Chemotherapy / Pharmacotherapy Books

Book SynopsisOn the night of December 2, 1943, the Luftwaffe bombed a critical Allied port in Bari, Italy, sinking seventeen ships and killing over a thousand servicemen and hundreds of civilians. Caught in the surprise air raid was the John Harvey,an American Liberty ship carrying a top-secret cargo of 2,000 mustard bombs to be used in retaliation if the Germans resorted to gas warfare.After young sailors began suddenly dying with mysterious symptoms, Lieutenant Colonel Stewart Alexander, a doctor and chemical weapons expert, was dispatched to investigate. He quickly diagnosed mustard gas exposure, which Churchill denied. Undaunted, Alexander defied British officials and persevered with his investigation. His final report on the Bari casualties was immediately classified, but not before his breakthrough observations about the toxic effects of mustard on white blood cells caught the attention of Colonel Cornelius P. Rhoads - a pioneering physician and research scientist as brilliant as he was arrogant and self-destructive - who recognized that the poison was both a killer and a cure, and ushered in a new era of cancer research.Deeply researched and beautifully written, The Great Secret is the remarkable story of how horrific tragedy gave birth to medical triumph.Trade ReviewIn a history that reads like a novel, Conant connects the 1943 bombing by the Nazis of an American ship containing banned mustard gas to the development of chemotherapy as a cancer treatment. * Editors’ Choice, NEW YORK TIMES BOOK REVIEW *[A] compelling narrative. . . . fascinating. * Wall Street Journal *Engrossing. . . . Convey[s] a fast-paced medical detective story that demonstrates how careful scientific observation can yield unexpected benefits and serves as a reminder of the difficult choices made by governments to balance public health and secrecy in matters of security. * Science *Conant delights in the devilish details, the hidden, overlooked, and deeply personal stories that constitute our collective historical record. In her deft and experienced hands, readers will discover great delight as well. * Air Mail *With a keen understanding of medical science, cancer, and the history of World War II, as well as an amazing range of sources, Conant dramatically illuminates a dark moment in history that eventually led to the medical breakthrough of chemotherapy. * National Book Review (US) *[A] fast-paced history-cum-detective story * Bloomberg News *the gripping story of a chemical weapons catastrophe, its cover-up, and how one army doctor's discovery led to the development of chemotherapy * Daily Times *the book succeeds as a history of chemotherapy's origins * Nature *Jennet Conant unravels the remarkable story of a World War Two chemical weapons disaster which inspired one of the twentieth century's greatest breakthroughs in medicine with verve and precision. The Great Secret reads like a wartime adventure and political thriller combined. -- Wendy Moore, author of ENDELL STREETWith a scintillating detective-tale plot rendered with an accomplished novelist's flair, Jennet Conant peels back the layers of deception employed by Allied authorities-including Winston Churchill-to conceal the fact that many of those who died at the Bari disaster in December 1943 perished from unprecedented exposure to mustard gas and immersion in ship fuel oil. This fast-paced narrative alone would make The Great Secret a landmark work, but Conant surpasses this with the even more astonishing chronicle of how insights into the Bari deaths ultimately galvanized the creation of the whole field of cancer chemotherapy. This is a heartbreaking and inspiring tale of tragedy leading to triumph. -- Richard B. Frank, author of TOWER OF SKULLS: A History of the Asia-Pacific War, July 1937–May 1942A ripping good yarn, jam-packed with marvelous prose, wonderful historical characters, and superb research on a little known but critical chapter in the history of medicine and the Second World War. I could not put this book down until I reached the final page. -- Howard Markel, MD, PhD, George E. Wantz Distinguished Professor of the History of MedicineAuthor and journalist Jennet Conant has uncovered a humdinger of a tale, one that is equal parts war story, conspiracy thriller and medical mystery. More than anything, The Great Secret shows how the dogged efforts of a handful of scientists were able to turn a wartime tragedy and coverup into one of society's greatest gifts. This is a rare jewel of a story that readers will love and fellow historians will covet. -- James M. Scott, Pulitzer Prize finalist and author of TARGET TOKYO and RAMPAGERemarkable...the story of a genuinely extraordinary man [told] uncommonly well. * Washington Post on TUXEDO PARK *A brilliant account of the all but vanished reputation of an amateur physicist who became a friend and peer of the greatest scientists of his time. -- Kurt Vonnegut on TUXEDO PARKTable of ContentsPrologue: "Little Pearl Harbor" Chapter One: "A Regiment of Wizards" Chapter Two: "The Die Is Cast" Chapter Three: "Angels in Long Underwear" Chapter Four: "Journey into the Nightmare" Chapter Five: "A Special Affinity" Chapter Six: "Recommendation to Secrecy" Chapter Seven: "Magnum Opus" Chapter Eight: "Forgotten Front" Chapter Nine: "A Riddle Wrapped in a Mystery" Chapter Ten: "Frontal Attack" Chapter Eleven: Trials and Tribulations Chapter Twelve: "The Sword and the Ploughshare" Epilogue: Belated Justice

Read more less

Book SynopsisDurante cuatro décadas, DeVita, Hellman y Rosenberg. Cáncer: principios y práctica de Oncología se ha posicionado como el estándar de referencia en la oncología. Esta obra magistral, creada bajo la batuta de los doctores Vincent T. DeVita, Jr., Theodore S. Lawrence y Steven A. Rosenberg, junto con un equipo destacado de colaboradores, ofrece orientación experta y estrategias para el abordaje integral de cada tipo de cáncer por estadio o presentación clínica. Desde su primera edición, esta obra ha reflejado a cabalidad el estado de la oncología en el mundo. Ahora en su duodécima edición, la obra integra una profunda renovación y sintonía con el estado actual de disciplinas como la biología del cáncer y sus diferentes formas de intervención clínica. El contenido se organiza en tres secciones principales en las que se cubren etiología y prevención del cáncer, terapéutica del cáncer y práctica clínica de la oncología. Cada sección se ha diseñado meticulosamente para ofrecer a los lectores los avances más recientes en biología molecular, tratamientos dirigidos, inmunoterapia y otras áreas cruciales de la especialidad.DeVita, Hellman y Rosenberg. Cáncer: principios y práctica de Oncología se mantiene como la referencia definitiva e indispensable para los profesionales dedicados y comprometidos con esta trascendente y dinámica especialidad médica.Table of ContentsPARTE I Etiología y prevención del cáncer PARTE II Terapéutica del cáncer PARTE III Práctica de la oncología PARTE IV Cuestiones sociales

Read more less

Book SynopsisThe complete guide to what to expect when you're expecting the worst.Reconstruction is a pragmatic but positive handbook for anyone navigating a diagnosis of primary breast cancer. It contains clear, useful advice on what to do and what to expect at all stages of treatment, from questions to ask your doctors and practical ways to reduce your risk of recurrence, right down to what to pack in your hospital bag.Written by journalist and breast cancer patient, Rosamund Dean, this reassuring guide combines the most up-to-date therapeutic information from a variety of medical experts with evidence-based lifestyle advice, and will help every patient to live well during treatment and beyond.Trade Review‘A brilliant, comprehensive guide for anyone with a breast cancer diagnosis. Clearly and calmly written – I wish this had been available when I was diagnosed.’Victoria Derbyshire ‘An inspirational, important and friendly book that will be a supportive companion to many women and men with breast cancer, as well as those that love them.’Melissa Hemsley ‘This book will help patients, their families and their friends to navigate the often confusing and overwhelming world following a cancer diagnosis.’Dr Lisa Dvorjetz ‘Empowering’Stylist ‘Rosamund is dedicated to improving the lives and experiences of people with breast cancer and this book is a tremendous collection of helpful tips for those embarking on, going through or coming out the other side of treatment. I look forward to sharing it with my patients.’Kat Tunnicliffe, oncological physiotherapist ‘Having a breast cancer diagnosis can be a lonely and overwhelming experience, and there is an overload of information right from the start. Rosamund’s book is not only the manual I wish I’d had, but also warm, funny and kind. It's like having a big sister who has been through the same thing, right by your side. Informative and calming, Reconstruction should be prescribed at the moment of that frightening diagnosis. Thank you, from the bottom of my heart.’Sarah Cawood, broadcaster ‘I wish a book like this had been given to me when diagnosed. It would have been the companion I absolutely needed to navigate the craziness of a breast cancer diagnosis and will support so many as they face their own frightening diagnosis.’Carly Moosah, breast cancer campaigner

Read more less

Book SynopsisTable of ContentsPart I: Principles of Virology 1. History and Impact of Virology 2. Classification of Viruses and Phylogenetic Relationships 3. Virion Structure and Composition 4. Virus Replication 5. Innate Immunity 6. Adaptive Immune Responses to Infection 7. Pathogenesis of Virus Infections 8. Patterns of Infection 9. Mechanisms of Viral Oncogenesis 10. Laboratory Diagnosis of Virus Diseases 11. Vaccines and Vaccination 12. Antiviral Chemotherapy 13. Epidemiology of Viral Infections 14. Control, Prevention, and Eradication 15. Emerging Virus Diseases Part II: Specific Virus Diseases of Humans 16. Poxviruses 17. Herpesviruses 18. Adenoviruses 19. Papillomaviruses 20. Polyomaviruses 21. Parvoviruses 22. Hepatitis B and Hepatitis Delta Viruses 23. Retroviruses 24. Reoviruses 25. Orthomyxoviruses 26. Paramyxoviruses 27. Rhabdoviruses 28. Filoviruses 29. Bunyaviruses 30. Arenaviruses 31. Coronaviruses 32. Picornaviruses 33. Caliciviruses 34. Astroviruses 35. Togaviruses 36. Flaviviruses 37. Hepeviruses 38. Prions 39. Viral Syndromes

Read more less

Book SynopsisThe gripping story of a chemical weapons catastrophe, the cover-up, and how one American Army doctor’s discovery led to the development of the first drug to combat cancer, known today as chemotherapy.Trade Review"In a history that reads like a novel, Conant connects the 1943 bombing by the Nazis of an American ship containing banned mustard gas to the development of chemotherapy as a cancer treatment." -- An Editors’ Choice of the New York Times Book Review"[A] compelling narrative.… fascinating." -- Laura Landro - Wall Street Journal"Engrossing.… Convey[s] a fast-paced medical detective story that demonstrates how careful scientific observation can yield unexpected benefits and serves as a reminder of the difficult choices made by governments to balance public health and secrecy in matters of security." -- Peter Reczek - Science"With a keen understanding of medical science, cancer, and the history of World War II, as well as an amazing range of sources, Conant dramatically illuminates a dark moment in history that eventually led to the medical breakthrough of chemotherapy." -- National Book Review"Few writers are better at finding new paths through the well-worn territory of World War II than historian Jennet Conant.... Conant delights in the devilish details, the hidden, overlooked, and deeply personal stories that constitute our collective historical record. In her deft and experienced hands, readers will discover great delight as well." -- Jessica Lahey - Air Mail"The Great Secret is a ripping good yarn, jam-packed with marvelous prose, wonderful historical characters, and superb research on a little-known but critical chapter in the history of medicine and the Second World War. I could not put this book down until I reached the final page." -- Howard Markel, MD, PhD, director of the Center for the History of Medicine, University of Michigan"With a scintillating detective-tale plot rendered with an accomplished novelist’s flair, Jennet Conant peels back the layers of deception employed by Allied authorities—including Winston Churchill—to conceal the fact that many of those who died at the Bari disaster in December 1943 perished from unprecedented exposure to mustard gas and immersion in ship fuel oil. This fast-paced narrative alone would make The Great Secret a landmark work, but Conant surpasses this with the even more astonishing chronicle of how insights into the Bari deaths ultimately galvanized the creation of the whole field of cancer chemotherapy. This is a heartbreaking and inspiring tale of tragedy leading to triumph." -- Richard B. Frank, author of Tower of Skulls: A History of the Asia-Pacific War, July 1937–May 1942"In her masterly The Great Secret, Jennet Conant has given us at once a crucial World War II story and a medical mystery as unsettling as it is gripping. As Conant’s hero (that’s not too strong a word), a US Army medical officer named Stewart Alexander, starts to unlock the secret that has caused scores of unnecessary deaths, he comes to understand the immense consequences of these now all-but-forgotten events, and sets in motion studies that&mdsah;as Ms. Conant explains with wonderfully lucid and vigorous authority—have shaped the medical landscape we inhabit today." -- Richard Snow, author of A Measureless Peril: America in the Fight for the Atlantic, the Longest Battle of World War II"Jennet Conant has uncovered a humdinger of a tale, one that is equal parts war story, conspiracy thriller and medical mystery. More than anything, The Great Secret shows how the dogged efforts of a handful of scientists were able to turn a wartime tragedy and coverup into one of society’s greatest gifts. This is a rare jewel of a story that readers will love and fellow historians will covet." -- James M. Scott, Pulitzer Prize finalist and author of Target Tokyo and Rampage"Jennet Conant unravels the remarkable story of a World War II chemical weapons disaster which inspired one of the twentieth century’s greatest breakthroughs in medicine with verve and precision. The Great Secret reads like a wartime adventure and political thriller combined." -- Wendy Moore, author of No Man’s Land: The Trailblazing Women Who Ran Britain’s Most Extraordinary Military Hospital During World War I

Read more less

Book SynopsisThis book provides an overview of different protein kinases structure, function, regulation, and their role in cancer. Itcombines kinase biology with chemistry and pharmacologyapplications for discovery and development of cancer drugs.Trade Review"The comprehensive coverage makes the book highly recommendable for beginners and expert researchers in oncology and should be present on their shelves." (ChemMedChem, November 2010)Table of ContentsPreface. Acknowledgments. 1 KINASES AND CANCER. 1.1 A Brief History of Protein Phosphorylation. 1.2 Kinases and Cancer. 1.3 A Tour of the Human Protein Kinase Superfamily. 1.3.1 Tyrosine Kinase Group. 1.3.2 TKL (Tyrosine Kinase-Like) Group. 1.3.3 STE Group. 1.3.4 CSNK1 Group. 1.3.5 AGC group. 1.3.6 CAMK Group. 1.3.7 CMGC Group. 1.3.8 RGC Group. 1.3.9 Others. 1.3.10 Atypical Protein Kinases. 1.3.11 Non-Protein Kinases. 1.4 Strategic Considerations for Selecting Kinases as Drug Targets. 1.5 Comparison of Kinase Inhibitor Therapeutic Strategies. 1.5.1 Small Molecule Versus Antibody-Directed Therapies. 1.5.2 Alternative Strategies for Kinase Inhibition. References. 2 PROTEIN KINASE STRUCTURE, FUNCTION AND REGULATION. 2.1 Ligand Binding to Receptor Tyrosine Kinases. 2.1.1 EGF:EGF Receptor Interactions. 2.1.2 Insulin:Insulin Receptor and IGF1:IGF1R. 2.1.3 FGF:FGF Receptor (Heparin/Heparan Sulphate) Interactions. 2.1.4 VEGF:VEGF Receptor Interactions. 2.1.5 Angiopoietin2:TIE2 Receptor Interactions. 2.1.6 Ephrin:EPH Receptor Interactions. 2.1.7 The Role of Transmembrane Domains. 2.2 Protein Kinase Domain Structure and Function. 2.3 Catalytic Activity of Protein Kinases. 2.3.1 Steady State Kinetics. 2.3.2 Chemistry of Protein Kinase Catalysis. 2.4 Protein Kinase Regulation. 2.4.1 Regulation Via Activation Segment Phosphorylation. 2.4.2 Regulation by N-terminal Sequences and Domains. 2.4.3 C-Terminal Regulatory Regions. 2.4.4 Regulation by Other Domains and Partner Proteins. References. 3 RECPETOR TYROSINE KINASES. 3.1 EGF/ERBB Receptors. 3.1.1 ERBB Receptors and Cancer. 3.2 Insulin/IGF Receptors. 3.2.1 Insulin/IGF Receptors and Cancer. 3.3 Anaplastic Lymphoma Kinase. 3.3.1 ALK and Cancer. 3.4 VEGF Receptors (VEGFR1, VEGFR2, VEGFR3). 3.5 PDGF Receptors. 3.5.1 PDGFRs and Cancer. 3.6 FGF Receptors. 3.6.1 FGFRs and Cancer. 3.7 KIT. 3.7.1 KIT and Cancer. 3.8 FLT3. 3.8.1 FLT3 and Cancer. 3.9 RET. 3.9.1 RET and Thyroid Carcinoma. 3.10 MET and RON. 3.10.1 MET. 3.10.2 RON. References. 4 NONRECEPTOR TYROSINE KINASES. 4.1 ABL. 4.2 ARG. 4.3 SRC and SRC Family Kinases. 4.3.1 SRC. 4.3.2 Cellular Roles of SRC. 4.3.3 SRC and Cancer. 4.4 FAK. 4.4.1 FAK and Cancer. 4.5 JAK2. 4.5.1 Activation and Known Mutations and Fusions of the JAK Family of Tyrosine Kinases. 4.5.2 Further Roles of JAK2 in Tumor Growth. References. 5 INTRACELLULAR SIGNAL TRANSDUCTION CASCADES. 5.1 The PI3K/PTEN Pathway. 5.1.1 PI3K. 5.1.2 PDK1. 5.1.3 AKT. 5.1.4 Other AGC Kinases. 5.1.5 PI3K Pathway Activation in Cancer. 5.2 mTOR Signaling. 5.2.1 mTOR. 5.2.2 p70S6 Kinase. 5.2.3 mTOR Pathway Activation in Cancer. 5.3 MAPK Signaling Pathways. 5.3.1 ERK/MAPK Signaling. 5.3.2 RAF Family Kinases. 5.3.3 MEK and ERK Kinases. 5.3.4 ERK/MAPK Pathway Activation in Cancer. 5.4 PIM Kinases. 5.5 Protein Kinase C. 5.5.1 PKC Activation. 5.5.2 Classical PKCs. 5.5.3 Novel PKCs. 5.5.4 Atypical PKCs. References. 6 CELL CYCLE CONTROL. 6.1 Cyclin-Dependent Kinases (CDKs) and Cell Cycle Progression. 6.1.1 Introduction. 6.1.2 CDK4 and CDK6. 6.1.3 CDK2. 6.1.4 CDK3. 6.1.5 CDK1. 6.1.6 CDK10. 6.1.7 CCRK/CDCH/p42. 6.2 CDKs and mRNA Production. 6.2.1 Introduction. 6.2.2 CDK7. 6.2.3 CDK8. 6.2.4 CDK9. 6.2.5 CDK11. 6.2.6 CDK12 (CDC2-Related Kinase CRKRS). 6.2.7 CDK13 (CDC2L5). 6.3 Other CDK-Related Kinases. 6.3.1 CDK5. 6.3.2 GAK. 6.4 Mitotic Kinases. 6.4.1 PLKs. 6.4.2 Aurora Kinases. 6.5 Cell Cycle Checkpoint Kinases. 6.5.1 ATM, ATR and DNAPK. 6.5.2 CHK1, CHK2 and MAPKAPK2. References. 7 STRUCTURAL BIOCHEMSITRY OF KINASE INHIBITORS. 7.1 Strategies for Inhibitor Design. 7.1.1 Targeting the Active Versus Inactive Form. 7.1.2 ATP-Competitive Versus Noncompetitive Inhibitors. 7.1.3 Specific Versus Multitargeted Inhibitors. 7.2 Architecture of the ATP Binding Site: DFG-in. 7.3 Case Study: Inhibitors of CHK1. 7.4 Case Study: Inhibitors of CDK2. 7.5 Case Study: Inhibitors of SRC Family Kinases. 7.6 Case Study: EGF Receptor Inhibitors. 7.7 Targeting the Inactive Conformation. 7.7.1 Binding Mode of Imatinib. 7.7.2 Binding of BAY-43-9006 (Sorafenib) to the Inactive BRAF Kinase. 7.8 Noncompetitive Inhibition. 7.9 Kinase Inhibitor Specificity. References. 8 TYROSINE KINASE INHIBITORS. 8.1 BCR-ABL Inhibitors. 8.2 SRC Inhibitors. 8.3 JAK2 Inhibitors. 8.4 EGFR/ERBB Inhibitors. 8.4.1 Determinants of Response and Resistance to ERBB Inhibitors. 8.5 IGF1R Inhibitors. 8.6 FLT3 Inhibitors. 8.7 KIT Inhibitors. 8.8 MET/RON Inhibitors. 8.9 RET Inhibitors. 8.10 Other Inhibitors. 8.10.1 FAK. 8.10.2 TGFß Receptor. References. 9 ANGIOKINASE INHIBITORS. 9.1 Introduction. 9.2 Angiokinase Inhibitors. References. 10 INTRACELLULAR SIGNALING KINASE INHIBITORS. 10.1 mTOR Inhibitors. 10.1.1 Clinical Pharmacodynamics and Tolerability of mTOR Inhibitors. 10.2 PI3K Inhibitors. 10.3 RAF Kinase Inhibitors. 10.4 MEK Inhibitors. 10.5 CDK Inhibitors. 10.6 Cell Cycle Checkpoint Kinase Inhibitors. 10.7 Mitotic Kinase Inhibitors. 10.7.1 PLK Inhibitors. 10.7.2 Aurora Kinase Inhibitors. 10.8 Protein Kinase C Inhibitors. References. 11 CURRENT CHALLENGES AND FUTURE DIRECTIONS. 11.1 Kinase Inhibitor Drug Resistance. 11.1.1 Efflux Pumps and Drug Transporters. 11.1.2 Other DMPK factors. 11.1.3 Target Mutation. 11.1.4 Target Overexpression and Activation. 11.1.5 Downstream Pathway Activation. 11.1.6 Redundant Receptors/Pathways. 11.2 Combination Therapy With Kinase Inhibitors. 11.2.1 Angiogenesis Inhibitors and Chemotherapy. 11.2.2 Survival Pathway Inhibitors and Chemotherapy/Targeted Therapy. 11.2.3 DNA Damage Checkpoint Inhibitors and Chemotherapy. 11.2.4 RTK Switching: Targeting Receptor Redundancy. 11.3 Systems Biology and Translational Medicine. 11.3.1 Classification of Tumors and Prediction of Response: Expression Profiling. 11.3.2 Phosphoprotein Analysis, Kinomics and Systems-Based Approaches. 11.3.3 Translational Medicine. 11.4 Conclusions. References. List of Abbreviations. Index.

Read more less

Book SynopsisThe development of drug-resistant cancers is considered to be the most significant obstacle to the cure of cancer today. Nearly half of all patients with cancer suffer from tumours that are intrinsically resistant to chemotherapy, and most of the remaining half develop drug resistance during the course of their treatment. This book reviews the mechanisms and clinical implications of drug resistance in cancer with unrivalled authority. Chapters cover topics of current clinical concern, including multiple drug resistance and its reversal, topoisomerase drugs, apoptosis, dose intensity and escalation, gene therapy and haematopoietic support. The authors are among the leading clinicians and investigators in the field. These authoritative volumes in this series are intended for a wide audience of clinicians and researchers with an interest in the applications of biomedical science to the understanding and management of cancer.Trade Review'… recommended for clinical oncologists, who will find extensive information on this topic which is seldom to be found in oncology textbooks.' Annals of Oncology'The strength of the book is related to the weaknesses described above. Multiple knowledgeable authors review topics related to drug resistance. Some of the authors primarily review their own work, while others try and update the reader on significant contributions from others. The book accomplishes what it is supposed to; it provides a way for the reader to learn and somewhat update his/her knowledge of drug resistance.' Howard Bailey, Madison, WisconsinTable of ContentsList of contributors; Series editor's preface; Abbreviations; 1. Resistance mechanisms to antimetabolites Erdem Göker, Richard Gorlick and Joseph R. Bertino; 2. Resistance to antitumor alkylating agents and cisplatin Beverly A. Teicher and Emil Frei III; 3. The MDR genes Lyn Mickley and Antonio Tito Fojo; 4. Topoisomerase genes and resistance to topoisomerase inhibitors Giuseppe Giaccone; 5. Genes that modulate apoptosis: major determinants of drug resistance John A. Hickman; 6. Clinical implications of drug resistance Henk M. W. Verheul and Herbert M. Pinedo; 7. The reversal of multidrug resistance William S. Dalton; 8. Effect of dose and schedule on chemotherapeutic drug resistance David Fennelly, George Raptis, John P. A. Crown and Larry Norton; 9. Circumvention of drug resistance by high-dose chemotherapy in solid tumors Elisabeth G. E. de Vries, Wil Dolsma, Geke A. P. Hospers and Nanno H. Mulder; 10. Enhancing drug effectiveness by gene transfer Karol Sikora; Index.

Read more less

Book Synopsis

Read more less

Book SynopsisExplores what it means to be structurally vulnerable; how structural vulnerabilities intersect with cancer risk, diagnosis, care seeking, caregiving, clinical-trial participation, and survivorship; and how differing local, national, and global political contexts and histories inform vulnerability.

Read more less

Book SynopsisThe gripping story of a chemical weapons catastrophe, the cover-up, and how one American Army doctor’s discovery led to the development of the first drug to combat cancer, known today as chemotherapy.Trade Review"In a history that reads like a novel, Conant connects the 1943 bombing by the Nazis of an American ship containing banned mustard gas to the development of chemotherapy as a cancer treatment." -- An Editors’ Choice of the New York Times Book Review"[A] compelling narrative.… fascinating." -- Laura Landro - Wall Street Journal"Engrossing.… Convey[s] a fast-paced medical detective story that demonstrates how careful scientific observation can yield unexpected benefits and serves as a reminder of the difficult choices made by governments to balance public health and secrecy in matters of security." -- Peter Reczek - Science"With a keen understanding of medical science, cancer, and the history of World War II, as well as an amazing range of sources, Conant dramatically illuminates a dark moment in history that eventually led to the medical breakthrough of chemotherapy." -- National Book Review"Few writers are better at finding new paths through the well-worn territory of World War II than historian Jennet Conant.... Conant delights in the devilish details, the hidden, overlooked, and deeply personal stories that constitute our collective historical record. In her deft and experienced hands, readers will discover great delight as well." -- Jessica Lahey - Air Mail"The Great Secret is a ripping good yarn, jam-packed with marvelous prose, wonderful historical characters, and superb research on a little-known but critical chapter in the history of medicine and the Second World War. I could not put this book down until I reached the final page." -- Howard Markel, MD, PhD, director of the Center for the History of Medicine, University of Michigan"With a scintillating detective-tale plot rendered with an accomplished novelist’s flair, Jennet Conant peels back the layers of deception employed by Allied authorities—including Winston Churchill—to conceal the fact that many of those who died at the Bari disaster in December 1943 perished from unprecedented exposure to mustard gas and immersion in ship fuel oil. This fast-paced narrative alone would make The Great Secret a landmark work, but Conant surpasses this with the even more astonishing chronicle of how insights into the Bari deaths ultimately galvanized the creation of the whole field of cancer chemotherapy. This is a heartbreaking and inspiring tale of tragedy leading to triumph." -- Richard B. Frank, author of Tower of Skulls: A History of the Asia-Pacific War, July 1937–May 1942"In her masterly The Great Secret, Jennet Conant has given us at once a crucial World War II story and a medical mystery as unsettling as it is gripping. As Conant’s hero (that’s not too strong a word), a US Army medical officer named Stewart Alexander, starts to unlock the secret that has caused scores of unnecessary deaths, he comes to understand the immense consequences of these now all-but-forgotten events, and sets in motion studies that&mdsah;as Ms. Conant explains with wonderfully lucid and vigorous authority—have shaped the medical landscape we inhabit today." -- Richard Snow, author of A Measureless Peril: America in the Fight for the Atlantic, the Longest Battle of World War II"Jennet Conant has uncovered a humdinger of a tale, one that is equal parts war story, conspiracy thriller and medical mystery. More than anything, The Great Secret shows how the dogged efforts of a handful of scientists were able to turn a wartime tragedy and coverup into one of society’s greatest gifts. This is a rare jewel of a story that readers will love and fellow historians will covet." -- James M. Scott, Pulitzer Prize finalist and author of Target Tokyo and Rampage"Jennet Conant unravels the remarkable story of a World War II chemical weapons disaster which inspired one of the twentieth century’s greatest breakthroughs in medicine with verve and precision. The Great Secret reads like a wartime adventure and political thriller combined." -- Wendy Moore, author of No Man’s Land: The Trailblazing Women Who Ran Britain’s Most Extraordinary Military Hospital During World War I

Read more less

Book SynopsisMechanism Of Cisplatin Resistance & Its Circumvention

Read more less

Book SynopsisPrinciples of Clinical Cancer Research provides comprehensive coverage of the fundamentals of clinical cancer research, including the full spectrum of methodologies used in the field. For those involved in research or considering research careers, this book offers a mix of practical advice and analytical tools for effective training in theoretical principles as well as specific, usable teaching examples. The clinical oncologist or trainee will find a high-yield, practical guide to the interpretation of the oncology literature and the application of data to real-world settings. Valuable for both researchers and clinicians who wish to sharpen their skills, this book contains all of the cornerstones and explanations needed to produce and recognize quality clinical science in oncology.Written from the physician-scientist's perspective, the book lays a strong foundation in preclinical sciences that is highly relevant to careers in translational oncology research along with coverage of population and outcomes research and clinical trials. It brings together fundamental principles in oncology with the statistical concepts one needs to know to design and interpret studies successfully. With each chapter including perspectives of both clinicians and scientists or biostatisticians, Principles of Clinical Cancer Research provides balanced, instructive, and high-quality topic overviews and applications that are accessible and thorough for anyone in the field.KEY FEATURES: Gives real-world examples and rationales behind which research methods to use when and why Includes numerous tables featuring key statistical methods and programming commands used in everyday clinical research Contains illustrative practical examples and figures in each chapter to help the reader master concepts Provides tips and pointers for structuring a career, avoiding pitfalls, and achieving success in the field of clinical cancer research Access to fully downloadable eBook

Read more less

Book SynopsisMetal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging concepts and enabling methods, as well as presenting key pre-clinical and clinical aspects. Recent progress on the unique features of next-generation targeted metal-based anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. With contributions from global leaders in the field, this book will serve as a useful reference to established researchers as well as a practical guide to those new to metallodrugs, and postgraduate students of medicinal chemistry and metallobiology.Table of ContentsEnhancing the Therapeutic Potential of Platinum-Based Anti-Cancer Agents by Incorporating Clinically Approved Drugs as Ligands; Ruthenium, Osmium and Iridium in the Fight Against Cancer; Iron Compounds as Anticancer Agents; Recent Advances in Anticancer Copper Compounds; Anticancer Gold Compounds; Heterometallic Complexes as Anticancer Agents; Vanadium Compounds as Enzyme Inhibitors with a Focus on Anticancer Effects; Arsenic-based Anticancer Agents; Supramolecular Metal-based Structures for Applications in Cancer Therapy; Enabling Methods to Elucidate the Effects of Metal-based Anticancer Agents; Metal-Based Radiotherapeutics; Challenges and Chances in the Pre-clinical to Clinical Translation of Anticancer Metallodrugs

Read more less

Book SynopsisPROLOG is a voluntary, strictly confidential, personal continuing education resource that is designed to be stimulating and enjoyable. By participating in PROLOG, obstetrician–gynecologists will be able to do the following:• Review and update clinical knowledge• Recognize areas of knowledge and practice in which they excel, be stimulated to explore other areas of the specialty, and identify areas requiring further study• Plan continuing education activities in light of identified strengths and deficiencies• Compare and relate present knowledge and skills with those of other participants• Obtain continuing medical education credit, if desired• Have complete personal control of the setting and of the pace of the experience.The obstetrician–gynecologist who completes Gynecologic Oncology and Critical Care, Eighth Edition, will be able to• identify epidemiologic factors that contribute to the risks of various malignancies and determine appropriate screening tests.• analyze the pathophysiology and evaluate the histopathology of various malignancies.• associate symptoms with early onset of specific malignancies, determine appropriate diagnostic tests, and select diagnosis.•

Read more less

Book SynopsisBodies Unbound is a comparative study showing how ideologies of gendered bodies shape medical care and the ways in which patients respond to these ideologies through decisions about their bodies using three cases: transgender men seeking preventative gynecological care, cisgender men diagnosed with breast cancer, and cisgender women with breast cancer who elect to undergo prophylactic mastectomies. Bodies Unbound is a story about how the relationship between bodies and gender becomes socially intelligible as well as how medical professionals use their position of relative authority over bodies to dictate which combinations of bodies and genders are legitimate or not. Drawing on the experiences of individuals whose bodies and gender identities don't match medical and social expectations for gynecological and breast cancer care, Sledge unravels the taken-for-granted alignment of bodies and gender that provide the foundation of medical care in the United States. Trade Review"Sledge’s fieldwork has led to a rich and vibrant analysis of how gender is enacted, resisted, performed, and policed in medical settings. Her accessible writing style and complex sociological analysis make this a powerful and unique contribution to the field."— Lisa Jean Moore, author of Buzz: Urban Beekeeping and the Power of the Bee "Bodies Unbound has many strengths and is written for scholars, students, and health practitioners who are interested in learning about how medicine normalizes and legitimizes gender and body and how patients and providers alike can resist and change the gendered health care system. Bodies Unbound makes important contributions to the scholarships of medical sociology, gender, and embodiment through addressing critical questions with careful analysis and compelling evidence."— Gender & Society "In a system that renders some relationships between bodies and gender identities legitimate and others illegitimate, Sledge employs an innovative research design that compares the experiences of patients with the ‘wrong body’ for gynecological and breast cancers. Each of these groups of patients disrupts normative expectations about gendered bodies. Conceptually integrating well-known but limiting 'doing gender' perspectives with more recent work on bio-citizenship, Sledge vividly illustrates how gendered biolegitimacy offers a powerful new theoretical framework for the study of gender and health."— Asia Friedman, associate professor of sociology, University of DelawareTable of ContentsContents List of Tables List of Images Acknowledgements Introduction 1. Entering Enemy Territory 2. Choosing Mastectomy 3. Returning to Normal 4. Ideologies of Gender in Surgical Cancer Care Conclusion Methodological Appendix Notes Bibliography Index

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book SynopsisThis monograph is a study of optimal control applied to cancer chemotherapy, the treatment of cancer using drugs that kill cancer cells. The aim is to determine whether current methods for the administration of chemotherapy are optimal, and if alternative regimens should be considered.The research utilizes the mathematical theory of optimal control, an active research area for many mathematicians, scientists, and engineers. It is of multidisciplinary nature, having been applied to areas ranging from engineering to biomedicine. The aim in optimal control is to achieve a given objective at minimum cost. A set of differential equations is used to describe the evolution in time of the process being modelled, and constraints limit the policies that can be used to attain the objective.In this monograph, mathematical models are used to construct optimal drug schedules. These are treatment guidelines specifying which drug to deliver, when, and at what dose. Many current drug schedules have been derived empirically, based upon “rules of thumb”.The monograph has been structured so that most of the high-level mathematics is introduced in a special appendix. In this way, a scientist can skip the more subtle aspects of the theory and still understand the biomedical applications that follow. However, the text is self-contained so that a deeper understanding of the mathematics of optimal control can be gained from the mathematical appendix.The mathematical models in this book and the associated computer simulations show that low intensity chemotherapy is a better choice of treatment than high intensity chemotherapy, under certain conditions.Table of ContentsBasic concepts; optimal control - theory and applications; multiple characteristic time (MCT) constraints; minimize the final tumour size; parameter uncertainty; forced decrease of tumour size; drug resistance I; drug resistance II; summary and conclusions; list of notation and symbols; appendix: elements of mathematical analysis.

Read more less