Haematology Books

Book SynopsisAre you constantly exhausted? Does sleep not refresh you? Is your balance not what it was? Do you have tingling or even burning in your fingers and toes? Then your problem may be vitamin B12 deficiency. Your doctor may test you for this but your blood levels look OK so what should you do then? Or you may receive treatment but not feel any better? This book is a guide to the complexities of this deceptively simple problem - how it can be diagnosed, how it can be treated, and how those who have it can cope with the lifelong repercussions. Incorporating the latest research, and the input of the thousands of members of the Pernicious Anaemia Society, this book is both practical and engaging, illustrated with many personal stories that will resonate with sufferers and their friends and families.Table of ContentsIntroduction; Blood, Anaemia, Pernicious Anaemia and Vitamin B12 Deficiency; Causes of vitamin B12 deficiency; Problems with Assessing Vitamin B12 Deficiency; Problems with Diagnosing Pernicious Anaemia; Problems with the Treatment of Pernicious Anaemia; The consequences of pernicious anaemia; Associated health conditions; Current trends and future developments; Ten frequently asked questions

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Book SynopsisTable of Contents1. Effective use of laboratory tests 2. Interpreting laboratory tests 3. The urea and electrolyte (U&E) profile - Sodium - Potassium - Bicarbonate - Chloride - Urea - Creatinine - Estimated glomerular filtration rate (eGFR) - Other tests of kidney function 4. The bone profile - Calcium - Phosphate - Albumin - Alkaline phosphatase (ALP) 5. The liver profile - Bilirubin - Alanine aminotransferase (ALT) - Aspartate aminotransferase (AST) - Gamma glutamyl transpeptidase (GGT) - Alkaline phosphatase (ALP) 6. Blood gas analysis and pH 7. Endocrine testing - Pituitary function - Adrenal function - Thyroid function - Gonadal function - Other hormones 8. Blood proteins 9. Enzymes 10. Glucose and other tests relevant to diabetes mellitus 11. Lipids and other tests relevant to cardiovascular disease 12. Tumour markers 13. Assessing nutrition 14. Heavy metals 15. Therapeutic drug monitoring 16. Poisoning 17. The full blood picture (FBP) - Haemoglobin - White cell count - Platelet count - Red cell indices - Blood film interpretation 18. Tests of coagulation 19. Blood grouping 20. Testing during pregnancy 21. Testing during childhood 22. Metabolic disorders 23. Analysis of body fluids other than blood - Urine - Pleural fluid - Peritoneal fluid - Cerebrospinal fluid - Synovial fluid

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Book SynopsisHemostasis and Thrombosis , Sixth EditionSince publication of the First Edition in 1982, Hemostasis and Thrombosis has established itself as the pre-eminent book in the field of coagulation disorders. No other book is as inclusive in scope, with coverage of the field from the standpoint of both basic scientists and clinicians. This comprehensive resource details the essentials of bleeding and thrombotic disorders and the management of patients with these and related problems, and delivers the most up-to-date information on normal biochemistry and function of platelets or endothelial cells, as well as in-depth discussions of the pharmacology of anticoagulant, fibrinolytic, and hemostatic drugs. NEW to the Sixth Edition…• A new team of editors , each a leader in his field, assures you of fresh, authoritative perspectives.• Full color throughout• A companion website that offers full text online and an image bank.• A new introductory section of chapters on basic sciences as related to the field• Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women's health issues, cancer, sickle cell disease, and other groups.• Overview chapters preceding each section address broad topics of general importance.

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Book SynopsisWritten by national recognized experts and senior fellows at leading research institutions, including the National Institutes of Health, and edited by Drs. Griffin P. Rodgers and Neal S. Young, The Bethesda Handbook of Clinical Hematology, 5th Edition, is a concise, comprehensive handbook designed for everyday clinical use. Organized in a quick-reference, portable format, it covers the clinical information you need to know for the diagnosis and treatment all of blood and bone marrow disorders. Readable and practical, the Bethesda Handbook features numerous tables, algorithms, illustrations, and bulleted lists throughout to help bridge the gap between cutting-edge science and everyday clinical practice. Provides clinically focused, authoritative, and current guidance in this complex area, logically organized by disease category Discusses the pathophysiology, natural history, risk factors, diagnosis, management, and follow-up of common hematological diseases Features new diagnostic and treatment strategies, updated references, and revised information throughout An ideal resource for practitioners at every level of training: students, residents, and fellows on a hematology or oncology service, as well as internists, hospitalists, family practitioners, pediatricians, and nurse practitioners whose practice includes patients with blood diseases

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Book SynopsisHuman Blood Groups is a comprehensive and fully referenced text covering both the scientific and clinical aspects of red cell surface antigens, including: serology, inheritance, biochemistry, molecular genetics, biological functions and clinical significance in transfusion medicine. Since the last edition, seven new blood group systems and over 60 new blood group antigens have been identified. All of the genes representing those systems have now been cloned and sequenced. This essential new information has made the launch of a third edition of Human Blood Groups, now in four colour, particularly timely. This book continues to be an essential reference source for all those who require clinical information on blood groups and antibodies in transfusion medicine and blood banking.Trade Review “It is fascinatingly detailed, and makes a wonderful book for browsing, with many interesting facts, often with historical context to each blood group discovery; but its main audience will be those working within the transfusion laboratory, for whom this will be an invaluable reference.” (Haem Trainee, 1 August 2013) “Get it. If you are involved in blood banking, this is a must-have.” (Doody’s, 14 June 2013)Table of ContentsForeword, vii Preface to the third edition, viii Some abbreviations used, ix 1 Human blood groups: introduction, 1 2 ABO, H, and Lewis systems, 11 3 MNS blood group system, 96 4 P1PK, Globoside, and FORS blood group systems, plus some other related blood groups, 162 5 Rh and RHAG blood group systems, 182 6 Lutheran blood group system, 259 7 Kell and Kx blood group systems, 278 8 Duffy blood group system, 306 9 Kidd blood group system, 325 10 Diego blood group system, 336 11 Yt blood group system, 354 12 Xg blood group system, 359 13 Scianna blood group system, 371 14 Dombrock blood group system, 376 15 Colton blood group system, 384 16 LW blood group system, 391 17 Chido/Rodgers blood group system, 400 18 Gerbich blood group system, 410 19 Cromer blood group system, 427 20 Knops blood group system and the Cost antigens, 439 21 Indian blood group system and the AnWj antigen, 449 22 Ok blood group system, 457 23 Raph blood group system, 461 24 JMH blood group system, 465 25 I and i antigens, and cold agglutination, 469 26 Gill blood group system, 485 27 Junior and Langereis blood group systems, 487 28 Er antigens, 493 29 Low frequency antigens, 495 30 High frequency antigens, including Vel, 500 31 Sid antigen, 505 32 HLA (Human Leucocyte-Associated) Class I antigens on red cells, 512 33 Polyagglutination and cryptantigens, 515 Index, 524

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Book SynopsisThis comprehensive book is written to inform and improve outcomes of patients in need of blood management during surgical procedures. Information is presented in an accessible format, allowing for immediate use in clinical practice.Beginning with an overview of the history of blood transfusions, early chapters present the foundational information needed to comprehend information in later chapters. Nuanced procedures, drugs, and techniques are covered, including new biologicals to assist clotting and blood substitutes. Further discussions focus on potential complications seen in blood transfusions, such as diseases of the coagulation system, pathogen transmissions, and acute lung injuries. Chapters also examine the complexities of treating specific demographics, of which include the geriatric patient and patients suffering from substance abuse. Essentials of Blood Product Management in Anesthesia Practice is an invaluable guide for anesthesiologists, surgeons, trauma physicians, and solid organ transplant providers.Table of ContentsThe History of Blood Transfusions Modern Blood Banking Component Therapy and Whole Blood: Packed Red Blood Cells, Fresh Frozen Plasma, Cryoprecipitate, washed and or radiated red cells The Coagulation System and Clot Stability Fibrinolysis- Tranexamic Acid and Aminocaproic Acid. Hypercoagulation and Thrombotic Disorders: TTP, Factor 5 Leiden, Phospholipid Syndrome, Anti-thrombin 3, hypereosinophils, oxidative stress, cancer. Diseases or Conditions of Platelet Dysfunction The Massive Transfusion Protocol New Biologicals to Assist Clotting- Riastap, Prothrombin Concentrates. Antithrombin3, Fibrogammin and factor13, Fibrosupernatant, Fibrinogen Concentrates, Recombinant Factor 7, DDAVP, Octaplast G., Factor 10A, KCentra Biologicals that Inhibit Clot generation -The Heparins, Factor 10A inhibitors, rivaroxaban, apixaban, dabigatran, Point of Care Testing and Goal Directed Therapy- Thromboelastography, ROTEM, Platelet function analyzer, stat-PT, thrombin generation assays, multi-electro-aggregometry, OHP (Overall hemostatic potential assay), ACT. Complications of Blood Transfusions: TRALI, TACO, Blood type mismatch, infection Diseases of the Coagulation System- Hemophilia, VonWillebrand Disease, Cryoglobulinemia, Inborn Errors of Factor Synthesis Blood Conservation Strategies and Bloodless Surgery- normovolemic hemodilution, cell saver, Bridges to Transfusion when blood is not immediately available. Artificial Blood Preoperative correction of anemia Blood Deployment in Natural Disasters and the Military in Combat Commonly prescribed medications that affect clotting-anti-depressants, NSAIDS, ASA Anesthesia for the severe trauma patient- new evidence from new trials Old blood vs. new blood- Is storage injury a concern? Vascular Endothelial dysfunction and inflammatory states Liberal or restrictive blood transfusions

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Book SynopsisTable of ContentsSection 1: Introduction 1. Introduction to Peripheral Blood Film Examination Section 2: Hematopoiesis 2. Hematopoiesis 3. Erythrocyte Maturation 4. Megakaryocyte Maturation 5. Neutrophil Maturation 6. Monocyte Maturation 7. Eosinophil Maturation 8. Basophil Maturation 9. Lymphocyte Maturation Section 3: Erythrocytes 10. Variations in Size and Color of Erythrocytes 11. Variations in Shape and Distribution of Erythrocytes 12. Inclusions in Erythrocytes 13. Diseases Affecting Erythrocytes Section 4: Leukocytes 14. Nuclear and Cytoplasmic Changes in Leukocytes 15. Acute Myeloid Leukemia 16. Precursor Lymphoid Neoplasms 17. Myeloproliferative Neoplasms 18. Myelodysplastic Syndromes 19. Mature Lymphoproliferative Disorders 20. Morphologic Changes after Myeloid Hematopoietic Growth Factors Section 5: Miscellaneous 21. Microorganisms 22. Miscellaneous Cells 23. Normal Newborn Peripheral Blood Morphology 24. Body Fluids Glossary Appendix: Comparison Tables

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Book SynopsisTrade ReviewAccolades for Previous Editions: Best Book in Medical Science Award --Association of American Publishers Highly Commended Prize (Internal Medicine) --British Medical Association Medical Book Awards "Belongs on the bookshelf of every clinician who assesses patients with platelet disorders" --The Lancet "Landmark" --New England Journal of Medicine "This is a fantastic resource for anyone who treats patients with platelet disorders or is engaged in platelet or megakaryocyte-based research" --British Journal of HaematologyTable of ContentsPART I: Platelet Biology 1. The Evolution of Mammalian Platelets 2. Megakaryocyte Development and Platelet Formation 3. The Structure of Resting and Activated Platelets 4. Platelet Glycobiology and the Control of Platelet Function and Lifespan 5. Platelet Genomics 6. Platelet MicroRNAs 7. The Platelet Transcriptome in Health and Disease 8. The Platelet Proteome 9. Platelet Receptors 10. The Glycoprotein Ib-IX-V Complex 11. GPVI and CLEC-2 12. Integrin aIIbß3 13. Protease-Activated Receptors 14. The Platelet P2 Receptors 15. Platelet Inhibitory Receptors 16. Interactions Between Platelets, Leukocytes, and the Endothelium 17. Inhibition of Platelet Function by the Endothelium 18. Platelet Signal Transduction 19. Platelet Secretion 20. Hemostatic Thrombus Formation in Flowing Blood 21. Interactions Between Platelets and the Coagulation System 22. Platelet-Derived Extracellular Vesicles 23. Regulation of Fibrinolysis by Platelets 24. The Role of Platelets in Angiogenesis 25. Platelet Function in the Newborn PART II: The Role of Platelets in Disease 26. The Role of Platelets in Atherothrombosis 27. The Role of Platelets in Diabetes Mellitus 28. The Role of Platelets in Inflammation 29. The Role of Platelets in Antimicrobial Host Defense 30. The Role of Platelets in Tumor Growth, Metastasis, and Immune Evasion 31. The Role of Platelets in Sickle Cell Disease PART III: Clinical Tests of Platelet Function 32. Platelet Counting 33. Clinical Tests of Platelet Function 34. Platelet Aggregation 35. Flow Cytometry 36. Laboratory Monitoring of Antiplatelet Therapy 37. Platelet Function Testing in Clinical Research Trials PART IV: Disorders of Platelet Number and/or Function 38. The Clinical Approach to Disorders of Platelet Number and Function 39. Immune Thrombocytopenia (ITP) 40. Drug-Induced Thrombocytopenia 41. Heparin-Induced Thrombocytopenia 42. Thrombotic Thrombocytopenic Purpura and Hemolytic-Uremic Syndromes 43. Thrombocytopenia in Pregnancy 44. Thrombocytopenia in the Newborn 45. Alloimmune Thrombocytopenia 46. Inherited Thrombocytopenias 47. Thrombocytosis and Essential Thrombocythemia 48. Inherited Disorders of Platelet Function 49. Acquired Disorders of Platelet Function PART V: Antiplatelet Therapy 50. Aspirin 51. P2Y12 Antagonists 52. aIIbß3 (GPIIb-IIIa) Antagonists 53. PAR-1 Antagonists 54. Phosphodiesterase Inhibitors 55. Novel Antiplatelet Therapies 56. Antiplatelet Drugs in the Management of Coronary Artery Disease 57. Antiplatelet Drugs in the Management of Cerebral Ischemia 58. Antiplatelet Drugs in the Management of Thrombotic/Ischemic Events in Peripheral Artery Disease 59. Antiplatelet Drugs in the Management of Venous Thromboembolism, Cardioembolism, Ventricular Assist Devices, and Pregnancy Complications 60. Antiplatelet Drugs in the Management of Thrombotic/Ischemic Events in Children PART VI: Therapy to Increase Platelet Numbers and/or Function 61. Thrombopoietin Receptor Agonists 62. Desmopressin (DDAVP) 63. Factor VIIa 64. Platelet Transfusion Medicine 65. Therapeutic Platelet-Rich Plasma in Wound Healing 66. Stem Cell-Derived Platelets 67. Gene Therapy for Platelet Disorders

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Book SynopsisThe Oxford Handbook of Clinical Haematology provides core and concise information on the entire spectrum of blood disorders affecting both adults and children. Updated for its fourth edition, it includes all major advances in the specialty, including malignant haematology, haemato-oncology, coagulation, transfusion medicine, and red cell disorders, with a brand new chapter on rare diseases. Practically focused, and specifically designed for ease-of-use, and rapid access to the information you need, this handbook is an indispensable resource on all aspects of haematology for all trainee doctors, nurses, technicians, and research professionals.The handbook is divided into clinical approach and disease-specific areas. The clinical approach section outlines various symptoms and signs in patients with blood disease to enable the reader to formulate a sensible differential diagnosis beofre embarking on investigation and treatment. The disease-specific section is written by four authors whose expertise covers the whole breadth of diseases included in the book. All authors have contributed to national guidelines (e.g. British Committee for Standards in Haematology, BCSH) and are experts in the evidence base that exists for each topic. The Oxford Handbook of Clinical Haematology offers a concise and logical approach to caring for patients with diseases of the blood.Trade ReviewThis new edition follows the tradition of the highly respected Oxford medical handbook series which is a compact, well produced book brimming with knowledge that will help the clinician in a large number of situations. * Dr Harry Brown, glycosmedia.com *Table of Contents1. Clinical approach ; 2. Red cell disorders ; 3. White blood cell abnormalities ; 4. Leukaemia ; 5. Lymphoma ; 6. Myelodysplasia ; 7. Myeloproliferative neoplasms (MPNs) ; 8. Paraproteinaemias ; 9. Haematopoietic stem cell transplantation (SCT) ; 10. Haemostasis and thrombosis ; 11. Immunodeficiency ; 12. Paediatric haematology ; 13. Haematological emergencies ; 14. Supportive care ; 15. Protocols and procedures ; 16. Haematological investigations ; 17. Blood transfusion ; 18. Rare diseases ; A1 Haematology online ; A2 Charts and nomograms ; A3 Normal ranges

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Book SynopsisTable of ContentsIsaacs: Hoffman and Abeloff's Hematology-Oncology Review 1. Cancer biology and Genomics 2. Tumor Immunology 3. Anti-Cancer Therapies SECTION 1: Chemotherapy SECTION 2: Immunotherapy, antibodies, vaccines and pathway inhibitors 4. Clinical Trial Design and Ethics 5. Hereditary Cancer Syndromes HEMATOLOGIC MALIGNANCIES 6. Acute Myeloid Leukemia and Myelodysplastic Syndrome 7. Myeloproliferative Disorders 8. Chronic Lymphocytic Leukemia, Hairy Cell Leukemia, and other Chronic Lymphoproliferative Disorders 9: Hodgkin lymphoma 10. Non-Hodgkin Lymphoma 11. Multiple myeloma and other plasma cell dyscrasias 12. T cell and NK cell neoplasms and other lymphoid malignancies 13. Hematopoeietic Cell Transplantation SOLID TUMOR MALIGNANCIES 14. Breast cancer a: Early Stage Breast Cancer b: Metastatic breast cancer e. Premalignant breast conditions and in situ disease 15. Lung Cancer a: Non-small cell lung cancer b: Small cell lung cancer 16. Other Thoracic Malignancies a: Mesothelioma b: Thymoma and thymic cancer 17. Head and Neck cancer 18 : Esophageal Cancer 19: Gastric cancer 20: Pancreatic cancer 21: Colorectal cancer and Anal Cancer 22: Hepatobiliary cancer 23: Neuroendocrine, small bowel and appendiceal malignancies 24. Prostate cancer 25. Bladder and other urothelial cancers 26. Renal Carcinomas 27. Germ cell tumors 28. Gynecological Malignancies Ovarian Cancer and Fallopian Tube Cancer Cancer of the Cervix, Uterus, Vagina, Vulva and Gestational Choriocarcinoma 29. Melanoma and other skin cancers 30. Bone and soft tissue sarcoma 31.Cancer of unknown primary site 32. . Malignancies of the Central Nervous System a. Primary b. Metastatic NONMALIGNANT HEMATOLOGIC CONDITIONS 33. Coagulation 34. Hematopoietic System 1: Hematopoietic System Disorders RBC or iron 35. Transfusion Medicine SURVIVORSHIP AND END OF LIFE CARE Chapter 36. Supportive Care

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Book SynopsisTrade Review"This comprehensive book is well conceived, well organized, and well presented. This impressive and authoritative work embodies a formal textbook on hemostasis and thrombosis." -Ravi Salgia, MD, PhD (City of Hope) Doody's Score: 100-5 Stars!Table of ContentsKitchens: CONSULTATIVE HEMOSTASIS & THROMBOSIS TOC PART 1: Hemorrhagic Processes 1. Consultative Process 2. An Approach to the Bleeding Patient: Correlation of Clinical Symptoms and Signs with Laboratory Testing 3. Hemophilia A and B 4. Less Common Congenital Disorders of Hemostasis 5. Acquired Coagulation Disorders Due to Inhibitors 6. von Willebrand Disease 7. General Aspects of Thrombocytopenia, Platelet Transfusions, and Thrombopoietic Growth Factors 8. Primary Immune Thrombocytopenia 9. Congenital and Acquired Disorders of Platelet Function and Number 10. Purpura and Other Hematovascular Disorders 11. HHT 12. Disseminated Intravascular Coagulation 13. The Cross-Talk of Inflammation and Coagulation in Infectious Disease and Their Roles in Disseminated Intravascular Coagulation PART 2: Thrombotic Processes 14. Thrombophilia: Clinical and Laboratory Assessment and Management 15. Pediatric Aspects of Thrombophilia 16. Deep Vein Thrombosis, Pulmonary Embolism and Primary Pulmonary Hypertension 17. Venous Thromboses at Unusual Sites 18. The Post Thrombotic Syndrome 19. Thrombocytosis: Essential Thrombocytemia and Reactive Causes 20. Antiphospholipid Syndrome 21. Antiplatelet Treatment in Cardiovascular Medicine 22. Non-Arteriosclerotic Arterial Occlusive Disease 23. Thrombosis and Cancer 24. Thrombotic Thrombocytopenic Purpura 25. Hemostatic Disorders of Complement Activation (PNH and aHUS) - New Chapter 26. Heparin-Induced Thrombocytopenia PART 3: Therapeutic Agents 27. Antithrombotic Agents 28. Blood Component and Pharmacological Agents 29. Therapeutic Apheresis â?" Applications for Hemorrhagic & Thrombotic Disorders 30. Vena Caval Filters PART 4: Issues Specific to Women 31. Thrombotic Risk of Contraceptives and other Hormnal Therapies 32. Bleeding and the Management of Hemorrhagic Disorders in Pregnancy 33. Thrombophilia in Pregnancy PART 5: Special Issues 34. Surgery and Hemostasis 35. Anticoagulation in the Perioperative Period 36. Understanding and Managing the Coagulopathy of Liver Disease 37. Outpatient Anticoagulant Therapy38. Hematologic Interventions for Acute Central Nervous System Disease 39. Pending: Atrial Septal Abnormalties and Cryptogenic Stroke 40. Hemorrhage Control and Thrombosis Following Severe Injury 41. Hemostatic Aspects of Sickle Cell Disease

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Book SynopsisTrade Review"This is a great addition to the current offerings of clinical hematology or hematopathology atlases, filling a specialized and practical niche where these clinical services intersect in real life (e.g., tumor boards).” - ©Doody's Review Service, 2021, Valerie L. Ng, PhD, MD (Alameda County Medical Center/Highland Hospital) Doody's Score: 90 - 4 Stars!Table of ContentsNormal Hemopoiesis and Blood Cell Maturation Growth Factors Hypochromic and Hemolytic Anemias Megaloblastic Anemia Myeloproliferative Neoplasms Mast Cell and Non-Myeloproliferative Myeloid Neoplasms Myelodysplastic Syndromes Acute Myeloid Leukemia Precursor Lymphoid Neoplasms B-Cell Chronic Lymphoid Leukemias Hodgkin Lymphoma Indolent and Aggressive B-Cell Lymphoma Indolent and Aggressive Mature T-Cell and Natural Killer-Cell Lymphomas Myeloma and Related Conditions Childhood Hematopoietic Disorders Posttransplant Lymphoproliferative Disorders and Immunodeficiency Infectious Processes in Blood and Bone Marrow Hemophilia Transfusion Medicine and Cellular Therapy

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Book SynopsisTable of ContentsPart 1. Cytotoxic Chemotherapy 1. Mechanism of Chemotherapy in Cancer Treatment 2. Neutropenic Complications of Chemotherapy 3. Chemotherapy Induced Anemia 4. Cancer Treatment Related Thrombocytopenia 5. Oral Mucositis 6. Gastrointestinal Complications of Chemotherapy 7. Neurological Complications 8. Pulmonary Toxicities of Cytotoxic Chemotherapy 9. Dermatological Complications of Chemotherapy 10. Cardiotoxicities of Chemotherapy 11. Management of Cancer Treatment Infusion Reactions Part 2. Targeted Therapies 12. Mechanism of Targeted Therapies in Cancer Treatment 13. Gastrointestinal Complications 14. Pulmonary Toxicities of Molecular Targeted Therapies 15. Dermatologic Toxicities 16. Cardiotoxicities Part 3. Immunotherapies 17. Mechanism of Immune-Related Adverse Events 18. Endocrine Toxicities 19. Gastrointestinal Toxicities 20. Neurological Complications of Immunotherapy 21. Pulmonary Toxicities 22. Dermatological Complications 23. Immunotherapy-Induced Cardiotoxicities 24. Rheumatological Complications Part 4. Radiation Therapy 25. Mechanisms of Radiation-Related Toxicities 26. Radiation-Induced Mucositis and Esophagitis 27. Radiation Therapy Related Dermatologic Toxicities 28. Pulmonary Toxicity from Radiation Therapy 29. Radiation-Induced Cardiotoxicities

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Book SynopsisTrade Review"The breadth and meticulous detail of this book are a testament to its editors, all of whom are internationally regarded experts in hematology." © The ASCO Post 2023, Ronald PianaTable of ContentsPART I MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY 1. Anatomy and Physiology of the Gene 2. Epigenomics in Hematology 3. Genomic Approaches to Hematology 4. Regulation of Gene Expression in Hematology 5. Genome Editing 6. Signaling Transduction and Metabolomics 7. Protein Architecture: Relationship of Form and Function 8. Pharmacogenomics and Hematologic Diseases PART II CELLULAR BASIS OF HEMATOLOGY 9. Hematopoietic Stem Cell Biology 10. Mitochondria and Hematopoiesis 11. Cytokines, Chemokines, Other Growth Factors, and Their Receptors 12. Role of Chemokines in Leukocyte Trafficking 13. Stem Cell Model of Hematologic Diseases 14. Hematopoietic Microenvironment 15. Cell Adhesion 16. Current Biology of Stem Cell Homing and Mobilization: Dynamic Interactions Between Hematopoietic Stem and Progenitor Cells and Their Surrounding Bone Marrow Microenvironment 17. Control of Cell Division 18. Cell Death 19. Aging and Hematopoiesis PART III IMMUNOLOGIC BASIS OF HEMATOLOGY 20. Dendritic Cell Biology 21. Natural Killer Cell Immunity and Therapy 22. B-Cell Development 23. Complement and Immunoglobulin Biology Leading to Clinical Translation 24. T-Cell Immunity 25. Unmodified Ex Vivo Expanded T Cells 26. Treatment of Hematologic Malignancies with Genetically Modified T Cells PART IV DISORDERS OF HEMATOPOIETIC CELL DEVELOPMENT 27. Biology of Erythropoiesis, Erythroid Differentiation, and Maturation 28. Granulocytopoiesis and Monocytopoiesis 29. Thrombocytopoiesis 30. Inherited Bone Marrow Failure Syndromes 31. Aplastic Anemia 32. Paroxysmal Nocturnal Hemoglobinuria 33. Acquired Disorders of Red Cell, White Cell, and Platelet Production PART V RED BLOOD CELLS 34. Pathobiology of the Human Erythrocyte and Its Hemoglobins 35. Approach to Anemia in the Adult and Child 36. Iron Homeostasis and Its Disorders 37. Disorders of Iron Homeostasis: Iron Deficiency and Overload 38. Anemia of Chronic Inflammation 39. Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias 40. Megaloblastic Anemias 41. Thalassemia Syndromes 42. Pathobiology of Sickle Cell Disease 43. Clinical Aspects of Sickle Cell Disease 44. Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias 45. Red Blood Cell Enzymopathies 46. Red Blood Cell Membrane Disorders 47. Autoimmune Hemolytic Anemia 48. Extrinsic Nonimmune Hemolytic Anemias PART VI NON-MALIGNANT LEUKOCYTES 49. Neutrophilic Leukocytosis, Neutropenia, Monocytosis, and Monocytopenia 50. Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia 51. Disorders of Phagocyte Function 52. Congenital Disorders of Lymphocyte Function 53. Pediatric and Adult Histiocytic Disorders 54. Lysosomal Storage Diseases, Focusing on Gaucher Disease: Perspectives and Principles 55. Epstein-Barr Virus and Associated Lymphoproliferative Conditions PART VII HEMATOLOGIC MALIGNANCIES 56. Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications 57. Conventional and Molecular Cytogenomic Basis of Hematologic Malignancies 58. Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies 59. Pathobiology of Acute Myeloid Leukemia 60. Clinical Manifestations and Treatment of Acute Myeloid Leukemia 61. Myelodysplastic Syndromes 62. Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults 63. Acute Myeloid Leukemia in Children 64. Blastic Plasmacytoid Dendritic Cell Neoplasm 65. Myelodysplastic Syndromes and Myeloproliferative Neoplasms in Children 66. Pathobiology of Acute Lymphoblastic Leukemia 67. Clinical Manifestations and Treatment of Childhood Acute Lymphoblastic Leukemia 68. Acute Lymphoblastic Leukemia in Adults 69. Chronic Myeloid Leukemia 70. The Polycythemias 71. Essential Thrombocythemia 72. Primary Myelofibrosis and Chronic Neutrophilic Leukemia 73. Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes 74. Eosinophilia, Eosinophilic Neoplasms, and the Hypereosinophilic Syndromes 75. Mast Cells and Mastocytosis 76. Chronic Lymphocytic Leukemia 77. Hairy Cell Leukemia 78. The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas 79. Origin of Hodgkin Lymphoma and Therapeutic Targets 80. Hodgkin Lymphoma 81. Origin of Non-Hodgkin Lymphoma and Therapeutic Targets 82. Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma 83. Marginal Zone Lymphomas (Extranodal/MALT, Splenic, and Nodal) 84. Diffuse Large B-Cell Lymphoma of the Central Nervous System 85. High-Grade B-Cell Lymphomas 86. Mantle Cell Lymphoma 87. Virus-Associated Lymphoma 88. Malignant Lymphomas in Childhood 89. T-Cell Lymphomas 90. Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma 91. Multiple Myeloma 92. Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma 93. Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis) PART VIII COMPREHENSIVE CARE OF PATIENTS WITH HEMATOLOGIC MALIGNANCIES 94. Key Considerations for Managing Infections in the Compromised Host 95. Principles of Radiation Therapy for Hematologic Disease 96. Grading and Toxicity Management after Immune Effector Therapy 97. Identification and Management of Checkpoint Inhibition Toxicity 98. Psychosocial Aspects of Hematologic Disorders 99. Pain Management and Antiemetic Therapy in Hematologic Disorders 100. Palliative Care 101. Therapy-related Late Effects of Hematologic Malignancies PART IX TRANSPLANTATION AND OTHER CELL-BASED THERAPIES 102. Practical Aspects of Hematopoietic Stem Cell Harvesting and Mobilization 103. Graft Engineering and Cell Processing 104. Principles of Cell-Based Genetic Therapies 105. Indications, Outcomes, and Donor Selection for Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults 106. Unrelated Donor Hematopoietic Cell Transplantation 107. Haploidentical Hematopoietic Stem Cell Transplantation 108. Cord Blood Transplantation 109. Graft-versus-Host Disease and Graft-versus- Leukemia Responses 110. Supportive Care for the Transplant Patient PART X TRANSFUSION MEDICINE 111. Human Blood Group Antigens and Antibodies 112. Principles of Red Blood Cell Transfusion 113. Clinical Considerations in Platelet Transfusion Therapy 114. Human Leukocyte Antigen and Human Neutrophil Antigen Systems 115. Principles of Plasma and Plasma Derivatives 116. Hemapheresis 117. Transfusion Reactions to Blood and Hematopoietic Stem Cell Therapy Products 118. Transfusion-Transmitted Diseases 119. Pediatric Transfusion Medicine 120. Transfusion and Apheresis Support for Sickle Cell Disease Patients PART XI HEMOSTASIS AND THROMBOSIS 121. Overview of Hemostasis and Thrombosis 122. Blood Vessels 123. Megakaryocyte and Platelet Structure 124. Molecular Basis of Platelet Function 125. Molecular Basis of Blood Coagulation 126. Evaluation of the Patient with Suspected Bleeding Disorders 127. Laboratory Evaluation of Hemostatic and Thrombotic Disorders 128. Acquired Disorders of Platelet Function 129. Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura 130. Thrombocytopenia Caused by Hypersplenism, Platelet Destruction, or Surgery/Hemodilution 131. Heparin-Induced Thrombocytopenia 132. Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndromes 133. Structure, Biology, and Genetics of von Willebrand Factor 134. Hemophilia A and B 135. Rare Coagulation Factor Deficiencies 136. Transfusion Therapy for Coagulation Factor Deficiencies 137. Disseminated Intravascular Coagulation 138. Hypercoagulable States 139. Antiphospholipid Syndrome 140. Venous Thromboembolism 141. Prevention and Treatment of Venous Thromboembolism in Pregnancy 142. Atherothrombosis 143. Antithrombotic Drugs 144. Stroke 145. Acute Coronary Syndromes 146. Peripheral Artery Disease 147. Atrial Fibrillation 148. Bleeding and Clotting Disorders in Pediatrics PART XII CONSULTATIVE HEMATOLOGY 149. Hematologic Changes in Pregnancy 150. Hematologic Manifestations of End-Organ Failure 151. Hematologic Manifestations of Solid Tumors 152. Hematologic Manifestations of HIV/AIDS 153. Hematologic Findings and Consequences of Novel Coronavirus (SARS-CoV-2) Infection 154. Hematologic Aspects of Parasitic Diseases 155. Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis 156. The Spleen and Its Disorders 157. Aging and Hematologic Disorders 158. Onco-cardiology: Focus on Cardiac Complications of Hematologic Treatments 159. Resources for the Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations 2408.e1 Chapter 159 can be found online at Elsevier eBooks for Practicing Clinicians Index

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Book SynopsisTable of Contents1 Laboratory Medicine 2 Statistical Methodologies in Laboratory Medicine 3 Quality Management in the Clinical Laboratory 4 Specimen Collection and Handling 5 Preanalytical Variations and Preexamination Processes 6 Quality Control 7 NEW! Standardization and Harmonization 8 Biological Variations 9 Reference Intervals 10 Evidenced-Based Lab Medicine 11 Biobanking 12 Lab Support of Pharmaceutical, In Vitro Diagnostics and Epidemiologic Studies 13 NEW! Machine Learning and Big Data 14 NEW! Utilization of Laboratory Tests 15 Lab Safety 16 Optical Techniques 17 Electrochemistry and Chemical Sensors 18 Electrophoresis 19 Chromatography 20 Mass Spectrometry 21 Sample Preparation for Mass Spectrometry Applications 22 Mass Spectrometry Applications in Infectious Disease 23 Mass Spectrometry for Small Molecule 24 Proteomics 25 Enzyme and Rate Analysis 26 Immunochemical Techniques 27 Microfabrication and Microfluidics 28 Cytometry 29 Automation in the Clinical Lab 30 Point-of-Care Testing 31 Amino Acids, Peptides, and Proteins 32 Serum Enzymes 33 Tumor Markers 34 Kidney Function Tests 35 Carbohydrates 36 Lipids and Lipoproteins 37 Electrolytes and Blood Gases 38 Hormones 39 Vitamins and Trace Elements 40 Iron Metabolism 41 Porphyrins and Porphyrias 42 Therapeutic Drug Management 43 Clinical Toxicology 44 Toxic Elements 45 Body Fluids 46 Nutrition 47 Diabetes Mellitus 48 Cardiac Function 49 Kidney Disease 50 Disorders of Water, Electrolytes, and Acid-Base Metabolism 51 Liver Disease 52 Gastric, Pancreatic & Intestinal Function 53 Monoamine Producing Tumors 54 Bone and Mineral Metabolism 55 Pituitary Function 56 Adrenal Cortex 57 Thyroid Disorders 58 Reproductive Endocrinology 59 Pregnancy and its Disorders 60 Newborn Screening and Inborn Errors of Metabolism (Small Molecules) 61 Newborn Screening and Inborn Errors of Metabolism (Large Molecules) 62 Principles of Molecular Biology 63 Nucleic Acid Isolation 64 Nucleic Acid Techniques 65 Genomes, Variants, and Massively Paralleled Methods 66 NEW! Clinical Genome Sequencing 67 Molecular Microbiology 68 Genetics 69 Solid Tumors 70 NEW! Hematopathology 71 Circulating Tumor Cells and Circulating Nucleic Acids in Oncology 72 Circulating Nucleic Acids for Prenatal Diagnostics 73 Pharmacogenetics 74 Hemostasis 75 NEW! Hemoglobin and Hemoglobinopathies 76 Automated Hematology 77 Red Blood Cell Morphology and Indices with Clinical Chemistry Interface 78 NEW! White Blood Cell Morphology 79 NEW! Platelets 80 NEW! Enzymes of the RBC 81 NEW! Overview of Infectious Disease 82 NEW! The Role of the Clinical Laboratory in Infection Prevention and Antimicrobial Stewardship 83 Bacteriology 84 Antimicrobial Susceptibility Testing 85 Mycobacteriology 86 Mycology 87 Parasitology 88 Virology 89 Blood Groups and Pretransfusion Testing 90 Blood Components, Products Modifications, and Blood Donor Screening 91 NEW! Indications for Transfusion: RBCs, platelets, plasma, and cryoprecipitate 92 NEW! Transfusion reactions/adverse events associated with transfusion 93 NEW! Allergy Testing 94 NEW! Immunogenicity of Biologics 95 NEW! Systemic Autoimmune Disease (ANA testing, RF, CCP, antibodies, etc. 96 NEW! Primary and secondary immunodeficiencies 97 NEW! Transplant 98 NEW! Immunogenetics Appendix Reference Information for the Clinical Laboratory

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Book SynopsisTable of ContentsTop 100 Secrets Diagnostic Approach to Anemia in Childhood Disorders of Hemoglobin, Normal Development Sickle Cell Syndromes Thalassemia Syndromes Anemia Secondary to Enzyme Deficiencies Anemia Secondary to Membrane Disorders Autoimmune Hemolytic Anemia Anemia Secondary to Nutritional Deficiencies Neonatal Anemia Normal Hemostasis Neonatal Hemostasis Disorders of Coagulation Disorders of Platelets Disorders of the Immune System Disorders of Granulocyte Function and Granulopoiesis Storage Disorders Hematologic Manifestations of Systemic Disease Bone Marrow Failure Syndromes Principles and Practice of Childhood Cancer Genetics, Molecular Genetrics Principles of Chemotherapy Principles of Surgical Oncology Principles of Radition Oncology for Pediatric Malignancy Acute Lymphoblastic Leukemia Acute Myelogenous Leukemia Myeloproliferative Disorders Non-Hodgkin's Lymphoma Hodgkin's Disease Lymphoproliferative Disorders Langerhans Cell Histiocytosis Tumors of the Central Nervous System Retinoblastoma Hepatic Tumors Wilms' Tumor Neuroblastoma Soft Tissue Sarcomas Bone Tumors Germ Cell Tumors Oncologic Emergencies Bone Marrow Transplant/PBSC Principles of Molecular Diagnostics and Therapeutic Supportive Care Late Effects of Childhood Cancer Psycho-social Aspects of Care of the child with Cancer Palliative Care Management of the Dying Child

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Book SynopsisTrade Review"This book has grown since the first edition to maintain its standing as a comprehensive text (including 14 new chapters). Overall, this book provides all the essential knowledge on splenic pathology in one single resource. It is ideal for daily use as a reference but is also an excellent training resource for learners." ©Doody's Review Service, 2022, Anna B Owczarczyk, MD, PHD (University of Michigan Medical School) Doody's Score: 5 Stars!Table of ContentsSECTION 1: HISTOLOGY, FUNCTION, AND DEVELOPMENT OF SPLEEN NORMAL HISTOLOGY 4 Introduction to Spleen Mohammad A. Vasef, MD and Jeremy C. Wallentine, MD 12 Imaging of Splenic Disorders Mohammad A. Vasef, MD 18 Handling, Processing, and Gross Pathology of Spleen Mohammad A. Vasef, MD 26 Fine-Needle Aspiration and Core Biopsy of Spleen Mohammad A. Vasef, MD 32 Immunohistochemistry of Spleen Aaron Auerbach, MD, MPH 40 Flow Cytometry Nadine Aguilera, MD 46 Molecular Techniques Nadine Aguilera, MD SECTION 2: NONNEOPLASTIC SPLENIC DISORDERS LYMPHOID HYPERPLASIA 54 Florid Follicular Hyperplasia Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH 56 Autoimmune Disease Nadine Aguilera, MD 62 HIV in Spleen Nadine Aguilera, MD 68 Castleman Disease Nadine Aguilera, MD 70 Marginal Zone Hyperplasia Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH GRANULOMATOUS LESIONS/DISORDERS 72 Lipogranulomas Jeffrey Vos, MD 78 Sarcoidosis Ellina Hall, DO and Aaron Auerbach, MD, MPH 82 Chronic Granulomatous Disease Aaron Auerbach, MD, MPH INFECTIONS 86 Mycobacteriosis Nadine Aguilera, MD 90 Selected Bacterial Infections Aaron Auerbach, MD, MPH 94 Candidiasis Aaron Auerbach, MD, MPH 96 Histoplasmosis Nadine Aguilera, MD 98 Cryptococcosis Nadine Aguilera, MD 100 Coccidioidomycosis Aaron Auerbach, MD, MPH 104 Pneumocystosis Aaron Auerbach, MD, MPH 108 Infectious Mononucleosis Nadine Aguilera, MD 112 Cytomegalovirus Infection Nadine Aguilera, MD 114 Herpes Simplex Virus Infection Aaron Auerbach, MD, MPH and Nadine Aguilera, MD 116 Echinococcosis Aaron Auerbach, MD, MPH 120 Malaria Nadine Aguilera, MD NONINFECTIOUS CYSTS 122 Epithelial Cyst Ellina Hall, DO and Aaron Auerbach, MD, MPH 124 False Cyst Ellina Hall, DO and Aaron Auerbach, MD, MPH NONNEOPLASTIC VASCULAR PROCESSES 126 Chronic Passive Congestion Ellina Hall, DO and Aaron Auerbach, MD, MPH 128 Infarct Jeffrey Vos, MD 136 Peliosis Ellina Hall, DO and Aaron Auerbach, MD, MPH 138 Sclerosing Angiomatoid Nodular Transformation Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD RED CELL DISORDERS 144 Sickle Cell Disease Aaron Auerbach, MD, MPH and Ellina Hall, DO 146 Thalassemia Nadine Aguilera, MD and Aaron Auerbach, MD, MPH 150 Hereditary Spherocytosis Nadine Aguilera, MD 152 Thrombotic Thrombocytopenic Purpura Aaron Auerbach, MD, MPH MISCELLANEOUS LESIONS/DISORDERS 158 Heterotaxy Syndromes Aaron Auerbach, MD, MPH 160 Congenital Splenic Abnormalities Nadine Aguilera, MD 164 Extramedullary Hematopoiesis Ellina Hall, DO and Aaron Auerbach, MD, MPH 166 Gamna-Gandy Bodies Nadine Aguilera, MD 168 Hemophagocytic Lymphohistiocytosis Nadine Aguilera, MD 174 Immune Thrombocytopenic Purpura Ellina Hall, DO and Aaron Auerbach, MD, MPH 178 Niemann-Pick Disease Meenakshi A. Nandedkar, MD and Nadine Aguilera, MD 184 Gaucher Disease Meenakshi A. Nandedkar, MD and Nadine Aguilera, MD 188 Sea-Blue (Ceroid) Histiocytosis Mohammad A. Vasef, MD 192 Gangliosidosis Lysosomal Disorder Mohammad A. Vasef, MD 194 Therapy Effect on Spleen Aaron Auerbach, MD, MPH 202 Traumatic and Nontraumatic Splenic Injuries Mohammad A. Vasef, MD SECTION 3: NEOPLASTIC SPLENIC DISORDERS BENIGN MESENCHYMAL LESIONS 208 Introduction to Vascular Lesions Nadine Aguilera, MD 210 Hemangioma Nadine Aguilera, MD 218 Lymphangioma Nadine Aguilera, MD 222 Littoral Cell Angioma Nadine Aguilera, MD 228 Inflammatory Pseudotumor Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 236 Postchemotherapy Histiocyte-Rich Pseudotumor of Spleen Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 242 Splenic Hamartoma Nadine Aguilera, MD 246 Myelolipoma Aaron Auerbach, MD, MPH MALIGNANT OR POTENTIALLY MALIGNANT MESENCHYMAL LESIONS 248 Angiosarcoma Nadine Aguilera, MD 256 Hemangioendothelioma Nadine Aguilera, MD 258 Kaposi Sarcoma Nadine Aguilera, MD 260 Leiomyosarcoma Aaron Auerbach, MD, MPH 266 Gastrointestinal Stromal Tumor Aaron Auerbach, MD, MPH 272 Follicular Dendritic Cell Sarcoma Aaron Auerbach, MD, MPH 280 Inflammatory Pseudotumor-Like Follicular Dendritic Cell Sarcoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 286 Langerhans Cell Histiocytosis Guanghua Wang, MD 292 Histiocytic Sarcoma Nadine Aguilera, MD LYMPHOMA 300 Introduction to Lymphoma Mohammad A. Vasef, MD 310 Splenic Marginal Zone Lymphoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 318 Hairy Cell Leukemia Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 326 Hairy Cell Leukemia Variant Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 334 Lymphoplasmacytic Lymphoma Aaron Auerbach, MD, MPH 342 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 350 Follicular Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 358 Mantle Cell Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 366 Leukemic Nonnodal Mantle Cell Lymphoma Mohammad A. Vasef, MD 370 Splenic Diffuse Red Pulp B-Cell Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 376 B-Cell Prolymphocytic Leukemia Aaron Auerbach, MD, MPH and Nadine Aguilera, MD 378 Diffuse Large B-Cell Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 384 Fibrin-Associated Large B-Cell Lymphoma in Splenic False Cyst Mohammad A. Vasef, MD 390 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Jeffrey Vos, MD 398 Burkitt Lymphoma Aaron Auerbach, MD, MPH 406 Classic Hodgkin Lymphoma Jeffrey Vos, MD 416 Nodular Lymphocyte-Predominant Hodgkin Lymphoma Aaron Auerbach, MD, MPH 426 Peripheral T-Cell Lymphoma, Unspecified Mohammad A. Vasef, MD 432 Hepatosplenic T-Cell Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 440 T-Cell Prolymphocytic Leukemia Mohammad A. Vasef, MD 448 T-Cell Large Granular Lymphocytic Leukemia Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 456 Aggressive NK-Cell Leukemia Aaron Auerbach, MD, MPH 462 Transformation of Splenic Disorders Nadine Aguilera, MD LEUKEMIA 466 Acute Myeloid Leukemia Nadine Aguilera, MD 474 Lymphoblastic Leukemia/Lymphoma Nadine Aguilera, MD CHRONIC MYELOPROLIFERATIVE NEOPLASMS/MYELODYSPLASTIC SYNDROMES 480 Myeloproliferative Neoplasm Overview Nadine Aguilera, MD 482 Chronic Myeloid Leukemia, BCR::ABL1 Positive Nadine Aguilera, MD 488 Essential Thrombocythemia Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH 492 Polycythemia Vera Guanghua Wang, MD 496 Primary Myelofibrosis Jeffrey Vos, MD 506 Mastocytosis Mohammad A. Vasef, MD 514 Chronic Myelomonocytic Leukemia Mohammad A. Vasef, MD PLASMA CELL-ASSOCIATED DISORDERS 520 Amyloidosis Nadine Aguilera, MD 526 Heavy Chain Disease Aaron Auerbach, MD, MPH 530 Plasma Cell Myeloma/Plasmacytoma Nadine Aguilera, MD and Aaron Auerbach, MD, MPH METASTASIS 534 Metastatic Tumors Ellina Hall, DO and Aaron Auerbach, MD, MPH

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Book SynopsisTable of ContentsSECTION 1 HEMATOLOGY 1 Innovations in Screening and Management of Neonatal Hyperbilirubinemia 2 The Pivotal Role of Macrophages in the Pathogenesis of Necrotizing Enterocolitis 3 Nucleated Red Blood Cells in Neonatal Medicine 4 Age-Appropriate Biology of Neonatal Neutrophils 5 New Erythrocyte Diagnostic Parameters in Neonatal Medicine 6 Neonatal Iron Homeostasis 7 Risk Factors for Iron Deficiency in Neonates 8 Using Targeted Genetic Panels to Find the Causes of Neonatal Hemolytic Anemia SECTION 2 TRANSFUSION MEDICINE 9 Erythropoietin and Darbepoetin Use in the NICU 10 NICU Transfusion Guidelines and Strategies to Minimize Transfusions 11 Neonatal Blood Banking and Transfusion: Current Questions and Controversies 12 Recent Advances in NICU Platelet Transfusions 13 Novel Approaches to Identify NICU Patients Who Would Benefit From Platelet Transfusions 14 Evidence-Based Guidelines for Administering Fresh Frozen Plasma in the NICU 15 Pathophysiologic Importance of Platelets in Neonatal Necrotizing Enterocolitis Index

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Book SynopsisTable of ContentsPart 1: The Practice of Phlebotomy 1. Introduction to Phlebotomy 2. Anatomy and Physiology 3. Infectious Diseases and Their Prevention 4. Medical Terminology 5. Equipment 6. Proper Procedures for Venipuncture 7. Special Collection Procedures 8. Neonatal and Geriatric Procedures and Considerations 9. Considerations and Complications of Phlebotomy 10. The Versatile Phlebotomist and Point-of-Care Testing Part 2: Professional Issues 11. Interpersonal Communication and Professionalism 12. Phlebotomy Department Management 13. Total Quality in Phlebotomy Service 14. Medical-Legal Issues and Health Law Procedures Appendix A: Answers to Chapter Review Questions Appendix B: Practice Examination for Certification Appendix C: Helpful Spanish Terms and Phrases Glossary Index

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Book SynopsisGeneral Information on Cancer Staging and End-Results Reporting.- Purposes and Principles of Cancer Staging.- Cancer Survival Analysis.- Head and Neck.- Lip and Oral Cavity.- Pharynx.- Larynx.- Nasal Cavity and Paranasal Sinuses.- Major Salivary Glands.- Thyroid.- Mucosal Melanoma of the Head and Neck.- Digestive System.- Esophagus and Esophagogastric Junction.- Stomach.- Small Intestine.- Colon and Rectum.- Anus.- Gastrointestinal Stromal Tumor.- Neuroendocrine Tumors.- Liver.- Intrahepatic Bile Ducts.- Gallbladder.- Perihilar Bile Ducts.- Distal Bile Duct.- Ampulla of Vater.- Exocrine and Endocrine Pancreas.- Thorax.- Lung.- Pleural Mesothelioma.- Musculoskeletal Sites.- Bone.- Soft Tissue Sarcoma.- Skin.- Cutaneous Squamous Cell Carcinoma and Other Cutaneous Carcinomas.- Merkel Cell Carcinoma.- Melanoma of the Skin.- Breast.- Breast.- Gynecologic Sites.- Vulva.- Vagina.- Cervix Uteri.- Corpus Uteri.- Ovary and Primary Peritoneal Carcinoma.- Fallopian Tube.- Gestational Trophoblastic Tumors.- Genitourinary Sites.- Penis.- Prostate.- Testis.- Kidney.- Renal Pelvis and Ureter.- Urinary Bladder.- Urethra.- Adrenal.- Ophthalmic Sites.- Carcinoma of the Eyelid.- Carcinoma of the Conjunctiva.- Malignant Melanoma of the Conjunctiva.- Malignant Melanoma of the Uvea.- Retinoblastoma.- Carcinoma of the Lacrimal Gland.- Sarcoma of the Orbit.- Ocular Adnexal Lymphoma.- Central Nervous System.- Brain and Spinal Cord.- Lymphoid Neoplasms.- Lymphoid Neoplasms.Trade ReviewFrom the reviews of the seventh edition:“Provide a new organ-specific classification that oncologists and other professionals who manage patients with cancer need in order to accurately classify tumours for staging. … a ‘Bible’ for oncologists, pathologists and surgeons, being also useful for all health officers, including general physicians and students, who want to remain updated in oncology. … this is a book that has to be present in all diagnostic imaging departments, as a major support to produce information adequate to the new oncology algorithms.”­­­ (Vincenzo Cuccurullo and Luigi Mansi, European Journal of Nuclear Medicine and Molecular Imaging, Vol. 38, 2011)Table of ContentsGeneral Information on Cancer Staging and End-Results Reporting.- Purposes and Principles of Cancer Staging.- Cancer Survival Analysis.- Head and Neck.- Lip and Oral Cavity.- Pharynx.- Larynx.- Nasal Cavity and Paranasal Sinuses.- Major Salivary Glands.- Thyroid.- Mucosal Melanoma of the Head and Neck.- Digestive System.- Esophagus and Esophagogastric Junction.- Stomach.- Small Intestine.- Colon and Rectum.- Anus.- Gastrointestinal Stromal Tumor.- Neuroendocrine Tumors.- Liver.- Intrahepatic Bile Ducts.- Gallbladder.- Perihilar Bile Ducts.- Distal Bile Duct.- Ampulla of Vater.- Exocrine and Endocrine Pancreas.- Thorax.- Lung.- Pleural Mesothelioma.- Musculoskeletal Sites.- Bone.- Soft Tissue Sarcoma.- Skin.- Cutaneous Squamous Cell Carcinoma and Other Cutaneous Carcinomas.- Merkel Cell Carcinoma.- Melanoma of the Skin.- Breast.- Breast.- Gynecologic Sites.- Vulva.- Vagina.- Cervix Uteri.- Corpus Uteri.- Ovary and Primary Peritoneal Carcinoma.- Fallopian Tube.- Gestational Trophoblastic Tumors.- Genitourinary Sites.- Penis.- Prostate.- Testis.- Kidney.- Renal Pelvis and Ureter.- Urinary Bladder.- Urethra.- Adrenal.- Ophthalmic Sites.- Carcinoma of the Eyelid.- Carcinoma of the Conjunctiva.- Malignant Melanoma of the Conjunctiva.- Malignant Melanoma of the Uvea.- Retinoblastoma.- Carcinoma of the Lacrimal Gland.- Sarcoma of the Orbit.- Ocular Adnexal Lymphoma.- Central Nervous System.- Brain and Spinal Cord.- Lymphoid Neoplasms.- Lymphoid Neoplasms.

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Book SynopsisThere is a general need amongst healthcare professionals for practical advice on the management of patients with bleeding disorders. This book is an essential resource for all those working in the fields of coagulation, hemostasis and thrombosis. It covers the major cases one might encounter in diagnosing, managing and treating hemophilia and hemostasis. It provides a practical and informative guide to the broad range of topics concerning both bleeding and clotting disorders. The book is divided into major chapter sections depending on the type of bleeding disorder it fits into. Each chapter includes a brief overview of the disorder covering: history of the disorder; molecular basis of the disorder; class presentation; genetics; current laboratory tests and monitoring. Cases associated with each disorder are presented alongside practical questions and answers from a wide range of contributors. As practice can vary from center to center, controversial areas are clearly marked Trade Review“Overall, this is an extremely well written book suitable for consultants, trainees and, postgraduates, and is a must for all medical college libraries.” (Indian Journal Medical Research, 1 September 2013) “This is an important book, as there are not many on the management of hemophilia and hemostasis that use a structured, case-based approach.” (Doody’s, 26 July 2013) “On the whole this book is a useful tool for daily practice, particularly for those planning to work outside of a haemophilia comprehensive care centre, where regular exposure to haemophilia is limited.” (Haem Trainee, 1 April 2013)Table of ContentsList of Contributors Foreword SECTION 1: HAEMOPHILIA A AND HAEMOPHILIA B General Overview The hemophilic ankle: an update The haemophilic knee: An update Haemophilia with Inhibitors Inhibitor patient requiring high dose therapy with rVIIa as well as sequential therapy with FEIBA. Prophylactic therapy in a patient with a high titer inhibitor Immune Tolerance Induction Monitoring during ITI FIX inhibitors Severe Hemophilia B with high response inhibitor and anaphylactic reaction to factor IX Inhibitor patient and dental surgery Haemophilic treatment for procedures DVT prophylaxis in patients with hemophilia A undergoing orthopedic surgery Prostate Surgery and Hemophilia Mild Hemophilia and Intraocular Injections Endoscopy/colonoscopy and Hemophilia Dialysis and Hemophilia Circumcision PK Studies prior to Orthopedic Surgery Compartment Syndrome Successful eradication of factor VIII inhibitor in patient with mild Hemophilia A prior to hemipelvectomy for extensive hemophilic pseudotumor Coronary artery disease and hemophilia Valve Replacement and Hemophilia Treatment for other conditions Thyroid biopsy and Hemophilia Atrial Fibrillation and bleeding disorders Chronic Upper GI bleeding and hemophilia Hematuria Other issues in haemophilia care Reproductive Options for Hemophilia A Carriers Mild Hemophilia A with Discrepant FVIII activity levels Compund Diagnoses Hemophilia A with tuberous sclerosis and CNS bleed Familial Risk Assessment for Individuals with Hemophilia A and von Willebrand Disease Hemophilia A and HHT SECTION 2: VON WILLEBRAND DISEASE Management during procedures Type I VWD Tonsillectomy VWD and Dental surgery VWD and GI surgery VWD and Obstetric/Gynecologic Procedures Rare forms of Von Willebrand Disease Type 2A VWD and recurrent GI bleeding Type 2B VWD and Thoracic Surgery Von Willebrand disease 2N SECTION 3: OTHER BLEEDING DISORDERS Prothrombin deficiency Factor V deficiency Factor VII deficiency FX deficiency Factor XI deficiency Factor XIII deficiency Combined factor V and factor VIII deficiency 1, 2 Glanzmann Thrombaesthenia Gardner-Diamond syndrome and VWD Qualitative Platelet Disorder—QPD SECTION 4: ACQUIRED BLEEDING DISORDERS Acquired FVIII inhibitor and B cell neoplasm FVIII inhibitor and lupus inhibitor Acquired VWD A woman with bleeding gums Bleeding after cardiac surgery Bleeding in a dialysis patient A woman with anemia and hematuria Scalp bleeding in an older gentleman Hyperfibrinolysis SECTION 5: THROMBOTIC DISORDERS Heparin induced thrombocytopenia with thrombosis Heparin Skin Necrosis Warfarin skin necrosis Thoracic outlet syndrome 3, 4 Antithrombin Deficiency May-Thurner syndrome Thrombosis in a liver transplant patient Combined thrombophilia Index

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Book SynopsisTo reduce transfusion-related morbidity and mortality, it is recommended that an integrated approach to blood management is employed using all available tools to reduce a patient's exposure to donor blood.Trade Review“This is a valuable guide if you are interested in setting up a blood management program for your organization.” (Doody’s, 15 February 2013)Table of ContentsPreface, vii Preface to the First Edition, viii 1 History and Organization of Blood Management, 1 2 Physiology of Anemia and Oxygen Transport, 9 3 Anemia Therapy I: Erythropoiesis-Stimulating Agents, 21 4 Anemia Therapy II: Hematinics, 36 5 Growth Factors, 51 6 Fluid Management, 67 7 Chemistry of Hemostasis, 81 8 Recombinant Blood Products, 100 9 Artificial Blood, 109 10 Oxygen Therapy, 124 11 Preparation of the Patient for Surgery, 139 12 Iatrogenic Blood Loss, 160 13 Physical Methods of Hemostasis, 173 14 Anesthesia—More than Sleeping, 191 15 Use of Autologous Blood, 201 16 Cell Salvage, 212 17 Blood-Derived Pharmaceuticals, 229 18 Transfusion Medicine, 245 19 Step by Step to an Organized Blood Management Program, 262 20 Law, Ethics, Religion, and Blood Management, 285 Appendix A: Detailed Information, 297 Appendix B: Sources of Information for Blood Management, 305 Appendix C: Program Tools and Forms, 309 Appendix D: Teaching Aids: Research and Projects, 323 Index, 327

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Book SynopsisThis book aims to be a guide to the practice of blood conservation. The first chapter discusses the legal and administrative aspects of bloodless medicine describing the legal principles and practical issues relatd to refusal of transfusion. The second is on balancing the risks and benefits of transfusion includes clinical vignettes of appropriate and inappropriate transfusion. The remainder of the book covers the principles and practice of bloodless medicine, including a chapter on the scientific issues of haemostasis and the investigation of bleeding idsorders. The book concludes with chapters on blood conservation in neonatal and paediatric surgery, the costs associated with blood transfusion and the quest for artifical blood. New chapters will be included to address blood utilization in oncology and geriatric patients.Table of ContentsContributors, ix Preface, xiii 1 History of blood transfusion and patient blood management, 1 Shannon L. Farmer, James Isbister, and Michael F. Leahy 2 The ethical complexities of transfusion-free medicine, surgery and research, 19 Katrina A. Bramstedt 3 Transfusion therapy – Balancing the risks and benefits, 28 Irina Maramica and Ira A. Shulman 4 The physiology of anemia and the threshold for blood transfusion, 61 Senthil G. Krishna, Ahsan Syed, Jason Bryant, and Joseph D. Tobias 5 Blood transfusion in surgery, 83 Sharad Sharma, Lance W Griffin, and Nicolas Jabbour 6 Current view of coagulation system, 102 Yoogoo Kang and Elia Elia 7 Topical hemostatic agents, 143 Fabrizio Di Benedetto and Giuseppe Tarantino 8 Intraoperative strategies for transfusion-free medicine, 158 Joseph D. Tobias 9 Post-operative management in transfusion-free medicine and surgery in the ICU, 207 Jean-Louis Vincent 10 The changing transfusion practice of neonatal and pediatric surgery, 222 Pamela J. Kling and Nicolas Jabbour 11 Current management of anemia in oncology, 247 Shelly Sharma and Sharad Sharma 12 Artificial blood, 271 Aryeh Shander, Mazyar Javidroozi, and Seth Perelman 13 Translational strategies to minimize transfusion requirement in liver surgery and transplantation: Targeting ischemia-reperfusion injury, 289 Reza F. Saidi and S. Kamran Hejazi Kenari 14 Legal and administrative issues related to transfusion-free medicine and surgery programs, 315 Randy Henderson and Nicolas Jabbour 15 Basic principles of bloodless medicine and surgery, 338 Nicolas Jabbour Index, 347

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Book SynopsisHematologic malignancies were the first human cancers to be studied in depth at the molecular level, and recent years have seen important advances in treatment. This comprehensive reference book covers the full range of hematologic malignancies, including all subtypes of leukemias, lymphomas, and plasma cell dyscrasias. Authored by internationally known experts, each chapter emphasizes diagnostic work-up, staging, and therapeutic approaches. Up-to-date hematopathology, treatment, and outcomes data are presented in a way which is directly applicable to patient care. Highly illustrated with color images, graphs, flowcharts and treatment algorithms, the book is perfect for quick clinical reference as well as providing detailed reference lists for further study. With its authoritative and practical focus and visually stimulating presentation, this is a key text for hematology and oncology fellows, physicians, oncology nurses, physician assistants and other healthcare workers in the field oTable of ContentsPreface; 1. Molecular pathology of leukemia Maher Albitar and Amber Donahue; 2. Management of acute myeloid leukemia Alan K. Burnett; 3. Treatment of acute lymphoblastic leukemia (ALL) in adults Ryan Mattison, Sarah Larson and Wendy Stock; 4. Chronic myeloid leukemia Elias Jabour, Hagop M. Kantarjian and Jorge Cortes; 5. Chronic lymphosytic leukemia/small lymphocytic lymphoma Karen W. L. Yee and Susan O'Brien; 6. Myelodysplastic syndromes (MDS) Stefan H. Faderl, Guillermo Garcia-Manerio and Hagop M. Kantarjian; 7. Hairy cell leukemia Darren S. Sigal and Alan Saven; 8. Acute promyelocytic leukemia: pathophysiology and clinical results update Francesco Lo Coco; 9. Myeloproliferative neoplasms Ayalew Tefferi; 10. Monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and multiple myeloma S. Vincent Rajkumar and Suzanne R. Hayman; 11. Amyloidosis and other rare plasma cell dyscrasias Angela Dispenzieri and Suzanne R. Hayman; 12. Waldenstrom's macrogloblinemia/lymphoplasmacytic lymphoma Steven P. Treon and Giampaolo Merlini; 13. WHO classification of lymphomas William W. L. Choi and Wing C. Chan; 14. Molecular pathology of lymphoma David J. Good and Randy D. Gascoyne; 15. International staging and response criteria for lymphomas Bruce D. Cheson; 16. Treatment approach to diffuse large B-cell lymphomas Sonali M. Smith and Julie M. Vose; 17. Mantle cell lymphoma Andre Goy; 18. Follicular lymphomas Francisco J. Hernandez-Ilizaturri and Myron Czuczman; 19. Hodgkin lymphoma: epidemiology, diagnosis, and treatment Andrew M. Evens and Sandra J. Horning; 20. Treatment approaches to MALT/marginal zone lymphoma Stephanie A. Gregory and Parameswaran Venugopal; 21. Peripheral T-cell lymphomas Matthew J. Matasar and Steven Horwitz; 22. Mycosis fungoides and Sezary syndrome Christine Querfeld and Steven T. Rosen; 23. Central nervous system lymphoma Elizabeth R. Gerstner and Tracy T. Batchelor; 24. HIV-related lymphomas Caroline M. Behler and Lawrence D. Kaplan; 25. Lymphoblastic lymphoma Anuj Mahindra and John W. Sweetenham; 26. Burkitt lymphoma Julie M. Vose; Index.

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Book SynopsisThis book has been highly successful ever since it was first published in 1958. Emphasis throughout is placed on diagnosis and management, with particular stress on clinical problems as they confront the practitioner. The new fifth edition has been completely revised and updated to take account of important recent developments such as AIDS, lymphomas and leukaemias, and in order to contain the length, some sections of the book have been condensed.Trade Review"Although this book is clearly orientated to bedside problems, it never fails to explain the usefulness and limitations of laboratory investigations. Such a book is probably needed even more now than it was in 1958 and ... this edition will continue to fill the need admirably ... it remains the best haematology reference for the general physician" British Medical JournalTable of ContentsPreface to Fifth Edition. Preface to First Edition. 1. Formation Blood Cells; Bone Marrow Biopsy. 2. The Red Cell; Basic Aspects of Anaemia. 3. Hypochromic Anaemia: Iron Deficiency and Siberoblastic Anaemia. 4. The Megaloblastic Anaemias. 5. Anaemia in Systemic Disorder; Diagnosis in Normochromic Normocytic Anaemia. 6. Pancytopenia; Aplastic Anaemias. 7. Disorders of Haemoglobin Structure and Synthesis. 8. The Haemolytic Anaemias. 9. White Cells: Neutrophilia and Eosinophilia; Neutropenia and Agranulocytosis; Infectious Monoucleosis. 10. The Leukaemias. 11. Tumours of Lymphiod Tissues; The Paraproteinaemias. 12. Polycythaemia; Myelofibrosis. 13. The Spleen: Hypersplenism and Splenomgaly. 14. The Haemorrhagic Disorder; Capillary and Platelet Defects. 15. Coagulation Disorder. 16. Thrombosis: Clinical Features and Management. 17. Blood Groups; Blood Transfusion; Acquired Immune Deficiency Syndrome. Index.

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Book SynopsisPowerfully involving narrative and incisive detail, clarity and inherent drama: Blood offers in abundance the qualities that define the best popular science writing. Here is the sweeping story of a substance that has been feared, revered, mythologized, and used in magic and medicine from earliest times--a substance that has become the center of a huge, secretive, and often dangerous worldwide commerce.Winner of the Los Angeles Times Book Prize, Blood was described by judges as a gripping page-turner, a significant contribution to the history of medicine and technology and a cautionary tale. Meticulously reported and exhaustively documented.

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Book SynopsisTrade Review"It remains the worldwide standard in laboratory haematology and no haematologist should be without it!" "This is an excellent book for new learners or for experienced practitioners wanting an update/refresher. If you want a basic book covering all aspects of laboratory and clinical hematology, this is the one for you. If you are a student, this is a must have." -Valerie L. Ng, PhD MD (Alameda County Medical Center/Highland Hospital) Doody's Score: 94 - 4 Stars!Table of Contents1 Collection and handling of blood 2 Reference ranges and normal values 3 Basic haematological techniques 4 Preparation and staining methods for blood and bone marrow films 5 Blood cell morphology in health and disease 6 Supplementary techniques including blood parasite diagnosis 7 Bone marrow biopsy 8 Molecular and cytogenetic analysis 9 Iron deficiency anaemia and iron overload 10 Investigation of megaloblastic anaemia: cobalamin, folate and metabolite status 11 Laboratory methods used in the investigation of the haemolytic anaemias 12 Investigation of the hereditary haemolytic anaemias: membrane and enzyme abnormalities 13 Acquired haemolytic anaemias 14 Investigation of variant haemoglobins and thalassaemias 15 Erythrocyte and leucocyte cytochemistry 16 Immunophenotyping by flow cytometry 17 Diagnostic radioisotopes in haematology 18 Investigation of haemostasis 19 Investigation of a thrombotic tendency 20 Laboratory control of anticoagulant, thrombolytic and antiplatelet therapy 21 Blood cell antigens and antibodies: erythrocytes, platelets and neutrophils 22 Laboratory aspects of blood transfusion 23 Approach to the diagnosis and classification of blood cell disorders 24 Laboratory organisation, management and safety 25 Quality assurance 26 Haematology in under-resourced laboratories

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Book SynopsisAccurate analysis of blood gases is vital to give information on a patient's respiratory and circulation state as well as the adequacy of resuscitation. This text guides the reader through the basic principles and a new system of interpretation.Table of ContentsHow to take an arterial blood gas sample; the survival guide to understanding acid-base balance; too much alkali; the survival guide to understanding oxygenation; too little oxygenation; complex situations; special situations; putting it all together; self assessments.

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Book SynopsisProceedings of the First International Symposium on Inhibitory Factors in the Regulation of Hematopoiesis, Paris (France), 26-28 April 1987.

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Book SynopsisThis [is a] concise, jargon-proofed, user-friendly volume."-Journal of the American Medical AssociationTrade ReviewA valuable resource for any cancer caregiver involved with home care... The mundane, the scary, and the technical are covered with practicality and aplomb. All chapters direct the acquisition of skills that lead to successful coping... This [is a] concise, jargon-proofed, user-friendly volume. Journal of the American Medical AssociationTable of ContentsChapter 1. Solving Problems Using the Home Care Guide for CancerChapter 2. Succeeding at CaregivingChapter 3. Fever and InfectionsChapter 4. Tiredness and FatigueChapter 5. Problems with AppetiteChapter 6. Problems with the MouthChapter 7. Nausea and VomitingChapter 8. DiarrheaChapter 9. ConstipationChapter 10. Cancer PainChapter 11. Problems with VeinsChapter 12. Problems with BleedingChapter 13. Skin Problems Chapter 14. Hair LossChapter 15. Sexual ProblemsChapter 16. Maintaining Positive ExperiencesChapter 17. Getting Companionship and Support from Family and FriendsChapter 18. Problems with Getting Information From Medical StaffChapter 19. Getting Help from Community Agencies and Volunteer GroupsChapter 20. Moving Around the House Chapter 21. Coordinating Care From One Treatment Setting to AnotherChapter 22. Coping With AnxietyChapter 23. Coping With DepressionIndex

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Book SynopsisWritten by global experts, this indispensable guide includes over 200 illustrations and essential information in clear tabular formatting, giving hematopathologists rapid access to diagnostic criteria at the microscope. General principles of bone marrow biopsy and aspirate processing are covered, together with the normal and reactive bone marrow, infective, infiltrative and neoplastic diseases. Chapters also guide readers through the use of immunohistochemistry, flow cytometry and molecular diagnosis, whilst extensive referencing provides further reading in specialist and rare topics. Whether working as a generalist, specialist, trainee or resident, this in an essential bench guide for hematopathologists at all levels of experience. The print book comes with access to the text and expandable figures online at Cambridge Core, which can be accessed via the code printed on the inside of the cover.

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