Description
Book SynopsisSelected as a Doody's Core Title for 2022 and 2023! Defining the field of immunology for 40 years, Paul’s Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It’s an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.
Reflects the latest advances in the field, including current insights on immune system function, both basic and translational.
Contains 50 chapters written by leaders in all subfields of immunology.
Provides extensive coverage of the molecular biology that explains the dynamics underlying immune disorders and their treatment.
Includes 10 entirely new chapters covering invertebrate and plant immunity, eosinophils, innate lymphoid cells, gamma/delta T cells, NKT and MAIT cells, immunometabolism, maternal-fetal immunology and more.
Contains abundant full-color illustrations and tables that provide essential information at a glance.
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Features annual updates from the authors to the VST version, keeping you current with changes in this dynamic field from the experts.
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Table of ContentsContents Contributors vii
Foreword xiii
Preface xvii
Section I. Introduction to Immunology1 Overview of the Immune System — 1
Martin F. Flajnik, Steven M. Holland, Nevil J. Singh2 History of Immunology — 29
Edward J. Moticka Section II. Evolution of the Immune System3 The Insect Immune System — 52
Sara Cherry, Nicolas Buchon4 Evolution of the Vertebrate and Lower Deuterostome Immune System — 79
Martin F. Flajnik5 The Plant Immune System — 134
Roger W. Innes Section III. Cellular Pathways and Processes in Immunity6 Immunometabolism — 161
Jonathan D. Powell, Chirag H. Patel, Im- Hong Sun7 Regulated Cell Death in the Immune System — 204
Douglas R. Green, Sebastian Ruehl8 Lymphoid Tissues and Organs — 228
Martin F. Flajnik, Nancy H. Ruddle9 Type I Cytokines, Interferons, and Their Receptors — 258
Achsah D. Keegan, Warren J. Leonard10 Tumor Necrosis Factor Superfamily of Cytokines and Receptors — 308
Carl F. Ware, Nancy H. Ruddle11 Chemokines and Chemokine Receptors — 344
Philip M. Murphy Section IV. Innate Immunity12 Pattern Recognition Receptors and the IL- 1 Family — 386
Rajendra Karki, Thirumala- Devi Kanneganti13 The Complement System — 416
Erin E. West, Claudia Kemper14 Neutrophils — 455
Andres Hidalgo, Mariana J. Kaplan15 Macrophages — 469
Gwendalyn J. Randolph16 Mast Cells and Basophils — 487
Mindy Tsai, Stephen J. Galli17 Eosinophils — 519
Elizabeth A. Jacobsen, Hirohito Kita18 The Biology of Natural Killer Cells and Innate Lymphoid Cells — 537
Vincent Peng, Marco Colonna Section V. Adaptive Immunity19 The Major Histocompatibility Complex — 573
David H. Margulies, Kannan Natarajan, Jamie Rossjohn, James McCluskey20 Classical Antigen Processing and Presentation — 622
Jonathan W. Yewdell, Paul Roche, Laurence C. Eisenlohr21 Immunoglobulins: Structure and Function — 644
Mohamed Khass, David Wald, Neil S. Greenspan, Harry W. Schroeder, Jr22 Immunoglobulins: Molecular Genetics — 671
Sebastian D. Fugmann23 T Cell Antigen Receptors and Antigen Recognition — 702
Mark M. Davis, Yueh- Hsiu Chien24 Antigen Receptor Signaling — 734
Nevil J. Singh, Gideon Wolf 25 B Cell Development in Mice — 774
Nicole Baumgarth26 B Cell Responses — 798
Claude- Agnès Reynaud, Jean- Claude Weill27 T Cell Development in the Thymus — 823
Avinash Bhandoola, Remy Bosselut, Yousuke Takahama28 CD4+ Helper T Cells: Differentiation, Flexibility, and Heterogeneity — 856
John J. O’Shea, Marion Pepper, Marc K. Jenkins, Danielle A. Chisolm29 Regulatory T Cells — 874
Ethan M. Shevach30 CD8+ T Cell Memory — 924
Francis R. Carbone, Thomas Gebhardt31 Cytotoxic Effector Functions — 944
Morgan Huse Section VI. Integrative Immunology32 Immunologic Tolerance — 971
Colin C. Anderson, Troy A. Baldwin, Peter A. Bretscher33 Fc Receptors and Their Role in Immune Regulation and Inflammation — 1008
Jeffrey V. Ravetch, Aaron Gupta, Falk Nimmerjahn34 Dendritic cells — 1034
Roxane Tussiwand, Pierre Guermonprez, Simon Yona35 Gamma Delta T Cells — 1054
Adrian C. Hayday36 CD1- Restricted T Cells — 1102
Pankaj Sharma, Florian Winau37 Mucosal- Associated Invariant T Cells and Other MR1- Reactive T Cells — 1137
Sidonia B. G. Eckle, Wael Awad, Jamie Rossjohn, James McCluskey, Alexandra J. Corbett38 The Mucosal Immune System — 1178
Yasmine Belkaid, Brian L. Kelsall, Warren Strober39 Introduction to Neuroimmunology — 1212
Andrea Francesca Salvador, Jonathan Kipnis40 Vaccines — 1231
Bali Pulendran41 Maternal- Fetal Immunology — 1283
Gabrielle Rizzuto, Adrian Erlebacher Section VII. Immune Responses to Pathogens42 Response to Parasites — 1325
David Sacks, Marion Pepper, Mary F. Fontana, P’ng Loke43 Immune Responses to Bacteria — 1355
S. Celeste Morley, Moon H. Nahm44 Response to Viruses — 1399
Hildegund C. J. Ertl45 Immunology of HIV Infection — 1445
Gaurav D. Gaiha, Douglas S. Kwon Section VIII. Immunological Disease States and Immunodeficiency46 Autoimmunity and Autoimmune Diseases — 1465
Gustaf Christoffersson, Ken T. Coppieters, Matthias von Herrath, Dirk Homann47 Immunologic Mechanisms of Allergic Disorders — 1515
Stéphanie Lejeune, Kari C. Nadeau, David W. Scott, Joshua D. Milner48 Transplantation Immunology — 1549
Megan Sykes, Anita S. Chong, Markus Y. Mapara49 Cancer Immunology and Immunotherapy — 1589
Thomas F. Gajewski, Justin Kline50 Inborn Errors of Immunity — 1619
Isabelle Meyts, Jean- Laurent Casanova, Luigi D. Notarangelo Index 1649
