Haematology Books

Book SynopsisAre you constantly exhausted? Does sleep not refresh you? Is your balance not what it was? Do you have tingling or even burning in your fingers and toes? Then your problem may be vitamin B12 deficiency. Your doctor may test you for this but your blood levels look OK so what should you do then? Or you may receive treatment but not feel any better? This book is a guide to the complexities of this deceptively simple problem - how it can be diagnosed, how it can be treated, and how those who have it can cope with the lifelong repercussions. Incorporating the latest research, and the input of the thousands of members of the Pernicious Anaemia Society, this book is both practical and engaging, illustrated with many personal stories that will resonate with sufferers and their friends and families.Table of ContentsIntroduction; Blood, Anaemia, Pernicious Anaemia and Vitamin B12 Deficiency; Causes of vitamin B12 deficiency; Problems with Assessing Vitamin B12 Deficiency; Problems with Diagnosing Pernicious Anaemia; Problems with the Treatment of Pernicious Anaemia; The consequences of pernicious anaemia; Associated health conditions; Current trends and future developments; Ten frequently asked questions

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book SynopsisThe Oxford Handbook of Clinical Haematology provides core and concise information on the entire spectrum of blood disorders affecting both adults and children. Updated for its fourth edition, it includes all major advances in the specialty, including malignant haematology, haemato-oncology, coagulation, transfusion medicine, and red cell disorders, with a brand new chapter on rare diseases. Practically focused, and specifically designed for ease-of-use, and rapid access to the information you need, this handbook is an indispensable resource on all aspects of haematology for all trainee doctors, nurses, technicians, and research professionals.The handbook is divided into clinical approach and disease-specific areas. The clinical approach section outlines various symptoms and signs in patients with blood disease to enable the reader to formulate a sensible differential diagnosis beofre embarking on investigation and treatment. The disease-specific section is written by four authors whose expertise covers the whole breadth of diseases included in the book. All authors have contributed to national guidelines (e.g. British Committee for Standards in Haematology, BCSH) and are experts in the evidence base that exists for each topic. The Oxford Handbook of Clinical Haematology offers a concise and logical approach to caring for patients with diseases of the blood.Trade ReviewThis new edition follows the tradition of the highly respected Oxford medical handbook series which is a compact, well produced book brimming with knowledge that will help the clinician in a large number of situations. * Dr Harry Brown, glycosmedia.com *Table of Contents1. Clinical approach ; 2. Red cell disorders ; 3. White blood cell abnormalities ; 4. Leukaemia ; 5. Lymphoma ; 6. Myelodysplasia ; 7. Myeloproliferative neoplasms (MPNs) ; 8. Paraproteinaemias ; 9. Haematopoietic stem cell transplantation (SCT) ; 10. Haemostasis and thrombosis ; 11. Immunodeficiency ; 12. Paediatric haematology ; 13. Haematological emergencies ; 14. Supportive care ; 15. Protocols and procedures ; 16. Haematological investigations ; 17. Blood transfusion ; 18. Rare diseases ; A1 Haematology online ; A2 Charts and nomograms ; A3 Normal ranges

Read more less

Book SynopsisTable of Contents1. Effective use of laboratory tests 2. Interpreting laboratory tests 3. The urea and electrolyte (U&E) profile - Sodium - Potassium - Bicarbonate - Chloride - Urea - Creatinine - Estimated glomerular filtration rate (eGFR) - Other tests of kidney function 4. The bone profile - Calcium - Phosphate - Albumin - Alkaline phosphatase (ALP) 5. The liver profile - Bilirubin - Alanine aminotransferase (ALT) - Aspartate aminotransferase (AST) - Gamma glutamyl transpeptidase (GGT) - Alkaline phosphatase (ALP) 6. Blood gas analysis and pH 7. Endocrine testing - Pituitary function - Adrenal function - Thyroid function - Gonadal function - Other hormones 8. Blood proteins 9. Enzymes 10. Glucose and other tests relevant to diabetes mellitus 11. Lipids and other tests relevant to cardiovascular disease 12. Tumour markers 13. Assessing nutrition 14. Heavy metals 15. Therapeutic drug monitoring 16. Poisoning 17. The full blood picture (FBP) - Haemoglobin - White cell count - Platelet count - Red cell indices - Blood film interpretation 18. Tests of coagulation 19. Blood grouping 20. Testing during pregnancy 21. Testing during childhood 22. Metabolic disorders 23. Analysis of body fluids other than blood - Urine - Pleural fluid - Peritoneal fluid - Cerebrospinal fluid - Synovial fluid

Read more less

Book SynopsisWritten by national recognized experts and senior fellows at leading research institutions, including the National Institutes of Health, and edited by Drs. Griffin P. Rodgers and Neal S. Young, The Bethesda Handbook of Clinical Hematology, 5th Edition, is a concise, comprehensive handbook designed for everyday clinical use. Organized in a quick-reference, portable format, it covers the clinical information you need to know for the diagnosis and treatment all of blood and bone marrow disorders. Readable and practical, the Bethesda Handbook features numerous tables, algorithms, illustrations, and bulleted lists throughout to help bridge the gap between cutting-edge science and everyday clinical practice. Provides clinically focused, authoritative, and current guidance in this complex area, logically organized by disease category Discusses the pathophysiology, natural history, risk factors, diagnosis, management, and follow-up of common hematological diseases Features new diagnostic and treatment strategies, updated references, and revised information throughout An ideal resource for practitioners at every level of training: students, residents, and fellows on a hematology or oncology service, as well as internists, hospitalists, family practitioners, pediatricians, and nurse practitioners whose practice includes patients with blood diseases

Read more less

Book SynopsisTable of ContentsSection 1: Introduction 1. Introduction to Peripheral Blood Film Examination Section 2: Hematopoiesis 2. Hematopoiesis 3. Erythrocyte Maturation 4. Megakaryocyte Maturation 5. Neutrophil Maturation 6. Monocyte Maturation 7. Eosinophil Maturation 8. Basophil Maturation 9. Lymphocyte Maturation Section 3: Erythrocytes 10. Variations in Size and Color of Erythrocytes 11. Variations in Shape and Distribution of Erythrocytes 12. Inclusions in Erythrocytes 13. Diseases Affecting Erythrocytes Section 4: Leukocytes 14. Nuclear and Cytoplasmic Changes in Leukocytes 15. Acute Myeloid Leukemia 16. Precursor Lymphoid Neoplasms 17. Myeloproliferative Neoplasms 18. Myelodysplastic Syndromes 19. Mature Lymphoproliferative Disorders 20. Morphologic Changes after Myeloid Hematopoietic Growth Factors Section 5: Miscellaneous 21. Microorganisms 22. Miscellaneous Cells 23. Normal Newborn Peripheral Blood Morphology 24. Body Fluids Glossary Appendix: Comparison Tables

Read more less

Book SynopsisThis broad and accessible introduction to the study of blood has been fully revised and updated to reflect advances in the field and in clinical practice, covering essential knowledge, from basic hematological physiology to blood disorders and their diagnosis and treatment.Trade Review“This book is an invaluable resource for medical students and health professionals wanting to consolidate and expand their knowledge of haematology.” (Kingbook73's Medical Ebook and Video Collection, 26 August 2014)Table of ContentsPreface to the fourth edition 6 Preface to the first edition 6 Glossary 7 Normal values 8 About the companion website 9 Part 1 Basic physiology and practice 1 Haemopoiesis: physiology and pathology 10 2 Normal blood cells I: red cells 14 3 Normal blood cells II: granulocytes, monocytes and the reticuloendothelial system 18 4 Normal blood cells III: lymphocytes 20 5 Lymph nodes, the lymphatic system and the spleen 23 6 Clinical assessment 24 7 Laboratory assessment 26 Part 2 Red cell disorders 8 General aspects of anaemia 30 9 Iron I: physiology and deficiency 33 10 Iron II: overload and sideroblastic anaemia 36 11 Megaloblastic anaemia I: vitamin B 12 (B 12) and folate deficiency – biochemical basis, causes 38 12 Megaloblastic anaemia II: clinical features, treatment and other macrocytic anaemias 40 13 Haemolytic anaemias I: general 42 14 Haemolytic anaemias II: inherited membrane and enzyme defects 44 15 Haemolytic anaemias III: acquired 46 16 Haemolytic anaemias IV: genetic defects of haemoglobin – thalassaemia 48 17 Haemolytic anaemias V: genetic defects of haemoglobin – sickle cell disease 52 Part 3 Benign disorders of white cells 18 Benign disorders of white cells I: granulocytes, monocytes, macrophages 54 19 Benign disorders of white cells II: lymphocytes, lymph nodes, spleen, HIV 56 Part 4 Haematological malignancies 20 Introduction to Haematological malignancy: basic mechanisms 58 21 General aspects of treatment 61 22 Acute leukaemia I: classification and diagnosis 64 23 Acute leukaemia II: treatment and prognosis 68 24 Chronic Myeloid Leukaemia (BCR-ABL1 positive) 70 25 Myelodysplasia (myelodysplastic syndromes) 72 26 Myeloproliferative disorders I: introduction 74 27 Myeloproliferative disorders II: polycythaemia rubra vera 76 28 Myeloproliferative disorders III: essential thrombocythaemia, primary myelofibrosis and systemic mastocytosis 78 29 Chronic lymphocytic leukaemia 80 30 Multiple myeloma and plasma cell disorders 83 31 Lymphoma I: introduction 86 32 Lymphoma II: Hodgkin lymphoma 88 33 Lymphoma III: non-Hodgkin lymphoma – aetiology and classification 90 34 Lymphoma IV: clinical and laboratory features of more common subtypes 92 35 Lymphoma V: treatment and prognosis 94 Part 5 Treatment and procedures 36 Bone marrow failure 96 37 Haematological effects of drugs 98 38 Stem cell transplantation 100 Part 6 Haemostasis 39 Normal haemostasis I: vessel wall and platelets 102 40 Normal haemostasis II: coagulation factors and fibrinolysis 104 41 Disorders of haemostasis I: vessel wall and platelets 106 42 Disorders of haemostasis II: inherited disorders of coagulation 108 43 Disorders of haemostasis III: acquired disorders of coagulation 110 44 Thrombosis and anti-thrombotic therapy 112 45 Anticoagulation 115 Part 7 Haematological aspects of tropical disease 46 Haematological aspects of tropical diseases 118 47 Haematology of pregnancy and infancy 120 Part 8 Blood transfusion 48 Blood transfusion I 122 49 Blood transfusion II 124 Appendix: cluster of differentiation nomenclature system 127 Index 129

Read more less

Book Synopsis'The test cases are particularly variable, including pertinent management tips in the answers. The book also contains a set of useful self-assessment questions. Being pedantic, this could now benefit from an increase in the proportion of 'Single Best Answer Questions', now ubiquitous in undergraduate assessment. This will continue to be on my local recommended reading list, particularly for those students wanting a thorough understanding of Haematology, from the laboratory through to basic management. It would also be a good text for those starting a career in Haematology, such as Physician Associates and doctors early in their training.'British Journal of HaematologyThis second edition of Haematology: A Core Curriculum is written by a haematologist with more than forty-five years of experience in teaching haematology to medical students and whose pedagogical and writing skills are widely admired within the field.The textbook takes a useful, practical approach, incorporating self-evaluation questions and learning objectives that give students the information needed to understand the topic and clear indications of the core knowledge required to progress within the field of haematology. Themes covered include clinical haematology and the scientific basis of the discipline and the causes and pathogenesis of haematological disorders as well as how conditions are diagnosed and treated.Haematology closely follows the Imperial College London curriculum but medical students, trainee nurses and biomedical science students from other institutions will find the textbook equally suitable, since it includes the core student haematology curriculum as recommended by the Royal College of Pathologists.Related Link(s)

Read more less

Book SynopsisSelected as a Doody’s Core Title for 2023! Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists. Provides expert coverage of new topics, including COVID-19, palliative care and survivorship, transitioning from pediatric to adult care, and ethical issues in hematology such as management of individuals with religious/cultural objections to transfusion Integrates WHO classifications of hematologic neoplasms and the latest knowledge in genetics and genomics, and includes focused chapters on hematopoietic cell transplantation, gene therapy, and immunotherapy Emphasizes four components of diagnosis: the morphology of the peripheral smear, bone marrow, lymph nodes, and other tissues; flow cytometry; cytogenetics; and molecular markers and mutations Offers fresh perspectives from new section editors Drs. John Leonard (Lymphoma) and Laura Michaelis (Leukemia/MPN), as well as numerous new contributing authors, many of whom provide international viewpoints on hematology Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Read more less

Book SynopsisTrade Review"It remains the worldwide standard in laboratory haematology and no haematologist should be without it!" "This is an excellent book for new learners or for experienced practitioners wanting an update/refresher. If you want a basic book covering all aspects of laboratory and clinical hematology, this is the one for you. If you are a student, this is a must have." -Valerie L. Ng, PhD MD (Alameda County Medical Center/Highland Hospital) Doody's Score: 94 - 4 Stars!Table of Contents1 Collection and handling of blood 2 Reference ranges and normal values 3 Basic haematological techniques 4 Preparation and staining methods for blood and bone marrow films 5 Blood cell morphology in health and disease 6 Supplementary techniques including blood parasite diagnosis 7 Bone marrow biopsy 8 Molecular and cytogenetic analysis 9 Iron deficiency anaemia and iron overload 10 Investigation of megaloblastic anaemia: cobalamin, folate and metabolite status 11 Laboratory methods used in the investigation of the haemolytic anaemias 12 Investigation of the hereditary haemolytic anaemias: membrane and enzyme abnormalities 13 Acquired haemolytic anaemias 14 Investigation of variant haemoglobins and thalassaemias 15 Erythrocyte and leucocyte cytochemistry 16 Immunophenotyping by flow cytometry 17 Diagnostic radioisotopes in haematology 18 Investigation of haemostasis 19 Investigation of a thrombotic tendency 20 Laboratory control of anticoagulant, thrombolytic and antiplatelet therapy 21 Blood cell antigens and antibodies: erythrocytes, platelets and neutrophils 22 Laboratory aspects of blood transfusion 23 Approach to the diagnosis and classification of blood cell disorders 24 Laboratory organisation, management and safety 25 Quality assurance 26 Haematology in under-resourced laboratories

Read more less

Book SynopsisWritten by global experts, this indispensable guide includes over 200 illustrations and essential information in clear tabular formatting, giving hematopathologists rapid access to diagnostic criteria at the microscope. General principles of bone marrow biopsy and aspirate processing are covered, together with the normal and reactive bone marrow, infective, infiltrative and neoplastic diseases. Chapters also guide readers through the use of immunohistochemistry, flow cytometry and molecular diagnosis, whilst extensive referencing provides further reading in specialist and rare topics. Whether working as a generalist, specialist, trainee or resident, this in an essential bench guide for hematopathologists at all levels of experience. The print book comes with access to the text and expandable figures online at Cambridge Core, which can be accessed via the code printed on the inside of the cover.

Read more less

Book SynopsisTable of ContentsPreface vii About the companion website ix 1 An introduction to haematopoiesis 1 2 The blood count in health and disease 15 3 Anaemia: general principles 23 4 Haemolytic anaemias 39 5 Disorders of globin synthesis 55 6 An introduction to haematological malignancies 71 7 Cellular and molecular investigations in haematology 79 8 Neoplastic disorders of myeloid cells 91 9 Neoplastic disorders of lymphoid cells 105 10 Plasma cell myeloma and other paraproteinaemias 121 11 Aplastic anaemia and pure red cell aplasia 131 12 Stem cell transplantation and cellular therapy 137 13 Haemostasis and bleeding disorders 147 14 Thrombosis and anticoagulant therapy 163 15 Blood groups and blood transfusion 173 Index 187

Read more less

Book SynopsisABC of Clinical Haematology An essential guide and introduction to the diagnosis, treatment and management of disorders across the breadth of clinical haematology Extensively revised, this 5th edition of ABC of Clinical Haematology covers all aspects of contemporary haematology, providing the basic science behind the disease and diagnostic aspects, along with up to date management. The text assumes little prior haematology knowledge, enabling clear understanding by non-experts, including medical students and nurses. Full colour illustrations and text boxes highlighting important learning points together enable more efficient reader comprehension. ABC of Clinical Haematology covers: Iron deficiency anaemia, macrocytic anaemia, hereditary anaemias, polycythaemia vera, essential thrombocythaemia, and myelofibrosis Chronic myeloid leukaemia, acute leukaemias, lymphoma, stem cell transplantation, cellular therapies, adult myelodysplastic syndrome, and myeloma Bleeding disorders, thrombosis, anticoagulation, and paediatric haematology, platelet disorders Amyloidosis, with focus on systemic light chain amyloidosis, and haematological emergencies New tests, treatments, and management solutions that are now available for certain conditions, especially common blood related disorders With contributions from leading experts in their respective fields, ABC of Clinical Haematology, Fifth Edition provides an ideal reference for primary care practitioners and other healthcare professionals working with patients who have blood related problems. About the ABC series The ABC series has been designed to help you access information quickly and deliver the best patient care, and remains an essential reference tool for GPs, junior doctors, medical students and healthcare professionals. Now offering over 80 titles, this extensive series provides you with a quick and dependable reference on a range of topics in all the major specialties. The ABC series is the essential and dependable source of up-to-date information for all practitioners and students in primary healthcare. To receive automatic updates on books and journals in your specialty, join our email list. Sign up today at www.wiley.com/emailTable of ContentsContributors iv Preface to the Fifth Edition v 1 Iron Deficiency Anaemia 1 Catherine Booth and Drew Provan 2 Macrocytic Anaemia 7 Samah Babiker and Nita Prasannan 3 The Hereditary Anaemias 13 Rachel Kesse- Adu 4 Polycythaemia Vera Essential Thrombocythaemia and Myelofibrosis 19 Anna L. Godfrey and Claire Harrison 5 Chronic Myeloid Leukaemia 25 Hugues de Lavallade 6 The Acute Leukaemias 31 Michael Austin and Bela Patel 7 Platelet Disorders 39 Marie A. Scully and John Paul Westwood 8 Adult Myelodysplastic Syndrome 47 Sally B. Killick 9 Myeloma and Other Plasma Cell Dyscrasias 53 Sally Moore and Karthik Ramasamy 10 Bleeding Disorders Thrombosis and Anticoagulation 59 Vickie McDonald 11 Lymphoma 65 Karen Stanley and David Wrench 12 Stem Cell Transplantation 81 Michelle Escebedo- Cousin and Kirsty Thomson 13 Cellular Therapies 87 Reuben Benjamin 14 Paediatric Haematology 91 John D. Grainger and Lianna Reynolds 15 Amyloidosis with a Focus on Systemic Light Chain Amyloidosis 101 Ayesha Shameem Mahmood 16 Haematological Emergencies 109 Vered Stavi and Igor Novitzky- Basso Index 119

Read more less

Book SynopsisIn malaria endemic areas, red cell polymorphisms that confer protection against acute uncomplicated malaria, severe malaria, and malaria mortality are widespread. However, the mode of selection favouring the red cell disorders and the precise mechanism of malaria protection remains unknown. In this book, the authors describe possible mechanisms by which the red cell disorders might confer resistance or susceptibility to human Plasmodium. This book shows how the interactions between Plasmodium species appear more evident through natural host protection or susceptibility and offer a good opportunity to better knowledge on this subject poorly understood. The authors have evaluated the consequences in vaccines development.

Read more less

Book SynopsisThis volume is the first of its kind to emphasize the visual approach in the diagnosis of cutaneous lymphoid infiltrates. Written and designed in an accessible yet highly detailed format by an expert in the field, this book bridges the knowledge gaps so often found when dealing with skin lymphomas. Complete with more than two hundred high quality images and illustrations, Diagnosis of Cutaneous Lymphoid Infiltrates offers pearls and pitfalls as well as differential diagnoses. Additionally, images are explained and decoded with the use of illustrations and analogies, proving to be an invaluable resource for pathologists, dermatologists, dermatopathologists, hematopathologists, and residents and fellows in these fields. Table of ContentsPart I: The Basics.- Clinical Pathological Correlation.- Skin Biopsy Evaluation.- Lymphocyte Morphology.- Lymphoid Follicle Morphology and Components.- Reactive Versus Neoplastic Lymphoid Follicles.- Extrafollicular Localization of Germinal Center Cells.- Part II: Histomorphologic Differential Diagnosis (DDx).- DDx of Epidermotropism.- DDx of Ulceration.- DDx of Perifollicular Accentuation.- DDx of Eosinophil-Rich Infiltrate.- DDx of Lymphoid Follicle Formation.- DDx of Angiocentrism.- DDx of Pannicular-based Infiltrate.- DDx of Large Cell Infiltrate.- Part III: Special Techniques.- Basic Immunohistochemistry Panels.- CD8-Positive Cutaneous Infiltrates.- Differential Diagnoses of CD30 Expression.- Differential Diagnoses of CD56.- EBV-positive Cutaneous Infiltrates.- Differential Diagnoses of BCL2-positive follicles.- Part IV: Diagnostic Entities.- Secondary Cutaneous Invovlement by Systemic/Nodal Lymphomas.- Classic Mycosis Fungoides (MF).- Folliculotropic Mycosis Fungoides (FMF).- Pagetoid Reticulosis.- Granulomatous Slack Skin.- Sezary Syndrome.- Primary Cutaneous CD30+ Lymphoproliferative Disorders, Primary Cutaneous Anaplastic Large Cell Lymphoma.- Primary Cutaneous CD30+ Lymphoproliferative Disorders, Lymphomatoid Papulosis.- Primary Cutaneous CD4+ Small/Medium-Sized Pleomorphic T-Cell Lymphoproliferate Disorder.- Subcutaneous Panniculitis-like T-cell Lymphoma (alpha-beta).- Cutaneous Gamma-Delta T-cell Lymphoma.- Primary Cutaneous Aggressive Epidermotropic CD8+ T-cell Lymphoma.- Extranodal NK/T-cell Lymphoma, Nasal Type.- Hydroa Vacciniforme-like T-cell Lymphoproliferative Disorder.- Adult T-cell Leukemia/Lymphoma (ATLL).- Primary Cutaneous Acral CD8+ T-cell Lymphoma (Indolent DC8+ Lymphoid Proliferation of the Ear).- Primary Cutaneous Peripheral T-cell Lymphoma, Unspecified.- Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type.- Primary Cutaneous Diffuse Large B-cell Lymphoma, Other.- Primary Cutaneous Follicle Center Lymphoma.- Primary Cutaneous Marginal Zone B-cell Lymphoma.- Lymphomatoid Granulomatosis (LYG).- Blastic Plasmacytoid Dendritic Cell Neoplasm.- Appendices.

Read more less

Book Synopsis

Read more less

Book SynopsisBlood is vital to most animals. In mammals it transports oxygen and food, carries away waste, and contains the white cells that attack invading microbes. Playing a central role in life, it has had profound cultural and historical significance and plays an important role in religious ritual. Blood was one of the four humours in early Western medicine and is still probably the major diagnostic tool in the doctor''s armoury. In this Very Short Introduction, Chris Cooper analyses the components of blood, explains blood groups, and looks at transfusions, blood tests, and blood-borne diseases. He considers what the future may hold, including the possibility of making artificial blood, and producing blood from stem cells in the laboratory.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.Trade ReviewBlood is over-flowing with such fascinating historical observations, as well as with an equally generous amount of practical information that everyone possessing blood should know. * The Well-Read Naturalist *Table of Contents1: A history of blood 2: What is blood? 3: Fighting Disease 4: Haemoglobin 5: Blood pressure and blood flow 6: Blood transfusion 7: Epilogue: the future of blood Further Reading Index

Read more less

Book SynopsisTable of Contents1 Laboratory Medicine 2 Statistical Methodologies in Laboratory Medicine 3 Quality Management in the Clinical Laboratory 4 Specimen Collection and Handling 5 Preanalytical Variations and Preexamination Processes 6 Quality Control 7 NEW! Standardization and Harmonization 8 Biological Variations 9 Reference Intervals 10 Evidenced-Based Lab Medicine 11 Biobanking 12 Lab Support of Pharmaceutical, In Vitro Diagnostics and Epidemiologic Studies 13 NEW! Machine Learning and Big Data 14 NEW! Utilization of Laboratory Tests 15 Lab Safety 16 Optical Techniques 17 Electrochemistry and Chemical Sensors 18 Electrophoresis 19 Chromatography 20 Mass Spectrometry 21 Sample Preparation for Mass Spectrometry Applications 22 Mass Spectrometry Applications in Infectious Disease 23 Mass Spectrometry for Small Molecule 24 Proteomics 25 Enzyme and Rate Analysis 26 Immunochemical Techniques 27 Microfabrication and Microfluidics 28 Cytometry 29 Automation in the Clinical Lab 30 Point-of-Care Testing 31 Amino Acids, Peptides, and Proteins 32 Serum Enzymes 33 Tumor Markers 34 Kidney Function Tests 35 Carbohydrates 36 Lipids and Lipoproteins 37 Electrolytes and Blood Gases 38 Hormones 39 Vitamins and Trace Elements 40 Iron Metabolism 41 Porphyrins and Porphyrias 42 Therapeutic Drug Management 43 Clinical Toxicology 44 Toxic Elements 45 Body Fluids 46 Nutrition 47 Diabetes Mellitus 48 Cardiac Function 49 Kidney Disease 50 Disorders of Water, Electrolytes, and Acid-Base Metabolism 51 Liver Disease 52 Gastric, Pancreatic & Intestinal Function 53 Monoamine Producing Tumors 54 Bone and Mineral Metabolism 55 Pituitary Function 56 Adrenal Cortex 57 Thyroid Disorders 58 Reproductive Endocrinology 59 Pregnancy and its Disorders 60 Newborn Screening and Inborn Errors of Metabolism (Small Molecules) 61 Newborn Screening and Inborn Errors of Metabolism (Large Molecules) 62 Principles of Molecular Biology 63 Nucleic Acid Isolation 64 Nucleic Acid Techniques 65 Genomes, Variants, and Massively Paralleled Methods 66 NEW! Clinical Genome Sequencing 67 Molecular Microbiology 68 Genetics 69 Solid Tumors 70 NEW! Hematopathology 71 Circulating Tumor Cells and Circulating Nucleic Acids in Oncology 72 Circulating Nucleic Acids for Prenatal Diagnostics 73 Pharmacogenetics 74 Hemostasis 75 NEW! Hemoglobin and Hemoglobinopathies 76 Automated Hematology 77 Red Blood Cell Morphology and Indices with Clinical Chemistry Interface 78 NEW! White Blood Cell Morphology 79 NEW! Platelets 80 NEW! Enzymes of the RBC 81 NEW! Overview of Infectious Disease 82 NEW! The Role of the Clinical Laboratory in Infection Prevention and Antimicrobial Stewardship 83 Bacteriology 84 Antimicrobial Susceptibility Testing 85 Mycobacteriology 86 Mycology 87 Parasitology 88 Virology 89 Blood Groups and Pretransfusion Testing 90 Blood Components, Products Modifications, and Blood Donor Screening 91 NEW! Indications for Transfusion: RBCs, platelets, plasma, and cryoprecipitate 92 NEW! Transfusion reactions/adverse events associated with transfusion 93 NEW! Allergy Testing 94 NEW! Immunogenicity of Biologics 95 NEW! Systemic Autoimmune Disease (ANA testing, RF, CCP, antibodies, etc. 96 NEW! Primary and secondary immunodeficiencies 97 NEW! Transplant 98 NEW! Immunogenetics Appendix Reference Information for the Clinical Laboratory

Read more less

Book SynopsisTable of ContentsTop 100 Secrets Diagnostic Approach to Anemia in Childhood Disorders of Hemoglobin, Normal Development Sickle Cell Syndromes Thalassemia Syndromes Anemia Secondary to Enzyme Deficiencies Anemia Secondary to Membrane Disorders Autoimmune Hemolytic Anemia Anemia Secondary to Nutritional Deficiencies Neonatal Anemia Normal Hemostasis Neonatal Hemostasis Disorders of Coagulation Disorders of Platelets Disorders of the Immune System Disorders of Granulocyte Function and Granulopoiesis Storage Disorders Hematologic Manifestations of Systemic Disease Bone Marrow Failure Syndromes Principles and Practice of Childhood Cancer Genetics, Molecular Genetrics Principles of Chemotherapy Principles of Surgical Oncology Principles of Radition Oncology for Pediatric Malignancy Acute Lymphoblastic Leukemia Acute Myelogenous Leukemia Myeloproliferative Disorders Non-Hodgkin's Lymphoma Hodgkin's Disease Lymphoproliferative Disorders Langerhans Cell Histiocytosis Tumors of the Central Nervous System Retinoblastoma Hepatic Tumors Wilms' Tumor Neuroblastoma Soft Tissue Sarcomas Bone Tumors Germ Cell Tumors Oncologic Emergencies Bone Marrow Transplant/PBSC Principles of Molecular Diagnostics and Therapeutic Supportive Care Late Effects of Childhood Cancer Psycho-social Aspects of Care of the child with Cancer Palliative Care Management of the Dying Child

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

Book Synopsis, For the most part we. the haemophiliacs present at this Congress. have come from the great metropolitan centres with their advanced medical and social programmes for sufferers of haemophilia. We. the fortunate from the haemophilia oasis. have much to learn from each other. This is important. but even more important is the urgency to convey your knowledge. your skills. your experience and your dedication to the haemophiliacs in the desert: 'We can only begin to understand the condition. the life of a sufferer. by comparing him to a soldier in the trenches of World War I. In the trenches the soldier seldom forgets that the next moment may bring death or crippling. The haemophiliac is literally in the trenches. The soldier may be spared injury. but pain awaits the haemophiliac. Fear. moreover, is paramount to the pain. As in the trenches. the anxiety can be more oppressive than the wound. Waiting to go over the top imposes a greater strain than the actual charge. For the soldiers that survived World War I in the trenches. 4 years seemed eternity; the haemophiliac never leaves the battlefield: Opening Address, Frank Schnabel. World Federation of Hemophilia. Copenhagen. June 25th. 1963. War can come to an oasis, peace can come to the trenches. With this book, Dr Peter Jones has joined the international struggle. Carefully, concisely and cogently. the text offers a grand strategy. With allies like Dr Jones we will, one day, achieve victory. Frank Schnabel, Chairman.Table of Contents1. The body—an introduction to structure and function.- 2. Bleeding and clotting.- 3. The causes of bleeding disorders.- 4. Bleeding episodes.- 5. Treatment 1—therapeutic materials.- 6. Treatment 2—treatment of bleeds; home therapy.- 7. Treatment 3—physiotherapy; aids; dental care.- 8. How a major operation is conducted in safety.- 9. Activities and precautions.- 10. Education and employment.- 11. Sex and family planning.- 12. Past, present and future.- Appendix: Aspirin and paracetamol.- Acknowledgements.

Read more less

Book SynopsisGeneral Information on Cancer Staging and End-Results Reporting.- Purposes and Principles of Cancer Staging.- Cancer Survival Analysis.- Head and Neck.- Lip and Oral Cavity.- Pharynx.- Larynx.- Nasal Cavity and Paranasal Sinuses.- Major Salivary Glands.- Thyroid.- Mucosal Melanoma of the Head and Neck.- Digestive System.- Esophagus and Esophagogastric Junction.- Stomach.- Small Intestine.- Colon and Rectum.- Anus.- Gastrointestinal Stromal Tumor.- Neuroendocrine Tumors.- Liver.- Intrahepatic Bile Ducts.- Gallbladder.- Perihilar Bile Ducts.- Distal Bile Duct.- Ampulla of Vater.- Exocrine and Endocrine Pancreas.- Thorax.- Lung.- Pleural Mesothelioma.- Musculoskeletal Sites.- Bone.- Soft Tissue Sarcoma.- Skin.- Cutaneous Squamous Cell Carcinoma and Other Cutaneous Carcinomas.- Merkel Cell Carcinoma.- Melanoma of the Skin.- Breast.- Breast.- Gynecologic Sites.- Vulva.- Vagina.- Cervix Uteri.- Corpus Uteri.- Ovary and Primary Peritoneal Carcinoma.- Fallopian Tube.- Gestational Trophoblastic Tumors.- Genitourinary Sites.- Penis.- Prostate.- Testis.- Kidney.- Renal Pelvis and Ureter.- Urinary Bladder.- Urethra.- Adrenal.- Ophthalmic Sites.- Carcinoma of the Eyelid.- Carcinoma of the Conjunctiva.- Malignant Melanoma of the Conjunctiva.- Malignant Melanoma of the Uvea.- Retinoblastoma.- Carcinoma of the Lacrimal Gland.- Sarcoma of the Orbit.- Ocular Adnexal Lymphoma.- Central Nervous System.- Brain and Spinal Cord.- Lymphoid Neoplasms.- Lymphoid Neoplasms.Trade ReviewFrom the reviews of the seventh edition:“Provide a new organ-specific classification that oncologists and other professionals who manage patients with cancer need in order to accurately classify tumours for staging. … a ‘Bible’ for oncologists, pathologists and surgeons, being also useful for all health officers, including general physicians and students, who want to remain updated in oncology. … this is a book that has to be present in all diagnostic imaging departments, as a major support to produce information adequate to the new oncology algorithms.”­­­ (Vincenzo Cuccurullo and Luigi Mansi, European Journal of Nuclear Medicine and Molecular Imaging, Vol. 38, 2011)Table of ContentsGeneral Information on Cancer Staging and End-Results Reporting.- Purposes and Principles of Cancer Staging.- Cancer Survival Analysis.- Head and Neck.- Lip and Oral Cavity.- Pharynx.- Larynx.- Nasal Cavity and Paranasal Sinuses.- Major Salivary Glands.- Thyroid.- Mucosal Melanoma of the Head and Neck.- Digestive System.- Esophagus and Esophagogastric Junction.- Stomach.- Small Intestine.- Colon and Rectum.- Anus.- Gastrointestinal Stromal Tumor.- Neuroendocrine Tumors.- Liver.- Intrahepatic Bile Ducts.- Gallbladder.- Perihilar Bile Ducts.- Distal Bile Duct.- Ampulla of Vater.- Exocrine and Endocrine Pancreas.- Thorax.- Lung.- Pleural Mesothelioma.- Musculoskeletal Sites.- Bone.- Soft Tissue Sarcoma.- Skin.- Cutaneous Squamous Cell Carcinoma and Other Cutaneous Carcinomas.- Merkel Cell Carcinoma.- Melanoma of the Skin.- Breast.- Breast.- Gynecologic Sites.- Vulva.- Vagina.- Cervix Uteri.- Corpus Uteri.- Ovary and Primary Peritoneal Carcinoma.- Fallopian Tube.- Gestational Trophoblastic Tumors.- Genitourinary Sites.- Penis.- Prostate.- Testis.- Kidney.- Renal Pelvis and Ureter.- Urinary Bladder.- Urethra.- Adrenal.- Ophthalmic Sites.- Carcinoma of the Eyelid.- Carcinoma of the Conjunctiva.- Malignant Melanoma of the Conjunctiva.- Malignant Melanoma of the Uvea.- Retinoblastoma.- Carcinoma of the Lacrimal Gland.- Sarcoma of the Orbit.- Ocular Adnexal Lymphoma.- Central Nervous System.- Brain and Spinal Cord.- Lymphoid Neoplasms.- Lymphoid Neoplasms.

Read more less

Book SynopsisHuman Blood Plasma Proteins gives an overview of the proteins found in human blood plasma, with special emphasis on their structure and function and relationship to pathological states and disease. Topics covered include: introduction to blood components and blood plasma proteins blood plasma protein domains, motifs and repeats blood plasma protein families and posttranslational modifications blood coagulation and fibrinolysis the complement system the immune system enzymes inhibitors lipoproteins hormones cytokines and growth factors transport and storage The information of each protein discussed in this book in some detail is summarised at the end of each chapter in a Data Sheet, where one can find the most important data of each protein at one glance. Full cross-referencing to protein databases is given and many of the proteins discussed are accompTrade Review"A major addition to the protein library, with an attractive and authoritative display of critical information about each plasma protein and a color schema of its three-dimensional structure from PDB." (The Quarterly Review of Biology, December 2009)Table of ContentsPreface. 1 Introduction. References. Part I. 2 Blood Components. 2.1 Introduction. 2.2 Short History. 2.3 Blood Components. References. Data Sheet. 3 Blood Plasma Proteins. 3.1 Introduction. 3.2 Short History. 3.3 Classification of Blood Plasma Proteins. References. Part II. 4 Domains, Motifs and Repeats. 4.1 Introduction. 4.2 The Epidermal Growth Factor (EGF)-Like Domain. 4.3 The Kringle Domain. 4.4 The g-Carboxyglutamic Acid-Rich (Gla) Domain. 4.5 The PAN/Apple Domain. 4.6 The Sushi/CCP/SCR Domain. 4.7 The Fibronectin Type I, the Fibronectin Type II Collagen-Binding and the Fibronectin Type III Domains. 4.8 The Coagulation Factors 5/8 Type C Domain (FA58C). 4.9 The Thrombospondin Type I Repeat (TSP1). 4.10 The VWFA, VWFC and VWFD Domains. 4.11 The Cystatin-Like Domain. 4.12 The LDL-Receptor Class A (LDLRA) and Class B (LDLRB) Domains. 4.13 The C-Terminal Cystine Knot (CTCK) Structure. 4.14 The Anaphylatoxin Domain. 4.15 The CUB Domain. 4.16 The NTR Domain. 4.17 The C-Type Lectin (CTL) Domain. 4.18 The Ig-Like Domain. References. 5 Protein Families. 5.1 Introduction. 5.2 Serine Proteases: The Trypsin Family. 5.3 Serine Protease Inhibitors (Serpins). 5.4 The a2-Macroglobulin Family. 5.5 The Serum Albumin Family. 5.6 The Pancreatic Trypsin Inhibitor (Kunitz) Family Signature. 5.7 The Kazal Serine Protease Inhibitors Family Signature. 5.8 The Multicopper Oxidase Family. 5.9 The Lipocalin Family. 5.10 The Globin Family. 5.11 The Glucagon/Gastric Inhibitory Polypeptide (GIP)/Secretin/Vasoactive Intestinal Peptide (VIP) Family. 5.12 The Glycoprotein Hormone Family. 5.13 Membrane Attack Complex Components/Perforin Signature (The Complement C6/C7/C8/C9 Family). 5.14 The Lipase Family. 5.15 Hormone Families and Signatures. 5.16 Growth Factor Families. 5.17 Cytokine Families. 5.18 Interleukin Families and Signatures. 5.19 The Small Cytokine (Intercrine/Chemokine) Family and Signature. References. 6 Posttranslational Modifications. 6.1 Introduction. 6.2 Databases for Posttranslational Modifications (PTMs). 6.3 Disulfide Bridges. 6.4 Glycosylation. 6.5 Phosphorylation. 6.6 Hydroxylation. 6.7 Sulfation. 6.8 Acylation and Alkylation. 6.9 Amidation. 6.10 Carboxylation. 6.11 Crosslinks. References. Part III. 7 Blood Coagulation and Fibrinolysis. 7.1 Introduction. 7.1.1 Definition of haemostasis. 7.2 Primary Haemostasis. 7.3 The Coagulation Cascade. 7.4 The Fibrinolytic System. 7.5 The Regulation of Blood Coagulation and Fibrinolysis. 7.6 The Kinin and Angiotensin/Renin Systems. References. Data Sheets. 8 The Complement System. 8.1 Introduction. 8.2 The Classical Pathway. 8.3 The Alternative Pathway. 8.4 The Terminal Components of the Complement System. 8.5 Components of Complement Activation. 8.6 Regulation of the Complement System. References. Data Sheets. 9 The Immune System. 9.1 Introduction. 9.2 Immunoglobulins. 9.3 Antibody Diversity. 9.4 Major Histocompatibility Complex (MHC) Proteins. 9.5 Innate Immune System. 9.6 Other Proteins. References. Data Sheets. 10 Enzymes. 10.1 Introduction. 10.2 EC 1: Oxidoreductases. 10.3 EC 2: Transferases. 10.4 EC 3: Hydrolases. 10.5 EC 5: Isomerases. References. Data Sheets. 11 Inhibitors. 11.1 Introduction. 11.2 Serine Protease Inhibitors (Serpins). 11.3 Blood Coagulation and Fibrinolysis. 11.4 The Complement System. 11.5 General Inhibitors. 11.6 Other Serpins. 11.7 Other Inhibitors. References. Data Sheets. 12 Lipoproteins. 12.1 Introduction. 12.2 Enzymes in Lipoprotein Metabolism. 12.3 Apolipoproteins. 12.4 LDL and VLDL Receptors. 12.5 Serum Amyloid A Proteins. References. Data Sheets. 13 Hormones. 13.1 Introduction. 13.2 Pancreatic Hormones. 13.3 Gastrointestinal Hormones. 13.4 Calcium-Related Hormones. 13.5 Hormone-Releasing Factors, Their Trophic Hormones and Related Hormones. 13.6 Vasopressin and Oxytocin. 13.7 Natural Opioid Peptides. 13.8 Vasoactive Peptides. 13.9 Erythropoietin and Thrombopoietin. 13.10 Others. References. Data Sheets. 14 Cytokines and Growth Factors. 14.1 Introduction. 14.2 Interleukin Families. 14.3 Tumour Necrosis Factor Family. 14.4 The Interferon Family. 14.5 Chemokines. 14.6 The Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor Family. 14.7 Transforming Growth Factor-b Family. 14.8 Miscellaneous. References. Data Sheets. 15 Transport and Storage. 15.1 Introduction. 15.2 The Serum Albumin Family. 15.3 The Globin Family. 15.4 Iron Transport and Storage. 15.5 Transport of Hormones, Steroids and Vitamins. 15.6 Other Transport Proteins in Plasma. References. Data Sheets. 16 Additional Proteins. 16.1 Introduction. 16.2 Additional Blood Plasma Proteins. Data Sheets. Appendix. Glossary. Index.

Read more less

Book SynopsisThis book has been highly successful ever since it was first published in 1958. Emphasis throughout is placed on diagnosis and management, with particular stress on clinical problems as they confront the practitioner. The new fifth edition has been completely revised and updated to take account of important recent developments such as AIDS, lymphomas and leukaemias, and in order to contain the length, some sections of the book have been condensed.Trade Review"Although this book is clearly orientated to bedside problems, it never fails to explain the usefulness and limitations of laboratory investigations. Such a book is probably needed even more now than it was in 1958 and ... this edition will continue to fill the need admirably ... it remains the best haematology reference for the general physician" British Medical JournalTable of ContentsPreface to Fifth Edition. Preface to First Edition. 1. Formation Blood Cells; Bone Marrow Biopsy. 2. The Red Cell; Basic Aspects of Anaemia. 3. Hypochromic Anaemia: Iron Deficiency and Siberoblastic Anaemia. 4. The Megaloblastic Anaemias. 5. Anaemia in Systemic Disorder; Diagnosis in Normochromic Normocytic Anaemia. 6. Pancytopenia; Aplastic Anaemias. 7. Disorders of Haemoglobin Structure and Synthesis. 8. The Haemolytic Anaemias. 9. White Cells: Neutrophilia and Eosinophilia; Neutropenia and Agranulocytosis; Infectious Monoucleosis. 10. The Leukaemias. 11. Tumours of Lymphiod Tissues; The Paraproteinaemias. 12. Polycythaemia; Myelofibrosis. 13. The Spleen: Hypersplenism and Splenomgaly. 14. The Haemorrhagic Disorder; Capillary and Platelet Defects. 15. Coagulation Disorder. 16. Thrombosis: Clinical Features and Management. 17. Blood Groups; Blood Transfusion; Acquired Immune Deficiency Syndrome. Index.

Read more less

Book SynopsisAccurate analysis of blood gases is vital to give information on a patient's respiratory and circulation state as well as the adequacy of resuscitation. This text guides the reader through the basic principles and a new system of interpretation.Table of ContentsHow to take an arterial blood gas sample; the survival guide to understanding acid-base balance; too much alkali; the survival guide to understanding oxygenation; too little oxygenation; complex situations; special situations; putting it all together; self assessments.

Read more less

Book Synopsis* Integrated textbook combining three subjects, haematology, clinical biochemistry and immunology to provide a one-stop text on blood science, in line with the new IBMS and NHS training structure * Suitable for blood science courses opening in many universities at senior Undergraduate level (units) and Masters level.Table of ContentsPreface, xiii Acknowledgements, xv List of Abbreviations, xvii About the Companion Website, xxi 1 Introduction to Blood Science, 1 1.1 What is blood science?, 1 1.2 Biochemistry, 6 1.3 Blood transfusion, 8 1.4 Genetics, 10 1.5 Haematology, 14 1.6 Immunology, 17 1.7 The role of blood science in modern healthcare, 19 1.8 What this book will achieve, 22 Summary, 23 References, 23 Further reading, 23 Web sites, 23 2 Analytical Techniques in Blood Science, 25 2.1 Venepuncture, 25 2.2 Anticoagulants, 26 2.3 Sample identification and tracking, 27 2.4 Technical and analytical confidence, 27 2.5 Major techniques, 32 2.6 Molecular genetics, 43 2.7 Point of care testing, 47 2.8 Health and safety in the laboratory, 48 Summary, 49 Further reading, 50 Web sites, 50 3 The Physiology of the Red Blood Cell, 51 3.1 Introduction, 51 3.2 The development of blood cells, 52 3.3 Erythropoiesis, 56 3.4 The red cell membrane, 58 3.5 The cytoplasm of the red cell, 60 3.6 Oxygen transport, 66 3.7 Recycling the red cell, 68 3.8 Red cell indices in the full blood count, 69 3.9 Morphology of the red cell, 72 Summary, 74 Further reading, 74 4 The Pathology of the Red Blood Cell, 75 4.1 Introduction: diseases of red cells, 75 4.2 Anaemia resulting from attack on, or stress to, the bone marrow, 78 4.3 Anaemia due to deficiency, 80 4.4 Intrinsic defects in the red cell, 85 4.5 External factors acting on healthy cells, 100 4.6 Erythrocytosis and polycythaemia, 103 4.7 Molecular genetics and red cell disease, 105 4.8 Inclusion bodies, 105 4.9 Case studies, 105 Summary, 107 References, 107 Further reading, 107 5 White Blood Cells in Health and Disease, 109 5.1 Introduction, 109 5.2 Leukopoiesis, 111 5.3 Neutrophils, 115 5.4 Lymphocytes, 116 5.5 Monocytes, 117 5.6 Eosinophils, 118 5.7 Basophils, 119 5.8 Leukocytes in action, 120 5.9 White cells in clinical medicine, 127 5.10 Case studies, 132 Summary, 132 Further reading, 133 6 White Blood Cell Malignancy 135 6.1 The genetic basis of leukocyte malignancy, 135 6.2 Tissue techniques in haemato-oncology, 139 6.3 Leukaemia, 141 6.4 Lymphoma, 149 6.5 Myeloma and related conditions, 152 6.6 Myelofibrosis and myelodysplasia, 157 6.7 Case studies, 157 Summary, 158 Further reading, 159 Guidelines, 159 7 The Physiology and Pathology of Haemostasis, 161 7.1 The blood vessel wall, 162 7.2 Platelets, 163 7.3 The coagulation pathway, 165 7.4 Haemostasis as the balance between thrombus formation and removal, 168 7.5 The haemostasis laboratory, 171 7.6 The pathology of thrombosis, 173 Summary, 175 Further reading, 175 8 The Diagnosis and Management of Disorders of Haemostasis, 177 8.1 Thrombosis 1: overactive platelets and thrombocytosis, 177 8.2 Thrombosis 2: overactive coagulation, 181 8.3 Haemorrhage 1: platelet underactivity and thrombocytopenia, 193 8.4 Haemorrhage 2: coagulation underactivity, 199 8.5 Disseminated intravascular coagulation, 203 8.6 Molecular genetics in haemostasis, 204 8.7 Case studies, 205 Summary, 206 References, 206 Further reading, 207 Guidelines, 207 Web sites, 207 9 Immunopathology, 209 9.1 Introduction, 209 9.2 Basics of the immune system, 210 9.3 Humoral immunity, 212 9.4 Immunopathology 1: immunodeficiency, 215 9.5 Immunopathology 2: hypersensitivity, 221 9.6 Immunopathology 3: autoimmune disease, 226 9.7 Immunotherapy, 232 9.8 The immunology laboratory, 234 9.9 Case studies, 238 Summary, 239 References, 240 Further reading, 240 Guidelines, 240 Web sites, 240 10 Immunogenetics and Histocompatibility, 241 10.1 The genetics of antigen recognition, 241 10.2 Human leukocyte antigens, 245 10.3 Transplantation, 251 10.4 Autoimmunity and human leukocyte antigens, 257 Summary, 260 Further reading, 260 Guidelines, 260 Web sites, 260 11 Blood Transfusion, 261 11.1 Blood collection and processing, 262 11.2 Blood groups, 265 11.3 Laboratory practice of blood transfusion, 273 11.4 Clinical practice of blood transfusion, 279 11.5 Hazards of blood transfusion, 281 Summary, 284 References, 284 Further reading, 284 Guidelines, 284 Web sites, 285 12 Waste Products, Electrolytes and Renal Disease, 287 12.1 Renal anatomy and physiology, 287 12.2 Homeostasis, 288 12.3 Excretion, 295 12.4 Renal endocrinology, 297 12.5 Renal disease, 298 12.6 Case studies, 301 Summary, 303 Further reading, 303 Guidelines, 303 Web sites, 303 13 Hydrogen Ions, pH, and Acid–Base Disorders, 305 13.1 Ions and molecules, 305 13.2 Blood gases, 308 13.3 Acidosis (pH <7.3), 312 13.4 Alkalosis (pH >7.5), 313 13.5 Mixed acid–base conditions, 314 13.6 Clinical interpretation, 314 13.7 Case studies, 315 Summary, 316 Further reading, 317 Web site, 317 14 Glucose, Lipids and Atherosclerosis, 319 14.1 Glucose, 319 14.2 Dyslipidaemia, 333 14.3 Atherosclerosis, 343 14.4 Case studies, 347 Summary, 348 Further reading, 348 Guidelines, 349 Web sites, 349 15 Calcium, Phosphate, Magnesium and Bone Disease, 351 15.1 Calcium, 352 15.2 Phosphates, 355 15.3 Magnesium, 355 15.4 The laboratory, 355 15.5 Disorders of calcium homeostasis, 357 15.6 Disorders of phosphate homeostasis, 360 15.7 Disorders of magnesium homeostasis, 362 15.8 Bone physiology, 363 15.9 Bone disease, 364 15.10 Case studies, 368 Summary, 369 Further reading, 370 Guidelines, 370 Web sites, 370 16 Nutrients and Gastrointestinal Disorders, 371 16.1 Nutrients, 371 16.2 The intestines, 375 16.3 Case studies, 381 Summary, 382 Further reading, 382 Guidelines, 382 17 Liver Function Tests and Plasma Proteins, 383 17.1 Anatomy and physiology of the liver, 384 17.2 Liver function tests, 389 17.3 Diseases of the liver, 390 17.4 Plasma proteins, 396 17.5 Case studies, 405 Summary, 406 Further reading, 406 Web sites, 406 18 Hormones and Endocrine Disorders, 407 18.1 Endocrine physiology, 407 18.2 The pathology of the endocrine system, 417 18.3 Case studies, 434 Summary, 435 Further reading, 435 Web sites, 436 19 Cancer and Tumour Markers, 437 19.1 General concepts in cancer biology, 437 19.2 Blood science and cancer, 440 19.3 Molecular genetics, 444 19.4 Case studies, 445 Summary, 446 Further reading, 446 Guidelines, 447 Web sites, 447 20 Inherited Metabolic Disorders, 449 20.1 The genetics of inheritance, 449 20.2 Molecular inherited metabolic disorders, 451 20.3 Organelle inherited metabolic disorders, 455 20.4 Antenatal diagnosis and neonatal screening, 455 20.5 Case studies, 456 Summary, 457 Further reading, 457 21 Drugs and Poisons, 459 21.1 Toxicology, 459 21.2 Toxicology of specific compounds, 461 21.3 Therapeutic drug monitoring, 465 21.4 Case studies, 468 Summary, 469 References, 469 Further reading, 469 22 Case Reports in Blood Science, 471 Abbreviations, 471 Case report 1, 472 Anaemia, hypercalcaemia, proteinuria, myeloma Case report 2, 473 Diabetes, glycated haemoglobin, chronic renal failure Case report 3, 474 Acute kidney injury, leucocytosis, neutrophilia, viruses Case report 4, 475 Part 1: Obesity, colorectal cancer, CEA, hypothyroidism. Part 2: Alcoholism, raised GGT and triacylglycerols Case report 5, 477 Part 1: No abnormalities. Part 2: Asthma, raised IgE. Part 3: Falling haemoglobin, rising ESR, lung cancer Case report 6, 479 Hypothyroidism, marginally reduced haemoglobin Case report 7, 480 Raised CRP, ESR, rheumatoid factor and anti-nuclear antibodies; borderline anti-dsDNA antibodies, low C3, low eGFR and so mild renal failure, systemic lupus erythematosus Case report 8, 481 Normal blood results in renal transplantation Case report 9, 482 Falling albumin, eGFR, haemoglobin, red cell count and platelets, rising ESR, white cell count and neutrophila, CRP, urea and creatinine, septicaemia Case report 10, 484 Microcytic anaemia, thrombocytopenia, lymphocytosis, abnormal LFTs, falling albumin, raised CRP, myositis with raised CK, viruses Case report 11, 486 Acidosis, hyperglycaemia, diabetic ketoacidosis, acute renal injury, raised urea and creatinine Case report 12, 487 Low haemoglobin, thrombocytopenia, raised CRP and d-dimers, abnormal LFTs, malaria, pregnancy Case report 13, 488 Raised aldosterone, hypernatraemia, hypokalaemia, Conn’s syndrome Case report 14, 489 Paediatric diabetic ketoacidosis, hyperglycaemia, low bicarbonate, raised phosphates, ALP and proteins References, 490 Appendix: Reference Ranges, 491 Further Reading, 493 Glossary, 495 Index, 519

Read more less

Book Synopsis* Integrated textbook combining three subjects, haematology, clinical biochemistry and immunology to provide a one-stop text on blood science, in line with the new IBMS and NHS training structure * Suitable for blood science courses opening in many universities at senior Undergraduate level (units) and Masters level.Table of ContentsPreface, xiii Acknowledgements, xv List of Abbreviations, xvii About the Companion Website, xxi 1 Introduction to Blood Science, 1 1.1 What is blood science?, 1 1.2 Biochemistry, 6 1.3 Blood transfusion, 8 1.4 Genetics, 10 1.5 Haematology, 14 1.6 Immunology, 17 1.7 The role of blood science in modern healthcare, 19 1.8 What this book will achieve, 22 Summary, 23 References, 23 Further reading, 23 Web sites, 23 2 Analytical Techniques in Blood Science, 25 2.1 Venepuncture, 25 2.2 Anticoagulants, 26 2.3 Sample identification and tracking, 27 2.4 Technical and analytical confidence, 27 2.5 Major techniques, 32 2.6 Molecular genetics, 43 2.7 Point of care testing, 47 2.8 Health and safety in the laboratory, 48 Summary, 49 Further reading, 50 Web sites, 50 3 The Physiology of the Red Blood Cell, 51 3.1 Introduction, 51 3.2 The development of blood cells, 52 3.3 Erythropoiesis, 56 3.4 The red cell membrane, 58 3.5 The cytoplasm of the red cell, 60 3.6 Oxygen transport, 66 3.7 Recycling the red cell, 68 3.8 Red cell indices in the full blood count, 69 3.9 Morphology of the red cell, 72 Summary, 74 Further reading, 74 4 The Pathology of the Red Blood Cell, 75 4.1 Introduction: diseases of red cells, 75 4.2 Anaemia resulting from attack on, or stress to, the bone marrow, 78 4.3 Anaemia due to deficiency, 80 4.4 Intrinsic defects in the red cell, 85 4.5 External factors acting on healthy cells, 100 4.6 Erythrocytosis and polycythaemia, 103 4.7 Molecular genetics and red cell disease, 105 4.8 Inclusion bodies, 105 4.9 Case studies, 105 Summary, 107 References, 107 Further reading, 107 5 White Blood Cells in Health and Disease, 109 5.1 Introduction, 109 5.2 Leukopoiesis, 111 5.3 Neutrophils, 115 5.4 Lymphocytes, 116 5.5 Monocytes, 117 5.6 Eosinophils, 118 5.7 Basophils, 119 5.8 Leukocytes in action, 120 5.9 White cells in clinical medicine, 127 5.10 Case studies, 132 Summary, 132 Further reading, 133 6 White Blood Cell Malignancy 135 6.1 The genetic basis of leukocyte malignancy, 135 6.2 Tissue techniques in haemato-oncology, 139 6.3 Leukaemia, 141 6.4 Lymphoma, 149 6.5 Myeloma and related conditions, 152 6.6 Myelofibrosis and myelodysplasia, 157 6.7 Case studies, 157 Summary, 158 Further reading, 159 Guidelines, 159 7 The Physiology and Pathology of Haemostasis, 161 7.1 The blood vessel wall, 162 7.2 Platelets, 163 7.3 The coagulation pathway, 165 7.4 Haemostasis as the balance between thrombus formation and removal, 168 7.5 The haemostasis laboratory, 171 7.6 The pathology of thrombosis, 173 Summary, 175 Further reading, 175 8 The Diagnosis and Management of Disorders of Haemostasis, 177 8.1 Thrombosis 1: overactive platelets and thrombocytosis, 177 8.2 Thrombosis 2: overactive coagulation, 181 8.3 Haemorrhage 1: platelet underactivity and thrombocytopenia, 193 8.4 Haemorrhage 2: coagulation underactivity, 199 8.5 Disseminated intravascular coagulation, 203 8.6 Molecular genetics in haemostasis, 204 8.7 Case studies, 205 Summary, 206 References, 206 Further reading, 207 Guidelines, 207 Web sites, 207 9 Immunopathology, 209 9.1 Introduction, 209 9.2 Basics of the immune system, 210 9.3 Humoral immunity, 212 9.4 Immunopathology 1: immunodeficiency, 215 9.5 Immunopathology 2: hypersensitivity, 221 9.6 Immunopathology 3: autoimmune disease, 226 9.7 Immunotherapy, 232 9.8 The immunology laboratory, 234 9.9 Case studies, 238 Summary, 239 References, 240 Further reading, 240 Guidelines, 240 Web sites, 240 10 Immunogenetics and Histocompatibility, 241 10.1 The genetics of antigen recognition, 241 10.2 Human leukocyte antigens, 245 10.3 Transplantation, 251 10.4 Autoimmunity and human leukocyte antigens, 257 Summary, 260 Further reading, 260 Guidelines, 260 Web sites, 260 11 Blood Transfusion, 261 11.1 Blood collection and processing, 262 11.2 Blood groups, 265 11.3 Laboratory practice of blood transfusion, 273 11.4 Clinical practice of blood transfusion, 279 11.5 Hazards of blood transfusion, 281 Summary, 284 References, 284 Further reading, 284 Guidelines, 284 Web sites, 285 12 Waste Products, Electrolytes and Renal Disease, 287 12.1 Renal anatomy and physiology, 287 12.2 Homeostasis, 288 12.3 Excretion, 295 12.4 Renal endocrinology, 297 12.5 Renal disease, 298 12.6 Case studies, 301 Summary, 303 Further reading, 303 Guidelines, 303 Web sites, 303 13 Hydrogen Ions, pH, and Acid–Base Disorders, 305 13.1 Ions and molecules, 305 13.2 Blood gases, 308 13.3 Acidosis (pH <7.3), 312 13.4 Alkalosis (pH >7.5), 313 13.5 Mixed acid–base conditions, 314 13.6 Clinical interpretation, 314 13.7 Case studies, 315 Summary, 316 Further reading, 317 Web site, 317 14 Glucose, Lipids and Atherosclerosis, 319 14.1 Glucose, 319 14.2 Dyslipidaemia, 333 14.3 Atherosclerosis, 343 14.4 Case studies, 347 Summary, 348 Further reading, 348 Guidelines, 349 Web sites, 349 15 Calcium, Phosphate, Magnesium and Bone Disease, 351 15.1 Calcium, 352 15.2 Phosphates, 355 15.3 Magnesium, 355 15.4 The laboratory, 355 15.5 Disorders of calcium homeostasis, 357 15.6 Disorders of phosphate homeostasis, 360 15.7 Disorders of magnesium homeostasis, 362 15.8 Bone physiology, 363 15.9 Bone disease, 364 15.10 Case studies, 368 Summary, 369 Further reading, 370 Guidelines, 370 Web sites, 370 16 Nutrients and Gastrointestinal Disorders, 371 16.1 Nutrients, 371 16.2 The intestines, 375 16.3 Case studies, 381 Summary, 382 Further reading, 382 Guidelines, 382 17 Liver Function Tests and Plasma Proteins, 383 17.1 Anatomy and physiology of the liver, 384 17.2 Liver function tests, 389 17.3 Diseases of the liver, 390 17.4 Plasma proteins, 396 17.5 Case studies, 405 Summary, 406 Further reading, 406 Web sites, 406 18 Hormones and Endocrine Disorders, 407 18.1 Endocrine physiology, 407 18.2 The pathology of the endocrine system, 417 18.3 Case studies, 434 Summary, 435 Further reading, 435 Web sites, 436 19 Cancer and Tumour Markers, 437 19.1 General concepts in cancer biology, 437 19.2 Blood science and cancer, 440 19.3 Molecular genetics, 444 19.4 Case studies, 445 Summary, 446 Further reading, 446 Guidelines, 447 Web sites, 447 20 Inherited Metabolic Disorders, 449 20.1 The genetics of inheritance, 449 20.2 Molecular inherited metabolic disorders, 451 20.3 Organelle inherited metabolic disorders, 455 20.4 Antenatal diagnosis and neonatal screening, 455 20.5 Case studies, 456 Summary, 457 Further reading, 457 21 Drugs and Poisons, 459 21.1 Toxicology, 459 21.2 Toxicology of specific compounds, 461 21.3 Therapeutic drug monitoring, 465 21.4 Case studies, 468 Summary, 469 References, 469 Further reading, 469 22 Case Reports in Blood Science, 471 Abbreviations, 471 Case report 1, 472 Anaemia, hypercalcaemia, proteinuria, myeloma Case report 2, 473 Diabetes, glycated haemoglobin, chronic renal failure Case report 3, 474 Acute kidney injury, leucocytosis, neutrophilia, viruses Case report 4, 475 Part 1: Obesity, colorectal cancer, CEA, hypothyroidism. Part 2: Alcoholism, raised GGT and triacylglycerols Case report 5, 477 Part 1: No abnormalities. Part 2: Asthma, raised IgE. Part 3: Falling haemoglobin, rising ESR, lung cancer Case report 6, 479 Hypothyroidism, marginally reduced haemoglobin Case report 7, 480 Raised CRP, ESR, rheumatoid factor and anti-nuclear antibodies; borderline anti-dsDNA antibodies, low C3, low eGFR and so mild renal failure, systemic lupus erythematosus Case report 8, 481 Normal blood results in renal transplantation Case report 9, 482 Falling albumin, eGFR, haemoglobin, red cell count and platelets, rising ESR, white cell count and neutrophila, CRP, urea and creatinine, septicaemia Case report 10, 484 Microcytic anaemia, thrombocytopenia, lymphocytosis, abnormal LFTs, falling albumin, raised CRP, myositis with raised CK, viruses Case report 11, 486 Acidosis, hyperglycaemia, diabetic ketoacidosis, acute renal injury, raised urea and creatinine Case report 12, 487 Low haemoglobin, thrombocytopenia, raised CRP and d-dimers, abnormal LFTs, malaria, pregnancy Case report 13, 488 Raised aldosterone, hypernatraemia, hypokalaemia, Conn’s syndrome Case report 14, 489 Paediatric diabetic ketoacidosis, hyperglycaemia, low bicarbonate, raised phosphates, ALP and proteins References, 490 Appendix: Reference Ranges, 491 Further Reading, 493 Glossary, 495 Index, 519

Read more less

Book SynopsisProviding the practicing and trainee hematologist with a practical and immediately applicable compendium of answers the Clinical Manual of Blood and Bone Marrow Transplantation covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program. Supplies the practicing and trainee hematologist with a practical and immediately applicable compendium of answers to clinical questionsCovers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant programContains concise chapters written with a focus on tables, algorithms and figures to aid rapid referralBenefits from expert contributions from an international authorshipTrade Review"... the book provides a concise practical expert review in a well-organized format of 42 chapters, each annotated with numerous practical headings to enhance focused learning. The expert authors of each chapter in the Clinical Manual of Blood and Bone Marrow Transplantation are part of that success story, and their up-to-date contributions to the field are elucidated in the clearest of terms in this worthy addition to the literature. This book is recommended for The ASCO Post readers, especially residents and fellows who are interested in pursuing a career in blood cancers" (The ASCO Post, September 2017)Table of ContentsContributors, ix Preface, xiv 1 Donor and graft selection strategy, 1Ayman Saad, Marisa B. Marques, and Shin Mineishi 2 HLA typing and implications, 9Bronwen E. Shaw and Stephen R. Spellman 3 Risk]benefit assessment in allogeneic hematopoietic transplant: Factors, scores, and models, 19Mahmoud Elsawy and Mohamed L. Sorror 4 Donor and recipient pre]transplant evaluation, 36Shuang Fu and Navneet S. Majhail 5 Autologous and allogeneic progenitor cell mobilization, 45Racquel D. Innis]Shelton and Luciano J. Costa 6 Hematopoietic stem and progenitor cell collection by apheresis: Techniques and tricks, 53Anand Padmanabhan 7 Hematopoietic cell processing: From procurement to infusion, 59Jay S. Raval, Kathryn McKay, and Yara A. Park 8 Graft manipulation: T-cell depletion and beyond, 66Christina Cho and Miguel]Angel Perales 9 Graft]versus]host disease prophylaxis, 73Melhem Solh and Asad Bashey 10 Acute lymphoblastic leukemia, 80Ghada Zakout and Adele K. Fielding 11 Acute myeloid leukemia, 89Hillard M. Lazarus and Masumi Ueda 12 Myelodysplastic syndromes, 97Melinda Biernacki and H. Joachim Deeg 13 Chronic myelogenous leukemia, 108Daniel Egan and Jerald Radich 14 Philadelphia chromosome negative myeloproliferative neoplasms, 116Nicolaus Kröger 15 Chronic lymphocytic leukemia, 123Fabienne McClanahan Lucas and John Gribben 16 Hodgkin Lymphoma, 131Anna Sureda and Eva Domingo]Domenech 17 Indolent lymphomas, 140Narendranath Epperla, Hamza Hashmi, and Mehdi Hamadani 18 Diffuse large B-cell lymphoma, 151Syed Abbas Ali, Istvan Redei, and Syed A. Abutalib 19 Mantle cell lymphoma, 164Narendranath Epperla and Timothy S. Fenske 20 T-cell lymphoma, 179Adrienne A. Phillips and Koen van Besien 21 Primary CNS lymphoma, 188Henry C. Fung, Philip Pancari, and Patricia Kropf 22 Autologous hematopoietic transplant in multiple myeloma, 194Nisha S. Joseph, Ajay K. Nooka, and Sagar Lonial 23 Allogeneic hematopoietic transplant in multiple myeloma, 207Parameswaran Hari and Binod Dhakal 24 Light]chain amyloidosis, 214Amara S. Hussain and Anita D’Souza 25 Autoimmune disorders, 221Adam Bryant and Harold Atkins 26 Testicular cancer, 229Moshe C. Ornstein, Navneet S. Majhail, and Timothy Gilligan 27 Sickle cell disease, 236Sonali Chaudhury and Shalini Shenoy 28 Hematopoietic cell transplant in thalassemia, 246Emanuele Angelucci and Federica Pilo 29 Fanconi anemia, 255Flore Sicre de Fontbrune, Jean Soulier, and Regis Peffault de Latour 30 Immunodeficiency disorders, 264Jennifer A. Kanakry and Dennis D. Hickstein 31 Inherited metabolic disorders, 272Jaap Jan Boelens and Robert F. Wynn 32 Aplastic anemia and paroxysmal nocturnal hemoglobinuria, 281Andrew C. Dietz and Michael A. Pulsipher 33 HIV infection and transplantation, 290Nitya Nathwani, Stephen J. Forman, and Amrita Krishnan 34 Engraftment and graft failure: Assessment and practical considerations, 297Yogesh Jethava, Madan Jagasia, Mohamed Mohty, and Bipin N. Savani 35 Immune reconstitution and tolerance, 304udovic Belle and William R. Drobyski 36 Donor lymphocyte infusion, 315David C. Halverson and Daniel Fowler 37 Diagnosis and treatment of acute graft]versus]host disease, 324Natasha Kekre and Vincent T. Ho 38 Diagnosis and treatment of chronic graft]versus]host disease, 334Sabarinath Venniyil Radhakrishnan and Daniel R. Couriel 39 Prevention and treatment of infection, 348Corrado Girmenia, Gian Maria Rossolini, and Claudio Viscoli 40 Early non]infectious complications after hematopoietic cell transplantation, 359Piyanuch Kongtim and Stefan O. Ciurea 41 Post]transplant lymphoproliferative disorders, 369Michael D. Keller, Conrad R. Cruz, and Catherine M. Bollard 42 Survivorship issues after transplantation, 376Vanessa E. Kennedy, Madan Jagasia, and Bipin N. Savani Index, 384

Read more less

Book SynopsisThe third edition of this popular pocket book, A Beginner's Guide to Blood Cells written by Professor Barbara Bain, provides a concise introduction to normal and abnormal blood cells and blood counts for trainees in haematology. Includes a brand new chapter on emergency morphology, designed to make the clinical significance and urgency of certain laboratory findings clear for biomedical scientists and to assist trainee haematologists in the recognition of major clinically important abnormalities Contains exceptional full colour images throughout Introduces important basic concepts of hematology, setting haematological findings in a clinical context Provides a fully updated self-assessment section An essential resource for trainee haematologists, biomedical scientists, and biomedical science and medical students Table of ContentsPreface vii Abbreviations viii 1 The Blood Film and Count 1 Blood 1 The blood film 1 The blood count 17 Normal ranges 20 How to examine a blood film 22 2 Assessing Red Cells 29 Assessing red cell number and distribution (anaemia polycythaemia rouleaux formation red cell agglutination) 29 Assessing red cell size (microcytosis macrocytosis anisocytosis) 32 Assessing red cell shape (poikilocytosis) 32 Assessing red cell colour (hypochromia hyperchromia anisochromasia polychromasia) 32 Detecting red cell inclusions (Pappenheimer bodies basophilic stippling Howell–Jolly bodies) 41 The full blood count in red cell assessment 43 3 Assessing White Cells and Platelets 45 Assessing white cell and platelet numbers 45 Assessing neutrophil morphology 46 Assessing lymphocyte morphology 51 Assessing morphology of monocytes eosinophils and basophils 53 Assessing platelet morphology 53 4 Haematological Findings in Health and Disease 55 The blood film and count in healthy individuals 55 Abnormalities of red cells 56 Abnormalities of white cells 77 5 Emergency Morphology: The Relevance of the Full Blood Count and Blood Film in Acute Illness 97 Thrombocytopenia 97 Thrombotic microangiopathy and microangiopathic haemolytic anaemia 98 Other acute anaemia 100 Kidney injury and disease 105 Acute hepatic damage and liver failure 107 Acute leukaemia 109 Bacterial infection and other causes of leucocytosis 109 Eosinophilia 113 Lymphocytosis 115 Malaria 116 Neutropenia 119 Pancytopenia and leucoerythroblastic blood films 121 Neonatal emergencies 122 6 Self]assessment 125 Index 143

Read more less

Book SynopsisMeeting the needs of patients while minimizing blood transfusions requires special expertise, precise monitoring and innovative techniques. This cutting-edge resource covers all the important clinical aspects of transfusion medicine in diverse clinical settings, with a special emphasis on alternatives to transfusion. Edited by a multidisciplinary team consisting of a transfusion specialist, an anesthesiologist and an intensive care specialist this book is endorsed by the Network for Advancement of Transfusion Alternatives. The contributors review the appropriate use of fluids and of blood products, and describe the latest treatment options available to decrease the need for allogeneic blood products including: Argon beam Cell saver Harmonic scalpel Normovolemic haemodilution Synthetic erythropoietin Antifibrinolytics Recombinant factor VIIa Advanced monitoring of hemostasis Intravenous iron Trade Review"It would be of great interest to students or practitioners in laboratory and/or transfusion medicine, anesthesiology, and surgery interested in alternatives to blood transfusion. The editors and authors are credible authorities in their fields." (Doody's, 9 September 2011) "The book provides the state of the art in blood transfusion management and I shall certainly be referring to it often as I continue to develop a blood conservation programme in my own hospital." (The Bulletin of the Royal College of Pathologists, 1 July 2011) Table of ContentsContributors List ix Part 1 History and Development of Transfusion Medicine 1 1 From Blood Transfusion to Transfusion Medicine 3Alice Maniatis Part 2 Allogeneic Blood Usage—Risks and Benefits 9 2 Allogeneic Blood Components 11Rebecca Cardigan & Sheila MacLennan 3 Current Information on the Infectious Risks of Allogeneic Blood Transfusion 21Alan D. Kitchen & John A. J. Barbara 4 Immunological Complications of Blood Transfusion 31Clare Taylor Cristina Navarrete & Marcela Contreras 5 Immunomodulation and Allogeneic Blood Transfusion 47Marloes Waanders Leo Van De Watering & Anneke Brand 6 Pathogen Inactivation of Blood Components 60Chris Prowse 7 The Benefits of Allogeneic Erythrocyte Transfusion: What Evidence Do We Have? 68Neil Soni & Benjamin Thomas Part 3 Volume Replacement 83 Section 1 Plasma and Albumin 85 8 Plasma and Albumin 87Philippe L. Baele Section 2 Crystalloids and Synthetic Colloids 109 9 Pharmacology of Intravenous Fluids 111Michael F.M. James 10 Crystalloids versus Colloids: The Controversy 119Hengo Haljamäe 11 Effects of Synthetic Colloids on Hemostasis 137Sibylle A. Kozek-Langenecker & Gisela Scharbert 12 Hydroxyethyl Starch and Renal Dysfunction 150Laurent Jacob Nicholas Heming & Bertrand Guidet 13 Choice of a Synthetic Colloid for Surgery 158Joachim Boldt 14 Choice of Colloid for Intensive Care Patients 168Yasser Sakr & Yalcin Inel 15 Hypertonic Saline Solutions for the Initial Treatment of Patients with Traumatic Injuries 179Charles E. Wade & Michael A. Dubick 16 Hyperchloremic Acidosis 194Edward Burdett & Andre Vercueil Part 4 Tolerance of Anemia 203 17 Basic Principles of Oxygen Transport and Calculations 205Jean-Louis Vincent Pongdhep Theerawit & Davide Simion 18 Assessment of Tissue Oxygenation 210Michael Piagnerelli Ann Dierick & Philippe Van der Linden 19 Tissue Oxygenation and Blood Transfusion 218Stefan Suttner & Joachim Boldt 20 Anemia and Cardiovascular Disease 229Antonis S. Manolis Spyridon Koulouris Kostas Triantafyllou Dimitris Sakellariou Sokratis Pastromas & Helen Melita Part 5 Perioperative Hemostasis 253 21 Monitoring of Hemostasis in the Perioperative Setting 255Sibylle A. Kozek-Langenecker & Eva Schaden 22 Antifibrinolytics in Open-Heart Surgery 267Wulf Dietrich 23 Efficacy and Safety of Recombinant Activated Factor VII to Control Bleeding in Nonhemophiliac Patients 278Jean-François Hardy Sylvain Bélisle & Philippe Van der Linden Part 6 Transfusion Triggers 293 24 Role of Hemoglobin/Hematocrit 295Kristine J. Guleserian Hae W. Kim Bruce Pearce Arkadiy Pitman & A. Gerson Greenburg 25 Calculation of Blood Loss 303Mark E. Brecher 26 Management of Massive Transfusion 313Jean-François Hardy & Marc Samama Part 7 Alternatives to Allogeneic Blood Transfusion 329 Section 1 Pharmaceutical Approaches 331 27 Iron Deficiency: Causes Diagnosis and Management 335Manuel Muñoz José Antonio García-Erce & Elvira Bisbe 28 Current Status of Perisurgical Erythropoietin Therapy 350Lawrence T. Goodnough 29 Erythropoietin and Iron Therapy in Patients with Renal Failure 357Lucia Del Vecchio & Francesco Locatelli 30 Hemoglobin-based Blood Substitutes 368G. Deby-Dupont Bernadette Remy & Maurice Lamy 31 Perfluorocarbon Emulsions 380Pedro Cabrales Section 2 Surgical Techniques 389 32 Minimally Invasive Cardiac Surgery: Impact on Blood Loss and Transfusion 391He Tao & Fraser Rubens 33 Adjunctive Strategies to Impact Blood Transfusion in Cardiac Surgery 408L. Ressler & Fraser Rubens Section 3 Anesthetic Techniques 419 34 Anesthetic Techniques to Reduce Blood Loss 421Dafydd Thomas 35 Controlled Hypotension Decreases Blood Transfusion Requirement: Fact or Fallacy? 430Richard P. Dutton 36 Acute Normovolemic Hemodilution 439Javad Bidgoli & Philippe Van der Linden 37 Hyperoxic Hemodilution 450Jens Meier Konrad Messmer & Oliver Habler 38 Intraoperative and Postoperative Cell Salvage 458Ernil Hansen & Hans Gombotz Section 4 Special Settings 475 39 Anemia and Red Blood Transfusion in Critical Care 477Tim Walsh 40 Red Blood Cell Transfusions and Alternatives to Treat the Anemia of Prematurity 490Ronald G. Strauss 41 Transfusion Alternatives in Orthopedic Surgery 498Manuel Muñoz José Antonio García-Erce & Jorge Cuenca 42 Transfusion Alternatives in Obstetrics 509Christian Breymann Part 8 Legal and Ethical Issues in Transfusion Medicine 521 43 Ethical Aspects of Informed Consent: American Models 523Ronald E. Domen 44 Blood Transfusions Jehovah’s Witnesses and the American Patients’ Rights Movement 531Charles H. Baron Part 9 Cost Issues 557 45 The Cost and Cost-Effectiveness of Allogeneic and Autologous Blood 559Brian Custer 46 Autologous Blood Predonation in Cardiac Surgery 569Wulf Dietrich 47 Cost-Effectiveness of Pharmacological Alternatives 575Dean Fergusson & Brian Hutton Index 581

Read more less

Book SynopsisHaematology Nursing is a comprehensive handbook, with a nursing focus, on the care and management of patients with haematological disorders. Divided into four sections, the first provides an introduction to haematology, looking at haemopoiesis, immunology and genetics.Table of ContentsContributors vii Foreword x Section 1 Introduction to Haematology 1 1 Understanding Haemopoiesis 3 Marvelle Brown 2 Immunology 22 Jane Richardson and Tracey Cutler 3 Genes and Haematology 37 Gwyneth Morgan 4 The Cell 50 Louise Knight Section 2 Non-Malignant Haematology 61 Anaemia 5 Aplastic Anaemia: Pathophysiology, Care and Management 63 Audrey Yandle 6 Nutritional Anaemia: Pathophysiology, Care and Management 79 Marvelle Brown 7 Acquired Haemolytic Anaemia: Pathophysiology, Care and Management 96 Marvelle Brown 8 Inherited Haemolytic Anaemia: Pathophysiology, Care and Management 107 Marvelle Brown Haemoglobinopathies 9 Sickle Cell Disease and Thalassaemia: Pathophysiology, Care and Management 117 Marvelle Brown Haemochromatosis 10 Haemochromatosis: Pathophysiology, Care and Management 150 Jan Green Section 3 Myeloproliferative and Lymphoproliferative Disorders 163 11 Polycythaemia: Pathophysiology, Care and Management 165 Marvelle Brown 12 The Myelodysplastic Syndromes: Pathophysiology, Care and Management 171 Jackie Green 13 Acute Leukaemia: Pathophysiology, Care and Management 183 Jackie Green 14 Chronic Leukaemia: Pathophysiology, Care and Management 195 Samantha Toland 15 Multiple Myeloma: Pathophysiology, Care and Management 202 Marvelle Brown 16 Lymphoma: Pathophysiology, Care and Management 217 Tracey Cutler Section 4 Nursing Care Interventions 233 17 Blood Transfusion 235 Jan Green 18 Venous Access Devices 261 Janice Gabriel 19 Chemotherapy and Monoclonal Antibodies 275 Alison Simons and Tracey Cutler 20 Haemopoietic Stem Cell Transplant 287 Tracey Cutler 21 Palliative Care in Haematology 300 Dion Smyth Glossary of Terms 314 Index 317

Read more less

Book SynopsisA comprehensive, down-to-earth guide for anyone diagnosed with breast cancer. Being diagnosed with breast cancer can be scary and confusing. There are medical terms to learn, options to consider, and important decisions to make, all while trying to carry on with work, family, and life. The Breast Cancer Book can't reverse a diagnosis or make breast cancer disappear, but every page can inform and empower you or your loved ones, no matter where you are in the breast cancer experience. Written by three trusted expertsan oncologist, a breast surgeon, and a two-time breast cancer survivorthis multidisciplinary book walks you through everything you need to know about breast cancer so that you can make the best decisions about diagnosis, treatment, and follow-up care. In plain, easy-to-understand language that illuminates all the facets of this disease, the authors draw on their professional experience and the most current scientific knowledge to describe the risk factors for breast cancer;Trade ReviewThis book is written thoughtfully and empathetically and I would urge you to read it if you've received this frightening diagnosis.—Dr. Kathleen Thompson, author of From Both Ends of the Stethoscope:Getting through breast cancer – by a doctor who knows, Frost MagazineTable of ContentsList of TablesIntroduction A Message of HopePart One. Understanding Breast Cancer1. What Is Cancer?2. Breast Cancer Basics3. Demystifying Breast Cancer Risk4. Strategies to Reduce Your Risk of Developing Breast Cancer5. Hereditary Breast CancerPart Two. Finding Breast Cancer and Dealing with a Diagnosis6. Screening Tools and Technologies7. Making a Diagnosis8. After a Diagnosis: Charting a Course and Assembling Your TeamPart Three. Understanding Treatment Choices and Making Decisions9. Local Therapy: Breast Cancer Surgery10. Radiation Therapy11. Rebuilding Your Breasts after Mastectomy12. Treating Noninvasive Breast Cancer: Ductal Carcinoma In Situ13. Reducing the Risk of Recurrence: Systemic Therapies for Invasive Breast Cancer14. Cancer Again: Treating Local or Regional Recurrence15. Treating Metastatic Breast Cancer16. Considering Breast Cancer Clinical Trials17. Treating Less Common Types of Breast Cancers and Male Breast CancerPart Four. Finding Answers18. Managing Breast Cancer Treatment Side Effects19. Complementary, Integrative, and Alternative Medicine20. Meeting the Emotional Challenges of Breast Cancer21. Family Matters during and after Breast Cancer22. Insurance and Money Matters during Breast Cancer TreatmentPart Five. Moving On23. Supportive Care and Symptom Management for Women with Metastatic Breast Cancer24. Living Well beyond Cancer: Healthy Breast Cancer SurvivorshipResourcesGlossaryIndex

Read more less

Book SynopsisA comprehensive, down-to-earth guide for anyone diagnosed with breast cancer. Being diagnosed with breast cancer can be scary and confusing. There are medical terms to learn, options to consider, and important decisions to make, all while trying to carry on with work, family, and life. The Breast Cancer Book can't reverse a diagnosis or make breast cancer disappear, but every page can inform and empower you or your loved ones, no matter where you are in the breast cancer experience. Written by three trusted expertsan oncologist, a breast surgeon, and a two-time breast cancer survivorthis multidisciplinary book walks you through everything you need to know about breast cancer so that you can make the best decisions about diagnosis, treatment, and follow-up care. In plain, easy-to-understand language that illuminates all the facets of this disease, the authors draw on their professional experience and the most current scientific knowledge to describe the risk factors for breast cancer;Trade ReviewThis book is written thoughtfully and empathetically and I would urge you to read it if you've received this frightening diagnosis.—Dr. Kathleen Thompson, author of From Both Ends of the Stethoscope:Getting through breast cancer – by a doctor who knows, Frost MagazineTable of ContentsList of TablesIntroduction A Message of HopePart One. Understanding Breast Cancer1. What Is Cancer?2. Breast Cancer Basics3. Demystifying Breast Cancer Risk4. Strategies to Reduce Your Risk of Developing Breast Cancer5. Hereditary Breast CancerPart Two. Finding Breast Cancer and Dealing with a Diagnosis6. Screening Tools and Technologies7. Making a Diagnosis8. After a Diagnosis: Charting a Course and Assembling Your TeamPart Three. Understanding Treatment Choices and Making Decisions9. Local Therapy: Breast Cancer Surgery10. Radiation Therapy11. Rebuilding Your Breasts after Mastectomy12. Treating Noninvasive Breast Cancer: Ductal Carcinoma In Situ13. Reducing the Risk of Recurrence: Systemic Therapies for Invasive Breast Cancer14. Cancer Again: Treating Local or Regional Recurrence15. Treating Metastatic Breast Cancer16. Considering Breast Cancer Clinical Trials17. Treating Less Common Types of Breast Cancers and Male Breast CancerPart Four. Finding Answers18. Managing Breast Cancer Treatment Side Effects19. Complementary, Integrative, and Alternative Medicine20. Meeting the Emotional Challenges of Breast Cancer21. Family Matters during and after Breast Cancer22. Insurance and Money Matters during Breast Cancer TreatmentPart Five. Moving On23. Supportive Care and Symptom Management for Women with Metastatic Breast Cancer24. Living Well beyond Cancer: Healthy Breast Cancer SurvivorshipResourcesGlossaryIndex

Read more less

Book SynopsisThe most comprehensive guide available on hereditary cancers, from understanding risk, prevention, and genetic counseling and testing to treatment, quality of life, and more. Up to 10 percent of cancers are caused by inherited mutations in specific genes. Finding out that you or your loved ones may be at increased risk of developing cancer because of a genetic mutation raises a lot of questions: Is cancer inevitable? Is there anything I should do differently in my life? Will my children also be at higher risk of cancer? Should I have preemptive treatments or surgery? This comprehensive guide provides answers to these questions and more. Written by three passionate patient advocates, this book is a compilation of the trusted information and support provided for more than two decades by Facing Our Risk of Cancer Empowered (FORCE), the de facto voice of the hereditary cancer community. Combining the latest scientific research with national guidelines, expert advice, and compelling patieTable of ContentsList of TablesForeword, by Matthew Boland Yurgelun, MDIntroductionPart I. Understanding Cancer and Inherited Risk1. The Link between Genetics and CancerThe Basics of GeneticsGene Wear and Tear and Repair How Cancers Develop and Grow Most Cancers Aren't Caused by Inherited Mutations2. What's Swimming in Your Gene Pool?Hidden Risk in the Family TreePlotting Your Genetic Pedigree3. Signs of Hereditary CancerThe Value of Genetic Counseling Making Decisions about Testing Insurance CoveragePrivacy and Protection4. What Your Test Results Tell YouPositive, Negative, Maybe Making Sense of StatisticsYou Have a Mutation; Now What?Part II. Inherited Gene Mutations and the Cancers They Cause5. Introducing BRCA1 and BRCA2Who Inherits a BRCA Mutation?Signs of a BRCA MutationLevels of Risk6. Lynch Syndrome: Five Genes, One Hereditary SyndromeSigns of Lynch Syndrome in FamiliesLevels of Risk7. Other Genes That Are Linked to Inherited Cancer RiskLess Known, Less Studied Genes8. Breast Cancer BasicsSigns and SymptomsWhat Affects Breast Cancer Risk?Types of Breast Cancer9. Gynecologic CancersOvarian, Fallopian Tube, and Primary Peritoneal CancersEndometrial Cancers10. Gastrointestinal CancersColorectal CancerSmall Bowel CancerPancreatic CancerStomach CancerAnal Cancer11. Genitourinary CancersProstate CancerBladder, Ureter, and Renal Pelvis Cancers12. MelanomaMelanoma of the SkinOcular MelanomaPart III. Strategies for Risk Reduction and Early Detection13. Risk Management GuidelinesGuidelines for BRCA1 or BRCA2 Gene MutationsGuidelines for Lynch Syndrome Gene MutationsGuidelines for Mutations in Other Genes14. Early Detection Strategies for High-Risk PeopleThe Vocabulary of ScreeningSurveillance for Breast CancerSurveillance for Gynecologic CancersSurveillance for Gastrointestinal CancersSurveillance for Prostate and Other Genitourinary Cancers Surveillance for MelanomaScreening for Other Hereditary Cancers15. Medications That Reduce Cancer RiskRisk-Reducing Medications for Breast CancerRisk-Reducing Medications for Gynecologic CancersRisk-Reducing Medications for Colorectal Cancers16. Surgeries That Reduce Breast Cancer RiskMastectomy ProceduresBreast Reconstruction ChoicesSide Effects, Risks, and Recovery17. Surgeries That Reduce the Risk of Gynecologic CancersSalpingo-Oophorectomy to Reduce the Risk of Ovarian CancerHysterectomy to Reduce the Risk of Endometrial Cancer18. Surgeries That Reduce the Risk of Gastrointestinal CancersTotal and Segmental Colectomy to Reduce the Risk of Colon CancerTotal Gastrectomy to Reduce the Risk of Stomach Cancer19. Factors That Affect Cancer RiskNutrition, Weight, and Physical Activity Alcohol: An Unwise ChoiceSmoking and Tobacco ProductsOther Lifestyle and Behavioral Risk FactorsPart IV. Treatment Choices for Hereditary Cancers20. Identifying Tumor Characteristics That Inform Treatment ChoicesStaging and Grading CancerTargeted Approaches to TreatmentDNA Damage Repair Genes21. Treating Breast CancerCancer Type, Subtype, and StageBiomarker TestingGenetic TestingOptions for TreatmentFollow-Up Care22. Treating Gynecologic CancersOptions for Ovarian, Fallopian Tube, and Primary Peritoneal CancersOptions for Endometrial Cancer23. Treating Gastrointestinal CancersOptions for Colorectal CancerOptions for Pancreatic CancerOptions for Gastric Cancer24. Treating Genitourinary CancersOptions for Prostate CancerOptions for Bladder, Renal Pelvis, and Ureter Cancers25. Treating Melanoma Options for Melanoma in the SkinOptions for Ocular MelanomaPart V. Living with Inherited High Risk26. Regaining Sexual Health and IntimacyBody ImageCoping with PainReduced Sexual DesireErectile DysfunctionRebuilding Intimacy27. Effects of Prevention and Treatment on FertilityPreserving Fertility in WomenPreserving Fertility in MenOther Parenting Alternatives28. Managing MenopauseSymptoms of Early MenopauseReplacement HormonesLong-Term Side Effects29. Side Effects and Other Quality-of-Life IssuesSummarizing Side Effects by TreatmentManaging Immediate Side EffectsLong-Term Effects of Prevention and TreatmentPrevivorship, Survivorship, and Follow-Up CareEnd-of-Life Issues30. Making Difficult Decisions Start at the Beginning: Should You Be Tested?Decisions about Your Cancer RiskDecisions about TreatmentPrevention and Treatment Clinical TrialsDecision-Making in 15 Steps31. You Are Not AloneCreate a Support SystemFind Emotional StrengthPursue Financial ResourcesLook to the HorizonAcknowledgmentsGlossaryNotesResourcesIndex

Read more less

Book SynopsisHuman Blood Groups is a comprehensive and fully referenced text covering both the scientific and clinical aspects of red cell surface antigens, including: serology, inheritance, biochemistry, molecular genetics, biological functions and clinical significance in transfusion medicine. Since the last edition, seven new blood group systems and over 60 new blood group antigens have been identified. All of the genes representing those systems have now been cloned and sequenced. This essential new information has made the launch of a third edition of Human Blood Groups, now in four colour, particularly timely. This book continues to be an essential reference source for all those who require clinical information on blood groups and antibodies in transfusion medicine and blood banking.Trade Review “It is fascinatingly detailed, and makes a wonderful book for browsing, with many interesting facts, often with historical context to each blood group discovery; but its main audience will be those working within the transfusion laboratory, for whom this will be an invaluable reference.” (Haem Trainee, 1 August 2013) “Get it. If you are involved in blood banking, this is a must-have.” (Doody’s, 14 June 2013)Table of ContentsForeword, vii Preface to the third edition, viii Some abbreviations used, ix 1 Human blood groups: introduction, 1 2 ABO, H, and Lewis systems, 11 3 MNS blood group system, 96 4 P1PK, Globoside, and FORS blood group systems, plus some other related blood groups, 162 5 Rh and RHAG blood group systems, 182 6 Lutheran blood group system, 259 7 Kell and Kx blood group systems, 278 8 Duffy blood group system, 306 9 Kidd blood group system, 325 10 Diego blood group system, 336 11 Yt blood group system, 354 12 Xg blood group system, 359 13 Scianna blood group system, 371 14 Dombrock blood group system, 376 15 Colton blood group system, 384 16 LW blood group system, 391 17 Chido/Rodgers blood group system, 400 18 Gerbich blood group system, 410 19 Cromer blood group system, 427 20 Knops blood group system and the Cost antigens, 439 21 Indian blood group system and the AnWj antigen, 449 22 Ok blood group system, 457 23 Raph blood group system, 461 24 JMH blood group system, 465 25 I and i antigens, and cold agglutination, 469 26 Gill blood group system, 485 27 Junior and Langereis blood group systems, 487 28 Er antigens, 493 29 Low frequency antigens, 495 30 High frequency antigens, including Vel, 500 31 Sid antigen, 505 32 HLA (Human Leucocyte-Associated) Class I antigens on red cells, 512 33 Polyagglutination and cryptantigens, 515 Index, 524

Read more less

Book SynopsisInflammatory Diseases of Blood Vessels< Inflammatory Diseases of Blood Vessels Second Edition Inflammatory Diseases of Blood Vessels provides a comprehensive overview of the science and clinical consequences of vascular inflammation in health and disease. In recent years, considerable progress has been made in understanding different forms of vasculitis. Investigation of pathogenesis of vascular inflammation has led to improved treatments and outcomes. Surgical and transplant procedures have improved in parallel with medical therapies. These areas are extensively examined in this new edition. Inflammatory Diseases of Blood Vessels is an excellent resource for a broad readership, including clinicians, investigators and their support teams in numerous specialties e.g. rheumatology, immunology, cardiology, cardiovascular surgery, pulmonary medicine, nephrology, pathology, vascular biology, embryology and imaging.Trade Review“This book provides a comprehensive overview of the science and clinical consequences of vascular inflammation in health and disease.” (European Journal of Immunology, 1 December 2012) “Overall, this is an excellent source of information on vasculitis for physicians at any level, including practicing rheumatologists.” (Doody’s, 2 November 2012) Table of ContentsList of Contributors Preface Section I. Biology of Blood Vessels and Mechanisms of Vascular Inflammation 1 Vascular Development Domenico Ribatti and Enrico Crivellato 2 Vascular Repair Christian Troidl, Kerstin Troidl, Georg Jung, Thomas Schmitz-Rixen and Wolfgang Schaper 3 Leukocyte Trafficking Braedon McDonald and Paul Kubes 4 Dendritic Cells and Vascular Inflammation Cornelia M. Weyand 5 T Cells and Vascular Inflammation Jörg J. Goronzy 6 Autoantibodies and Vascular Inflammation A.Rutgers, J.S.F. Sanders, J.W. Cohen Tervaert, C.G.M. Kallenberg 7 Neutrophils and Vascular Inflammation Matthew David Morgan and Caroline OS Savage 8 Cytokines and Vascular Inflammation Maria C Cid, Marc Corbera-Bellalta, Ester Planas-Rigol, Ester Lozano, Georgina Espígol-Frigolé, Ana García-Martínez, José Hernández-Rodríguez, Marta Segarra 9 Oxidative Stress and Vascular Inflammation David G. Harrison 10 Hemostasis and Vascular Inflammation Lawrence Leung and John Morser 11 Animal Models of Vasculitis Masato Nose 12 Arteries, Smooth Muscle Cells, and Genetic Causes of Thoracic Aortic Aneurysms Amy J. Reid and Dianna M. Milewicz 13 Innate Immunity in Atherosclerosis Shuang Chen, Prediman K. Shah and Moshe Arditi 14 Adaptive Immunity in Atherosclerosis Jan Nilsson Section II. Primary Autoimmune Vascular Diseases 15 Historical Perspectives Vasculitis Eric L. Matteson 16 Approach to the Differential Diagnosis of Vasculitis Eamonn S. Molloy and Carol A. Langford 17 Imaging of medium and large vessels (CT/PET/MR) Thorsten Alexander Bley 18 Kawasaki disease Rae S.M. Yeung 19 Henoch-Schonlein Purpura Philip J. Hashkes and Alexandra Villa-Forte 20 Polyarteritis Nodosa Eli M. Miloslavsky and John H. Stone 21 Microscopic polyangiitis Coen Stegeman 22 Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Gary S. Hoffman, Carol A. Langford and Ulrich Specks 23 Churg–Strauss Syndrome (Eosinophilic Granulomatosis with Polyangiitis, EGPA) Christian Pagnoux and Loïc Guillevin 24 Giant cell arteritis Cornelia M. Weyand and Jörg J. Goronzy 25 Takayasu's arteritis Kathleen Maksimowicz-McKinnon and Gary S. Hoffman 26 Behçet's Syndrome Yusuf Yazici, Ismail Simsek and Hasan Yazici 27 Cogan's Syndrome Rex M. McCallum and E. William St. Clair 28 Idiopathic cryoglobulinemic vasculitides Benjamin Terrier and Patrice Cacoub 29 Primary central nervous system vasculitis Rula A. Hajj-Ali and Leonard H. Calabrese 30 Single organ vasculitis José Hernández-Rodríguez and Gary S. Hoffman 31 Primary cutaneous vasculitis Jeffrey P. Callen 32 Buerger's disease (thromboangiitis obliterans) Ahmet Ruchan Akar and M. Serkan Durdu Section III. Secondary Causes of Vasculitis 33 Virus-associated vasculitides Dimitrios Vassilopoulos and Leonard H. Calabrese 34 Drug-induced vasculitis Peter A. Merkel 35 Rheumatoid vasculitis Kimberly P. Liang, Carl Turesson, Larry W. Moreland 36 Vasculopathy/Vasculitis and progressive systemic sclerosis Nezam Altorok, Omar R. Kahaly and Bashar Kahaleh 37 Vasculitis and Sjögren's syndrome George E. Fragoulis and Haralampos M. Moutsopoulos 38 Vasculitis in systemic lupus erythematosus Ricardo Garcia and Andras Perl 39 Vasculitis in the Idiopathic Inflammatory Myopathies Frederick W. Miller and Chester V. Oddis 40 Vasculitis and relapsing polychondritis Tanaz A. Kermani and Kenneth J. Warrington 41 Systemic Vasculitis in Sarcoidosis Alexandra Villa-Forte and Gary S. Hoffman 42 Vasculitis as a Paraneoplastic Syndrome and Direct Tumour Invasion of Vessels Claire E. Barber and Simon Carette Section IV. Recognizing Risks and Treating Damage from Vasculitis 43 Cholesterol and Modifications of Cholesterol in Rheumatic Disorders Jan Willem Cohen Tervaert 44 Prevention and treatment of medical complications Atul Khasnis and Carol A. Langford 45 Ophthalmic Risks and Complications Aassociated with the Treatment of Systemic Vasculitis Steven Yeh and James T. Rosenbaum 46 Subglottic Stenosis of Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Rahul Seth and Daniel S. Alam 47 Sino-Nasal Manifestations of Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Daniel S. Alam, Rahul Seth, Raj Sindwani 48 Neurologic Damage of Vasculitis C. David Lin 49 Endstage Renal Disease and Vasculitis Kirsten de Groot and Charles Pusey 50 Cardiothoracic Surgery for Takayasu's Arteritis and Giant Cell Arteritis Turki Albacker and Lars Svensson 51 Peripheral Vascular Surgery for Takayasu's Arteritis and Giant Cell Arteritis Ravi R. Rajani and Vikram S. Kashyap Index

Read more less

Book SynopsisDefined as red blood cell break down and the release of hemoglobin and intracellular contents into the plasma, hemolysis can seriously impact patient care as well as the laboratory's reputation through its affect on test results. Therefore, the European Preanalytical Scientific Committee, in collaboration with the International Federation of Clinical Chemistry Working Group on Patient Safety, have designed a questionnaire to collect data on prevalence and management of hemolytic specimens referred to the clinical laboratories for clinical chemistry testing. This book will help identify the areas where hemolysis occurs most frequently, which can, in turn, guide further analysis about why it is occurring. Once these elements are known, practices and procedures can be implemented to dramatically reduce hemolysis and avoid erroneous laboratory results affecting patient care and increasing laboratory costs.

Read more less

Book SynopsisThe subject matter of volume 1 of the 2-volumes-handbook focusses on leiomyosarcoma, low-grade and high-grade endometrial sarcoma and undifferentiated uterine sarcoma of the whole female genitalia. A separate extensive chapter is devoted to the variants of leiomyoma (angio-, lipo-, cotyledonoid, cellular, mitotically active, epithelioid and myxoid leiomyoma, leiomyoma with bizarre nuclei), atypical smooth muscle tumors (smooth muscle tumors with uncertain malignant potential), and disseminated peritoneal leiomyomatosis, benign metastasizing leiomyoma, and intravenous leiomyomatosis. Furthermore, endometrial stromal tumors – endometrial stromal nodules, endometrial stromal tumor with sex cord-like elements (ESTSCLE), uterine tumor resembling ovarian sex-cord tumor (UTROSCT) - and similar tumors are described in detail. The book provides a description at length of the epidemiology, etiology, pathological anatomy, prognosis, diagnosis, differential diagnosis, imaging and comprehensive therapy of each primary, relapsed, and metastasized tumor including surgery, chemo-, hormone- and radio- and targeted therapy. Another chapter is devoted to the prevention of subjecting sarcomas to inadequate surgical therapeutic measures under the assumed diagnosis of leiomyoma, and includes a diagnostic-therapeutic flowchart with a diagnostic score. The book aims to identify and provide diagnostic and therapeutic guidance. The listed tumor entities also constitute a particular diagnostic challenge for pathologists that contains numerous pitfalls and difficulties. This book, therefore, addresses gynecologists and pathologists in both clinical and private practice, but also surgeons and hemato-oncologists.

Read more less

Book SynopsisThe subject matter of volume 2 of the 2-volumes-handbook focusses especially on rare sarcomas of the whole female genitalia. These entities include angiosarcoma, the different lipo- and rhabdomyosarcoma as well as newer entities like the PEComa. Furthermore, mixed mullerian tumors like the benign adenofibroma and the malignant adenosarcoma and carcinosarcoma are described in detail. The book provides a description at length of the epidemiology, etiology, pathological anatomy, prognosis, diagnosis, differential diagnosis, imaging and comprehensive therapy of each primary, relapsed, and metastasized tumor including surgery, chemo-, hormone- and radio- and targeted therapy. An own chapter is devoted to the problems of fertility and pregnancy in connection with all sarcomas, variants of leiomyoma, atypical smooth muscle tumors, disseminated peritoneal leiomyomatosis, benign metastasizing leiomyoma, intravenous leiomyomatosis and endometrial stromal tumors – endometrial stromal nodules, endometrial stromal tumor with sex cord-like elements (ESTSCLE), uterine tumor resembling ovarian sex-cord tumor (UTROSCT) -and all mixed tumors - of the female genitalia. The book aims to identify and provide diagnostic and therapeutic guidance. The listed tumor entities also constitute a particular diagnostic challenge for pathologists that contains numerous pitfalls and difficulties. This book, therefore, addresses gynecologists and pathologists in both clinical and private practice, but also surgeons and hemato-oncologists.

Read more less

Book SynopsisThere have been a number of significant changes in transfusion science in the last five to ten years and this second edition of Transfusion Science covers these in some detail. * A new chapter introduces readers to the current applications of emerging techniques in transfusion science. * Platelet immune disorders and haemolytic anaemias are now covered. * The need for leucodepletion and methods for pathogen reduction are described. * The latest nomenclature for blood group genes has been adopted. * Current practice in blood group serology is reviewed. * Recent legislative changes for quality assurance in transfusion in the UK are now also covered. Case studies and colour photographs are now provided to illustrate concepts and to aid understanding, and a revised series of self-assessment questions and learning outcomes are also provided. An understanding of transfusion science is vital for all biomedical science students. Transfusion Science, second edition, explains all the basic principles alongside descriptions of the applications now possible as a result of modern analytical techniques. This book is essential reading for all students studying courses on transfusion and transplantation.Table of Contents1. The immune system 1.1 Immunology and transfusion science; 1.2 The immune system; 1.3 Two types of immune defence; 1.4 Non-specific defences; 1.5 Non-specific responses to tissue damage and infection; 1.6 The specific immune response; 1.7 Cells of the specific immune response 2. Antibodies and antigens 2.1 History of antibodies; 2.2 Antibodies are immunoglobulins; 2.3 Kinetics of the antibody response; 2.4 Immunoglobulin isotypes; 2.5 Antibody structure; 2.6 Binding of an antibody to an epitope; 2.7 Effector role of the antibody 3. Complement 3.1 Historical context; 3.2 Complement is not a single entity; 3.3 The classical pathway: activation to lysis; 3.4 Other biological activities of complement; 3.5 Alternative pathway for complement activation; 3.6 The lectin pathway; 3.7 Physiological regulation of complement activation; 3.8 Complement in transfusion science 4. Genetics for blood groups 4.1 Genetics and blood groups; 4.2 DNA and chromosomes; 4.3 The structure and role of genes; 4.4 DNA replication and protein synthesis; 4.5 Blood groups and molecular events in genes; 4.6 Inheritance of blood group genes 5. Introduction to blood groups: the ABO blood group system 5.1 Introduction; 5.2 Blood group nomenclature; 5.3 The ABO blood group system; 5.4 The biochemical nature of the A and B antigens; 5.5 genes involved in the ABO system; 5.6 Secretors of A,B and H sugars; 5.7 The FUT1 (H) gene and the Bombay blood groups; 5.8 Inheritance and molecular genetics of the ABO groups; 5.9 Sub-groups of A and B blood groups; 5.10 Population distribution of the ABO groups; 5.11 The distribution of ABO determining antigens; 5.12 ABO blood group antibodies 6 The Rh blood group system 6.1 Introduction to the Rh system; 6.2 Inheritance and nomenclature of the Rh system; 6.3 Fisher' s dce system; 6.4 Two locus model; 6.5 Qualitative differences in Rh antigens; 6.6 Quantitative differences in Rh antigens; 6.7 Laboratory aspects of Rh blood group typing 7. Other blood group systems 7.1 Carbohydrate antigens; 7.2 Protein antigens; 7.3 Importance of other blood groups in transfusion science 8. Immune and auto immune haematology disorders 8.1 Mechanisms of red cell destruction; 8.2 Causes and classification of immune haemolytic anaemia; 8.3 Haemolytic transfusion reactions; 8.4 Warm auto immune haemolytic anaemia; 8.5 Cold haemolytic anaemia; 8.6Underlying mechanisms which may cause immune/auto immune haemolytic anaemia; 8.7 Drug induced haemolytic anaemia; 8.8 Laboratory tests for diagnosis of auto immune / immune haemolytic anaemia; 8.9 Haemolytic disease of the newborn; 8.10 Immune disorders affecting platelets 9. Blood products and components 9.1 Introduction to blood components; 9.2 Blood components for transfusion; 9.3 Plasma derived blood components; 9.4 Plasma derived products from single donations; 9.3 Quality assurance procedures for blood and blood products 10. Haemagglutination and blood grouping methods 10.1 Introduction; 10.2 Haemagglutination; 10.3 Methods; 10.4 Technical considerations; 10.5 Associated technical considerations; 11. Adverse effects of transfusion 11.1 General precautions; 11.2 Adverse effects caused by transmission of infectious agents; 11.3 Adverse reactions due to the transfusion of red; cells; 11.4 Adverse reactions due to the transfusion of leucocytes; 11.5 Adverse reactions due to the transfusion of platelets; 11.6 Adverse reactions due to the transfusion of plasma; 11.7 Adverse reactions due to other causes; 11.8 Investigation of an alleged reaction to a red cell transfusion; 11.9 Summary 12. Stem cell processing and transplantation 12.1 Introduction; 12.2 Some useful definitions; 12.3 Clinical situations requiring a haemopoietic stem cell transplant; 12.4 Sources and processing of haemopoietic stem cells for transplant; 12.7 Transfusion support post transplant; 12.7 Problems associated with the transplantation of haemopoietic stem cell transplants; 12.8 The major histocompatibility complex; 12.9 The HLA system;l; 12.10 Availability and choice of donors 13. Applications of molecular and immunological techniques 13.1 Introduction ; 13.2 Molecular techniques for the identification of blood groups; 13.3 Applications of molecular techniques; 13. 4 Further applications of molecular techniques; 13.5 Immunological techniques using flow cytometry

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less