Medicinal chemistry Books
Penguin Books Ltd Periodic Tales
Book SynopsisTHE PHENOMENAL SUNDAY TIMES BESTSELLER ''Science writing at its best. If only chemistry had been like this at school'' Matt Ridley ____________________ Everything in the universe is made of them, including you. Like you, the elements have personalities, attitudes, talents, shortcomings, stories rich with meaning. Here you''ll meet iron that rains from the heavens and noble gases that light the way to vice. You''ll learn how lead can tell your future while zinc may one day line your coffin. You''ll discover what connects the bones in your body with the Whitehouse in Washington, the glow of a streetlamp with the salt on your dinner table. Unlocking their astonishing secrets and colourful pasts, Periodic Tales is a voyage of wonder and discovery, showing that their stories are inextricable from the stories of our own lives. ____________________ ''A love letter to the chemical elements. Aldersey-Williams is full of good stories and he knows how to tell them well'' Sunday Telegraph ''The history, science, art, literature and everyday applications of all the elements from aluminium to zinc'' The Times ''Great fun to read and an endless fund of unlikely and improbable anecdotes'' Financial TimesTrade ReviewScience writing at its best ... fascinating and beautiful ... if only chemistry had been like this at school ... to meander through the periodic table with him ... is like going round a zoo with Gerald Durrell ... a rich compilation of delicious tales, but it offers greater rewards, too -- Matt RidleyImmensely engaging and continually makes one sit up in surprise * Sunday Times *Splendid ... enjoyable and polished * Observer *Full of good stories and he knows how to tell them well ... an agreeable jumble of anecdote, reflection and information * Sunday Telegraph *Great fun to read and an endless fund of unlikely and improbable anecdotes ... sharp and often witty * Financial Times *A joyous romp through the chemical elements * Today, BBC Radio 4 *Not only a cultural history of the elements, it is also a lament to the loss of science as a hobby * Economist *A flashily brainy book, crammed with literary references and held together by a personal quest to collect as many elements as possible * Telegraph *'Elements are fun' is the essential premise of Hugh Aldersey-Williams's new book and by heck he's right ... Aldersey-Williams mourns the fact chemistry isn't really sexy any more; Periodic Tales is a step towards it getting its mojo back * Metro **** *Imaginative and fun ... almost every page yields a nugget * Nature *
£12.34
Oxford University Press An Introduction to Medicinal Chemistry
Book SynopsisThe market-leader in medicinal chemistry: clear, supportive, and practical. It helps students to effortlessly make the link from theory to real-life applications using practical and focused coverage alongside a package of supportive online resources.Trade ReviewThe best general undergraduate textbook on medicinal chemistry. This new edition retains the accessible style of writing, but provides important updates on the topics. * Dr Mark Ashton, School of Pharmacy, Newcastle University, UK *I read this masterpiece to build a strong knowledge of medicinal chemistry and it has helped me a lot. I would definitely recommend it to others. Detailed explanations of enzyme-substrate interactions and much more are very useful. * Jinkal Gondaria, MChem student, Manchester Metropolitan University, UK *A very useful medical chemistry book and teaching tool. Great learning resources and easy to digest content. * Dr Silvia M.M.A. Pereira-Lima, Department of Chemistry, University of Minho, Portugal *Table of Contents1: Drugs and Drug Targets 2: Protein Structure and Function 3: Enzymes: Structure and Function 4: Receptors: Structure and Function 5: Receptors and Signal Transduction 6: Nucleic Acids: Structure and Function 7: Enzymes as Drug Targets 8: Receptors as Drug Targets 9: Nucleic Acids as Drug Targets 10: Miscellaneous Drug Targets 11: Pharmacokinetics and Related Topics Case Study 1: Statins 12: Drug Discovery: Finding a Lead 13: Drug Design: Optimizing Target Interactions 14: Drug Design: Optimizing Access to the Target 15: Getting the Drug to Market Case Study 2: The Design of ACE Inhibitors Case Study 3: Artemisinin and Related Antimalarial Drugs Case Study 4: The Design of Oxamni Case Study 5: Fosfidomycin as an Antimalarial Agent 16: Combinatorial and Parallel Synthesis 17: In Silico Drug Design 18: Quantitative Structure-Activity Relationships Case Study 6: De Novo Design of a Thymidylate Synthase Inhibitor 19: Antibacterial Agents 20: Antiviral Agents 21: Anticancer Agents 22: Protein Kinase Inhibitors as Anticancer Agents 23: Antibodies and Other Biologics 24: Cholinergics, Anticholinergics, and Anticholinestarases 25: Drugs Acting on the Adrenergic Nervous System 26: The Opioid Analgesics 27: Anti-Ulcer Agents 28: Cardiovascular Drugs Case Study 7: Steroidal Anti-Inflammatory Agents Case Study 8: Design of a Novel Antidepressant Case Study 9: The Design and Development Of Aliskiren Case Study 10: Factor Xa Inhibitors Case Study 11: Reversible Inhibitors of HCV NS-34A Protease
£52.99
John Wiley & Sons Inc Disaster Response and Recovery
Book SynopsisTable of ContentsAbout the Author xvii Foreword xix Preface xxi Acknowledgments xxv About the Companion Website xxvi 1 Knowing What to Expect: Hazards, Vulnerability, and Disasters 1 2 Understanding the Actors: Roles and Responsibilities of Relevant Stakeholders 53 3 Anticipating Attitudes and Behavior in Disasters: Myths, Exaggerations, and Realities 93 4 Applying Alternative Management Approaches: Disaster Response and Recovery Theory 123 5 Implementing Initial Response Measures: Hazard Detection, Warning, Evacuation and Sheltering 149 6 Caring For the Injured, Dead, and Distraught: Overcoming Physical and Emotional Impacts 191 7 Managing Public Information, Donations, and Volunteers: Expected Difficulties and Benefits 237 8 Moving Beyond Immediate Needs: Damage Assessment, Disaster Declarations, and Debris Removal 277 9 Promoting Recovery and Mitigation: Disaster Assistance, Rebuilding, and Vulnerability Reduction 317 10 Overcoming Typical Challenges: Vital Considerations for Response and Recovery 357 11 Harnessing Technology and Organization: Tools and Structures for Effective Operations 407 12 Foreseeing the Future: Prior Lessons, Unaddressed Risks, and Rising Vulnerability 455 13 Enhancing Disaster Resilience: Preparedness, Improvisation, Spontaneous Planning, Leadership, and Professionalism 517 Index 559
£70.25
Headline Publishing Group Cannabis is Medicine
Book SynopsisIn Cannabis Is Medicine, medical cannabis specialist Bonni Goldstein, MD, explains the science behind the use of this amazingly therapeutic plant and describes in easy-to-understand detail the recently discovered endocannabinoid system, involved in almost every human physiological process. Over 4 million people in the US are healing difficult-to-treat illnesses with cannabis medicine, and although 33 states have medical cannabis laws, many physicians remain reluctant to discuss how this plant may be beneficial to health. this book is the comprehensive resource for patients and their loved ones who have not found answers with conventional medicines.Dr Goldstein has helped thousands of suffering patients -- including children -- find relief with cannabis. In her revelatory book, she explains the current state of scientific research on more than 28 chronic medical conditions that have responded positively to treatment with cannabis, and offers actionable adTrade ReviewDr. Goldstein sets the record straight on cannabis, offering an in-depth, scientific look at the potent healing power of this much-maligned plant. Anyone considering cannabis medicine for themselves or a loved one needs to read this book. * Mark Hyman, MD, author of Food: What the Heck Should I Eat? *Cannabis Is Medicine tells it like it is. For far too long the important medicinal potential of the cannabis plant has been at least overlooked, and at worst, aggressively stigmatized. The incredible potential of cannabis derivatives across a wide panorama of medical conditions is now widely embraced by highly respected science. And Dr. Bonni Goldstein has done a magnificent job of eloquently presenting this science to augment our tools as healthcare providers as well as for consumers at large. A powerful validation of the healing properties of cannabis. * David Perlmutter, MD, bestselling author of Grain Brain and Brain Wash *
£15.29
Springer-Verlag New York Inc. Advanced Organic Chemistry
Book SynopsisAlkylation of Enolates and Other Carbon Nucleophiles.- Reactions of Carbon Nucleophiles with Carbonyl Compounds.- Functional Group Interconversion by Substitution, Including Protection and Deprotection.- Electrophilic Additions to Carbon-Carbon Multiple Bonds.- Reduction of Carbon-Carbon Multiple Bonds, Carbonyl Groups, and Other Functional Groups.- Concerted Cycloadditions, Unimolecular Rearrangements, and Thermal Eliminations.- Organometallic Compounds of Group I and II Metals.- Reactions Involving Transition Metals.- Carbon-Carbon Bond-Forming Reactions of Compounds of Boron, Silicon, and Tin.- Reactions Involving Carbocations, Carbenes, and Radicals as Reactive Intermediates.- Aromatic Substitution Reactions.- Oxidations.- Multistep Syntheses.Trade ReviewFrom the reviews of the fifth edition: "Advanced Organic Chemistry … the well-known textbook for graduate students – has now appeared in a 5th edition. … Carey & Sundberg will be interesting to all students who seek a detailed understanding of organic chemistry, and who wish to refresh and embellish their existing knowledge. On the strength of the scope and quality of the explanations, this pair of texts is recommended for use as the resource of first resort for specific research questions in one’s later career." (www.organische-chemie.ch, January, 2008)Table of ContentsAlkylation of Enolates and Other Carbon Nucleophiles.- Reactions of Carbon Nucleophiles with Carbonyl Compounds.- Functional Group Interconversion by Substitution, Including Protection and Deprotection.- Electrophilic Additions to Carbon-Carbon Multiple Bonds.- Reduction of Carbon-Carbon Multiple Bonds, Carbonyl Groups, and Other Functional Groups.- Concerted Cycloadditions, Unimolecular Rearrangements, and Thermal Eliminations.- Organometallic Compounds of Group I and II Metals.- Reactions Involving Transition Metals.- Carbon-Carbon Bond-Forming Reactions of Compounds of Boron, Silicon, and Tin.- Reactions Involving Carbocations, Carbenes, and Radicals as Reactive Intermediates.- Aromatic Substitution Reactions.- Oxidations.- Multistep Syntheses.
£49.49
Taylor & Francis Ltd Aromatic and Medicinal Plants of Drylands and
Book SynopsisThe description and analysis of the Mexican and other countries desertic plants from the point of view of their use in traditional medicine and their potential use in integrative medicine is the overall theme of this book. Aromatic and Medicinal Plants of Drylands and Deserts: Ecology, Ethnobiology and Potential Uses describes the historic use of drylands plants, botanical and geological classification, also describes the endemic plants used in traditional medicine, going through the most relevant aspects of biomedicine and integrative medicine. The chemical and bioactive compounds from desertic medicinal and aromatic plants and the analytic techniques to determine chemical and bioactive compounds from the medicinal and aromatic plants are reviewed. Ethnobiology is detailed in the present book as well as the importance of the integrative medicine for the ancient and actual cultures. The book represents an effort to keep the ethnobiological knowledge of communities for the use of traTable of ContentsPrefaceChapter 1 Introduction to plant taxonomy: vascular and non-vascular plants with medicinal use. Muro-Pérez G., Sánchez-Salas J., Cano-Villegas O., López-García R., Valenzuela-Núñez L. M.Chapter 2 Mexican desertic medicinal plants: biology, ecology, and distribution. Hernández-Herrera J. A., Valenzuela-Núñez L. M., Encina-Domínguez J. A., Martínez-Sifuentes A. R., Lara-Reimers E. A., Navarrete-Molina C.Chapter 3 Mexican Desert: Health and biotechnological properties potential of some cacti species (Cactaceae). Trujillo J., Pérez-Miranda S., Ramírez-Hernández A., Muñiz-Ramírez A., García-Campoy A.H., Ramírez-Rodríguez Y. Chapter 4 Potential of plants from the arid zone of Coahuila in Mexico for the extraction of essential oils. Solís-Quiroz O. S., González-Machado A. C., Aguirre-Joya J. A., Aguillón-Gutiérrez D. R., Ramírez-Moreno A., Torres-León C.Chapter 5 Ethnopharmacology of important Aromatic Medicinal plants of the Caatinga, Northeastern Brazil. Olaitan-Balogun S., Medeiros-Bandeira M. A., do Nascimento-Magalhães K., Lima-Soares I. Chapter 6 Plants of the Chihuahuan Semi-desert for the Control of Phytopathogens. Cándido-del Toro C. A., Arredondo-Valdés R., Govea-Salas M., Anguiano-Cabello J. C., Segura-Ceniceros E. P., Ramos-González R., Ascacio-Valdés J. A., Laredo Alcalá E. I., Iliná A.Chapter 7 Phytochemical compounds from desert plants to management of plant-parasitic nematodes. Marco Tucuch-Pérez A., Arredondo-Valdés R., Hernández-Castillo F. D., Ochoa-Fuentes Y. M., Laredo Alcalá E. I., Anguiano-Cabello J. C.Chapter 8 Plant phytochemicals from the Chihuahuan semi-desert with possible herbicidal actions. Barroso-Ake A. C., Arredondo-Valdés R., Ramos-González R., Laredo-Alcalá E. I., Aguilar-González C. N., Ascacio-Valdés J. A., Govea-Salas M., Iliná A., Tucuh-Peréz M. A.Chapter 9 ¬Chemical and bioactive compounds from Mexican desertic medicinal plants. López-Romero J. C., Torres-Moreno H., Ireta-Paredes A. R., Charles-Rodríguez A. V., Flores-López M. L.Chapter 10 Edible coating based on chia (Salvia hispanica L.) functionalized with Rhus microphylla fruit extract to improve the cucumber (Cucumis sativus L.) shelf life. Charles-Rodríguez AV., Reyes-de la Luz M., Guía-García J. L., Peña-Ramos F.M., Robledo-Olivo A., Hench-Cabrera A. F., Flores-López M. L.Chapter 11 Larrea tridentata: bioactive compounds, biological activities and its potential use in phytopharmaceuticals improvement. López-Romero J. C., Torres-Moreno H, Rodríguez-Martínez K. L., Suárez-García A. del C., Beltrán-Martínez M. E., García-Dávila J.Chapter 12 Toxicological aspects of medicinal plants that growth in drylands and polluted environments. Pérez-Morales R., Téllez López M. A., Olivas Calderón E. H., González-Zamora A.
£147.25
Hodder & Stoughton Dopeworld: Adventures in Drug Lands
Book SynopsisWelcome to Dopeworld. Ecstasy in London, crack in Los Angeles, LSD in Tokyo, heroin in Sofia, cocaine in Medellin, bounty hunting in Manilla, opium in Tehran. Get ready for your next fix. __________Dopeworld is a bold and intoxicating journey into the world of drugs. From the cocaine farms in South America to the streets of Manila, we trace the emergence of psychoactive substances and our intimate relationship with them. With unparalleled access to drug lords, cartel leaders, street dealers and government officials, Niko Vorobyov attempts to shine a light on the dark underbelly drug world.At once a bold piece of reportage and a hugely entertaining and perverse travelogue, Dopeworld reveals how drug use is at the heart of our history, our lives, and our world.__________ With echoes of Gomorrah and Fear and Loathing in Last Vegas, Dopeworld is a brilliant and enlightening journey across the world, examining every angle of the drug war.
£10.44
Springer International Publishing AG Pharmaceutical Biotechnology: Fundamentals and
Book SynopsisThis introductory text explains both the basic science, production, quality, dosage forms, administration, economic and regulatory aspects and the clinical applications of biotechnology-derived pharmaceuticals. It serves as a complete one-stop source for undergraduate/graduate pharmacists and pharmaceutical science students. An additional important audience are pharmaceutical scientists in industry and academia, particularly those who have not received formal training in pharmaceutical biotechnology and are inexperienced in this field. The rapid growth and advances in the field made it necessary to revise this textbook in order to continue providing up-to-date information and introduce readers to cutting edge knowledge and technology of this field. This Sixth Edition completely updates the previous edition and includes additional coverage on new approaches such as oligonucleotides, siRNA, mRNA, gene therapy, cell therapies, monoclonal antibodies and vaccines. With more than 3-million-chapter downloads, the fifth edition of the textbook has achieved widespread distribution as a key educational resource for the field of pharmaceutical biotechnology. Table of ContentsMolecular Biotechnology.- Biophysical and biochemical analysis of recombinant proteins.- Production and downstream processing of biotech products.- Formulation of biotech products, including biopharmaceutical considerations.- Pharmacokinetics and pharmacodynamics of peptide and protein drugs.- Immunogenicity of pharmaceutical proteins.- General considerations of monoclonal antibodies from structure to therapeutic application.- Genomics, Other “Omics” Technologies, Personalized Medicine and Additional Biotechnology-Related Techniques.- Dispensing biotechnology products: handling, professional education and product information.- Economic considerations in medical biotechnology.- Regulatory framework for biosimilars.- Vaccines.- Oligonucleotides and siRNA.- Gene therapy.- Stem cell technology.- Therapeutic Applications.-Endocrinology.- Insulin.- Follicle-stimulating hormone.- Growth hormone.- Cardiovascular and Respiratory Applications.- Recombinant coagulation factors and thrombolytics.- Recombinant human deoxyribonuclease.- Oncology.- Monoclonal antibodies in oncology .- Hematopoetic growth factors.- Inflammation and Immunemodulation.- Monoclonal antibodies in transplantation.- Monoclonal antibodies and antibody-based therapeutics in anti-inflammatory therapy.- Interferons and interleukins.- Anti-infectious diseases.- Monoclonal antibodies.- Enzyme replacement therapy.
£67.49
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Chemical Biology: and Drug Discovery
Book SynopsisThe focus of this textbook is on application, rather than pure knowledge transfer of the results of all chemical biological work (which would also be beyond the scope of a book). It gives the reader, through the specific selection of chemical biological techniques and concepts, the necessary tools to be able to develop new ways of thinking and thus new therapeutic options in the complex field of chemical biology and drug development. The stated aim of this book is to provide concrete solutions and inspiration to students, (post)graduate students, and experienced scientists at universities as well as in industry in their problems. After an introduction to the problems addressed by chemical biology in drug discovery, the three levels of molecular biology dogma: DNA, RNA and proteins and their role as drug targets serve as the common thread of this book.This book is a translation of the original German 1st edition Chemische Biologie by Marco F. Schmidt, published by Springer-Verlag GmbH Germany, part of Springer Nature in 2020. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors.Table of ContentsForeword.- Introduction.- Part I: Chemical Biology and Drug Development.- Chemical Biology - a Holistic Science.- Drug Development.- From Genomics to Chemical Biology.- Part II: DNA.- DNA - blueprint of proteins.- Genomic Variation.- Gene Therapy and Genome Editing.- Part III: RNA.- RNA - information and function carrier.- RNA Interference in Drug Development.- Part IV: Proteins.- Peptides & proteins.- Proteins as drug targets.- Chemical genomics - From target protein to drug.- From target protein to macromolecular drug - Biologics.- Chemical proteomics: From drug to target protein.- Chemical genetics: validation of drug target by elucidation of signaling pathway.- Chemical biology - Addressing new drug targets.
£52.24
Springer International Publishing AG Drugs Easily Explained
Book SynopsisBillions of people worldwide take medicines every day to treat important diseases. In many cases, however, neither the doctor nor the pharmacist has the time to explain to the patient why a particular drug should be taken, how the drug works and what side effects to expect. Of course, the patient can find "everything" about a particular drug on the Internet. But how reliable and understandable is this information? In addition, most Internet sources do not point out the interrelationships between different diseases and drug interactions. Written by an experienced and well-known textbook author, this book provides an overview of the most common diseases and the drugs used to treat them. The book is designed for a general audience. It provides patients with essential information about how medications work and what side effects and interactions to expect. Finally, the book gives patients advice on what they can do themselves to improve drug therapy and safety. Summaries, bullet points, tables and diagrams support the information process.Table of ContentsChapter 1. What Should I Know About Drugs?.- Chapter 2. Painkillers (analgesics).- Chapter 3. Drugs for Gastrointestinal Disorders.- Chapter 4. Drugs for Respiratory Diseases.- Chapter 5. Drugs for Cardiovascular Diseases.- Chapter 6. Drugs for Metabolic Disorders.- Chapter 7. Drugs for Her and Him.- Chapter 8. Drugs for Neurological Disorders.- Chapter 9. Drugs for Mental Disorders.- Chapter 10. Drugs for Eye Diseases.- Chapter 11. Drugs for Cancer and Autoimmune and Infectious Diseases.
£18.74
Springer Manufacturing of Gene Therapeutics
Book SynopsisSomatic Gene Therapy, Paradigm Shift or Pandora's Box: A Perspective on Gene Therapy.- Gene Therapy for Cancer: Deceiving the Malignant Cell.- Gene Self-Assembly (GENSA): Facilitating the Construction of Genes and Vectors.- Gene Expression.- Tumour Genotype and Response to Cytotoxic Gene Therapy.- Protein Binding Matrices: Tools for Phenol-free Cloning and Vector Assembling.- Gene Transfer into Eukaryotic Cells.- Plasmid DNA Manufacturing.- Quality Assurance and Quality Control for Viral Therapeutics.- Analytical Assays to Characterise Adenoviral Vectors and Their Applications.- Validation of Gene Therapy Manufacturing Processes: A Case Study for Adenovirus Vectors.- Gene Delivery.- Regulatory Issues in Gene Therapy. Good Science - Good Sense.- Regulatory Aspects in Gene Therapy: Special Highlights on European Regulation.- Regulatory Issues for Process Development and Manufacture of Plasmids Under Contract.- Risk Assessment in Gene Therapy.Table of ContentsSomatic Gene Therapy, Paradigm Shift or Pandora's Box: A Perspective on Gene Therapy; M. Lawler. Gene Therapy for Cancer: Deceiving the Malignant Cell; M. Lawler. Gene Self-Assembly (GENSA): Facilitating the Construction of Genes and Vectors; C.P. Hodgson. Gene Expression; J. Kaur, et al. Tumour Genotype and Response to Cytotoxic Gene Therapy; P.T. Daniel, et al. Protein Binding Matrices: Tools for Phenol-free Cloning and Vector Assembling; V.I. Evtushenko. Gene Transfer into Eukaryotic Cells; M. Weber. Plasmid DNA Manufacturing; M. Schleef, et al. Quality Assurance and Quality Control for Viral Therapeutics; S.S. Kuwahara. Analytical Assays to Characterise Adenoviral Vectors and Their Applications; E. Lehmberg, et al. Validation of Gene Therapy Manufacturing Processes: A Case Study for Adenovirus Vectors; D. Vacante, et al. Gene Delivery; A. Anand. Regulatory Issues in Gene Therapy. Good Science - Good Sense; N. Chew, J.A. Cavagnaro. Regulatory Aspects in Gene Therapy: Special Highlights on European Regulation; O. Cohen-Haguenhauer. Regulatory Issues for Process Development and Manufacture of Plasmids Under Contract; J.M. Jenco. Risk Assessment in Gene Therapy; A. Anand, S.K. Arora. Index.
£161.99
Springer-Verlag New York Inc. Advanced Organic Chemistry
Book Synopsis1: Chemical Bonding and Molecular Structure.- 2: Stereochemistry, Conformation, and Stereoselectivity.- 3: Structural Effects on Stability and Reactivity.- 4: Nucleophilic Substitution.- 5: Polar Addition and Elimination Reactions.- 6: Carbanions and Other Carbon Nucleophiles.- 7: Addition, Condensation and Substitution Reactions of Carbonyl Compounds.- 8: Aromaticity.- Aromatic Substitution.- 9: Concerted Pericyclic Reactions.- 10: Free Radical Reactions.- 11: Photochemistry.Trade ReviewFrom the reviews of the fifth edition:“Carey and Sundberg had written the most detailed and briliant account in the subject of organic chemistry. … The book provides an abundance of reaction examples organized in schemes. It makes studying very effective and helpful. … Advanced undergraduates and graduate students will welcome this new edition and the depth of materials covered.” (Philosophy, Religion and Science Book Reviews, bookinspections.wordpress.com, May, 2014)Table of ContentsChemical Bonding and Molecular Structure.- Stereochemistry, Conformation, and Stereoselectivity.- Structural Effects on Stability and Reactivity.- Nucleophilic Substitution.- Polar Addition and Elimination Reactions.- Carbanions and Other Carbon Nucleophiles.- Addition, Condensation and Substitution Reactions of Carbonyl Compounds.- Aromaticity.- Aromatic Substitution.- Concerted Pericyclic Reactions.- Free Radical Reactions.- Photochemistry.
£71.99
Springer-Verlag New York Inc. Space Pharmacology
Book SynopsisSpace Pharmacology is a review of the current knowledge regarding the use of pharmaceuticals during spaceflights. Every section begins with a topic overview, and is followed by a discussion of published data from spaceflight, and from ground experiments meant to model the spaceflight situation.Table of ContentsChapter 1: Introduction.- Chapter 2: Absorption.- Chapter 3: Distribution.- Chapter 4: Metabolism and Excretion.- Chapter 5: Central Nervous System.- Chapter 6: Cardiovascular System.- Chapter 7: Gastrointestinal System.- Chapter 8: Musculoskeletal System.- Chapter 9: Multiple Systems Spaceflight Effects.- Chapter 10: Conclusions - Special Challenges of Long Duration Exploration.- References.- Abbreviations.
£49.49
Springer Nature Switzerland AG Physician's Guide to the Diagnosis, Treatment,
Book SynopsisThis updated and enlarged second edition is a unique source of information on the diagnosis, treatment, and follow-up of metabolic diseases. The clinical and laboratory data characteristic of rare metabolic conditions can be bewildering for clinicians and laboratory personnel alike – reference laboratory data is scattered, and clinical descriptions can be obscure. The new Physician’s Guide with the additional more than 600 diseases now featured, documents 1200 conditions grouped according to type of disorder, organ system affected (e.g. liver, kidney, etc) or phenotype (e.g. neurological, hepatic, etc). It includes relevant clinical findings and highlights the pathological values for diagnostic metabolites. Guidance on appropriate biochemical genetic testing is also provided and established experimental therapeutic protocols are described, with recommendations on follow-up and monitoring. The authors are acknowledged experts, and the book is a valuable desk reference for all who deal with inherited metabolic diseases.Chapter 73 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.comTable of ContentsPart 1. GENERAL SUBJECTS AND PROFILES.- 1. Newborn Screening for Inborn Errors of Metabolism.- 2. Simple Tests and Routine Chemistry.- 3. Amino Acids.- 4. Organic Acids.- 5 .Acylcarnitines.- 6. Lysosomals.- 7. Untargeted Metabolomics – Next Generation Metabolic Screening.- 8. MRI and In Vivo Spectroscopy of the Brain.- 9. Genomic Approaches for the Diagnosis of Inborn Errors of Metabolism.- 10. Other-omics Approaches and Their Integration for the Diagnosis and Treatment of Inborn Errors of Metabolism.- 11. Emergency Diagnostic Procedures and Emergency Treatment.- 12. Nosology of Inborn Errors of Metabolism.- Part 2. DISORDERS OF NITROGEN-CONTAINING COMPOUNDS.- 13. Purine and Pyrimidine Disorders.- 14. Disorders of nucleotide metabolism.- 15. Disorders of Creatine Metabolism.- 16. Disorder of Glutathione Metabolism.- 17. Disorders of Ammonia Detoxification.- 18. Amino Acid Transport Defects.- 19. Disorders of Monoamine Metabolism.- 20. Disorders of Phenylalanine and Tetrahydrobiopterin Metabolism.- 21. Disorders of Tyrosine Metabolism.- 22. Disorders of Sulfur Amino Acid and Hydrogen Sulfide Metabolism.- 23. Disorders of Branched-Chain Amino Acid Metabolism.- 24. Disorders of Beta and Gamma Amino Acids.- 25. Amino Acid Synthesis Deficiencies.- 26. Disorders of Glycine Metabolism.- 27. Disorders of Lipoic Acid and Iron-Sulfur Protein Metabolism.- Part 3. DISORDERS OF VITAMINS, COFACTORS, METALS AND MINERALS.- 28. Disorders of Cobalamin Metabolism.- 29. Disorders of Folate Metabolism and Transport.- 30. Disorders of Biotin Metabolism.- 31. Thiamine Disorders.- 32. Disorders of Riboflavin Metabolism.- 33. Disorders of Niacin, NAD and Panthotenate Metabolism.- 34. Vitamin B6-Dependent and Responsive Disorders.- 35. Molybdenum Cofactor Disorders.- 36. Disorders of Copper, Zinc and Selenium Metabolism.- 37. Disorders of Iron Metabolism.- 38. Disorders of Manganese Metabolism.- Part 4. DISORDERS OF CARBOHYDRATES.- 39. Disorders of Carbohydrate Absorption, Transmembrane Transport and Metabolism.- 40. Disorders of the Pentose Phosphate Pathway and Polyol Metabolism.- 41. Hyperinsulinism.- Part 5. MITOCHONDRIAL DISORDERS OF ENERGY METABOLISM.- 42. Disorders of the Pyruvate Metabolism and the Krebs Cycle.- 43. Disorders of Mitochondrial Carriers.- 44. Isolated Mitochondrial Complex Deficiencies.- 45. Disorders of Replication, Transcription and Translation of Mitochondrial DNA.- 46. Disorders of mitochondrial homeostasis, dynamics, protein import and quality control.- 47. Primary Coenzyme Q10 Deficiencies.- Part 6. DISORDERS OF LIPIDS.- 48. Mitochondrial Fatty Acid Oxidation Disorders.- 49. Disorders of Glycerol Metabolism.- 50. Disorders of Ketone Body Metabolism and Transport.- 51. Disorders of Complex Lipids.- 52. Disorders of Eicosanoid Metabolism.- 53. Disorders of Lipoprotein Metabolism.- 54. Disorders of Cholesterol Biosynthesis.- 55. Disorders of Adrenals and Gonads.- 56. Disorders of Bile Acid Synthesis. Part 7. DISORDERS OF TETRAPYRROLES.- 57. Disorders of Heme Metabolism.- 58. Inherited Disorders of Bilirubin Metabolism.- Part 8. STORAGE DISORDERS.- 59. Disorders of Autophagy.- 60. Lipidoses: The Sphingolipidoses, Lysosomal Acid Lipase Deficiency and Niemann Pick type C.- 61. The Neuronal Ceroid Lipofuscinoses.-62. Mucolipidoses, Multiple Sulfatase deficiency, Cathepsin K and C Deficiency.- 63. Oligosaccharidoses and Sialic Acid Disorders.- 64. The Mucopolysaccharidoses.- 65. Cystinosis.- Part 9. DISORDERS OF PEROXISOMES AND OXALATE.- 66. Peroxisomal Disorders.- 67. Disorders for Oxalate Metabolism.- Part 10. CONGENITAL DISORDERS OF GLYCOSYLATION.- 68. Congenital Disorders of Glycosylation.- Part 11. VARIOUS.- 69. Cerebral Organic Acidurias.- 70. 3-Methylglutaconic acidurias.- 71. Biochemical Phenotypes of Questionable Clinical Significance.- 72. Knowledgebase of Inborn Errors of Metabolism (IEMbase): A Practical Approach.- 73. WikiPathways: Integrating Pathway Knowledge with Clinical Data.
£179.99
Springer International Publishing AG Polypharmacology: Principles and Methodologies
a huge range and FREE tracked UK delivery on ALL orders.
£999.99
Springer International Publishing AG Messenger RNA Therapeutics
a huge range and FREE tracked UK delivery on ALL orders.
£999.99
Springer International Publishing AG Principles and Practices of Lyophilization in
Book SynopsisThe biotechnology/biopharmaceutical sector has tremendously grown which led to the invention of engineered antibodies such as Antibody Drug Conjugates (ADCs), Bispecific T cell engager ( BITES), Dual Variable Domain ( DVD), Chimeric Antigen Receptor - Modified Tcells (CART) that are currently being used as therapeutic agents for immunology and oncology disease conditions. In addition to other pharmaceuticals and biopharmaceuticals, all these novel formats are fragile with respect to their stability/structure under processing conditions meaning marginal stability in the liquid state and often require lyophilization to enhance their stability and shelf-life. This book contains chapters/topics that will describe every aspect of the lyophilization process and product development and manufacturing starting from the overview of lyophilization process, equipment required, characterization of the material, design and development of the formulation and lyophilization process, various techniques for characterization of the product, scale-up/tech-transfer and validation. It also describes the application of CFD coupled with mathematical modeling in the lyophilization process and product development, scale-up, and manufacturing. Additionally, Principles and Practice of Lyophilization Process and Product Development contains an entire dedicated section on “Preservation of Biologicals” comprised of nine chapters written by experts and including case studies.Table of Contents1. Overview of Freeze Drying2. Characterization and Determination of Freeze Drying Properties of Frozen Formulations- Case Studies3. Beyond pH: Acid/base relationships in frozen and freeze-dried pharmaceuticals4. Concepts and Strategies in the Design of Formulation for Freeze Drying5. Formulation Design for Freeze Drying - Case studies of Stabilization of Proteins6. Challenges and Considerations in the Development of a High Protein Concentration Lyophilized Drug Product7. Freeze-drying of thermosensible pharmaceuticals with organic co-solvent + water formulations8. Primary container closure system selection for lyophilized drug products9. Vial Breakage During Lyophilization10. The Nucleation of Ice11. Stresses, Stabilization, and Recent Insights in Freezing of Biologics12. Lyophilization Process Understanding and Scale-up using ab initio Vial Heat Transfer Modeling13. Secondary drying: Challenges and Considerations14. Design and Process Considerations in Spray Freeze Drying15. LyoPRONTO: Deterministic and Probabilistic Modeling. Tutorial and Case Study16. Utilizing Solid-State NMR Spectroscopy to Assess Properties of Lyophilized Formulations17. Design of Moisture Studies for a Lyophilized Product18. Laser-Based Headspace Moisture Analysis for Rapid Nondestructive Moisture Determination of Lyophilized Products19. Application of PAT in Real-time Monitoring and Controlling of Lyophilization Process20. Process Analytical Technology (PAT) for Lyophilization Process Monitoring and End Point Detection21. Advances in Process Analytical Technology – A Small Scale Freeze-Dryer for Process Analysis, Optimization, and Transfer Advances in Process Analytical Technology – A Small Scale Freeze-Dryer for Process Analysis, Optimization, and Transfer22. Overview of Heat and Mass Transfer Modeling in Lyophilization to Create Design Spaces and Improve Process Analytical Tool (PAT) Capability23. Application of QbD elements in the Development and Manufacturing of a Lyophilized product.- Characterization of Freeze Dryer24. Characterization of Freeze Dryer25. Scale-up and Technology Transfer of a Lyophilization Process26. Lyophilization Validation: Process Design and Modeling27. Lyophilization Validation: Process Qualification and Continued Process Verification28. Homogeneity Assessment of Lyohilized Biological Drug Products During Process Performance Qualification29. Informed Manufacturing through the use of Big Data Analytics for Freeze Drying Process & Equipment30. Multivariate Analysis for Process Understanding, Continuous Process Verification and Condition Monitoring of Lyophilization Processes31. Lyophilized Drug Product Cake Appearance: What Is Acceptable?
£999.99
Springer International Publishing AG Good Laboratory Practices for Forensic Chemistry
Book SynopsisGood Laboratory Practices for Forensic Chemistry acknowledges the limitations that often challenge the validity of data and resultant conclusions. Eight chapters examine current practices in analytical chemistry as well as business practices, guidelines and regulations in the pharmaceutical industry to offer improvements to current practices in forensic chemistry. It discusses topics ranging from good manufacturing practices (GMP), good laboratory practices (GLP), the International Conference on Harmonisation (ICH), quality assurance (QA), and quality risk management (QRM), among others. This book is a guide for scientists, professors, and students interested in expanding their knowledge of forensic chemistry.Table of Contents.- 1 Introduction.- 2 What is Science .- 3 Forensic Chemistry .- 4 Code of Federal Regulations (21CFR) Guidance’s.- 5 International Committee on Harmonization (ICH).- 6 International Organization for standards.- 7 Statistical Considerations.- 8 Conclusions.
£33.74
Birkhauser Verlag AG Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems
Book SynopsisThis book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system. Trade Review“The purpose is to provide organ system-based summaries of spontaneous pathology and common responses to xenobiotics. … used as a textbook or reference for students, as an informative resource for novices in the field, and as a reference for researchers in the immune toxicology field. It also can be educational for the lay public who are interested in learning immunopathology in xenobiotics or general basic immunology. … a terrific book that I will certainly integrate into my graduate teaching.” (Hongmin Ni, Doody's Book Reviews, November, 2017)Table of ContentsThymus.- Spleen.- Lymph node.- Mucosa-associated lymphoid tissues.- Immunopathology of the nervous system.- Immunopathology of the urinary system.- Immunopathology of the hepatobiliary system.- Immunopathology of the respiratory system.- Immunopathology of the cardiovascular system.- Immunopathology of the male reproductive tract.- Immunopathology of the female reproductive tract and mammary gland.- Immunopathology of the musculoskeletal system.- Immunopathology of the endocrine system.- Ocular Immunopathology.- Immunopathology of Drug and Toxin-related Skin Reactions.
£161.99
Springer International Publishing AG Nanotechnology Applied To Pharmaceutical Technology
a huge range and FREE tracked UK delivery on ALL orders.
£161.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Polymer Therapeutics I: Polymers as Drugs, Conjugates and Gene Delivery Systems
Table of Contents1 Duncan, H. Ringsdorf, R. Satchi-Fainaro: Polymer Therapeutics: Polymers as Drugs, Drug and Protein Conjugates and Gene Delivery Systems: Past, Present and Future Opportunities.- 2 P.K. Dhal, S.R. Holmes-Farley, C.C. Huval, T.H. Jozefiak: Polymers as Drugs.- 3 R.J. Amir, D. Shabat: Domino Dendrimers.- 4 G. Pasut, F.M. Veronese: PEGylation of Proteins as Tailored Chemistry for Optimized Bioconjugates.- E. Wagner, J. Kloeckner: Gene Delivery Using Polymer Therapeutics.-
£261.32
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Heterocyclic Antitumor Antibiotics
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£161.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Peptide Hybrid Polymers
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£221.27
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Bioactive Heterocyles I
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£221.27
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG QSAR and Molecular Modeling Studies in Heterocyclic Drugs I
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£261.32
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Regulated Systems for Multiphase Catalysis
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£999.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Bioactive Heterocycles II
a huge range and FREE tracked UK delivery on ALL orders.
£161.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Bioactive Heterocycles III
a huge range and FREE tracked UK delivery on ALL orders.
£999.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Bioactive Heterocycles IV
a huge range and FREE tracked UK delivery on ALL orders.
£999.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Anthracycline Chemistry and Biology II: Mode of Action, Clinical Aspects and New Drugs
Book SynopsisThis series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts. The series is still valid and useful after five or ten years. More information as well as the electronic version of the whole content is available at: springerlink.com.Table of ContentsG.L. Beretta, F. Zunino: Molecular Mechanisms of Anthracycline Activity.- P. Menna, E. Salvatorelli, L. Gianni, G. Minotti: Anthracycline Cardiotoxicity.- M.L. Capobianco, C.V. Catapano: Daunomycin-TFO Conjugates for Downregulation of Gene Expression.- F. Kratz: Acid-Sensitive Prodrugs of Doxorubicin.- J.-C. Florent, C. Monneret: Doxorubicin Conjugates for Selective Delivery to Tumors.- T.H. Koch, B.L. Barthel, B.T. Kalet, D.L. Rudnicki, G.C. Post, D.J. Burkhart: Anthracycline–Formaldehyde Conjugates and Their Targeted Prodrugs - F.-M. Arcamone: Sabarubicin.- M. Broggini: Nemorubicin
£179.99
Springer The Biological Effects of Glutamic Acid and Its Derivatives
Book Synopsisthe GABA increase takes place and (2) the area of the brain that may mediate the anticonvulsant Investigation of the physiology, biochemistry, activity. Three compounds that increase brain pharmacology and anatomy of GAB A and GABA GABA by distinct mechanisms were used in these containing neural systems, continues to reveal the studies: di-n-propylacetate (DPA, sodium val rich complexities associated with this neuroactive proate, Depakene(R)), amino-oxyacetic acid amino acid (see recent symposia 1,2,3). Advances (AOAA) and y-vinyl GABA (GVG). in the pharmacology of GABA-mimetic agents In the next sections, the metabolism of GABA have resulted in the development of compounds and a brief historical account of the relationship that can selectively activate GABA receptors (4,5, between GABA and anticonvulsant activity are 6, 7), inhibit the synthetic and degradative enzymes outlined followed by a discussion ofthe biochemical for GABA (8, 9) or affect the neuronal and glial and pharmacological effects of the three drugs. In uptake processes for GABA (10, 11). This has particular, the literature pertaining to the suppres already had a significant impact on our under sion of seizures and the correlation between anti standing of the role of GABA in convulsions and a convulsant action and increases in brain G ABA will range of other CNS functions including feeding be examined. (12), cardiovascular control (13), motor activity (14) and release of pituitary hormones (15). Before 1.Table of Contentsto ‘Developments in molecular and cellular biochemistry’.- 1. Hippocampal glutamate receptors.- 2. Enzymatic synthesis and function of folypolyglutamates.- 3. ?-Aminolevulinic acid and amino acid neurotransmitters.- 4. ?-Glutamylamine cyclotransferase.- 5. GABA and the enteric nervous system.- 6. Post-translational carboxylation of preprothrombin.- 7. Glutamate and aspartate agonists structurally related to ibotenic acid.- 8. GABA agonists.- 9. Pharmacology of GABA-mediated inhibition of spinal cord neurons in vivo and in primary dissociated cell culture.- 10. Molecular characteristics of glutamate receptors in the mammalian brain.- 11. Pyroglutamic acid.- 12. Gamma-carboxyglumatic acid.- 13. Folypoly-?-glutamate synthesis by bacteria and mammalian cells.- 14. Immunocytochemical and autoradiographic localization of GABA system in the vertebrate retina.- 15. L-glutamate transport in renal plasma membrane vesicles.- 16. Glutamate as a precursor of GABA in rat brain and peripheral tissues.- 17. The GABA postsynaptic membrane receptor-ionophore complex.- 18. The stimulation of ion fluxes in brain slices by glutamate and other excitatory amino acids.- 19. Alterations of central GABAergic activity in neurologic and psychiatric disorders: evaluation through measurements of GABA and GAD activity in cerebrospinal fluid.- 20. Cellular compartments of GABA in brain and their relationship to anticonvulsant activity.- 21. Pteroylpolyglutamates.- 22. Glutamate receptor binding in insects and mammals.- 23. ?-Glutamyl transpeptidase: catalytic, structural and functional aspects.- 24. Utilization of GABA in Substantia Nigra.
£44.99
Springer Immunologically Active Peptides
Table of ContentsTuftsin, a natural activator of phagocytic functions including tumoricidal activity.- Antitumor effect of tuftsin.- N?-formyl-norleucyl-phenylalanyl chloromethylketone.- Muramyl peptides.- Modulation of terminal deoxynucleotidyl transferase activity by thymosin.- Isolation of three separate anaphylatoxins from complement-activated human serum.- The serum thymic factor.- Tuftsin Thr-Lys-Pro-Arg.- Tuftsin analogs and their biological activity.- Macrophage activation by tuftsin and muramyl-dipeptide.- Induction of T lymphocyte differentiation by thymic factors.- Bacterial activity of tuftsin.
£44.99
Springer Immunoassays for the 80s
Book SynopsisAnalyses for naturally occurring biological substances or administered materials have been with us for many years. These were usually based on the physical or chemical characteristics of the substances to be measured. However in recent years there has been an explosion of interest in analytical methods which made use of the high specificity and sensitivity of im munological reactions. These methods can be very simple in terms of technical procedures and can usually be performed on minute samples of biological fluids - factors which have ensured their ready acceptance in most laboratories. Recently there have been numerous meetings on technical aspects of particular immunoassays and on their application in specific diseases. We felt however that the time was ripe for an 'overview' of the whole field. To this end a conference on 'Immunoassays for the 80s' was held at the Zoological Society of London in 1980, and this book is largely based on that meeting. Both the immunoassay techniques and their numerous applications were discussed and are dealt with at length in this volume. The editors wish to thank all the contributors for their chapters and to acknowledge the debt they owe to Jean Ryan (NLCM) without whose organization and assistance this volume would not have been completed. A.V., D.B., A.B.Table of ContentsI Immunoassay Techniques.- 1. Historical perspectives.- 2. Merits and disadvantages of different labels and methods of immunoassay.- 3. Assays utilizing red cells as markers.- 4. Particle counting immunoassay (PACIA): an automated non-radioisotopic immunoassay method, suitable for antigens, haptens, antibodies and immune complexes.- 5. Precipitation and related immunoassay techniques.- 6. Radioimmunoassay.- 7. Heterogeneous enzyme immunoassays.- 8. Immunoassays employing reactants labelled with a fluorophore.- 9. Chemiluminescence and its use in immunoassay.- 10. New homogeneous assay methods for the determination of proteins.- 11. Antisera in immunoassays with special reference to monoclonal antibodies to human immunoglobulins.- 12. External quality assessment schemes for immunoassays.- 13. The control of performance in immunoassays.- 14. Components in a model for the production of reference materials with special reference to immunoassays.- 15. Standardization of immunological reagents.- II Applications of Immunoassays.- 16. Steroid immunoassays in endocrinology.- 17. Immunoassays in pharmacology and toxicology.- 18. Immunoassays in autoimmune disease.- 19. Radioimmunoassays in allergy.- 20. Immunoassay screening for open neural-tube defects: practical aspects.- 21. Immunoassays in haematology.- 22. Immunoassays in tissue typing.- 23. Immunoassays for acute phase proteins.- 24. Rapid virus diagnosis.- 25. Viral hepatitis with special reference to hepatitis B.- 26. Immunoassays for hepatitis A.- 27. Immunoassays for the TORCH programme.- 28. Current status of specific IgM antibody assays.- 29. Enzyme immunoassays in bacteriology.- 30. Immunoassays in mycology.- 31. Some applications of immunoassays in tropical parasitic infections.- 32. Immunoassays in veterinary medicine.- 33. Immunoassays in plant virology.
£40.49
Springer Prevention in nephrology
Book SynopsisPrevention of renal disease: an overview.- Evaluation and significance of renal functional reserve in health and disease.- Angiotensin I: Converting enzyme inhibition in models of progressive glomerulosclerosis.- Prevention of nephrotoxicity of beta-lactam antibiotics.- Prevention of analgesic nephropathy.- Efficacy and nephrotoxicity of aminoglycoside.- Prevention of cadmium and lead nephropathy.- Prevention of bone disease in renal failure.- Kidney function, hypertension and clinical diabetic nephropathy in type I diabetes.- Drug management of hyperlipidemia.- Index of subjects.Table of ContentsPrevention of renal disease: an overview.- Evaluation and significance of renal functional reserve in health and disease.- Angiotensin I: Converting enzyme inhibition in models of progressive glomerulosclerosis.- Prevention of nephrotoxicity of beta-lactam antibiotics.- Prevention of analgesic nephropathy.- Efficacy and nephrotoxicity of aminoglycoside.- Prevention of cadmium and lead nephropathy.- Prevention of bone disease in renal failure.- Kidney function, hypertension and clinical diabetic nephropathy in type I diabetes.- Drug management of hyperlipidemia.- Index of subjects.
£85.49
Springer Clinical Laboratory Science in the Changing Scene of Health Care: Proceedings of the sixth ECCLS Seminar held at Cologne, West Germany, 8th–10th May, 1985
Book SynopsisList of Contributors ix PART 1 CURRENT CONCEPTS OF HEALTH AND HEALTH CARE 1 A European overview of the health care scene KS Johansen 3 Is there a European concept of health and health care? 2 JGW Wittkiimper 7 3 The effects of health and safety legislation on the practice of clinical laboratory science A Berlin, AE Bennett and WJ Hunter 19 4 Current economic, technical and political pressures at the laboratory level: some benefits towards health care delivery JG Lines and N Sanders 33 PART 2 THE CLINICAL LABORATORY IN THE CHANGING SCENE OF HEALTH CARE 5 The clinical laboratory in the changing scene of health care as seen by a professional society member M Roth 41 6 The clinical laboratory in the changing scene of health care as seen by an industry member JE Barclay 45 7 The clinical laboratory in the changing scene of health care as seen by a health agency member R Netter 55 8 The clinical laboratory in the changing scene of health care as seen in the USA R Nadeau 59 v CONTENTS PART 3 WOULD THE VALUE OF CLINICAL LABORATORY SCIENCE BE INCREASED BY FURTHER WRITTEN AND MATERIAL STANDARDS? 9 Would the value of clinical laboratory science be increased by further written and material standards in histology? J Rygaard 67 10 Would the value of clinical laboratory science be increased by further written and material standards in cytopathology? OAN Husain 73 11 Would the value of clinical laboratory science beTable of Contents1 Current Concepts of Health and Health Care.- 1 A European overview of the health care scene.- 2 Is there a European concept of health and health care?.- 3 The effects of health and safety legislation on the practice of clinical laboratory science.- 4 Current economic, technical and political pressures at the laboratory level: some benefits towards health care delivery.- 2 The Clinical Laboratory in the Changing Scene of Health Care.- 5 The clinical laboratory in the changing scene of health care as seen by a professional society member.- 6 The clinical laboratory in the changing scene of health care as seen by an industry member.- 7 The clinical laboratory in the changing scene of health care as seen by a health agency member.- 8 The clinical laboratory in the changing scene of health care as seen in the USA.- 3 Would The Value Of Clinical Laboratory Science be Increased by Further Written and Material Standards?.- 9 Would the value of clinical laboratory science be increased by further written and material standards in histology?.- 10 Would the value of clinical laboratory science be increased by further written and material standards in cytopathology?.- 11 Would the value of clinical laboratory science be increased by further written and material standards in microbiology?.- 12 Would the value of clinical laboratory science be increased by further written and material standards in immunology?.- 13 Would the value of clinical laboratory science be increased by further written and material standards in haematology?.- 14 Would the value of clinical laboratory science be increased by further written and material standards in clinical chemistry?.- 15 Would the value of clinical laboratory science be increased by further written and material standards in toxicology?.- 4 Future Eccls Involvement.- 16 Future ECCLS involvement as seen by industry.- 17 Future ECCLS involvement as seen by health agencies.- 18 Future ECCLS involvement as seen by professional societies.
£44.99
Springer Practical Developments in Inherited Metabolic Disease: DNA Analysis, Phenylketonuria and Screening for Congenital Adrenal Hyperplasia: Proceedings of the 23rd Annual Symposium of the SSIEM, Liverpool, September 1985
Table of ContentsThe 23rd Annual Symposium of the SSIEM: Liverpool.- to recombinant DNA.- Human biochemical genetics of enzyme proteins in the new age of molecular genetics.- Direct DNA analysis in family studies.- Application and limitations of direct DNA analysis in genetic prediction.- DNA analysis for ornithine transcarbamylase deficiency.- Molecular genetics of PKU.- Human DNA repair defects.- Molecular basis of ai-antitrypsin deficiency and its potential therapy by gene transfer.- Direct alteration of a gene in the human genome.- Diabetes mellitus, atherosclerosis, and the 5’ flanking polymorphism of the human insulin gene.- Workshop on Screening for Congenital Adrenal Hyperplasia (steroid 21-hydroxylase deficiency).- Clinical aspects of congenital adrenal hyperplasia: early diagnosis and prognosis.- Biochemical aspects of congenital adrenal hyperplasia.- Large-Scale Pilot Studies.- Review of CAH screening programmes and the Scottish experience.- Neonatal screening programme for congenital adrenal hyperplasia in a homogenous Caucasian population.- Neonatal screening for congenital adrenal hyperplasia: a pilot study in France.- Existing Clinical Diagnoses.- Congenital adrenal hyperplasia in Birmingham: a retrospective analysis (1958-1985).- Prevalence of adrenal 21-hydroxylase deficiency in neonates born in the West Midlands: a retrospective study.- Clinical Symposium - Phenylketonuria.- and explanation.- Maternal phenylketonuria.- Dietary problems of phenylketonuria: effect on CNS transmitters and their possible role in behaviour and neuropsychological function.- Diagnosis in relationship to treatment of hyperphenylalaninaemia.- Problems related to diet management of maternal phenylketonuria.- Short Communications.- Preface and Free Communications.- Molecular biology of phenylalanine hydroxylase.- Hepatic phenylalanine hydroxylase and dietary tolerance in hyperphenylalaninaemic patients.- Phenylalanine metabolites in treated phenylketonuric children.- Magnesium-deficient rickets in a phenylketonuric patient on dietary treatment.- Termination of strict diet in phenylketonuria: neurophysiological, psychological and biochemical studies.- Effects of stopping phenylalanine-restricted diet on intellectual progress of children with phenylketonuria.- Maternal hyperphenylalaninaemia: dietary treatment during pregnancy.- Maternal hyperphenylalaninaemia in Israel.- Maternal phenylketonuria with increased tyrosine supplements.- Screening for phenylketonuria in Yugoslavia (SR Croatia) 1979–1984.- Incidence of phenylketonuria and hyperphenylalaninaemia in a sample of the Turkish newborn population.- Atypical phenylketonuria with mild mental retardation caused by tetrahydrobiopterin deficiency in a Chinese family.- Dihydropteridine reductase deficiency: clinical, biochemical and therapeutic aspects.- Partial dihydropteridine reductase deficiency and mental retardation.- Urine amino acid analysis by HPLC in the investigation of inborn errors of metabolism.- Plasma amino acid patterns in critically ill children.- Treatment of hereditary tyrosinaemia (fumarylacetoacetase deficiency) by enzyme substitution.- Presentation of the data of the Italian registry for oculocutaneous tyrosinaemia.- A new case of hyperlysinaemia with saccharopinuria.- Failure of early diazepam treatment in a neonate with non-ketotic hyperglycinaemia.- Gyrate atrophy of the choroid and retina: 3 cases in one Italian family.- Methylenetetrahydrofolate reductase and methyltetrahydrofolate methyltransferase in human fetal tissues and chorionic villi.- Kinetic studies on the glucose-6-phosphate transport system in rat hepatic microsomal membrane.- Long term cornstarch therapy in glycogen storage disease types I, lb and III.- Galactose-l-phosphate-uridyl transferase activity in chorionic villi: a first trimester prenatal diagnosis of galactosaemia.- Molecular heterogeneity of McArdle disease.- Decreased affinity of phosphorylase ? for glucose-1 -phosphate in polymorphonuclear leukocytes of patients with glycogenosis type VI.- The diagnosis and treatment of a patient with medium-chain acyl-CoA dehydrogenase deficiency: overnight fasting does not result in the expected urinary metabolite profile.- A new case of familiar C6-C14 dicarboxylic aciduria with favourable evolution.- Pyruvate carboxylase responsive to ketosis in a multiple carboxylase deficiency patient.- Neonatal screening for biotinidase deficiency: an update.- GM2 gangliosidosis with hexosaminidase A and B defect: report of a family with motor neuron disease-like phenotype.- A comparison between hepatocytes and macrophages of sphingomyelin, cholesterol and acid lipase in various types of Niemann-Pick disease.- Juvenile dystonia without vertical gaze paralysis: Niemann-Pick type C disease.- Pre- and postnatal diagnosis of the cerebro-hepato-renal (Zellweger) syndrome via a simple method directly demonstrating the presence or absence of peroxisomes in cultured skin fibroblasts, amniocytes or chorionic villi fibroblasts.- Impaired cholesterol side chain cleavage activity in liver from patients with cerebro- hepato-renal (Zellweger) syndrome in relation to the accumulation of di- and trihydroxycoprostanoic acid in serum.- Deficiency of dihydroxyacetonephosphate acyltransferase and catalase-containing particles in patients with infantile Refsum’s disease.- Peroxisomal abnormalities in rhizomelic chondrodysplasia punctata.- Cytogenetic studies of three families with ataxia-telangiectasia (Louis-Bar syndrome).
£40.49
Springer Organic Acidurias: Proceedings of the 21st Annual Symposium of the SSIEM, Lyon, September 1983 The combined supplements 1 and 2 of Journal of Inherited Metabolic Disease Volume 7 (1984)
Book SynopsisThe first symposium of the Society for the Study ofInborn valuable overview of advances in the application of Errors of Metabolism (SSIEM) on the organic acid urias chemical analysis of amniotic fluid to their early prenatal was held in Leeds in 1971 and published by the Society in diagnosis. The continuing complexity of diagnosis, 1972 (the 9th Annual SSIEM Symposium). Although biochemistry and aetiology ofthe dicarboxylic acid urias relatively few of these disorders were recognized at that has been admirably reduced by the papers from Dr time, the symposium was prompted by the then recent Gregersen and Dr Goodman, with Dr Goodman clearly identification between 1966 and 1970 of isovaleric identifying the primary defect in the polycystic variant of acidaemia, methylmalonic aciduria, propionic aci- multiple acyl CoA dehydrogenase deficiency ("glutaric daemia, pyroglutamic aciduria and 3-methylcrotonyl- aciduria type II") as a deficiency of electron transfer glycinuria. Identification and diagnosis of diseases of this flavoprotein (ETF) dehydrogenase. Dr Engel's paper kind had greatly improved primarily through the also provides a useful overview from currently available application of gas chromatography and mass spectro- data of the place of L-carnitine in the organic acid urias, metry to medicine, although the complexity of the an area in which rapid developments are occurring. The underlying biochemistry and the genetic heterogeneity of emerging understanding of the aetiologies of the the organic acidurias was not then realised.Table of ContentsPreface.- Section I: Clinical aspects: management and outcome.- Neonatal management of organic acidurias. Clinical update (Hudson Memorial Lecture).- Long term outcome of organic acidurias: survey of 105 French cases (1967-1983).- The management and long term outcome of organic acidaemias.- Prenatal diagnosis of the organic acidurias.- Symptoms and signs in organic acidurias.- Section II: Dicarboxylic acidurias and acyl-CoA dehydrogenase deficiencies.- Fatty acyl-CoA dehydrogenase deficiency: enzyme measurement and studies on alternative metabolism.- Glutaric acidaemia type II (multiple acyl-CoA dehydrogenation deficiency).- Carnitine metabolism and inborn errors.- Gas chromatography—mass spectrometry (GC—MS) diagnosis of 2 cases of medium chain acyl-CoA dehydrogenase deficiency.- The differential diagnosis of dicarboxylic aciduria.- Animal models for dicarboxylic aciduria.- Section III: Disorders of the respiratory chain and the lactic acidaemias.- Mitochondrial oxidative phosphorylation and respiratory chain: review.- Mitochondrial myopathies: disorders of the respiratory chain and oxidative phosphorylation.- Lactic acidaemia.- Pyruvate carboxylase deficiency.- Organic acids in urine of patients with congenital lactic acidoses: an aid to differential diagnosis.- Section IV: A new disorder: 4-hydroxybutyric aciduria.- Clinical review.- Biochemical findings.- Enzymology and mode of inheritance.- Section V: Short Communications.- Preface to Short Communications.- Free Communications.- Electron-transferring flavoprotein deficiency in the multiple acyl-CoA dehydrogenation disorders, glutaric aciduria type II and ethylmalonic-adipic aciduria.- Glutaric aciduria type II: multiple defects in isolated muscle mitochondria and deficient ?-oxidation in fibroblasts.- Glutaryl CoA dehydrogenase activity determined with intact electron-transport chain: application to glutaric aciduria type II.- Medium chain acyl-CoA dehydrogenase deficiency: apparent Km and Vmax values for fibroblast acyl-CoA dehydrogenase towards octanoyl-CoA in patient and control cell lines.- Mitochondrial myopathy with partial cytochrome oxidase deficiency and impaired oxidation of NADH-linked substrates.- L-Carnitine insufficiency in disorders of organic acid metabolism: response to L-carnitine by patients with methylmalonic aciduria and 3-hydroxy-3-methylglutaric aciduria.- An evaluation of urine lactate for detection of inborn errors of metabolism.- Metabolic acidosis versus a compensation of respiratory alkalosis in four children with Leigh’s disease.- Chemical diagnosis of dihydrolipoyl dehydrogenase deficiency.- 3-Hydroxy-3-methylglutaric, 3-methylglutaconic and 3-methylglutaric acids can be non-specific indicators of metabolic disease.- Different organic acid patterns in urine and in cerebrospinal fluid in a patient with biotinidase deficiency.- Biotinidase deficiency: the possible role of biotinidase in the processing of dietary protein-bound biotin.- Biotin-responsive multiple carboxylase deficiency (MCD): deficient biotinidase activity associated with renal loss of biotin.- Organic acids in urine: sample preparation for GC/MS.- Experience with prenatal diagnosis of propionic acidaemia and methylmalonic aciduria.- Methylmalonic aciduria with homocystinuria.- Two cases of ß-ketothiolase deficiency: a comparison.- L-Glyceric aciduria (primary hyperoxaluria type 2) in siblings in two unrelated families.- The antenatal diagnosis and aid to the management of hereditary tyrosinaemia by use of a specific and sensitive GC—MS assay for succinylacetone.- The enzyme defects in hereditary tyrosinaemia type I.- The possibility for prenatal diagnosis of PKU by linkage analyses based on phenylalanine hydroxylase locus specific DNA-polymorphisms.- Complementation between argininosuccinate synthetase-deficient and argininosuccinate lyase-deficient fibroblasts depends on intercellular communication.- Molecular lesion of non-ketotic hyperglycinaemia.- Prolidase deficiency: detection of cases by a newborn urinary screening programme.- Type Ib glycogen storage disease: an in vivo and in vitro study of two cases.- The lactate concentration of the urine, a parameter for the adequacy of dietary treatment of patients with glucose-6-phosphatase deficiency.- Sorbitol dehydrogenase deficiency in a family with congenital cataracts.- Thiamin-responsive megaloblastic anaemia: a disorder of thiamin transport?.- Acid esterase deficiency: comparison of biochemical findings in infantile and adult forms.- Steroid sulphatase deficiency. Steroid sulphatase and arylsulphatase C determination in normal and affected fibroblasts.- Steroid sulphatase deficiency is present in patients with the syndrome’ ichthyosis and male hypogonadism’ and with’ Rud syndrome’.
£40.49
Springer Metabolic Aspects of Alcoholism
Book SynopsisIn the first annual report on Alcohol and. Health to Congress (December, 1971), the then HEW Secretary Elliot L. Richardson called alcohol 'the most abused drug in the United States'. The report revealed that nine million Americans are alcohol abusers and that alcoholic individuals represent almost 10 % of the nation's work force. With spreading alcoholism, the incidence of physical damage due to alcohol has greatly increased. A question which is often raised is 'in which way does an alcoholic differ from a non-alcoholic?' Inquiries have focused on psychological make-up, behavioural differences and socioeconomic factors. More recently, however, physical differences have been delineated. Prior to the development of various disease entities, chronic ethanol exposure results in profound biochemical and morphological changes. Consequently an alcoholic does not respond normally to alcohol, or other drugs or even other toxic agents. Some of these persistent biochemical and morphological changes are the consequences of the injurious effects of ethanol, whereas others may represent the possible adaptive responses to the profound changes in intermediary metabolism which are a direct and im mediate consequence of the oxidation of ethanol itself. Differentiation between the effects of ethanol directly linked to its oxidation, and the adaptive and injurious effects of ethanol are not simple, and overlap is common. In general, however, metabolic effects are associated with the presence of relatively low ethanol concentrations, whereas injurious effects occur with high ethanol concentrations and/or after prolonged intake. High ethanol con centrations also produce so-called pharmacological effects.Table of Contents1. Metabolism of Ethanol.- 2. Metabolic Effects of Alcohol on the Liver.- 3. Metabolic Effects of Alcohol on the Intestine.- 4. The Effect of Alcohol on the Heart.- 5. Alcohol and Skeletal Disease.- 6. Metabolic Aspects of Alcoholism in the Brain.- 7. The Effect of Alcohol on Striated and Smooth Muscle.- 8. Metabolic Effects of Alcohol on the Blood and Bone Marrow.- 9. Metabolic Effects of Alcohol on the Endocrine System.
£44.99
Springer Immunochemistry in Clinical Laboratory Medicine: Proceedings of a symposium held at the University of Lancaster, March, 1978
Book SynopsisThe rapid growth of specific protein estimations in the clinical laboratory over the last 10 years has been due to advances both in methodology and in the understanding of the role of the various plasma proteins in health and disease. This expansion has been made possible by the development of both gel phase and fluid phase techniques for the estimation of proteins and the ready availability of antisera to individual plasma proteins. The specificity of the immunological reaction has allowed the more precise identification and estimation of individual plasma proteins than was possible with dye binding or other chemical techniques, but at the same time these methods have introduced other possible errors and pitfalls. Advances in understanding of the structure and function of various plasma proteins has pointed the way to new clinical applications of plasma protein estimation in the diagnosis and monitoring of disease. The Symposium, of which these are the proceedings, was planned to bring together a number of experts in the field to discuss the available methods and their clinical application.Table of ContentsSection One Methods and Problems in Immunochemistry.- 1 Electrophoresis and Immunoelectrophoresis.- 2 Radial immunodiffusion and rocket Immunoelectrophoresis.- 3 Automated immunoprecipitation and laser nephelometry.- 4 Antiserum requirements.- 5 Problems encountered in immunochemical technique methodology.- 6 Specific protein measurement and standardization.- 7 Quality control.- Section Two Specific Proteins in Laboratory Diagnosis.- 8 Structure and function of the immunoglobulins.- 9 Immunoglobulins in blood transfusion.- 10 Monoclonal proteins.- 11 Iron binding proteins.- 12 Albumin.- 13 The complement system.- 14 Alphafetoprotein in obstetrics.- 15 Alphafetoprotein in oncology.- 16 ?1-Antitrypsin.- 17 Haptoglobin and orosomucoid in lung and breast tumours.- Section Three Immunochemistry of Other Body Fluids.- 18 Urinary proteins.- 19 Immunochemistry of CSF proteins.- Discussion.
£40.49
Springer Verlag, Singapore Antibiotic Pharmacokinetic/Pharmacodynamic
Book SynopsisThis book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.Table of Contents1. Basic Pharmacokinetic Principles.- 2. Antibiotic Pharmacodynamics.- 3. Physiological Manifestations of Critical Illness.- 4. Dosing in Obese Critically Ill Patients.- 5. Hypoalbuminemia and Altered Protein Binding.- 6. Antibacterial Pharmacokinetic/Pharmacodynamic Considerations in the Critically ill.- 7. Augmented Renal Clearance.- 8. Antibiotic Dosing During Extracorporeal Membrane Oxygenation.- 9. Therapeutic Drug Monitoring: More than Avoiding Toxicity.- 10. Generic and Optimised Antibacterial Dosing Strategies in the Critically Ill.- 11. Antifungal PK/PD in the Critically Ill.- 12. Antibiotic Dosing in Pediatric Critically Ill Patients.- 13. Antibiotic Stewardship in the Intensive Care Unit.
£98.99
Springer Verlag, Singapore Polymer Gels: Science and Fundamentals
Book SynopsisThis book exclusively focuses on the science and fundamentals of polymer gels, as well as the numerous advantages that polymer gel-based materials offer. It presents a comprehensive collection of chapters on the recent advances and developments in the core science and fundamentals of both synthetic and natural polymer-based gels, and pays particular attention to applications in the various research fields of biomedicine and engineering. Key topics addressed include: polysaccharide-based gels and their fundamentals; stimuli-responsive polymer gels; polymer gels applied to enzyme and cell immobilization; chitosan-based gels for cancer therapy; natural polymeric and gelling agents; radiation dosimetry; polymeric gels as vehicles for enhanced drug delivery across the skin; transport in and through gel; and polymer gel nanocomposites and functional gels. The book’s extensive and highly topical coverage will appeal to researchers working in a broad range of fields in industry and academia alike.Table of ContentsBrea Gum Gel Capacity.- An Overview on Polymer Gels Applied to Enzyme and Cell Immobilization.- Xylan-Based Gels and Their Fundamentals.- Stimuli-Responsive Polymer Gels for Protein Delivery.- Polysaccharide-Based Polymergels.- Chitosan Based Gels for Cancer Therapy.- Natural Polymeric and Gelling Agents.- Radiation Dosimetry - A Different Prospective of Polymer Gel.- Polymeric Gels: Vehicles for Enhanced Drug Delivery Across Skin.- Graphene Oxide - Polymer Gels.- Transport in and Through Gel.- Strategizing Advance Application of Polymer Gels by Incorporation of Fillers.- Polymer Gels: New Materials for the Future.- Polymer Gel-Clay (Nano)Composites.- Functional Gels.- Molecular Distinction Between Structures of Nanoporous Siloxane Polymers.- Stimuli Responsive Polysaccharides Based Gels: Fundamental and Pharmaceutical Aspects.- Polymer Gel for Islet Encapsulation for Diabetes Therapy.
£151.99
Springer Verlag, Singapore Advances in Nanochemoprevention: Controlled Delivery of Phytochemical Bioactives
Book SynopsisThis book discusses the recent progress and advances in nanochemoprevention. Chemoprevention utilizes natural dietary compounds and has regained interest due to larger safety window and proven efficacy of such molecules in cancer treatments. Nanotechnology has revolutionized drug delivery through passive as well as active targeting. This book provides a comprehensive overview of phytochemical bioactives that are used in chemoprevention. It gives a comprehensive overview of the variety of natural molecules and types of nanoparticles as well as mechanistic aspects of their superior efficacy over plain drug molecules. The book concludes with summarizing the progress of pre-clinical results of developed formulations for cancer treatment using nano-chemoprevention.Table of Contents
£999.99
Springer Verlag, Singapore Pharmacokinetics: Basics to Applications
Book SynopsisThis textbook covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject. The book presents mathematical techniques, step- by-step descriptive equations, and applicable statistical analysis methods for the easy understanding of the topic. Further, it covers the preclinical applications and methods of pharmacokinetic aspects. The book also contains mathematical problems and questions related to pharmacokinetics for students. Special emphasis is on recent pharmacokinetic methods and their applications for managing clinical data and biostatistical approaches based on the current literature. This book is primarily meant for researchers and students from academic institutions and to R&D professionals.Table of ContentsChapter 1: Fundamentals of Pharmacokinetics.- Chapter 2: Drug absorption.- Chapter 3: The extent of drug absorption: bioavailability, clearance, bioequivalence, and protein-binding.- Chapter 4: Pharmacokinetic models and drug distribution.- Chapter 5: Drug metabolism .- Chapter 6: Drug elimination and nonlinear kinetics.- Chapter 7: Pharmacokinetic drug-drug interactions.- Chapter 8: Pharmacokinetic applications.- Chapter 9: Pharmacokinetic sample collection and processing.- Chapter 10: Important bio-analytical instrumental techniques in pharmacokinetics.- Chapter 11: Statistics in pharmacokinetics.- Chapter 12: Pharmacokinetic software and tools.- Chapter 13: Pharmacokinetic laboratory-based experiments.- Chapter 14: Pharmacokinetic numerical problems with solutions.- Chapter 15: Questions, and questions & answers for practice.
£54.99
Nova Science Publishers Inc Advances in Medicinal Chemistry Research
Book SynopsisAdvances in Medicinal Chemistry Research is a book addressed to undergraduate and postgraduate students, where recent advances in the discovery and development of effective agents against the most remarkable wide-reaching diseases are presented, divided into seven chapters. This first edition of Advances in Medicinal Chemistry Research offers insights into medicinal chemistry that arguably have the most significant impact on our lives than any other. It draws together research on therapeutic agents from natural, synthetic, and virtual screening sources as starting points for the design of drugs against obesity, multidrug-resistant bacteria, neglected tropical diseases, Alzheimer, and cancer. From the prediction of promising hits and identification of active compounds to the extraction of more complex molecules, this book explores a range of essential topics to support the development of novel, economical, and efficacious therapeutics for these diseases, which currently affect a billion people worldwide. Beginning with an overview of obesity, showing the current research landscape, the books shows the importance of natural and synthetic products as promising anti-obesity agents. Subsequently, the medicinal chemistry of modulation of bacterial resistance is presented, focusing on the MFS, RND, ABC, and MATE superfamilies. The book goes on to discuss such topics as antituberculosis, antileishmanial, and anti-hepatitis thiophene-containing compounds, under the medicinal chemistry point of view. Also, potent human glutaminyl cyclase inhibitors are deeply discussed and displayed as hopeful anti-Alzheimer's agents. The last three chapters are focused on the development of researches involving new anticancer agents, initializing with LBDD, SBDD, QSAR, and QM/MM methods applied to the identification of novel promising anticancer compounds. Moreover, IDO1 inhibitors are exhaustively explored and analyzed as a new promise for the immunotherapy of cancer. Finally, a great update on Eg5 kinesin inhibitors is provided, exploring different chemical classes of synthetic and natural compounds, including miscellanea as a new approach for Eg5 inhibition. Combining the expertise of researchers from around the world, this volume aims to support and encourage researches for the development of novel, safe, and active agents against lipase enzyme, bacteria, neglected tropical diseases, Alzheimer, and cancer. The clear narrative truly engages the reader, holding their attention right from the opening of a chapter, and maintaining interest and understanding as a chapter leads into more complex material. Advances in Medicinal Chemistry Research is a book that reviews ongoing developments and recent cutting-edge advances in medicinal chemistry of the most relevant diseases found nowadays, underlining how medicinal chemistry research continues to make significant contributions to the discovery and development of new therapeutic entities. Key Features Chapters written by active specialists and leading experts deeply engaged in the research field of most deadly and limiting diseases for drug discovery. Draws together cutting-edge research advances in medicinal chemistry focused at the obesity, multidrug-resistant microorganisms, Alzheimer, and cancer in a single volume. Highlights the future potential of researches for the medicinal chemistry of most impactful diseases today. Contents addressed to medicinal chemistry, biochemistry, biology, and pharmacy students, professors, and researchers.
£138.39
Nova Science Publishers Inc Antimicrobial Resistance: Opportunities and
Book SynopsisThis book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms. The book intends to provide a state-of-the-art collection of reviews and methods for both basic and clinician investigators who are interested in multidrug resistance mechanisms and reversal strategies. We believe that this information will be of value to clinicians, epidemiologists, microbiologists, virologists, parasitologists, public health authorities, medical students, and fellows in training. Each chapter begins with a summary of the concepts, so that those not actively working in the field can readily gain an overall picture of what follows. The book contains 13 chapters which deal with the antibiotic resistance mechanism in bacteria, fungus, virus and also methicillin resistance S.aureus. The book also explains the futuristic strategy to deal with the antibiotic resistance. We have endeavoured to provide this information in a style that is accessible to the broad community of persons who are concerned with the impact of drug resistance in our clinics and across broader global communities.Table of ContentsPreface; History of Drug-Resistant Microbes; Mechanism of Antibiotic Resistance in Bacteria; Infectious Pathogens, Pathogenesis, Antimicrobial Therapy, Antimicrobial Resistance, and Surveillance Measures; Fungal Resistance to Antibiotics; Antibiotic Resistance and Tolerance in Bacterial Biofilm; Methicillin Resistant Staphylococcus aureus (MRSA): An Overview; Mechanism of Drug Resistance in Mycobacterium tuberculosis; Viral Drug Resistance; Strategies for Circumventing Antimicrobial Resistance; Metallic Nanoparticles in Tackling of Antimicrobial Resistance; Plant Antimicrobials: An Alternative for Overcoming Microbial Resistance; Algae: Novel Cell Factories for Antimicrobial Compounds to Overcome Antibiotic Resistance; Microbial Resistance: A Worldwide Public Health Problem; Index.
£163.19
Springer Intestinal Lipid Metabolism
a huge range and FREE tracked UK delivery on ALL orders.
£170.99
Springer DNA Topoisomerases in Cancer Therapy Present and Future
a huge range and FREE tracked UK delivery on ALL orders.
£85.49
Springer Cardiovascular Research
a huge range and FREE tracked UK delivery on ALL orders.
£109.99
