The Ominous Beginning of the Pandemic 186 10.3.1 Swift Responses Early On 187 10.4 Blocking Infection Importation and Local Transmission 188 10.4.1 Tightened Border Control 188 10.4.2 Rigorous Contact Tracing 189 10.4.2.1 Augmentation with Information Technology (IT) 189 10.4.3 Enforcing Quarantine – Operations and Mechanism 190 10.4.3.1 Provisions, Compensation, and Penalties During Quarantine 190 10.5 Active Participatory Role of the Public – Awareness and Preventive Behavior 192 10.5.1 Common Use of Masks and Response to Shortage 192 10.5.2 Promoting and Self-Adhering to Social Distancing 192 10.6 Healthcare System and Capacity 193 10.6.1 National Health Insurance (NHI) and Data Integration 193 10.6.2 Infectious Disease Control Medical Network 194 10.6.3 Assuring Care and Support for the Providers 195 10.7 The Heights of Cases, Anxiety, and Dilemmas 195 10.7.1 The Surge of Spring/Summer 2021 196 10.7.2 Amended Policies and Reflections of the Surge 197 10.8 Vaccine Supply, Hesitancy, and Distribution 198 10.8.1 Slow Delivery and Shortage of Supply 198 10.8.2 Vaccine Hesitancy and Demand 199 10.8.3 Vaccine Prioritization and Administration 200 10.9 Reflections and Conclusions 200 References 201 11 The Legislative and Political Responses of Viet Nam to the Covid-19 Pandemic: The Balancing of Public Health and Collective Civil Liberties 209Nguyen T. Trung and Nguyen Q. Duong Disclaimer 209 11.1 Introduction 209 11.2 Background: The FourWaves of Covid-19 in Viet Nam 211 11.2.1 The FirstWave (23 January–19 April 2020) 211 11.2.2 The SecondWave (25 July–2 September 2020) 212 11.2.3 The ThirdWave (28 January–13 March 2021) 213 11.2.4 The FourthWave (27 April–15 July 2021) 214 11.3 The Legislative Framework in Combating Infectious Disease 215 11.3.1 Legislative and Administrative Documents in Vietnam 215 11.3.2 The Constitution 215 11.3.3 The 2007 Law on Prevention and Control of Infectious Diseases 216 11.3.3.1 Prevention Measures 217 11.3.3.2 Combating Measures 217 11.3.3.3 Prohibited Activities and Fines for Failures to Implement Prevention and Combating Measures 218 11.3.4 The Criminal Code 219 11.3.5 Three Directives of the Prime Minister 220 11.4 The Policy Responses of the Vietnamese Government During the Pandemic 221 11.4.1 The Contact Tracing System 222 11.4.2 Quarantine Regulation 223 11.4.3 Social Distancing Measures 224 11.5 The Paradigm Shift in the Legal and Political Responses and the Balancing of Public Health and Civil Liberties 224 11.5.1 The Paradigm Shift in the Legal and Political Responses 225 11.5.2 The Balancing of Public Health and Civil Liberties 226 11.6 Conclusion 228 References 230 12 Singapore United 235Jacinta I-Pei Chen, Sharon H.X. Tan, Peak Sen Chua, Jeremy Lim, and Jason Chin-Huat Yap 12.1 Governing Philosophy and Laws 235 12.2 Early Response to Circuit Breaker (February–May 2020) 237 12.2.1 Enforcement Approach 242 12.2.2 Financial and Other Supportive Resources 243 12.2.3 Religion, Marriage, and Family Life 244 12.2.4 Communications 245 12.3 Relaxation of Measures (June 2020–April 2021) 246 12.3.1 Prioritizing Sectors 251 12.3.2 Strengthening Outbreak Control Capabilities 251 12.3.3 General Elections 2020 253 12.4 Heightened Alert (May 2021–June 2021) 254 12.5 Leveraging Technology 261 12.5.1 Data Privacy, Security, and Governance 263 12.5.2 What Next? 264 12.6 MigrantWorker Dormitories 264 12.6.1 The Regulatory Regime 265 12.6.2 The Dormitory Outbreaks 265 12.6.3 Reflections 266 12.7 Discussion 271 12.8 Conclusion 272 Acknowledgements 273 References 273 Section 4 Countries Focused on Fostering Popular Trust in Government, Emphasizing Social Welfare, and Limiting Sanctions and Restrictions 301 13 Sweden and Covid-19: A (Mainly) Recommendary Approach 303Iain Cameron and Anna Jonsson Cornell 13.1 Introduction 303 13.2 Setting the Stage – The Initial Swedish Response to the Pandemic 303 13.3 The Constitutional Context 305 13.4 The Legislative Procedure, Delegation of Powers, and Rights Protection 308 13.5 The Public Health Agency and the Act on Protection Against Contagious Diseases 309 13.6 Legal Measures Taken to Counter the Spread of Covid-19 311 13.7 Vaccination and Exit Strategies 312 13.8 Putting the Swedish Soft Power Strategy in Context 313 13.9 Evaluating the Swedish Measures from a Rule of Law Perspective 315 13.10 Concluding Remarks 319 14 Administrative Guidance in Coronavirus Special Measures Act in 2021 in Japan 323Yuichiro Tsuji 14.1 The 2020 CSMA 323 14.1.1 2021 CSMA and Administrative Guidance 323 14.1.2 How CSMA was Amended 325 14.1.3 How CSMA was Amended, and Why 326 14.1.4 Legalization of the Self-restraint Order 326 14.1.5 Sanctions, not Penal but Administrative 327 14.1.6 Revision of the Infectious Diseases Act 328 14.2 Administrative Guidance and COVID-19 in 2021 329 14.2.1 Traditional Theory in Japanese Administrative Law 330 14.2.2 Legal Control of Administrative Guidance 330 14.2.3 Art. 33 of APA When a Citizen does not Follow Administrative Guidance 331 14.2.4 Public Announcement 332 14.2.5 Public Announcement in TMG 332 14.2.6 Merits and Demerits of Administrative Guidance 333 14.2.7 How to Impose Administrative Fine Procedural Requirement 334 14.2.8 APA Ordinance and TMG 334 14.3 Conclusion 335 References 336 15 Canada’s Fight Against COVID-19: Constitutionalism, Laws, and the Global Pandemic 339Iffath U. Syed 15.1 Non-Pharmaceutical Intervention (NPI) Measures 340 15.2 COVID-19 Special Acts for Relief and Compensatory Measures 341 15.3 Long-Term Care Crisis 346 15.4 Research and Vaccine Development Initiatives 347 15.5 Other Policies and Governmental Actions to Dampen the Pandemic 347 15.6 New Year, But Pandemic Looms 350 15.7 Summary, Limitations, and Concluding Remarks 351 References 351 16 Coronavirus and the Social State: Austria in the Pandemic 359Donald Abenheim and Carolyn Halladay 16.1 The Impfpflicht 361 16.2 The Freedom Party’s Liberties 363 16.3 A Bundle of Measures 364 16.4 A Decade or More of Crises 367 16.5 The Sozialstaat Strikes Back 371 16.6 Protest, Rhetoric, and the Law 373 16.7 Conclusion: Community, Communicability, and the Constitution 376 Afterword 379 Index 381
£65.25
John Wiley & Sons Inc Herbal Drugs for the Management of Infectious
Book SynopsisHerbal Drug for the Management of Infectious Diseases The book is a comprehensive compilation of herbal drug applications for the treatment and management of infectious diseases and addresses issues related to development, challenges, and future prospects associated with the use of herbal medicine. The use of herbal medicines has evolved in various cultures around the world over many millennia. In many developing Asian and African countries, the use of herbal medicines, as supplied by traditional medicinal practitioners, has always been popular. In the last two to three decades, many people in developed countries have begun to turn to alternative or complementary therapies, including the use of herbal medicines, nutraceuticals, functional foods, and other supplements. This resurgence in interest in plant-derived medicines is partly due to the growing dissatisfaction with allopathic medicines, as well as the perception that plant-derived mediTable of ContentsPreface xvii 1 Essential Oils as Potent Antimicrobial Agents 1Rakesh K. Sindhu, Prabhjot Kaur, Parneet Kaur, Sumitra Singh and Simona Cavalu 1.1 Introduction 2 1.2 Essential Oils 3 1.3 Chemical Composition of Essential Oils 5 1.4 Mechanism of Action of Essential Oils as Antimicrobials 11 1.5 Factors Affecting Antimicrobial Activity of Essential Oil 13 1.6 Essential Oils as Combination Therapy 13 1.7 Evaluation of Antimicrobial Efficacy of Essential Oils 14 1.8 Conclusion and Future Perspectives 16 2 Herbal Antibiotics for Treating Drug-Resistant Bacteria 23Haixia Chen and Shuqin Li 2.1 Introduction 24 2.2 Resistance Mechanism of Strains 25 2.3 The Classification of Herbal Secondary Metabolites for Drug Resistance 28 2.4 Mechanism 41 2.5 Conclusion and Perspectives 44 3 Phytopharmaceuticals for the Management of Fungal Infections 55Kampanart Huanbutta and Tanikan Sangnim 3.1 Introduction 55 3.2 Nature of Fungi and Classification of Fungal Disease 56 3.3 Epidemiology of Fungal Infection 58 3.4 Limitations of Modern Medicines 60 3.5 Medicinal Plants With Antifungal Activities 61 3.6 Phytopharmaceuticals With Antifungal Activities 63 3.7 Activity and Mechanism of Action of Antifungal Drugs and Phytopharmaceuticals 68 3.8 Conclusion and Future Prospect of Phytopharmaceuticals for the Management of Fungal Infections 72 4 Herbal Bioactives for the Management of Influenza Viral Infection 85Shaveta Bhardwaj, Jobanpreet Kaur, Atinderpal Kaur, Satvinder Kaur, Anu Jindal and Inderbir Singh 4.1 Introduction 86 4.2 Various Herbal Bioactives With Anti-Influenza Property 87 4.3 Mechanism of an Anti-Influenza Effect 91 4.4 Conclusion 93 5 Herbal Bioactives for Treating Respiratory Infections 101Chandrakantsing V. Pardeshi, Sagar R. Pardeshi, Jitendra B. Naik, Atul A. Shirkhedkar and Sanjay J. Surana 5.1 Introduction 101 5.2 Overview of Respiratory Tract Infections 103 5.3 Herbal Bioactives for the Management of RTIs 108 5.4 Bioactives and Their Derivatives Against Novel Coronavirus Disease 112 5.5 Emerging Drug Delivery Strategies for Biomedicines in the Management of RTIs 113 5.6 Clinical Status: Opportunities and Challenges 120 5.7 Patent Perspectives 120 5.8 Future Perspectives 122 5.9 Conclusion 122 6 Herbal Bioactives for the Treatment of Gastrointestinal Tract Disorders 133Manish Kumar, Inderjeet Verma, Rakesh Kumar Sindhu and Rishabh Srivastava 6.1 Introduction 134 6.2 Classification of GIT Disorders 134 6.3 The Science of Herbal Medicine 135 6.4 Need of Herbal Medicine 143 6.5 Indirect Adverse Effects of Herbal Therapy 144 6.6 Herbal Bioactive-Based Formulation 144 6.7 Recent Patents for Herbal Drug Delivery Systems 148 6.8 Future Perspective 148 6.9 Conclusion 148 7 Herbal Drugs for the Treatment of Ocular Infections 157A. A. Shirkhedkar, Mukesh S. Patil, A. S. Patil and Inderbir Singh 7.1 Introduction 158 7.2 Eye Essential Anatomy and Physiology 159 7.3 Preparation and Method of Use 161 7.4 Modern Investigations and Findings 163 7.5 Patents Recently Issued on Herbal Formulations 170 7.6 Conclusion 171 8 Phytopharmaceuticals for Treating Sexually Transmitted Diseases 179Kenneth Chinedu Ugoeze 8.1 Introduction 180 8.2 Disease 180 8.3 Infectious Diseases 181 8.4 Types of Infectious Diseases 181 8.5 Treatment of Sexually Transmitted Diseases 190 8.6 Phytochemicals 194 8.7 Phytopharmaceuticals 195 8.8 Future View of Phytopharmaceuticals: The Need for Patenting 225 8.9 Summary 226 8.10 Conclusion 229 9 Herbal Bioactives for Treating Infectious Skin Diseases 263Darshan R. Telange, Saurabh B. Ganorkar and Atul A. Shirkhedkar 9.1 History of Treating Skin Diseases With Herbs 264 9.2 Herbal Bioactives for Treating Infectious Skin Diseases 9.3 Herbs of Choice for Skin Infections 271 9.4 Herbal Bioactive--Based Formulations for Skin Infections 280 9.5 Patent Perspective 282 9.6 Futuristic View 283 9.7 Conclusion 284 10 Plant-Based Vaccines: Challenges and Opportunities 291Navgeet Kaur, Anju Goyal and Rakesh K. Sindhu 10.1 Introduction 292 10.2 Production Process of Plant-Based Vaccines 293 10.3 Current Scenario of the Vaccines 297 10.4 Challenges 299 10.5 Conclusion and Future Prospects 300 11 Herbal Medicines for HIV Infection and AIDS 307Thongtham Suksawat and Pharkphoom Panichayupakaranant 11.1 Introduction 308 11.2 Pathophysiology of HIV Infections 309 11.3 Current Treatments for HIV/AIDS 310 11.4 Targeting for Novel Drug Therapy Against HIV/AIDS 311 11.5 Herbal Extract and Phytochemicals with Anti-HIV Effects 312 11.6 Patents of Herbal and Phytochemical Products for Anti--HIV-1 Infections 330 11.7 Conclusions 332 12 Anthelmintic Potential of Herbal Drugs 341Kalpana Nagpal, Pravin Pawar, Ritu Rathi, Nishant Gaur and Inderbir Singh 12.1 Introduction 342 12.2 Drugs Used as Anthelmintics 342 12.3 Active Principles Derived From Medicinal Plants as Anthelmintic Compounds 349 12.4 Conclusion 352 13 Herbal Drugs for the Management and Treatment of Herpes Simplex Infections 359Wiwit Suttithumsatid and Pharkphoom Panichayupakaranant 13.1 Introduction 360 13.2 Pathophysiology of HSV Infections 360 13.3 Current Treatments for HSV Infection 361 13.4 Targeting for Novel Drug Therapy Against Herpes Simplex Infection 363 13.5 Herbal Extracts and Phytochemicals With Anti-HSV Activity 363 13.6 Recommended Herbal Extracts Used for Herpes Simplex Infection and Futuristic View 381 13.7 Patents on Herbal Medicine for Anti-Herpes Simplex Infections 381 13.8 Conclusions 383 14 Herbs and Plants Used for the Management and Treatment of Hepatitis Infections 389Omonike O. Ogbole, Temitayo A. Ajayi and Oluwatoyin A. Odeku 14.1 Introduction 390 14.2 Hepatitis 391 14.3 Herbal Medicine and Control of Viral Infection 397 14.4 Major Classes of Medicinal Plants Having Activity Against Hepatitis Virus 398 14.5 The Common Classes of Bioactive Compounds with Anti-Hepatitis Virus Activities 406 15 Herbal Bioactives for Treating Urinary Tract Infections 427Kashish Wilson, Manish Kumar, Prerna Sharma, Harkiran Nehra and Inderjeet Verma 15.1 Introduction 428 15.2 Discussion on Medicinal Plants 431 15.3 Causes of UTI 431 15.4 Symptoms of a UTI 432 15.5 Management 432 15.6 Herbs Employed for Therapy of Urinary Tract Infection 433 15.7 Causative Agents in Infection of Urinary Tract 436 15.8 Mechanism of Herbs 438 15.9 Future Prospective 438 15.10 Conclusion 439 16 Herbs Used in Parasitic Infection--Malaria 443M.G. Kalaskar, B. Duraiswami, S.J. Surana and A.A. Shirkhedkar 16.1 Introduction 444 16.2 Parasitic Infections 445 16.3 Antiparasitic Medicinal Plants and Their Mode of Action 450 16.4 Antimalarial Herb 452 References 509 Index 519
£170.10
John Wiley & Sons Inc Research Ethics for Scientists
Book SynopsisTable of ContentsPreface xi Acknowledgments xii About the Companion Website xiii Chapter 1 Research Ethics: The Best Ethical Practices Produce the Best Science 1 Judge yourself 6 Morality vs. ethics 6 Onward and upward 8 Inauspicious beginnings 8 How science works 10 Nothing succeeds like success 13 Summary 14 Chapter 2 How Honest Is Science? 15 Judge yourself 16 Sanctionable research misconduct: fabrication, falsification, and plagiarism 16 “Scientists behaving badly” 17 Do scientists behave worse with experience? 20 Judge yourself 20 Crime and punishment 21 Judge yourself 25 Discussion questions 27 Summary 28 Chapter 3 Research Misconduct: Plagiarize and Perish 29 Ideas 31 Sentences 32 Phrases 32 A hoppy example 33 What is plagiarism, really? 34 Judge yourself 34 How many consecutive identical and uncited words constitute plagiarism? 35 Self- plagiarism and recycling 36 Judge yourself 37 Judge yourself 44 Tools to discover plagiarism 46 iThenticate 46 References cited 48 Self- plagiarism and ethics revisited 51 Judge yourself 51 Is plagiarism getting worse? 52 The [true] case study: the plagiarizing novelist who also plagiarized her confession to plagiarism and the author of the website “Plagiarism Today” 54 Summary 55 Chapter 4 Finding the Perfect Mentor 56 Caveat 57 Choosing a mentor 58 Judge yourself 62 Choosing a graduate project 69 Judge yourself 69 Mentors for assistant professors 69 How to train your mentor 75 Discussion questions 78 Discussion questions 80 Summary 81 Chapter 5 Becoming the Perfect Mentor 82 Grants and contracts are a prerequisite to productive science 84 Judge yourself 85 Publications are the fruit of research 86 On a personal level 87 Judge yourself 88 Common and predictable mistakes scientist make at key stages in their training and careers and how being a good mentor can make improvements 88 Discussion questions 104 Summary 105 Chapter 6 Research Misconduct: Fabricating Data and Falsification 106 Why cheat? 107 Judge yourself 110 The case of Jan Hendrik Schön, “Plastic Fantastic” 110 The case of Woo- Suk Hwang: dog cloner, data fabricator 111 The case of Diederik Stapel, psychological serial fabricator 113 Judge yourself 114 Detection of image and data misrepresentation 116 Judge yourself 120 Lessons learnt 121 Summary 121 Chapter 7 Research Misconduct: Falsification and Whistleblowing 122 Reporting and adjudicating research misconduct 123 A “can of worms” indeed: the case of Elizabeth “Betsy” Goodwin 125 Judge yourself 128 Judge yourself 129 Judge yourself 131 Judge yourself 137 Judge yourself 140 Cultivating a culture of openness, integrity, and accountability 140 Summary 141 Chapter 8 Publication Ethics of Authorship: Who Is an Author on a Scientific Paper and Why 142 The importance of the scientific publication 143 Predatory publishing 145 Judge yourself 146 Who should be listed as an author on a scientific paper? 146 Judge yourself 150 How to avoid authorship quandaries and disputes 151 Authorship for works other than research papers 153 The difference between authorship on scientific papers and inventorship on patents 154 Other thoughts on authorship and publications 155 Judge yourself 157 Summary 162 Chapter 9 Grant Proposals: Ethics and Success Intertwined 163 Why funding is crucial 164 Judge yourself 168 Path to success in funding 168 Fair play and collaboration 170 Judge yourself 171 Judge yourself 173 Recordkeeping and fiscal responsibility 173 Pushing the limits on proposals 174 Summary 179 Chapter 10 Peer Review and the Ethics of Privileged Information 180 The history of peer review 181 The nature of journals and the purpose of peer review 182 Open- access journals vs. subscription journals 182 Which papers to review? 188 Open reviews and discussion 189 Judge yourself 190 Grant proposals 190 Confidentiality and privileged information 191 Reviewers 192 Judge yourself 192 Final thoughts 193 Summary 195 Chapter 11 Data and Data Management: The Ethics of Data 196 Stewardship of data 197 Judge yourself 199 Judge yourself 204 Judge yourself 208 The land of in- between: ethics of data presented at professional meetings 208 Judge yourself 213 Raw data, processed data, and data analysis: ways to go right and wrong 213 Summary 213 Discussion questions 215 Discussion questions 216 Chapter 12 Conflicts of Interest 217 The dynamic landscape of conflicts of interest 218 Potential conflicts of interest for university scientists 219 Judge yourself 226 Conflicts of interest within labs or universities 226 Judge yourself 228 Discussion questions 232 Discussion questions 237 Summary 238 Chapter 13 What Kind of Research Science World Do We Want? 239 A culture of discipline and an ethic of entrepreneurship 241 Judge yourself 243 Too much pressure? 243 Integrity awareness through ethics education 246 Accountability 246 Truth will win 247 We scientists 248 Summary 249 References 250 Index 256
£36.86
John Wiley & Sons Inc Pharma and Profits
Book SynopsisTable of ContentsAcknowledgments ix Introduction xChapter 1 The $1000 Pill: the Fiscal Consequences of Curing Hepatitis C 1 Chapter 2 Enter the Payers: Fda Approval Does Not Guarantee Commercial Success 10 Chapter 3 Pandemic: mRNA Vaccines And The Race For A Cure 19 Chapter 4 Federal Investment in R&d: Why the Government Does Not Deserve a Piece of Biopharma’s Profits? 34 Chapter 5 Insulin: the True Cost of a 100- Year- Old Drug 44 Chapter 6 The Costly Alzheimer’s Disease Drug: a Questionable Breakthrough 50 Chapter 7 Gene Therapy: How Much Is a Life Worth? 60 Chapter 8 Proving the Value of Expensive Drugs: Should We Pay For Drugs Whose Ultimate Value Is Unknown? 70 Chapter 9 Generic Drugs: Built- in Cost Controls 74 Chapter 10 About Those Soaring Pharma Profits: Are They Driving Healthcare Costs? 80 Chapter 11 Schemes to Lower Drug Prices: the Impact of Reduced Resources on R&d 84 Final Thoughts 96 Index 98
£18.36
Springer A Guide to Methods in the Biomedical Sciences
Book SynopsisThousands of methods have been developed in the various biomedical disciplines, and those covered in this book represent the basic, essential and most widely used methods in several different disciplines. Table of Contents1: Detection And Analysis Of Proteins A. Introduction B. Basic methods for protein analysis C. Characterization of primary, secondary, tertiary and quaternary structures of proteins 2: Detection And Analysis Of Nucleic Acids A. Introduction B. Basic methods for nucleic acid analysis C. DNA sequencing D. Detection and quantitation of RNA 3: Recombinant DNA Techniques: Cloning And Manipulation Of DNA A. Introduction B. Plasmid and viral vectors C. Libraries D. Site Directed Mutagenesis E. Polymerase chain reaction (PCR) F. Screening for differentially expressed genes (DEGs) G. Promoter-protein interactions H. Silencing gene expression I. Forensics and DNA technology 4: Antibody-Based Techniques A. Introduction B. Monoclonal antibodies C. Purification and use of antibodies D. Flow cytometry and fluorescence activated cell sorting (FACS) E. Other assays using antibodies 5: Microscopy: Imaging Of Biological Specimens A. Introduction B. Light microscopy C. Fluorescence and laser confocal microarray microscopy D. Electron Microscopy (EM) E. Magnetic resonance imaging (MRI) 6: The Derivation And Manipulation Of Experimental Animals In Biomedical Sciences A. Introduction B. Inbred strains of mice C. Congenic strains of mice D. Transgenic mice E. Targeted transgenes: 'knockout' and 'knockin' mice F. Other uses of mice in biomedical research References Some excellent methodology manuals Index
£85.49
Springer-Verlag New York Inc. Contemporary Topics in Analytical and Clinical Chemistry
Table of Contents1. Polychromatic Analysis Using the Technicon STAC™ Analyzer.- 1. Introduction.- 2. The STAC Analyzer.- 2.1. Diluter/Dispenser Module.- 2.2. Analytical Module.- 2.3. Electronics Module.- 3. General Theory.- 4. Selection of Primary and Secondary Wavelengths.- 5. Classification of Polychromatic Analysis.- 5.1. Correction for Nonreactive (Static or Time Invariant Interferences).- 5.2. Correction for Reactive (Kinetic) Interferences.- 5.3. Correction for a Combination of Both Reactive and Nonreactive Interferences.- 5.4. Detection of Substrate Depletion.- 6. STAC Assays.- 7. Examples of Polychromatic Analysis.- 7.1. Calcium.- 7.2. Total Bilirubin.- 7.3. Uric Acid.- 7.4. Triglycerides.- 7.5. AST.- 8. Conclusion.- References.- 2. Introduction to Multiple-Wavelength Spectrophotometric Measurements in Analytical and Clinical Chemistry.- 1. Introduction.- 2. Definitions.- 3. Applications in Analytical Chemistry.- 4. Applications in Clinical Chemistry.- 5. Epilogue.- References.- 3. Bichromatic Analysis: The Design and Function of the ABA-100.- 1. Introduction.- 2. Design Principles.- 3. Performance of Individual Instrument Functions.- 3.1. Photometric Uncertainty and Linearity.- 3.2. Control of Reaction Temperature.- 3.3. Sample Evaporation.- 3.4. Volume Measurement.- 3.5. Performance Characteristics Unique to Bichromatic Measurements.- 4. Automation of a Specific Method with the ABA.- 5. Quality Control.- 6. Special Applications.- 7. Epilogue.- References.- 4. Bichromatic Analysis as Performed in the Du Pont Automatic Clinical Analyzer (‘aca’).- 1. Introduction.- 2. Analytical Test Pack.- 2.1. Header.- 2.2. Pack Envelope.- 3. Instrument.- 3.1. Sample Handling/Pack Filling.- 3.2. Timing, Temperature, Reagent Addition/Mixing, and Incubation.- 4. Measurement System.- 4.1. Measurement Techniques.- 4.2. Electro-Optical System Description.- 4.3. Zero Absorbance Requirement.- 4.4. Output Result Performance and Calibration.- 5. Measurement Principles.- 5.1. Implementation.- 5.2. Representative Examples.- 5.3. Reaction Time Courses.- 5.4. Chromophore Spectra.- 5.5. Performance.- 6. Advantages.- 6.1. Disadvantages.- 6.2. Future Applications.- References.- 5. The Analysis of Matrix Formatted Multicomponent Data.- 1. Introduction.- 1.1. Data Reduction Strategies in Analytical Chemistry.- 1.2. Description of MFMDT.- 2. Linear Algebra Review.- 2.1. Vectors and Matrices.- 2.2. Arithmetic of Matrices.- 2.3. Matrix Solution of a System of Linear Equations.- 2.4. Basis and Rank.- 2.5. Identity and Inverse Matrices.- 2.6. Eigenvalues and Eigenvectors.- 2.7. Glossary.- 3. Theory and Application of MFMDT in Qualitative Analysis of the Fluorescence Emission-Excitation Matrix (FEEM).- 3.1. Properties of Fluorescence Emission.- 3.2. Principles of Qualitative Analysis of the FEEM by MFMDT.- 3.3. Qualitative Analysis of Simulated Fluorescence Data.- 3.4. Qualitative Analysis of Experimental Fluorescence Data.- 4. Theory and Application of MFMDT in Quantitative Analysis of the FEEM.- 4.1. Theory of Least Squares Analysis of the FEEM.- 4.2. Theory of Linear Programming Analyses (Simplex Method) of the FEEM.- 4.3. Quantitative Analysis of Simulated Fluorescence Data.- 4.4. Quantitative Analysis of Experimental Fluorescence Data.- 5. Summary and Conclusion.- 5.1. Effectiveness of MFMDT for Analysis of Multicomponent Fluorescence Data.- 5.2. Expansion and Future Applications of MFMDT.- 6. Appendices.- 6.1. Fortran Subroutines for Qualitative Analysis.- 6.2. Fortran Subroutines for Quantitative Analysis.- References.- 6. Nonlinear Parameter Estimation of Convolved Excitation and Multiple Emission Response Functions.- 1. Introduction.- 1.1. Luminescence Processes.- 1.2. Modern Instrumentation.- 1.3. Algorithms for Nonlinear Data Analysis.- 2. Instrumentation and Analytical Parameters.- 2.1. Time Correlated Single-Photon Method.- 2.2. Theory.- 2.3. Pile-Up.- 2.4. Time-to-Amplitude Converter.- 2.5. Excitation Source.- 2.6. Optics.- 2.7. Photomultiplier Tube.- 2.8. Start and Stop Lines.- 2.9. Timing Filter Amplifier (TFA).- 2.10. Analytical Considerations— Intensity versus Concentration.- 2.11. Scattered Excitation Radiation.- 2.12. Analytical Wavelength and Bandpass Selection.- 2.13. Linearity versus Concentration.- 3. Data Handling.- 3.1. Theory and Description of the Algorithms.- 3.2. Grid Search Algorithms (GSA).- 3.3. Moments Algorithm (MA).- 3.4. Marquardt’s Algorithm (MQA).- 4. Experimental.- 4.1. Data Sources.- 5. Results and Discussion.- 5.1. Simulated Data—GSA.- 5.2. Simulated Data—MA.- 5.3. Simulated Data—MQA.- 5.4. Comparison of Convergence Characteristics for MQA and MA.- 5.5. Convergence Rate and Efficiency.- 5.6. Fluorescence Data.- 6. Summary.- References.- 7. ESCA Studies of Electrode Surfaces.- 1. Introduction.- 2. Electrode Transfer.- 2.1. The Possibilities for Film Change and Decomposition During Transfer.- 2.2. The Anaerobic Transfer Electrochemical Cell.- 3. Data Analysis.- 4. Carbon and Related Electrodes.- 5. Electrodes Involving Magnesium and Aluminum.- 5.1. Detection of Precipitation of Magnesium Hydroxide.- 5.2. Effect of Ions on the Anodic Oxide Films on Aluminum.- 5.3. Anodization of Aluminum in Liquid Hydrogen Fluoride.- 6. Electrodes Involving Titanium.- 6.1. Titanium Metal and Alloys.- 6.2. Titanium Dioxide and Related Electrodes.- 7. Vanadium Pentoxide Electrodes in Reserve Cells.- 8. Electrodes Involving Chromium.- 9. The Manganese Dioxide Electrode.- 10. Electrodes Involving Iron.- 10.1. Studies of Metallic Iron.- 10.2. Studies of Iron Alloys.- 10.3. Studies of Stainless Steel.- 11. Electrodes Involving Nickel.- 11.1. Studies of Nickel Metal.- 11.2. Studies of Molten Salt Systems.- 11.3. Studies of Nickel Alloys.- 12. Electrodes Involving Copper.- 12.1. Cu(I) Oxide Solar Cells.- 12.2. Corrosion Inhibition of Copper.- 12.3. Studies of Copper Alloys.- 13. Electrodes Involving Zinc.- 14. The Niobium Electrode.- 15. The Molybdenum Electrode.- 16. Ruthenium Dioxide-Based Film Electrodes.- 17. Electrodes Involving Tantalum.- 18. Electrodes Involving Tungsten.- 19. Electrodes Involving Tin.- 19.1. Studies of Oxidized Tin Surfaces.- 19.2. Studies of the Anodic Polarization of Metallic Tin.- 19.3. Studies of Tinplate.- 19.4. Studies of Tin Alloys.- 20. The Study of Anodic Oxide Films on Gallium Arsenide and Related Compounds.- 21. Chemically Modified Electrodes.- 21.1. Modified Electrodes.- 21.2. Modified Electrodes with Covalently Bonded Species.- 22. Studies of Solid Electrolytes.- 23. Ion-Selective Electrodes.- 24. Noble Metal Electrodes.- 24.1. Studies of Oxide Films on Platinum Electrodes.- 24.2. Studies of Sulfide Films on Platinum Electrodes.- 24.3. Studies of Platinum Electrodes in Molten Salt Systems.- 24.4. Electro-Oxidation in Platinum Systems.- 24.5. Underpotential Deposition on Platinum Electrodes.- 24.6. Studies of Lead Oxidation on a Platinum Electrode.- 24.7. Studies of Oxide Films on Gold Electrodes.- 24.8. Studies of Oxide Films on Palladium Electrodes.- 24.9. Studies of Oxide Films on Iridium Electrodes.- 24.10. Studies of Mixed Noble Metal Systems.- 25. Trace Metal Analysis.- 26. Studies of Paint Films.- 27. AES Studies of Electrode Surfaces.- 28. Conclusion.- References.- 8. Spatially Resolved Spectroscopy: Theory and Applications of the Abel Inversion.- 1. Introduction.- 2. Fundamentals.- 3. Computation of Area Matrices.- 4. Abel Inversion of Strictly Emitting Profiles.- 5. Self-Absorption and the Abel Inversion—Theory.- 6. Self-Absorption and the Abel Inversion—Examples.- 7. Background Correction in the Presence of Self-Absorption.- 8. Instrumental Misalignment and Spark Wander.- 9. Summary on Wander.- 10. True Measurement Noise.- 11. Spatially Unseparated Emission and Absorption.- 12. Conclusion.- 13. Appendix.- References.
£40.49
Springer-Verlag New York Inc. Space Pharmacology
Book SynopsisSpace Pharmacology is a review of the current knowledge regarding the use of pharmaceuticals during spaceflights. Every section begins with a topic overview, and is followed by a discussion of published data from spaceflight, and from ground experiments meant to model the spaceflight situation.Table of ContentsChapter 1: Introduction.- Chapter 2: Absorption.- Chapter 3: Distribution.- Chapter 4: Metabolism and Excretion.- Chapter 5: Central Nervous System.- Chapter 6: Cardiovascular System.- Chapter 7: Gastrointestinal System.- Chapter 8: Musculoskeletal System.- Chapter 9: Multiple Systems Spaceflight Effects.- Chapter 10: Conclusions - Special Challenges of Long Duration Exploration.- References.- Abbreviations.
£49.49
Headline Publishing Group Cannabis is Medicine
Book SynopsisIn Cannabis Is Medicine, medical cannabis specialist Bonni Goldstein, MD, explains the science behind the use of this amazingly therapeutic plant and describes in easy-to-understand detail the recently discovered endocannabinoid system, involved in almost every human physiological process. Over 4 million people in the US are healing difficult-to-treat illnesses with cannabis medicine, and although 33 states have medical cannabis laws, many physicians remain reluctant to discuss how this plant may be beneficial to health. this book is the comprehensive resource for patients and their loved ones who have not found answers with conventional medicines.Dr Goldstein has helped thousands of suffering patients -- including children -- find relief with cannabis. In her revelatory book, she explains the current state of scientific research on more than 28 chronic medical conditions that have responded positively to treatment with cannabis, and offers actionable adTrade ReviewDr. Goldstein sets the record straight on cannabis, offering an in-depth, scientific look at the potent healing power of this much-maligned plant. Anyone considering cannabis medicine for themselves or a loved one needs to read this book. * Mark Hyman, MD, author of Food: What the Heck Should I Eat? *Cannabis Is Medicine tells it like it is. For far too long the important medicinal potential of the cannabis plant has been at least overlooked, and at worst, aggressively stigmatized. The incredible potential of cannabis derivatives across a wide panorama of medical conditions is now widely embraced by highly respected science. And Dr. Bonni Goldstein has done a magnificent job of eloquently presenting this science to augment our tools as healthcare providers as well as for consumers at large. A powerful validation of the healing properties of cannabis. * David Perlmutter, MD, bestselling author of Grain Brain and Brain Wash *
£15.29
Humana Press Inc. TRP Channels
Book SynopsisThis book aims to provide a guide to researchers on how to work with Transient Receptor Potential (TRP) channels, describing current methodologies and protocols, and highlighting the challenges ahead that will require the development of new technologies. Articles cover a wide range of techniques, from structure to function, concluding with how to best to evaluate some of the in vivo function of TRP channels, particularly in regard to their involvement in hyperalgesia and allodynia. Also, the collection describes important and inspiring available tools that are currently being used to investigate the activity of these channels in vitro and in vivo in terms of their underlying protein structure, segueing into dealing with the generation of pharmacological tools to explore their in vivo activity and their involvement in cellular signaling pathways, which may be developed into drugs to treat diseases caused by channel dysfunction or hyperactivity. Written for the highly successful MethoTable of Contents1. Molecular Evolution Bioinformatics towards Structural Biology of TRPV1-4 Channels Pau Doñate-Macián, Alba Crespi-Boixader, and Alex Perálvarez-Marín 2. Expression, Purification, and Crystallization of the Transient Receptor Potential Channel TRPV6 Appu K. Singh, Luke L. McGoldrick, and Alexander I. Sobolevsky 3. Cryo-Electron Microscopy of TRP Channels Amrita Samanta, Taylor E.T. Hughes, and Vera Y. Moissenkova-Bell 4. Mass Spectrometry-Based Analysis of TRPP2 Phosphorylation Verónica I. Dumit, Michael Köttgen, and Alexis Hofherr 5. Combining Structural Data with Computational Methodologies to Investigate Structure-Function Relationships in TRP Channels Victoria Oakes and Carmen Domene 6. Characterization of TRPC Channels in a Heterologous System Using Calcium Imaging and the Patch-Clamp Technique Elvira de la Peña and Ana Gomis 7. Fluorescence-Based Functional Assays for Ca2+ Permeable ThermoTRP Channels Celia Cordero-Sánchez, Irene Mudarra-Fraguas, and Asia Fernández-Carvajal 8. High Content Imaging of Immunofluorescently-Labeled TRPV1-Positive Sensory Neurons Jörg Isensee and Tim Hucho 9. Patch-Clamp Combined with Fast Temperature Jumps to Study Thermal TRP Channels Beiying Liu and Feng Qin 10. TRP Channels Reconstitution in Lipid Bilayers Eleonora Zakharian 11. Methods for Investigating TRP Channel Gating Osvaldo Alvarez, Karen Castillo, Emerson Carmona, Carlos Gonzalez, and Ramon Latorre 12. In Silico Approaches for TRP Channel Modulation Magdalena Nikolaeva Koleva and Gregorio Fernández-Ballester 13. Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction Tracey Pirali, Ubaldina Galli, Marta Serafini, Alessia Griglio, Armando A. Genazzani, and Gian Cesare Tron 14. In Vivo Methods to Study ThermoTRP Channels in Rodents Sara González-Rodríguez
£123.49
Hodder & Stoughton Dopeworld: Adventures in Drug Lands
Book SynopsisWelcome to Dopeworld. Ecstasy in London, crack in Los Angeles, LSD in Tokyo, heroin in Sofia, cocaine in Medellin, bounty hunting in Manilla, opium in Tehran. Get ready for your next fix. __________Dopeworld is a bold and intoxicating journey into the world of drugs. From the cocaine farms in South America to the streets of Manila, we trace the emergence of psychoactive substances and our intimate relationship with them. With unparalleled access to drug lords, cartel leaders, street dealers and government officials, Niko Vorobyov attempts to shine a light on the dark underbelly drug world.At once a bold piece of reportage and a hugely entertaining and perverse travelogue, Dopeworld reveals how drug use is at the heart of our history, our lives, and our world.__________ With echoes of Gomorrah and Fear and Loathing in Last Vegas, Dopeworld is a brilliant and enlightening journey across the world, examining every angle of the drug war.
£10.44
Nova Science Publishers Inc Advances in Medicinal Chemistry Research
Book SynopsisAdvances in Medicinal Chemistry Research is a book addressed to undergraduate and postgraduate students, where recent advances in the discovery and development of effective agents against the most remarkable wide-reaching diseases are presented, divided into seven chapters. This first edition of Advances in Medicinal Chemistry Research offers insights into medicinal chemistry that arguably have the most significant impact on our lives than any other. It draws together research on therapeutic agents from natural, synthetic, and virtual screening sources as starting points for the design of drugs against obesity, multidrug-resistant bacteria, neglected tropical diseases, Alzheimer, and cancer. From the prediction of promising hits and identification of active compounds to the extraction of more complex molecules, this book explores a range of essential topics to support the development of novel, economical, and efficacious therapeutics for these diseases, which currently affect a billion people worldwide. Beginning with an overview of obesity, showing the current research landscape, the books shows the importance of natural and synthetic products as promising anti-obesity agents. Subsequently, the medicinal chemistry of modulation of bacterial resistance is presented, focusing on the MFS, RND, ABC, and MATE superfamilies. The book goes on to discuss such topics as antituberculosis, antileishmanial, and anti-hepatitis thiophene-containing compounds, under the medicinal chemistry point of view. Also, potent human glutaminyl cyclase inhibitors are deeply discussed and displayed as hopeful anti-Alzheimer's agents. The last three chapters are focused on the development of researches involving new anticancer agents, initializing with LBDD, SBDD, QSAR, and QM/MM methods applied to the identification of novel promising anticancer compounds. Moreover, IDO1 inhibitors are exhaustively explored and analyzed as a new promise for the immunotherapy of cancer. Finally, a great update on Eg5 kinesin inhibitors is provided, exploring different chemical classes of synthetic and natural compounds, including miscellanea as a new approach for Eg5 inhibition. Combining the expertise of researchers from around the world, this volume aims to support and encourage researches for the development of novel, safe, and active agents against lipase enzyme, bacteria, neglected tropical diseases, Alzheimer, and cancer. The clear narrative truly engages the reader, holding their attention right from the opening of a chapter, and maintaining interest and understanding as a chapter leads into more complex material. Advances in Medicinal Chemistry Research is a book that reviews ongoing developments and recent cutting-edge advances in medicinal chemistry of the most relevant diseases found nowadays, underlining how medicinal chemistry research continues to make significant contributions to the discovery and development of new therapeutic entities. Key Features Chapters written by active specialists and leading experts deeply engaged in the research field of most deadly and limiting diseases for drug discovery. Draws together cutting-edge research advances in medicinal chemistry focused at the obesity, multidrug-resistant microorganisms, Alzheimer, and cancer in a single volume. Highlights the future potential of researches for the medicinal chemistry of most impactful diseases today. Contents addressed to medicinal chemistry, biochemistry, biology, and pharmacy students, professors, and researchers.
£138.39
Nova Science Publishers Inc Antimicrobial Resistance: Opportunities and
Book SynopsisThis book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms. The book intends to provide a state-of-the-art collection of reviews and methods for both basic and clinician investigators who are interested in multidrug resistance mechanisms and reversal strategies. We believe that this information will be of value to clinicians, epidemiologists, microbiologists, virologists, parasitologists, public health authorities, medical students, and fellows in training. Each chapter begins with a summary of the concepts, so that those not actively working in the field can readily gain an overall picture of what follows. The book contains 13 chapters which deal with the antibiotic resistance mechanism in bacteria, fungus, virus and also methicillin resistance S.aureus. The book also explains the futuristic strategy to deal with the antibiotic resistance. We have endeavoured to provide this information in a style that is accessible to the broad community of persons who are concerned with the impact of drug resistance in our clinics and across broader global communities.Table of ContentsPreface; History of Drug-Resistant Microbes; Mechanism of Antibiotic Resistance in Bacteria; Infectious Pathogens, Pathogenesis, Antimicrobial Therapy, Antimicrobial Resistance, and Surveillance Measures; Fungal Resistance to Antibiotics; Antibiotic Resistance and Tolerance in Bacterial Biofilm; Methicillin Resistant Staphylococcus aureus (MRSA): An Overview; Mechanism of Drug Resistance in Mycobacterium tuberculosis; Viral Drug Resistance; Strategies for Circumventing Antimicrobial Resistance; Metallic Nanoparticles in Tackling of Antimicrobial Resistance; Plant Antimicrobials: An Alternative for Overcoming Microbial Resistance; Algae: Novel Cell Factories for Antimicrobial Compounds to Overcome Antibiotic Resistance; Microbial Resistance: A Worldwide Public Health Problem; Index.
£163.19
Nova Science Publishers Inc Formaldehyde: Synthesis, Applications & Potential
Book Synopsis
£163.19
Royal Society of Chemistry Protein–Protein Interaction Regulators
Book SynopsisNew genomic information has revealed the crucial role that protein–protein interactions (PPIs) play in regulating numerous cellular functions. Aberrant forms of these interactions are common in numerous diseases and thus PPIs have emerged as a vast class of critical drug targets. Despite the importance of PPIs in biology, it has been extremely challenging to convert targets into therapeutics and targeting PPIs had long been considered a very difficult task. However, over the past decade the field has advanced with increasing growth in the number of successful PPI regulators. Protein–Protein Interaction Regulators surveys the latest advances in the structural understanding of PPIs as well as recent developments in modulator discovery.Table of ContentsIntroduction; Protein-protein interaction interfaces and their functional implications; Protein-Protein interaction networks in human disease; High Throughput Screening Methods for PPI inhibitor discovery; Computational structural modeling to discover PPI modulators; Small molecule inhibitors of E3 ubiquitin ligases; Hydrogen bond surrogate stabilized helices as Protein-Protein interaction inhibitors; Helix-mimetics as Protein-Protein Interaction Inhibitors; Discovery and Development of Mcl-1 Inhibitors as Anti-cancer Therapeutics: Hit to Clinical Candidate Optimization; Pharmacological Regulation and Functional Significance of Chromatin Binding by BET Tandem Bromodomains; Small-molecule modulators of Protein-Protein Interactions: focus on 14-3-3 PPIs; Discovery of AMG 232, a small molecule MDM2 inhibitor in clinical development and its back-up clinical candidate, AM-7209; Small Molecule Inhibitors of Myc-Max Interaction and DNA Binding; Small Molecule Modulators of Endo-Lysosomal Toll-Like Receptors
£151.05
Royal Society of Chemistry The Handbook of Medicinal Chemistry: Principles
Book SynopsisCompletely revised and updated, the 2nd edition of The Handbook of Medicinal Chemistry draws together contributions from authoritative practitioners to provide a comprehensive overview of the field as well as insight into the latest trends and research. An ideal companion for students in medicinal chemistry, drug discovery and drug development, while also communicating core principles, the book places the discipline within the context of the burgeoning platform of new modalities now available to drug discovery. The book also highlights the role chemistry has to play in wider target validation and translational technologies. This is a carefully curated compilation of writing from global experts using their broad experience of medicinal chemistry, project leadership and drug discovery and development from an industry, academic and charity perspective to provide unparalleled insight into the field.Table of ContentsPhysicochemical Properties; Synthesis in Medicinal Chemistry; Useful Computational Chemistry Tools for Medicinal Chemistry; Structure-based Design for Medicinal Chemists; Fragment-based Ligand Discovery; Machine Learning in Drug Design; Drug Metabolism; ADME Optimization in Drug Discovery; Molecular Biology for Medicinal Chemists; Assays; In Vitro Biology: Measuring Pharmacological Activity That Will Translate to Clinical Efficacy; Animal Models: Practical Use and Considerations; Bioinformatics for Medicinal Chemistry; Translational Science; Discovery Toxicology in Lead Optimization; Toxicology and Drug Development; Patents for Medicines; Target Validation for Medicinal Chemists; Lead Optimisation: What you should know!; Pharmaceutical Properties – The Importance of Solid Form Selection; The Medicinal Chemistry and Process Chemistry Interface; Clinical Drug Development; SMN2 Splicing Modification by Small Molecules – A Blueprint to Tackle the Underlying Genetic Cause of Many Underserved Diseases; The Discovery of Checkpoint Kinase 1 Inhibitors: From Fragments to Clinical Candidate; Medicinal Chemistry for Neglected Diseases – Malaria, Tuberculosis, Sleeping Sickness, Leishmaniasis and River Blindness; New Therapeutic Chemical Modalities: Compositions, Modes-of-action, and Drug Discovery
£90.25
Royal Society of Chemistry Cheminformatics and Bioinformatics at the
Book SynopsisThe cost of drug development is increasing, and investment returns are decreasing. The number of drugs approved by FDA is in decline in terms of the number of new molecular entities (NMEs). Amongst the reasons noted for this are the adverse side effects and reduced efficiency of many of the potential compounds. This is a problem both for the pharmaceutical industry and for those suffering from diseases for which there are no or few available treatments. Advances in computational chemistry, computer science, structural biology and molecular biology have all contributed to improved drug design strategies and reduced the time taken for drug discovery. By interfacing cheminformatics and bioinformatics with systems biology we can create a powerful tool for understanding the mechanisms of patho-physiological systems and identifying lead molecules for various diseases. This integration of drug design approaches can also play a crucial role in the prediction and rationalization of drug effects and side effects, improving safety and efficacy and leading to better approval rates. Addressing the lack of knowledge on the fundamental aspects of the various computational tools for drug discovery, this book is a compilation of recent bioinformatics and cheminformatics approaches, and their integration with systems biology. Written primarily for researchers and academics in chem- and bioinformatics, it may also be a useful resource for advanced-level students.Table of ContentsSystem Biology and Drug Target Identification;Modulating Drug Target Gene Expression in Cancer;Drug Repositioning Using Genome-wide Screening and Systems Biology Approaches and Applications;New Directions in System Biology-based Target Identification and Cancer Genome Analysis;Molecular Investigation of Protein–Protein Interaction Candidates Related to Mammalian Brain;Biological Systems to Computational Systems Biology;Controlled Vocabularies and Semantics in Systems Biology;Single-molecule Imaging in Biosystems;Tracking the Emergence of Synthetic Biology;Synthetic Biology: Fostering the Cyber-biological Revolution;Computational Systems Chemical Biology;Systems Biology Methods to Assist in the Discovery of Efficacious Drug Combinations
£151.05
Royal Society of Chemistry Specialised Pharmaceutical Formulation: The
Book SynopsisFormulation is a key step in the drug design process, where the active drug is combined with other substances that maximise the therapeutic potential, safety, and stability of the final medicinal product. Regulatory and quality demands, in addition to advances in processing technologies, result in growing challenges as well as possibilities for the field. Following on from Pharmaceutical Formulation, which covered traditional dosage forms such as tablets and capsules, this volume expands upon those formulations to cover a more diverse range of less common dosage forms. Novel routes of administration are covered from inhalational, dermal and transdermal formulations to ocular, oral suspensions, vaccines and nanoparticle drug delivery. The methods through which these formulations are processed and manufactured is also covered, providing essential knowledge to ensure quality, efficiency, and acceptable costing. Specialised Pharmaceutical Formulation is an essential, up to date resource for students and researchers working in academia and in the pharmaceutical industry and will equip readers with the ability to effectively and reliably produce products which can be approved, manufactured and made available to administer to patients.Table of ContentsOphthalmic Formulation; Parenteral Products; Dermal Formulations for Local Treatment; Transdermal Drug Delivery; Oral Suspensions; Oral Films; Inhalation Devices and Formulations; Advanced Therapy Medicinal Products (ATMPs); Geriatric Pharmaceutics; Development Programs for Oral Fixed Dose Combination Products; Presentational and Organoleptic Aspects of Formulation; Formulation and Processing for Powder Sachets
£160.55
Royal Society of Chemistry Active Site-directed Enzyme Inhibitors: Design
Book SynopsisOur biological system is enriched with enzyme-catalyzed (or enzymatic) reactions that mediate a great multitude of life processes such as gene transcription and metabolism, and the inappropriately up-regulated activity of these enzymatic reactions is a major cause of human diseases such as cancer and metabolic diseases. Therefore, the inhibitors of enzymatic reactions (generally called enzyme inhibitors) constitute a major class of therapeutic agents on the global drug market. One question would then be how to efficiently design enzyme inhibitors. This handbook is the first of its kind in the field, introducing to its readers in a single book the concepts whose exploitation has been demonstrated to be successful in efficiently furnishing effective active site-directed inhibitors for various enzymatic reactions. The book is organized by different concepts and for each concept there is a delineation of its mode of working and its applications with different types of enzymatic reactions. Active Site-directed Enzyme Inhibitors will help its readers to quickly and efficiently obtain effective active site-directed inhibitors for any of the enzymatic reactions under study without a need to resort to library screening- and biostructure-based techniques. This handbook is ideal as an immediate resource for researchers to consult or for students to supplement their study in medicinal chemistry and related courses.Table of ContentsCatalytic Mechanism-based Design;Catalytic Intermediate-based Design;Substrate-based Design;Transition State-based Design;(Photo)Affinity Label and Covalent Inhibitor Design; Proteolysis Targeting Chimera (PROTAC) Design
£118.75
Royal Society of Chemistry Implantable Technologies: Peptides and Small
Book SynopsisImplantable technologies allow for a sustained control over the release of pharmaceuticals into the bloodstream thereby achieving a controlled concentration with the potential to minimise side-effects while increasing patient compliance. Significant progress has been made in various alternative implantable delivery technologies, notably in intraocular and subcutaneous devices. Despite success in research and clinical studies, long-term clinical efficacy may be more limited and different aspects related to drug development and commercialization using these technologies are not well understood or practiced in the commercial setting. This book provides a comprehensive and cohesive picture of the latest in the field while also outlining the opportunities and challenges in implantable technology. Implantable Technologies: Pepties and Biologic Drug Development is an ideal reference for any postgraduate or researcher interested in utilising implantable technologies and novel routes of drug administration. The book will also be of interest to those involved in formulation and clinical application for a wide array of disease areas in addition to more established paradigms such as diabetes and pain management.Table of ContentsStatus of Implantable and Long-acting Injectable Technologies; Developing Complex Dosage Forms of Long- acting Biologics for the Eye: Current State, Challenges, and Opportunities; Monolithic Devices for Sustained Delivery of Protein Therapeutics for Ocular Disease; Sustained Delivery of Ocular Protein Therapeutics; Development of Risperidone Implant Formulations (DLP-114) for Long-term Maintenance Treatment of Schizophrenia; In-line Extrusion Process and Product Evaluation of ProNeura® by Near-infrared Spectroscopy; Addressing Immunogenicity for Implantable Drug-delivery Devices and Long-acting Injectables, Including Pharmacokinetic and Pharmacodynamic Correlations; Characterization Methods for Parenteral Peptide Controlled Release Drug Delivery Systems; Parenteral Delivery of Therapeutic Proteins, Peptides and Small Molecules Using Biodegradable Silica; Development of User-initiated Vaginal Dosage Forms; Three-dimensional Printed Implantable Products;
£151.05
Royal Society of Chemistry Alzheimer's Disease: Recent Findings in
Book SynopsisAlzheimer’s disease is an increasingly common form of dementia and despite rising interest in discovery of novel treatments and investigation into aetiology, there are no currently approved treatments that directly tackle the causes of the condition. Due to its multifactorial pathogenesis, current treatments are directed against symptoms and even precise diagnosis remains difficult as the majority of cases are diagnosed symptomatically and usually confirmed only by autopsy. Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities provides a comprehensive overview from aetiology and neurochemistry to diagnosis, evaluation and management of Alzheimer's disease, and latest therapeutic approaches. Intended to provide an introduction to all aspects of the disease and latest developments, this book is ideal for students, postgraduates and researchers in neurochemistry, neurological drug discovery and Alzheimer’s disease.Table of ContentsAlzheimer’s is a Multifactorial Disease; The Genetic and Biochemical Basis of Alzheimer’s Disease; Alzheimer’s Disease Pathology: A Tau Perspective; Structural Insights Into the Amyloidogenic Ab and Tau Species in Alzheimer’s disease Pathophysiology: Defining Functional Motifs for Therapeutic Interventions; Structural Insights on Aggregation Species of Ab and Tau, and Their Implications in Alzheimer’s Disease; Aggregation Species of Amyloid-b and Tau Oligomers in Alzheimer’s Disease: Role in Therapeutics and Diagnostics; Role of Metal Ions in Alzheimer’s Disease: Mechanistic Aspects Contributing to Neurotoxicity; Microglial Blockade of the Amyloid Cascade: A New Therapeutic Frontier; Post-translational Modifications and Alzheimer’s Disease; Autophagy: Role in Alzheimer’s Disease Pathophysiology and Therapeutic Avenues; Transmission of Pathogenic Proteins and the Role of Microbial Infection in Alzheimer’s Disease Pathology; The Role of Gut Microbiome in Alzheimer’s Disease and Therapeutic Strategies; Molecular Probes for the Diagnosis of Alzheimer’s Disease with Implications for Multiplexed and Multimodal Strategies; Circulating Biomarkers for the Diagnosis of Alzheimer’s Disease; Lactoferrin: A Potential Theranostic Candidate for Alzheimer’s Disease; Multifunctional Inhibitors of Multifaceted Ab Toxicity of Alzheimer’s Disease; Tau-targeting Therapeutic Strategies for Alzheimer’s Disease; Computational Development of Alzheimer’s Therapeutics and Diagnostics; Targeted Protein Degradation as a Therapeutic Avenue for Alzheimer’s Disease; Cell-based Therapy for Alzheimer’s Disease; Experimental Models to Study Alzheimer’s Disease; Ethnic and Racial Differences in The Pathophysiology of Alzheimer’s Disease
£189.99
Springer Nature Switzerland AG Handbook of Space Pharmaceuticals
Book SynopsisThis handbook, directed at medical professionals and students who are involved in developing the space industry or are academicians doing research in this area, covers current pharmaceutical knowledge about the difference in medication efficacy in space versus on Earth and includes trial results and best practices for the space research and travel industry. The well-known contributors come from an interdisciplinary background and address all aspects of the subject, from the physiological impact of spaceflight to the effects of radiation.As the commercial space industry expands its operations in industry and tourism, the field of space pharmaceuticals is growing commensurately. Existing pharmacological research from space is thoroughly covered in this book, and Earth applications are also described. Potential pharmacological solutions are posed along with the known challenges and examples from existing studies, which are detailed at length. This major reference work is a comprehensive and important medical resource for all space industry players.Table of ContentsSection I: Principles of Pharmaceuticals.- Section II: Effects of Spaceflight on Human Physiology and its Consequences on Drug Treatment.- Section III: Model Organisms for Pharmaceutical Research in Space.- Section IV: Simulated Microgravity for Pharmaceutical Research.- Section V: Translating Knowledge from Spaceflight Research to Earth Applications.- Section VI: Nutritional and Alternative Approaches to Treatment in Space.
£522.49
Springer Nature Switzerland AG Essential Pharmaceutics
Book SynopsisParticularly in healthcare fields, there is growing movement away from traditional lecture style course towards active learning and team-based activities to improve learning and build higher level thinking through application of complex problems with a strong foundation of facts and data. Essential Pharmaceutics is suited to this modern teaching style, and is the first book of its kind to provide the resources and skills needed for successful implementation of an active learning pharmaceutics course.This text offers a format that is specifically suited for integration in an active learning, team-based classroom setting. It is ideal for self-learning for the beginning pharmaceutics student, based upon the extensive utilization of figures, tables, and its overview of essential topics in pharmaceutics. Also unique to this text is the integration of case studies based upon modern pharmaceutical products which are designed to reinforce importance pharmaceutical concepts and teach essential skills in literature review and patent searching. Case studies covering all topics covered in the text have been developed by the authors that allow application of the content in the flipped-classroom pharmaceutical course.Table of ContentsPreface:Designing a Flipped-Classroom Pharmaceutics Course.- Guide to Patent and Literature Searching in Pharmaceutics.- Preformulation.- Capsules and Tablets.- Modified Release Solid Oral Dosage Forms.- Solution-Based Dosage Forms and Sterile Products .- Suspensions.- Emulsions.- Ophthalmic Delivery.- Nasal Dosage Forms.- Topical and Transdermal Dosage Forms.- Suppositories and Inserts.- Pulmonary Drug Delivery .- Regulations in Drug Product Development.
£49.49
Springer Nature Switzerland AG Cannabis Laboratory Fundamentals
Book SynopsisThe legislative requirement for cannabis to undergo laboratory testing has followed legalization of medical and recreational use in every U.S. state to date. Cannabis safety testing is a new investment opportunity within the emerging cannabis market that is separate from cultivation, processing, and distribution, allowing individuals and organizations who may have been reluctant to enter previously a new entry route to the cannabis space. However, many of the costs, timelines, operational requirements, and compliance issues are overlooked by people who have not been exposed to regulated laboratory testing. Cannabis Laboratory Fundamentals provides an in-depth review of the key issues that impact cannabis testing laboratories and provides recommendations and solutions to avoid common – but expensive – mistakes. The text goes beyond methodology to include sections on economics, regulation, and operational challenges, making it useful for both new and experienced cannabis laboratory operators, as well as all those who want to understand the opportunities and risks of this industry.Table of Contents1. An Introduction to Cannabis Laboratory Safety and Compliance Testing 2. Cannabis Safety Testing Laboratory Floor Planning & Design 3. Laboratory Safety from Site Selection to Daily Operation 4. Preparing Cannabis Laboratory Business License Applications 5. Quality Assurance and the Cannabis Analytical Laboratory 6. Cannabis Laboratory Management: Staffing, Training and Quality 7. Laboratory Information Management Systems (LIMS) 8. Pesticide and Mycotoxin Detection and Quantitation 9. Cannabinoid Detection and Quantitation 10. Utilizing GC-MS and GC Instrumentation for Residual Solvents in Cannabis and Hemp 11. Elemental Analysis of Cannabis and Hemp – Regulations, Instrumentation, and Best Practices 12. Quantitative Terpene Profiling from Cannabis Samples 13. Laboratory Safety and Compliance Testing for Microorganism Contamination in Marijuana
£71.24
Springer Nature Switzerland AG Physician's Guide to the Diagnosis, Treatment,
Book SynopsisThis updated and enlarged second edition is a unique source of information on the diagnosis, treatment, and follow-up of metabolic diseases. The clinical and laboratory data characteristic of rare metabolic conditions can be bewildering for clinicians and laboratory personnel alike – reference laboratory data is scattered, and clinical descriptions can be obscure. The new Physician’s Guide with the additional more than 600 diseases now featured, documents 1200 conditions grouped according to type of disorder, organ system affected (e.g. liver, kidney, etc) or phenotype (e.g. neurological, hepatic, etc). It includes relevant clinical findings and highlights the pathological values for diagnostic metabolites. Guidance on appropriate biochemical genetic testing is also provided and established experimental therapeutic protocols are described, with recommendations on follow-up and monitoring. The authors are acknowledged experts, and the book is a valuable desk reference for all who deal with inherited metabolic diseases.Chapter 73 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.comTable of ContentsPart 1. GENERAL SUBJECTS AND PROFILES.- 1. Newborn Screening for Inborn Errors of Metabolism.- 2. Simple Tests and Routine Chemistry.- 3. Amino Acids.- 4. Organic Acids.- 5 .Acylcarnitines.- 6. Lysosomals.- 7. Untargeted Metabolomics – Next Generation Metabolic Screening.- 8. MRI and In Vivo Spectroscopy of the Brain.- 9. Genomic Approaches for the Diagnosis of Inborn Errors of Metabolism.- 10. Other-omics Approaches and Their Integration for the Diagnosis and Treatment of Inborn Errors of Metabolism.- 11. Emergency Diagnostic Procedures and Emergency Treatment.- 12. Nosology of Inborn Errors of Metabolism.- Part 2. DISORDERS OF NITROGEN-CONTAINING COMPOUNDS.- 13. Purine and Pyrimidine Disorders.- 14. Disorders of nucleotide metabolism.- 15. Disorders of Creatine Metabolism.- 16. Disorder of Glutathione Metabolism.- 17. Disorders of Ammonia Detoxification.- 18. Amino Acid Transport Defects.- 19. Disorders of Monoamine Metabolism.- 20. Disorders of Phenylalanine and Tetrahydrobiopterin Metabolism.- 21. Disorders of Tyrosine Metabolism.- 22. Disorders of Sulfur Amino Acid and Hydrogen Sulfide Metabolism.- 23. Disorders of Branched-Chain Amino Acid Metabolism.- 24. Disorders of Beta and Gamma Amino Acids.- 25. Amino Acid Synthesis Deficiencies.- 26. Disorders of Glycine Metabolism.- 27. Disorders of Lipoic Acid and Iron-Sulfur Protein Metabolism.- Part 3. DISORDERS OF VITAMINS, COFACTORS, METALS AND MINERALS.- 28. Disorders of Cobalamin Metabolism.- 29. Disorders of Folate Metabolism and Transport.- 30. Disorders of Biotin Metabolism.- 31. Thiamine Disorders.- 32. Disorders of Riboflavin Metabolism.- 33. Disorders of Niacin, NAD and Panthotenate Metabolism.- 34. Vitamin B6-Dependent and Responsive Disorders.- 35. Molybdenum Cofactor Disorders.- 36. Disorders of Copper, Zinc and Selenium Metabolism.- 37. Disorders of Iron Metabolism.- 38. Disorders of Manganese Metabolism.- Part 4. DISORDERS OF CARBOHYDRATES.- 39. Disorders of Carbohydrate Absorption, Transmembrane Transport and Metabolism.- 40. Disorders of the Pentose Phosphate Pathway and Polyol Metabolism.- 41. Hyperinsulinism.- Part 5. MITOCHONDRIAL DISORDERS OF ENERGY METABOLISM.- 42. Disorders of the Pyruvate Metabolism and the Krebs Cycle.- 43. Disorders of Mitochondrial Carriers.- 44. Isolated Mitochondrial Complex Deficiencies.- 45. Disorders of Replication, Transcription and Translation of Mitochondrial DNA.- 46. Disorders of mitochondrial homeostasis, dynamics, protein import and quality control.- 47. Primary Coenzyme Q10 Deficiencies.- Part 6. DISORDERS OF LIPIDS.- 48. Mitochondrial Fatty Acid Oxidation Disorders.- 49. Disorders of Glycerol Metabolism.- 50. Disorders of Ketone Body Metabolism and Transport.- 51. Disorders of Complex Lipids.- 52. Disorders of Eicosanoid Metabolism.- 53. Disorders of Lipoprotein Metabolism.- 54. Disorders of Cholesterol Biosynthesis.- 55. Disorders of Adrenals and Gonads.- 56. Disorders of Bile Acid Synthesis. Part 7. DISORDERS OF TETRAPYRROLES.- 57. Disorders of Heme Metabolism.- 58. Inherited Disorders of Bilirubin Metabolism.- Part 8. STORAGE DISORDERS.- 59. Disorders of Autophagy.- 60. Lipidoses: The Sphingolipidoses, Lysosomal Acid Lipase Deficiency and Niemann Pick type C.- 61. The Neuronal Ceroid Lipofuscinoses.-62. Mucolipidoses, Multiple Sulfatase deficiency, Cathepsin K and C Deficiency.- 63. Oligosaccharidoses and Sialic Acid Disorders.- 64. The Mucopolysaccharidoses.- 65. Cystinosis.- Part 9. DISORDERS OF PEROXISOMES AND OXALATE.- 66. Peroxisomal Disorders.- 67. Disorders for Oxalate Metabolism.- Part 10. CONGENITAL DISORDERS OF GLYCOSYLATION.- 68. Congenital Disorders of Glycosylation.- Part 11. VARIOUS.- 69. Cerebral Organic Acidurias.- 70. 3-Methylglutaconic acidurias.- 71. Biochemical Phenotypes of Questionable Clinical Significance.- 72. Knowledgebase of Inborn Errors of Metabolism (IEMbase): A Practical Approach.- 73. WikiPathways: Integrating Pathway Knowledge with Clinical Data.
£179.99
Springer Nature Switzerland AG Formulating Poorly Water Soluble Drugs
Book SynopsisThe objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop.Table of ContentsContents 1. Route-Specific Challenges in the Delivery of Poorly Water-Soluble Drugs ……………….. Zachary Warnken, Hugh D.C. Smyth, and Robert O. Williams III 2. Optimizing the Formulation of Poorly Water-Soluble Drugs………………………….. Xiangyu Ma, Daniel Ellenberger, Kevin P. O’Donnell, and Robert O. Williams III 3. Solid-State Techniques for Improving Solubility ……………………………………….. Miguel O. Jara, Justin R. Hughey, Siyuan Huang, and Robert O. Williams III 4. Mechanical Particle-Size Reduction Techniques…………………………..……….…… Javier O. Morales, Alan B. Watts, and Jason T. McConville 5. Co-solvent and Complexation Systems …………………………………………….... Junhuang Jiang and Robert O. Williams III 6. Injectable Formulations of Poorly Water-Soluble Drugs ………………………….…... Hannah L. O’Mary and Zhengrong Cui, 7. Lipid-Based Formulations…………………………………………………................... Daniel A. Davis Jr., Han-Hsuan Peng, and Robert O. Williams III 8. Structured Development Approach for Amorphous Systems ……………………….... Susanne Page, Reto Maurer, Nicole Wyttenbach, and Felix Ditzinger 9. Melt Extrusion………………………………………………………………………. Stephen A. Thompson, Daniel A. Davis Jr., James C. DiNunzio, Charlie Martin, Robert O. Williams III, and Feng Zhang 10. Spray-Drying Technology…………..………..………..………..……………………….. Dave A. Miller, Daniel Ellenberger, Tiago Porfirio, and Marco Gil 11. Pharmaceutical Cryogenic Technologies ………………………………………….... Sawittree Sahakijpijarn, Chaeho Moon, and Robert O. Williams III 12. Precipitation Technologies for Nanoparticle Production ……………………………. Tuangrat Praphawatvet and Robert O. Williams III 13. Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs … Daniel A. Davis Jr., Rishi Thakkar, Mohammed Maniruzzaman, Dave A. Miller, Robert O. Williams III 14. Scientific and Regulatory Considerations for Development and Commercialization of Poorly Water-Soluble Drugs…………………………………………………………………. .Zedong Dong and Hasmukh Patel
£179.99
Springer Nature Switzerland AG Hazardous Environmental Micro-pollutants, Health
Book SynopsisThis volume discusses hazardous environmental micropollutants, their impacts on human health, and possible means to mitigate their associated risks. The book features chapters that cover a variety of topics related to environmental micropollutants, which include dusts, infectious particles, heavy metals, organophosphates, atmospheric toxic organic micropollutants, fungal spores, pollutants from E-waste, antibiotic waste, and more. In addition impacts on human health and the environment, economic issues are addressed, with potential policy solutions offered. This work is timely, as hazardous micropollutants in soil, water and air are becoming more common, and this environmental contamination is leading to increasing instances of suboptimal human health outcomes. The book will be of interest to students and researchers in environmental pollution and remediation technology, microbiologists, and environmental regulators. Table of ContentsChapter 1-Environmental Micropollutants.- Chapter 2-Infectious Diseases, Challenges and their Impacts on Human Health under Changing Climate.- Chapter 3-Marble Dust as an Environmental and Occupational Hazard.- Chapter 4-Impacts of Micropollutants on Economy and Main Spheres of Environment: Soil, Air and Water.- Chapter 5-Micropollutants Impacts and Preventive Measures to Reduce Diseases Burden among School Children.- Chapter 6-Emerging Organic Contaminants, Pharmaceuticals and Personal Care Products (PPCPs): A Threat to Water Quality.- Chapter 7-Environmental and Health Effects of Heavy Metals and their Treatment Methods.- Chapter 8-Organophosphates Pollution Status and their Remediation through Microbial Interaction in 21st Century.- Chapter 9-Atmospheric Toxic Organic Micropollutants.- Chapter 10-Impact of Aerial Fungal Spores on Human Health.- Chapter 11-Health Risks Associated with Arsenic Contamination and its Biotransformation Mechanisms in Environment: A Review.- Chapter 12-E-waste Threaten to Environment and Public Health.- Chapter 13-Manufacturing and use of flame retardant chemicals and their impact on the environment and public health.- Chapter 14-Mycotoxins in Environment and Its Health Implications.- Chapter 15-Antibiotics; Multipronged Threat to Our Environment.- Chapter 16-Microplastic pollution and Their Health Impacts.- Chapter 17-Treatment Technologies for the Environmental Micropollutant.
£98.99
Springer International Publishing AG Inorganic Polyphosphates: From Basic Research to
Book SynopsisThis volume focuses on the biomedical aspects of inorganic polyphosphates, a family of unique bio-inorganic polymers.In recent years, great advances have been made in understanding the development, metabolism, and physiological role of inorganic polyphosphates. These energy-rich polymers, which consist of long chains of phosphate units, are evolutionary old molecules. The acidocalcisomes, conserved organelles from bacteria to humans, as well as the mitochondria play a central role in polyphosphate production and storage. Polyphosphates have been assigned multiple functions, some of which are closely related to medically important processes, such as blood coagulation and fibrinolysis, energy metabolism, cell cycle regulation, apoptosis, chaperon function, microvascularization, stress response, neurodegeneration and aging. The development of bioinspired polyphosphate particles, in combination with suitable hydrogel-forming polymers enabled the development of new strategies in regenerative medicine, in particular for hard and soft tissue repair, but also in drug delivery and antimicrobial defense. This book not only highlights the basic research in this area, but also discusses possible applications. Therefore, it appeals to scientists working in cell biology, biochemistry, and biomedicine and practicioners alike.Table of Contents1. Mitochondrial polyP production Prof. Dr. Andrey Y. Abramov, University College London, London, UKa.abramov@ucl.ac.uk 2. Polyphosphate in thrombosis and inflammation Prof. Dr. James H. Morrissey and Dr. Stephanie Smith, University of Michigan Medical School, Ann Arbor MI, USAjim@tf7.org or jhmorris@umich.edu3. Polyphosphate in mitochondrial energy metabolism and pathologyProf. Dr. Evgeny Pavlov, NYU College of Dentistry, New York NY, USAep37@nyu.edu4. Polyphosphate in plasma and human pathologies Prof. Dr. Felix Ruiz, Facultad de Medicina, Universidad de Cádiz, Cádiz, Spainfelix.ruiz@uca.es5. PolyP in neurodegeneration and agingProf. Dr. Maria E. Solesio, Rutgers University, Camden NJ, USAm.solesio@rutgers.edu6. Effects of polyphosphate on function of leukocytesDr. Patrick Suess, University of Michigan Medical School, Ann Arbor MI, USApsuess@med.umich.edu7. PolyP and Vtc complexProf. Dr. Andreas Mayer, University of Lausanne, Epalinges, Switzerlandandreas.mayer@unil.ch8. PolyP in antiviral protectionProf. Dr. Dr. h.c. Werner E. G. Müller, Prof. Dr. Xiaohong Wang, Prof. Dr. Dr. Heinz C. Schröder, University Medical Center of Johannes Gutenberg University Mainzwmueller@uni-mainz.de9. Polyphosphate in biomimetic implant materialsProf. Dr. Dr. Heinz C. Schröder, Prof. Dr. Xiaohong Wang, Prof. Dr. Dr. h.c. Werner E. G. Müller, University Medical Center of Johannes Gutenberg University Mainzwmueller@uni-mainz.de
£98.99
Springer International Publishing AG Drugs Easily Explained
Book SynopsisBillions of people worldwide take medicines every day to treat important diseases. In many cases, however, neither the doctor nor the pharmacist has the time to explain to the patient why a particular drug should be taken, how the drug works and what side effects to expect. Of course, the patient can find "everything" about a particular drug on the Internet. But how reliable and understandable is this information? In addition, most Internet sources do not point out the interrelationships between different diseases and drug interactions. Written by an experienced and well-known textbook author, this book provides an overview of the most common diseases and the drugs used to treat them. The book is designed for a general audience. It provides patients with essential information about how medications work and what side effects and interactions to expect. Finally, the book gives patients advice on what they can do themselves to improve drug therapy and safety. Summaries, bullet points, tables and diagrams support the information process.Table of ContentsChapter 1. What Should I Know About Drugs?.- Chapter 2. Painkillers (analgesics).- Chapter 3. Drugs for Gastrointestinal Disorders.- Chapter 4. Drugs for Respiratory Diseases.- Chapter 5. Drugs for Cardiovascular Diseases.- Chapter 6. Drugs for Metabolic Disorders.- Chapter 7. Drugs for Her and Him.- Chapter 8. Drugs for Neurological Disorders.- Chapter 9. Drugs for Mental Disorders.- Chapter 10. Drugs for Eye Diseases.- Chapter 11. Drugs for Cancer and Autoimmune and Infectious Diseases.
£18.74
Springer International Publishing AG Principles and Practices of Lyophilization in
Book SynopsisThe biotechnology/biopharmaceutical sector has tremendously grown which led to the invention of engineered antibodies such as Antibody Drug Conjugates (ADCs), Bispecific T cell engager ( BITES), Dual Variable Domain ( DVD), Chimeric Antigen Receptor - Modified Tcells (CART) that are currently being used as therapeutic agents for immunology and oncology disease conditions. In addition to other pharmaceuticals and biopharmaceuticals, all these novel formats are fragile with respect to their stability/structure under processing conditions meaning marginal stability in the liquid state and often require lyophilization to enhance their stability and shelf-life. This book contains chapters/topics that will describe every aspect of the lyophilization process and product development and manufacturing starting from the overview of lyophilization process, equipment required, characterization of the material, design and development of the formulation and lyophilization process, various techniques for characterization of the product, scale-up/tech-transfer and validation. It also describes the application of CFD coupled with mathematical modeling in the lyophilization process and product development, scale-up, and manufacturing. Additionally, Principles and Practice of Lyophilization Process and Product Development contains an entire dedicated section on “Preservation of Biologicals” comprised of nine chapters written by experts and including case studies.Table of Contents1. Overview of Freeze Drying2. Characterization and Determination of Freeze Drying Properties of Frozen Formulations- Case Studies3. Beyond pH: Acid/base relationships in frozen and freeze-dried pharmaceuticals4. Concepts and Strategies in the Design of Formulation for Freeze Drying5. Formulation Design for Freeze Drying - Case studies of Stabilization of Proteins6. Challenges and Considerations in the Development of a High Protein Concentration Lyophilized Drug Product7. Freeze-drying of thermosensible pharmaceuticals with organic co-solvent + water formulations8. Primary container closure system selection for lyophilized drug products9. Vial Breakage During Lyophilization10. The Nucleation of Ice11. Stresses, Stabilization, and Recent Insights in Freezing of Biologics12. Lyophilization Process Understanding and Scale-up using ab initio Vial Heat Transfer Modeling13. Secondary drying: Challenges and Considerations14. Design and Process Considerations in Spray Freeze Drying15. LyoPRONTO: Deterministic and Probabilistic Modeling. Tutorial and Case Study16. Utilizing Solid-State NMR Spectroscopy to Assess Properties of Lyophilized Formulations17. Design of Moisture Studies for a Lyophilized Product18. Laser-Based Headspace Moisture Analysis for Rapid Nondestructive Moisture Determination of Lyophilized Products19. Application of PAT in Real-time Monitoring and Controlling of Lyophilization Process20. Process Analytical Technology (PAT) for Lyophilization Process Monitoring and End Point Detection21. Advances in Process Analytical Technology – A Small Scale Freeze-Dryer for Process Analysis, Optimization, and Transfer Advances in Process Analytical Technology – A Small Scale Freeze-Dryer for Process Analysis, Optimization, and Transfer22. Overview of Heat and Mass Transfer Modeling in Lyophilization to Create Design Spaces and Improve Process Analytical Tool (PAT) Capability23. Application of QbD elements in the Development and Manufacturing of a Lyophilized product.- Characterization of Freeze Dryer24. Characterization of Freeze Dryer25. Scale-up and Technology Transfer of a Lyophilization Process26. Lyophilization Validation: Process Design and Modeling27. Lyophilization Validation: Process Qualification and Continued Process Verification28. Homogeneity Assessment of Lyohilized Biological Drug Products During Process Performance Qualification29. Informed Manufacturing through the use of Big Data Analytics for Freeze Drying Process & Equipment30. Multivariate Analysis for Process Understanding, Continuous Process Verification and Condition Monitoring of Lyophilization Processes31. Lyophilized Drug Product Cake Appearance: What Is Acceptable?
£125.99
Springer International Publishing AG Plant Molecular Farming: Applications and New
Book SynopsisMolecular farming is a biotechnological approach that includes the genetic adjustment of agricultural products to create proteins and chemicals for profitable and pharmaceutical purposes. Plant molecular farming describes the manufacture of recombinant proteins and other biologically active product in plants. This approach depends on a genetic transformation of plants that can be accomplished by the methods of stable gene transfer, such as gene transfer to nuclei and chloroplasts, and unstable transfer methods like viral vectors. The requirement for recombinant proteins in terms of quality, quantity, and diversity is increasing exponentially This demand is traditionally met by recombinant protein construction technologies and the engineering of orthodox expression systems based on bacteria or mammalian cell cultures. However, majority of developing countries cannot afford the high costs of medicine derived from such existing methods. Hence, we need to produce not only the new drugs but also the cheaper versions of those already present in the market. Plant molecular farming is considered as a cost-effective technology that has grown and advanced tremendously over the past two decades. This book summarizes the advances and challenges of plant molecular farming for all those who are working on or have an interest in this rapidly emerging area of research.Table of ContentsChapter. 1. Molecular Farming in Plants: Introduction and ApplicationsChapter. 2. Tools and Techniques Used in Plant Molecular FarmingChapter. 3. Production of plant natural products in heterologous microbial speciesChapter. 4. Sustainable Manufacturing of Vaccines, Antibodies, and other PharmaceuticalsChapter. 5. Limitations, Biosafety, ethics, regulatory issues in molecular farming in plantsChapter. 6. Conclusion and Perspectives
£37.99
Springer International Publishing AG Nanozymes in Medicine
Book SynopsisThis book reviews the latest advances and biomedical applications of nanozymes, which are artificial nanomaterials exhibiting enzymatic properties similar to natural enzymes, but with less limitations than natural enzymes. Nanozymes display advantages such as facile synthesis, easy surface modification, improved stability, higher catalytic power, and target-specific binding. Nanozymes containing metals, metal oxides, carbon, and metal sulfide are actually used for cancer therapy, biomolecules sensing, bioimaging, disease diagnostics and diabetes management. The book discloses underlying mechanisms, concepts, recent trends, constraints, and prospects for nanomedicine using nanozymes.Table of Contents1. Nano cerium oxide in medicine, agriculture and the industry2. Synthesis and sensing applications of peroxidase-mimic nanozyme3. Nanozymes for glucose sensing and diabetes management4. Nanozymes for bioimaging and disease diagnostics5. Nanozymes for improving anticancer therapy6. Enzyme-based nanomedicine for cancer therapy7. Synthesis of two-dimensional metal, metal oxide and metal hydroxide nanomaterials for biosensing8. Biological applications of nanozymes
£125.99
Springer International Publishing AG Nanozymes in Medicine
Book SynopsisThis book reviews the latest advances and biomedical applications of nanozymes, which are artificial nanomaterials exhibiting enzymatic properties similar to natural enzymes, but with less limitations than natural enzymes. Nanozymes display advantages such as facile synthesis, easy surface modification, improved stability, higher catalytic power, and target-specific binding. Nanozymes containing metals, metal oxides, carbon, and metal sulfide are actually used for cancer therapy, biomolecules sensing, bioimaging, disease diagnostics and diabetes management. The book discloses underlying mechanisms, concepts, recent trends, constraints, and prospects for nanomedicine using nanozymes.Table of Contents1. Nano cerium oxide in medicine, agriculture and the industry2. Synthesis and sensing applications of peroxidase-mimic nanozyme3. Nanozymes for glucose sensing and diabetes management4. Nanozymes for bioimaging and disease diagnostics5. Nanozymes for improving anticancer therapy6. Enzyme-based nanomedicine for cancer therapy7. Synthesis of two-dimensional metal, metal oxide and metal hydroxide nanomaterials for biosensing8. Biological applications of nanozymes
£125.99
Springer International Publishing AG Pharmaceutical Applications of Supramolecules
Book SynopsisThis book outlines the use of supramolecules as different pharmaceutical drugs. Supramolecular chemistry in pharmaceutical sciences is quite a young and rapidly developing field. Supramolecular assemblies might offer an alternative for existing pharmaceutical formulations, as they facilitate the improvement of physicochemical and pharmacological properties i.e., higher bioavailability, better biocompatibility and drug-targeting, fewer multidrug-resistances. This book offers an overview of the recent advances in supramolecular structures and discusses the future aspects and challenges related to the development of these molecules, providing also a perspective on how to overcome these issues. Divided into 13 chapters contributed by experts in their field, the book provides a deeper understanding of intermolecular forces playing pivotal roles in mediating the interactions between chemical molecules and biological systems by focusing on different applications of supramolecular compounds. In this book, readers will find valuable insights into the preparation of supramolecules and the latest research and development trends of supramolecules as anticancer drugs, including liquid-crystalline supramolecular assemblies, and as antimicrobial, antiviral, anti-inflammatory and cardiovascular drugs. Particular attention is given to the application of supramolecules in the fields of biomedicine, bioimaging, and vaccine development. Given its breadth, this book will appeal to a wide readership from researchers and students interested in these fields to professionals in the pharma industry.Table of ContentsTable of Contents (13 Chapters)1. Supramolecules in pharmaceutical science: A brief overviewNidhi Goel* and Naresh Kumar*2. Basic strategy and methods of preparation for supramoleculesVikrant Jayant, Shakeel Alvi and Rashid Ali*3. Research and development of supramolecules as anticancer drugsManjit and Brahmeshwar Mishra*4. Research and development of liquid-crystalline supramolecular assemblies as anticancer drugsAtsushi Yoshizawa*5. Progressive approach of supramolecules towards the advancement of antimicrobial drugsManju Sharma, Nidhi Aggarwal, Sonika Chibh, Avneet Kour, Samraggi Choudhury and Jiban Jyoti Panda*6. Promising functional supramolecules in antiviral drugsKanika Arora, Aakriti Singh, Aaqib Javaid and Shyam lal Mudavath*7. Role of supramolecules in anti-inflammatory drugsPatil Shivprasad Suresh, Anmol and Upendra Sharma*8. Recent advancements of supramolecules in the evolution of cardiovascular drugsMerve Kiremit and Ayse B. Tekinay*9. Development of supramolecules in the field of nanomedicinesAbhishesh Kumar Mehata and M. S. Muthu*10. Supramolecular self-assembled peptide-based nanostructures and their applications in biomedicineUttam Ghosh and Goutam Ghosh*11. Recent advancement of supramolecules in the field of bioimagingUttam Ghosh , Naresh Kumar and Goutam Ghosh*12. Role of supramolecules in vaccine developmentNaresh Kumar* and Nidhi Goel*13. Supramolecules: Future challenges and perspectivesNidhi Goel* and Naresh Kumar*
£132.99
Springer International Publishing AG Biochemistry and Cell Biology of Ageing: Part IV,
Book SynopsisThis book provides an up-to-date overview of key areas of ageing research and bridges the gap between the subcellular events and the reality of ageing as seen in clinical practice.To this end, the reader learns about the historical development and progression of clinical ageing research. All chapters address the biochemistry or cell biology of various ageing events (to the extent that the data are available) and work their way to the clinical understanding we have of ageing. The focus of this volume is on how dietary restriction, virus infection and chronic inflammation affect the ageing process. Additionally, this book discusses how phosphate metabolism and metabolic dysfunction contribute to ageing events and how various organs and tissues (e.g. tendons, ears, heart muscle, and the endocrine system) age. This book follows on from Parts I, II and III of Biochemistry and Cell Biology of Ageing within the Subcellular Biochemistry book series and aims to bring the subcellular and clinical areas into closer contact by including interesting and significant biomedical ageing topics that were not included in the earlier volumes. Comprehensive and cutting-edge, this book is a valuable resource for experienced researchers and early career scientist alike, who are interested in learning more about the fascinating and challenging question of why and how our cells age.Table of ContentsSee Attachments
£134.99
Springer International Publishing AG Pharmaceutical Biotechnology: Fundamentals and
Book SynopsisThis introductory text explains both the basic science, production, quality, dosage forms, administration, economic and regulatory aspects and the clinical applications of biotechnology-derived pharmaceuticals. It serves as a complete one-stop source for undergraduate/graduate pharmacists and pharmaceutical science students. An additional important audience are pharmaceutical scientists in industry and academia, particularly those who have not received formal training in pharmaceutical biotechnology and are inexperienced in this field. The rapid growth and advances in the field made it necessary to revise this textbook in order to continue providing up-to-date information and introduce readers to cutting edge knowledge and technology of this field. This Sixth Edition completely updates the previous edition and includes additional coverage on new approaches such as oligonucleotides, siRNA, mRNA, gene therapy, cell therapies, monoclonal antibodies and vaccines. With more than 3-million-chapter downloads, the fifth edition of the textbook has achieved widespread distribution as a key educational resource for the field of pharmaceutical biotechnology. Table of ContentsMolecular Biotechnology.- Biophysical and biochemical analysis of recombinant proteins.- Production and downstream processing of biotech products.- Formulation of biotech products, including biopharmaceutical considerations.- Pharmacokinetics and pharmacodynamics of peptide and protein drugs.- Immunogenicity of pharmaceutical proteins.- General considerations of monoclonal antibodies from structure to therapeutic application.- Genomics, Other “Omics” Technologies, Personalized Medicine and Additional Biotechnology-Related Techniques.- Dispensing biotechnology products: handling, professional education and product information.- Economic considerations in medical biotechnology.- Regulatory framework for biosimilars.- Vaccines.- Oligonucleotides and siRNA.- Gene therapy.- Stem cell technology.- Therapeutic Applications.-Endocrinology.- Insulin.- Follicle-stimulating hormone.- Growth hormone.- Cardiovascular and Respiratory Applications.- Recombinant coagulation factors and thrombolytics.- Recombinant human deoxyribonuclease.- Oncology.- Monoclonal antibodies in oncology .- Hematopoetic growth factors.- Inflammation and Immunemodulation.- Monoclonal antibodies in transplantation.- Monoclonal antibodies and antibody-based therapeutics in anti-inflammatory therapy.- Interferons and interleukins.- Anti-infectious diseases.- Monoclonal antibodies.- Enzyme replacement therapy.
£67.49
De Gruyter Drug Repurposing
Book SynopsisDrug repurposing, or drug repositioning, or reprofiling, has emerged as a valid approach in modern drug discovery. The book describes tools and techniques for identifying new therapeutic potentials for existing drugs and covers the repurposing of drugs from synthetic and natural origin. It compares the costs of drug repurposing with traditional drug discovery and discusses challenges and future perspectives of drug repurposing.
£63.65
De Gruyter Phytochemicals in Medicinal Plants: Biodiversity, Bioactivity and Drug Discovery
Book SynopsisBenefitting from phytochemicals in medicinal plants has lately gained increasingly more global relevance. The medicinal bioactivity might range from wound healing activity to anti-inflammatory and anti-viral effects. This work describes the challenging scientific process of systematic identification and taxonomy through molecular profiling and nanoparticle production from plant extracts until a final use for e.g. cancer or HIV treatment. From the table of contentsPART A: Biodiversity & Traditional Knowledge.__Habitats and Distribution.__Threats and Conservation.__Culture, tradition and indigenous practices.PART B: Phytochemical constituents – Molecules and Characterization Techniques.__Alkaloids & Flavonoids.__Tannin, Saponnin and Taxol.__Terpenoids, Steroids and Phenolic Compounds.__Essential oil and their constituents.__Characterization Techniques used for the analysis of phytochemical constituents.PART C: Medicinal Bioactivity.__Anti-cancerous and Anti HIV activity.__Anti-microbial, Anti-inflammatory and wound healing activity.__Anti-oxidant activity.__Anti-diabetic activity.__Anti-Corona virus and anti-viral activity.PART D: Nanotechnology.__Nano-materials synthesis from medicinal plant extract.__Characterization and activity of medicinal plant based nanoparticles.PART E: Pharmacology/Drug discovery.__Plant phytochemicals in drug discovery.__Extraction and production of drugs.__System pharmacology and drug discovery.
£85.95
