Molecular biology Books
Taylor & Francis Inc Clinical Microbiology
Book SynopsisThis concise, beautifully illustrated book provides a convenient introduction to the basic science of medical microbiology and how this relates to clinical practice. Expanded from the prize-winning first edition to cover virology and parasitology in addition to bacteriology, this second editions explains the essentials of microbial infection and continues to provide a sound basis for developing logical diagnostic and management strategies, including the critical area of antibiotic usage. Section One focuses on the clinical with chapters centred around infections of the organ systems, while full coverage of the scientific aspects underpinning microbial disease follows in Section Two. Table of ContentsSection One: Clinical Aspects of Microbial Infection. Introduction to Clinical Microbiology. Anti-Infective Guidelines in the Hospital. The Clinical Microbiology Laboratory. Preventing Disease and Infection Control. Infections of the Blood. Infections of the Urinary Tract. Infections of the Respiratory Tract. Tuberculosis. Infections of the Liver including Viral Hepatitis. Infections of the Nervous System. Infections of the Skin, Soft Tissues, Bones and Joints. Infections in a Modern Society. Section Two: Scientific Basis of Microbial Infection. The Structure and Function of Prokaryotic and Eukaryotic Cell. The Classification of Bacteria, Fungi and Parasites. The Structure and Replication of Viruses. How Organisms Cause Disease. The Science of Anti-infective Agents and Resistance. Appendix One: Notifiable Diseases. Appendix Two: Key Point Summary of Organisms and Conditions.
£40.84
Orion Publishing Co Scale: The Universal Laws of Life and Death in
Book SynopsisGeoffrey West's research centres on a quest to find unifying principles and patterns connecting everything, from cells and ecosystems to cities, social networks and businesses.Why do organisms and ecosystems scale with size in a remarkably universal and systematic fashion?Is there a maximum size of cities? Of animals and plants? What about companies?Can scale show us how to create a more sustainable future?By applying the rigour of physics to questions of biology, visionary physicist Geoffrey West found that despite the riotous diversity in the sizes of mammals, they are all, to a large degree, scaled versions of each other. This speaks to everything from how long we can expect to live to how many hours of sleep we need. He then made the even bolder move of exploring his work's applicability to cities and to the business world. These investigations have led to powerful insights about the elemental natural laws that bind us together in profound ways, and how all complex systems are dancing to the same simple tune, however diverse and unrelated they may seem.Trade Review'The sort of big-ideas book that comes along only every few years . . . This is a book full of thrilling ideas' * Sunday Times *'Magisterial . . . you reach the end of this profound, revealing book rewarded. West shows how scientific method helps to peel back the hidden reality of our world. The concepts of physics dominated the last century. It is the concepts of biology - of networks, evolution and feedback dynamics - that are going to dominate the next' -- Matthew Syed * The Times *'Quite dazzling . . . The book proceeds by introducing one mathematical concept in each chapter (power laws, fractals and so on), and explaining it vividly through numerous examples drawn from biology, history, urban planning, and many other fields . . . written with great joy and a disarming humility' -- Steven Poole * The Spectator *'An absolutely riveting read. Like the best detective story, West lays out the amazing challenge of understanding why animals, cities and companies all scale so uniformly and then skilfully lets us into the secrets that his detective work has uncovered. This book captures the spirit of science in the twenty-first century, revealing the deep connections not just across physics and biology but society and life. The book is a perfect balance between the big scientific story and West's own personal narrative. We accompany the author on his quest to face up to his own mortality while at the same time being exposed to the theoretical discoveries that West has pioneered in his groundbreaking work' -- Marcus du Sautoy, Simonyi Professor for the Public Understanding of Science at Oxford University and author of The Great Unknown 'This is an important and original book, of immense scope. Geoffrey West is a polymath, whose insights range over physics, biology and the social sciences. He shows that the sizes, shapes and lifetimes of living things - despite their amazing diversity - display surprising correlations and patterns, and that these follow from basic physical principles. He then discovers, more surprisingly, the emergence of similar 'scaling laws' in human societies - in our cities, companies and social networks. This fascinating book deserves a very wide readership' -- Lord Martin Rees, Astronomer Royal'Scaling is the most important yet most hidden and rarely discussed attribute -- without understanding it one cannot possibly understand the world. This book will expand your thinking from three dimensions to four. Get two copies, just in case you lose one' -- Nassim Nicholas Taleb'I can think of no more exciting thinker in the world today than Geoffrey West. By bringing a physicist's razor-sharp mind to wonderfully surprising questions - "Why Aren't There Mammals the Size of Tiny Ants?" or "Are Cities and Companies Just Very Large Organisms?" - West forces us to see everything anew, from our own bodies to the mega-cities our species increasingly chooses to inhabit. Scale is a firework display of popular science' -- Niall Ferguson'Trees, brains, hallucinogenics and even imaginary monsters are considered in this joyous, mind-boggling study of scientific methods' * Telegraph, Top 50 Best Books of 2017 *'An enchanting intellectual odyssey . . . also a satisfying personal and professional memoir of a distinguished scientist whose life's work came to be preoccupied with finding ways to break down traditional boundaries between disciplines to solve the long-term global challenges of sustainability . . . Mr West manages to deliver a lot of theory and history accessibly and entertainingly . . . Provocative and fascinating' * New York Times *'It's rare in the history of science that someone has a big, bold, beautiful, stunningly simple new idea that also turns out to be right. Geoffrey West had one. And Scale is its story' -- Steven Strogatz, Professor of Mathematics, Cornell University and author of The Joy of X 'Geoffrey West's Scale is a revelation. Based on his path-breaking theory and research on super-linear scaling, it provides powerful new insights into the basic scientific laws that power our modern society and economy, its start-up companies, large corporations and cities. The book is a must-read for CEOs, technologists, mayors, urban leaders and anyone who wants to understand the simple laws that shape the complex, self-organizing world in which we live' -- Richard Florida, author of THE RISE OF THE CREATIVE CLASS and a senior editor at THE ATLANTIC'Scale is filled with brilliant insights. West illuminates the laws of nature underlying everything from tiny organisms and humans to cities and companies, and provides a quantitative framework for decoding the deep complexity of our interconnected world. If you want to know why companies fail, how cities persist and what is needed to sustain our civilization in this era of rapid innovation, read this amazing book' -- Marc Benioff, founder and CEO of Salesforce'If there were a Nobel Prize for transdisciplinary science Geoffrey West would have won it for the work covered in Scale. This is a book of great originality and deep importance, containing startling insights about topics as seemingly unrelated as aging and death, sleep, metabolism, cities, energy use, creativity, corporations, and even the sustainability of our existence. If you are curious about how the world really works, you must read this book' -- Bill Miller, LMM Investments'This spectacular book on how logarithmic scaling governs everything is packed with news - from the self-similar dynamics of cells and ecosystems to exactly why companies always die and cities don't. I dog-eared and marked up damn near every page' -- Stewart Brand, creator of the WHOLE EARTH CATOLOG'When Geoffrey West, a brilliant theoretical physicist, turned his lens to the study of life spans, biological systems or cities he stumbled onto a game-changing universal insight about growth and sustainability. Scale is dazzling and provocative and West proves himself to be a compelling and entertaining writer - this is a book we will be talking about for a long time' -- Abraham Verghese, author of CUTTING FOR STONEThis book is breathtaking in its scope and vision! It represents the culmination of exciting theoretical work addressing critical questions in life. Written by a clever physicist and one of the most influential thinkers of the time, Geoffrey West, this volume elaborates on the author's intriguing discovery that the growth, organisation and dynamics of humans, animals and plants scale with their size. .....It is really an enjoyable readthat takes readers on a journey of fresh insights and illuminating perspectives. -- Walid El-Sharoud * SCIENCE PROGRESS *In this "grand unified theory of sustainability", physicist Geoffrey West explores underlying laws that link society and nature, called scaling theory. Insights (into city size and walking speed, for instance) abound -- Mary Craig * NATURE *
£10.44
Cambridge University Press Understanding EvoDevo
Book SynopsisWhy do the best-known examples of evolutionary change involve the alteration of one kind of animal into another very similar one, like the evolution of a bigger beak in a bird? Wouldn''t it be much more interesting to understand how beaks originated? Most people would agree, but until recently we didn''t know much about such origins. That is now changing, with the growth of the interdisciplinary field evo-devo, which deals with the relationship between how embryos develop in the short term and how they (and the adults they grow into) evolve in the long term. One of the key questions is: can the origins of structures such as beaks, eyes, and shells be explained within a Darwinian framework? The answer seems to be yes, but only by expanding that framework. This book discusses the required expansion, and the current state of play regarding our understanding of evolutionary and developmental origins.Trade Review'Wallace Arthur treats his readers to an eminently readable but still deeply rooted introduction into one of the most significant achievements of evolutionary biology: how evolutionary developmental biology put the organism back into the centre of evolutionary thinking.' Günter P. Wagner, Yale University, USA'Evo-devo deals with the multiple connections that exist between the biological processes of evolution and development. However, as an interface subject, there is a plurality of views on its content and its boundaries. In spite of that, Wallace Arthur has succeeded in writing an extremely clear and highly accessible guide to this fascinating, multifaceted discipline. Using the concept of 'developmental repatterning' as a common thread, the book provides a balanced view of evo-devo, covering its main achievements and future challenges. This is an ideal entry point for the non-specialist, but also a stimulating read for the practitioner who wants to consider her/his research in a wider perspective.' Giuseppe Fusco, University of Padova, Italy'Occasionally I feel that the field of Evolution and Development has lost its way, becoming submerged in myriad examples and details that don't expand our understanding of life. Wallace's book expounds the intellectual underpinnings of Evolution and Development, leads us through the key questions, and finally shows how the details and examples inform our future understanding. This book provides not just a guide to Evolution and Development, but also a spur to refocus and redouble our efforts to use development to help understand the evolution of life on Earth.' Peter Dearden, University of Otago, New ZealandTable of ContentsPreface; Acknowledgements; 1. What is evo-devo and why is it important?; 2. Antecedents of evo-devo; 3. Evolutionary and developmental essentials; 4. Evo-devo essentials; 5. The evolution of variations on a theme; 6. The evolutionary origins of themes and novelties; 7. The evolutionary origins of body plans; 8. Body plan features and toolkit genes; 9. Bringing it all together; Concluding remarks; Summary of common misunderstandings; References; Index.
£11.99
Harvard University Press The Black Box of Biology
Book SynopsisMichel Morange updates the history of molecular biology at a moment when scientists are making big strides in genetic engineering and exploring new avenues, from epigenetics to systems biology. Morange places the latest findings and ideas in historical context, describing in accessible terms how transformative the molecular revolution has been.Trade ReviewA clear and engaging overview of all the major developments and their interrelations. This is a very useful book that should be read by all scientists and anyone interested in the study of the molecular basis of life. -- Kostas Kampourakis * History and Philosophy of the Life Sciences *Anyone with serious pretentions to understand what went on in the middle of the last century in the field of molecular biology—discovery of the double helix, genetic code, going on a few decades later to the sequencing of human genome, and the rise of evolutionary development, ‘evo-devo’—simply must read this book. It is comprehensive, well written (excellently translated by Matthew Cobb), and simply absorbing. -- Michael Ruse * Quarterly Review of Biology *An important contribution to the big history of the molecular revolution and absolutely required reading for serious students of the huge impact it has had on biology. -- Koen B. Tanghe * Journal of the History of Biology *Readable and enjoyable…Instead of seeing molecular biology as a theoretical program of molecular reductionism, we get a messy science with ambiguous experiments and tinkering scientists, enabling the reader to experience all the excitement and frustration that accompanied the hidden life of molecular biology. -- Massimiliano Simons * Metascience *Michel Morange is our finest guide to the dramatic rise of molecular biology and its persistence in our lives through genetic engineering. Brilliant, clear, and nuanced, The Black Box of Biology will become a classic in the field. -- Oren Harman, author of The Price of Altruism and EvolutionsMorange’s re-elaboration of his 1998 masterpiece, A History of Molecular Biology, is a gift. Compelling and masterful in its command of contemporary biology, history, and philosophy, The Black Box of Biology is a key reference for grasping the scope and roots of human interventions in the biological world. -- Sabina Leonelli, University of ExeterAn original and expansive analysis of the history of molecular biology, from its origins to the rise of genomics and epigenetics. Unparalleled in its scope and insight, The Black Box of Biology should be required reading for historians and biologists seeking to understand the molecular transformation of modern biology. -- Michael Dietrich, University of PittsburghWritten by a historian of science trained in François Jacob’s laboratory, The Black Box of Biology weaves together the social, political, and scientific dimensions of the ‘molecular revolution’ into a compelling narrative and a fascinating read. -- Pierre-Olivier Méthot, Laval University
£34.81
Oxford University Press What is Life How Chemistry Becomes Biology Oxford
Book SynopsisSeventy years ago, Erwin Schrödinger posed a profound question: ''What is life, and how did it emerge from non-life?'' This problem has puzzled biologists and physical scientists ever since. Living things are hugely complex and have unique properties, such as self-maintenance and apparently purposeful behaviour which we do not see in inert matter. So how does chemistry give rise to biology? What could have led the first replicating molecules up such a path? Now, developments in the emerging field of ''systems chemistry'' are unlocking the problem. Addy Pross shows how the different kind of stability that operates among replicating molecules results in a tendency for chemical systems to become more complex and acquire the properties of life. Strikingly, he demonstrates that Darwinian evolution is the biological expression of a deeper, well-defined chemical concept: the whole story from replicating molecules to complex life is one continuous process governed by an underlying physical principle. The gulf between biology and the physical sciences is finally becoming bridged.This new edition includes an Epilogue describing developments in the concepts of fundamental forms of stability discussed in the book, and their profound implications.Oxford Landmark Science books are ''must-read'' classics of modern science writing which have crystallized big ideas, and shaped the way we think.Trade ReviewIn this inspiring book, Pross provides an engaging account of the view that systems chemistry can bridge the hitherto unassailable abiogenic/biogenic divide. In a carefully constructed, almost forensic, analysis, he confronts crucial issues, such as the conceptual gulf between the biochemist's chicken and egg problem...and the fundamental role of dynamic kinetic stability in the process of life. * Ben Mepham, The Biologist *Table of ContentsPrologue 1: Living things are so very strange 2: Historic quest for a theory of life 3: Understanding 'understanding' 4: Stability and instability 5: The knotty origin of life problem 6: Biology's crisis of identity 7: Biology is chemistry 8: What is Life? References and Notes Index
£11.39
HarperCollins Publishers Rosalind Franklin
Book SynopsisThe untold story of the woman who helped to make one of humanity's greatest discoveries DNA but who was never given credit for doing so.Our dark lady is leaving us next week.' On 7 March 1953 Maurice Wilkins of King's College, London, wrote to Francis Crick at the Cavendish laboratories in Cambridge to say that as soon as his obstructive female colleague was gone from King''s, he, Crick, and James Watson, a young American working with Crick, could go full speed ahead with solving the structure of the DNA molecule that lies in every gene. Not long after, the pair whose names will be forever linked announced to the world that they had discovered the secret of life.But could Crick and Watson have done it without the dark lady'? In two years at King's, Franklin had made major contributions to the understanding of DNA. She established its existence in two forms, she worked out the position of the phosphorous atoms in its backbone. Most crucially, using X-ray techniques that may have contr
£13.49
Callisto Reference Gel Electrophoresis: Basic Concepts and Principles
£89.99
Random House USA Inc Life on the Edge
Book Synopsis
£16.00
CRC Press Introduction to Protein Structure
Book SynopsisIntroduction to Protein Structure provides an account of the principles of protein structure, with examples of key proteins in their biological context generously illustrated in full-color to illuminate the structural principles described in the text. The first few chapters introduce the general principles of protein structure both for novices and for non-specialists needing a primer. Subsequent chapters use specific examples of proteins to show how they fulfill a wide variety of biological functions. The book ends with chapters on the experimental approach to determining and predicting protein structure, as well as engineering new proteins to modify their functions.Trade Review"The strength of the book lies in its beautiful art work and its logical dissection of the baffling complexities of protein structures…admirably concise, lucid and accurate presentations of difficult concepts…invaluable for students…" Nature"As an introduction to what proteins look like, how they fold up and how they interact with other molecules, large and small this book has no peer. It will be invaluable to students and research workers." Trends in Biotechnical Sciences"As usual, the distillation is authoritative and breathtaking." Tom Alber, University of California, Berkeley"It is superb. It gives a terrific overview, with great breadth and a proper and fair weight to the subject it treats." Ken Dill, University of California, San FranciscoTable of ContentsPART 1 BASIC STRUCTURAL PRINCIPLES 1. The Building Blocks 2. Motifs of Protein Structure 3. α-Domain Structures 4. α/β Structures 5. β Structures 6. Folding and Flexibility 7. DNA Structures PART 2 STRUCTURE, FUNCTION AND ENGINEERING 8. DNA Recognition in Procaryotes by Helix-Turn-Helix Motifs 9. DNA Recognition by Eukaryotic Transcription Factors 10. Specific Transcription Factors Belong to a Few Families 11. An Example of Enzyme Catalysis: Serine Proteinases 12. Membrane Proteins 13. Signal Transduction 14. Fibrous Proteins 15. Recognition of Foreign Molecules by the Immune System 16. The Structure of Spherical Viruses 17. Prediction, Engineering, and Design of Protein Structures 18. Determination of Protein Structures
£73.14
Elsevier Science Publishing Co Inc Molecular Biology
Book SynopsisTable of ContentsUnit 1: Basic Chemical and Biological Principles1. Cells and Organisms2. Basic Genetics3. DNA, RNA, and Protein4. Genes, Genomes, and DNA5. Manipulation of Nucleic Acids Unit 2: The Genome6. The Polymerase Chain Reaction7. Cloning Genes for Analysis8. DNA Sequencing9. Genomics and Systems BiologyNew Chapter to cover metagenomics, symbiosis, epigenomics etc Unit 3: The Central Dogma of Molecular Biology10. Cell Division and DNA Replication11. Transcription of Genes12. Processing of RNA (moved to Unit 4)13. Protein Synthesis14. Protein Structure and Function15. Proteomics: Global Analysis of Proteins Unit 4: Regulating Gene Expression16. Regulation of Transcription in Prokaryotes17. Regulation of Transcription in Eukaryotes12. Processing of RNA (moved from Unit 3)18. Regulation at the RNA LevelNew Chapter on Genome defense (RNAi and CRISPR). Would include their use in genetic analysis and genome editing19. Analysis of Gene Expression (Transcriptome) Unit 5: Subcellular Life Forms20. Plasmids21. Viruses22. Mobile DNA Unit 6: Changing the DNA Blueprint23. Mutations and Repair24. Recombination25. Bacterial Genetics26. Molecular Evolution
£102.60
Oxford University Press Biochemistry and Molecular Biology
Book SynopsisNow in its sixth edition, Biochemistry and Molecular Biology provides the perfect balance between detail and conceptual understanding. Maintaining the much-praised clarity of previous editions, this edition incorporates both new techniques and pivotal discoveries in a succinct, easy-to-digest way, using updated figures and diagrams to help explain complex processes.Updated content on the manipulation of DNA and genes reflects the rapid introduction of new methods in contemporary research, and incorporates up-to-date discussions of recent developments such as gene editing. Chapter summaries are logically laid out, forming bulleted lists which provide students with a consolidation of difficult concepts and progressively guide them through the specifics whilst keeping the big picture in mind. Additional ''find out more'' sections provide helpful problem-solving support and the further reading is divided into types to cater for broader learning needs.With an integrated approach covering boTrade ReviewEasy to read with good use of simple figures and plenty of internal cross-references to other chapters or relevant pages. I was impressed with the inclusion of some very up to date findings. * Dr Peter Morris, School of Life Sciences, Heriot-Watt University *I don't know of any other biology/biochemistry book that explains DNA replication as well as this one. * Lynn Rogers, School of Molecular and Biomedical Science, Adelaide University *The style is very clear, logical and systematic. The diagrams complement the text well. * Dr Momna Hejmadi, Department of Biology and Biochemistry, University of Bath *Good entry level biochemistry textbook that gives students an overview of the diversity of biochemistry and that introduces abstract concepts in a well-explained and accessible way. * Dirk Wildeboer, Natural Sciences, Middlesex University *This textbook presents classical biochemistry material with a balanced emphasis on details and conceptual understanding. Explanations are given in a conversational manner so that students are not distracted by an over-whelming amount of new terminology. * Amanda Storm, Biology, James Madison University *Table of ContentsPart 1: Basic concepts of life 1: The basic molecular themes of life 2: Cells and viruses 3: Energy considerations in biochemistryPart 2: Structure and function of proteins and membranes 4: The structure of proteins 5: Methods in protein investigation 6: Enzymes 7: The cell membrane and membrane proteins 8: Muscle contraction, the cytoskeleton, and molecular motorsPart 3: Metabolism and nutrition 9: General principles of nutrition 10: Food digestion, absorption and distribution to the tissues 11: The storage fuels: Mechanisms of transport, storage, and mobilization of carbohydrate and fat 12: Principles of energy release from food 13: Glycolysis, the TCA cycle, and the electron transport system 14: Energy release from fat 15: An alternative pathway of glucose oxidation: The pentose phosphate pathway 16: Synthesis of glucose (gluconeogenesis) 17: Synthesis of fat and related compounds 18: Nitrogen metabolism: amino acid metabolism 19: Nitrogen metabolism: nucleotide metabolism 20: Mechanisms of metabolic control and their applications to metabolic integration 21: Raising electrons of water back up the energy scale: photosynthesisPart 4: Information storage and utilization 22: The genome 23: DNA synthesis, repair and recombination 24: Gene transcription 25: Protein synthesis and controlled protein breakdown 26: Control of gene expression 27: Protein sorting and delivery 28: Manipulating DNA and genesPart 5: Cells and tissues 29: Cell signalling 30: The cell cycle, cell division, cell death and cancerPart 6: Protective mechanisms against disease 31: Blood clotting, xenobiotic metabolism, and reactive oxygen species 32: The immune system
£55.09
John Wiley & Sons Inc Molecular Cell Biology For Dummies
Book SynopsisTable of ContentsIntroduction 1 Part 1: The World of the Cell 5 Chapter 1: Exploring the World of the Cell 7 Chapter 2: Take a Tour inside the Cell 13 Chapter 3: Dead or Alive: Viruses 35 Part 2: Molecules: The Stuff of Life 51 Chapter 4: Better Living through Chemistry 53 Chapter 5: Carbohydrates: How Sweet They Are 77 Chapter 6: Proteins: Workers in the Cellular Factory 87 Chapter 7: DNA and RNA: Instructions for Life 103 Chapter 8: Lipids: Waterproof and Energy Rich 113 Part 3: The Working Cell 121 Chapter 9: Hello, Neighbor: How Cells Communicate 123 Chapter 10: Metabolism: Transferring Energy and Matter 139 Chapter 11: Cellular Respiration: Every Breath You Take 159 Chapter 12: Photosynthesis: Makin’ Food in the Kitchen of Life 187 Chapter 13: Splitsville: The Cell Cycle, Cell Division, and Cancer 203 Part 4: Genetics: From One Generation to the Next 219 Chapter 14: Meiosis: Getting Ready for Baby 221 Chapter 15: Genetics: Talkin’ ’Bout the Generations 233 Part 5: Molecular Genetics: How Cells Read the Book of Life 261 Chapter 16: DNA Replication: Doubling Your Genetic Stuff 263 Chapter 17: Transcription and Translation: What’s in a Gene? 273 Chapter 18: Control of Gene Expression: It’s How You Play Your Cards That Counts 291 Part 6: Molecular Biology: Harnessing the Power of DNA 311 Chapter 19: The Book of You: Reading Your Genes 313 Chapter 20: Rewriting the Code of Life: Recombinant DNA Technology and Genome Editing 331 Part 7: The Part of Tens 349 Chapter 21: Ten Important Rules for Cells to Live By 351 Chapter 22: Ten Ways to Improve Your Grade 361 Index 369
£17.09
Elsevier Science Sketches of Nature
Table of ContentsPrefaceIntroduction. Chapter 1. Sunfishes (Centrarchidae). Chapter 2. Livebearing Fishes (Poeciliidae). Chapter 3. Other Freshwater Fishes. Chapter 4. Pipefishes and Seahorses (Syngnathidae). Chapter 5. Other Marine Fishes. Chapter 6. The Mangrove Rivulus. Chapter 7. Amphibians. Chapter 8. Marine Turtles. Chapter 9. Freshwater Turtles. Chapter 10. Other Reptiles. Chapter 11. Birds. Chapter 12. Rodents. Chapter 13. Other Mammals. Chapter 14. Invertebrates. Chapter 15. Intergroup Comparisons
£25.19
Taylor & Francis Ltd Case Studies in Infectious Disease
Book SynopsisCase Studies in Infectious Disease presents 40 case studies featuring the most important human infectious diseases worldwide. Fully revised and updated in this second edition, the book describes the natural history of infection from point of entry of the pathogen through to clinical management of the resulting disease or condition. A further 8 case studies have been provided online as supplementary material, and these can be downloaded by students. Five core sets of questions are posed in each case, with the answers covering the nature of the infectious agent, route(s) of spread and of infection, pathogenesis of disease, host response to infection, clinical manifestations, diagnosis, treatment and prevention. This standardized approach provides the reader with a logical basis for understanding these diverse and medically important organisms and diseases, fully integrating microbiology and immunology throughout.KEY FEATURES High-resolution photos accompany each case, from the causative agents of disease to the clinical manifestations of the infection. Exquisite artwork helps to illustrate important concepts throughout the book. Eight new cases added to this new edition, extending coverage of important infectious diseases of worldwide significance. A standardized set of core questions allows students to compare directly differences between microbes such as their structure, clinical manifestations, host response, pathogenesis and availability of vaccines. Questions and answers available online, test the readerâs understanding of each case study. The book provides essential case-based learning for undergraduate and graduate microbiology students, while medical students and trainee physicians will also find the up-to-date information on 48 globally important infectious diseases outlined in a clear, digestible form, invaluable during undergraduate studies and in future clinical practice. Trade Review"a handsome, excellent book on most common pathogens, with a clear orientation to immunology, physiopathology, and microbiology … It reads well and is an excellent textbook for medical students and a good source of illustrations, tables, and question ideas for teachers." Gary P. Wormser and Guillaume Béraud for Clinical Infectious Diseases."a valuable compilation of information on the most common diseases that cause illness and death worldwide. The presentation format with distinct sections makes it readable and well suited for either students just learning about the pathogens causing infectious disease or clinicians who need an update. The level of detail is well thought out and gives the reader a useful summary of each pathogen and disease state. The condensed presentations make it a good reference source for those with insufficient time to read through more detailed textbooks." Philip S. Brachman for Emerging Infectious Disease.Table of ContentsAspergillus fumigatus Borrelia burgdorferi and related species Campylobacter jejuni Candida albicansChlamydia trachomatis Clostridiodies difficile Cytomegalovirus Echinococcus spp. EnterovirusesEpstein-Barr virus Escherichia coli Giardia lamblia Helicobacter pylori Hepatitis B virus Hepatitis C virusHerpes simplex virus Histoplasma capsulatum Human immunodeficiency virus Influenza virus Leishmania spp. Leptospira spp. Listeria monocytogenes Mycobacterium leprae Mycobacterium tuberculosis Neisseria gonorrhoeae Neisseria meningitidis Norovirus Plasmodium spp. Respiratory syncytial virus Rickettsia spp. Salmonella typhi Schistosoma spp. Staphylococcus aureus Streptococcus pneumoniae Streptococcus pyogenes Toxoplasma gondii Trypanosoma spp.Trichophyton spp. and dermatophytesVaricella-zoster virus Wuchereria bancrofti Plus online cases:Bartonella bacilliformis BrucellaCoxiella burnetti Dengue virusEnterococcus faecalis and E. faeciumMycobacterium abscessusSARS-CoV-2 Streptococcus mitis
£47.49
Taylor & Francis Ltd Molecular and Cellular Biology of Viruses
Book SynopsisThis fully revised second edition of Molecular and Cellular Biology of Viruses leads students on an exploration of viruses by supporting engaging and interactive learning. All the major classes of viruses are covered, with separate chapters for their replication and expression strategies, and chapters for mechanisms such as attachment that are independent of the virus genome type. Specific cases drawn from primary literature foster student engagement. End-of-chapter questions focus on analysis and interpretation with answers being given at the back of the book. Examples come from the most-studied and medically important viruses such as SARS-CoV-2, HIV, and influenza. Plant viruses and bacteriophages are also included. There are chapters on the overall effect of viral infection on the host cell. Coverage of the immune system is focused on the interplay between host defenses and viruses, with a separate chapter on medical applications such as antiviral drugs and vaccine develop
£63.64
Royal Society of Chemistry Natural Product Biosynthesis: Chemical Logic and
Book SynopsisAuthored by leading experts in the enzymology of natural product biosynthesis, this completely revised and updated edition provides a description of the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era. Although some 500 000 – 600 000 natural products have been isolated and characterized over the past two centuries, there may be a 10-fold greater inventory awaiting immediate exploration based on biosynthetic gene cluster predictions. The approach of this book is to codify the chemical logic that underlies each natural product structural class as they are assembled from building blocks of primary metabolism. This second edition integrates many new findings into the sets of principles of the first edition that parsed categories of natural product chemistries into the underlying enzymatic mechanisms and the catalytic machinery for building the varied and complex end product metabolites. New chapters include evaluation of a core set of thermodynamically activated but kinetically stable metabolites that power both primary and secondary metabolic pathways. Also, after decades of uncertainty about the existence of various pericyclase classes, a series of genome mining, heterologous expression, and enzymatic activity characterization have validated a plethora of pericyclases over the past decade. The several types of pericyclases are involved in biosynthetic complexity generation of almost every major category of natural products. This text will serve as a reference point for chemists of every subdiscipline, including synthetic organic chemists and medicinal chemists. It will also be valuable to bioinformatic and computational biologists, pharmacognocists and chemical ecologists, and bioengineers and synthetic biologists.Table of ContentsMajor Classes of Natural Product Scaffolds and Enzymatic Biosynthetic Machinery; The Chemical Logic for Major Reaction Types; Polyketide Natural Products; Peptide Natural Products I: RiPPs; Peptide Natural Products II: Nonribosomal Peptides; Isoprenoids/Terpenes; Alkaloids I; Purine- and Pyrimidine-derived Natural Products; Phenylpropanoid Natural Product Biosynthesis; Alkaloids II: Indole Terpenes; Natural Product Oligosaccharides and Glycosides; Oxygenases, Thwarted Oxygenases, and Oxygen-dependent Halogenases; S-Adenosylmethionine; Pericyclases in Natural Product Biosynthesis; Natural Products Isolation and Characterization: Gene-independent Approaches; Natural Products in the Post Genomic Era
£94.99
Elsevier Science The Fungi
Book SynopsisTrade ReviewPraise for the First Edition:"The style of The Fungi shows that the authors are all experienced teachers, with skills of how to present material in a readable and attractive way...In summary, start using this in your courses if you are not already doing so - it is one of the best two tools around at this time" --David L. Hawksworth for Mycological Research, March 2003"...fills a gap between many textbooks of microbiology, biochemistry, genetics and ecology through covering topics specific to mycology that they often omit." --Meriel Jones for Microbiology Today, May 2002Table of Contents1. Diversity2. Cell biology and development3. Spore production, discharge and dispersal4. Genetics – variation, sexuality and evolution 5. Physiology and adaptation6. Molecular ecology7. Interactions with autotrophs – mutualisms8. Interactions with autotrophs – pathogens 9. Interactions with humans and other animals10. Interactions between fungi and other microbes11. Global change12. Biotechnology
£60.29
Elsevier Science Craniofacial Development
Trade ReviewPraise for the Series: "Outstanding both in variety and in the quality of its contributions." --NatureTable of ContentsPart-1 Craniofacial Morphogenesis and Regeneration: From Cells to Tissues to Organs 1. Craniofacial Muscle Development Inbal Michailovici, Tamar Eigler and Eldad Tzahor 2. Mandible and Tongue Development Carolina Parada 3. Cellular and Molecular Mechanisms of Palatogenesis Yu Lan, Jingyue Xu and Rulang Jiang 4. Genetic Influences on Temporomandibular Joint Development and Growth Robert J Hinton, J Jing and JQ Feng 5. Regulatory Mechanisms Driving Salivary Gland Organogenesis Belinda R. Hauser and Matthew P. Hoffman 6. The Development of the Calvarial Bones and Sutures and the Pathophysiology of Craniosynostosis Mamoru Ishii, Jingjing Sun, Man-Chun Ting and Robert E. Maxson 7. Tissue Interactions Regulating Tooth Morphogenesis and Renewal Anamaria Balic and Irma Thesleff 8. Stem Cells in to Toth Development, Repair and Regeneration Tian Yu, Ana Angelova Volponi, Rebecca Babb, Zhengwen An and Paul T Sharpe 9. Development and integration of the Ear Jennifer C. Fuchs and Abigail S. Tucker Part- 2 Craniofacial Patterning and Signaling Mechanisms 10. Zebrafish Craniofacial Development: A Window Into Early Patterning Lindsey Mork and Gage Crump 11. Regulation of Jaw Length During Development, Disease, and Evolution Richard A. Schneider 12. Facial Morphogenesis: Physical and Molecular Interactions Between the Brain and Face Ralph Marcucio, Benedikt Hallgrimsson and Nathan M. Young 13. Developmental Plasticity of Patterned and Regenerating Oral Organs J. Todd Streelman, Ryan F. Bloomquist and Teresa E. Fowler 14. Regulating Craniofacial Development at the 3’ End: MicroRNAs and their Function in Facial Morphogenesis Andre L.P. Tavares, Kristin B. Artinger and David E. Clouthier 15. Transcription Factors in Craniofacial Development: From Receptor Signaling to Transcriptional and Epigenetic Regulation Yongchao Gou, Tingwei Zhang and Jian Xu Part- 3 Disease Models, Human Genetics, Genomics and Dynamic Imaging 16. Mouse Models of Rare Craniofacial Disorders Annita Achilleos and Paul A. Trainor 17. From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models Alice F. Goodwin, Rebecca Kim, Jeffrey O. Bush and Ophir D. Klein 18. Signaling Pathways in Craniofacial Development: Insights from Rare Skeletal Disorders Cynthia L. Neben and Amy E. Merrill 19. Clinical and Genomic Approaches for the Diagnosis of Craniofacial Disorders Pedro A.Sanchez-Lara 20. Morphometrics, 3D Imaging, and Craniofacial Development Benedikt Hallgrimsson, Christopher J. Percival, Rebecca Green ,Nathan M. Young, Washington Mio and Ralph Marcucio 21. Imaging the Cell and Molecular Dynamics of Craniofacial Development Le A. Trinh and Scott E. Fraser
£156.75
Elsevier Science Liver Regeneration
Book SynopsisTable of ContentsChapter 1. Introduction to Liver Regeneration: History and General Principles Chapter 2. Models to Study Liver Regeneration Chapter 3. Alternative Models to Study Liver Regeneration: Zebrafish Chapter 4. The Priming and Progression Theory of Liver Regeneration Chapter 5. Primary and Secondary Mitogen Theory of Liver Regeneration Chapter 6. Developmental Pathways in Liver Regeneration Chapter 7. Mechanisms of Termination of Liver Regeneration Chapter 8. Modulation of Extracellular Matrix During Liver Regeneration Chapter 9. Role of Chemokines Chapter 10. Role of Nuclear Receptors Chapter 11. Role of Developmental Morphogens in Liver Regeneration Chapter 12. Regulation of Cell Cycle during Liver Regeneration Chapter 13. Role of microRNAs and Long Non-Coding RNAs in Liver Regeneration Chapter 14. Changes in Hepatocyte Ploidy during Liver Regeneration Chapter 15. Role of Endothelial Cells in Liver Regeneration Chapter 16. Use of Computational Biology, Omics Technologies to Understand Liver Regeneration Chapter 17. Mitogen Induced Cell Proliferation in the Liver Chapter 18. Effect of Nutritional Diversity on Liver Regeneration Chapter 19. Introduction of Hepatic Progenitor Cells Chapter 20. Cellular Transdifferentiation in the Liver Chapter 21. Activation of Hepatic Progenitor Cells in Liver Regeneration After Chemical Injury to the Liver Chapter 22. Hepatic Progenitor Cells and iPS Cells as a Source of Mature Hepatocytes Chapter 23. Progenitor Cell Transplantation: Experimental Models Chapter 24. Liver Regeneration as a Therapy for Acute Liver Failure Chapter 25. Liver Regeneration Following Liver Transplantation Chapter 26. Hepatocyte Transplantation Therapy Chapter 27. Liver Regeneration: The Biliary Perspective
£106.20
Elsevier Science Evolution of Nervous Systems
Book Synopsis
£1,273.00
Elsevier Science Sexual and Reproductive Health
Book SynopsisTrade Review"In 1994 the United Nations International Conference on Population and Development (held in Cairo, Egypt) emphasized sexual and reproductive health services as central to sustainable development, and, additionally, developed a much expanded understanding of the issues. Human rights (and the right to good sexual and health services) came to the forefront, subsuming the notion that coercive measures to contain the population bomb could be justified. This volume presents current global thinking on physiology, general epidemiology, demography, the core elements of care, reproductive cancers, and some ethical and other general aspects." --Book News, Reference & ResearchTable of ContentsSection 1: Physiology, General Epidemiology and Demography Section 2: Core Elements Section 3: Reproductive Cancers Section 4: Ethics and other General Aspects
£84.79
Elsevier Science Stem Cell Proliferation and Differentiation
Book SynopsisTable of Contents1. Chromatin regulation and dynamics in stem cells David C. Klein and Sarah J. Hainer 2. Role of lncRNAs in stem cell maintenance and differentiation Meghali Aich and Debojyoti Chakraborty 3. Regulation of pluripotency and reprogramming by RNA binding proteins Dan Li, Mohamed S. Kishta and Jianlong Wang 4. Generating primed pluripotent epiblast stem cells: A methodology chapter Milan Samanta and Sundeep Kalantry 5. Differentiation of human pluripotent stem cells toward pharyngeal endoderm derivatives: Current status and potential Margaret E. Magaletta, Richard Siller and René Maehr 6. Epigenetic metabolites license stem cell states Logeshwaran Somasundaram, Shiri Levy, Abdiasis M. Hussein, Devon D. Ehnes, Julie Mathieu and Hannele Ruohola-Baker
£137.75
Elsevier Science Mechanisms of Cell Death and Opportunities for
Book SynopsisTable of Contents1. An overview of cell death in health and disease 2. Cell death:machinery and regulation 3. Molecular mechanisms of cell death: A brief overview 4. Major methods and technologies for assessing cell death 5. Proteotoxicity and endoplasmic reticulum stress-mediated cell death 6. Protein phase separation in cell death and survival 7. Therapeutics targeting the BCL-2 pathway 8. Ferroptosis: lipids, iron, cellualar defese mechanisms and opportunities for drug development
£103.50
Elsevier Science Chromatin
Book Synopsis
£88.19
Elsevier Science Publishing Co Inc Stiehms Immune Deficiencies
Book SynopsisTrade Review"This book is a fittingly titled, well-written publication. As a lengthy read, Stiehm's utility proves more to be as a comprehensive and informative reference book and guide for clinicians and any other readers interested in immunodeficiency. Readers will be able to easily navigate this well-organized text that provides outstanding details pertaining to immunodeficiencies and their common presentations, diagnostic approaches, and laboratory evaluations for diseases and a focused discussion on immunodeficiency management. Each chapter guides the reader by setting the tone with an overview or introduction, priming the reader for the in-depth text. Furthermore, the reader will find in-color illustrations, pictures, and imaging, which provides a visual aid in helping to solidify the understanding for the rare and complicated conditions discussed. In addition, of great value are the authors' use of tables that serve as an excellent quick reference for a plethora of topics ranging from various syndromes and their associated gene defects to therapeutic uses of vaccines in patients with immunodeficiency." --Annals of Allergy, Asthma and Imunology "With over 100 contributors, this current edition serves as a comprehensive resource on immunodeficiency disorders. It presents an up-to-date reference book with detailed information on all aspects of the subject. This authoritative collection is a reliable resource for practitioners, academicians, and researchers in the field." --Doody "Readers will indeed benefit from this fantastic reference book to help navigate the care of patients with rare conditions of inborn errors of immunity while understanding the genetic defects and pathophysiology of these conditions. Stiehm’s discussion of important clinical concepts bridges the gap between basic science immunology and how to apply it to the diagnosis and management of patients. The book is expertly written and will be an asset on the shelf of every immunologist." --Ann Allergy Asthma ImmunolTable of ContentsSection I. General Considerations Section II. Primary Immune Deficiencies Section III. Secondary Immune Deficiencies Section IV. Management
£212.50
Elsevier Science Publishing Co Inc Biotechnology and its Applications
Book SynopsisTable of ContentsUnit I – The cell 1. An introduction to biotechnology 2. Voyage into the cell 3. Proteins 4. Genes: the blueprints for proteins 5. Cell growth Unit II – Biotechnology in the laboratory 6. Microbial killing 7. Cell culture and the eukaryotic cells used in biotechnology 8. Fluorescence 9. Agarose gels 10. The polymerase chain reaction (PCR) 11. Genetic engineering Unit III – Biotechnology in the real world 12. Gene delivery 13. RNAi 14. Genome editing 15. DNA fingerprinting 16. Fermentation, beer, and biofuels 17. Stem cells, tissue engineering, and regenerative medicine 18. Transgenics and genetically modified organisms in agriculture 19. Patents and licenses
£77.39
Elsevier Science Tumor Immunology and Immunotherapy Cellular
Book SynopsisTable of Contents1. Cytokine profiling of tumor-infiltrating T lymphocytes by flow cytometry Jeremy B. Foote, Sujith Sarvesh and Leisha A. Emens 2. High-throughput identification of human antigen-specific CD8+ and CD4+ T cells using soluble pMHC multimers Morgane Magnin, Philippe Guillaume, George Coukos, Alexandre Harari and Julien Schmidt 3. In vitro assays for effector T cell functions and activity of immunomodulatory antibodies Roberta Zappasodi, Sadna Budhu, Mohsen Abu-Akeel and Taha Merghoub 4. A cytofluorimetric assay to evaluate T cell polyfunctionality Belinda Palermo, Mariangela Panetta, Giulia Campo and Paola Nisticò 5. Assessment of memory formation by metabolically engineered antigen-specific CD8 T cells Mathias Wenes, Pedro Romero and Lianjun Zhang 6. Functional characterization of tumor antigen-specific T-cells isolated from the tumor microenvironment of sleeping beauty induced murine glioma models Mahmoud S. Alghamri, Felipe J. Núñez, Neha Kamran, Stephen Carney, David Altshuler, Pedro R. Lowenstein and Maria G. Castro 7. Methods to edit T cells for cancer immunotherapy Francesca Lucibello, Silvia Menegatti and Laurie Menger 8. Generating stem-like memory T cells with antioxidants for adoptive cell transfer immunotherapy of cancer Karolina Pilipow, Eloise Scamardella and Enrico Lugli 9. Reverse immunology: From peptide sequence to tumor-killing human T-cell clones Christophe Vanhaver, Monica Gordon-Alonso, Alexandre Bayard, Maria Teresa Catanese, Didier Colau, Pierre van der Bruggen and Annika M. Bruger 10. Generation of TCR-engineered reference cell samples to control T-cell assay performance Nicole Bidmon, Cécile Gouttefangeas and Sjoerd H. van der Burg 11. In vitro expansion of V?9Vd2 T cells for immunotherapy Christian Peters, Léonce Kouakanou, Hans-Heinrich Oberg, Daniela Wesch and Dieter Kabelitz 12. CFSE dilution to study human T and NK cell proliferation in vitro Iñigo Terrén, Ane Orrantia, Joana Vitallé, Olatz Zenarruzabeitia and Francisco Borrego 13. Rapid isolation and enrichment of mouse NK cells for experimental purposes Maite Alvarez, Maria C. Ochoa, Luna Minute, Ignacio Melero and Pedro Berraondo 14. Assessment of NK cell-mediated cytotoxicity by flow cytometry after rapid, high-yield isolation from peripheral blood Peter Holicek, Iva Truxova, Lenka Kasikova, Sarka Vosahlikova, Cyril Salek, Jana Rakova, Monika Holubova, Daniel Lysak, Isabelle Cremer, Radek Spisek and Jitka Fucikova 15. Two-dimensional dynamic evaluation of natural killer cell-mediated lysis of adherent target cells Alexandra Frazao, Louise Rethacker and Anne Caignard 16. Rapid isolation of mouse ILCs from murine intestinal tissues Kyle Burrows, Pailin Chiaranunt, Louis Ngai and Arthur Mortha 17. Detecting and analyzing murine innate lymphoid cells Alejandra Gomez-Cadena, Pedro Romero, Sara Trabanelli and Camilla Jandus 18. A cytofluorimetric assay to evaluate intracellular cytokine production by NK cells Christian Sordo-Bahamonde, Seila Lorenzo-Herrero, Segundo González and Alejandro López-Soto 19. Applications of microfluidic devices in advancing NK-cell migration studies Xiaoou Ren, Abdulaziz Alamri, Jolly Hipolito, Francis Lin and Sam K.P. Kung 20. Complementary approaches to study NKT cells in cancer Jay A. Berzofsky, Purevdorj B. Olkhanud and Masaki Terabe 21. Assessment of IFN-? and granzyme-B production by in "sitro" technology Claudia Galassi, Gwenola Manic, Martina Musella, Antonella Sistigu and Ilio Vitale 22. Assessment of IFN? responsiveness in patient-derived xenografts Jordan J. Cardenas, Camila Robles-Oteiza and Katerina Politi 23. Real-time cell analysis (RTCA) to measure killer cell activity against adherent tumor cells in vitro Hans-Heinrich Oberg, Christian Peters, Dieter Kabelitz and Daniela Wesch 24. Analysis of cancer cell-intrinsic immune regulation in response to CD8+ T cell attack Natalie J. Neubert, Laure Tillé, Christophe Martignier, Silvia A. Fuertes Marraco and Daniel E. Speiser 25. A flow cytometry-based method to screen for modulators of tumor-specific T cell cytotoxicity Javier Santos, Jesús Ogando, Rosa Ana Lacalle and Santos Mañes 26. Evaluation of NK cell cytotoxic activity against malignant cells by the calcein assay Seila Lorenzo-Herrero, Christian Sordo-Bahamonde, Segundo González and Alejandro López-Soto 27. 51Cr-release to monitor NK cell cytotoxicity Leslie Elsner and Ralf Dressel
£138.00
Elsevier Science RNA Therapeutics
Book SynopsisTable of ContentsSECTION 1 The world of RNA therapeutics: Available RNA tools to modulate cellular processes 1. Targeting chromatin: Transcriptional gene activation (saRNA) 2. Argonaute and TNRC6, partners in RNAi 3. Targeted RNA therapeutics for treatment of cancer and immunomodulation 4. Extrahepatic delivery of RNA to immune cells SECTION 2 Learning from history 5. Aptamer-based protein inhibitors 6. Lessons learned from developing an oligonucleotide drug for a rare disease SECTION 3 Delivery 7. Nucleoside modifications of in vitro transcribed mRNA to reduce immunogenicity and improve translation of prophylactic and therapeutic antigens 8. SOMAmer reagents and the SomaScan platform: Chemically modified aptamers and their applications in therapeutics, diagnostics, and proteomics SECTION 4 From bench to bedside 9. CMC and regulatory aspects of oligonucleotide therapeutics 10. CMC: Regulatory landscape 11. CMC and manufacturing SECTION 5 From bench to bedside 12. RNA delivery for cancer gene therapy 13. Combinatorial RNA therapies in cancer immunotherapy: Challenges and directions
£130.50
Elsevier Science The Chlamydomonas Sourcebook
Book SynopsisTable of Contents1. Landmark Contributions of Chlamydomonas to Understanding Cilia 2. Basal bodies 3. Transition Zone 4. Dynein 5. Axonemal Dynein Preassembly 6. Ciliary Radial Spokes 7. Central pair 8. N-DRC 9. MIPS 10. Asymmetries 11. The Chlamydomonas ciliary membrane and its dynamic properties 12. Physics and mechanics of ciliary beating 13. IFT 14. Length control 15. Ciliary Disassembly 16. Deciliation 17. The Eyespot and Behavioral Light Responses 18. Ciliary adhesion and cilium-generated signaling during fertilization 19. Cytoskeleton
£121.50
Elsevier Science Fluorescent Probes
Book SynopsisTable of Contents1. Hydrogel microarray technology as a tool for clinical diagnostics Dimitry Gryadunov 2. The use of probes and bacteriophages for bacteria detection Jan Paczesny 3. Probes used with point-of-care microfluidic devices for pathogen detection Navid Rabiee 4. Methods for combining FIB/SEM with three-dimensional fluorescence microscopy using CLEM approaches Jost Enninga 5. Probes and Microbes Rishein Gupta 6. Microbial signatures associated with cancers Kishore Babu Challagundla 7. Fluorescent Aptamers for Detection and Treatment of Pathogenic Bacteria and Cancer Aarushi Sharma 8. Labelled and Unlabeled Probes for Pathogen Detection with Molecular Biology Methods and Biosensors Marisa Manzano 9. DNA/RNA-SIP Methods Huaiying Yao
£132.05
Penguin Books Ltd The Chemistry of Life
Book SynopsisFirst published in 1966, THE CHEMISTRY OF LIFE has held its own as a clear and authoritative introduction to the world of biochemistry. This fourth edition has been fully updated and revised to include the latest developments in DNA and protein synthesis, cell regulation, and their social and medical implications.
£11.69
Oxford University Press Insulin The Crooked Timber
Book SynopsisBefore the discovery of insulin, a diagnosis of Type 1 diabetes was a death sentence. One hundred years after a milestone medical discovery, ''Insulin - The Crooked Timber'' tells the story of how insulin was transformed from what one clinician called ''thick brown muck'' into the very first drug to be produced using genetic engineering, one which would earn the founders of the US biotech company Genentech a small fortune.Yet when Canadian doctor Frederick Banting was told in 1923 that he had won the Nobel Prize for this life-saving discovery, he was furious. For the prize had not been awarded to him alone - but jointly with a man whom he felt had no right to this honour. The human story behind this discovery is one of ongoing political and scientific controversy.Taking the reader on a fascinating journey, starting with the discovery of insulin in the 1920s through to the present day, ''Insulin - The Crooked Timber'' reveals a story of monstrous egos, toxic career rivalries, and a few Trade Review[uses] a blend of profound research, lively writing and personal knowledge of diabetes * Andrew Robinson, Nature *The lengthy bibliography and endnotes are a testament to the extensive research that has been carried out to produce this fascinating account. * Arpan K. Banerjee, Hektoen International *The story of insulin over the past 100 years, as the historian of science (and former molecular biologist) Kersten Hall shows in this dense and fascinating book, is also a microcosm of developments in science more widely, and of changes in the politics and economics of healthcare.[...] The pleasures of this book lie mainly in the storytelling detail and the gossipy richness of the lives, friendships and feuds glimpsed in the hubbub of decades pursuing the improvement of human health. * Steven Poole, Daily Telegraph *... comprehensive account of the modern medical history of the hormone... * Jerome Groopman, New York Review of Books *A fascinating book by an author with excellent credentials, well written and meticulously researched. * Geoff Gill, University of Liverpool *A timely book, pulling together many interesting stories about the scientific side of insulin. * John Pickup, King's College London School of Medicine *Reviews the events around the discovery of insulin in an original and well-documented manner. * Pierre Lefèbvre, University of Liège *Written in a clear and engaging style, the book provides a fresh take on historic events and also delves into aspects that have not been adequately explored previously. * Jeffrey Friedman, Rockefeller University *It is a good read and scholarly account. * Arpan Banerjee, Hektoen International Journal *Insulin-the Crooked Timber is essential reading for anyone concerned with the history of insulin. * Social History of Alcohol and Drugs. *Hall's The Crooked Timber expertly combines careful attention to the science with thoughtful consideration of its historical and philosophical dimensions. * Neelanjana Ray, History and Philosophy of the Life Sciences *Table of ContentsPreface Looking a Gift Horse in the Mouth? Introduction Taming the Tiger 1: The Pissing Evil - a colourful description of diabetes by 17th century English physician Thomas Willis 2: Thick Brown Muck - Canadian scientist Fred Banting wins the Nobel Prize for the discovery of insulin... and is furious 3: The Vision of Ezekiel - clinicians are stunned at the power of insulin to save lives, but it proves to be a double-edged sword 4: A Greek Tragedy - German clinician Georg Zuelzer snatches defeat from the jaws of victory 5: The Wasp's Nest - insulin proves to be a poisoned chalice for its discoverers 6: Be Careful What You Wish For - the case of Romanian scientist Nicolai Paulesco underlines the truth of an old proverb 7: 'In Praise of Wool' - the humble wool fibre sets in motion a revolution in biochemistry 8: A Boastful Undertaking - a discovery made in a fume-filled stable offers the key to unlocking insulin 9: The Blobs That Won a Nobel Prize - or two, all thanks to some coloured spots on a piece of filter paper 10: The Prophet in the Labyrinth - biochemist Erwin Chargaff helps unlock the secrets of DNA, but fears where this may lead 11: The Clone Wars - a conflict in which insulin proves to be a decisive weapon 12: Wall Street Gold - in an act of modern day alchemy, insulin makes stock market history 13: 'Don't You Want Cheap Insulin?' - What is it exactly that we want from science? And does the story of insulin have any lessons for us today? Bibliography Figures List and Acknowledgements for Images Acknowledgements End notes
£29.92
Oxford University Press The Molecular Vision of Life
Book SynopsisMolecular biology as a distinct scientific discipline had its origins in chemistry and physical biochemistry, gradually emerging in the period between 1930 and the elucidation of DNA in the mid 1950s. Today this field has risen to a dominant position, and with its focus on deciphering genetic structure, it has endowed scientists with unprecedented power over life. In this fascinating study, however, Lily Kay argues that molecular biology did not evolve in a random fashion but, rather, was the result of systematic efforts by key scientists and their supporting foundations to direct the development of biological research toward a preconceived vision of science and society. The author traces and analyses the conceptual roots of molecular biology and the social matrix in which it was developed, focusing on the role of leading researchers headquartered at Caltech, and on the Rockefeller Foundation''s sponsorship of the new science. The study thus explores a number of vital, sometimes controTrade Reviewthe book has the great merit to give insight in the expectation of young American scientists and in what troubles their minds! * Cellular and Molecular Biology, vol.43, no.5, July 1997 *Table of Contents1. "Social Control:" the Rockefeller Foundation's Agenda in the Human Sciences, 1913-1933 ; 2. The Technological Frontier: Southern California and the Emergence of Life Science at Caltech ; 3. Visions and Realitites: The Biology Division in the Morgan Era ; Interlude 1 - The Protein Paradigm ; 4. From Flies to Molecules: Physiological Genetics in the Morgan Era ; 5. A Convergence of Goals: From Physical Chemistry to Bio-Organic Chemistry ; 6. The Spoils of War: Immunochemistry and Serological Genetics, 1940-1945 ; 7. Microorganisms and Macromanagement: Beadle's Return to Caltech ; 8. The Molecular Empire
£59.40
Oxford University Press The Synaptic Organization of the Brain 5th Edition
Book SynopsisIt is widely recognized that the neural basis of brain function can be fully understood only by integrating many disciplines at many levels. Studies os synaptic organization are bringing about a quiet revolution in achieving this goal, as documented by this unique book over the past 30 years. In this fifth edition, the results of the mouse and human genome projects are incorporated for the first time. Molecular biologists interested in functional genomics and proteomics of the brain will find answers here to the critical questions: what are the cell and circuit functions of gene products? Also for the first time, the reader is oriented to supporting neuroscience databases.Among the new advances covered are 2-photon confocal laser microscopy of dendrites and dendritic spines, biochemical analyses, and dual patch and multielectrode recordings, applied together with an increasing range of behavioural and gene-targeting methods. Leading experts in the best understood brain regions bring toTrade ReviewThis fifth edition of Shepherd's well-respected text is still worth having on the bookshelf . . . the regions covered are dealt with systematically and clearly. Each chapter has a similar structure, with sections on the neuronal elements present, their synaptic connections and basic circuits, their intrinsic membrane properties, synaptic actions and dendritic properties, and the functional properties of the circuits. This is all done clearly and thoroughly, packing a great deal of information into a small space . . . The synaptic organisation of the brain is a classic text, and still very much worth having and reading for anyone interested in the details of neuroscience. * Physiology News, Number 56 *Table of Contents1. Introduction to Synaptic Circuits ; 2. Membrane Properties and Neurotransmitter Actions ; 3. Spinal Cord: Ventral Horn ; 4. Cochlear Nucleus ; 5. Olfactory Bulb ; 6. Retina ; 7. Cerebellum ; 8. Thalamus ; 9. Basal Ganglia ; 10. Olfactory Cortex ; 11. Hippocampus ; 12. Neocortex
£81.60
Oxford University Press The Way of the Cell Molecules Organisms and the Order of Life
Book SynopsisWhat is life? Fifty years after physicist Erwin Schrodinger posed this question in his celebrated and inspiring book, the answer remains elusive. In The Way of the Cell, one of the world''s most respected microbiologists draws on his wide knowledge of contemporary science to provide fresh insight into this intriguing and all-important question. What is the relationship of living things to the inanimate realm of chemistry and physics? How do lifeless but special chemicals come together to form those intricate dynamic ensembles that we recognize as life? To shed light on these questions, Franklin Harold focuses here on microorganisms - in particular, the supremely well-researched bacterium E. coli - because the cell is the simplest level of organization that manifests all the features of the phenomenon of life. Harold shows that as simple as they appear when compared to ourselves, every cell displays a dynamic pattern in space and time, orders of magnitude richer than its elements. It integrates the writhings and couplings of billions of molecules into a coherent whole, draws matter and energy into itself, constructs and reproduces its own order, and persists in this manner for numberless generations while continuously adapting to a changing world. A cell constitutes a unitary whole, a unit of life, and in this volume one of the leading authorities on the cell gives us a vivid picture of what goes on within this minute precinct. The result is a richly detailed, meticulously crafted account of what modern science can tell us about life as well as one scientist''s personal attempt to wring understanding from the tide of knowledge.Trade Review"The work is like a breath of fresh air in a scientific world otherwise obsessed with excessive reductionism."--BioEssays"Witty and erudite, this scientific book hails as a literary achievement. Comprehensive and up to date, Franklin Harold traces the roots--historical, thermodynamic, and biochemical--of today's biological revolution."--Lynn Margulis, co-author (with Dorion Sagan) of both What is Life? and What is Sex?"This book helps us understand why the search for answers to the riddle 'What is life?' is a noble quest."--Howard C. Berg, author of Random Walks in Biology
£16.64
Oxford University Press Biomolecular N.M.R. Spectroscopy
Book SynopsisThe technique of nuclear magnetic resonance (NMR) spectroscopy is an important tool in biochemistry and biophysics for the understanding of the structure and ultimately, the function of biomolecules. This textbook explains the salient features of biological NMR spectroscopy to undergraduates and postgraduates taking courses in NMR, biological NMR, physical biochemistry, and biophysics. Unlike other books in the general field of NMR (except the advanced treatises), the approach here is to introduce and make use of quantum mechanical product operators as well as the classical vector method of explaining the bewildering array of pulse sequences available today. The book covers two- dimensional, three- dimensional, and four- dimensional NMR and their application to protein and DNA structure determination. A unique feature is the coverage of the biological aspects of solid- state NMR spectroscopy. The author provides many selected examples from the research literature, illustrating the applTrade Review... written in a vibrant, enthusiastic style ... It will appeal to a wide readership, from undergraduate chemists ... biochemists and some biologists, to postdoctoral scientists working in this specialized field ... it is good value. * Chemistry in Britain, February 1996 *a very useful book ... I plan on using this book in my course for the foreseeable future and I highly recommend Biomolecular NMR Spectroscopy to you. * Kevin H. Mayo, University of Minnesota Health Sciences Center, Biophysical Journal, Volume 70, June 1996 *The author writes clearly and enthusiastically ... the strength of the book is its broad coverage of scores of applications of NMR to important biological problems ... Another positive aspect of Biomolecular NMR Spectroscopy is the care with which the author places NMR in the context of the larger scientific picture. * Patricia J. Lodi, nature structular biology volume 3 number 5 may 1996 *Table of ContentsPART 1: THEORY ; Introduction ; 1. Methods for spectral assignment - multidimensional NMR ; 2. Obtaining NMR structures ; PART II: PROTEINS ; 3. Protein structure ; 4. Protein folding ; PART III: ENZYMES ; 5. Enzyme function ; 6. Acyl and phosphoryl transfer enzymes ; 7. Other enzymes ; PART IV: NUCLEIC ACIDS AND CARBOHYDRATES ; 8. Nucleic acids and carbohydrates ; PART V: MEMBRANES ; 9. Structure of membranes and membrane proteins ; Appendix 1 Examples of product operator calculations ; Appendix 2 Useful NMR data on amino acid residues ; Appendix 3 Useful NMR data on oligonucleotide residues ; Appendix 4 Useful NMR data on common solvents ; Index
£97.25
Oxford University Press The Rise of Yeast
Book SynopsisYeast is humankind's favourite microbe, our partner in brewing, baking, and winemaking. Nicholas P. Money tells the story of this 10,000-year-long marriage, looking at how yeast served as a major factor in the development of civilization, celebrating its importance, and considering its future roles in molecular biology and genetic engineering.Trade ReviewA highly entertaining read ... a fascinating and lucid historical study, rich with biological intrigue. * Timothy James, Current Biology *The Rise of Yeast: How the sugar fungus shaped civilisation is an amazing story, about an amazing people-non-person relationship (and by an amazing writer): Surely, Moneys The Rise of Yeast is destined to be a classic and a thoroughly deserving award-winner! * Nigel Chaffey, Botany One, News and Views on Plant Biology and Ecology *The Rise of Yeast is a neat little book that elegantly covers a lot of ground. * Leon Vlieger, Inquisitive Biologist *Nicholas Money's effervescent tour is packed with delights, such as illustrations by Charles Tulasne, the Audubon of fungi, or the revelation that yeasts and humans share a common ancestor (and hundreds of genes). * Barabra Kiser, Nature *An enjoyable and readable account. * Brewer & Distiller International *Yeast rises our bread, ferments our beer, wine, and spirits, perfumes our fruit, nourishes our bodies, makes us bold in love, foments chaos, powers our cars, and unlocks the soul. We humans tend to think that we rule the earth, but the evidence on our behalf is scant. This fascinating book unlocks the mysteries of our world's true masters, which were here before we walked, will be here when we're gone, and, in the meantime, help make our time on the planet a lot more fun and infinitely more delicious. * Garrett Oliver, Brewmaster of the Brooklyn Brewery, Editor-in-Chief, The Oxford Companion to Beer *Table of ContentsNOTES; BIBLIOGRAPHY; INDEX
£20.24
Oxford University Press Redesigning Life
Book SynopsisSince the birth of civilisation, human beings have manipulated other life-forms. We have selectively bred plants and animals for thousands of years to maximise agricultural production and cater to our taste in pets. The observation of the creation of artificial animal and plant variants was a key stimulant for Charles Darwin''s theory of evolution. The ability to directly engineer the genomes of organisms first became possible in the 1970s, when the gene for human insulin was introduced into bacteria to produce this protein for diabetics. At the same time, mice were modified to produce human growth hormone, and grew huge as a result. But these were only our first tottering steps into the possibilities of genetic engineering.In the past few years, the pace of progress has accelerated enormously. We can now cut and paste genes using molecular scissors with astonishing ease, and the new technology of genome editing can be applied to practically any species of plants or animals. ''Mutation chain reaction'' can be used to alter the genes of a population of pests, such as flies; as the modified creatures breed, the mutation is spread through the population, so that within a few generations the organism is almost completely altered. At the same time, scientists are also beginning to synthesize new organisms from scratch.These new technologies hold much promise for improving lives. Genome editing has already been used clinically to treat AIDS patients, by genetically modifying their white blood cells to be resistant to HIV. In agriculture, genome editing could be used to engineer species with increased food output, and the ability to thrive in challenging climates. New bacterial forms may be used to generate energy. But these powerful new techniques also raise important ethical dilemmas and potential dangers, pressing issues that are already upon us given the speed of scientific developments. To what extent should parents be able to manipulate the genetics of their offspring and would designer babies be limited to the rich? Can we effectively weigh up the risks from introducing synthetic lifeforms into complex ecosystems? In this extensively revised paperback edition, John Parrington explains the nature and possibilities of these new scientific developments, which could usher in a brave, new world. We must rapidly come to understand its implications if we are to direct its huge potential to the good of humanity and the planet.Trade Reviewa thorough and comprehensive account of the methodologies for altering life that have been or are being developed, and the directions that they may take in future. * Nature *painstakingly researched...the examples themselves are clear, concise and often arresting . . . an engaging and comprehensive introduction * LSE Business Review *a comprehensive history of the research and discoveries underlying genome editing, as well as a broad coverage of research in the present day. * Bionews *There is a revolution going on in the life sciences, one that has already transformed scientific discovery and will soon change medicine. It could even see us altering the ecosystem in a precise, targeted way. This revolution has a name--CRISPR--and the key part of John Parrington's Redesigning Life is a good summary of the gene-editing technique that lies behind the acronym. * New Scientist *John Parrington's engaging and thoughtful book explains the science behind recent rapid advances in genetic engineering that mean it is increasingly possible to enact precise changes at a molecular level . . . Parrington's clear descriptions and diagrams combined with interesting snippets from the narrative and biography of scientific discovery make the science behind these developments readily accessible. * Socialist Review *Table of ContentsList of plates List of figures Introduction: The Gene Revolution 1: Natural Born Mutants 2: Supersize My Mouse 3: Light as a Life Tool 4: The Gene Scissors 5: Next Year's Models 6: The Molecular Farm 7: New Gene Therapy 8: Regenerating Life 9: Life as a Machine 10: A Redesigned Planet? Glossary Endnotes Index of names Index of subjects
£11.69
Oxford University Press The Man in the Monkeynut Coat William Astbury and
Book SynopsisSir Isaac Newton once declared that his momentous discoveries were only made thanks to having ''stood on the shoulders of giants''. The same might also be said of the scientists James Watson and Francis Crick. Their discovery of the structure of DNA was, without doubt, one of the biggest scientific landmarks in history and, thanks largely to the success of Watson''s best-selling memoir ''The Double Helix'', there might seem to be little new to say about this story. But much remains to be said about the particular ''giants'' on whose shoulders Watson and Crick stood. Of these, the crystallographer Rosalind Franklin, whose famous X-ray diffraction photograph known as ''Photo 51'' provided Watson and Crick with a vital clue, is now well recognised. Far less well known is the physicist William T. Astbury who, working at Leeds in the 1930s on the structure of wool for the local textile industry, pioneered the use of X-ray crystallography to study biological fibres. In so doing, he not only made the very first studies of the structure of DNA culminating in a photo almost identical to Franklin''s ''Photo 51'', but also founded the new science of ''molecular biology''. Yet whilst Watson and Crick won the Nobel Prize, Astbury has largely been forgotten. The Man in the Monkeynut Coat tells the story of this neglected pioneer, showing not only how it was thanks to him that Watson and Crick were not left empty-handed, but also how his ideas transformed biology leaving a legacy which is still felt today.Trade ReviewConstruction of the Watson-Crick model of DNA in the middle of the last century was a key event in scientific history. The surrounding controversies and the larger-than-life players have been widely described but continue to fascinate. By focussing on the lesser known figure of William Astbury, a pioneer in X-ray diffraction studies of biological fibres, this readable account brings a fresh interpretation and new insight. Astbury, widely regarded as a founder of molecular biology, is also shown to have had an understanding of protein structure that was ahead of its time, an understanding that helped create new textiles and a 'monkeynut' coat. * Iain Campbell, Department of Biochemistry, University of Oxford *This fascinating biography of the founder of molecular biology, the biocrystallographer Willam Astbury, reads like a detective story. Very rich in details, it paints a vivid picture of the scientific scene round Astbury, and reveals some unknown key aspects of the quest for the structure of DNA. * André Authier, Université Pierre et Marie Curie, Paris *The storyline works very well and I was gripped from the beginning to the end of the book. The author describes numerous stories that capture the human interest aspects of doing science, with its pains and its jubilations. * John R. Helliwell, University of Manchester *... an excellent, stylish historical account of the early days of biophysics. * The Biologist, Professor Jack Cohen FSB *Fascinating book. I particularly enjoyed reading about Astbury's background and impressive wide-ranging activities. * Jenifer Glynn, author of My Sister Rosalind Franklin *Hall''s book provides a useful historical corrective to the notion that all scientists are heroes; some of them are disappointed men. * The Guardian, Stephen Curry *In The Double Helix, James Watson wrote the Leeds scientist William Astbury out of the story of what, for many, is the greatest biological discovery of the twentieth century. With this superb book, Kersten Hall has written Astbury back in. The result is far more than the biography we have long needed of this colourful and creative pioneer of molecular biology (as Astbury was among the first to call it). In Hall's marvellously readable and deeply researched pages, the development of that science emerges as inseparable from the fortunes of the textiles industry — and from the misfortunes of a man who, like the monkeynut coat he helped to invent, disappeared into obscurity despite huge initial promise. * Gregory Radick, University of Leeds *...a fine piece of historical writing rich with illuminating detail and with real excitement for the subject. * The British Journal for the History of Science, Kenneth E. Hendrickson *A very persuasive argument ... I was left in no doubt that Astbury left the scientific world a better and more interesting place. * Rhys Baker, Bio News *Hall tells his story with style and pace. * Georgina Ferry, Nature *I have not been disappointed ... beautifully written and easy to read ... a job very well done. * John Jenkin, author of William and Lawrence Bragg, Father and Son: The Most Extraordinary Collaboration in Science *Very well-written and informative. * Gholson J. Lyon, Cold Spring Harbor Laboratory *Kersten Hall has brought into the limelight a normally unsung key player in the development of modern molecular and structural biology by writing this very engaging biography of William Astbury. * Elspeth Garman, University of Oxford *This is an excellent account of molecular biology and Astbury's role in its history. * Anthony C T North, Crystallography News *Table of Contents1: A Picture Speaks a Thousand Words 2: Germany Has Much to Teach us 3: A Keen Young Man 4: Into the Wilderness 5: The X-Ray Vatican 6: A Pile of Pennies 7: Avery's Bombshell 8: Nunc Dimittis 9: One Grand Leap ... Too Far 10: The Road Not Taken 11: The Man in the Monkeynut Coat
£19.99
Oxford University Press Biological Science
Book SynopsisA fresh approach to biology centred on a clear narrative, active learning, and confidence with quantitative concepts and scientific enquiry. Designed for flexible learning, it will give you a deeper understanding of the key concepts, and an appreciation of biology as a dynamic experimental science.Table of ContentsLife and its Exploration: Foundational Principles Topic 1: Exploring the science of life Topic 2: The emergence of life on Earth Topic 3: Defining Life Topic 4: Evolutionary processes Topic 5: The diversity, organisation, and classification of life Quantitative Toolkits Quantitative Toolkit 1: Understanding data Quantitative Toolkit 2: Size and scale Quantitative Toolkit 3: Describing data Quantitative Toolkit 4: Ratio and proportion Quantitative Toolkit 5: Understanding samples Quantitative Toolkit 6: Designing experiments Quantitative Toolkit 7: Assessing patterns Quantitative Toolkit 8: Formulae and equations Quantitative Toolkit 9: Rates of change Module 1 LIFE AT THE MOLECULAR LEVEL 1: Building blocks: molecules and macromolecules 2: Energy: powering biochemical processes 3: Information: genes and genomes 4: Mendelian genetics 5: Reading the genome: gene expression and protein synthesis 6: Proteins and proteomes 7: Metabolism: energy capture and release from food 8: Molecular tools and techniques Module 2 LIFE AT THE CELLULAR LEVEL 9: Characteristics of prokaryotic and eukaryotic cells 10: Cell division in prokaryotes and eukaryotes 11: Microbial diversity 12: The growth, measurement, and visualisation of cells 13: Microbes in life: harnessing their power 14: Microbes as agents of infectious disease 15: Viruses Module 3 THE HUMAN ORGANISM: TISSUES, ORGANS, AND SYSTEMS 16: Physiology overview 17: Communication and control 1: introducing the nervous and endocrine systems 18: Communication and control 2: sensory systems 19: Communication and control 3: controlling organ systems 20: Muscle and movement 21: Cardiovascular system 22: Respiratory system 23: Exercise physiology 24: Renal system 25: Digestive system 26: Reproductive system 27: Immune system
£46.54
Oxford University Press Molecular Biology
Book SynopsisThe biological world operates on a multitude of scales - from molecules to cells to tissues to organisms to ecosystems. Throughout all these levels runs a common thread: the communication and onward passage of information - from cell to cell, from organism to organism and, ultimately, from generation to generation. But how does this information - no more than a static repository of data - come alive to govern the processes that constitute life?The answer lies in the concerted action of molecular components which cooperate through a series of carefully-regulated processes to bring the information in our genome to life. These components and processes lie at the heart of one of the most fascinating subjects to engage the minds of scientists today: molecular biology.Molecular Biology: Principles of Genome Function offers a fresh, distinctive approach to the teaching of molecular biology. It is an approach that reflects the challenge of teaching a subject that is in many ways unrecognizable from the molecular biology of the 20th century - a discipline in which our understanding has advanced immeasurably, but about which many questions remain to be answered.It is written with several guiding themes in mind:- A focus on key principles provides a robust conceptual framework on which students can build a solid understanding of the discipline;- An emphasis on the commonalities that exist between the three kingdoms of life, and the discussion of differences between the three kingdoms where such differences offer instructive insights into molecular processes and components, gives students an accurate depiction of our current understanding of the conserved nature of molecular biology, and the differences that underpin biological diversity;- An integrated approach demonstrates how certain molecular phenomena have diverse impacts on genome function by presenting them as themes that recur throughout the book, rather than as artificially separated topicsAt heart, molecular biology is an experimental science, and a central element to the understanding of molecular biology is an appreciation of the approaches taken to yield the information from which concepts and principles are deduced. Yet there is also the challenge of introducing the experimental evidence in a way that students can readily comprehend.Molecular Biology responds to this challenge with Experimental Approach panels, which branch off from the text in a clearly-signposted way. These panels describe pieces of research that have been undertaken, and which have been particularly valuable in elucidating different aspects of molecular biology. Each panel is carefully cross-referenced to the discussion of key molecular biology tools and techniques, which are presented in a dedicated chapter at the end of the book.Beyond this, Molecular Biology further enriches the learning experience with full-colour, custom-drawn artwork; end-of-chapter questions and summaries; relevant suggested further readings grouped by topic; and an extensive glossary of key terms.Among the students being taught today are the molecular biologists of tomorrow; these individuals will be in a position to ask fascinating questions about fields whose complexity and sophistication become more apparent with each year that passes. Molecular Biology: Principles of Genome Function is the perfect introduction to this challenging, dynamic, but ultimately fascinating discipline.Trade ReviewThis is a comprehensive molecular biology textbook that emphasizes biochemical principles and molecular interactions... I believe that overall, it's the best text available for my students. * Donna E Crone, Rensselaer Polytechnic Institute *Conveys in-depth material in an easily digestible manner. Makes clear connections between different topics to improve understanding of key concepts. * Scott Bailey, Johns Hopkins University *This book would be excellent for a 300- or 400- level course and provides a nice entrée into using primary literature and experimental results in the lecture. * Harold Olivey, Indiana University Northwest *Table of ContentsGenomes and the flow of biological informationBiological moleculesThe chemical basis of lifeChromosome structure and functionThe cell cycleDNA replicationChromosome segregationTranscriptionRegulation of transcriptionRNA processingTranslationRegulation of translationRegulatory RNAsProtein modification and targetingCellular responses to DNA damageRepair of DNA double-strand breaks and homologous recombinationMobile DNAGenomics and genetic variationTools and techniques in molecular biology
£63.64
Oxford University Press Principles And Problems In Physical Chemistry For Biochemists
Book SynopsisAimed at the biochemistry undergraduates, this physical chemistry textbook covers a range of matters in a student-friendly manner, with a mix of information followed by worked examples that facilitate the absorption of the topics. It contains problems along with answers at the back of the book.Trade Review"Remarkably efficient [at] putting across conceptually difficult material ... Principles and Problems will continue to be essential reading for biochemistry undergraduates." The Biochemist, June 2002Table of ContentsINTRODUCTION ; THE ENERGETICS OF CHEMICAL REACTIONS ; THE RATES OF CHEMICAL REACTIONS ; ATOMIC AND MOLECULAR STRUCTURE ; APPENDICES
£37.99
Oxford University Press Cell Signalling
Book SynopsisWritten primarily for students embarking on an undergraduate bioscience degree, this primer provides a clear introduction to the main aspects of cell signalling in biological systems, demystifying the subject for those new to the field. The primer provides an overview of cell signalling and highlights its importance in all organisms, before going on to describe the main components of cell signalling and examples of signal transduction pathways. The discussion then progresses on to key physiological conditions in which cell signalling has an instrumental role: cancer, apoptosis and diabetes. After getting to grips with the fundamentals of the subject, Cell Signalling opens a discussion on the future of the discipline, including how manipulation of cell signalling pathways is seen as the biggest target for the pharmaceutical industry, and how crop diseases, plant survival during stress, and post-harvest storage are all influenced by cell signalling pathways.Cell Signalling is supported bTable of Contents1: Introduction to cell signalling 2: Signals and their perception 3: Modifications to proteins that control cell signalling 4: Intracellular signals 5: Cell signalling disorders; cancers and apoptosis 6: Stress responses and the changing cell environment 7: Future challenges and perspectives in cell signalling
£24.99
Oxford University Press Protein Structure and Function
Book SynopsisHow does the chemical description of a protein relate to its three-dimensional structure? How does the three-dimensional structure relate to the machinery that brings about a chemical reaction? How does the sequence of a gene encode not only the sequence of a protein but, more importantly, the architecture and function of that protein?Protein Structure and Function provides a clear and critical survey of our current understanding of the structure and function of proteins to answer questions such as these. Opening with a consideration of the link between protein sequence and structure, it goes on to explore the structural basis of protein function and how this function is controlled. Finally, it examines a range of case studies that illuminate the range of roles performed by proteins, and the diverse structures these proteins exhibit.Protein Structure and Function combines articulate prose with striking full colour illustrations, while the unique Primers in Biology modular structure intTrade ReviewA really good book provides a wealth of information in a manner that the reader remembers what he/she has read. This book does just that. The contents just pop into mind from time to time. This book will be a winner. * Tom Bruice, University of California, Santa Barbara *This treatment and focus is much needed. It will be essential reading by students and faculty alike, and will serve as a crucial reference book for everyone in the biosciences. * James Spudich, Stanford University School of Medicine *It is well-written, makes for interesting reading and contains a number of excellent examples. The whole book appears to be an important, useful and timely one. * Roman Laskowski, European Bioinformatics Institute *Table of Contents1. From Sequence to Structure ; 2. From Structure to Function ; 3. Control of Protein Function ; 4. From Sequence to Function: Case Studies in Structural and Functional Genomics ; 5. Structure Determination
£66.49
Oxford University Press Introduction to Glycobiology
Book SynopsisIntroduction to Glycobiology reveals the true impact of the sugars on biological systems, explaining their function at the molecular, cellular, and organismal level and their clinical relevance.Trade ReviewReview from previous edition This book is an absolute must for all lecturers and students alike of glycobiology ... Wholeheartedly recommended. * Microbiology Today, November 2006 *It covers the breadth of glycobiology very well and provides sufficient depth to provide a platform for further research. * Dr Gavin M. Brown, Lancaster University *Others are not written as clearly or concisely as Taylor and Drickamer. * Prof Y.C. Lee, John Hopkins University *I prefer this book highly above the other text books available. * Prof Dr J.P. Kamerling, Utrecht University *Dr Taylor and Professor Drickamer should be congratulated on writing a textbook that presents the enormous subject of glycobiology with energy and enthusiasm and doing so in a manner that should be accessible to their target audience. * Biochemist e-volution, April 2006 *Table of ContentsPART 1: STRUCTURES AND BIOSYNTHESIS OF GLYCANS; PART 2: GLYCANS IN BIOLOGY
£55.09
Oxford University Press, USA Building Bioinformatics Solutions 2nd edition
Book SynopsisThis book introduces the reader to all the key concepts and technologies needed to begin developing their own bioinformatics tools. The new edition includes more bioinformatics-specific content and a new chapter on good software engineering practices to help people working in teams.Table of Contents1. Introduction ; 2. Building Biological Databases with SQL ; 3. Beginning Programming in Perl ; 4. Numerical data analysis using R ; 5. Developing Web Resources ; 6. Software Engineering for Bioinformatics ; Appendix A: Using Command Line Interfaces ; Appendix B: Getting started with Apache HTTP Server ; Appendix C: Setting up a Linux Virtual Machine in Windows
£54.00
Oxford University Press Molecular Biology of RNA
Book SynopsisThe versatile RNA molecule, along with its many forms and functions, is elegantly captured in this succinct undergraduate text. Molecular Biology of RNA describes how RNA is not only an intrinsic part of the 'central dogma' of molecular biology, but also plays a part in processes as diverse as the regulation of gene expression and catalysis.Trade ReviewReview from previous edition Highly detailed, and well illustrated, ^Molecular Biology of RNA represents the first text to address exclusively the role of RNA in biological systems. * Kevin Coward in Journal of Biological Education, 2012 *This comprehensive textbook is pitched at just the right level and explains the concepts in sufficient detail to make them come to life. * Ilan Davis in Development, 2011 *Table of Contents1. Introduction to Molecular Biology of RNA ; 2. RNA can form versatile structures ; 3. Catalytic RNAs ; 4. The RNA-binding proteins ; 5. Pre-mRNA splicing by the spliceosome ; 6. Regulated alternative splicing ; 7. Pre-mRNA splicing defects in development and disease ; 8. Co-transcriptional pre-mRNA processing ; 9. Nucleocytoplasmic traffic of messenger RNA ; 10. Messenger RNA localization ; 11. Translation of messenger RNA ; 12. Stability and degradation of mRNA ; 13. RNA editing ; 14. The biogenesis and nucleocytoplasmic traffic of non-coding RNAs ; 15. The 'macro' RNAs: long non-coding RNAs and epigenetics ; 16. The short non-coding RNAs and gene silencing ; 17. RNA biology: future perspectives
£60.79
Oxford University Press The Neuron Cell and Molecular Biology
Book SynopsisThe Fourth Edition of The Neuron features newly updated chapters and scores of full-color figures, making it an ideal first course in the cell and molecular biology of nerve cells.Trade ReviewThe text is impressively modern, with up-to date information on the trendiest areas of neurobiology . . .the book is highly visual, with figures on virtually every page. The figures deserve special comment because they are a teacher's dream: simple and uncluttered, but conceptually powerful. Frankly, although the recommendation is often absurd, The Neuron is one of those books that really does belong on every shelf. * Nature *The format of each chapter is ideally suited for easy, enjoyable, and almost effortless learning . . . This is a superbly written and well-illustrated text covering all of the major aspects of neuroscientific knowledge . . . every neuroscientist should keep a copy handy. * Journal of Psychiatry and Neuroscience *This is a first-rate textbook for a course in cellular neurobiology for upper-level university students. My colleagues and I took it out on a shakedown cruise with a class of 250 undergraduates. The wind really caught their sails, and we sped quickly through it in the ten weeks of the academic quarter. The students appreciated the consistent clarity and the uniformity of style. The illustrations are highly conceptual and were easily understood . . . The up-to-date presentation of many exciting recent findings is a great strength. General principles are illustrated with a useful blend of data from vertebrate and invertebrate systems. * William S Messer, Jr., in The Quarterly Review of Biology *An outstanding, easily readable, and quite up-to-date overview of fundamental neurobiology. * Canadian Journal of Neurological Sciences *Table of ContentsPreface to the Fourth Edition ; I. Introduction ; 1. Signaling in the Brain ; 2. Form and Function in Cells of the Brain ; II. Electrical Properties of Neurons ; 3. Electrical Signaling in Neurons ; 4. Membrane Ion Channels and Ion Currents ; 5. Ion Channels Are Membrane Proteins ; 6. Ion Channels, Membrane Ion Currents, and the Action Potential ; 7. Diversity in the Structure and Function of Ion Channels ; III. Intercellular Communication ; 8. Intercellular Communication: How Neurons Communicate: Gap Junctions and Neurosecretion ; 9. Synaptic Release of Neurotransmitters ; 10. Neurotransmitters and Neurohormones ; 11. Receptors and Transduction Mechanisms I: Receptors Coupled Directly to Ion Channels ; 12. Receptors and Transduction Mechanisms II: Indirectly Coupled Receptor/Ion Channel Systems ; 13. Sensory Receptors ; IV. Behavior and Plasticity ; 14. The Birth and Death of a Neuron ; 15. Neuronal Growth and Trophic Factors ; 16. Adhesion Molecules and Axon Pathfinding ; 17. Formation, Maintenance, and Plasticity of Chemical Synapses ; 18. Intrinsic Neuronal Properties, Neural Networks and Behavior ; 19. Learning and Memory
£102.00
