Infectious and contagious diseases Books

Book SynopsisFully revised for its third edition, the Oxford Handbook of Expedition and Wilderness Medicine continues to be the essential resource for all expedition medics and well-informed travellers, as well as nurses, paramedics, medical students, and other expedition members travelling in remote, wilderness areas of the world. Now containing more guidance about caving medicine, the third edition includes revised and additional illustrations and essential maps of the spread of diseases. Clear and concise, readers can rely on this handbook to provide the key knowledge and practical advice they need. It enables efficient preparation and planning before the journey, advises on camp logistics, risk management, and medical problems during the expedition, as well as highlighting rare but important risks to those visiting remote areas. Focusing on preventative measures, it also contains chapters dealing with crisis management, emergency care, and evacuation from challenging environments, with guidance about the obligations of a clinician joining an expedition, ethical approaches to such work, and medicine in various extreme environments. This edition will give you the confidence and skills you need to travel to any extreme or remote environment. Incorporating the combined knowledge and experience of a team of experienced clinicians and expeditioners, this is a practical, easy-to-use guide to all aspects of expedition and wilderness medicine.Table of Contents1: Expedition medicine 2: Preparations 3: Caring for people in the field 4: Ethics and responsibilities 5: Crisis management 6: Emergencies: diagnosis 7: Emergencies: trauma 8: Emergencies: collapse and serious illness 9: Treatment: skin 10: Treatment: head and neck 11: Treatment: dental 12: Treatment: chest 13: Treatment: abdomen 14: Treatment: limbs and back 15: Treatment: infectious diseases 16: Psychological and psychiatric problems 17: Risks from animals 18: Plants and fungi 19: Anaesthesia in remote locations 20: Cold climates 21: Mountains and high altitude 22: Inland and coastal waters 23: Offshore 24: Underwater 25: Hot, dry environments: deserts 26: Hot, humid environments: tropical forest 27: Caving 28: Medical kits

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Book SynopsisThis concise, beautifully illustrated book provides a convenient introduction to the basic science of medical microbiology and how this relates to clinical practice. Expanded from the prize-winning first edition to cover virology and parasitology in addition to bacteriology, this second editions explains the essentials of microbial infection and continues to provide a sound basis for developing logical diagnostic and management strategies, including the critical area of antibiotic usage. Section One focuses on the clinical with chapters centred around infections of the organ systems, while full coverage of the scientific aspects underpinning microbial disease follows in Section Two. Table of ContentsSection One: Clinical Aspects of Microbial Infection. Introduction to Clinical Microbiology. Anti-Infective Guidelines in the Hospital. The Clinical Microbiology Laboratory. Preventing Disease and Infection Control. Infections of the Blood. Infections of the Urinary Tract. Infections of the Respiratory Tract. Tuberculosis. Infections of the Liver including Viral Hepatitis. Infections of the Nervous System. Infections of the Skin, Soft Tissues, Bones and Joints. Infections in a Modern Society. Section Two: Scientific Basis of Microbial Infection. The Structure and Function of Prokaryotic and Eukaryotic Cell. The Classification of Bacteria, Fungi and Parasites. The Structure and Replication of Viruses. How Organisms Cause Disease. The Science of Anti-infective Agents and Resistance. Appendix One: Notifiable Diseases. Appendix Two: Key Point Summary of Organisms and Conditions.

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Book SynopsisThe new edition of this unique handbook continues to provide an accessible and comprehensive, signs-and-symptoms based source of information on medical problems commonly seen in the tropics. A practical guide to diagnosis and management for medical practitioners and students, it provides vital information at the reader's fingertips.Trade ReviewThis is a highly useful handbook for clinicians in tropical disease environments. The topics are presented with tremendousclarity and economy of language. * Kenneth Schaefle, MD (Albert Einstein College of Medicine), Doody's *Review from previous edition This book presents information in a simple manner combined with updated current knowledge, making it a useful adjunct for its intended readers. * BMA Book Awards 2014. Highly Commended *This is a useful resource for healthcare providers who work in limited-resource settings and/or in tropical areas. * Doody's *Overall, this book is well written, easy to read and practical, providing easy access to crucial information, from common problems to rare diseases. * Dipti Patel , Occupational Medicine Book Review *Table of Contents1: Management of the sick child 2: Malaria 3: HIV medicine 4: Tuberculosis 5: Chest medicine 6: Gastroenterology 7: Cardiovascular 8: Renal Medicine 9: Neurology 10: Haematology 11: Endocrine disorders 12: Ophthalmology 13: Dermatology 14: Bone, joint and soft tissue infections 15: Sexually Transmitted Infections 16: Nutrition 17: Multi-system diseases and infections 18: Mental health 19: Trauma 20: Poisoning and envenoming 21: Immunization 22: Health emergencies in humanitarian crises 23: Obstetric emergencies 24: Healthcare-associated infection, antimicrobial prescribing, and antimicrobial resistance

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Book SynopsisCompletely updated and revised, and now published in its sixth edition, this best-selling text has provided an essential overview of the subject for almost 25 years. A comprehensive yet synoptic account of communicable diseases, it covers theory, epidemiology and control, then systematically groups diseases by their main means of transmission. There are special chapters on infections in pregnancy and the concern of new and emerging diseases, and an annex lists all 353 diseases in an easy reference table. This edition includes updates to all chapters and a new section on melioidosis. It: - Provides information concisely so it can be found at a glance. - Includes numerous clear diagrams, bullet points and tables for rapid review and learning. - Contains a new full-colour internal design and online lecture slides to facilitate teaching. Communicable Diseases continues to provide an essential resource for doctors, medical students and all those in public health, and for healthcare workers needing a comprehensive yet concise practical text.Table of Contents1: Elements of Communicable Diseases 2: Communicable Disease Theory 3: Control Principles and Methods 4: Control Strategy and Organization 5: Notification and Health Regulations 6: Classification of Communicable Diseases 7: Diseases of Poor Hygiene 8: Faecal–Oral Diseases 9: Food-borne Diseases 10: Diseases of Soil Contact 11: Diseases of Water Contact 12: Skin Infections 13: Respiratory Diseases and Other Airborne-transmitted Infections 14: Diseases Transmitted via Body Fluids 15: Insect-borne Diseases 16: Ectoparasite Zoonoses 17: Domestic and Synanthropic Zoonoses 18: Pregnancy and Infection 19: New and Emerging Diseases 20: List of Communicable Diseases

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Book SynopsisInstant #1 New York Times bestseller! • #1 Washington Post bestseller! • #1 Indie Bestseller! • USA Today Bestseller!John Green, acclaimed author and passionate advocate for global healthcare reform, tells a deeply human story illuminating the fight against the world’s deadliest infectious disease. Signed edition“The real magic of Green’s writing is the deeply considerate, human touch that goes into every word.” –The Associated Press″Told with the intelligence, wit, and tragedy that have become hallmarks of the author’s work.... This is the story of us.” –Slate“Earnest and empathetic.” –The New York TimesTuberculosis has been entwined with hu­manity for millennia. Once romanticized as a malady of poets, today tuberculosis is seen as a disease of poverty that walks the trails of injustice and inequity we blazed for it.In 2019, author John Green met Henry Reider, a young tuberculosis patient at Lakka Government Hospital in Sierra Leone. John be­came fast friends with Henry, a boy with spindly legs and a big, goofy smile. In the years since that first visit to Lakka, Green has become a vocal advocate for increased access to treatment and wider awareness of the healthcare inequi­ties that allow this curable, preventable infec­tious disease to also be the deadliest, killing over a million people every year.In Everything Is Tuberculosis, John tells Henry’s story, woven through with the scientific and social histories of how tuberculosis has shaped our world—and how our choices will shape the future of tuberculosis.

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Book SynopsisThe CDC Yellow Book has been a trusted resource among healthcare professionals for over half a century. It compiles the US government's current travel health guidance, providing travel medicine specialists, healthcare professionals, and travelers with expert guidance for safe and healthy international travel. Along with disease-specific prevention and treatment recommendations, this comprehensive reference text equips readers with the background and context needed to understand and address public health threats associated with all types of international travel. With chapters written by subject matter experts in the travel medicine field, this edition features the following topics: Vetted recommendations for pre-travel vaccinations and preventative care, including public health guidance for specific destinations and types of travel Profiles of the most common travel-associated infections and health conditions Special sections tailored to travelers with additional considerations, includi

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Book SynopsisGround-breaking, evidence-based book asks how many lives were lost because of Chinas negligence about lab-leaked SARS-CoV-2. In a disturbing reconstruction of events by two of the most reputable scientists in the world, a new book reveals for the first time how Chinese authorities and elite Wuhan scientists knew about SARS-CoV-2s menacing biological features from the start but remain silent to this day. In The Origin of the Virus (Clinical Press) Dr Steven Quay and Prof Angus Dalgleish, working with Italian reporter Paolo Barnard, show how China engaged in lies, omissions and obfuscations to cover up the laboratory origin of the virus. Had they immediately alerted the international community and policymakers of the extremely pathogenic molecular machinery present in SARS-CoV-2's genome, very large numbers of lives may have been spared, argue Quay, Dalgleish and Barnard. The authors provide a shocking account of the extreme experiments that led to the outbreak of the worst pandemic since the 1918 Spanish influenza. They broaden the censure to explain why some American and British scientists thwarted a proper investigation of the origin of COVID-19. Despite its impeccable scientific grounding the book is both a readable and gripping account that, for the first time, allows the public to partake in what lies at the heart of the many scandals surrounding the birth of the most deadly virus in modern times.Trade ReviewThe beauty of this book lies in its totally convincing narrative in a concise and entirely readable form. As a lay person with regard to medical matters I found the introductory chapter by the man who put the project together, Paolo Barnard, both fascinating and compelling, reading like a particularly enthralling story. Then the science kicks in with some hard academic research from Professor Dalgleish examining the genome of the virus and the peculiar nature of the spike proteins put there by Gain of Function studies of concern. Although impeccable in its reasoning the matters were explained in terms that are fully understandable. Then follows a nice cheeky chapter from doctor/scientist Steven Quay at the end of the book which lays out in a wonderfully logical manner how a bookie might view the odds of either zoonosis or lab-leak as the origin of the virus causing the Covid-19 pandemic .... an analysis supported by something called Bayesian statistics. I have read other books on the same matter but in my opinion this is the best .... the rival tomes are too large, filled out by journalese or just plain wrong. Once you realise that the virus has been made in a unique way such that it can attack almost any cell in the human body you begin to understand the importance of preventative measures and also become angry that the dangerous Gain of Function studies are continuing and worried that unless they are stopped the next pandemic of a novel virus will be even worse. Anthony Lloyd, primary schoolteacher and musician in Bristol, England (Review in Caduceus)

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Book SynopsisTrade Review"A New Statesman Essential Non-Fiction Book of 2021""Winner of the PROSE Award in the History of Science, Medicine, and Technology, Association of American Publishers""A Choice Outstanding Academic Title of the Year""[A] superb new history of infectious disease. Be so grateful you live now!"---David Frum"Magisterial. . . . [Harper’s] mastery of the science is only matched by the ease of his prose. If I were to nominate a book of the year, it would be this one."---Andrew Sullivan, The Dishcast"[A] sweeping masterpiece. . . . It’s difficult for me to think of anyone who will not find something eye-opening and enlightening in the pages of this comprehensive, beautifully written and eloquent book." * Forbes *"Plagues upon the Earth is a remarkable achievement."---Talha Burki, The Lancet"This magnificent book stood out as much for its nuance and academic rigour as it did for its readability." * Inquisitive Biologist *"An ambitious, engaging, and unified history of humanity’s interaction with infectious disease."---Gregory J. Morgan, Science"By integrating history, demography, economics, evolutionary biology and genomics into a seamless narrative, [Harper] does something that I, for one, have never seen before done so eloquently or persuasively: he demonstrates that any thorough understanding of health requires the kind of sweeping perspective that the humanities offers."---Steve Mintz, Inside Higher Ed"Comprehensive."---Tyler Cowen, Marginal Revolution"A remarkable accomplishment that weaves together microbiology, history, and economics to understand the role of diseases in shaping human history. Harper, an established historian known for his first three books on Rome and late antiquity, has an impressive command of virology, bacteriology, and parasitology as well as history and economics. In 'Plagues Upon the Earth.' he explains all of these clearly and with many arresting turns of phrase and insights."---Alex Tabarrok, Marginal Revolution"Well-conceived. … [Kyle] Harper combs through the literature of history, economics, epidemiology, and other disciplines to deliver a solid study of the role of infectious disease in the human story. ... Harper’s long-view study is a welcome addition to the spate of recent books on epidemic disease." * Kirkus Reviews *"This is a solid book, superbly referenced and interdisciplinary, covering disease from pre-human origins to the present, and making extensive use of published DNA comparisons and descriptions of plagues by historical observers." * Choice *"Completing the reading of this book leaves one with more than a feeling of satisfaction. Admiration for a major task that was written in an engaging style that retains a facile elegance throughout its 700 pages, that presents comprehensive and detailed information as though it were the sort of material that readers come across every day, is what one might not expect, but welcomes, in a serious work of this size."---Ian Lipke, Queensland Reviewers Collective"This timely work is the book of extraordinary brilliance and scope and the most significant in the field since William McNeill’s Plagues and Peoples from the mid-1970s."---David Lorimer, Paradigm Explorer"Magisterial." * Prospect *"Plagues Upon the Earth is a highly provoking and enjoyable read. It shows that our success as a species is equally paralleled to the success of pathogens"---Makayla Alderson Fox, World History Encyclopedia

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Book SynopsisCelebrated science writer Carl Zimmer’s classic book, updated in a new edition, is an eye-opening look at Covid-19 and the many other viruses that shape our planet and ourselves.Trade Review"A smart, beautiful, and somewhat demented picture book that's likely to give you a case of the willies. In the best way possible."-- "Boing Boing, on the first edition" "Absolutely top-drawer popular science writing. . . . Zimmer's information-packed, superbly readable look at virological knowledge awakens readers to the fact that not only are viruses everywhere but we couldn't live without them."-- "Booklist, starred review, on the first edition" "As with any great journey, this virtual tour opens your eyes and expands your horizons. . . . Reading Zimmer's work is like hanging out with the smartest, most interesting guy you have ever met as he regales you with tales of his travels and fascinating finds along the way."-- "Science News, on the first edition" "Just about everything you've always wanted to know--and a lot you'll probably wish you didn't know--about the viruses that have caused humanity so much grief throughout history."-- "Forbes, on the first edition" "Succinct yet elegantly written. . . . A fascinating and enlightening introduction."-- "Guardian, on the first edition" "Zimmer reshapes our understanding of the hidden realities at the core of everyday existence. . . . Concise and illuminating."-- "Washington Post, on the first edition" "Zimmer is one of the best science writers we have today. A Planet of Viruses is an important primer on the viruses living within and around all of us--sometimes funny, other times shocking, and always accessible. Whether discussing the common cold and flu, little-known viruses that attack bacteria or protect oceans, or the world's viral future as seen through our encounters with HIV or SARS, Zimmer's writing is lively, knowledgeable, and graced with poetic touches."--Rebecca Skloot, author of The Immortal Life of Henrietta Lacks "on the first edition"

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Book SynopsisOffers an introduction to the modeling of infectious diseases in humans and animals. This book moves from modeling with simple differential equations to more complex models, where spatial structure, seasonal 'forcing', or stochasticity influence the dynamics, and where computer simulation needs to be used to generate theory.Trade Review"Matt Keeling and Pejman Rohani...have made important and original contributions to epidemiology...and are well qualified to deliver an authoritative, comprehensive and up-to-date review. [The authors] advocate...the use of mathematical models to help design disease-control programs. They recognize that modeling is a partnership between modelers and empiricists. For that reason, I hope that [readership] will extend beyond existing and new devotees of this challenging and exciting discipline."--Mark Woolhouse, Nature "This book represents a valuable step toward educating readers to have greater appreciation and understanding of the development of mathematical models in infectious diseases."--Carol Y. Lin, Biometrics Book Reviews "[T]he authors have created a well written and essential reference for epidemiologists, mathematicians and other scientists interested in the mathematical modeling of infectious diseases."--Michael Hohle, Biometrical JournalTable of ContentsAcknowledgments xiii Chapter 1: Introduction 1 1.1 Types of Disease 1 1.2 Characterization of Diseases 3 1.3 Control of Infectious Diseases 5 1.4 What Are Mathematical Models? 7 1.5 What Models Can Do 8 1.6 What Models Cannot Do 10 1.7 What Is a Good Model? 10 1.8 Layout of This Book 11 1.9 What Else Should You Know? 13 Chapter 2: Introduction to Simple Epidemic Models 15 2.1 Formulating the Deterministic SIR Model 16 2.1.1 The SIR Model Without Demography 19 2.1.1.1 The Threshold Phenomenon 19 2.1.1.2 Epidemic Burnout 21 2.1.1.3 Worked Example: Influenza in a Boarding School 26 2.1.2 The SIR Model With Demography 26 2.1.2.1 The Equilibrium State 28 2.1.2.2 Stability Properties 29 2.1.2.3 Oscillatory Dynamics 30 2.1.2.4 Mean Age at Infection 31 2.2 Infection-Induced Mortality and SI Models 34 2.2.1 Mortality Throughout Infection 34 2.2.1.1 Density-Dependent Transmission 35 2.2.1.2 Frequency Dependent Transmission 36 2.2.2 Mortality Late in Infection 37 2.2.3 Fatal Infections 38 2.3 Without Immunity: The SIS Model 39 2.4 Waning Immunity: The SIRS Model 40 2.5 Adding a Latent Period: The SEIR Model 41 2.6 Infections with a Carrier State 44 2.7 Discrete-Time Models 46 2.8 Parameterization 48 2.8.1 Estimating R0 from Reported Cases 50 2.8.2 Estimating R0 from Seroprevalence Data 51 2.8.3 Estimating Parameters in General 52 2.9 Summary 52 Chapter 3: Host Heterogeneities 54 3.1 Risk-Structure: Sexually Transmitted Infections 55 3.1.1 Modeling Risk Structure 57 3.1.1.1 High-Risk and Low-Risk Groups 57 3.1.1.2 Initial Dynamics 59 3.1.1.3 Equilibrium Prevalence 62 3.1.1.4 Targeted Control 63 3.1.1.5 Generalizing the Model 64 3.1.1.6 Parameterization 64 3.1.2 Two Applications of Risk Structure 69 3.1.2.1 Early Dynamics of HIV 71 3.1.2.2 Chlamydia Infections in Koalas 74 3.1.3 Other Types of Risk Structure 76 3.2 Age-Structure: Childhood Infections 77 3.2.1 Basic Methodology 78 3.2.1.1 Initial Dynamics 80 3.2.1.2 Equilibrium Prevalence 80 3.2.1.3 Control by Vaccination 81 3.2.1.3 Parameterization 82 3.2.2 Applications of Age Structure 84 3.2.2.1 Dynamics of Measles 84 3.2.2.2 Spread and Control of BSE 89 3.3 Dependence on Time Since Infection 93 3.3.1 SEIR and Multi-Compartment Models 94 3.3.2 Models with Memory 98 3.3.3 Application: SARS 100 3.4 Future Directions 102 3.5 Summary 103 Chapter 4: Multi-Pathogen/Multi-Host Models 105 4.1 Multiple Pathogens 106 4.1.1 Complete Cross-Immunity 107 4.1.1.1 Evolutionary Implications 109 4.1.2 No Cross-Immunity 112 4.1.2.1 Application: The Interaction of Measles and Whooping Cough 112 4.1.2.2 Application: Multiple Malaria Strains 115 4.1.3 Enhanced Susceptibility 116 4.1.4 Partial Cross-Immunity 118 4.1.4.1 Evolutionary Implications 120 4.1.4.2 Oscillations Driven by Cross-Immunity 122 4.1.5 A General Framework 125 4.2 Multiple Hosts 128 4.2.1 Shared Hosts 130 4.2.1.1 Application: Transmission of Foot-and-Mouth Disease 131 4.2.1.2 Application: Parapoxvirus and the Decline of the Red Squirrel 133 4.2.2 Vectored Transmission 135 4.2.2.1 Mosquito Vectors 136 4.2.2.2 Sessile Vectors 141 4.2.3 Zoonoses 143 4.2.3.1 Directly Transmitted Zoonoses 144 4.2.3.2 Vector-Borne Zoonoses: West Nile Virus 148 4.3 Future Directions 151 4.4 Summary 153 Chapter 5: Temporally Forced Models 155 5.1 Historical Background 155 5.1.1 Seasonality in Other Systems 158 5.2 Modeling Forcing in Childhood Infectious Diseases: Measles 159 5.2.1 Dynamical Consequences of Seasonality: Harmonic and Subharmonic Resonance 160 5.2.2 Mechanisms of Multi-Annual Cycles 163 5.2.3 Bifurcation Diagrams 164 5.2.4 Multiple Attractors and Their Basins 167 5.2.5 Which Forcing Function? 171 5.2.6 Dynamical Trasitions in Seasonally Forced Systems 178 5.3 Seasonality in Other Diseases 181 5.3.1 Other Childhood Infections 181 5.3.2 Seasonality in Wildlife Populations 183 5.3.2.1 Seasonal Births 183 5.3.2.2 Application: Rabbit Hemorrhagic Disease 185 5.4 Summary 187 Chapter 6: Stochastic Dynamics 190 6.1 Observational Noise 193 6.2 Process Noise 193 6.2.1 Constant Noise 195 6.2.2 Scaled Noise 197 6.2.3 Random Parameters 198 6.2.4 Summary 199 6.2.4.1 Contrasting Types of Noise 199 6.2.4.2 Advantages and Disadvantages 200 6.3 Event-Driven Approaches 200 6.3.1 Basic Methodology 201 6.3.1.1 The SIS Model 202 6.3.2 The General Approach 203 6.3.2.1 Simulation Time 203 6.3.3 Stochastic Extinctions and The Critical Community Size 205 6.3.3.1 The Importance of Imports 209 6.3.3.2 Measures of Persistence 212 6.3.3.3 Vaccination in a Stochastic Environment 213 6.3.4 Application: Porcine Reproductive and Respiratory Syndrome 214 6.3.5 Individual-Based Models 217 6.4 Parameterization of Stochastic Models 219 6.5 Interaction of Noise with Heterogeneities 219 6.5.1 Temporal Forcing 219 6.5.2 Risk Structure 220 6.5.3 Spatial Structure 221 6.6 Analytical Methods 222 6.6.1 Fokker-Plank Equations 222 6.6.2 Master Equations 223 6.6.3 Moment Equations 227 6.7 Future Directions 230 6.8 Summary 230 Chapter 7: Spatial Models 232 7.1 Concepts 233 7.1.1 Heterogeneity 233 7.1.2 Interaction 235 7.1.3 Isolation 236 7.1.4 Localized Extinction 236 7.1.5 Scale 236 7.2 Metapopulations 237 7.2.1 Types of Interaction 240 7.2.1.1 Plants 240 7.2.1.2 Animals 241 7.2.1.3 Humans 242 7.2.1.4 Commuter Approximations 243 7.2.2 Coupling and Synchrony 245 7.2.3 Extinction and Rescue Effects 246 7.2.4 Levins-Type Metapopulations 250 7.2.5 Application to the Spread of Wildlife Infections 251 7.2.5.1 Phocine Distemper Virus 252 7.2.5.2 Rabies in Raccoons 252 7.3 Lattice-Based Models 255 7.3.1 Coupled Lattice Models 255 7.3.2 Cellular Automata 257 7.3.2.1 The Contact Process 258 7.3.2.2 The Forest-Fire Model 259 7.3.2.3 Application: Power laws in Childhood Epidemic Data 260 7.4 Continuous-Space Continuous-Population Models 262 7.4.1 Reaction-Diffusion Equations 262 7.4.2 Integro-Differential Equations 265 7.5 Individual-Based Models 268 7.5.1 Application: Spatial Spread of Citrus Tristeza Virus 269 7.5.2 Applilcation: Spread of Foot-and-mouth Disease in the United Kingdom 274 7.6 Networks 276 7.6.1 Network Types 277 7.6.1.1 Random Networks 277 7.6.1.2 Lattices 277 7.6.1.3 Small World Networks 279 7.6.1.4 Spatial Networks 279 7.6.1.5 Scale-Free Networks 279 7.6.2 Simulation of Epidemics on Networks 280 7.7 Which Model to Use? 282 7.8 Approximations 283 7.8.1 Pair-Wise Models for Networks 283 7.8.2 Pair-Wise Models for Spatial Processes 286 7.9 Future Directions 287 7.10 Summary 288 Chapter 8: Controlling Infectious Diseases 291 8.1 Vaccination 292 8.1.1 Pediatric Vaccination 292 8.1.2 Wildlife Vaccination 296 8.1.3 Random Mass Vaccination 297 8.1.4 Imperfect Vaccines and Boosting 298 8.1.5 Pulse Vaccination 301 8.1.6 Age-Structured Vaccination 303 8.1.6.1 Application: Rubella Vaccination 304 8.1.7 Targeted Vaccination 306 8.2 Contact Tracing and Isolation 308 8.2.1 Simple Isolation 309 8.2.2 Contact Tracing to Find Infection 312 8.3 Case Study: Smallpox, Contact Tracing, and Isolation 313 8.4 Case Study: Foot-and-Mouth Disease, Spatial Spread, and Local Control 321 8.5 Case Study: Swine Fever Virus, Seasonal Dynamics, and Pulsed Control 327 8.5.1 Equilibrium Properties 329 8.5.2 Dynamical Properties 331 8.6 Future Directions 333 8.7 Summary 334 References 337 Index 361 Parameter Glossary 367

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Book SynopsisInfection: Microbiology and Management provides a core resource for the understanding of medical microbiology and infectious diseases. Content covers microbiological and clinical diagnosis, through to clinical management, epidemiology and the control of infectious conditions as they occur both in the hospital and community setting. With a concise, systems-based approach, the third edition has been revised and restructured and now covers wider epidemiological and public concerns. Key feature boxes, self assessment and case studies assist learning in each chapter. Designed to be used either as a basic learning text, or as a practical textbook in the clinical setting, Infection: Microbiology and Management, previously titled Infectious Disease, will continue to appeal to students at all stages of their career, candidates for higher examinations, the general physician and surgeon, epidemiologists and experts in public health.Trade Review"This book explains the nature, diagnosis and management of infection in a more comprehensive manner than standard clinical textbooks. It makes good links between pathology and clinical features...if you are thinking about buying a microbiology textbook, this is one of the better ones. It doesn't skimp on detail but still keeps your attention. Considering the amount of microbiology in exams, I would recommend a thorough one, like this." Northwing, Sheffield Medical Student's MagazineTable of ContentsPart 1: Infection, Pathogens and Antimicrobial Agents. 1 The Nature and Pathogenesis of Infection. 2 Structure and Classification of Pathogens. 3 Laboratory Techniques in the Diagnosis of Infection. 4 Antimicrobial Chemotherapy. Part 2: Systematic Infectious Diseases. 5 Infections with Skin, Mucosal and Soft-tissue Disorders. 6 Upper Respiratory Tract Infections. 7 Lower Respiratory Tract Infections. 8 Gastrointestinal Infections and Food Poisoning. 9 Infections of the Liver. 10 Infections of the Urinary Tract. 11 Childhood Infections. 12 Infections of the Cardiovascular System. 13 Infections of the Central Nervous System. 14 Bone and Joint Infections. Part 3: Genital, Sexually Transmitted and Birth-Related Infections. 15 Genital and Sexually Transmitted Diseases. 16 HIV Infection and Retroviral Diseases. 17 Congenital and Perinatal Infections. Part 4: Disorders Affecting More than One System. 18 Tuberculosis and Other Mycobacterial Diseases. 19 Bacteraemia and Sepsis. 20 Pyrexia of Unknown Origin. 21 Post-infectious Disorders. Part 5: Special Hosts, Environments and the Community. 22 Infections in Immunocompromised Patients. 23 Hospital Infections. 24 Travel-associated and Exotic Infections. 25 Control of Infection in the Community. 26 Emerging and Re-emerging Infections. Index

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Book SynopsisTrade Review"This book covers the history, immunology, innovative technology, and public health impacts of vaccines, and includes chapters dedicated to each of the commonly used vaccines. Moreover, the title includes a companion ebook that contains late-breaking information on topics such as Mpox, not contained within the print version. This eighth edition is an update to the previous version, published in 2017, which was prior to the widespread use of mRNA vaccines and the SARS-CoV-2 pandemic." ©Doody's Review Service, 2023, Bradford Becken, MD (University of Nebraska Medical Center) Doody's Score: 5 Stars!Table of ContentsSECTION I General Aspects of Vaccination 1 A Short History of Vaccination 2 Vaccine Immunology 3 Non-specific Effects of Vaccines 4 Correlates of Protection 5 The Vaccine Industry 6 Vaccine Manufacturing 7 Evolution of Adjuvants Across the Centuries 8 Vaccine Additives and Manufacturing Residuals in Vaccines Licensed in the United States 9 Passive Immunization SECTION II Licenced Vaccines and Vaccines in Development 10 General Immunization Practices 11 Human Adenovirus Vaccines 12 Anthrax Vaccines 13 Biodefense Vaccines, Vaccines for Emerging Infectious Diseases, and Coalition for Epidemic Preparedness Innovations (CEPI) 14 Cancer Vaccines 15 Cholera Vaccines 16 Combination Vaccines 17 Coronavirus Vaccines 18 Cytomegalovirus Vaccines 19 Dengue Vaccines 20 Vaccines Against Diarrhea Caused by Noncholera Bacteria 21 Diphtheria Toxoid 22 Ebola Vaccines 23 Nonpolio Enteroviruses 24 Epstein-Barr Virus Vaccines 25 Haemophilus Influenzae Type b Vaccines 26 Hepatitis A Vaccines 27 Hepatitis B Vaccines 28 Hepatitis C Vaccines 29 Hepatitis E Vaccines 30 Herpes Simplex Virus Vaccines 31 Human Immunodeficiency Virus Vaccines 32 Human Papillomavirus Vaccines 33 Inactivated and Recombinant Influenza Vaccines 34 Influenza Vaccine-Live 35 Japanese Encephalitis Vaccines 36 Lyme Disease Vaccines-the Journey Continues 37 Malaria Vaccines 38 Measles Vaccines 39 Meningococcal Capsular Group A, C, W, and Y Conjugate Vaccines 40 Meningococcal Vaccines Directed at Capsular Group B 41 Mumps Vaccines 42 Noninfectious Disease Vaccines 43 Norovirus 44 Parasitic Disease Vaccines 45 Pertussis Vaccines 46 Plague Vaccines 47 Pneumococcal Conjugate Vaccine and Pneumococcal Common Protein Vaccines 48 Pneumococcal Polysaccharide Vaccines 49 Poliovirus Vaccine-Inactivated 50 Poliovirus Vaccine-Live 51 Lyssaviruses and Rabies Vaccines 52 Respiratory Syncytial Virus Vaccines and Monoclonal Antibodies 53 Rotavirus Vaccines 54 Rubella Vaccines 55 Smallpox and Vaccinia 56 Staphylococcus aureus Vaccines 57 Streptococcus Group A Vaccines 58 Streptococcus Group B Vaccines 59 Tetanus Toxoid 60 Tickborne Encephalitis Vaccines 61 Tuberculosis Vaccines 62 Typhoid Fever Vaccines 63 Varicella Vaccines 64 Yellow Fever Vaccine 65 Zika Virus Vaccines 66 Zoster Vaccines SECTION III New Technologies 67 Technologies for Making New Vaccines 68 Genetic-Based Vaccine Vectors 69 Technologies to Improve Immunization SECTION IV Vaccination of Special Groups 70 Vaccination of Immunocompromised Hosts 71 Vaccines for International Travel 72 Vaccines for Healthcare Personnel 73 Vaccination of Pregnant Women SECTION V Public Health and Regulatory Issues 74 Immunization in the United States 75 Immunization in Europe 76 Immunization and Vaccine-Preventable Diseases in the Asia-Pacific Region 77 Immunization in Low- and Middle-Income Countries 78 Community Protection 79 Economic Analyses of Vaccine Policies 80 Regulation and Testing of Vaccines in the US 81 Regulation of Vaccines in Europe 82 Regulation of Vaccines in Low- and Middle-Income Countries 83 Vaccine Safety 84 Vaccine Hesitancy and Behavioral Factors Associated With Vaccine Uptake 85 Legal Issues 86 Ethics ONLINE ONLY 87 Vaccines to Prevent Mpox APPENDIX Websites and Applications for Mobile Devices With Information About Immunization Index

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Book SynopsisThis book details out the esoteric history of biological warfare in a way that no other book has done, based on only official records, documents, science and medical journals, former intelligence officers, and more. The history of this war goes much deeper than any other book on the subject has presented, based on understandings and studies of science that have been purposefully buried and obscured. The author collected and studied the work of one of history’s most exceptional yet infamous pioneers in virology and immunology, a German scientist by the name of Dr. Erich Traub, for several years, in the process of writing this book, a process which perhaps no one else has managed to undertake, until now.

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Book Synopsis Until now, review and preparation for the pediatric infectious diseases board exam could be costly, time-consuming, and generic in its approach. Moffet’s Board Review for Pediatric Infectious Diseases offers pediatric residents, fellows, and practitioners a new, effective method of study that’s both affordable and self-paced. This first-of-its-kind review tool prepares you for the board exam and for the challenges you’ll encounter in taking care of children with infections. Each chapter begins with a short overview, followed by 15-20 case-based questions, detailed explanations of correct and incorrect answers, and carefully chosen suggested readings. Answers and explanations are given in an easy-to-read bulleted format. Complete coverage of organ systems and syndromes, as well as the principles of immunization and the use of antimicrobial agents. Written by an author of Moffet’s Pediatric Infectious Diseases

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Book SynopsisSelected as a Doody's Core Title for 2022 and 2023! Defining the field of immunology for 40 years, Paul’s Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It’s an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role. Reflects the latest advances in the field, including current insights on immune system function, both basic and translational. Contains 50 chapters written by leaders in all subfields of immunology. Provides extensive coverage of the molecular biology that explains the dynamics underlying immune disorders and their treatment. Includes 10 entirely new chapters covering invertebrate and plant immunity, eosinophils, innate lymphoid cells, gamma/delta T cells, NKT and MAIT cells, immunometabolism, maternal-fetal immunology and more. Contains abundant full-color illustrations and tables that provide essential information at a glance. Features annual updates from the authors to the VST version, keeping you current with changes in this dynamic field from the experts. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. Table of ContentsContents Contributors viiForeword xiiiPreface xvii Section I. Introduction to Immunology1 Overview of the Immune System — 1Martin F. Flajnik, Steven M. Holland, Nevil J. Singh2 History of Immunology — 29Edward J. Moticka Section II. Evolution of the Immune System3 The Insect Immune System — 52Sara Cherry, Nicolas Buchon4 Evolution of the Vertebrate and Lower Deuterostome Immune System — 79Martin F. Flajnik5 The Plant Immune System — 134Roger W. Innes Section III. Cellular Pathways and Processes in Immunity6 Immunometabolism — 161Jonathan D. Powell, Chirag H. Patel, Im- Hong Sun7 Regulated Cell Death in the Immune System — 204Douglas R. Green, Sebastian Ruehl8 Lymphoid Tissues and Organs — 228Martin F. Flajnik, Nancy H. Ruddle9 Type I Cytokines, Interferons, and Their Receptors — 258Achsah D. Keegan, Warren J. Leonard10 Tumor Necrosis Factor Superfamily of Cytokines and Receptors — 308Carl F. Ware, Nancy H. Ruddle11 Chemokines and Chemokine Receptors — 344Philip M. Murphy Section IV. Innate Immunity12 Pattern Recognition Receptors and the IL- 1 Family — 386Rajendra Karki, Thirumala- Devi Kanneganti13 The Complement System — 416Erin E. West, Claudia Kemper14 Neutrophils — 455Andres Hidalgo, Mariana J. Kaplan15 Macrophages — 469Gwendalyn J. Randolph16 Mast Cells and Basophils — 487Mindy Tsai, Stephen J. Galli17 Eosinophils — 519Elizabeth A. Jacobsen, Hirohito Kita18 The Biology of Natural Killer Cells and Innate Lymphoid Cells — 537Vincent Peng, Marco Colonna Section V. Adaptive Immunity19 The Major Histocompatibility Complex — 573David H. Margulies, Kannan Natarajan, Jamie Rossjohn, James McCluskey20 Classical Antigen Processing and Presentation — 622Jonathan W. Yewdell, Paul Roche, Laurence C. Eisenlohr21 Immunoglobulins: Structure and Function — 644Mohamed Khass, David Wald, Neil S. Greenspan, Harry W. Schroeder, Jr22 Immunoglobulins: Molecular Genetics — 671Sebastian D. Fugmann23 T Cell Antigen Receptors and Antigen Recognition — 702Mark M. Davis, Yueh- Hsiu Chien24 Antigen Receptor Signaling — 734Nevil J. Singh, Gideon Wolf 25 B Cell Development in Mice — 774Nicole Baumgarth26 B Cell Responses — 798Claude- Agnès Reynaud, Jean- Claude Weill27 T Cell Development in the Thymus — 823Avinash Bhandoola, Remy Bosselut, Yousuke Takahama28 CD4+ Helper T Cells: Differentiation, Flexibility, and Heterogeneity — 856John J. O’Shea, Marion Pepper, Marc K. Jenkins, Danielle A. Chisolm29 Regulatory T Cells — 874Ethan M. Shevach30 CD8+ T Cell Memory — 924Francis R. Carbone, Thomas Gebhardt31 Cytotoxic Effector Functions — 944Morgan Huse Section VI. Integrative Immunology32 Immunologic Tolerance — 971Colin C. Anderson, Troy A. Baldwin, Peter A. Bretscher33 Fc Receptors and Their Role in Immune Regulation and Inflammation — 1008Jeffrey V. Ravetch, Aaron Gupta, Falk Nimmerjahn34 Dendritic cells — 1034Roxane Tussiwand, Pierre Guermonprez, Simon Yona35 Gamma Delta T Cells — 1054Adrian C. Hayday36 CD1- Restricted T Cells — 1102Pankaj Sharma, Florian Winau37 Mucosal- Associated Invariant T Cells and Other MR1- Reactive T Cells — 1137Sidonia B. G. Eckle, Wael Awad, Jamie Rossjohn, James McCluskey, Alexandra J. Corbett38 The Mucosal Immune System — 1178Yasmine Belkaid, Brian L. Kelsall, Warren Strober39 Introduction to Neuroimmunology — 1212Andrea Francesca Salvador, Jonathan Kipnis40 Vaccines — 1231Bali Pulendran41 Maternal- Fetal Immunology — 1283Gabrielle Rizzuto, Adrian Erlebacher Section VII. Immune Responses to Pathogens42 Response to Parasites — 1325David Sacks, Marion Pepper, Mary F. Fontana, P’ng Loke43 Immune Responses to Bacteria — 1355S. Celeste Morley, Moon H. Nahm44 Response to Viruses — 1399Hildegund C. J. Ertl45 Immunology of HIV Infection — 1445Gaurav D. Gaiha, Douglas S. Kwon Section VIII. Immunological Disease States and Immunodeficiency46 Autoimmunity and Autoimmune Diseases — 1465Gustaf Christoffersson, Ken T. Coppieters, Matthias von Herrath, Dirk Homann47 Immunologic Mechanisms of Allergic Disorders — 1515Stéphanie Lejeune, Kari C. Nadeau, David W. Scott, Joshua D. Milner48 Transplantation Immunology — 1549Megan Sykes, Anita S. Chong, Markus Y. Mapara49 Cancer Immunology and Immunotherapy — 1589Thomas F. Gajewski, Justin Kline50 Inborn Errors of Immunity — 1619Isabelle Meyts, Jean- Laurent Casanova, Luigi D. Notarangelo Index 1649

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Book SynopsisWilliam H. Foege, one of the most respected leaders in global public health, takes readers on a tour of his time at the CDC. In its seventy years, the Centers for Disease Control and Prevention (CDC) has evolved from a malaria control program to an institution dedicated to improving health for all people across the world. The Fears of the Rich, The Needs of the Poor is a revealing account of the CDC's development by its former director, public health luminary William H. Foege. Dr. Foege tells the stories of pivotal moments in public health, including the eradication of smallpox (made possible due in part to Foege's research) and the discovery of Legionnaires' disease, Reye syndrome, toxic shock syndrome, and HIV/AIDS. With good humor and optimism, he recounts the various crises he surmounted, from threats of terrorist attacks to contentious congressional hearings and funding cuts. Highlighting the people who made possible some of public health's biggest successes, Foege outlines thTrade ReviewI would recommend the book to anyone interested in, or who works within, the field of public health. It is an excellent book that can be included on reading lists for public/global health modules.—Andrew Southgate, Canterbury Christ Church University, Nursing TimesThis insider's history of the politics, health processes, and management issues involved in maintaining and expanding the CDC's influence around the world should be required reading for anyone interested in public health on a global scale.—Donovan's Literary ServicesBy sharing real stories of infectious diseases that devastated populations and how Foege and his colleagues grew into the leaders that helped bring these epidemics under control, the book provides guidance and inspiration for current and future public health workforces. Although public health can be a thankless profession, through this memoir Foege reminds us how indispensable the field is for our world's future.—Emerging Infectious DiseasesBeautiful, wonderful, clear encouraging book—Anna Maria PolidoriTable of ContentsPreface1. A Threat2. Security3. Lassa and Ebola4. A Short History of the CDC5. The Fears of the Rich and the Needs of the Poor6. Balancing Babies and the Marketplace7. Toxic Shock8. Serendipity and Unexpected Paths9. The Mysterious Deaths of Veterans10. An Unexpected Return to the CDC11. Disaster Relief12. Smallpox Claims Its Last Victims13. Coming into the United States14. Organizing for Success15. Vaccines16. Do No Harm17. Global Health18. Positive Politics19. Toxic Politics20. Reye Syndrome21. Comic Relief22. Reducing the Toll of Injuries23. Uncommon People24. AIDS25. Blind Spots26. On Budgets and BurglarsAcknowledgmentsAppendixReferencesIndex

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Book SynopsisStaying true to the unique, problem-oriented approach of Dr. Hugh Moffet’s previous editions, the fifth edition of Moffet’s Pediatric Infectious Diseases walks the reader step by step through diagnosis and management using a signs and symptoms approach. This patient-oriented structure leads to a logical development of a differential diagnosis and evaluation and treatment plan, offering clear steps to confirm the diagnosis and provide appropriate therapy.Key Features: A patient-focused, problem-oriented approach helps you develop the thought process that leads to more accurate diagnoses and better patient care – no matter how complex the patient presentation. Greatly revised content throughout, including new medications, new names of known pathogens, new practice guidelines, and extensive revisions to chapters on urinary syndromes, hepatitis syndromes, and HIV infection and AIDS. Newly streamlined format features the most notablTrade Review"valuable reference for pediatric infectious disease physicians, general pediatricians, pediatric trainees, family physicians, and other clinicians caring for children .""carefully structured to help readers refine strategies for developing relevant differential diagnoses and treatment plans .""The authors are nationally recognized leaders in the fields of pediatrics and pediatric infectious diseases.""accessible book in a clinically relevant format on the basics of pediatric infectious diseases." "designed to help readers develop a thoughtful, problem-oriented approach to diagnosis and evaluation ."Doody's Star Rating ®: 3 stars Score: 86-Doodys Publishers' Club, Friday, June 9, 2017

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Book SynopsisIntroducing the first self-help workbook on moral injury, featuring a powerful approach grounded inacceptance and commitment therapy (ACT) to help you heal moral pain and connect with a deeper sense ofmeaning and purpose.If you've experienced, witnessed, or failed to prevent an act that violates your own deeply held values-such as accidentally harming someone in an automobile accident, or failing to save someone from a dangerous situation-you may suffer from moral injury, an enduring psychological and spiritual pain that is often accompanied by post-traumatic stress disorder (PTSD), depression, substance abuse, and other mental health conditions. In order to begin healing, you need to reconnect with your values and what really matters to you as a human being. Written by a renowned team of PTSD and trauma professionals, this workbook can help. The Mindfulness and Acceptance Workbook for Moral Injury is the first workbook of its kind to offer a powerful step-by-step program to help you move beyond moral pain. With this guide, you'll learn to work through difficult thoughts, emotions, and spiritual troubles; reconnect with your deeply held sense of self, values, or spiritual beliefs; and gain the psychological flexibility you need to begin healing and live a full and meaningful life. Links to downloadable worksheets for veterans and clinicians are also included.

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Book SynopsisProvides trustworthy guidance on pediatric infectious disease prevention, management, and control. The 33rd edition continues this tradition of excellence with the latest clinical guidance on the manifestations, etiology, epidemiology, diagnosis and treatment of more than 200 childhood infectious diseases.

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Book SynopsisNicole Charles frames the refusal of Afro-Barbadians to immunize their daughters with the HPV vaccine as suspicion, showing that this suspicion is based in concrete histories of government mistrust and coercive medical practices on colonized peoples.Trade Review“Suspicion is a compellingly written and superlatively theorized ethnography of public health, affect, and the persistence of racism in the Caribbean. Nicole Charles uses suspicion to understand the logic behind Black parents' decisions about whether to give their children vaccines, showing that their decisions are rooted not in ignorance and irrationality but within long histories of racial and sexual injury as well as hierarchies related to race, class, color, education, and authority. This is quite simply a remarkable book.” -- Deborah A. Thomas, author of * Political Life in the Wake of the Plantation: Sovereignty, Witnessing, Repair *“In this empirically rich account of HPV vaccine promotion and refusal in Barbados, Nicole Charles depathologizes and unsettles conventional understandings of vaccine hesitancy through the urgent conceptual framework of suspicion. Deeply informed by and contributing to plural interdisciplinary conversations in Black feminisms, transnational gender studies, science and technology studies, and the history and anthropology of the Caribbean, Charles listens closely to insightful interlocutors in Barbados to illuminate the embodied affective intensity of contemporary vaccine politics.” -- Anne Pollock, author of * Synthesizing Hope: Matter, Knowledge, and Place in South African Drug Discovery *"Charles provides us with a thoroughly researched examination of an important subject at a time when such research is urgently needed in the face of a deadly pandemic. She shows us that parents in Barbados are motivated by genuine fears regarding the health of their children, and reasonable suspicion about the motivations of the state, and of vaccine manufacturers. That is significant for understanding how black Caribbean people evaluate technologies that affect health." -- F.S.J. Ledgister * Caribbean Quarterly *"This interesting, theoretically engaging book explores vaccine hesitancy among adolescents and young women in the English-speaking Caribbean nation of Barbados. Feminist scholars, medical anthropologists, and health-care professionals in the Caribbean and other postcolonial settings will benefit greatly from exposure to the ideas outlined in this book. Highly recommended. Lower- and upper-division undergraduates. Graduate students, faculty, and professionals. General readers." -- F. H. Smith * Choice *“Suspicion is a richly documented and theoretically ambitious ethnography of HPV vaccination hesitancy in Barbados. . . . Charles persuasively shows that Barbadians’ suspicion toward the HPV vaccination should be taken seriously, as it constitutes a productive tool for social and cultural analysis. . . . [Suspicion] is a theoretically sophisticated book that charts new territory within the literature.” -- Cristina A. Pop * Gender & Society *“This remarkable book . . . makes an important contribution to international scholarship on vaccine hesitancy, linking personal and familial decision-making in Barbados with transnational economic trends, national health and economic policies, and local embodied experiences of postcoloniality. . . . Suspicion offers a necessary correction to current received wisdom about some people’s deeply felt discomfort about vaccines, which inevitably links vaccine hesitancy with irrationality and misinformation.” -- Bernice L. Hausman * Journal of Medical Humanities *“Although numerous studies have been undertaken on vaccine confidence and its social regulators, there has rarely been a work published in this area that provides such depth of feeling to the voiced concerns of a specific community. . . . The result is a beautifully rich understanding of the complexity of human decision-making and a recognition that, at least in the case of Afro-Barbadians, ‘suspicion’ is a far more apt description of collective vaccine response than ‘hesitancy.’” -- Paula Larsson * H-Sci-Med-Tech, H-Net Reviews *Table of ContentsAcknowledgments ix Suspicion: An Introduction 1 1. Circles of Suspicion 24 2. Risk and Suspicion: An Archive of Surveillance and Racialized Biopolitics in Barbados 45 3. (Hyper)Sexuality, Respectability, and the Language of Suspicion 66 4. Care, Embodiment, and Sensed Protection 94 5. Suspicion and Certainty 115 Conclusion: Toward Radical Care 148 Notes 155 Bibliography 175 Index 191

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Book Synopsis'Manaugh and Twilley shed illuminating light on a phenomenon that seems utterly of the present moment.' Financial Times’ Best Books of the Year'Startlingly timely, authoritatively researched, and electrifyingly written.' Steve Silberman, author of NeuroTribes: The Legacy of Autism and the Future of NeurodiversityQuarantine has shaped our world, yet it remains both feared and misunderstood. It is our most powerful response to uncertainty, but it operates through an assumption of guilt: in quarantine, we are considered infectious until proven safe. An unusually poetic metaphor for moral and mythic ills, quarantine means waiting to see if something hidden inside of us will be revealed. Until Proven Safe tracks the history and future of quarantine around the globe, chasing the story of emergency isolation through time and space – from the crumbling lazarettos of the Mediterranean to the hallways of the CDC, to the corporate giants hoping to disrupt the widespread quarantine imposed by Covid-19 before the next pandemic hits through surveillance and algorithmic prediction.Yet quarantine is more than just a medical tool: Geoff Manaugh and Nicola Twilley drop deep into the Earth to tour a nuclear-waste isolation facility beneath the New Mexican desert, strip down to nothing but protective Tyvek suits to see plants stricken with a disease that threatens the world’s wheat supply, and meet NASA’s Planetary Protection Officer tasked with saving the Earth from extraterrestrial infections. The result is part travelogue, part intellectual history – a book as compelling as it is definitive, and one that could not be more urgent or timely.Trade ReviewReads like a global safari of humanity’s best-laid plans being never quite enough . . . [Manaugh and Twilley] are well-placed to tell the tale, weaving the spatial, social and scientific facets of medical isolation into an entertaining adventure. -- Oliver Wainwright * Guardian *A timely intellectual history of quarantine . . . As Manaugh and Twilley write, quarantine is enforced in cases of potential infection, of possible risk, and ­therefore admits a degree of uncertainty. One of the striking continuities in their history is how this uncertainty has been exploited to deepen gendered and racialised inequalities. -- Erin Maglaque * New Statesman *A compelling case that we must continue to refine the use of quarantine, balancing the needs of public health with those of human rights. * New Yorker *Until Proven Safe is not all doom and gloom, though: there are plenty of QI-style facts in this wide-ranging and colourful survey. -- Christopher Hart * Sunday Times *Until Proven Safe, by Geoff Manaugh and Nicola Twilley, dives into the crudely effective and widely abused strategy of quarantine, the separation of those feared to be sick from those deemed healthy. -- Ian Sample * Guardian Best Science Books of the Year *Brainy but accessible -- Mark Honigsbaum * Observer *Manaugh and Twilley shed illuminating light on a phenomenon that seems utterly of the present moment. * Financial Times' Best Books of the Year *[Manaugh and Twilley] bring an impressively wide range of interests to bear on a subject that involves not only infectious disease but also - in their ambitious yet seamless narration - politics, agriculture, surveillance and even outer space. -- Jennifer Szalai * New York Times Book Review *What makes [Until Proven Safe] compelling, besides [Manaugh and Twilley’s] extensive experience as journalists, is the depth of their research coupled with a firm conviction that quarantine, a mighty yet dangerous weapon, must be used ‘more wisely in the future’ . . . This is an exceptionally powerful book -- A. Roger Ekirch * Wall Street Journal *Until Proven Safe is uncanny in its prescience . . . Twilley and Manaugh see things that others don’t. Their insatiable curiosity reveals itself through all of their endeavors -- Allison Arieff * San Francisco Chronicle *Manaugh’s and Twilley’s extensive history of a concept we might otherwise take for granted is actually the perfect postpandemic read - an imaginative, layperson-friendly way to make sense of and contextualize what we just lived through. -- Arianna Rebolini * BuzzFeed *Quarantine provides a buffer and a delay, offering space and time, between the known (healthy folks) and the dangerous (potentially contagious people). Its complicated nature is adeptly explored, including ethical concerns, legal and moral questions, and enforcement challenges . . . Fascinating reading. -- Tony Miksanek * Booklist *A riveting and timely look at how humanity has protected itself by isolating segments of its populations. . . Manaugh and Twilley cull their research into a concise and logical series of recommendations for future public health crises, grounded in a deep appreciation of the human impact of quarantining. * Publishers Weekly *Captivating . . . Manaugh and Twilley meld a global view of a timely subject with vividly detailed accounts . . . But a larger charm of this smart book lies in their ability to bring potentially dry topics to life . . . An infectiously appealing overview of efforts to contain the potentially infectious. * Kirkus Reviews *Until Proven Safe is the book of our historical moment - a provocative meditation on how society uses quarantine to define the boundaries of self and other when faced with the terrifying unknown. Startlingly timely, authoritatively researched, and electrifyingly written. -- Steve Silberman, author of NeuroTribes: The Legacy of Autism and the Future of NeurodiversityUntil Proven Safe combines history, geography, epidemiology, and the ethics of space exploration – how can this be – Because, as the authors explain in a very entertaining and wide-ranging way, quarantine, ironically enough, crosses borders of space and time to make a complex knot of stories. Timely, eye-opening, provocative – you will see the world differently after reading it. -- Kim Stanley Robinson, author of Ministry for the FutureWhat does it mean to isolate threats: people carrying diseases; the microbes, themselves; radioactive materials? For centuries the primary tool of isolation has been quarantine, and in this globe-trotting tale of history and today’s COVID-19 crisis, Geoff Manaugh and Nicola Twilley offer answers that will make your jaw drop. Nothing about "quarantine" is as simple or straight-forward as you think. -- Laurie Garrett, author of The Coming Plague: Newly Emerging Diseases in a World out of BalanceAn engrossing study of the ways in which quarantines have changed social, emotional, and political life over hundreds of years, and a fascinating exploration of the perennial roles of fear, conspiracy theories, greed, and prejudice, to which we now add the threat of permanent digital surveillance in the name of public health. Perfect for our time and guidance for the future. -- Ellen Ullman, author of Close to the Machine and Life in CodeAs Twilley and Manaugh reveal in this timely but timeless, ambitious and flawlessly executed account, quarantines have shaped our history . . . The struggle to protect ourselves from invisible and deadly contagions is waged daily and largely out of sight - along borders and spore superhighways, in biosecure piggeries and nuclear waste facilities a half-mile underground. Quarantine: boring to live through, unbelievably interesting to read about. -- Mary Roach, author of Stiff and GruntStrap on your plague beaks and round up the loose women! In this intrepid, occasionally creepy jaunt through seven centuries of disease control, Twilley and Manaugh prove that the past is never dead; it’s just in quarantine. -- Alexis Coe, author of You Never Forget Your First: A Biography of George Washington

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Book Synopsis**THE SUNDAY TIMES BESTSELLER**'Brilliant! It's hard to change your life - but this book gives you all the reasons it's possible. From the first page to the last, one revelation after another.'JEREMY VINE'Brilliant . . . especially required reading in these COVID-19 days'LIZ EARLE'Metabolism, inflammation, and immunity are three sides of the same coin. Fix one and you fix them all. Dr Aseem Malhotra offers you a way to fix all three at once, and the solution is as easy as your fork.' PROFESSOR ROBERT LUSTIG, bestselling author of Fat Chance'This remarkable book will change your life. Beautifully written, it compiles in one place the health messages we all know make sense. PROFESSOR KAROL SIKORA, leading cancer specialist and Founding Dean, University of Buckingham Medical School'Read this book and follow the plan, it may save your life.' GURINDER CHADHA, OBE, director of Bend It Like Beckham'A crystal-clear roadmap to reverse the roots causes of our poor metabolic and immune health. It is the handbook of health for our time.' MARK HYMAN, New York Times bestselling author of Food Fix*******The simple, evidence-based diet plan to rapidly improve your metabolic health, help with normal immune function and likely reduce the risk of severe effects from Covid-19.Dr Aseem Malhotra is a leading NHS-trained cardiologist and a pioneer of lifestyle medicine. He has been at the forefront of citing the health conditions which make us vulnerable to the worst effects of Covid-19. Obesity, Type 2 diabetes and heart disease are high among them - and all indicators of poor metabolic health. The good news is that in just 21 days we can prevent, improve and even potentially reverse many of the underlying risk factors that exacerbate how infections, including Covid-19, affect us and improve our ability to recover from them. Giving us the evidence-based science behind the plan, Dr Malhotra shares how simple changes to our diet as well as daily exercise and stress relief can have remarkable results in improving our markers for metabolic health, even helping to put Type 2 diabetes into remission, reduce risk factors for heart disease, decrease weight and enhance vitality.Arguing for the huge benefits to global health of these highly effective lifestyle changes, he shows how just 21 days can help us to start the journey to lead a healthier and longer life.Trade Review'This valuable and timely book is a must read.' -- KIM PEARSON, Harley Street nutritionist * London Evening Standard *'You have to get immediately The 21 Day immunity plan and take action now.' * European Scientist *'Dr Aseem Malhotra is a quite remarkable man . . . his timely, evidence-based and brilliant new 21-day immunity plan is a perfect way to take the first step to transforming your life. I wish you well on your journey to better health.' -- From the Foreword by TOM WATSON'I've been unfortunate enough to have had #COVID19. I feel had I not focused on regaining my metabolic health and sending my type 2 diabetes into remission things could have been much worse. This amazing Doctor puts his head above the parapet. I have great respect for Dr Aseem Malhotra and owe my regained metabolic health to him.' -- DEBRA SCOTT, retired civil servant'Feel good today and increase your chance of living a longer and healthier life. In this well researched book Dr Malhotra provides the science and the steps for this double win.' -- DR CAMPBELL MURDOCH, Clinical Adviser, Royal College of GPs'This game-changing book is a must-read for anyone wishing to understand the link between metabolic health and immunity.' -- DR RAVI KUMAR KAMEPALLI, Board-Certified in Infectious Diseases, Wound Care and Obesity Medicine, Augusta, USA'Dr Aseem Malhotra spells it all out right here in front of you, with a perfect combination of smart, simple strategies for prevention or management of lifestyle conditions and keeping the immune system in best shape.' -- DR CARYN ZINN, Senior Lecturer, Dietitian, AUT University, Head of Research – School of Support and Recreation, Auckland, New Zealand'This groundbreaking book empowers the reader with knowledge of the practical steps we can all take to improve our health status and protect ourselves against diseases of all kinds.' -- KIM PEARSON, Harley Street nutritionist'Brilliant . . . especially required reading in these COVID-19 days' -- Liz Earle

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Book SynopsisTrade Review"The authors make a passionate case for the link between climate change and emerging infectious diseases. These are two of the biggest threats facing humanity and in combination the risks are escalated even further. Raising awareness of this combined threat is an original, timely, and vital contribution. I am not aware of another book on this topic that comes close to this in terms of the breadth and depth of its ambition."--Ian Goldin, Professor of Globalisation and Development, University of Oxford "The Stockholm Paradigm provides a new perspective on how we should think about (and combat) emerging pathogens. The authors, all highly respected parasitologists, are well qualified to provide the historical context, broad synthesis, and contemporary urgency required for a shift in thinking, essentially away from reactive, for profit programs. A game changer for parasitology and public health efforts focused on emerging infectious diseases."--Joseph A. Cook, Professor of Biology, Curator of the Division of Mammals at the Museum of Southwestern Biology, University of New Mexico

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Book SynopsisA virologist's insight into how viruses evolve and why global epidemics are inevitableIn 1993 a previously healthy young man was drowning in the middle of a desert, in fluids produced by his own lungs. This was the beginning of the terrifying Sin Nombre hantavirus epidemic and the start of a scientific journey that would forever change our understanding of what it means to be human.After witnessing the Sin Nombre outbreak, Dr Frank Ryan began researching viral evolution and was astonished to discover that it's inextricable from the evolution of all life on Earth. From AIDS and Ebola to the common cold, Ryan explores the role of the virus within every ecosystem on the planet. His gripping conclusions shed new light on the natural world, proving that what doesn't kill you really does make you (and your species) stronger.Trade ReviewPraise for Virusphere: ‘A fascinating book that is well structured … absorbing … [and] makes an engrossing and fervent argument’ The Inquisitive Biologist Praise for Frank Ryan: 'Extremely well written … Frank Ryan has the page-turning and spine-chilling ability of a good novelist'Sunday Telegraph 'Ryan is very good at making technical matters comprehensible to the lay reader, but more impressive still is the away he conveys the intellectual excitement and elation of scientific discovery'Literary Review ‘Dr Ryan writes well in a difficult technical field, weaving the technicalities of scientific history, medicine, molecular biology and evolution into the human narratives … Very readable and disturbing’New York Times…

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Book SynopsisPBS fitness personality on Classical Stretch and creator of the fitness phenomenon Essentrics, Miranda Esmonde-White offers an eye-opening guide to anti-aging that provides essential tools to help anyone turn back the clock and look and feel younger no matter what age.Trade Review"Public TV stations and their viewers have responded enthusiastically to Miranda's workouts for more than a decade; and from a personal standpoint I have experienced and enjoyed the anti-aging benefits of her program, too!" -- Chris Funkhouser, VP, American Public Television "I started doing Miranda's workouts ten years ago, and now I recommend them to ALL of my patients, even for those with joint problems. It is safe, easy, convenient, and complete ... the total package!" -- Dr. Beth Barnett, Certified Chiropractic Sports Physician "Miranda Esmonde-White shows readers how we age at a cellular level, and what we can do to slow down and reverse this process. Her pioneering exercise program can help anyone, at any level, maintain a youthful body as we inevitably enter into later stages of life." -- Claudio Cuello, MD, Professor and Former Chair of Pharmacology, McGill University

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Book SynopsisThe breast cancer guide every woman needs for herself, her best friend, and her sister—a warm, practical, relatable handbook, that dispels the terror, taking you step-by-step through the process, from diagnosis to post-treatment.When Andrea Hutton was diagnosed with breast cancer, she wanted to know everything.Trade Review"Breast cancer survivor Hutton offers a wealth of insider knowledge on exactly what to expect,...[and] while there is no universal cancer experience, Hutton covers the most likely scenarios in detailed fashion with grace, empathy, and humor." -- Publishers Weekly "This book could be a lifesaver." -- Library Journal "Straightforward, often humorous, no-nonsense, step-by-step, tip-filled text. No single guide can be all inclusive...but Hutton's "Top Tips" will help many." -- Booklist "Bald Is Better With Earrings is exactly what its subtitle promises. In a chatty, girlfriend kind of way, Hutton unflinchingly describes [her journey]. Building on that experience, she offers advice to other patients." -- Washington Post

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Book SynopsisOffers a retrospective of the havoc-wreaking microbes of the past as well as an engrossing exploration of emerging threats, including a chapter on bioterrorism. This book helps readers discover what makes smallpox the most potentially devastating of all bioweapons, and how prepared we are to fight it.

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Book SynopsisTable of ContentsPart I: Principles of Virology 1. History and Impact of Virology 2. Classification of Viruses and Phylogenetic Relationships 3. Virion Structure and Composition 4. Virus Replication 5. Innate Immunity 6. Adaptive Immune Responses to Infection 7. Pathogenesis of Virus Infections 8. Patterns of Infection 9. Mechanisms of Viral Oncogenesis 10. Laboratory Diagnosis of Virus Diseases 11. Vaccines and Vaccination 12. Antiviral Chemotherapy 13. Epidemiology of Viral Infections 14. Control, Prevention, and Eradication 15. Emerging Virus Diseases Part II: Specific Virus Diseases of Humans 16. Poxviruses 17. Herpesviruses 18. Adenoviruses 19. Papillomaviruses 20. Polyomaviruses 21. Parvoviruses 22. Hepatitis B and Hepatitis Delta Viruses 23. Retroviruses 24. Reoviruses 25. Orthomyxoviruses 26. Paramyxoviruses 27. Rhabdoviruses 28. Filoviruses 29. Bunyaviruses 30. Arenaviruses 31. Coronaviruses 32. Picornaviruses 33. Caliciviruses 34. Astroviruses 35. Togaviruses 36. Flaviviruses 37. Hepeviruses 38. Prions 39. Viral Syndromes

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Book SynopsisNathan Wolfe is the Lorry I. Lokey Visiting Professor in Human Biology at Stanford University and Director of Global Viral Forecasting, a pandemic early warning system which monitors the spillover of novel infectious agents from animals into humans. Wolfe has been published in or profiled by Nature, Science, The New York Times, The New Yorker, The Economist, Forbes and many others. Wolfe was the recipient of a Fulbright fellowship in 1997 and was awarded the National Institutes of Health (NIH) International Research Scientist Development Award in 1999 and the prestigious NIH Director's Pioneer Award in 2005.Trade ReviewNathan Wolfe is saving the world from near-inevitable pandemic ... a kick-ass book -- Mary Roach, author of StiffAn excellent piece of scientific gothic, rich in descriptions of the threat we face from emerging viruses ... thought-provoking * Nature *Part autobiography, part warning ... enthralling * BBC Focus *Quietly terrifying ... It's hard not to feel a bit feverish at times while reading * Boston Globe *Wolfe has an important story to tell and as a virologist at the forefront of pandemic forecasting, he is the perfect person to tell it. He explains the science clearly and never stoops to sensationalism - the evidence of our increasing vulnerability to pandemics speaks for itself * Guardian *The world's most prominent virus hunter * New Yorker *The plague-ridden future imagined by this authoritative, measured, yet gripping book is extremely alarming * Sunday Times *A good place to start preparing for what might come * New Humanist *

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Book Synopsis''A virtuoso feat ... a book of panoramic breadth'' New York Times Book Review''A devastating analysis ... Wright is a master of knitting together complex narratives'' The ObserverJust as Lawrence Wright''s The Looming Tower became the defining account of our century''s first devastating event, 9/11, so The Plague Year will become the defining account of the second.The story starts with the initial moments of Covid''s appearance in Wuhan and ends with Joseph Biden''s inauguration in an America ravaged by well over 400,000 deaths - a mortality already some ten times worse than US combat deaths in the entire Vietnam War.This is an anguished, furious memorial to a year in which all of America''s great strengths - its scientific knowledge, its great civic and intellectual institutions, its spirit of voluntarism and community - were brought low, not by a terrifying new illness alone, but by political incompeTrade ReviewA devastating analysis ... Wright is a master of knitting together complex narratives ... A story about hubris and division, complacency and insularity, but most of all precariousness. -- Andrew Anthony * The Observer *In his characteristically rigorous and engrossing style, Wright documents innumerable episodes of ineptitude and malfeasance ... Maddening and sobering - as comprehensive an account of the first year of the pandemic as we've yet seen. * Kirkus *Wright explains political mistakes and scientific breakthroughs, but The Plague Year has a more intimate register, too, in its record of how the virus upended everyday lives. The most heartbreaking moments are those that juxtapose ordinary people falling ill with the incompetence, negligence or politicking of the Trump White House ... The Plague Year suggests it was even worse than we remembered or realised at the time. -- Emily Tamkin * New Statesman *A virtuoso feat ... [Wright has] given us a book of panoramic breadth, [ranging] from science to politics to economics to culture with a commanding scrutiny, managing to surprise us about even those episodes we have only recently lived through and thought we knew well. The story he tells is immediate and often piercingly intimate ... Wright's storytelling dexterity makes all this come alive. -- Sonali Deraniyagala * New York Times Book Review *In his characteristic style, Mr Wright provides many small sketches of people touched by Covid-19 - from whizzy scientists like Barney Graham to victims like 96-year-old Jim Miller, a D-Day veteran who died of the disease in a cruelly mismanaged home for old soldiers. But the book's main character is Mr Trump, and its main service is in weighing his responsibility for the disaster. * The Economist *Arresting, lean-limbed, immersive ... Rich with peerless reportage and incisive critique ... Translates the complexities of epidemiology into plain English ... Wright is at his commanding best. -- Hamilton Cain * Minneapolis Star Tribune *Insightful ... Indispensable as a coronavirus compendium. Very little escapes Wright's notice, and he is adept at placing the ongoing story in an enlightening context. -- Michael King * Austin Chronicle *Taut, thriller-like, The Plague Year captures the chaos and courage of this unprecedented era that's forever changed us. * Oprah Daily *By far the best book yet on COVID-19 ... [An] exemplary chronicle [with] countless examples of hope, sacrifice, and heroic feats. Wright's interviews with experts in virology, economics, public health, history, politics, and medicine are enlightening ... Wright is at his finest here in frontline research, expert analysis, and lucid writing. -- Tony Miksanek * Booklist *[An] incredibly-crafted telling ... [Wright] is an earnest prober, with sober-minded curiosity ... [He] provides a well-wrought map covering the institutions and politicians that failed America during this stretch of the pandemic [and] crucially highlights those that also saved us - the first responders and the reasonable. -- Eric Allen Been * The Boston Globe *

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Book SynopsisThe most fatal virus known to science, rabies-a disease that spreads avidly from animals to humans-kills nearly one hundred percent of its victims once the infection takes root in the brain. In this critically acclaimed exploration, journalist Bill Wasik and veterinarian Monica Murphy chart four thousand years of the history, science, and cultural mythology of rabies. From Greek myths to zombie flicks, from the laboratory heroics of Louis Pasteur to the contemporary search for a lifesaving treatment, Rabid is a fresh and often wildly entertaining look at one of humankind''s oldest and most fearsome foes.A searing narrative.-The New York TimesIn this keen and exceptionally well-written book, rife with surprises, narrative suspense and a steady flow of expansive insights, ''the world''s most diabolical virus'' conquers the unsuspecting reader''s imaginative nervous system. . . . A smart, unsettling, and strangely stirring piece of work.-San Francisco ChronicleFascinating. . . . Wasik and Murphy chronicle more than two millennia of myths and discoveries about rabies and the animals that transmit it, including dogs, bats and raccoons.-The Wall Street JournalTrade Review“A searing narrative.”—The New York Times “In this keen and exceptionally well-written book, rife with surprises, narrative suspense and a steady flow of expansive insights, ‘the world’s most diabolical virus’ conquers the unsuspecting reader’s imaginative nervous system. . . . A smart, unsettling, and strangely stirring piece of work.”—San Francisco Chronicle “Fascinating. . . . Wasik and Murphy chronicle more than two millennia of myths and discoveries about rabies and the animals that transmit it, including dogs, bats and raccoons.”—The Wall Street Journal “Rabid delivers the drama of Louis Pasteur’s courageous work developing the rabies vaccine at the same time it details the disease’s place in our cultural history, taking us from Homer to the Bronte sisters to Zora Neale Hurston to Richard Matheson. . . . All along the book’s prose and pace shine—the book is as fast as the virus is slow.”—The Seattle Times “A very readable, fascinating account of a terrifying disease….Wasik and Murphy grippingly trace the cultural history of the disease. . . . Rabid reminds us that the disease is a chilling, persistent reminder of our own animal connections, and of the simple fact that humans don’t call all of the shots.”—The Boston Globe “Compelling. . . . Murphy and Wasik give life, context and understanding to the terrifying disease. Like the virus itself, this fascinating book moves quickly, exploring both the marginalized status and deadly nature of the virus. And as the authors trace the influence of rabies through history, Rabid becomes nearly impossible to put down.”—New Scientist “An elegant exploration of the science behind one of the most horrible way to die.”—Chris Anderson, author of The Long Tail “This book is not for the squeamish. Yet those who are fascinated by how viruses attack the body, by the history of vaccination and by physicians’ efforts to save the most desperately ill patients will want to read it. There is also a happy ending: scientists are working to harness rabies as a potent drug delivery vehicle.”—Scientific American “[Wasik and Murphy] offer an in-depth look at a disease so insidious that it even turns our best friends—dogs—against us. The pair convincingly link the history of rabies…with the history of man’s fear of nature and the unknown, and our own latent capacity for beastliness.”—The Daily Beast “Thrilling, smart, and devilishly entertaining, Rabid is one of those books that changes your sense of history—and reminds us how much our human story has been shaped by the viruses that live among us.”—Steven Johnson, author of The Ghost Map “Rabies has always been as much metaphor as disease, making it an excellent subject for cultural history. . . . As Wasik and Murphy document . . . the horror of rabies has been with us since the beginning of human civilization.”—Bookforum “Funny and spry. . . . It’s a rare pleasure to read a nonfiction book by authors who research like academics but write like journalists.”—Alice Gregory, n+1 “Readable, fascinating, informative, and occasionally gruesome, this is highly recommended for anyone interested in medical history or the cultural history of disease.”—Library Journal (starred review) “Take Bill Wasik, one of our most perceptive journalistic storytellers, have him join forces with Monica Murphy, scholar of public health, and you end up with this erudite, true-life creep show of a book. It turns out that the rabies virus is a good bit more fascinating and at least as frightening as any of those blood-thirsty monsters that have stalked our fairy tales, multiplexes, and dreams.”—Donovan Hohn, author of Moby Duck “Ambitious and smart.”—Publisher’s Weekly “Terrible virus, fascinating history in Rabid.”—NPR “As entertaining as they are on rabies in culture, the authors also eruditely report on medicine and public health issues through history, from ancient Assyria to Bali to Manhattan in the last five years, showing that while the disease may be contained, it may never be fully conquered. Surprisingly fun reading about a fascinating malady.”—Kirkus Reviews “The ultimate weird dad book.”—Very Short List “The rabies virus is a microscopic particle of genes and proteins. And yet it has cast a fearful shadow over all of human history. Bill Wasik and Monica Murphy have produced an eerily elegant meditation on disease and madness, dogs and vampires. It's as infectious as its subject.”—Carl Zimmer, NPR contributor and author of Parasite Rex “A fun read, rivaling a Stephen King novel for page-turning thrills.”—The Awl

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