Engineering applications of bio-materials Books

Book SynopsisThis open access volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention. Beginning with a section on the design of antisense technology and their delivery, the book continues by covering model systems developed to evaluate efficacy, both in vivo and in vitro, as well as methods to evaluate preclinically the toxicity associated with these new potential drugs, and intellectual property considerations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Antisense RNA Design, Delivery, and Analysis provides basic knowledge and a large collection of methods to facilitate the work Table of ContentsPart I: Overview 1. Introduction and History of the Chemistry of Nucleic Acids Therapeutics Michael J. Gait and Sudhir Agrawal 2. Antisense RNA Therapeutics: A Brief Overview Virginia Arechavala-Gomeza and Alejandro Garanto Part II: Design and Formulation of Antisense Technology 3. Design of Bifunctional Antisense Oligonucleotides for Exon Inclusion Haiyan Zhou 4. Design and Delivery of SINEUP: A New Modular Tool to Increase Protein Translation Michele Arnoldi, Giulia Zarantonello, Stefano Espinoza, Stefano Gustincich, Francesca Di Leva, and Marta Biagioli 5. How to Design U1 snRNA Molecules for Splicing Rescue Liliana Matos, Juliana I. Santos, Mª Francisca Coutinho, and Sandra Alves 6. Conjugation of Nucleic Acids and Drugs to Gold Nanoparticles Paula Milán-Rois, Ciro Rodriguez-Diaz, Milagros Castellanos, and Álvaro Somoza 7. Determination of Optimum Ratio of Cationic Polymers and Small Interfering RNA with Agarose Gel Retardation Assay Omer Aydin, Dilek Kanarya, Ummugulsum Yilmaz, and Cansu Umran Tunc 8. Generation of Protein-Phosphorodiamidate Morpholino Oligomer Conjugates for Efficient Cellular Delivery via Anthrax Protective Antigen Valentina Palacio-Castañeda, Roland Brock, and Wouter P.R. Verdurmen Part III: In Vitro Model Systems 9. Development and Use of Cellular Systems to Assess and Correct Splicing Defects Nuria Suárez-Herrera, Tomasz Z. Tomkiewicz, Alejandro Garanto, and Rob W.J. Collin 10. Modeling Splicing Variants Amenable to Antisense Therapy by Use of CRISPR-Cas9-Based Gene Editing in HepG2 Cells Arístides López-Márquez, Ainhoa Martínez-Pizarro, Belén Pérez, Eva Richard, and Lourdes R. Desviat 11. In Vitro Models for the Evaluation of Antisense Oligonucleotides in Skin Jeroen Bremer and Peter C. van den Akker 12. In Vitro Delivery of PMOs in Myoblasts by Electroporation Remko Goossens and Annemieke Aartsma-Rus 13. Rapid Determination of MBNL1 Protein Levels by Quantitative Dot Blot for Evaluation of Antisense Oligonucleotides in Myotonic Dystrophy Myoblasts Nerea Moreno-Cervera, Irene Gonzalez-Martinez, Rubén Artero, and Estefanía Cerro-Herreros 14. Evaluation of Exon Skipping and Dystrophin Restoration in In Vitro Models of Duchenne Muscular Dystrophy Andrea López-Martínez, Patricia Soblechero-Martín, and Virginia Arechavala-Gomeza 15. Generation of Human iPSC-Derived Myotubes to Investigate RNA-Based Therapies In Vitro Pablo Herrero-Hernandez, Atze J. Bergsma, and W.W.M. Pim Pijnappel 16. Eye on a Dish Models to Evaluate Splicing Modulation Kwan-Leong Hau, Amelia Lane, Rosellina Guarascio, and Michael E. Cheetham 17. Establishment of In Vitro Brain Models for AON Delivery Elena Daoutsali and Ronald A.M. Buijsen Part IV: In Vivo Model Systems 18. Considerations for Generating Humanized Mouse Models to Test Efficacy of Antisense Oligonucleotides Irene Vázquez-Domínguez and Alejandro Garanto 19. Generation of Humanized Zebrafish Models for the In Vivo Assessment of Antisense Oligonucleotide-Based Splice Modulation Therapies Renske Schellens, Erik de Vrieze, Ralph Slijkerman, Hannie Kremer, and Erwin van Wijk 20. Use of Small Animal Models for Duchenne and Parameters to Assess Efficiency upon Antisense Treatment Ngoc Lu-Nguyen, Alberto Malerba, and Linda Popplewell 21. In Vivo Models for the Evaluation of Antisense Oligonucleotides in Skin Jeroen Bremer and Peter C. van den Akker 22. Delivery of Antisense Oligonucleotides to the Mouse Retina Alejandro Garanto 23. Delivery of Antisense Oligonucleotides to the Mouse Brain by Intracerebroventricular Injections Tom Metz, Elsa C. Kuijper, and Willeke M.C. van Roon-Mom 24. Intrathecal Delivery of Therapeutic Oligonucleotides for Potent Modulation of Gene Expression in the Central Nervous System Zachary Kennedy, James W. Gilbert, and Bruno M.D.C. Godinho Part V: Safety and Toxicology 25. Preclinical Safety Assessment of Therapeutic Oligonucleotides Patrik Andersson 26. Preclinical Evaluation of the Renal Toxicity of Oligonucleotide Therapeutics in Mice Lucía Echevarría and Aurelie Goyenvalle 27. Protocol for Isolation and Culture of Mouse Hepatocytes (HCs), Kupffer Cells (KCs), and Liver Sinusoidal Endothelial Cells (LSECs) in Analyses of Hepatic Drug Distribution Kjetil Elvevold, Ingelin Kyrrestad, Karen Kristine Sørensen, and Bård Smedsrød Part VI: Intellectual Property 28. Patent Considerations When Embarking on New Antisense Drug Programs Laurence D.S. Gainey

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Book SynopsisINTEGRATION OF BIOMATERIALS FOR GENE THERAPY Brings industrial practitioners and researchers together to discuss how the deeper integration of biomaterial platforms could play a significant role in enabling breakthroughs in the application of gene editing for the treatment of human disease. This book comprises research and review articles from leading researchers with multidisciplinary experience. It discusses many broad topics, including nanoparticle-enabled gene therapy, inorganic nanocarrier-based gene delivery, non-viral delivery of nucleic acid, biocompatible hydrogels, silk, and polysaccharides-based gene delivery. Other gene delivery topics discussed include the use of smart and engineered biomaterials, combined therapy with growth factors and cell transportation, and the prospects and challenges in the treatment of different diseases, including cancer. This book bridges the knowledge of pharmaceutics, engineering, basic science, and clinical research fields in a way that will hTable of ContentsForeword xvii Preface xix Acknowledgment xxi 1 Biocompatible Hydrogels for Gene Therapy: Advancement and Applications 1Ankita Gupta and Swatantra K.S. Kushwaha 1.1 Introduction 2 1.2 Hydrogels Classification 3 1.3 Fabrication of Hydrogels and Its Desirable Technical Features 4 1.4 Factors to be Tuned for Gene Encapsulation in Hydrogels 4 1.5 Recent Advances on Hydrogels for Gene Delivery 6 1.6 Conclusion 9 2 Use of Polysaccharides: Novel Delivery System for Genetic Material 13Prashant Kumar, Swatantra K.S. Kushwaha, Neelottama Kushwaha, Abhishek Singh and Surya Nath Pandey 2.1 Introduction 14 2.2 Cross-Linking Techniques for Engineering Polysaccharides-Based Biomaterials 23 2.3 Approaches to Design Polysaccharide-Derived Biomaterials 26 2.4 Biomedical Applications of Polysaccharide-Derived Biomaterials 29 2.5 Advanced Biomaterials for Wound Dressings 30 2.6 Scaffolds for Tissue Engineering and Development of Bioinks for 3D Bioprinting 30 2.7 Recent Utilization of Polysaccharides 31 2.8 Toxicity Concerns of Polysaccharide-Derived Biomaterials 33 2.9 Preclinical and Clinical Studies on Gene Delivery Using Polysaccharide-Based Biomaterials 33 2.10 Challenges and Future Directions 34 2.11 Future Prospects 35 2.12 Conclusion 35 3 Polysaccharide-Based Biomaterials for Gene Delivery 47Ankita Moharana, Abhitav Tiwari, Shalini Perada, Shivlal Yadav and Om Prakash Kumar 3.1 Background 48 3.2 Introduction 49 3.3 Gene Therapy 51 3.4 Gene Delivery Systems Based on Polysaccharides 53 3.5 Practical Application of Gene Delivery Systems 56 3.6 Polysaccharide-Based Nanoparticles 57 3.7 DNA Delivery 63 3.7.1 siRNA Delivery 65 3.8 Conclusion 70 4 Hydrogel-Based Gene Therapy 77Shweta Kumari, Dipti Jena, Vedant Kumar Prajapati, Shashi Ranjan Singh and Garima Tripathi 4.1 Introduction 78 4.2 Gene Therapy 83 4.3 In Vivo Gene Therapy Using Hydrogels 86 4.4 Encapsulating Cells in Hydrogels for Gene Therapy Delivery 87 4.5 Hydrogels for Integrative Tissue Engineering and Cell Delivery 89 4.6 Biocompatible Hydrogels for Transferring Cells 91 4.7 Using Hydrogels for Gene Therapy in Tissue Engineering-Based Drug 93 4.8 Human Gene Therapy that Uses Hydrogel as an Alternative Method of Delivering Genetic Material to Patients 94 4.9 Recent Advancement in Biocompatible Hydrogel 96 4.10 Applications of Hydrogel 99 4.11 Current Hydrogels in Clinical Trials 104 4.12 Conclusions 106 5 Progress and Prospects for Non-Viral Gene Therapy 117Shashimala Tiwari 5.1 Introduction 118 5.2 Definition 118 5.3 Technology Overview for Non-Viral Gene Delivery 119 5.4 Chemical Carriers for Gene Transfer: Establishing Effective In Vivo Gene Delivery 121 5.5 Types of Gene Delivery 122 5.6 Reduction of Immunological Responses Through Alteration of Delivery Method or DNA Structure 124 5.7 To Enable Long-Lasting Gene Expression, Self-Replicating, Tissue-Specific, and Integrating Plasmid Expression Systems are Designed 124 5.8 Hybrid Vector Systems to Improve Transfection and Lessen Cytotoxicity 125 5.9 Vehicle Material 127 5.10 Further Effects 129 5.11 Challenges and Prospects 130 5.12 Conclusion 132 6 Nanoparticles for Tumor Gene Therapy: Recent Advances and Perspective 139R. Shivhare, V. Sabale, A. Ingole and Neelam Jain 6.1 Introduction 140 6.2 Technologies for Gene Delivery 142 6.3 Cancer Treatment with Gene Therapy 147 6.4 Gene Therapy Using Nanotechnology 147 6.5 Challenges and Future Aspects 160 7 Effective Gene Transfer with Non-Viral Vectors 183Anil Kumar Mavi, Sonal Gaur, Neelesh Kumar, Avanish Kumar Shrivastav, Sankha Bhattacharya,Sateesh Belemkar, Saurabh Maru and Dhruv Kumar 7.1 Introduction 184 7.2 System Development for Delivering Genes 186 7.3 Methods for Non-Viral Vector for Delivery of Genes 186 7.4 Delivery System 203 7.5 Current Methods for Nonviral Gene Delivery: Benefits and Drawbacks 209 7.6 Current Barriers for Non-Viral Vectors 210 7.7 Possibilities for Enhancing the Non-Viral Vector Delivery System 212 7.8 Conclusion 212 7.9 Future Relevance 213 8 Utilization of Chitosan for Gene Delivery 223Johnson Olaleye Oladele 8.1 Introduction 224 8.2 Cationic Polymers-Based Gene Delivery Systems 225 8.3 Chitosan and Its Derivatives in Gene Delivery Systems 228 8.4 Chitosan as Chemotherapeutic Drugs 234 8.5 Conclusion 236 9 Nanoparticles as Gene Vectors in Tumor Therapy 247 Efstathia Triantafyllopoulou, Orestis Kontogiannis, Nefeli Lagopati, Natassa Pippa and Maria Gazouli 9.1 Introduction 248 9.2 Polymer-Based Nanocarriers: Their Technology and Recent Advances 249 9.3 Conclusions 271 10 Progress in Non-Viral Delivery of Nucleic Acid: Advancement in Biomedical Technology 281Anil Kumar Mavi, Manmohan Kumar, Amarjeet Singh, Mahendra Kumar Prajapati, Rakhi Khabiya, Saurabh Maru and Dhruv Kumar 10.1 Introduction 282 10.2 Physical Methods of Non-Viral Nucleic Acid Delivery System 285 10.3 Advantages and Disadvantages of Physical Transfection 296 10.4 Chemical Methods of Non-Viral Nucleic Acid Delivery System 296 10.5 Advantages and Disadvantages of Chemical Transfection 308 10.6 Cellular Barriers for Nucleic Acid Delivery Faced by Non-Viral Vectors 309 10.7 Challenges and Limitations of Non-Viral Nucleic Acid Delivery System 311 10.8 Conclusion 311 11 The Junction of Biomaterials and Gene Therapy -- Current Strategies and Future Directions 323Ranjan Kumar Singh, Sunita Panchawat, Chennu M.M. Prasada Rao, Joohee Pradhan, Rajeswari Tanniru, Deepika Bairagee and Ajay Kumar Garg 11.1 Introduction 324 11.2 Viral Gene Therapy 327 11.3.1 Adenoviral Vectors 329 11.4 Adeno-Associated Viral Vectors 330 11.5 Non-Viral Gene Therapy 331 11.6 Recent Advances in the Development of Gene Delivery Systems 334 11.7 Development of Gene Delivery Systems 335 11.8 Viral Vectors Based on DNA for Gene Delivery Systems 336 11.9 Viral Vectors Based on RNA for Gene Delivery Systems 337 11.10 Oncolytic Viral Vectors for Gene Delivery Systems 337 11.11 Practical Application of Gene Delivery Methods 343 11.12 Conclusion 347 12 Utilization of Silk for Gene Delivery 349Swatantra K. S. Kushwaha, Shruti Khare and Neelottama Kushwaha 12.1 Introduction 350 12.2 Dimensional Structure of Silk 350 12.3 Properties of Silk 351 12.4 Extraction of Fibroin from Silk Worm 352 12.5 Fabrication of Silk in Different Therapeutics Carriers 353 12.6 Utilization of Silk for Gene Therapy 354 12.7 Properties of Silk Fibroin as Biomaterial 355 12.8 Summary of Silk-Based Formulations for Gene Delivery 357 12.9 Examples of Some Delivery Approaches which Utilizes Silk as a Biomaterial for Gene Delivery 358 12.10 Some Highlights of Silk Fibroin 360 12.11 Conclusion 360 13 Challenges and Emerging Problems in Nanomedicine Mediated Gene Therapy 367Shalini Bhatt, Neha Faridi, Rakshit Pathak, Vinay Deep Punetha and Mayank Punetha 13.1 Introduction 368 13.2 Why Nanomedicine Over Traditional Drugs? 369 13.3 Nanomedicine for Gene Therapy 373 13.4 Complications in Nanomedicine-Mediated Gene Therapy 384 13.5 Challenges in the Clinical Translation of Nanomedicines 391 13.6 Conclusion 396 14 Biomaterials-Based Vaccination in Cancer Therapy 417Rishav Sharma, Rishabha Malviya and Sonali Sundram 14.1 Introduction 417 14.2 Tumor-Associated Antigens 418 14.3 Vaccine Delivery 419 14.4 Dendritic Cells 420 14.5 In Vitro Generation of Dendritic Cells 421 14.6 Usage of RNA 422 14.7 RNA-Pulsed DCs as Vaccines 422 14.8 RNA Vaccines 425 14.9 Optimization of Immunotherapy 426 14.10 Cancer Treatment Through RNA Interference 427 14.11 Conclusion 428 References 429 Index 435

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Book SynopsisCollagen: Structure and Mechanics provides a cohesive introduction to this biological macromolecule and its many applications in biomaterials and tissue engineering. Graduate students and postdoctoral researchers in the fields of materials, (bio-)engineering, physics, chemistry and biology will gain an understanding of the structure and mechanical behavior of type I collagen and collagen-based tissues in vertebrates, across all length scales from the molecular (nano) to the organ (macro) level. Written in a clear and didactic manner, this volume includes current knowledge on the hierarchical structure, mechanical properties, in addition to a review of deformation and strengthening mechanisms. Collagen: Structure and Mechanics is an excellent reference for new researchers entering this areaand serves as a basis for lecturing in the interdisciplinary field of biological materials science.Table of ContentsCollagen: Structure and Mechanics, an Introduction.- Collagen Diversity, Synthesis and Assembly.- Collagen Fibrillar Structure and Hierarchies.- Restraining Cross-Links Responsible for the Mechanical Properties of Collagen Fibers: Natural and Artificial.- Damage and Fatigue.- Viscoelasticity, Energy Storage and Transmission and Dissipation by Extracellular Matrices in Vertebrates.- Nanoscale Deformation Mechanisms in Collagen.- Hierarchical Nanomechanics of Collagen Fibrils: Atomistic and Molecular Modeling.- Mechanical Adaptation and Tissue Remodeling.- Tendons and Ligaments: Structure, Mechanical Behavior and Biological Function.- Collagen in Arterial Walls: Biomechanical Aspects.- The Extracellular Matrix of Skeletal and Cardiac Muscle.- The Cornea and Sclera.- Collagen and the Mechanical Properties of Bone and Calcified Cartilage.- Dentin.- Genetic Collagen Diseases: Influence of Collagen Mutations on Structure and Mechanical Behavior.- Biomimetic Collagen Tissues: Collagenous Tissue Engineering and Other Applications.

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Book SynopsisElastomeric proteins are ubiquitous in nature, where they have evolved precise structures and properties that are necessary to perform specific biological roles and functions. This book emphasizes the impact of amino acid sequence on modulating protein structure, properties, and function. Examples include conformational ensemble dynamics, environmental responsiveness, self-assembly, physico-mechanical properties, morphology, and properties tailored for biomedical applications. This foundational framework is not only critical to advance scientific understanding and knowledge on elastomeric proteins but also enables the conceptualization, rational design, and development of biosynthetic elastomers and their analogous polypeptides for a variety of applications. Edited and contributed by pioneering researchers in the field, the book provides a timely overview of the materials, along with the synthesis techniques, the unique characteristics of elastomeric proteins, and biomedical and industrial applications. The book will provide a reference for graduate students and researchers interested in designing biomimetic proteins tailored for various functions.Table of ContentsBiomimetic Protein-based Elastomers: Emerging Materials for the Future; Native Resilin: Properties, Occurrence and Biological Functions of a Remarkable Bio-elastomer; Design and Production of Chimeric Resilin-like Polypeptides (RLPs); Intrinsically Disordered and Resilin-based Protein Polymers for High-performance Biomaterials Applications; Resilin-mimetic Polypeptides and Elastometic Modular Protein Polymers: Amino Acid Sequence, Conformational Ensemble, and Stimuli Responsiveness; Advanced Biomedical Applications of Self-assembled Elastin-like Recombinamer Structures; Smart Nanofibrous Materials for Tissue Engineering; Biomimetic Adhesives for Clinical Application; Silk-elastin-like Protein-based Polymers for Controlled Delivery Applications; Processing and Properties of Regenerated Bombyx mori Silk and Recombinant Spider Silk Based Fibres; Protein, Biomimetic Protein and Designer Protein-directed Synthesis of Metal Nanoparticles, Metal Nanoclustres and Nanobioconjugates and Their Potential Applications

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Book SynopsisHuman pluripotent stem cells (hPSCs), which cover both human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), show promise for drug discovery and regenerative medicine applications. These stem cells cannot be cultured on conventional tissue culture dishes but on biomaterials that have specific interactions with the hPSCs. Differentiation is regulated by the biological and physical cues conferred by the biomaterial. This book provides a systematic treatment of these topics bridging the gap between fundamental biomaterials research of stem cells and their use in clinical trials. The author looks at hPSC culture on a range of biomaterial substrates. Differentiation and control of hESCs and iPSCs into cardiomyocytes, osteoblasts, neural lineages and hepatocytes are covered. The author then considers their translation into stem cell therapies and looks at clinical trials across spinal cord injury, macular degeneration, bone disease and myocardial infarction. Finally, a chapter on future directions closes the book. By using this book, the reader will gain a robust overview of current research and a clearer understanding of the status of clinical trials for stem cell therapies.Table of ContentsIntroduction; Adult Stem Cell Culture on Extracellular Matrices and Natural Biopolymers; Feeder-free and Xeno-free Culture of Human Pluripotent Stem Cells on Biomaterials; Differentiation Fates of Human ES and iPS Cells Guided by Physical Cues of Biomaterials; Biomaterial Control of Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells; Clinical Trials of Stem Cell Therapies Using Biomaterials; Conclusions and Future Perspective on Biomaterial Control of Therapeutic Stem Cells

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Book SynopsisThe extracellular matrix (ECM) supports cells and regulates various cellular functions in our body. The native ECM promises to provide an excellent scaffold for regenerative medicine. In order to use the ECM as a scaffold in medicine, its cellular fractions need to be removed while retaining its structural and compositional properties. This process is called decellularization, and the resulting product is known as the decellularized extracellular matrix (dECM). This book focuses on the sources of dECM and its preparation, characterization techniques, fabrication, and applications in regenerative medicine and biological studies. Using this book, the reader will gain a good foundation in the field of ECM decellularization complemented with a broad overview of dECM characterization, ranging from structural observation and compositional assessment to immune responses against dECM and applications, ranging from microfabrication and 3D-printing to the application of tissue-derived dECM in vascular grafts and corneal tissue engineering etc. The book closes with a section dedicated to cultured cell dECM, a complementary technique of tissue-derived dECM preparation, for application in tissue engineering and regenerative medicine, addressing its use in stem cell differentiation and how it can help in the study of the tumor microenvironment as well as in clinical trials of peripheral nerve regeneration.Table of ContentsExtracellular Matrix Scaffolds for Tissue Engineering and Biological Research; Preparation Methods for Tissue/Organ-derived dECMs – Effects on Cell Removal and ECM Changes; Preparation of Cultured Cell-derived Decellularized Matrix (dECM) – Factors Influencing dECM Formation and Its Ability; Bared Basement Membrane Substrata: Design, Cellular Assembly, Decellularization and Application to Tissue Regeneration and Stem Cell Differentiation; A Novel Treatment for Giant Congenital Melanocytic Nevi Combining Inactivated Nevus Tissue by Pressurization and Cultured Epidermal Autograft; Immune Responses to Decellularized Matrices; Decellularized Extracellular Matrix Hydrogels: Fabrication, Properties, Characterization, and Current Applications; Decellularized Extracellular Matrix as Bioink for 3D-Bioprinting; Mechanical Property Tunable dECM and Their Regenerative Applications; Use of Small Intestinal Submucosa dECM in Tissue Engineering and Regenerative Medicine; Small-diameter Acellular Vascular Grafts: From Basic Research to Clinical Application; Decellularized Matrix for Corneal Tissue Engineering: Recent Advances in Development and Clinical Potential; Engineering an Endocrine Neo-Pancreas; Decellularized Cell-Secreted Matrices: Novel Materials for Superior Stem Cell Expansion and Tissue Engineering; Decellularized Extracellular Matrix for the Regulation of Stem Cell Differentiation; Fibroblastic Cell-Derived Extracellular Matrices: A Cell Culturing System to Model Key Aspects of the Tumor Microenvironment; Extracellular Matrix in Peripheral Nerve Regeneration

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Book SynopsisCarbon nanostructures, namely fullerenes, single and multiwall carbon nanotubes, graphene as well as the most recent graphene quantum dots and carbon nanodots, have experienced a tremendous progress along the last two decades in terms of the knowledge acquired on their chemical and physical properties. These insights have enabled their increasing use in biomedical applications, from scaffolds to devices. Edited by renowned experts in the subject, this book collects and delineates the most notable advances within the growing field surrounding carbon nanostructures for biomedical purposes. Exploration ranges from fundamentals around classifications to toxicity, biocompatibility and the immune response. Modified nanocarbon-based materials and emergent classes, such as carbon dots and nanohorns are discussed, with chapters devoted from carriers for drug delivery and inhibitors of emergent viruses infection, to applications across imaging, biosensors, tissue scaffolding and biotechnology. The book will provide a valuable reference resource and will extensively benefit researchers and professionals working across the fields of chemistry, materials science, and biomedical and chemical engineering.Table of ContentsCarbon Nanostructures: Drug Delivery and Beyond; Carbon Nanomaterials as Carriers of Anti-Inflammatory Drugs; Multivalent Glycosylated Carbon Nanostructures: Efficient Inhibitors of Emergent Viruses Infection; Carbon Nanostructures and Polysaccharides for Biomedical Materials; Biological Applications of Magnetically Empowered Carbon Nanotubes; Carbon Nanomaterials for Neuronal Tissue Engineering; Carbon Nanotubes for Cardiac Applications; Nanodiamonds and their Biological Applications; Carbon Nanomaterials for the Development of Biosensors for Microbe Detection and Diagnosis; Biotechnology Applications of Nanocarbons in Plant and Algal Systems

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Book SynopsisDynamic soft materials that have the ability to expand and contract, change stiffness, self-heal or dissolve in response to environmental changes, are of great interest in applications ranging from biosensing and drug delivery to soft robotics and tissue engineering. This book covers the state-of-the-art and current trends in the very active and exciting field of bioinspired soft matter, its fundamentals and comprehension from the structural-property point of view, as well as materials and cutting-edge technologies that enable their design, fabrication, advanced characterization and underpin their biomedical applications. The book contents are supported by illustrated examples, schemes, and figures, offering a comprehensive and thorough overview of key aspects of soft matter. The book will provide a trusted resource for undergraduate and graduate students and will extensively benefit researchers and professionals working across the fields of chemistry, biochemistry, polymer chemistry, materials science and engineering, nanosciences, nanotechnologies, nanomedicine, biomedical engineering and medical sciences.Table of ContentsThe Mutable Collagenous Tissue of Echinoderms: From Biology to Biomedical Applications; Synchrotron X-ray Imaging Combined with Multiscale Modeling Applied to Biological Soft Tissues; Biomimetic and Collagen-based Biomaterials for Biomedical Applications; Silk Fibroin-based Soft Biomaterial/Scaffolds for Tissue Engineering Strategies; Protein Aggregation Suppression and Folding Promotion by Synthetic Molecules; Levan Polysaccharide for Biomedical Applications; Alginate Particulate Gels for Oral Drug Delivery; Extending the Functionality of Marine-origin Polysaccharides Through Chemical Modification for Biomedical Applications; Elastin-like Recombinamers (ELRs) for Biomedical Applications; Minimalistic Peptide Self-assembly into Supramolecular Biomaterials; Recent Advances in the Design of Surface-initiated Polymer Brushes for Biomedical Applications; Bioinspired and Bioinstructive Surfaces to Control Mesenchymal Stem Cells; Biomimetic Surface Modifications of Biomaterials Using a Layer-by-layer Technique; Smart Porous Silica–Polymer Nanomaterials for Theranostics; Liposomes for Biomedical Applications; Cyclodextrin-based Drug Delivery Systems Manufactured by Emergent Technologies: 3D-printing, Electrospinning, Microneedles, Microfluidics and MOFs; Soft Fibrillar Biomaterials by Fibre Spinning Routes; Shaping Soft Structures Using Bottom-up Layer-by-layer Assembly Technology for Biomedical Applications; Nanobiomaterials for Smart Delivery; Liposomes in Targeted Drug Delivery; Polysaccharide-based Hydrogels for the Controlled Delivery of Therapeutic Biomacromolecules; Stimuli-responsive Drug Delivery Hydrogels; Stimuli-responsive Nanocomposite Hydrogels Incorporating Soft Nanoparticles for Biomedical Applications; 3D-printed Soft Hydrogels for Cell Encapsulation; Decellularized Matrix Hydrogels for In Vitro Disease Modeling; Animal Protein-based Soft Materials for Tissue Engineering Applications; Soft Robotics Solutions for Minimally Invasive Surgery: The Need for Stiffness Controllability; Cell-based Soft Biomaterials

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Book SynopsisSilk proteins show excellent biocompatibility, controllable biodegradability and non-immunogenicity, and as such are studied extensively worldwide for biomedical applications. In particular, there is increasing interest in their use for drug delivery systems. This focussed book on silk proteins for drug delivery systems, delves into a key emerging area to outline the concepts and define the field. Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin. Showing how these proteins are employed in micro and nano drug delivery systems, their use in pre-clinical and clinical trials, and closing with chapter on sustainability- driven innovation in the pharma industry, this book is ideal for graduates and researchers in biomaterials science and pharmaceutical science.Table of ContentsMicro and Nano-Drug Delivery Systems; The Silk; Silk-Fibroin Micro-Drug Delivery Systems; Silk-Fibroin Nano-Drug Delivery Systems; Silk-Sericin Micro-Drug Delivery Systems; Silk-Sericin Nano-Drug Delivery Systems; Physico-Chemical Characterisation of Silk-Based Materials; From Bench to Bedside: the Long Way Towards GMP Scale-Up, Preclinical and Clinical Trials for Silk-Based Drug Delivery Systems; From Textile to Pharmaceutical and Cosmetic Industry: Circular Economy Applied to Silk Manufacturing Wastes

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Book SynopsisHydrogels represent one of the cornerstones in tissue engineering and regenerative medicine, due to their biocompatibility and physiologically relevant properties. These inherent characteristics mean that they can be widely exploited as bioinks in 3D bioprinting for tissue engineering applications as well as injectable gels for cell therapy and drug delivery purposes. The research in these fields is booming and this book provides the reader with a terrific introduction to the burgeoning field of injectable hydrogel design, bioprinting and tissue engineering. Edited by three leaders in the field, users of this book will learn about different classes of hydrogels, properties and synthesis strategies to produce bioinks. A section devoted to the key processing and design challenges at the hydrogel/3D bioprinting/tissue interface is also covered. The final section of the book closes with pertinent clinical applications. Tightly edited, the reader will find this book to be a coherent resource to learn from. It will appeal to those working across biomaterials science, chemical and biomedical engineering, tissue engineering and regenerative medicine.Table of ContentsOverview of Injectable Hydrogels for 3D Bioprinting and Tissue Regeneration; Introduction to Hydrogel Synthesis and Crosslinking Methods for Developing Bioinks for 3D Bioprinting; Characterizations of Hydrogels; Naturally Occurring and Nature-derived Polymers as Injectable Hydrogels; Self-assembling Hydrogels Based on Natural Building Blocks; In Situ Forming Hydrogels; Injectable Biopolymer Hydrogels for Regenerative Medicine; Introduction to 3D Bioprinting of Injectable Hydrogels; Hydrogel Processing Techniques and Vascular Tissue Engineering; Rheological Aspects of Hydrogel Processing; Interface (Cell, Gel, Surface) and Biocompatibility in Gel Processing; Bioprinting Hydrogels and Tissue Engineering; 3D Bioprinting Hydrogel for Hard Tissue Regeneration; 3D-bioprinting for Engineering Complex Tissues and Vascularization; Hydrogels–Blood Interactions; Immuno-response and Hydrogels; Application of Natural Hydrogels for Cell Therapy: Focus on Osteoarthritis; Clinical Application and Regulation of Bioprinting Biomaterials Focusing on Hydrogels; Status for Commercialization of FDA-approved Hydrogels and Their Intellectual Properties

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Book SynopsisExtracellular and biofluids vesicles (EVs) are highly specialised yet ubiquitous nanoscale messengers secreted by cells. With the development of stem cell engineering, EVs promise to deliver next generation tools in regenerative medicine and tissue engineering, as well as in diagnostics. A vibrant and promising field, this book provides the first resource to the field. Covering basic cell biology, including EV production and intracellular communication, this book will provide material scientists and engineers with a foundation to the necessary biology. The reader will then learn about the isolation of extracellular vesicles their physicochemical characterisation and therapeutic application of EVs in regenerative medicine as well as their potential as biomarkers in medical diagnostic. This book will also discuss the regulatory landscape of EVs. Bridging cell biology, biomaterials, biophysics and biomedical engineering the content of this book is written with a broad interdisciplinary audience in mind. Researchers, new and established will find this a must-have on their shelf.Table of ContentsTherapeutic Potential of Mesenchymal Stromal Cell-derived Small Extracellular Vesicles; Separation and Purification of Extracellular and Bio-fluid Vesicles - State of the Art: Past, Present, and Future of Extracellular Vesicle Separation and Purification; Physicochemical Characterisation of Extracellular Vesicles; Biological Characterization of Extracellular Vesicles - Methodologies to Characterize Molecular Composition of Extracellular Vesicles - Advances Towards Single Vesicle Characterization; Extracellular Vesicles in Bone Tissue Engineering; Mesenchymal Stromal Cell (MSC)-derived Small Extracellular Vesicles as Next-generation Therapeutics for Cartilage Regeneration; The Role of Extracellular Vesicles in the Neuronal System: Application of Extracellular Vesicles in Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, and Dementia; The Role of Extracellular Vesicles in Aging of the Human Placenta; Extracellular Vesicles in Lung Diseases; Immunomodulatory Function of Extracellular Vesicles in Cancer and Tissue Repair/Regeneration; Diagnostic Applications of Extracellular and Bio-fluid Vesicles; Standardization and Commercialization of Extracellular Vesicles

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Book SynopsisInorganic glasses are successfully used in the biomedical field, in particular degradable glasses have found applications in tissue engineering, bone regeneration and tooth remineralisation. Silicate glasses are the most commonly used ones but phosphate and borate glasses are attracting more and more interest owing to their special properties, differing from those of silicate bio-glasses. Phosphate and borate glasses thus open up potential routes for new therapeutic applications. This book focuses on these emerging materials. Bridging the phosphate and borate glasses communities, this book provides a fundamental treatment of atomic structure and physicochemical properties before highlighting their current and potential future applications. Phosphate and borate glasses not only feature a broader range of glass formation than silicate glasses. Their ability to completely dissolve in water with the solubility varying over orders of magnitude with compositional changes, makes them exciting materials for delivering therapeutic agents into the human body. Biomaterials scientists working in glasses, hard tissue engineering and regenerative medicine will find this a must-have book to own, alongside their more traditional silicate glass tomes.Table of ContentsUnique Nature of Phosphate and Borate Bioactive Glasses; Structure and Thermal Properties of Phosphate Glasses; Dissolution Behaviour of Phosphate Glasses; The Role of Phosphate Glasses in Bone Regeneration Remedies; Calcium Phosphate Invert Glasses; Phosphate-based Glasses Prepared via Sol–Gel and Coacervation; Amorphous Calcium Phosphate Coatings; Phosphate Glasses for Biophotonic Applications; Structure and Properties of Borate Glasses; Reactions of Borate Glasses in Aqueous Solutions; Sol–Gel Borate Glasses; Recent Advances in the Development and Applications of Phosphate and Borate Glass Microspheres; Borophosphate Glasses and Their Potential Use in Medical Devices; Clinical Products and Further Devices of Phosphates and Borates

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Book SynopsisMechanobiology is a new research field that investigates how the physical forces and changes in mechanical properties of cells and tissues contribute to their development, physiology and disease. One unique feature in the mechanical regulation, distinct from chemical/biochemical one, is that it can directly react with the multi-layered architectures of living systems, ranging from nano-scale proteins, subcellular organelles, cells, tissues, organs to whole bodies; one could term it “mechanoarchitectonics”. Another important aspect is its time-dependent dynamic feature. Not only time evolution in cells and extracellular matrices, but their intrinsic viscoelastic nature makes mechanical interaction dissipative and such feature is critical in cellular mechanical responses. This book focuses on recent progress in mechanobiology from the materials science perspective, encompassing innovative material designs for force measurements and actuation to resolve dynamic mechanobiology and mechanoarchitectonics, by better mimicking physiologically relevant and time-evolving cellular mechanical environments. It also shows the marriage between cutting-edge materials science which enable spatiotemporal manipulation of material and cell dynamics in multi-dimensions and molecular biological techniques such as genome editing and next generation sequencing for cell fate/motility engineering and disease modelling, with the aim of providing valuable insights into the latest technological advances and discoveries in areas such as stem cell, fibroblast, heart, tumour, and epithelial mechanobiology. Edited by leaders in the field, this book will be suitable for a broad range of readers, including materials scientists, biomaterial and biomedical engineering researchers and those working in chemical and mechanical engineering to expand possibilities of system designs for the developments of medical technologies based on mechanobiology.Table of ContentsAn Introduction to Material-based Mechanobiology;On the Molecular Basis of Cellular Mechanobiology;Mechanotransduction at the Cell Surface and Methods to Study Receptor Forces;Measurement and Manipulation of Cellular Forces Using Silicone Elastomers;Geometric Cues for Directing Cell Fate;Dynamic Interfaces for Mechanobiological Studies;Micro- and Nanopatterned Substrates for Studies on the Mechanobiology of Cell–Matrix Adhesions;Role of Topographic Cues in Engineering the Muscle Niche;Engineered Substrate with Dynamically Tunable Topography;Curvature Mechanobiology;Dynamic Hydrogel;Manipulation of Durotaxis on a Matrix with Cell-scale Stiffness Heterogeneity;Engineered 3D Matrices with Spatiotemporally Tunable Properties;Combining Genetic and Mechanical Factors to Model Disease

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Book SynopsisThe tumour microenvironment is increasingly recognized as an important contributor to cancer progression and treatment. However, most cancer studies continue to be performed in 2D tissue culture dishes that do not capture the characteristics of the tumour niche. This book provides an introduction to the rich chemical, topographical, and mechanical cues in the tumour microenvironment and then introduces readers to bioengineering strategies, including scaffold design and synthesis, chemical signalling and delivery, and co-culture, microfluidics, and organ-on-a-chip tools that can be used to mimic tumour microenvironment features. This book also includes discussion of emerging imaging methods compatible with tumour microenvironment mimicking biomaterials and discusses applications of such models in immuno-oncology, metastasis, and drug screening. Edited by two leaders in the field, this book will appeal to graduate students and researchers working in biomaterials science, chemical and biomedical engineering departments.Table of ContentsTissue Engineering Models for Cancer Pathology;Introduction to the Tumor Microenvironment;Mimicking Fibrous Topographical Features of the Tumor Microenvironment;Mimicking Mechanical Features of the Tumor Microenvironment;Mimicking Chemical Features of the Tumor Microenvironment;Mimicking Multicellular Features of the Tumour Microenvironment;Cell Patterning to Mimic Tumor Anatomy;Advanced Scaffold Design via Electrospinning;Advanced Scaffold Fabrication using Additive Manufacturing;Microfluidic Models of the Tumour Microenvironment;Modeling of the Tumor Microenvironment in Tumor Organoids;Imaging in Scaffolds;The Intersection of Biomaterials,Tissue Engineering and Immuno-oncology;Tissue Engineered Models of Metastasis: Focus on Bone Metastasis;Tissue-engineered Cancer Models in Drug Screening

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Book SynopsisPolysaccharides are natural, renewable materials that are biodegradable and biocompatible, making them ideal subjects for biomedical applications. This book focusses on the main polysaccharides, including but not limited to chitosan, cellulose, alginate, dextran, guar gum, gellan gum, pullulan, locust bean gum, pectin, xanthan gum, starch, hyaluronan and carrageenan, and their applications in drug delivery, imaging and tissue engineering. With contributions from around the world, the editors have pulled together a tightly curated set of chapters which showcase how polysaccharide-based materials are employed in a range of biomedical systems. The end result is a book in which the reader can gain a sound overview of this important class of material for biomedical applications, without scouring journal articles. Those working in materials science, biomedical and chemical engineering, and pharmaceutical technologies will find this a must-have reference.Table of ContentsPolysaccharide-based Biomaterials: Overview;Recent Approaches in Alginate-based Carriers for Delivery of Therapeutics and Biomedicine;Alginate-based Carriers for Transdermal Drug Delivery;Chitosan-based Nanocarriers for Drug Delivery: Advances and Challenges;Hyaluronic Acid in Drug Delivery;Dextran in Delivery of Therapeutics: Chronicle of the Journey from Preclinical to Clinical Trials;Guar Gum-based Biomaterials in Delivery of Therapeutics;Gellan Gum-based Drug Delivery Carriers;Locust Bean Gum - A Potential Drug Delivery Carrier;Pectin-based Vehicles for Delivery of Therapeutics;Pullulan in the Delivery of Therapeutics;Carrageenan-based Carriers for Therapeutic Delivery;Xanthan Gum in Drug Carriers;Cellulose-based Biomaterials in Drug Delivery Applications;Starch-based Drug Delivery System: A Review on Pharmaceutical and Biomedical Applications;Tamarind Seed Polysaccharide in Novel Drug Delivery and Biomedical Applications;Chitosan-derived Biomaterials in Cancer Therapeutics and Biomedical Imaging;Polysaccharide-based Scaffolds for Tissue Engineering Application

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Book SynopsisThis book is a comprehensive guide to BiodentineTM, an innovative biocompatible and bioactive material based on pure tricalcium silicate that can permanently replace dentin and can also serve as a temporary enamel substitute. Although BiodentineTM has been widely used across the world for the past decade, this is the first book to be devoted to its properties, interactions with the soft and hard tissues, and its multiple clinical applications. The coverage encompasses applications in primary and permanent teeth, in specialties as diverse as restorative dentistry, endodontics, paediatric dentistry, dental traumatology, and prosthetic dentistry. BiodentineTM application both in vital pulp therapy and endodontic procedures is illustrated and clinical step by step protocols are provided. The book provides a detailed update on BiodentineTM use to preserve the pulp vitality in direct/indirect pulp capping, pulpotomy and irreversible pulpitis treatment. It also details BiodentineTM use for non-vital teeth treatment in indications such as root/furcation perforation repair, apexification as well as in regenerative endodontic procedures.BiodentineTM: Properties and Clinical Applications will be a rich source of guidance and information for all dentists as well as dental students and academics.Table of ContentsChapter 1) Biodentine Microstructure and Composition.- Chapter 2) Biodentine Physico-chemical Properties: From Interactions with Dental Tissues to Aging.- Chapter 3) Biocompatibility and Bioactive Properties of Biodentine.- Chapter 4) Biodentine in Inflammation and Pain Control.- Chapter 5) Biodentine Clinical Applications in Vital Pulp Therapy in Permanent Teeth.- Chapter 6) Biodentine: Applications in Pulpotomy of Deciduous Teeth.- Chapter 7) Biodentine Applications in Traumatology and Fractures.- Chapter 8) Biodentine Applications in Irreversible Pulpitis Management in Children and Adults.- Chapter 9) Calcium Silicate-based Cement (Biodentine TM) as a Bioactive Material for the Long-Term Preservation of Pulp Vitality in Restorative Dentistry and Prosthodontics.- Chapter 10) Biodentine Applications in Furcation Perforation and Root Resorption.- Chapter 11) Clinical Applications of Biodentine in Regenerative Endodontics/Revitalization.

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Book SynopsisThis book describes past and present advances in engineering materials for neural applications, with special emphasis on their usefulness for traumatic brain and spinal cord injuries. The book presents major physio-pathological features of traumatic injuries at the brain and spinal cord as examples of diseases hampering the central nervous tissue. By incorporating knowledge from the perspective of experts with diverse backgrounds, this book gives insight into the understanding of these multifaceted pathologies and the materials science approaches that aim to cure them. The interdisciplinary nature of this book makes it a perfect candidate for the interest of a broad audience, from clinicians working on neural diseases to scientists whose work focuses on the nervous tissue (neuroscientists) and/or materials science. Undergraduate and PhD students can also benefit from the knowledge and discussion included in this book.Table of Contents

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Book SynopsisThis book presents synthesis, characterization, and applications of macroporous, mesoporous, nanoporous, hierarchical porous, porous metals, and porous ceramics. Special emphasis is given to the preparation of porous activated carbon materials and porous ionic liquid-derived materials for CO2 emissions mitigation. Additionally, a chapter includes the physical and mathematical modeling in porous media. Many analytical techniques for characterization are discussed in this book. Also, the biomedical and industrial applications of porous materials in adsorption, catalysis, biosensors, drug delivery, nanotechnology are described. The content helps solving fundamental and applied problems in porous materials with length scales varying from macro- to nano-level. Table of Contents

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Book SynopsisThis highly illustrated textbook provides an essential overview on RNA architecture and function, it offers insights into the RNA basics and also explains novel RNA technologies, such as CRISPR-Cas and their applications. In addition, the mRNA based vaccine technology, which has long been tested, also before the COVID-19 pandemic, is discussed and students receive a basic understanding of this important medical application.The textbook is written by Prof. Grover in collaboration with her students and has an easily accessible style. The book provides a great tool for young researchers and students in biology, biomedical engineering or biochemistry, looking for a compact introduction or refresher work on RNA, including the newest findings and technologies. It is an ideal starter to learn about several RNA specific topics and to research them further.Table of Contents1. RNA-Composition and Base Pairing.- 2. Architecture of RNA.- 3. Small Catalytic RNA.- 4. The Spliceosome: A Large Catalytic RNA.- 5. A Genomic Perspective on RNA.- 6. The mRNA and the New Vaccines.- 7. Riboswitches: Sensors and Regulators.- 8. Small Non-Coding RNA, miRNA in Gene Regulation.- 9. CRISPR-Cas Systems, The science and ethics of gene manipulation.- 10. Transcription.

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Book SynopsisThis book focuses on recent advances in dental gold alloys and gold nanoparticles (GNPs) for biomedical applications. Dental gold alloys combine several highly desirable mechanical properties, such as high strength, ductility, and elasticity, with an extremely robust chemical stability in the mouth. Moreover, astonishing progress has been made in the use of GNPs as novel gold biomaterials that provide a multifunctional platform for cellular imaging, biosensing, and targeted drug delivery in tumour immunotherapy and photothermal therapy. Beginning with a comprehensive overview of the development and use of dental gold alloys, the book addresses the materials properties that are crucial for dental applications, focusing on aspects such as microstructure, chemical and mechanical stability, ageing, biocompatibility, and colour retention. The book then shifts focus to the use of GNPs in dental applications, delving into different techniques of GNP synthesis for specifically tailoring the size, shape, and stability of GNPs in biological media. In addition to these factors, it addresses how their exposure route, surface chemistry, as well as how the steric effects of their coating impact biodistribution and determine the level of GNP toxicity in the human body. Featuring topical literature reviews alongside up-to-date published experimental results, this book offers an attractive resource for practicing scientists and engineers working in the field of gold-based biomaterials.Table of Contents

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Book SynopsisThis book will serve as a one-stop, reference manual to understand the basic concepts of dental implant design, the related microbiome, research models and current concepts as well as futuristic perspectives in implant surface modification. The manual-like design including colorful illustrations and important critical questions will help researchers and advanced students in understanding the contemporary status and in designing studies for innovative treatments of dental implant infections. Considering the microbiome of dental implant related environment in health and disease is imperative to design strategies to good practice and prevention of infections around implants. This monograph will serve as a single reference material which links the interdisciplinary aspect of the dental implants covering material sciences, engineering and biological aspects, thus effectively bridging the gap between engineering and oral health sciences.Table of ContentsDental Implants – An Overview.- Oral Microbiota and Biofilm Infections.- Host Immune Response to Dental Implants.- In Vitro and In Vivo Models to Understand Dental Implant Integration.- Modern Approaches to Dental Implant Biofilm Management.- High Performance Advanced Materials.

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Book SynopsisThis book provides a holistic compilation on applications of carbon nanostructures, especially in advanced healthcare applications. It comprises chapters on utility of diverse multifunctional nanocarriers in drug delivery and biomedical applications, especially emphasizing on the synthesis and characterizations of nanosystems along with surface engineering approaches used for active targeting of the drugs. Moreover, the chapters also include the recent updates on the applications of the nanocarriers to fulfill the needs of various healthcare systems.Table of ContentsTitles Contributing author 1). Introduction to carbon nanomaterials Dr. Amit Kumar Nayak Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj-757086, Odisha, India E-mail: amitkrnayak@yahoo.co.in 2). Emergence in carbon nanotubes for drug delivery and biomedical applications Ibrahim M. El-Sherbiny, PhD, NZIC, MRS, AAPS, BMES Professor of Smart Nanomaterials & Nanomedicine, Director, Center for Materials Science (CMS), Founding Chairman, Nanoscience Program Founding Former Chairman, Materials Science Program Editor, Drug Development and Industrial Pharmacy (DDIP, USA) Editor-in-Chief, Journal of Nanotechnology & advanced Materials - Natural Sciences (USA) Vice President, National Council for New & Advanced Materials, National Council of Drug Research, HS-Board Member, National Organization for Drug Control and Research (NODCAR) Zewail City of Science and Technology Nano-Building, Room F003 Ahmed Zewail Road, October Gardens, 6th of October, 12578, Giza, Egypt Website: https://www.zewailcity.edu.eg/main/content.php?lang=en&alias=ibrahim_m._el-sherbiny e-mail: ielsherbiny@zewailcity.edu.eg 3). Graphene nanocomposites in healthcare appllications Prof. Dr. Cornelia Vasile "P.Poni" Institute of Macromolecular Chemistry Department of Physical Chemistry of Polymers 41A Grigore Ghica Voda Alley R0 700487 IASI ROMANIA e-mail: cvasile@icmpp.ro 4). Fullerenes: Bucky balls in promising therapeutic applications Prof. Sanjay K. Jain, Professor of Pharmaceutics, Head, Department of Pharmaceutical Sciences, Dr. Harisingh Gour University, Sagar (MP)-470002, India Emails: drskjainin@gmail.com, drskjainin@yahoo.com 5). Nanodiamonds as next geneation carriers in exploring therapeutic benefits Dr. Nafiu Aminu Lecturer, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, P.M.B. 2346 Sokoto, Nigeria. E-mail: nafiu.aminu@udusok.edu.ng, nabgus@yahoo.com 6). Nanographites as multidimenssional carriers for advanced therapeutic applications Dr. Wazed Ali Department of Textile and Fibre Engineering, Indian Institute of Technology Delhi, HauzKhas, New Delhi-11016, India. E-mail: wazed@textile.iitd.ac.in 7). Carbon nanohorns in drug delivery and medical applications Dr. Samuel Eshorame Sanni Department of Chemical Engineering, Covenant University, Ota, Ogun State, Nigeria E-mail: sanni@covenantuniversity.edu.ng 8). Carbon nanotorous for advanced therapeutic applications Dr. Prashant Kumar Sharma, Assistant Professor, Department of Physics, Indian Institute of Technology, (Indian School of Mines), Dhanbad 826004, India. E-mail: prashantnac@gmail.com, prashant@iitism.ac.in 9). Carbon nanobombs: Newer class of materials for multifunctional applications Dr. Mehrdad Hamidi Professor of Pharmaceutics, School of Pharmacy, Zanjan University of Medical Sciences, Iran E-mail: hamidim@zums.ac.ir 10). Bio-inspired carbon nanostructures: Advances and challenges Dr. Joash Ban Lee Tan School of Science, Monash University, Malaysia E-mail: tan.ban.lee@monash.edu 11). Functionalized carbon dots in theraputic applications Dr. Wanpen Tachaboonyakiat Department of Materials Science, Faculty of Science, Chulalongkorn University, Phayathai, Pathumwan, Bangkok 10330, Thailand. E-mail: wanpen.ta@chula.ac.th 12). Carbon quantum dots: Perspectives and Prospects Dr. Yadollah Omidi Professor of Pharmaceutical Sciences, Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, 3200 South University Drive, Davie, FL 33328, USA E-mail: yomidi@nova.edu 13). Carbon-based host-guest nanosystems in biomedical applications Dr. MiIlan MIlivojevic University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia E-mail: mmilan@tmf.bg.ac.rs 14). Carbon nanotropes with newer potential for drug delivery and biomedical applications Dr. Jaison Jeevanandam Department of Chemical Engineering, Faculty of Engineering and Sciences, Curtin University, Malaysia E-mail: jaison.jeevanandam@gmail.com 15). Carbon nanofibres in diversified healthcare applications Dr. Classius Ferreira da Silva Universidade Federal de São Paulo - UNIFESP Departamento de Engenharia Química, Laboratório de Biotecnologia e Produtos Naturais - BIONAT (3o. Andar), Brazil E-mail: classiusferreira@yahoo.com.br 16). Biosafety and toxcity evaluation of carbon nanomaterials Dr. Md Saquib Hasnain Department of Pharmacy, Shri Venkateshwara University, NH-24, Rajabpur, Gajraula, Amroha – 244236, U.P., India E-mail: msaquibhasnain@gmail.com

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Book Synopsis"Functional Materials textbook is not simply a review of the vast body of literature of the recent years, as it holds the focus upon various aspects of application. Moreover, it selects only a few topics in favor of a solid and thorough treatment of the relevant aspects. This book comes in a good time, when a large body of academic literature has been accumulated and is waiting for a critical inspection in the light of the real demands of application." Professor Gerhard Wegner, Max-Planck Institute for Polymer Research, Mainz, Germany The chapters cover three important fields in the development of functional materials: energy, environment, and biomedical applications. These topics are explained and discussed from both an experimental and a theoretical perspective. Functional organic and inorganic materials are at the center of most technological breakthroughs. Therefore, the understanding of material properties is fundamental to the development of novel functionalities and applications.Table of ContentsFrom the Contents: Preface/Introduction: - Advanced Materials Development: Moving from Structural Properties towards SpecializedFunctions Functional Materials: Synthesis and Applications - Colloids preparation and polymerization in dispersed medium - Fullerenes, graphenes and their application in functional materials - Mesoporous materials - Nanomaterials: Properties and applications - Conjugated polymers for organic electronics - Theoretical tools for the design of functional materials: From micro to macro properties Development of New Materials for Energy Applications - Materials for energy storage and conversion (batteries and supercapacitors) - Membranes development and metal-air batteries - Materials for fuel cells technologies - Ionic Liquids for Li-ion batteries New Trends in Biomaterials and Biomedical Imaging - Biocompatible polymers for medical device and implant fabrication - Functionalized nanoparticles for bioimaging and diagnostic applications - Functional polymers and intelligent fibers for biomedical applications - Silk: an inspiration for innovative biomaterials Functional Materials for Sustainable Development - Nanocellulose and other functional wood derivatives

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Book SynopsisCorrosion Science and Engineering is now an integral part of research throughout the world. Researchers are actively looking for an alternative eco-friendly way of developing non-toxic corrosion inhibitors from natural sources. This book discusses all the recent advancements in the corrosion field with an emphasis on natural sources which is the demand of the era to replace the commercially available toxic corrosion inhibitors.

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Book SynopsisThe focus of this book is to introduce up-to-date information on applications and practical use of RNA for agriculture, biotechnology and medicine. It provides unique ideas, tools, and methods in detail from a variety of scientific and technical disciplines. RNA science has progressed enormously in recent decades, and vast amounts of information on RNA functions and their regulatory mechanisms are becoming available. Such a progress opened the door to an age of practical application of RNA in many fields including agriculture, plant science, medical science, brewing and fermentation technology, and material production. This book inspires its readership and contributes to not only expansion in application of RNA but also to basic research. Table of ContentsList of titles and authors (as of 24 Aug 2016) 1. Gene expression system that can escape from translational repression caused by brewing-related stress Shingo IZAWA 2. Bacterial cellular engineering through interspecies exchange of 16S rRNA in Escherichia coli ribosome. Kentaro MIYAZAKI 3. Development and application of the excellent protein synthesis technique with riboswitches in microorganisms Takahiro YAMAUCHI and Naoki SUGIMOTO 4. Cell Reprogramming by Lactic Acid Bacteria. Kunimasa OHTA 5. Novel detection system of mycotoxin using aptamer Yuji MORITA 6. Rational design of artificial riboswitches Atsushi OGAWA 7. mRNA engineering as a tool for controlling mammalian cells in medical applications Kei ENDO and Hirohide SAITO 8. Modulation of abnormal splicing by small chemical compounds in RNA diseases Naoyuki KATAOKA 9. Protein production system by innovating mRNA export Seiji MASUDA 10. PPR protein and the engineering Takahiro NAKAMURA 11. Long noncoding RNAs and their applications Tomohiro YAMAZAKI 12. Long non-coding RNA as new diagnostic and therapeutic targets Eleonora LEUCCI 13. Riboswitches and ribozymes as RNA-based modular tools to control gene expression Yoshiya IKAWA and Shigeyoshi Matsumura 14. Applications of CRISPR/Cas9 genome editing for functional characterization of RNA helicases Jerry PELLETIER 15. Application of systemic TGS on plant breeding Songling BAI 16. Theoretical and applied epigenetics in plants Yuhya WAKASA, Taiji KAWAKATSU, and Fumio TAKAIWA

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Book SynopsisThis book provides a compendium of material properties, demonstrates several successful examples of bio-based materials’ application in building facades, and offers ideas for new designs and novel solutions. It features a state-of-the-art review, addresses the latest trends in material selection, assembling systems, and innovative functions of facades in detail. Selected case studies on buildings from diverse locations are subsequently presented to demonstrate the successful implementation of various biomaterial solutions, which defines unique architectural styles and building functions. The structures, morphologies and aesthetic impressions related to bio-based building facades are discussed from the perspective of art and innovation; essential factors influencing the performance of materials with respect to functionality and safety are also presented. Special emphasis is placed on assessing the performance of a given facade throughout the service life of a building, and after its end. The book not only provides an excellent source of technical and scientific information, but also contributes to public awareness by demonstrating the benefits to be gained from the proper use of bio-based materials in facades. As such, it will appeal to a broad audience including architects, engineers, designers and building contractors.Table of Contents

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Book SynopsisThis book provides a concise introduction to soft matter modelling, together with an up-to-date review of the continuum mechanical description of soft and biological materials, from the basics to the latest scientific materials. It also includes multi-physics descriptions, such as chemo-, thermo-, and electro-mechanical coupling. The new edition includes a new chapter on fractures as well as numerous corrections, clarifications and new solutions. Based on a graduate course taught for the past few years at Technion, it presents original explanations for a number of standard materials, and features detailed examples to complement all topics discussed.Table of Contents

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Book SynopsisThis volume provides a thorough insight into the chemistry and mechanism of ionic gelations of various ionic biopolysaccharides, like alginate, gellan gum, pectin, chitosan, carboxymethyl cellulose, etc., and the applications of various ionically gelled biopolysaccharides in drug delivery fields, with chapters emphasizing the recent advances in the field by the experts. This book will be of interest to graduate students and academic and industry researchers from pharmacy, biotechnology, bioengineering, biomedical and material sciences fields.Table of ContentsIonically gelled pectinates in drug delivery.- Ionically gelled alginates in drug delivery.- Ionically gelled gellan gum in drug delivery.- Ionically gelled chitosan in drug delivery.- Ionically gelled carboxymethyl polysaccharides in drug delivery.- Polyelectrolyte complex-based ionically gelled biopolymeric systems for sustained drug release.- Ionically gelled polysaccharide-based interpenetrating polymer network systems in drug delivery.- Ionically gelled polysaccharide-based multiple-units in drug delivery.- Ionically gelled polysaccharide-based floating drug delivery systems.

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Book SynopsisThis book provides deep insight into the significance of various forensic techniques underlying the methodical approaches in criminal investigations. The book comprises numerous case studies, examples, and reference materials. It emphasizes on the better practices for criminal investigations including contemporary examinations. The book also describes various methods for investigation of crime scene and evidence collection including biological evidences to the resources of law enforcement agencies. This book encompasses the procedure for crime scene-documentation through photography, video, and diagrams and highlights the best practices of packaging the biological evidences at a crime scene. Further, it summarizes the role of forensic autopsy to the criminal investigation system. As such, the book is helpful for forensic scientists, medical practitioners, educators and law enforcement personnel.Table of Contents1 Initial response at crime scenes and prioritization of efforts.- 2 Crime scene processing: documentation and evaluation.- 3 Crime Scene Searching: An Exploration of Forensic Evidence.- 4 Collection, Preservation and Packaging: Forensic Evidence Management.- 5 Paint, Soil and Glass Evidences: A Silent Witnesses.- 6 Questioned Document Examination: A Prevalent Dispute.- 7 Medicolegal Examination: A Guide to the Criminal Investigation System.- 8 Examination of Tampered Voice.

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Book SynopsisGene therapy has been regarded as a great potential for specific treatment of gene-related human diseases, such as cancer, genetic and epidemic diseases. Gene therapy refers to the biomedical technology that inserts normal or therapeutic exogenous genes into target cells to repair or replace defective genes in target cells, so as to achieve the purpose of treating diseases. Efficient gene delivery systems are the crucial roles for successful implementation of gene therapy. This book provides a platform for young scholars and students to systematically understand the preparation and characterization of the existing non-viral gene delivery systems, as well as providing a technology platform for clinical gene therapyTable of ContentsOverview on gene therapy.- Cationic liposome.- Functionalized peptide dendrimers.- Bioresponsive poly(amido amine)s.- Cationic polyphosphoesters.- Polysaccharide-based gene carriers.- Polypeptide-based gene carriers.- Fluorinated gene carriers.- Target gene delivery systems.- Cationic helical polypeptides.- Cyclic cationic polymers.- Cationic bolaamphiphile.- Chitosan-functionalized gene carriers.- Charge-reversal gene carriers.- Multifunctional envelope-type nanodevice.- Drug and gene co-delivery systems.- Oral delivery of gene therapy.- Gene therapy for brain diseases.

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Book SynopsisThis book comprises select papers presented at the conference on Technology Innovation in Mechanical Engineering (TIME-2021). The book discusses the latest innovation and advanced research in the diverse field of Mechanical Engineering such as materials, manufacturing processes, evaluation of materials properties for the application in automotive, aerospace, marine, locomotive and energy sectors. The topics covered include advanced metal forming, Energy Efficient systems, Material Characterization, Advanced metal forming, bending, welding & casting techniques, Composite and Polymer Manufacturing, Intermetallics, Future generation materials, Laser Based Manufacturing, High-Energy Beam Processing, Nano materials, Smart Material, Super Alloys, Powder Metallurgy and Ceramic Forming, Aerodynamics, Biological Heat & Mass Transfer, Combustion & Propulsion, Cryogenics, Fire Dynamics, Refrigeration & Air Conditioning, Sensors and Transducers, Turbulent Flows, Reactive Flows, Numerical Heat Transfer, Phase Change Materials, Micro- and Nano-scale Transport, Multi-phase Flows, Nuclear & Space Applications, Flexible Manufacturing Technology & System, Non-Traditional Machining processes, Structural Strength and Robustness, Vibration, Noise Analysis and Control, Tribology. In addition, it discusses industrial applications and cover theoretical and analytical methods, numerical simulations and experimental techniques in the area of Mechanical Engineering. The book will be helpful for academics, including graduate students and researchers, as well as professionals interested in interdisciplinary topics in the areas of materials, manufacturing, and energy sectors.Table of ContentsBeacon Based Smart Shopping System Using IoT.- Cache Memory Design Analysis for Single Bit Architecture for Core Processor.- Impact of Acoustics Impingement on Proliferating Fires.- Analytical Study of Fluid Pressure Sensing Mechanism in Microchannel for Microfluidic Device.

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Book SynopsisThis book presents recent advances in nanostructured biomaterials. It covers the structures and applications of advanced nanostructured biomaterials. The topics covered include overview on biological activities of thiazole derivatives, imidazole derivatives, pyrazole derivatives, tetrazole derivatives, benzimidazole derivatives, oxazole, isoxazoles, etc. The book also covers the topic of nanocarriers as drug delivery vectors. Given the contents, the book will be useful for students, researchers and professionals working in the area of biomaterials and nanomaterials.Table of ContentsChapter 1 Brief history, pathophysiology, transmission of SARS-CoV-2 virus, and recent advances on transition metal complexes and nanocomposites as the potent antiviral agents from COVID-19 perspectivesChapter 2 Nanocarriers as Drug Delivery VectorsChapter 3 Cocrystals and their induced activity of drugsChapter 4 An Introduction on Evolution of Azole Derivatives in Medicinal ChemistryChapter 5 Overview on Biological Activities of Thiazole DerivativesChapter 6 Overview on Biological Activities of Imidazole DerivativesChapter 7 Overview on Biological Activities of Pyrazole DerivativesChapter 8 An Overview on Biological Evaluation of Tetrazole DerivativesChapter 9 An Overview on Biological Activity of Benzimidazole DerivativesChapter 10 An overview on Biological Activities of Oxazole, Isoxazoles and 1,2,4-oxadiazoles DerivativesChapter 11 An Overview on Biological Activities of 1,2,3-Triazole Derivatives

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Book SynopsisThis book describes the author’s work on the development of sequence-specific DNA binders for the therapy of mitochondrial diseases. In the first chapter, the author provides a detailed background of pyrrole–imidazole polyamides (PIPs) and mitochondrial disease research followed by chapters presenting the author's own research and discoveries. Firstly, the developed compounds called MITO-PIPs, which recognize specific sequences in mitochondrial DNA, are presented. The following chapter demonstrates how, by introducing a DNA alkylating reagent into a MITO-PIP that recognizes the adjacent sequence to a target mutation, the copy number of mutated mitochondrial DNA was successfully reduced in live cells. Furthermore, because nuclear DNA is another important target for treating mitochondrial diseases, the author demonstrated that tri-arginine vectors can enhance nuclear uptake of PIPs and improve their biological activity in cells.This work will attract readers’ interest because it paves the way for a transgene-free chemical gene therapy for mitochondrial diseases. The book includes a detailed description of experimental procedures, especially compound synthesis. This description helps readers to have a clear image of the author’s studies and to perform similar and extended studies themselves.Table of ContentsGeneral Introduction.- Creation of Synthetic Ligand for Mitochondrial DNA sequence Recognition and Promoter-Specific Transcription Suppression.- Allele-Specific Replication Inhibition of Mitochondrial DNA by MITO-PIP Conjugated with Alkylation Reagent.- Enhanced Nuclear Accumulation of Pyrrole–Imidazole Polyamides by Incorporation of the Tri-arginine Vector.

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Book Synopsis This book on biopolymers offers a comprehensive source for biomaterial professionals. It covers all elementary topics related to the properties of biopolymers, the production, and processing of biopolymers, applications of biopolymers, examples of biopolymers, and the future of biopolymers. Edited by experts in the field, the book highlights international professionals’ longstanding experiences and addresses the requirements of practitioners and newcomers in this field in finding a solution to their problems. The book brings together several natural polymers, their extraction/production, and physio-chemical features. The topics covered in this book are biopolymers from renewable sources, marine prokaryotes, soy protein and humus oils, biopolymer recycling, chemical modifications, and specific properties. The book also focuses on the potential and diverse applications of biogenic and bio-derived polymers. The content includes industrial applications of natural polymeric molecules and applications in key areas such as material, biomedical, sensing, packaging, biomedicine, and biotechnology, and tissue engineering applications are discussed in detail. The objective of this book is to fill the gap between the researchers working in the laboratory to cutting-edge technological applications in related industries. This book will be a very valuable reference material for graduates and post-graduate students, academic researchers, professionals, research scholars, and scientists, and for anyone who has a flavor for doing biomaterial research. The books are designed to serve as a bridge between undergraduate textbooks in biochemistry and professional literature. The book provides universal perspectives for an emerging field where classical polymer science blends with molecular biology with highlights on recent advances. Table of ContentsBiopolymers: State of the art and new challengesBiopolymers from renewable sources Recent approaches towards Bacterial NanoCellulose (BNS) synthesis Bacterial nanocellulose from agro-industrial wastes Biopolymers from marine prokaryotes Biomolecules from humus oil Soy protein biopolymer Piezoelectric Properties of Biopolymers Optical properties of biopolymers: Theoretical and experimental advancesMechanical properties of biopolymers Thermal properties of biopolymers Gas barrier properties of biopolymers Structural, morphological and textural properties of biopolymers Tuning the hydrophilic/hydrophobic behavior of biopolymers: Surface modificationsBiopolymer based blends Biopolymer Based Interpenetrating Polymer Networks Biopolymer based gels Biopolymer based composites Biopolymer based nanocomposites Biopolymer based blend nanocomposites Nanofibres and Nanomembranes of biopolymers Biopolymer Based Soil Treatment for Geotechnical Engineering Applications Biopolymers as Engineering Materials Biopolymer based nanocomposites for the treatment of organic pollutants from the synthetic wastewater: ApplicationBio-Medical Applications of Chitin Sustainable biodegradation and extraction of keratin with its applications Material applications of gelatin Natural rubber and guttapercha rubber: ApplicationsAlbumin Engineering applicationsTunable biopolymers Biomedical applicationsNanocellulose from cladophoro ApplicationsCellulose nanocrystals(CNCs)supported inorganic nanomaterials for catalytic applications Bacterial nanocellulose (BNCs) supported inorganic nanomaterials for catalytic applications Bio-compatibility of nanocellulose: Emerging biomedical applicationsSensing and biosensing applications of nanocellulose Packaging Applications of Biodegradable Nanocellulose Composites Nanocellulose based (bio)composites for optoelectronic applications Biopolymers for edible films and coatings in food applications Peptide-based biopolymers in biomedicine and biotechnology Cross-linking biopolymers for biomedical application Natural fibre reinforced biopolymers as construction materials Polylactic acid (PLA): ApplicationsBiopolymer films and composite coatings: ApplicationsGas barrier properties and applications of nanocellulose based materials Applications of Biopolymer-Based Nanofibers and Nanomembranes Amylose-Amylopectin ratio: comprehensive understanding of structure, physico-chemical attributes and applications of starchBiopolymers: Building blocks for the synthesis of advanced materials Nature Inspired Biomimetic Polymeric Materials and Its Applications Cosmetic applications of albumin Biodegradation of Biopolymers:Reflections Towards Possible Biomagnification Definitions and AssessmentBiopolymer waste management: Reuse, Recycling and disposalSafety issues, environmental impacts and health effects of biopolymers Challenges and issues in biopolymer applications

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Book SynopsisThis book presents the advancement of coating materials technology especially in agriculture, particularly for fertilizers. Fertilizers are a critical component in meeting rising demands and ensuring global food security. A new generation of fertilizers made by coating granules with biopolymers address these issues. Coating in agriculture is an important area in research for a more sustainable future. Many examples and instances from existing research and related research gaps are discussed. It includes applications of composites as fertilizer’s coating, advantages and disadvantages of fertilizer coating from composites, applications of bacteria in composite, applications of bacteria in fertilizer industry as well as the common techniques of coating fertilizers with drying process. ​Table of ContentsChapter 1. Introduction to Bio-coating.- Chapter 2. Bio-coating from Composite Materials.- Chapter 3. Bacteria in Bio-coating.- Chapter 4. Evaluation of Bio-coating.- Chapter 5. Techniques of Bio-coating Evaluation.- Chapter 6. Conclusion.-References ​

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Book SynopsisThis book presents high-quality peer-reviewed articles from the 2nd International Conference on Biomass Utilization and Sustainable Energy 2022 (ICoBiomasSE 2022) organized by the Centre of Excellence for Biomass Utilization (COEBU), Universiti Malaysia Perlis (UniMAP), Malaysia. The theme of the conference “Emerging Technology for Future Sustainability” is chosen in view of the current revolution and rapid developments in the field of biomass innovation towards sustainable development. The contents are broadly divided into five parts: (1) sustainable biomass resources for decarbonizing the economy, (2) biomass conversion technologies for bioenergy and biofuels, (3) biomass conversion to intermediates and products, (4) bioeconomy sustainability, impacts and policies and (5) bioenergy integration. It provides a platform for students, professionals, researchers, academicians, policymakers and industries working in the areas of biomass utilization and sustainable energy to solve long-standing environmental issues for a healthier planet.​Table of ContentsPhytoremediation Potential of Salvinia molesta to Reduce Ni and Cd from Simulated Wastewater.- Soil Risk Assessment on the Usage of Molasses-Based Distillery Effluent for Paddy Irrigation: Heavy Metals Content.- Effects of Soil Conditioners on Rice Growth and Soil Properties under Water Stress at Vegetative Stage.- Soil Amelioration Effects on Morphology Traits of Upland Rice Root-Shoot and Soil Productivity under Water Deficit.- Comparison of Corn and Tapioca Starch Binders on the Characteristic of Rice Straw Charcoal Briquettes.- Pretreatment of Leucaena leucocephala Using Deep Eutectic Solvent for Ethanol Production by Kluyveromyces marxianus UniMAP 1-1.- Deep Eutectic Solvent Pretreatment of Rubber Seed Shells for Cellulose and Hemicellulose Production.- Inhibition Study on the Growth of Clostridium Saccharoperbutylacetonicum N1-4 (ATCC 13564) For the Production Biobutanol in ABE Fermentation.- Thermogravimetric Analysis on Empty Fruit Bunch, Rice Husk, and Rice Straw for Feedstock in Biomass Gasification.- A Review on Enhancement of Oil Palm Solid Waste through Torrefaction.- Energy Efficiency of Briquettes from Queen Pineapple (Ananas comosus [Linn.] Merr.) Wastes Using Three Organic Binders.- Optimization of Biobutanol Production from Detoxified Palm Kernel Cake Hydrolysate by Clostridium Acetobutylicum YM1.- Mixed Matrix Membrane (MMMs) as Membrane Based Separation Technology: A Review.- Application of Machine Learning for Biogas Production from Lignocellulosic Biomass.- Utilization of Spent Coffee Ground As Adsorbent for Nitrate Removal.- Nitrate Adsorption using Spent Coffee Ground: Kinetics, Isotherm, and Thermodynamic Studies.- Impact of Power Supply on Electro-Precipitation of Nickel Hydroxide from Industrial Electronic Waste.- Optimization of Nickel Electrowinning from Simulated Watts Bath of Electronics Industrial Waste.- Bio-based Packaging Materials for Fruit and Vegetables - Current Applications and Future Trends: A Review.- Deep Eutectic Solvent-Assisted Synthesis of Nanocrystalline Cellulose Adsorbent for Silver Nitrate Removal.- Optimization of an Ultrasound-Assisted Extraction Method for Phenolic Content in Momordica Charantia Seeds and it’s Antifungal Activity Against Pleurotus ostreatus Green Mould Pathogen.- Optimization of Rice Bran Protein Extraction Using Choline Chloride-Glycerol Deep Eutectic Solvent Using Response Surface Methodology (RSM).- Traditional Paddy Farmers Perception on Bioeconomy Social Change on Adapting Internet of Things in Precision Farming.- Bioeconomy of Local Soybean Farming to Increasing Commodity Competitiveness.- Microbial Fuel Cell: Simultaneous Bioremediation and Energy Recovery Technology.- Green Renewable Energy: Microbial Fuel Cell Technology.

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Book SynopsisThis book presents the selected papers presented at the Third International Congress of Applied Chemistry & Environment (ICACE–3) that took place on May 27-29, 2022. The topics of the conference covers topics from the thematic sections: (1) Environment and Climate Change; (2) Green Chemistry and Natural Substances; (3) Biobased Materials and Nanomaterials; (4) Sustainable Textiles and Clean Processes. For this edition of the conference, it is devoted to present the advantage to use annual plants and/or lignocellulose material as sources for production of fibers and/or cellulose derivatives and/or nanocellulose material with focus on their processing, properties and applications. This book benefits lecturers, students, researchers and industrialists who are working in the field of natural fiber especially in order to preserve the forest resource and to satisfy the increasing demand in pulps.Table of ContentsAntibacterial activity of polyamide and high-density polyethylene nets grafted with polyethylene glycol.- Ecofriendly Extraction of Natural Dye From Waste of Cucurbita Pepo Using Assisted Microwave Method.- Adsorption studies of atrazine herbicide from aqueous solutions using Typha australis as an inexpensive adsorbent: A preliminary investigation.- Use of nanofluid to improve the efficiency of photovoltaic panel.- Kinetic study of dyeing (PET/PTT) bicomponent polyester textiles using ecofriendly carriers.- Preliminary Physicochemical and Phytochemical Study of Seeds of Ziziph us mauritiana.- Effect of some parameters on the efficiency of solar distiller.- Reuse of grain waste as abrasive particles.- Tear strength properties of recycled denim fabrics under mixed washing using Smart Foam technology.- Study of Solar Heating process of Greenhouse in the Gabès Region.- Ergonomic study and work transformation in a clothing industry.

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Book SynopsisThis book gives an overview of the processing, properties, and applications of fibers and cellulose derivatives obtained from annual plant materials in the formation of non-wood source of pulp. The book comprises illustrations and tables summarizing the latest research on the production of fibers and cellulose derivatives using several key methods and/or characterization techniques. This book collates the information and knowledge of new ways to prepare cellulosic derivatives and describe the concepts and architecture of fibers obtained from annual plants. This book caters to researchers, policymakers, and industrial practitioners who are interested in natural fibers as a way to preserve the forest resource and to satisfy the increasing demand in pulps. Table of Contents1. Characterization and comparative evaluation of structural, chemical, thermal, mechanical, and morphological properties of plant fibers2. Characterization and comparative evaluation of thermal, structural, chemical, mechanical and morphological properties3. Recent developments in pretreatment strategies on annual plant residues for bioethanol production: Technological progress and challenges4. Production of cellulose nanocrystal from date palm and their comparison with others sources5. Preparation and characterization of cellulose nanofibril from annual plant6. Characterization of nanocellulose obtained from cactus7. Corn crop residues as source to obtain cellulose nanocrystals8. Recent nanocelullose applications for sustainable agriculture – A review9. Alternative adhesives for composites made of annual plants10. Annual Plant Reinforced Biocomposite Fiberboards – Investigation on Mechanical Properties11. Nanocomposites with cellulose nanocrystals extracted from annual plants12. Advances in the production of cellulose nanomaterials and their use in engineering (bio)plastics13. An overview on the pharmaceutical applications of nanocellulose14. Preparation and characterization of cellulosic derivatives from annual plant15. Structure and properties of cellulose and its derivatives16. Activated Carbon from agricultural waste for the removal of pollutants from aqueous solution17. Valorization of annual plants in removing synthetic dyes18. Schinus molle: Currently status and opportunity

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