Regenerative medicine: stem cells Books
Elsevier Science Cancer Stem Cells
Book SynopsisTable of Contents1. Regulation of cancer stem cell properties by SIX1, a member of the PAX-SIX-EYA-DACH networkTami J. Kingsbury, MinJung Kim and Curt I. Civin2. Dormancy and cancer stem cells: An enigma for cancer therapeutic targetingSarmistha Talukdar, Praveen Bhoopathi, Luni Emdad, Swadesh Das, Devanand Sarkar and Paul B. Fisher3. Clonal hematopoiesis: Pre-cancer PLUSAlexander J. Silver and Siddhartha Jaiswal4. Assays for functionally defined normal and malignant mammary stem cells Syed M. Musheer Aalam, Philip A. Beer and Nagarajan Kannan5. Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapyLisha Xiang and Gregg L. Semenza6. Exploiting epigenetically mediated changes: Acute myeloid leukemia, leukemia stem cells and the bone marrow microenvironment Aksinija A. Kogan, Rena G. Lapidus, Maria R. Baer and Feyruz V. Rassool
£104.00
MIT Press Ltd The Future of Brain Repair A Realists Guide to
Book SynopsisA scientist assesses the potential of stem cell therapies for treating such brain disorders as stroke, Alzheimer's disease, and Parkinson's disease.Stem cell therapies are the subject of enormous hype, endowed by the media with almost magical qualities and imagined by the public to bring about miracle cures. Stem cells have the potential to generate new cells of different types, and have been shown to do so in certain cases. Could stem cell transplants repair the damaged brain? In this book, neurobiologist Jack Price assesses the potential of stem cell therapies to treat such brain disorders as stroke, Alzheimer's disease, Parkinson's disease, and spinal cord injuries.Certainly brain disorders are in need of effective treatments. These disorders don't just kill, they disable, and conventional drug therapies have not had much success in treating them. Price explains that repairing the human brain is difficult, largely because of its structural, functional, and developme
£22.95
John Wiley and Sons Ltd The Science of Stem Cells
Book SynopsisIntroduces all of the essential cell biology and developmental biology background for the study of stem cells This book gives you all the important information you need to become a stem cell scientist. It covers the characterization of cells, genetic techniques for modifying cells and organisms, tissue culture technology, transplantation immunology, properties of pluripotent and tissue specific stem cells and, in particular, the relevant aspects of mammalian developmental biology. It dispels many misconceptions about stem cellsespecially that they can be miracle cells that can cure all ills. The book puts emphasis on stem cell behavior in its biological context and on how to study it. Throughout, the approach is simple, direct, and logical, and evidence is given to support conclusions. Stem cell biology has huge potential for advancing therapies for many distressing and recalcitrant diseases, and its potential will be realized most quickly when as many people as possible have a good grTable of ContentsPreface xi About the Companion Website xiii 1 What is a Stem Cell? 1 Stem Cell Markers 3 Label‐ Retention 4 The Niche 5 Asymmetric Division and Differentiated Progeny 6 Clonogenicity and Transplantation 6 In Vivo Lineage Labeling 7 Conclusions 9 Further Reading 10 2 Characterizing Cells 13 Histological and Anatomical Methods 13 Histological Sections 13 Fixation 13 Sectioning 14 Staining 14 Electron Microscopy 15 Fluorescence Microscopy 16 Wholemounts 17 Immunostaining 17 In Situ Hybridization 18 Other Methods 19 RNAseq 19 Laser Capture Microdissection 19 Flow Cytometry 20 Dividing Cells 21 The Cell Cycle 21 Studying Cell Turnover 24 Reporters for the Cell Cycle 26 Identification of Very Slow Cell Turnover 26 Classification of Cell Types by Proliferative Behavior 28 Cell Death 28 Further Reading 30 3 Genetic Modification and the Labeling of Cell Lineages 31 Introducing Genes to Cells 31 Transfection and Electroporation 31 Gene Delivery Viruses 33 Controlling Gene Expression 35 Tet System 35 Cre System 35 Inhibiting Gene Activity 37 CRISPR‐Cas9 37 Transgenic Mice 38 Animal Procedures 38 Modification of Embryonic Stem Cells 40 Types of Transgenic Mice 41 Cell Lineage 42 Cell Lineage, Fate Maps, Clonal Analysis 43 Use of CreER for Lineage Analysis 44 Retroviral Barcoding 46 Clonal Analysis in Humans 47 Further Reading 47 4 Tissue Culture, Tissue Engineering and Grafting49 Simple Tissue Culture 51 Media 51 Contamination 53 Growth in Culture 54 Cryopreservation and Banking 55 GMP Cultivation 56 Complex Tissue Culture 56 Induced Differentiation 56 Three Dimensional Cell Culture 57 Artificial Organs and Organoids 59 Grafting 60 The Immune System 61 T Cells 61 The Major Histocompatibility Complex 62 T and B Cell Responses 63 Reactions to a Graft 64 Immunosuppressive Drugs 65 Animal Experiments Involving Grafting 66 Further Reading 67 5 Early Mouse and Human Development 69 Gametogenesis 70 Germ Cells 70 Mitosis and Meiosis 70 Primordial Germ Cells (PGCs) 72 Spermatogenesis 73 Oogenesis 73 Fertilization 76 Early Development 77 Preimplantation Phase 77 Implantation Period – Mouse 80 Implantation Period – Human 82 Ethical and Legal Issues Concerning the Early Human Conceptus 85 Sex Determination 86 X‐Inactivation 87 Imprinting 87 Cloning by Nuclear Transplantation (SCNT) 89 Further Reading 90 6 Pluripotent Stem Cells 93 Mouse Pluripotent Stem Cells 93 Mouse Embryonic Stem Cells 93 Differentiation of Mouse ES cells 95 Mouse iPS Cells 97 Human Pluripotent Stem Cells 101 SCNT‐Derived Embryonic Stem Cells 102 Ethical Issues Concerning Human ES Cells 102 Pluripotent Stem Cells from Postnatal Organisms 103 Applications of Pluripotent Stem Cells 104 Further Reading 105 7 Body Plan Formation 107 Embryological Concepts 107 Developmental Commitment 107 Embryonic Induction 109 Symmetry Breaking 110 Key Molecules Controlling Development 111 Genes Encoding Developmental Commitment 111 Inducing Factors 112 Wnt System 112 FGF System 113 Nodals and BMPs 114 Notch System 114 Hedgehog System 115 Growth Promoting Pathways 115 Retinoic Acid 115 Body Plan Formation 116 General Body Plan 116 Gastrulation 116 Embryo Folding 120 Further Reading 123 8 Organogenesis 125 Nervous System 125 The Brain 126 Regional Specification of the CNS 128 Rostrocaudal 128 Mediolateral 130 Dorsoventral 131 The Eye 131 The Neural Crest 132 Epidermis 134 Hair Follicles 135 Mammary Glands 136 Somitogenesis 137 The Somite Oscillator and Gradient 138 Subdivision of the Somites 139 Myogenesis 140 The Kidney 140 Blood and Blood Vessels 142 Blood 142 Blood Vessels 143 The Heart 145 The Gut 146 Regional Specification of the Endoderm 148 The Intestine 149 The Pancreas 150 The Liver 150 Further Reading 151 9 Cell Differentiation and Growth 155 Organs, Tissues and Cell Types 155 Epithelia 156 Connective Tissues 156 Cell Differentiation 158 Regulation of Gene Activity 158 Lateral Inhibition 161 Asymmetrical Cell Division 162 Neurogenesis and Gliogenesis 164 Neurons and Glia 164 Neurogenesis 166 Gliogenesis 168 Postnatal Cell Division 169 Adult Neurogenesis 169 Neurospheres 171 Skeletal and Cardiac Muscle 171 Skeletal Muscle 171 Development of Skeletal Muscle 172 Muscle Satellite Cells 173 Cardiac Muscle 175 Endodermal Tissues 176 Cell Differentiation in the Pancreas 176 Cell Differentiation in the Intestine 178 Cell Differentiation in the Liver 179 Hepatocytes and Cholangiocytes 180 Liver Growth and Regeneration 181 Transdifferentiation and Direct Reprogramming of Cell Type 183 Differentiation Protocols for Pluripotent Stem Cells 184 Further Reading 185 10 Stem Cells in the Body 189 The Intestinal Epithelium 189 Intestinal Stem Cells 191 In Vitro Culture 193 Clonality of Intestinal Crypts 193 The Epidermis 195 Hair Follicles 197 Cornea and Limbus 199 Mammary Glands 200 Mammary Stem Cells 203 The Hematopoietic System 204 Analysis by Transplantation and in Vitro Culture 204 Hematopoiesis in the Steady State 207 The Hematopoietic Niche 209 Spermatogenesis 211 Further Reading 213 11 Regeneration, Wound Healing and Cancer 217 Planarian Regeneration 217 Neoblasts 218 Amphibian Limb Regeneration 220 The Regeneration Blastema 220 Pattern Formation in Regeneration 222 Mesenchymal Stem Cells 223 Mammalian Wound Healing 225 Soft Tissue Wounds 225 Healing of Bone Fractures 225 Spinal Cord Injuries 227 Regeneration and Repair 228 Cancer 228 Genetic Heterogeneity of Cancer 230 Cancer Stem Cells 233 Further Reading 236 Index 239
£79.16
Nova Science Publishers Inc Stem Cells in Disease Pathogenesis
Book SynopsisThe normal functioning of the human female reproductive system is sacrosanct, as it allows for the essential nurturing of offspring. Conditions such as endometriosis and fibroid formation can have devastating consequences to the progeny, as well as the parents, both physically and mentally. This book has several chapters that deal with the role of stem cells in the safer outcome of pregnancies. Mesenchymal stem cells continue to make waves as various researchers dwell on their low immunogenicity to prevent graft rejection when used for therapeutic strategies. Dental pulp-derived stem cells are being sought after to address many therapies. However, researchers must exercise ethical caution to avoid resorting to pulling out the teeth of live, healthy animals, including those qualified for pets. The efficacy of cancer treatments with naturally occurring plant-derived substances and the characterization of cancer stem cells and lesions continue to engage researchers of this ever-perennial disease and its potentially lethal pathology. Stem cells to replenish the pancreatic islet cells from induced pluripotent stem cells are an actively pursued subject in regenerative medicine for diabetes patients. Stem cells in immune responses are also attracting researchers to investigate immune tolerance and autoimmunity.Table of ContentsPreface; Stem Cells of Female Reproductive System: Endometrium vs Fallopian Tube; Anti-angiogenic Potential of Itraconazole and Its Reversal by Endometrial Stem Cells Using Chick Embryo Model; Intrauterine Infusion of Human Autologous Peripheral Blood Mononuclear Cells Improves In Vitro Fertilization Success in Infertile Women; Development and Characterization of Hematopoietic Stem Cells from Human Embryonic Stem Cells; Mutation Analysis of MTHFR Gene in Indian Women with Unexplained Recurrent Miscarriages; Folic Acid Supplementation Improves Pregnancy Outcomes; Comparison of the Proliferation Potential of Bone Marrow and Adipose- Derived Mesenchymal Stem Cells Cultivating on Human Amniotic Membrane; Efficacy of the Mesenchymal Stem Cells Therapy Combined with Core Decompression in Avascular Necrosis of the Femoral Head: A Systematic Review and Meta-analysis of Clinical Trials; Proliferation Capacity and Osteogenic Potential of Human Gingival Stem Cells versus Human Dental Pulp Stem Cells; Comparison between the Effect of MTA and Biodentine on Proliferation and Odontogenic Differentiation of Dental Pulp Stem Cells (In Vitro Study); The Monomeric Resins TEGDMA and HEMA Regulate the Transcriptional Control of Matrix Metalloproteinases MMP-2 and MMP-9, in Human Pulp Fibroblasts and Mesenchymal Stem Cells; Effect of Dental Stem Cells on T Cell Proliferation; Amount of Bone Morphogenetic Protein-2, Epidermal Growth Factor, and Vascular Endothelial Growth Factor in Adipose Tissue, Umbilical Cord, and Bone Marrow Mesenchymal Stem Cell Derived Secretome: An In-Vitro Study; Identified Cancer Stem Cells (CSCs) in Ex- Vivo Cultured Acute Lymphoid Leukemia (B-ALL) Cells; Role of Simarouba glauca DC Plant in Cancer: A Short Review; Study of Histomorphological Spectrum of Thyroid Lesions in Thyroidectomy Specimens, Along with Cytological Correlation: Cross Sectional Study from 2015 to 2018; Generation of Pancreatic β Cells from Peripheral Blood Mononucleocytes Derived Induced Pluripotent Stem Cells; Stem Cells: An Exciting Avenue for Diabetes Mellitus; Regenerations Role in the Development of Desensitization and Immunological Tolerance; Features of the Immune Response to Ones Own Antigens and Foreign Antigens; Regenerative Approach to the Treatment of COVID-19 Patients; Medical Applications of Infrared Thermography: A Narrative Review; Index.
£163.19
Humanix Books The Stem Cell Cure: Remake Your Body and Mind
Book SynopsisThe 150+ year lifespan of our ancient ancestors can be achieved once again by harnessing the power of our own cells with The Stem Cell Cure! Renowned regenerative and restorative sports medicine doctor Gaurav Goswami, M.D. provides advanced minimally invasive, non-surgical treatments to help his patients get back to peak performance levels – no matter their age. Harnessing the transformative power of stem cells is central to his expertise. In fact, stem cell therapy is proven to be effective in the treatment of many common conditions from arthritis and back pain to Alzheimer’s, Parkinson’s, and cancer. This book is an accessible and informative introduction to the amazing powers of Stem Cell Therapy – the biggest revolution in medicine since the discovery of penicillin, and a wave of the future. Co-authored by bestselling author and popular keynote speaker Kerry Johnson MBA PhD, The Stem Cell Cure provides specific ways for readers to boost their health and vitality for a lifetime by recovering, regenerating, and repairing injuries and disease.Trade ReviewPatient Testimonials for Doctor Goswami & Praise for his book The Stem Cell Cure: Remake Your Body and Mind “Doctor Goswami was such a great find as I was at the point of giving up my cherished trail running and climbing pursuits. Well after two stem cell treatments I am back at it, and am looking forward to many more years of joy. I greatly appreciated the care he took explaining in detail the procedure, the care in execution, and the many caring follow up calls. He is the best! We are excited that many more will learn and gain more knowledge about stem cells through this wonderful book.” — Megan and Paul Stevenson “Fascinating read. As a successful recipient of stem cell treatment for my shoulder, it was very rewarding to learn about the science behind The Stem Cell Cure. I highly recommend this book to anyone who would love to stay active and avoid surgery.” — Eric Davidson, Owner of Orange County Breakers and World Team Tennis “I tore my entire knee playing football in college and was trending toward replacement. The stem cell procedure was a breeze. After six months, I could see regrown cartilage with improvements in motion. I knew there had to be a better route than cutting myself open again with another surgery. This book helps distill important concepts of stem cell therapy, I recommend it to every athlete and non-athlete.” — Michael Spanos II, Los Angeles ChargersTable of ContentsThe Stem Cell Cure: Remake Your Body and Mind Table of Contents Preface...............................xi Chapter 1 Welcome to the World of Stem Cells.......1 Chapter 2 Understanding Disease, Injury, and Aging...17 Chapter 3 How Stem Cells Work..................29 Chapter 4 Sources and Types of Stem Cells..........41 Chapter 5 Stem Cells and Joint Pain...............59 Chapter 6 Stem Cells and Back Pain...............73 Chapter 7 Stem Cells and Sports Injuries...........87 Chapter 8 Stem Cells and Your Sex Life...........103 Chapter 9 Stem Cells and Your Heart and Lungs....117 Chapter 10 Stem Cells and Autoimmune Conditions..127 Diabetes, Kidney Failure, and Lupus Chapter 11 Stem Cells in Autism, Stroke, MS, and Alzheimer’s Disease...............141 Chapter 12 Healing from Within..................153 Chapter 13 Stem Cells and the FDA...............169 Chapter 14 A Patient’s Journey with Stem Cells......181 Kerry Johnson’s Story in His Own Words Chapter 15 The Future Is Now....................193 Acknowledgments....................205 Index..............................207
£16.19
Royal Society of Chemistry Biomaterial Control of Therapeutic Stem Cells
Book SynopsisHuman pluripotent stem cells (hPSCs), which cover both human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), show promise for drug discovery and regenerative medicine applications. These stem cells cannot be cultured on conventional tissue culture dishes but on biomaterials that have specific interactions with the hPSCs. Differentiation is regulated by the biological and physical cues conferred by the biomaterial. This book provides a systematic treatment of these topics bridging the gap between fundamental biomaterials research of stem cells and their use in clinical trials. The author looks at hPSC culture on a range of biomaterial substrates. Differentiation and control of hESCs and iPSCs into cardiomyocytes, osteoblasts, neural lineages and hepatocytes are covered. The author then considers their translation into stem cell therapies and looks at clinical trials across spinal cord injury, macular degeneration, bone disease and myocardial infarction. Finally, a chapter on future directions closes the book. By using this book, the reader will gain a robust overview of current research and a clearer understanding of the status of clinical trials for stem cell therapies.Table of ContentsIntroduction; Adult Stem Cell Culture on Extracellular Matrices and Natural Biopolymers; Feeder-free and Xeno-free Culture of Human Pluripotent Stem Cells on Biomaterials; Differentiation Fates of Human ES and iPS Cells Guided by Physical Cues of Biomaterials; Biomaterial Control of Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells; Clinical Trials of Stem Cell Therapies Using Biomaterials; Conclusions and Future Perspective on Biomaterial Control of Therapeutic Stem Cells
£160.55
World Scientific Publishing Co Pte Ltd Stem Cells: From Hype To Hope
Book SynopsisDuring the last two decades, stem cells have progressed from merely a concept to a vibrant field of regenerative medicine which is aimed at addressing the root cause of the problem rather than conventional methods of intervention that mostly provide symptomatic relief.Stem cell therapy either alone or in combination with the other established treatment strategies is a hope for patients who suffer from the 'incurable' diseases such as Alzheimer, diabetes, myocardial infarction etc. Besides aspirations in the clinical perspective, stem cells provide excellent in vitro disease models for drug development.Given the significance of the field, the proposed book will be a compilation of the bench experience of experts from various research labs involved in the cutting edge area of stem cell research.
£85.50
World Scientific Publishing Co Pte Ltd Cells And Stem Cells: The Myth Of Life Sciences
Book SynopsisThis popular science book systematically introduces major scientific and technological achievements in the field of cells and stem cells, and the conveniences they bring to human life. It covers plant cloning, animal cloning, human cloning, biological missiles, biological drugs, immunocytotherapy, stem cell therapy, stem cell bank, 4D printing, 5D printing, CAR-T technology, and other frontier fields, which reflect the latest progresses and development trends of life sciences. The book is both interesting and rich in information, revealing the magic and mystery of life sciences.
£52.25
World Scientific Publishing Co Pte Ltd Cells And Stem Cells: The Myth Of Life Sciences
Book SynopsisThis popular science book systematically introduces major scientific and technological achievements in the field of cells and stem cells, and the conveniences they bring to human life. It covers plant cloning, animal cloning, human cloning, biological missiles, biological drugs, immunocytotherapy, stem cell therapy, stem cell bank, 4D printing, 5D printing, CAR-T technology, and other frontier fields, which reflect the latest progresses and development trends of life sciences. The book is both interesting and rich in information, revealing the magic and mystery of life sciences.
£23.75
World Scientific Publishing Co Pte Ltd Science, Politics, Stem Cells And Genes:
Book SynopsisIs there a way to fight back against 'incurable' disease? California thought so — and put its money where its mind was — three billion dollars' worth! And when that was gone, how about five and a half billion dollars more — to build and expand the California Institute for Regenerative Medicine?For some, science excites; it is the great adventure, to challenge the impossible: like a real-life battle with a giant squid, or the proposed disassembly of the Eiffel Tower, or ejecting from a jet in the sky, from a height greater than Mount Everest.For others, regenerative medicine is a mystery — could the urge to do murder have a genetic cause — which might be reduced?And for everyone, there is the fight to protect our loved ones' lives— 133 million of us, suffering from chronic disease — from America alone, a colossal cost of $3 trillion dollars last year.An epic battle, 'Science, Politics, Stem Cells and Genes: CALIFORNIA'S WAR ON CHRONIC DISEASE' takes the reader behind the scenes.An award-winning teacher, Reed shares science in stories — including the systematic assault on Alzheimer's disease, cancer, autism, epilepsy, liver failure, schizophrenia, obesity, stroke, sickle cell, arthritis, blindness, paralysis, kidney failure, ALS, aging, and much, much more.Readers can expect a greater understanding of the intricate adventure of stem cell research, as well as the political wrestling it took to make progress possible — that California's effort may benefit the world.From early research to clinical trials, America should take pride in the accomplishments of the California Institute for Regenerative Medicine.Read on.
£99.00
World Scientific Publishing Co Pte Ltd Science, Politics, Stem Cells And Genes:
Book SynopsisIs there a way to fight back against 'incurable' disease? California thought so — and put its money where its mind was — three billion dollars' worth! And when that was gone, how about five and a half billion dollars more — to build and expand the California Institute for Regenerative Medicine?For some, science excites; it is the great adventure, to challenge the impossible: like a real-life battle with a giant squid, or the proposed disassembly of the Eiffel Tower, or ejecting from a jet in the sky, from a height greater than Mount Everest.For others, regenerative medicine is a mystery — could the urge to do murder have a genetic cause — which might be reduced?And for everyone, there is the fight to protect our loved ones' lives— 133 million of us, suffering from chronic disease — from America alone, a colossal cost of $3 trillion dollars last year.An epic battle, 'Science, Politics, Stem Cells and Genes: CALIFORNIA'S WAR ON CHRONIC DISEASE' takes the reader behind the scenes.An award-winning teacher, Reed shares science in stories — including the systematic assault on Alzheimer's disease, cancer, autism, epilepsy, liver failure, schizophrenia, obesity, stroke, sickle cell, arthritis, blindness, paralysis, kidney failure, ALS, aging, and much, much more.Readers can expect a greater understanding of the intricate adventure of stem cell research, as well as the political wrestling it took to make progress possible — that California's effort may benefit the world.From early research to clinical trials, America should take pride in the accomplishments of the California Institute for Regenerative Medicine.Read on.
£52.25
