Cytopathology Books

Book SynopsisYou can’t sit still. You don’t like unannounced visitors. You always triple-check if the lights are out. But you also see details that no-one else notices. You’re always coming up with surprising solutions. You can focus intensely for hours at a stretch. Usually without realising it, many people lie somewhere on the spectrum of a neurodivergent condition. We often tend to focus on the many downsides of neurodivergent conditions such as AD(H)D, ASD, dyslexia and OCD. This book takes a different approach by looking in depth at the special talents that go hand in hand with these conditions. Whether you already have a diagnosis or simply feel you’re somewhere on the neuroatypical spectrum, one thing is certain: once you’ve identified your unique talents, you’ll be able to make more focused choices in your life and work. You’ll discover which jobs best showcase your talents, which colleagues complement your personality, and which environments and corporate cultures are right for you.

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Book SynopsisThis classic text sets a standard in this subject by outlining the scientific aspects that underlie pathological processes, relating these to specific organ systems and placing all in a context that the student of medicine or pathology can appreciate, understand and enjoy. The clearly defined and easy-to-follow structure, enhanced by numerous photographs and explanatory line diagrams, focuses on core material without neglecting novel concepts and up-to-the minute detail. A one-stop-shop in pathology, it reflects fully the integration of pathology into clinical teaching whether system or problem-based, and will take the student right through medical school and beyond to postgraduate training.Table of ContentsCELLULAR AND MOLECULAR MECHANISMS OF DISEASE. Pathology and its role in medical science and practice. Cell structure, function and adaptation. Tissue injury and repair. Inflammation and immunology. Clinical genetics. Neoplasia. SYSTEMIC PATHOLOGY. The cardiovascular system. The respiratory system. The lymphoreticular system and bone marrow. The gastrointestinal system. The liver, gallbladder and pancreas. The nervous system and the eye. The locomotor system. The kidneys. The female reproductive system. The breasts. The urinary tract and male reproductive system. The endocrine system. The skin. Infections.

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Book SynopsisThis classic text sets a standard in this subject by outlining the scientific aspects that underlie pathological processes, relating these to specific organ systems and placing all in a context that the student of medicine or pathology can appreciate, understand and enjoy. The clearly defined and easy-to-follow structure, enhanced by numerous photographs and explanatory line diagrams, focuses on core material without neglecting novel concepts and up-to-the minute detail. A one-stop-shop in pathology, it reflects fully the integration of pathology into clinical teaching whether system or problem-based, and will take the student right through medical school and beyond to postgraduate training.Table of ContentsCELLULAR AND MOLECULAR MECHANISMS OF DISEASE. Pathology and its role in medical science and practice. Cell structure, function and adaptation. Tissue injury and repair. Inflammation and immunology. Clinical genetics. Neoplasia. SYSTEMIC PATHOLOGY. The cardiovascular system. The respiratory system. The lymphoreticular system and bone marrow. The gastrointestinal system. The liver, gallbladder and pancreas. The nervous system and the eye. The locomotor system. The kidneys. The female reproductive system. The breasts. The urinary tract and male reproductive system. The endocrine system. The skin. Infections.

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Book Synopsisexcellent, well-organized, and timely.Lester Packer and Enrique Cardenas, University of Southern California, Los Angeles, from the Series PrefaceThe liver is a vital organ that is responsible for a wide range of functions, most of which are essential for survival. The multitude of functions the liver performs makes it vulnerable to a wide range of diseases. Mitochondrial dysfunction plays an important role in many liver diseases including drug-induced liver injury, alcoholic liver disease, and nonalcoholic fatty liver disease. Mitochondria in Liver Disease gathers the most current research regarding the role of mitochondria in the liver and various diseases to which it is susceptible.The book is separated into two sections, the first of which highlights the latest developments in mitochondrial research. It includes cutting-edge topics such as the regulation of mitochondrial respiration using hydrogen sulfide and the regulation of mitochonTable of ContentsOVERVIEW OF MITOCHONDRIA. Metabolism of Superoxide Radical and Hydrogen Peroxide in the Mitochondria. Energy-Redox Axis in Mitochondria: Interconnection of Energy-Transducing Capacity and Redox Status. Signal Transduction Pathways That Regulate Mitochondrial Gene Expression. Transcriptional Regulation of Mitochondrial Biogenesis and Quality Control. Mitochondria in Liver Disease: Regulation of Liver Mitochondrial Function by Hydrogen Sulfide. Impact of Aging and Calorie Restriction on Liver Mitochondria. Drug Delivery to Mitochondria: A Promising Approach for the Treatment of Liver Disease. ROLE OF MITOCHONDRIA IN LIVER DISEASES. Central Role of Mitochondria in Drug-Induced Liver Injury. Role of Autophagy and Mitophagy in Liver Diseases. Mitochondrial Dynamics, Mitophagy and Mitochondrial Spheroids in Drug-Induced Liver Injury. Biomarkers of Mitochondrial Damage in the Liver. Alterations of Mitochondrial DNA in Liver Diseases. Epigenetic Modifications of Mitochondrial DNA in Liver Disease: Focus on Nonalcoholic Fatty Liver Disease. Emerging Role of Mitochondrial Dynamics in Viral Hepatitis. Mitochondrial Dynamics and Liver Metabolism. Role of JNK in Lipotoxicity in the Liver. Mitochondrial Function, Dysfunction, and Adaptation in the Liver during the Development of Diabetes. Mitochondrial Dynamics and Adaptation in Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease. Acid Sphingomyelinase, Mitochondria, and Liver Diseases. Regulation of Liver Metabolism by Sirtuins: Emerging Roles.

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Book SynopsisWhen cells are damaged, as often occurs during trauma and metabolic stress, a highly evolved cell healing process follows that was designed to enhance cell survival or remove irreparably injured cells. Following injury, cells attempt to seal breaks in their membranes, chaperone removal or refolding of altered proteins, repair damaged DNA, or if necessary commit to programmed cell death. When cell injury is too extensive to permit reparative responses, acute cellular necrosis or apoptosis can result. Understanding injury at the subcellular organelle and molecular levels is essential for development of new therapeutic strategies and for optimal management of injured victims. In this volume, various modes of injury that can occur are described, as well as the basic molecular healing responses and pathways of metabolic survival or death. The approach taken here is to look at these processes at the cellular and subcellular levels, rather than at the tissue level, and this volume will be a valuable resource to anyone interested in wound healing, biological stress responses, molecular chaperones, radiobiology, biomechanics, and biomedical engineering, as well as trauma and critical care medicine. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.Table of ContentsForeword: Thomas K. Hunt. Introduction: Raphael C. Lee, Florin Despa, and Kimm J. Hamann. . Part I: Cell Structure and Integrity:. 1. Biological Water: Its Vital Role in Macromolecular Structure and Function: Florin Despa. 2. Thermal Stability of Proteins: John C. Bischof and Xiaoming He. 3. The Physics of the Interactions Governing Folding and Association of Proteins: Weihua Guo, Joan-Emma Shea, and R Stephen Berry. 4. Molecular Crowding Effects on Protein Stability: Florin Despa, Dennis P. Orgill, and Raphael C. Lee. Part II: Modes of Cell Injury:. 5. Mechanical Cell Injury: Kenneth A. Barbee. 6. Cell Injury by Electric Forces: Raphael C. Lee. 7. Electroconformational Denaturation of Membrane Proteins: Wei Chen. 8. Heat Injury to Cells in Perfused Systems: Dennis P. Orgill, Stacy A. Porter, and Helena O. Taylor. 9. Cryo-Injury and Biopreservation: Alex Fowler and Mehmet Toner. 10. Oxidative Reactive Species in Cell Injury: Mechanisms in Diabetes Mellitus and Therapeutic Approaches: Leonid E. Fridlyand and Louis H. Philipson. Part III: Cellular Responses to Injury:. 11. The Mechanisms of Cell Membrane Repair: A Tutorial Guide to Key Experiments: Richard A. Steinhardt. 12. The Role of Ca2+ in Muscle Cell Damage: Hanne Gissel. 13. Protein Denaturation and Aggregation: Cellular Responses to Denatured and Aggregated Proteins: Stephen C. Meredith. 14. Thermally Induced Injury and Heat-Shock Protein Expression in Cells and Tissues: Marissa Nichole Rylander, Yusheng Feng, Jon Bass, and Kenneth R. Diller. 15. Cellular Response to DNA Damage: Johnny Kao, Barry S. Rosenstein, Sheila Peters, Michael T. Milano, and Stephen J. Kron. 16. Autophagy: Ameeta Kelekar. 17. Magnetic Resonance Imaging of Changes in Muscle Tissues after Membrane Trauma: Hanne Gissel, Florin Despa, John Collins, Devkumar Mustafi, Katherine Rojahn, Greg Karczmar, and Raphael Lee. Part IV: Therapeutics for Cell Injury:. 18. Na+-K+ Pump Stimulation Improves Contractility in Damaged Muscle Fibers: Torben Clausen. 19. Multimodal Strategies for Resuscitating Injured Cells: Jayant Agarwal, Alexandra Walsh, and Raphael C. Lee. 20. Membrane Sealing by Polymers: Stacey A. Maskarinec, Guohui Wu, and Ka Yee C. Lee. 21. A Surfactant Copolymer Facilitates Functional Recovery of Heat-Denatured Lysozyme: Alexandra M. Walsh, Devkumar Mustafi, Marvin W. Makinen, and Raphael C. Lee. Index of Contributors

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Book SynopsisThis first edition volume demystifies the complex topic of flow cytometry by providing detailed explanations and nearly 120 figures to help novice flow cytometry users learn and understand the bedrock principles necessary to perform basic flow cytometry experiments correctly.The book divides the topic of flow cytometry into easy to understand sections and covers topics such as the physics behind flow cytometry, flow cytometry lingo, designing flow cytometry experiments and choosing appropriate fluorochromes, compensation, sample preparation and controls and ways to assess cellular function using a variety of flow cytometry assays. Written as a series of chapters whose concepts sequentially build off one another, using the list of materials contained within each section along with the readily reproducible laboratory protocols and tips on troubleshooting that are included, readers should be able to reproduce the data figures presented throughout the book on their way to mastering sound basic flow cytometry techniques. Easy to understand and comprehensive, Flow Cytometry Basics for the Non-Expert will be a valuable resource to novice flow cytometry users as well as experts in other biomedical research fields who need to familiarize themselves with a basic understanding of how to perform flow cytometry and interpret flow cytometry data. This book is written for both scientists and non-scientists in academia, government, biotechnology, and medicine. Table of Contents1. Flow Cytometry: Definition, History, and Uses in Biotechnology.- 2. Physics of a Flow Cytometer.- 3. The Language of Flow Cytometry and Experimental Setup.- 4. Fluorochrome Choices for Flow Cytometry.- 5. Compensation.- 6. Primary and Seconardy Antibodies and Their Use in Flow Cytometry.- 7. Experimental Considerations with Data Sets as Examples.- 8. Cell Enrichment.- 9. Surface and Intracellular Staining Protocols for Flow Cytometry.- 10. Troubleshooting.

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Book SynopsisThe book in question is primarily designed to serve as a companion for students of cytogenetics within the fields of Genetics and Plant Breeding. Through the use of illustrations and clear explanations, the book aims to make the fundamental concepts of the subject accessible to even beginners. The books organization strictly adheres to the course curriculum taught in universities, ensuring that the content is both relevant and comprehensive. The topics covered in the book have been arranged in a concise and easily understandable manner, deliberately avoiding the complexity often found in traditional textbooks. This book is intended to supplement, not replace, primary texts.

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Book SynopsisHave you ever wondered what our body is made up of and what it looks like under a microscope? How does our body work and how can we protect it against dangerous invaders?Our body is made up of four main types of tissues and 200 different types of cells organized into groups, working together, forming the organs and systems of our body. A pathologist, like me, is a doctor who studies tissues and cells under a microscope and has the essential knowledge to identi-fy and describe their diseases. This work is a long, lonely, scientific journey, where hundreds of his-tological images alternate daily in front of our eyes like scenes from a silent movie. This micro-scopic, lonely journey becomes magical when cells inadvertently form images of beauty similar to that found in paintings. Images of childhood memories and drawings, like a flower, a heart, an animal, a toy, shapes and colours changing with every moment, remind us of works of art created with sophistication and devotion by a great artist.Get ready for a journey into our wonderful, magical inner world; the organs and systems of our body. Page by page you will discover the amazing images of our tissues and cells revealed under the microscope. You will also learn how to protect yourselves against invisible enemies, viruses, and germs. Welcome to a unique scientific journey! You will be amazed at the beauty of knowledge!The creation of this book was the result of a collective effort between a group of people who worked with me and the publishing house that implemented it. Our common denominator was the magical combination of Science and Art. First of all, I would like to deeply thank, Niki Papatheochari, a diverse and significant personality, who, through her unique work, embodies a picture of perpetual creativity. It is a special honour for me that she prefaced the first edition of my book and contributed valuable advice and inspirational interventions. I thank her for warmly embracing this effort from beginning to end, and for the invaluable knowledge that she generously offered, both as a scientist and as a human being. I wholeheartedly thank the Emeritus Professor of Surgery at the University of Athens Vasileios Golematis, a prominent figure in the global medical and academic community, for prefacing the second edition of my book. Professor Vasileios Golematis, a distinguished scientist and an exceptional man, is a model university teacher and an inexhaustible source of inspiration for his students and colleagues. I would like to warmly thank the medical students Vagia Karapepera, for her wonderful sketches inspired by my lectures in Histology, and Michael Tsierkezos, for setting the book's text to music from which the accompanying video clip emerged. I would also like to thank Eleni Nalbandi for her valuable assistance in editing. Finally, I am really thankful to my family and all those who helped me with their know-how and moral support in completing this original project. Maria Lambropoulou

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