Biotechnology Books

William J. Thieman taught biology at Ventura College for 40 years and biotechnology for 11 years before retiring from full time teaching in 2005. He continues to serve as an advisor to the college biotechnology program. He received his B.A. in biology from California State University at Northridge in 1966 and his M.A. degree in Zoology in 1969 at UCLA. In 1995, he started the biotechnology program at Ventura College. In 1998, he added the laboratory skills course, and it was articulated as a state-approved vocational program. He identified technical skills needed for the program while serving three summer internships at Amgen, Biosource (now Invotrogen) and Biopool. The internships provided an opportunity to learn protocols, interact with lab directors, and query technicians, focusing on identifying the skills needed in these biotechnology companies. He routinely engaged his contacts at these biotechnology companies to lead lab protocols and describe their experienc

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Book SynopsisMicrofluidic technology is revolutionising a number of scientific fields, including chemistry, biology, diagnostics, and engineering. The ability to manipulate fluids and objects within networks of micrometre-scale channels allows reductions in processing and analysis times, reagent and sample consumption, and waste production, whilst allowing fine control and monitoring of chemical or biological processes. The integration of multiple components and processes enable “lab-on-a-chip” devices and “micro total analysis systems” that have applications ranging from analytical chemistry, organic synthesis, and clinical diagnostics to cell biology and tissue engineering. This concise, easy-to-read book is perfectly suited for instructing newcomers on the most relevant and important aspects of this exciting and dynamic field, particularly undergraduate and postgraduate students embarking on new studies, or for those simply interested in learning about this widely applicable technology. Written by a team with more than 20 years of experience in microfluidics research and teaching, the book covers a range of topics and techniques including fundamentals (e.g. scaling laws and flow effects), microfabrication and materials, standard operations (e.g. flow control, detection methods) and applications. Furthermore, it includes questions and answers that provide for the needs of students and teachers in the area.Table of ContentsTheory of Microfluidics; Device Fabrication; Layout of Microfluidic Chips; Engineering Surfaces; Forces in Microfluidics; Flow Control; Valving and Pumping; Mixing; Droplet Formation and Manipulation; Extraction and Reactions; Separations on Chip; Optical Detection; Electrochemistry; Cells in Lab on a Chip; Development of a Lab-on-a-Chip Systems for Point-of-care Applications

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Book SynopsisWhat existential threats does humanity face? And how can we secure our future? ‘The Precipice is a powerful book . . . Ord’s love for humanity and hope for its future is infectious’ Spectator ‘Ord’s analysis of the science is exemplary . . . Thrillingly written’ Sunday Times We live during the most important era of human history. In the twentieth century, we developed the means to destroy ourselves – without developing the moral framework to ensure we won't. This is the Precipice, and how we respond to it will be the most crucial decision of our time. Oxford moral philosopher Toby Ord explores the risks to humanity's future, from the familiar man-made threats of climate change and nuclear war, to the potentially greater, more unfamiliar threats from engineered pandemics and advanced artificial intelligence. With clear and rigorous thinking, Ord calculates the various risk levels, and shows how our own time fits within the larger story of human history. We can say with certainty that the novel coronavirus does not pose such a risk. But could the next pandemic? And what can we do, in our present moment, to face the risks head on? A major work that brings together the disciplines of physics, biology, earth and computer science, history, anthropology, statistics, international relations, political science and moral philosophy, The Precipice is a call for a new understanding of our age: a major reorientation in the way we see the world, our history, and the role we play in it.Trade ReviewToby Ord is today’s Carl Sagan. Clear and inspiring, this book leaves us hopeful for a flourishing human future -- Christine Peterson, co-founder of the Foresight InstituteA powerfully argued book that alerts us to what is perhaps the most important – and yet also most neglected – problem we will ever face -- Peter Singer, author of 'Animal Liberation' and 'The Life You Can Save'The Precipice separates science from hype and will remain the definitive work on existential risk for a long time to come -- Max Tegmark, author of 'Life 3.0' and 'Our Mathematical Universe'A fascinating and persuasive guide to the most important topic of all: how our species will survive the risks we pose to our continued existence -- Stuart Russell, author of 'Human Compatible' and 'Artificial Intelligence: A Modern Approach'This book is a wake-up call to the existential threats of nuclear and biological weapons and the urgent need for action. A must-read that galvanises us to play a role in addressing these risks -- Angela Kane, former UN High Representative for Disarmament AffairsHumanity has never been more vulnerable – there’s now a one-in-six chance that civilisation won’t make it to the end of the century, argues a highly influential philosopher . . . Ord’s analysis of the science is exemplary . . . Thrillingly written * Sunday Times *Many people have recently found that they want to read books offering the grandest perspectives possible on human existence, such as Sapiens . . . Toby Ord’s new book is a startling and rigorous contribution to this genre that deserves to be just as widely read * Evening Standard *Splendid . . . The Precipice is a powerful book, written with a philosopher’s eye . . . Ord’s love for humanity and hope for its future is infectious * Spectator *Urgent and vaguely prophetic . . . In a year in which our everyday lives were upended by the unexpected (or rather the expected yet neglected), The Precipice is a good way to put everything in perspective -- Books of the Year * WIRED *The Precipice is a fascinating book, one that showcases both the knowledge of its author and his humanity * Axios *A book that seems made for the present moment * New Yorker *A story of the greatest risks to humanity’s future, from the climate crisis and nuclear war to pandemics and artificial intelligence -- Highlights for 2020 * Guardian *

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Book SynopsisToday's synthetic biologists are in the early stages of engineering living cells to help treat diseases, sense toxic compounds in the environment, and produce valuable drugs. With this manual, you can be part of it.

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Book SynopsisBiotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs, Second Edition addresses the pivotal issues relating to translational science, including preclinical and clinical drug development, regulatory science, pharmaco-economics and cost-effectiveness considerations. The new edition also provides an update on new proteins and genetic medicines, the translational and integrated sciences that continue to fuel the innovations in medicine, as well as the new areas of therapeutic development including cancer vaccines, stem cell therapeutics, and cell-based therapies.Trade Review“Overall, this book provides a valuable resource that can be utilized as a quick look-up guide and, more importantly, as an educational tool that can be used in strategic planning. The presentation style provides comprehensive information amenable to a diverse audience.” (Clinical Infectious Diseases, 30 October 2014)Table of ContentsContributors xiii Foreword xv Preface xvii Preface to the First Edition xix Acknowledgments xxi Organization of the Book xxiii User Agreement xxv Part I Transforming Proteins and Genes into Drugs—The Science and the Art 1 1 Introduction to Biopharmaceuticals 3 Abstract 3 1.1 Background and Significance 4 1.2 Translation of Biotechnology for Developing Biopharmaceuticals 7 1.3 Historical Perspective of Pharmaceutical Biotechnology 8 1.4 Distinctions between Chemical Drugs Versus Biopharmaceuticals 8 1.5 Summary 10 2 Distinctions of Biologic Versus Small Molecule Platforms in Drug Development 13 Abstract 13 2.1 Introduction 14 2.2 Transforming New Molecules into Drugs: The Drug Development Process 14 2.3 Key Differences between Biotechnology and Chemical Products 16 2.4 Current Trends in Drug Development 18 2.5 Summary 22 3 Financing Biologic Drug Development 23 Abstract 23 3.1 Introduction 24 3.2 The Role of the Orphan Drug Act 27 3.3 Clinical Leverage Strategy in Accelerating Drug Development 30 3.4 Therapeutic Target Considerations 32 3.5 Evolving Trends 34 3.6 Summary 36 4 Application of Biotechnology in Drug Discovery and Early Development 39 Abstract 39 4.1 Introduction 40 4.2 Data Mining, Molecular Cloning, and Characterization 40 4.3 Optimization of Cell Expression Systems and Product Yield 50 4.4 Molecular Optimization 51 4.5 Proteins and Genes as Targets for Drug Discovery and Development 56 4.6 Summary 58 5 Large-Scale Production of Recombinant Proteins 63 Abstract 63 5.1 Introduction 64 5.2 Yield Optimization in Genetic Constructs and Host Cells 65 5.3 Large-Scale Cultivation of Host Cells 66 5.4 Downstream Processing and Purification 70 5.5 Quality Assurance and Quality Control 75 5.6 Summary 77 6 Clinical Pharmacology, Toxicology, and Therapeutic Dosage and Response 79 Abstract 79 6.1 Introduction 80 6.2 Clinical Pharmacology and Toxicology 80 6.3 Dose and Therapeutic Response 95 6.4 Dosage Form and Route of Administration 97 6.5 Summary 99 7 Clinical Evaluation and Regulatory Approval and Enforcement of Biopharmaceuticals 103 Abstract 103 7.1 Introduction: Biologic Drug Development and Approval 104 7.2 Licensing of Biological Products 104 7.3 Preclinical and Clinical Testing 107 7.4 FDA Review and Approval Process 114 7.5 Regulatory Enforcement 118 7.6 Globalization of Drug Approval (Chien*) 118 7.7 Summary 122 8 Pharmacoeconomics and Drug Pricing (Garrison*) 125 Abstract 125 8.1 Introduction: Pharmacoeconomics 126 8.2 Cost-Effectiveness: Assessing the Value of Biopharmaceuticals 126 8.3 The Cost of Developing Biopharmaceuticals 128 8.4 Pricing Biopharmaceuticals 131 8.5 Drug Development Incentives 133 8.6 Economics of Biosimilars 133 8.7 Economic Impact of Personalized Medicine 134 8.8 Summary and Future Challenges 135 Part II Therapeutic and Clinical Applications of Biopharmaceu ticals—Proteins and Nucleic Acids 137 9 Antibodies and Derivatives 139 Abstract 139 Section One 140 9.1 Molecular Characteristics and Therapeutic Applications 140 9.1.1 Introduction 140 9.1.2 Historical Perspective—Discovery, Classification, Biodistribution, and Physiological Characteristics of Antibody Molecules 140 9.1.3 Gamma Globulin and Hyperimmune Globulin 144 9.1.4 Monoclonal Antibodies—From Mouse, Mouse-Human Chimeric, Humanized, to Human Monoclonal Antibodies 145 9.1.5 Antibody Derivatives 147 9.1.6 Disposition of Antibodies 149 9.1.7 Extravascular Tissue Penetration 155 9.1.8 Mechanisms of Antibody Bioactivities 156 9.1.9 Antibody Conjugates 156 9.1.10 Antibodies and Derivatives in Development 158 9.1.11 Summary 159 Section Two 162 9.2 Antibodies and Derivatives Monographs List 162 9.3 Antibodies and Derivatives Monographs 163 10 Hematopoietic Growth and Coagulation Factors 211 Abstract 211 Section One 212 10.1 Molecular Characteristics and Therapeutic Applications 212 10.1.1 Introduction 212 10.1.2 Hematopoietic Growth and Coagulation Factors 212 10.1.3 Therapeutic Use of Hematopoietic Growth Factors (Molineux, Elliott*) 218 10.1.4 Therapeutic Use of Coagulation and Anticoagulation Factors 225 10.1.5 Summary 229 Section Two 231 10.2 Hematopoietic Growth and Coagulation Factors List 231 10.3 Hematopoietic Growth and Coagulation Factors Monographs 231 11 Cytokines and Interferons 251 Abstract 251 Section One 252 11.1 Molecular Characteristics and Therapeutic Applications 252 11.1.1 Introduction 252 11.1.2 Interleukins as Immunotherapeutics 252 11.1.3 Interferon Biology and Cancer Therapy (Tiu, Koon, Borden*) 256 11.1.4 Interferons as Antiviral Therapy 271 11.1.5 Interferons in Multiple Sclerosis 275 11.1.6 Summary 280 Section Two 288 11.2 Cytokines and Interferons Monographs List 288 11.3 Cytokines and Interferons Monographs 288 12 Hormones 307 Abstract 307 Section One 308 12.1 Molecular Characteristics and Therapeutic Applications 308 12.1.1 Introduction 308 12.1.2 Peptide Hormones and Clinical Significance 308 12.1.3 Therapeutic Application of Recombinant and Synthetic Hormones 309 12.1.4 Summary 318 Section Two 320 12.2 Hormones Monographs List 320 12.3 Hormones Monographs 320 13 Enzymes 357 Abstract 357 Section One 358 13.1 Molecular Characteristics and Therapeutic Applications 358 13.1.1 Introduction 358 13.1.2 Enzyme Replacement Therapy 359 13.1.3 Enzymes as Therapeutic Agents 365 13.1.4 Summary and Future Prospects 368 Section Two 370 13.2 Enzymes Monographs List 370 13.3 Enzymes Monographs 370 14 Vaccines (Hu, Ho*) 389 Abstract 389 Section One 390 14.1 Molecular Characteristics and Therapeutic Applications 390 14.1.1 Vaccines and Their Impact on Human Health 390 14.1.2 How Vaccines Work: Interplay among Immune System, Diseases, and Vaccines 393 14.1.3 Traditional Vaccine Approaches 394 14.1.4 Subcellular and Recombinant Subunit Vaccines 395 14.1.5 Vaccine Adjuvants 398 14.1.6 Mode and Route of Vaccine Delivery 400 14.1.7 Future Directions 403 14.1.8 Summary 405 Section Two 409 14.2 Vaccines Monographs List 409 14.3 Vaccines Monographs 409 15 Other Biopharmaceutical Products 417 Abstract 417 15.1 Other Biopharmaceutical Products Monographs List 418 15.2 Other Biopharmaceutical Products Monographs 418 Part III Future Directions 425 16 Advanced Drug Delivery 427 Abstract 427 16.1 Introduction 428 16.2 Drug Therapeutic Index and Clinical Impact 429 16.3 Routes of Therapeutic Protein Administration 430 16.4 Physiological and Mechanistic Approaches 436 16.5 Approaches Using Devices 458 16.6 Molecular Approaches 460 16.7 Summary 465 17 Advances in Personalized Medicine: Pharmacogenetics in Drug Therapy 471 Abstract 471 17.1 Introduction to Interindividual Variation 472 17.2 Historical Perspective on Pharmacogenetics in Drug Safety and Efficacy 473 17.3 Pharmacogenetics in Drug Disposition and Pharmacokinetics 478 17.4 Pharmacogenetics in Drug Effects and Pharmacodynamics 483 17.5 Individualized Gene-Based Medicine: A Mixed Blessing 487 17.6 Current and Future Prospects of Pharmacogenetics 490 17.7 Summary 492 18 Gene and Cell Therapy 495 Abstract 495 18.1 Overview 496 18.2 General Strategies in Gene and Cell Therapy 499 18.3 Gene and Cell Therapy for Select Medical Conditions 501 18.4 Gene Therapy Research, Development, and Clinical Use (Sullivan*) 506 18.5 Stem Cells in Regenerative Medicine and Diagnostics (Kelly*) 509 18.6 Summary 513 19 Integration of Discovery and Development: The Role of Genomics, Proteomics, and Metabolomics 517 Abstract 517 19.1 Overview 518 19.2 Integration of Discovery and Development of Therapeutic Candidates 520 19.3 Genomics: The First Link between Sequences and Drug Targets 521 19.4 Proteomics: From Sequences to Functions 524 19.5 Metabolomics: Metabolic Profile Elucidation 528 19.6 Integrating Genomic, Proteomic, and Metabolomic Tools to Accelerate Drug Development 530 19.7 Summary 532 20 Pharmacoeconomics, Outcome, and Health Technology Assessment Research in Drug Development 535 Abstract 535 20.1 Introduction: Health-Care Decisions and Health Outcomes 536 20.2 Integration of Pharmacoeconomic Outcome Research in Clinical Drug Development 538 20.3 Regional Differences in the Type of Evidence and Value Data Essential for Health-Care and Reimbursement Decisions 541 20.4 Biopharmaceutical Company Strategies 542 20.5 Summary 545 20.6 Acknowledgments 546 21 Future Prospects 547 Abstract 547 21.1 Progress and Benefits in Transforming Proteins and Genes into Biopharmaceuticals 548 21.2 Genomic Information Improves Safety and Production Cost of Biopharmaceuticals 548 21.3 The Business of Biopharmaceuticals and Economic Impacts 549 21.4 Influence of Biopharmaceuticals on Pharmaceutical Research, Development, and the Drug Industry 549 21.5 Public–Private Partnership in Financial and Regulatory Support to Improve Translational Success 550 21.6 Biopharmaceuticals and Public Health Benefits 551 21.7 Public Participation and Influence on Biopharmaceutical Development 551 21.8 Outlook 552 Appendix I. Dosage Form, Pharmacokinetics, and Disposition Data 555 Appendix II. Molecular Characteristics and Therapeutic Use 581 Appendix III. Nomenclature of Biotechnology Products 617 Appendix IV. Other Information 621 Index 633 Color plate section is located between pages 210 and 211.

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Book SynopsisGrossly ambitious and rooted in scientific scholarship, The Other Dark Matter shows how human excrement can be a life-saving, money-making resource—if we make better use of it.Trade Review"A take on waste that's anything but wasteful—it's a fascinating dig into the history and science of handling human excrement. . . . Equally remarkable are Zeldovich's sections on the development and evolution of wastewater treatment plants. . . . Zeldovich is at home with an awkward subject, making for a grossly engrossing and vivid survey. Readers won't take the 'flush and forget' mindset for granted again." * Publishers Weekly *"Zeldovich is an engaging writer. She loves puns and poop jokes. (Who doesn't?) And her travels around the world are, in their own scatological way, inspiring." -- Elizabeth Kolbert * New York Review of Books *"[An] original, necessary book." * Nature *"It would be easy for a book that focuses on obstacles to improving global sanitation, fixing the agricultural waste cycle, reducing pollution, and improving health to resort to paralyzing gloom. The Other Dark Matter does not shy from the enormity of the problems, yet suggests solutions are achievable, at scales from individuals to entire countries. Paced quickly with prose enlivened by the author's on-location reporting and personal experiences, the book is far from a grim slog through the world's sewers—it's more like an exciting tour in a biogas-powered balloon." * Undark *"The Other Dark Matter does not shy from the enormity of the problems, yet suggests solutions are achievable, at scales from individuals to entire countries. Paced quickly with prose enlivened by the author's on-location reporting and personal experiences, the book is far from a grim slog through the world's sewers — it's more like an exciting tour in a biogas-powered balloon." * Salon *"It's unusual to come across a book that makes you say, 'Oh, crap!' in a good way." * American Scientist *“In bright and airy prose, she takes readers on a globe-spanning trip to sites where fecal material is reprocessed and figuratively turned into gold. . . . Readers should leave this book with a renewed interest in sustainable systems to manage what we normally put out of sight and out of mind." * Natural History *“It is unquestionably [a topic] that—given the ever-increasing human population belaboring the planet—merits our attention if we are, ecologically and sustainably speaking, to prevent finding ourselves collectively up a famous creek without a propulsion device. Ms. Zeldovich’s new book looks to be an excellent way to introduce ourselves to it.” * The Well-Read Naturalist *"Given the growing scale of public engagement in sanitation, there is a glut of books on the subject. Not all of them are readable, not all of them are well researched. This one is. It takes the technology questions further. It is an engaging read on a queasy topic" * Shaastra *"In writing a primer on poop and its possibilities, [Zeldovich] performs a much larger function: destigmatizing a vital biological product that has long gotten a bum rap." * Columbia Magazine *"Some of the ideas in [the book] really feel like they could change the world in a major way. . . . It's really excellent." * Across the Margin *"Even readers familiar with the history and ecology of waste management will not be disappointed. . . . As detailed as it is witty. . . . Given the growing scale of public engagement in sanitation, there is a glut of books on the subject. Not all of them are readable, not all of them are well researched. This one is. It takes the technology questions further. It is an engaging read on a queasy topic." * Shaastra *"This is some good shit, people. Not only entertaining, but deeply important. Everyone with a colon should read this book. Centuries back, people knew the value of shit. In countries with poor soil, human waste was like gold: people stole it, paid their rent with it, and gave it as gifts. Today, keeping it out of our waterways is our best hope for defusing what Zeldovich calls the Great Sewage Time Bomb. She is an ideal guide to this ridiculously fascinating world." -- Mary Roach, author of Stiff: The Curious Lives of Human Cadavers"Zeldovich shows to dazzling effect how a famously difficult subject—the often peculiar scientific history of human waste—can become an engrossing tale. The story is enlightening, surprising, occasionally enraging—and wholly worth your time." -- Deborah Blum, Pulitzer Prize–winning author of The Poison Squad"Zeldovich shows that excrement can be useful, profitable, and anything but waste, and does this with warmth, curiosity, and humor. This book is a great companion should you wish to journey to the rich and still underexposed world of shit (and you should)." -- Rose George, author of The Big Necessity: The Unmentionable World of Human Waste and Why It Matters"Here is an indispensable book about what we might call the Anthro-poo-cene. Humanity's current collision course with nature has everything to do with energy and how we abuse it—including the human waste products of our metabolic bodies. This lively and entertaining history is also full of innovative ways people are finally dealing with their you-know-what." -- Mary Ellen Hannibal, author of Citizen Scientist: Searching for Heroes and Hope in an Age of Extinction"Who knew our poop could be so fascinating and important? In her brilliantly reported and written new book, Zeldovich shows that now more than ever the health of humanity and the rest of nature depends on how we handle 'the other dark matter.'" -- John Horgan, author of Pay Attention: Sex, Death, and Science"An intriguing, compelling, very human story of how a valuable resource has been used and squandered, thrown away, and rediscovered. It is a story of the people who, against a background of mockery and disbelief, have developed creative, lucrative, and ecologically viable options for reframing what many have seen as a 'problem' of 'waste disposal' into an opportunity for innovative resource use. It will have wide appeal to all intelligent readers, both within and well beyond academia." -- David Waltner-Toews, author of The Origin of Feces: What Excrement Tells Us About Evolution, Ecology, and a Sustainable SocietyTable of ContentsPart 1: The History of Human Waste Chapter 1: How I Learned to Love the Excrement Chapter 2: The Early History of Human Excreta Chapter 3: Treasure Night Soil as if It Were Gold! Chapter 4: The Water Closet Dilemma and the Sewage Farm Paradigm Chapter 5: Germs, Fertilizer, and the Poop Police Part 2: The Present: A Sludge Revolution in Progress Chapter 6: The Great Sewage Time Bomb and the Redistribution of Nutrients on the Planet Chapter 7: Loowatt, a Loo That Turns Waste into Watts Chapter 8: The Crap That Cooks Your Dinner and Container-Based Sanitation Chapter 9: HomeBiogas: Your Personal Digester in a Box Chapter 10: Made in New York Chapter 11: Lystek, the Home of Sewage Smoothies Chapter 12: How DC Water Makes Biosolids BLOOM Chapter 13: From Biosolids to Biofuels Part 3: The Future of Medicine and Other Things Chapter 14: Poop: The Best (and Cheapest) Medicine Chapter 15: Looking where the Sun Doesn’t Shine Chapter 16: From the Kindness of One’s Gut: An Insider Look into Stool Banks Afterword: Breathing Poetry into Poop Notes Index

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Book SynopsisThe 'bioeconomy' is the idea of an economy based on the sustainable exploitation of biological resources. Within this concept, there is increasing emphasis on issues such as climate change, depletion of natural resources and growing world food needs. The bioeconomy builds on the recognition of advances in technology, particularly in the life sciences, but at the same time covers issues such as innovation management, ecosystem services, development and governance. This book explores the development of the bioeconomy across the world from an economic and policy perspective, as well as identifying potential future pathways and issues. It uses a broad definition, covering all sectors using biological resources except health, and rather than focusing on individual sectors, it explores the breadth of interconnections that make the bioeconomy a new and challenging subject. Divided into two parts, the book initially outlines the current definitions, strategies, policy and economic information related to the world's bioeconomy. The second part describes current economic analysis and research efforts in qualifying and understanding the economics of the bioeconomy. This includes the contributions of technology, research and innovation; driving forces and demand-side economics; supply-side economics, and the role of markets and public policy in matching demand and supply. The political economy, regulation and transitions are considered, as well as the contribution of the bioeconomy to society, including growth, development and sustainability. Key features include: - An analysis of varied international approaches to the bioeconomy. - A joint consideration of biotechnology, agriculture, food energy and bio-materials. - An assessment of sustainability in the bioeconomy. - A comprehensive view of the issues from an economic and policy perspective. This book will be of interest to students and researchers in agricultural and natural resource economics, agricultural and environmental policy, as well as policy-makers, practitioners and economists.Table of Contents1: Introduction and Overview 2: What is the Bioeconomy 3: Technology and Innovation in the Bioeconomy 4: Approaches to (the Economics of) the Bioeconomy 5: Driving Forces and Demand-side Economics 6: Supply-side Economics 7: Matching Demand and Supply: Markets, Policies and Beyond 8: The Political Economy of the Bioeconomy, Regulation, Public Policy and Transition 9: The Bioeconomy and Sustainable Development 10: Impact Evaluation and Management Tools 11: At the Boundary of Economics 12: Final Thoughts and Outlook

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Book Synopsis"Many artists seek to attain immortality through their art, but few would expect their work to outlast the human race and live on for billions of years. As Canadian poet Christian Bök has realized, it all comes down to the durability of your materials."—The Guardian Internationally best-selling poet Christian Bök has spent more than ten years writing what promises to be the first example of "living poetry." After successfully demonstrating his concept in a colony of E. coli, Bök is on the verge of enciphering a beautiful, anomalous poem into the genome of an unkillable bacterium (Deinococcus radiodurans), which can, in turn, "read" his text, responding to it by manufacturing a viable, benign protein, whose sequence of amino acids enciphers yet another poem. The engineered organism might conceivably serve as a post-apocalyptic archive, capable of outlasting our civilization. Book I of The Xenotext constitutes a kind of "demonic grimoire," providing a scientific framework for the project with a series of poems, texts, and illustrations. A Virgilian welcome to the Inferno, Book I is the "orphic" volume in a diptych, addressing the pastoral heritage of poets, who have sought to supplant nature in both beauty and terror. The book sets the conceptual groundwork for the second volume, which will document the experiment itself. The Xenotext is experimental poetry in the truest sense of the term. Christian Bök is the author of Crystallography (1994) and Eunoia (2001), which won the Griffin Poetry Prize. He teaches at the University of Calgary in Alberta, Canada.Table of Contents1. The Late Heavy Bombardment A long poem about the hellish origins of life on Earth—a series of bombastic firebombs that crescendo, then go quiet: a Virgilian welcome to the Inferno. 2. The March of the Nucleotides A series of poems and texts, which introduce readers to the basics of genetics, with some pastoral material that illustrates many of the thematic premises for the book. 3. Colony Collapse Disorder A long, dark poem that translates Book IV of The Georgics by Virgil—(a “pastoral nocturne,” providing a pretense for retelling the myth of Orpheus and Eurydice). 4. The Virelay of the Amino Acids A long, love poem, whose repetitious incantation emulates and embodies the molecular structure of each of the amino acids (the building materials of life). 5. Alpha Helix A long poem that constitutes a kind of paranoiac catalogue of instances, where helices appear in the most quotidian phenomena, imbuing everything with life.

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Book SynopsisComputational Chemistry Methodology in Structural Biology and Materials Sciences provides a selection of new research in theoretical and experimental chemistry, focusing on topics in the materials science and biological activity. Part 1, on Computational Chemistry Methodology in Biological Activity, of the book emphasizes presents new developments in the domain of theoretical and computational chemistry and its applications to bioactive molecules. It looks at various aspects of density functional theory and other issues. Part 2, on Computational Chemistry Methodology in Materials Science, presents informative new research on computational chemistry as applied to materials science. The wide range of topics regarding the application of theoretical and experimental chemistry and materials science and biological domain will be valuable in the context of addressing contemporary research problems. Table of ContentsStudy of pKa Values of Alkylamines Based on Density Functional Theory. A DFT Investigation of the Influence of Α, Β Unsaturation in Chemical Reactivity of Coumarin and Some Hydroxy Coumarins. Molecular Determinants of TRPC6 Channel Recognition by FKBP12. In Silico Design of PDHK Inhibitors: From Small Molecules to Large Fluorinated Compounds. The Smart Cyberinfrastructure: Space-Time Multiscale Approaches for Research and Technology. Application of Computational Methods to the Rational Design of Photoactive Materials for Solar Cells. Theoretical Studies on Adsorption of Organic Molecules on Metal Surface. A Comparative Theoretical Investigation on the Activation of C-H Bond in Methane on Mono and Bimetallic Pd and Pt Subnanoclusters. Theoretical Analysis: Electronic and Optical Properties of Small Cu-Ag Nano Alloy Clusters. Multisolitons in SRR Based Metamaterials in Klein-Gordon Lattice. Ab-Initio Techniques for Light Matter Interaction at the Nanoscale. Synthesis and Characterization of Multi-Component Nanocrystalline High Entropy Alloy.

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Book SynopsisNATIONAL BESTSELLER • The gripping story of Elizabeth Holmes and Theranos—one of the biggest corporate frauds in history—a tale of ambition and hubris set amid the bold promises of Silicon Valley, rigorously reported by the prize-winning journalist. With a new Afterword covering her trial and sentencing, bringing the story to a close.“Chilling ... Reads like a thriller ... Carreyrou tells [the Theranos story] virtually to perfection.” —The New York Times Book ReviewIn 2014, Theranos founder and CEO Elizabeth Holmes was widely seen as the next Steve Jobs: a brilliant Stanford dropout whose startup “unicorn” promised to revolutionize the medical industry with its breakthrough device, which performed the whole range of laboratory tests from a single drop of blood. Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at more than $9 billion, putting Holmes’s worth at an estimated $4.5 billion. There was just one problem: The technology didn’t work. Erroneous results put patients in danger, leading to misdiagnoses and unnecessary treatments. All the while, Holmes and her partner, Sunny Balwani, worked to silence anyone who voiced misgivings—from journalists to their own employees.

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Book SynopsisTable of ContentsPart 1: Materials Science and Engineering Section 1.2 Properties of Materials Section 1.3 Classes of Materials Used in Medicine Section 1.4: Materials Processing Part 2: Biology and Medicine Section 2.1 Some Background Concepts Section 2.2 Host Reaction to Biomaterials and Their Evaluation Section 2.3 Characterization of Biomaterials Section 2.4 Degradation of Materials in the Biological Environment Section 2.5 Applications of Biomaterials Section 2.6 Applications of Biomaterials in Functional Tissue Engineering Part 3: The Medical Product Life Cycle Appendix A: Properties of Biological Fluids Appendix B: Properties of Soft Materials Appendix C: Chemical Composition of Metals and Ceramics Used for Implants Appendix D: The Biomaterials Literature Appendix E: Assessment of Cell and Matrix Components in Tissues (Online only)

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Book SynopsisTable of ContentsUnit I – The cell 1. An introduction to biotechnology 2. Voyage into the cell 3. Proteins 4. Genes: the blueprints for proteins 5. Cell growth Unit II – Biotechnology in the laboratory 6. Microbial killing 7. Cell culture and the eukaryotic cells used in biotechnology 8. Fluorescence 9. Agarose gels 10. The polymerase chain reaction (PCR) 11. Genetic engineering Unit III – Biotechnology in the real world 12. Gene delivery 13. RNAi 14. Genome editing 15. DNA fingerprinting 16. Fermentation, beer, and biofuels 17. Stem cells, tissue engineering, and regenerative medicine 18. Transgenics and genetically modified organisms in agriculture 19. Patents and licenses

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Book SynopsisTable of Contents1. Social dimensions and preconditions of digitalization in healthcare: Implications of the COVID-19 syndemic2. Digital Innovation for Healthcare in COVID-19 Pandemic3. A digital health ecosystem for Africa during the Covid-19 pandemic4. Doctor New perspectives on telemedicine for women during the COVID pandemic5. Implementing Virtual Patient Rooming during Telemedicine Visits6. Embracing Digital Technologies In The Healthcare Setting7. Impact of COVID-19 on the Adoption of Digital Pathology8. The COVID-19 pandemic in an interdependent world: Digital health as a tool for equity and gender empowerment9. The Study of the Dilemma on the Control of Covid-19 Spread and Face-To-Face Learning and Its Trade-Off Solutions10. Digital tools for direct and indirect citizen empowerment: The retaliatory response against Covid - 19 in India11. Continuum of Care through Patient Relationship Management Approach in Indian Public Healthcare System' 12. Using Machine Learning Methods to Understand COVID-19 Inpatient Medical Health Records in a US Hospital System13. Geospatial analysis of COVID-19 distribution and its relation to public transportation services14. M-Health System for cardiac and COVID patient monitoring using Body Sensor Networks and Machine Learning15. Pandemic-driven innovations contribute to the development of information-based medicine16. Enabling Healthcare 4.0 Applications Development Through a Middleware Platform17. Healthcare 4.0 Significance and Benefits Affirmed by the COVID-19 Pandemic18. Improving the diagnostic accuracy using Amplification and sequencing of the SARS-CoV-2 genome19. Telecardiology COVID-19 Cryptographic System: Security Reinforcement Through Metaheuristics and Artificial Neural Networks 20. The use of digital technologies in the response to SARS-2 CoV2-19 in the public health sector

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Book SynopsisTable of Contents1. A deep learning approach for the prediction of heart attacks based on data analysis 2. A comparative study on fully convolutional networks—FCN-8, FCN-16, and FCN-32: A case of brain tumor 3. Deep learning applications for disease diagnosis 4. An artificial intelligent cognitive approach for classification and recognition of white blood cells employing deep learning for medical applications 5. Deep learning on medical image analysis on COVID-19 x-ray dataset using an X-Net architecture 6. Early prediction of heart disease using a deep learning approach 7. Machine learning and deep learning algorithms in disease prediction: Future trends for the healthcare system 8. Automatic detection of white matter hyperintensities via mask region-based convolutional neural networks using magnetic resonance images 9. Diagnosing glaucoma with optic disk segmenting and deep learning from color retinal fundus images 10. An artificial intelligence framework to ensure a trade-off between sanitary and economic perspectives during the COVID-19 pandemic 11. Prediction of COVID-19 using machine learning techniques

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Book SynopsisAN INSTANT NEW YORK TIMES BESTSELLERONE OF TIME’S 100 MOST INFLUENTUAL PEOPLE IN ARTIFICIAL INTELLIGENCEThe noted inventor and futurist’s successor to his landmark book The Singularity Is Near explores how technology will transform the human race in the decades to comeSince it was first published in 2005, Ray Kurzweil’s The Singularity Is Near and its vision of an exponential future have spawned a worldwide movement. Kurzweil's predictions about technological advancements have largely come true, with concepts like AI, intelligent machines, and biotechnology now widely familiar to the public.In this entirely new book Ray Kurzweil brings a fresh perspective to advances toward the Singularity—assessing his 1999 prediction that AI will reach human level intelligence by 2029 and examining the exponential growth of technology—that, in the near future, will expand human intelligence a milli

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Book SynopsisWritten primarily for mid-to-upper level undergraduates, this primer will introduce students to topics at the forefront of the subject that are being applied to probe biological problems, or to address the most pressing issues facing society. This primer provides an overview of the challenges and opportunities of applying synthetic biological techniques to mammalian cells, tissues, and organisms.Table of Contents1: Jamie A. Davies: An introduction to mammalian synthetic biology 2: Jamie A. Davies: Special features of mammalian systems 3: Lenny Nelson and Alistair Elfick: Technologies for mammalian synthetic biology 4: Jamie A. Davies: Mammalian synthetic biology as a research tool 5: Jamie Billington, Anna Mastela, and Susan J Rosser.: Teaching mammalian cells to make new, useful things 6: Steven M. Pollard: Synthetic biology, stem cells and regenerative medicine 7: David Obree: The ethics of synthetic biology

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Book SynopsisMicrofluidics is a young and rapidly expanding scientific discipline, which deals with fluids and solutions in miniaturized systems, the so-called lab-on-a-chip systems. It has applications in chemical engineering, pharmaceutics, biotechnology and medicine. As the lab-on-a-chip systems grow in complexity, a proper theoretical understanding becomes increasingly important. The basic idea of the book is to provide a self-contained formulation of the theoretical framework of microfluidics, and at the same time give physical motivation and examples from lab-on-a-chip technology. After three chapters introducing microfluidics, the governing equations for mass, momentum and energy, and some basic flow solutions, the following 14 chapters treat hydraulic resistance/compliance, diffusion/dispersion, time-dependent flow, capillarity, electro- and magneto-hydrodynamics, thermal transport, two-phase flow, complex flow patterns and acousto-fluidics, as well as the new fields of opto- and nano-fluidTrade ReviewAn excellent text, very well written and pedagogically sound. Clear, concise, and complete, it explains the theoretical framework of microfluidics to a broad audience. * Kari Dalnoki-Veress, McMaster University, Hamilton, Ontario *Written in a highly pedagogical style. The reader, whether graduate, undergraduate or researcher will find this book extremely useful. * Patrick Tabeling, ESPCI Paris *The field is rapidly evolving to the point where it will become valuable, and indeed necessary, to do calculations to design real devices. This book offers a prescription for doing this. * David Weitz, Harvard University *Table of Contents1. Basic concepts in microfluidics ; 2. Governing equations ; 3. Basic flow solutions ; 4. Hydraulic resistance and compliance ; 5. Diffusion ; 6. Time-dependent flow ; 7. Capillary effects ; 8. Electrohydrodynamics ; 9. Electroosmosis ; 10. Dielectrophoresis ; 11. Magnetophoresis ; 12. Thermal transfer ; 13. Two-phase flow ; 14. Complex flow patterns ; 15. Acoustofluidics ; 16. Optofluidics ; 17. Nanofluidics ; Appendices

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Book SynopsisScholars and policymakers alike agree that innovation in the biosciences is key to future growth. The field continues to shift and expand, and it is certainly changing the way people live their lives in a variety of ways. With a large share of federal research dollars devoted to the biosciences, the field is just beginning to live up to its billing as a source of innovation, economic productivity and growth. Vast untapped potential to imagine and innovate exists in the biosciences given new tools now widely available. In The Biologist''s Imagination, William Hoffman and Leo Furcht examine the history of innovation in the biosciences, tracing technological innovation from the late eighteenth century to the present and placing special emphasis on how and where technology evolves. Place is often key to innovation, from the early industrial age to the rise of the biotechnology industry in the second half of the twentieth century. The book uses the distinct history of bioinnovation to discuss current trends as they relate to medicine, agriculture, energy, industry, ecosystems, and climate. Fast-moving research fields like genomics, synthetic biology, stem cell research, neuroscience, bioautomation and bioprinting are accelerating these trends. Hoffman and Furcht argue that our system of bioscience innovation is itself in need of innovation. It needs to adapt to the massive changes brought about by converging technologies and the globalization of higher education, workforce skills, and entrepreneurship. The Biologist''s Imagination is both a review of past models for bioscience innovation and a forward-looking, original argument for what future models should take into account.Trade ReviewThis exceptionally well researched and engagingly presented account of the growth of biotechnology in medicine, agriculture, manufacturing and pharmaceutical industries is a veritable tour de force. * Ben Mepham, The Biologist *Table of ContentsIntroduction ; Chapter 1: Ideas, progress, wealth, and the biological revolution ; Chapter 2: Drugs, biomolecules, brains, and the shifting currents of innovation ; Chapter 3: Regional bioinnovation: Reaping the harvest of the local ; and the global ; Chapter 4: Mendel's journey from peas to petabytes ; Chapter 5: Toning up universities for regional growth ; Chapter 6: Splicing and dicing: Property, information, and the DNA of innovation ; Chapter 7: Looking ahead as an industry evolves ; Conclusion ; Chapter endnotes ; Selected bibliography ; Acknowledgements ; Index

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Book SynopsisThe advent of recombinant DNA technology in the 1970s was a key moment in the history of both biotechnology and the commercialization of academic research. This book brings to life the hybrid origin story of biotechnology and ways the academic culture of science has changed in tandem with the early commercialization of recombinant DNA technology.Trade Review"Yi's masterwork is a welcome deep-sequencing of how the double helix, DNA, gave rise to the triple helix-university-industry-government relations at the dawn of modern biotechnology. Yi's story traces how a science department changed the world, for better or for worse, or a bit of both." (Robert Cook-Deegan, Duke University)

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Book SynopsisUsing economic models and empirical analysis, this title examines a range of agricultural and biofuel policy issues with regard to their effects on American agricultural and agrarian insurance markets.

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Book SynopsisTrade ReviewDonna Dickenson's book offers a compelling and overarching framework for interpreting new trends in biomedical science, such as gene biobanks, pharmacogenetics, and the banking of cord blood. It forces the reader to ask whether every new technological advance in medicine truly betters the field-and for whom. -- Sheldon Krimsky, Tufts University Few words have as much ethical clout these days as that of 'choice,' a word that can be construed as the centrality of 'me.' Donna Dickenson's splendid book shows how deeply the 'me' has become embedded in medicine and abetted by the seemingly unchallengeable ethical concept of autonomy. What we have lost is the importance of 'we.' Using personalized medicine as her point of departure, she brilliantly works her way through a range of recent medical developments to show the damage the dominance of 'me' can bring. Her book can help restore the 'us' that has been diminished. -- Daniel Callahan, cofounder and president emeritus of The Hastings Center and author of The Roots of Bioethics: Health, Progress, Technology, Death In this timely book, Dickenson levels trenchant criticism at the poster child of the twenty-first-century biomedical establishment: 'personalized medicine.' Analyzing an impressive array of practices in the new life sciences, she makes a persuasive argument that, as personalized medicine unfolds, market values and individualism are trumping the ideals of public health. This book comes at a critical moment. As we reappraise the social contract of health care, this book helps better direct research and development towards the common good. -- David Winickoff, University of California, Berkeley Donna Dickenson's book is a seminal philosophical examination of the enthusiastic embrace of 'personalized medicine,' questioning easy assumptions about its benefits for patient care and for public health. Dickenson sounds powerful warnings about the extent to which personalized medicine risks confusion with individual self-interest and the devotion of biotechnology for private gain. -- Leslie Francis, University of Utah, co-author of The Patient as Victim and Vector: Bioethics and Infectious Disease Recognizing that there are trade-offs in how we conceptualize medicine as either driven and developed for the common good or specialized for the individual, Dickenson offers an important examination of contemporary medicine and a beautifully written account of what is at stake when the common good is overlooked. Hands down, she is one of the most insightful contributors to law and medicine discourse, and this book is a must-read for everyone concerned about the future of biotechnology. -- Michele B. Goodwin, University of Minnesota, and editor of Baby Markets: Money and the New Politics of Creating Families If you are wondering what to make of personalized medicine's grand claims, let Dickenson be your guide. Turning her keen scientific and political intelligence to biotech visions of individually tailored drugs, consumer gene tests, enhancement technologies, and more, she finds tidbits of hope for improving health care among scads of hype-some of it dangerous. This must-read book makes a powerful case for taming market domination and 'me-centeredness' and for renewing our commitments to public health and the common good. -- Marcy Darnovsky, executive director, Center for Genetics and Society Dickenson's mapping out of this vital fork in the road is valuable. Publishers Weekly This book is filled with clearly explained, hard science, giving equal treatment to the benefits and problems of personalized medicine... I recommend expending the necessary reading effort not only for healthcare workers but for the general public. New York Journal of Books Dickenson's greatest achievement in this book is that she largely succeeds in creating a coherent, compelling narrative across the five disparate case studies and that she does so incorporating insights from a range of domains including sociology, ethics, philosophy, law and biomedicine. -- Michael Morrison New Genetics and SocietyTable of ContentsPreface 1. A Reality Check for Personalized Medicine 2. "Your Genetic Information Should Be Controlled by You": Personalized Genetic Testing 3. Pharmacogenetics: One Patient 4. "Your Birth Day Gift": Banking Cord Blood 5. Enhancement Technologies: Feeling More Like Myself 6. "The Ancient, Useless, Dangerous, and Filthy Rite of Vaccination": Public Health 7. Reclaiming Biotechnology for the Common Good Notes Bibliography Index

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Book SynopsisProgrammable Planet is a grand tour through the world of synthetic biology, telling the stories of the colorful visionaries whose ideas are shaping discoveries. Ted Anton explores the field from its beginning in fighting malaria in Africa to the COVID vaccines and beyond.Trade ReviewProgrammable Planet captures the passion and energy of those at the genesis of the construction of the genetically engineered world. -- Christopher Voigt, Daniel I.C. Wang Professor of Biological Engineering, Massachusetts Institute of TechnologyIf you’ve ever wondered about the promise—and the peril—of synthetic biology and its power to transform life, then Programmable Planet is the book for you. Ted Anton’s exploration of both the history and the future of the ways we engineer life is incisive, engaging, and downright fascinating. -- Deborah Blum, Pulitzer Prize–winning author of The Poison Squad: One Chemist’s Single-Minded Crusade for Food Safety in the Early Twentieth CenturyProgrammable Planet is a thoroughly engaging and enjoyable read. Anton is an expert storyteller who blends the human element with cutting-edge science like a synthetic biologist engineering a novel organism. Timely and at times provocative, the book provides a wonderful grounding for those interested in learning more about synthetic biology’s promise and threat. And we should all be interested in learning more. -- Aoife Brennan, president and chief executive officer, SynlogicIn this rollicking compendium, Anton documents a huge number of ways synthetic biology can be used in practice, embedding these examples in the experiences of the people involved. -- Drew Endy, Stanford UniversityTable of ContentsIntroductionPart I. Beginnings1. A Glass of Absinthe: A Malaria Medicine2. A Radical Philosophy3. Pandora’s Box: The Triumph and Temptation of Gene Editing4. The Silk Road: Directing Evolution5. Wild: Remaking LifePart II. Ripples in the Water6. Rush: Biology-Made Medicines7. New Nature: A Do-It-Yourself Environment8. Hearth and Home9. Fantastic Voyages: Mining and the Military10. The Killers: Viruses as HealersPart III. Bioindustrial Revolution11. Race to a Vaccine12. Global Production: Perils and Profits of a New Science13. The Moirai’s Gift14. To the Planets, and Beyond: Synthetic Biology in Space15. FuturamaAcknowledgmentsTimelineGlossaryFurther ReadingNotesIndex

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