Haematology Books

Book SynopsisAre you constantly exhausted? Does sleep not refresh you? Is your balance not what it was? Do you have tingling or even burning in your fingers and toes? Then your problem may be vitamin B12 deficiency. Your doctor may test you for this but your blood levels look OK so what should you do then? Or you may receive treatment but not feel any better? This book is a guide to the complexities of this deceptively simple problem - how it can be diagnosed, how it can be treated, and how those who have it can cope with the lifelong repercussions. Incorporating the latest research, and the input of the thousands of members of the Pernicious Anaemia Society, this book is both practical and engaging, illustrated with many personal stories that will resonate with sufferers and their friends and families.Table of ContentsIntroduction; Blood, Anaemia, Pernicious Anaemia and Vitamin B12 Deficiency; Causes of vitamin B12 deficiency; Problems with Assessing Vitamin B12 Deficiency; Problems with Diagnosing Pernicious Anaemia; Problems with the Treatment of Pernicious Anaemia; The consequences of pernicious anaemia; Associated health conditions; Current trends and future developments; Ten frequently asked questions

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Book SynopsisTable of Contents1. Effective use of laboratory tests 2. Interpreting laboratory tests 3. The urea and electrolyte (U&E) profile - Sodium - Potassium - Bicarbonate - Chloride - Urea - Creatinine - Estimated glomerular filtration rate (eGFR) - Other tests of kidney function 4. The bone profile - Calcium - Phosphate - Albumin - Alkaline phosphatase (ALP) 5. The liver profile - Bilirubin - Alanine aminotransferase (ALT) - Aspartate aminotransferase (AST) - Gamma glutamyl transpeptidase (GGT) - Alkaline phosphatase (ALP) 6. Blood gas analysis and pH 7. Endocrine testing - Pituitary function - Adrenal function - Thyroid function - Gonadal function - Other hormones 8. Blood proteins 9. Enzymes 10. Glucose and other tests relevant to diabetes mellitus 11. Lipids and other tests relevant to cardiovascular disease 12. Tumour markers 13. Assessing nutrition 14. Heavy metals 15. Therapeutic drug monitoring 16. Poisoning 17. The full blood picture (FBP) - Haemoglobin - White cell count - Platelet count - Red cell indices - Blood film interpretation 18. Tests of coagulation 19. Blood grouping 20. Testing during pregnancy 21. Testing during childhood 22. Metabolic disorders 23. Analysis of body fluids other than blood - Urine - Pleural fluid - Peritoneal fluid - Cerebrospinal fluid - Synovial fluid

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Book SynopsisWritten by national recognized experts and senior fellows at leading research institutions, including the National Institutes of Health, and edited by Drs. Griffin P. Rodgers and Neal S. Young, The Bethesda Handbook of Clinical Hematology, 5th Edition, is a concise, comprehensive handbook designed for everyday clinical use. Organized in a quick-reference, portable format, it covers the clinical information you need to know for the diagnosis and treatment all of blood and bone marrow disorders. Readable and practical, the Bethesda Handbook features numerous tables, algorithms, illustrations, and bulleted lists throughout to help bridge the gap between cutting-edge science and everyday clinical practice. Provides clinically focused, authoritative, and current guidance in this complex area, logically organized by disease category Discusses the pathophysiology, natural history, risk factors, diagnosis, management, and follow-up of common hematological diseases Features new diagnostic and treatment strategies, updated references, and revised information throughout An ideal resource for practitioners at every level of training: students, residents, and fellows on a hematology or oncology service, as well as internists, hospitalists, family practitioners, pediatricians, and nurse practitioners whose practice includes patients with blood diseases

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Book SynopsisHuman Blood Groups is a comprehensive and fully referenced text covering both the scientific and clinical aspects of red cell surface antigens, including: serology, inheritance, biochemistry, molecular genetics, biological functions and clinical significance in transfusion medicine. Since the last edition, seven new blood group systems and over 60 new blood group antigens have been identified. All of the genes representing those systems have now been cloned and sequenced. This essential new information has made the launch of a third edition of Human Blood Groups, now in four colour, particularly timely. This book continues to be an essential reference source for all those who require clinical information on blood groups and antibodies in transfusion medicine and blood banking.Trade Review “It is fascinatingly detailed, and makes a wonderful book for browsing, with many interesting facts, often with historical context to each blood group discovery; but its main audience will be those working within the transfusion laboratory, for whom this will be an invaluable reference.” (Haem Trainee, 1 August 2013) “Get it. If you are involved in blood banking, this is a must-have.” (Doody’s, 14 June 2013)Table of ContentsForeword, vii Preface to the third edition, viii Some abbreviations used, ix 1 Human blood groups: introduction, 1 2 ABO, H, and Lewis systems, 11 3 MNS blood group system, 96 4 P1PK, Globoside, and FORS blood group systems, plus some other related blood groups, 162 5 Rh and RHAG blood group systems, 182 6 Lutheran blood group system, 259 7 Kell and Kx blood group systems, 278 8 Duffy blood group system, 306 9 Kidd blood group system, 325 10 Diego blood group system, 336 11 Yt blood group system, 354 12 Xg blood group system, 359 13 Scianna blood group system, 371 14 Dombrock blood group system, 376 15 Colton blood group system, 384 16 LW blood group system, 391 17 Chido/Rodgers blood group system, 400 18 Gerbich blood group system, 410 19 Cromer blood group system, 427 20 Knops blood group system and the Cost antigens, 439 21 Indian blood group system and the AnWj antigen, 449 22 Ok blood group system, 457 23 Raph blood group system, 461 24 JMH blood group system, 465 25 I and i antigens, and cold agglutination, 469 26 Gill blood group system, 485 27 Junior and Langereis blood group systems, 487 28 Er antigens, 493 29 Low frequency antigens, 495 30 High frequency antigens, including Vel, 500 31 Sid antigen, 505 32 HLA (Human Leucocyte-Associated) Class I antigens on red cells, 512 33 Polyagglutination and cryptantigens, 515 Index, 524

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Book SynopsisThis comprehensive book is written to inform and improve outcomes of patients in need of blood management during surgical procedures. Information is presented in an accessible format, allowing for immediate use in clinical practice.Beginning with an overview of the history of blood transfusions, early chapters present the foundational information needed to comprehend information in later chapters. Nuanced procedures, drugs, and techniques are covered, including new biologicals to assist clotting and blood substitutes. Further discussions focus on potential complications seen in blood transfusions, such as diseases of the coagulation system, pathogen transmissions, and acute lung injuries. Chapters also examine the complexities of treating specific demographics, of which include the geriatric patient and patients suffering from substance abuse. Essentials of Blood Product Management in Anesthesia Practice is an invaluable guide for anesthesiologists, surgeons, trauma physicians, and solid organ transplant providers.Table of ContentsThe History of Blood Transfusions Modern Blood Banking Component Therapy and Whole Blood: Packed Red Blood Cells, Fresh Frozen Plasma, Cryoprecipitate, washed and or radiated red cells The Coagulation System and Clot Stability Fibrinolysis- Tranexamic Acid and Aminocaproic Acid. Hypercoagulation and Thrombotic Disorders: TTP, Factor 5 Leiden, Phospholipid Syndrome, Anti-thrombin 3, hypereosinophils, oxidative stress, cancer. Diseases or Conditions of Platelet Dysfunction The Massive Transfusion Protocol New Biologicals to Assist Clotting- Riastap, Prothrombin Concentrates. Antithrombin3, Fibrogammin and factor13, Fibrosupernatant, Fibrinogen Concentrates, Recombinant Factor 7, DDAVP, Octaplast G., Factor 10A, KCentra Biologicals that Inhibit Clot generation -The Heparins, Factor 10A inhibitors, rivaroxaban, apixaban, dabigatran, Point of Care Testing and Goal Directed Therapy- Thromboelastography, ROTEM, Platelet function analyzer, stat-PT, thrombin generation assays, multi-electro-aggregometry, OHP (Overall hemostatic potential assay), ACT. Complications of Blood Transfusions: TRALI, TACO, Blood type mismatch, infection Diseases of the Coagulation System- Hemophilia, VonWillebrand Disease, Cryoglobulinemia, Inborn Errors of Factor Synthesis Blood Conservation Strategies and Bloodless Surgery- normovolemic hemodilution, cell saver, Bridges to Transfusion when blood is not immediately available. Artificial Blood Preoperative correction of anemia Blood Deployment in Natural Disasters and the Military in Combat Commonly prescribed medications that affect clotting-anti-depressants, NSAIDS, ASA Anesthesia for the severe trauma patient- new evidence from new trials Old blood vs. new blood- Is storage injury a concern? Vascular Endothelial dysfunction and inflammatory states Liberal or restrictive blood transfusions

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Book SynopsisTable of ContentsSection 1: Introduction 1. Introduction to Peripheral Blood Film Examination Section 2: Hematopoiesis 2. Hematopoiesis 3. Erythrocyte Maturation 4. Megakaryocyte Maturation 5. Neutrophil Maturation 6. Monocyte Maturation 7. Eosinophil Maturation 8. Basophil Maturation 9. Lymphocyte Maturation Section 3: Erythrocytes 10. Variations in Size and Color of Erythrocytes 11. Variations in Shape and Distribution of Erythrocytes 12. Inclusions in Erythrocytes 13. Diseases Affecting Erythrocytes Section 4: Leukocytes 14. Nuclear and Cytoplasmic Changes in Leukocytes 15. Acute Myeloid Leukemia 16. Precursor Lymphoid Neoplasms 17. Myeloproliferative Neoplasms 18. Myelodysplastic Syndromes 19. Mature Lymphoproliferative Disorders 20. Morphologic Changes after Myeloid Hematopoietic Growth Factors Section 5: Miscellaneous 21. Microorganisms 22. Miscellaneous Cells 23. Normal Newborn Peripheral Blood Morphology 24. Body Fluids Glossary Appendix: Comparison Tables

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Book SynopsisTrade ReviewAccolades for Previous Editions: Best Book in Medical Science Award --Association of American Publishers Highly Commended Prize (Internal Medicine) --British Medical Association Medical Book Awards "Belongs on the bookshelf of every clinician who assesses patients with platelet disorders" --The Lancet "Landmark" --New England Journal of Medicine "This is a fantastic resource for anyone who treats patients with platelet disorders or is engaged in platelet or megakaryocyte-based research" --British Journal of HaematologyTable of ContentsPART I: Platelet Biology 1. The Evolution of Mammalian Platelets 2. Megakaryocyte Development and Platelet Formation 3. The Structure of Resting and Activated Platelets 4. Platelet Glycobiology and the Control of Platelet Function and Lifespan 5. Platelet Genomics 6. Platelet MicroRNAs 7. The Platelet Transcriptome in Health and Disease 8. The Platelet Proteome 9. Platelet Receptors 10. The Glycoprotein Ib-IX-V Complex 11. GPVI and CLEC-2 12. Integrin aIIbß3 13. Protease-Activated Receptors 14. The Platelet P2 Receptors 15. Platelet Inhibitory Receptors 16. Interactions Between Platelets, Leukocytes, and the Endothelium 17. Inhibition of Platelet Function by the Endothelium 18. Platelet Signal Transduction 19. Platelet Secretion 20. Hemostatic Thrombus Formation in Flowing Blood 21. Interactions Between Platelets and the Coagulation System 22. Platelet-Derived Extracellular Vesicles 23. Regulation of Fibrinolysis by Platelets 24. The Role of Platelets in Angiogenesis 25. Platelet Function in the Newborn PART II: The Role of Platelets in Disease 26. The Role of Platelets in Atherothrombosis 27. The Role of Platelets in Diabetes Mellitus 28. The Role of Platelets in Inflammation 29. The Role of Platelets in Antimicrobial Host Defense 30. The Role of Platelets in Tumor Growth, Metastasis, and Immune Evasion 31. The Role of Platelets in Sickle Cell Disease PART III: Clinical Tests of Platelet Function 32. Platelet Counting 33. Clinical Tests of Platelet Function 34. Platelet Aggregation 35. Flow Cytometry 36. Laboratory Monitoring of Antiplatelet Therapy 37. Platelet Function Testing in Clinical Research Trials PART IV: Disorders of Platelet Number and/or Function 38. The Clinical Approach to Disorders of Platelet Number and Function 39. Immune Thrombocytopenia (ITP) 40. Drug-Induced Thrombocytopenia 41. Heparin-Induced Thrombocytopenia 42. Thrombotic Thrombocytopenic Purpura and Hemolytic-Uremic Syndromes 43. Thrombocytopenia in Pregnancy 44. Thrombocytopenia in the Newborn 45. Alloimmune Thrombocytopenia 46. Inherited Thrombocytopenias 47. Thrombocytosis and Essential Thrombocythemia 48. Inherited Disorders of Platelet Function 49. Acquired Disorders of Platelet Function PART V: Antiplatelet Therapy 50. Aspirin 51. P2Y12 Antagonists 52. aIIbß3 (GPIIb-IIIa) Antagonists 53. PAR-1 Antagonists 54. Phosphodiesterase Inhibitors 55. Novel Antiplatelet Therapies 56. Antiplatelet Drugs in the Management of Coronary Artery Disease 57. Antiplatelet Drugs in the Management of Cerebral Ischemia 58. Antiplatelet Drugs in the Management of Thrombotic/Ischemic Events in Peripheral Artery Disease 59. Antiplatelet Drugs in the Management of Venous Thromboembolism, Cardioembolism, Ventricular Assist Devices, and Pregnancy Complications 60. Antiplatelet Drugs in the Management of Thrombotic/Ischemic Events in Children PART VI: Therapy to Increase Platelet Numbers and/or Function 61. Thrombopoietin Receptor Agonists 62. Desmopressin (DDAVP) 63. Factor VIIa 64. Platelet Transfusion Medicine 65. Therapeutic Platelet-Rich Plasma in Wound Healing 66. Stem Cell-Derived Platelets 67. Gene Therapy for Platelet Disorders

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Book SynopsisThe Oxford Handbook of Clinical Haematology provides core and concise information on the entire spectrum of blood disorders affecting both adults and children. Updated for its fourth edition, it includes all major advances in the specialty, including malignant haematology, haemato-oncology, coagulation, transfusion medicine, and red cell disorders, with a brand new chapter on rare diseases. Practically focused, and specifically designed for ease-of-use, and rapid access to the information you need, this handbook is an indispensable resource on all aspects of haematology for all trainee doctors, nurses, technicians, and research professionals.The handbook is divided into clinical approach and disease-specific areas. The clinical approach section outlines various symptoms and signs in patients with blood disease to enable the reader to formulate a sensible differential diagnosis beofre embarking on investigation and treatment. The disease-specific section is written by four authors whose expertise covers the whole breadth of diseases included in the book. All authors have contributed to national guidelines (e.g. British Committee for Standards in Haematology, BCSH) and are experts in the evidence base that exists for each topic. The Oxford Handbook of Clinical Haematology offers a concise and logical approach to caring for patients with diseases of the blood.Trade ReviewThis new edition follows the tradition of the highly respected Oxford medical handbook series which is a compact, well produced book brimming with knowledge that will help the clinician in a large number of situations. * Dr Harry Brown, glycosmedia.com *Table of Contents1. Clinical approach ; 2. Red cell disorders ; 3. White blood cell abnormalities ; 4. Leukaemia ; 5. Lymphoma ; 6. Myelodysplasia ; 7. Myeloproliferative neoplasms (MPNs) ; 8. Paraproteinaemias ; 9. Haematopoietic stem cell transplantation (SCT) ; 10. Haemostasis and thrombosis ; 11. Immunodeficiency ; 12. Paediatric haematology ; 13. Haematological emergencies ; 14. Supportive care ; 15. Protocols and procedures ; 16. Haematological investigations ; 17. Blood transfusion ; 18. Rare diseases ; A1 Haematology online ; A2 Charts and nomograms ; A3 Normal ranges

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Book SynopsisTable of ContentsIsaacs: Hoffman and Abeloff's Hematology-Oncology Review 1. Cancer biology and Genomics 2. Tumor Immunology 3. Anti-Cancer Therapies SECTION 1: Chemotherapy SECTION 2: Immunotherapy, antibodies, vaccines and pathway inhibitors 4. Clinical Trial Design and Ethics 5. Hereditary Cancer Syndromes HEMATOLOGIC MALIGNANCIES 6. Acute Myeloid Leukemia and Myelodysplastic Syndrome 7. Myeloproliferative Disorders 8. Chronic Lymphocytic Leukemia, Hairy Cell Leukemia, and other Chronic Lymphoproliferative Disorders 9: Hodgkin lymphoma 10. Non-Hodgkin Lymphoma 11. Multiple myeloma and other plasma cell dyscrasias 12. T cell and NK cell neoplasms and other lymphoid malignancies 13. Hematopoeietic Cell Transplantation SOLID TUMOR MALIGNANCIES 14. Breast cancer a: Early Stage Breast Cancer b: Metastatic breast cancer e. Premalignant breast conditions and in situ disease 15. Lung Cancer a: Non-small cell lung cancer b: Small cell lung cancer 16. Other Thoracic Malignancies a: Mesothelioma b: Thymoma and thymic cancer 17. Head and Neck cancer 18 : Esophageal Cancer 19: Gastric cancer 20: Pancreatic cancer 21: Colorectal cancer and Anal Cancer 22: Hepatobiliary cancer 23: Neuroendocrine, small bowel and appendiceal malignancies 24. Prostate cancer 25. Bladder and other urothelial cancers 26. Renal Carcinomas 27. Germ cell tumors 28. Gynecological Malignancies Ovarian Cancer and Fallopian Tube Cancer Cancer of the Cervix, Uterus, Vagina, Vulva and Gestational Choriocarcinoma 29. Melanoma and other skin cancers 30. Bone and soft tissue sarcoma 31.Cancer of unknown primary site 32. . Malignancies of the Central Nervous System a. Primary b. Metastatic NONMALIGNANT HEMATOLOGIC CONDITIONS 33. Coagulation 34. Hematopoietic System 1: Hematopoietic System Disorders RBC or iron 35. Transfusion Medicine SURVIVORSHIP AND END OF LIFE CARE Chapter 36. Supportive Care

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Book SynopsisTrade Review"This comprehensive book is well conceived, well organized, and well presented. This impressive and authoritative work embodies a formal textbook on hemostasis and thrombosis." -Ravi Salgia, MD, PhD (City of Hope) Doody's Score: 100-5 Stars!Table of ContentsKitchens: CONSULTATIVE HEMOSTASIS & THROMBOSIS TOC PART 1: Hemorrhagic Processes 1. Consultative Process 2. An Approach to the Bleeding Patient: Correlation of Clinical Symptoms and Signs with Laboratory Testing 3. Hemophilia A and B 4. Less Common Congenital Disorders of Hemostasis 5. Acquired Coagulation Disorders Due to Inhibitors 6. von Willebrand Disease 7. General Aspects of Thrombocytopenia, Platelet Transfusions, and Thrombopoietic Growth Factors 8. Primary Immune Thrombocytopenia 9. Congenital and Acquired Disorders of Platelet Function and Number 10. Purpura and Other Hematovascular Disorders 11. HHT 12. Disseminated Intravascular Coagulation 13. The Cross-Talk of Inflammation and Coagulation in Infectious Disease and Their Roles in Disseminated Intravascular Coagulation PART 2: Thrombotic Processes 14. Thrombophilia: Clinical and Laboratory Assessment and Management 15. Pediatric Aspects of Thrombophilia 16. Deep Vein Thrombosis, Pulmonary Embolism and Primary Pulmonary Hypertension 17. Venous Thromboses at Unusual Sites 18. The Post Thrombotic Syndrome 19. Thrombocytosis: Essential Thrombocytemia and Reactive Causes 20. Antiphospholipid Syndrome 21. Antiplatelet Treatment in Cardiovascular Medicine 22. Non-Arteriosclerotic Arterial Occlusive Disease 23. Thrombosis and Cancer 24. Thrombotic Thrombocytopenic Purpura 25. Hemostatic Disorders of Complement Activation (PNH and aHUS) - New Chapter 26. Heparin-Induced Thrombocytopenia PART 3: Therapeutic Agents 27. Antithrombotic Agents 28. Blood Component and Pharmacological Agents 29. Therapeutic Apheresis â?" Applications for Hemorrhagic & Thrombotic Disorders 30. Vena Caval Filters PART 4: Issues Specific to Women 31. Thrombotic Risk of Contraceptives and other Hormnal Therapies 32. Bleeding and the Management of Hemorrhagic Disorders in Pregnancy 33. Thrombophilia in Pregnancy PART 5: Special Issues 34. Surgery and Hemostasis 35. Anticoagulation in the Perioperative Period 36. Understanding and Managing the Coagulopathy of Liver Disease 37. Outpatient Anticoagulant Therapy38. Hematologic Interventions for Acute Central Nervous System Disease 39. Pending: Atrial Septal Abnormalties and Cryptogenic Stroke 40. Hemorrhage Control and Thrombosis Following Severe Injury 41. Hemostatic Aspects of Sickle Cell Disease

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Book SynopsisTrade Review"This is a great addition to the current offerings of clinical hematology or hematopathology atlases, filling a specialized and practical niche where these clinical services intersect in real life (e.g., tumor boards).” - ©Doody's Review Service, 2021, Valerie L. Ng, PhD, MD (Alameda County Medical Center/Highland Hospital) Doody's Score: 90 - 4 Stars!Table of ContentsNormal Hemopoiesis and Blood Cell Maturation Growth Factors Hypochromic and Hemolytic Anemias Megaloblastic Anemia Myeloproliferative Neoplasms Mast Cell and Non-Myeloproliferative Myeloid Neoplasms Myelodysplastic Syndromes Acute Myeloid Leukemia Precursor Lymphoid Neoplasms B-Cell Chronic Lymphoid Leukemias Hodgkin Lymphoma Indolent and Aggressive B-Cell Lymphoma Indolent and Aggressive Mature T-Cell and Natural Killer-Cell Lymphomas Myeloma and Related Conditions Childhood Hematopoietic Disorders Posttransplant Lymphoproliferative Disorders and Immunodeficiency Infectious Processes in Blood and Bone Marrow Hemophilia Transfusion Medicine and Cellular Therapy

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Book SynopsisTable of ContentsPart 1. Cytotoxic Chemotherapy 1. Mechanism of Chemotherapy in Cancer Treatment 2. Neutropenic Complications of Chemotherapy 3. Chemotherapy Induced Anemia 4. Cancer Treatment Related Thrombocytopenia 5. Oral Mucositis 6. Gastrointestinal Complications of Chemotherapy 7. Neurological Complications 8. Pulmonary Toxicities of Cytotoxic Chemotherapy 9. Dermatological Complications of Chemotherapy 10. Cardiotoxicities of Chemotherapy 11. Management of Cancer Treatment Infusion Reactions Part 2. Targeted Therapies 12. Mechanism of Targeted Therapies in Cancer Treatment 13. Gastrointestinal Complications 14. Pulmonary Toxicities of Molecular Targeted Therapies 15. Dermatologic Toxicities 16. Cardiotoxicities Part 3. Immunotherapies 17. Mechanism of Immune-Related Adverse Events 18. Endocrine Toxicities 19. Gastrointestinal Toxicities 20. Neurological Complications of Immunotherapy 21. Pulmonary Toxicities 22. Dermatological Complications 23. Immunotherapy-Induced Cardiotoxicities 24. Rheumatological Complications Part 4. Radiation Therapy 25. Mechanisms of Radiation-Related Toxicities 26. Radiation-Induced Mucositis and Esophagitis 27. Radiation Therapy Related Dermatologic Toxicities 28. Pulmonary Toxicity from Radiation Therapy 29. Radiation-Induced Cardiotoxicities

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Book SynopsisTrade Review"The breadth and meticulous detail of this book are a testament to its editors, all of whom are internationally regarded experts in hematology." © The ASCO Post 2023, Ronald PianaTable of ContentsPART I MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY 1. Anatomy and Physiology of the Gene 2. Epigenomics in Hematology 3. Genomic Approaches to Hematology 4. Regulation of Gene Expression in Hematology 5. Genome Editing 6. Signaling Transduction and Metabolomics 7. Protein Architecture: Relationship of Form and Function 8. Pharmacogenomics and Hematologic Diseases PART II CELLULAR BASIS OF HEMATOLOGY 9. Hematopoietic Stem Cell Biology 10. Mitochondria and Hematopoiesis 11. Cytokines, Chemokines, Other Growth Factors, and Their Receptors 12. Role of Chemokines in Leukocyte Trafficking 13. Stem Cell Model of Hematologic Diseases 14. Hematopoietic Microenvironment 15. Cell Adhesion 16. Current Biology of Stem Cell Homing and Mobilization: Dynamic Interactions Between Hematopoietic Stem and Progenitor Cells and Their Surrounding Bone Marrow Microenvironment 17. Control of Cell Division 18. Cell Death 19. Aging and Hematopoiesis PART III IMMUNOLOGIC BASIS OF HEMATOLOGY 20. Dendritic Cell Biology 21. Natural Killer Cell Immunity and Therapy 22. B-Cell Development 23. Complement and Immunoglobulin Biology Leading to Clinical Translation 24. T-Cell Immunity 25. Unmodified Ex Vivo Expanded T Cells 26. Treatment of Hematologic Malignancies with Genetically Modified T Cells PART IV DISORDERS OF HEMATOPOIETIC CELL DEVELOPMENT 27. Biology of Erythropoiesis, Erythroid Differentiation, and Maturation 28. Granulocytopoiesis and Monocytopoiesis 29. Thrombocytopoiesis 30. Inherited Bone Marrow Failure Syndromes 31. Aplastic Anemia 32. Paroxysmal Nocturnal Hemoglobinuria 33. Acquired Disorders of Red Cell, White Cell, and Platelet Production PART V RED BLOOD CELLS 34. Pathobiology of the Human Erythrocyte and Its Hemoglobins 35. Approach to Anemia in the Adult and Child 36. Iron Homeostasis and Its Disorders 37. Disorders of Iron Homeostasis: Iron Deficiency and Overload 38. Anemia of Chronic Inflammation 39. Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias 40. Megaloblastic Anemias 41. Thalassemia Syndromes 42. Pathobiology of Sickle Cell Disease 43. Clinical Aspects of Sickle Cell Disease 44. Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias 45. Red Blood Cell Enzymopathies 46. Red Blood Cell Membrane Disorders 47. Autoimmune Hemolytic Anemia 48. Extrinsic Nonimmune Hemolytic Anemias PART VI NON-MALIGNANT LEUKOCYTES 49. Neutrophilic Leukocytosis, Neutropenia, Monocytosis, and Monocytopenia 50. Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia 51. Disorders of Phagocyte Function 52. Congenital Disorders of Lymphocyte Function 53. Pediatric and Adult Histiocytic Disorders 54. Lysosomal Storage Diseases, Focusing on Gaucher Disease: Perspectives and Principles 55. Epstein-Barr Virus and Associated Lymphoproliferative Conditions PART VII HEMATOLOGIC MALIGNANCIES 56. Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications 57. Conventional and Molecular Cytogenomic Basis of Hematologic Malignancies 58. Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies 59. Pathobiology of Acute Myeloid Leukemia 60. Clinical Manifestations and Treatment of Acute Myeloid Leukemia 61. Myelodysplastic Syndromes 62. Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults 63. Acute Myeloid Leukemia in Children 64. Blastic Plasmacytoid Dendritic Cell Neoplasm 65. Myelodysplastic Syndromes and Myeloproliferative Neoplasms in Children 66. Pathobiology of Acute Lymphoblastic Leukemia 67. Clinical Manifestations and Treatment of Childhood Acute Lymphoblastic Leukemia 68. Acute Lymphoblastic Leukemia in Adults 69. Chronic Myeloid Leukemia 70. The Polycythemias 71. Essential Thrombocythemia 72. Primary Myelofibrosis and Chronic Neutrophilic Leukemia 73. Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes 74. Eosinophilia, Eosinophilic Neoplasms, and the Hypereosinophilic Syndromes 75. Mast Cells and Mastocytosis 76. Chronic Lymphocytic Leukemia 77. Hairy Cell Leukemia 78. The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas 79. Origin of Hodgkin Lymphoma and Therapeutic Targets 80. Hodgkin Lymphoma 81. Origin of Non-Hodgkin Lymphoma and Therapeutic Targets 82. Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma 83. Marginal Zone Lymphomas (Extranodal/MALT, Splenic, and Nodal) 84. Diffuse Large B-Cell Lymphoma of the Central Nervous System 85. High-Grade B-Cell Lymphomas 86. Mantle Cell Lymphoma 87. Virus-Associated Lymphoma 88. Malignant Lymphomas in Childhood 89. T-Cell Lymphomas 90. Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma 91. Multiple Myeloma 92. Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma 93. Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis) PART VIII COMPREHENSIVE CARE OF PATIENTS WITH HEMATOLOGIC MALIGNANCIES 94. Key Considerations for Managing Infections in the Compromised Host 95. Principles of Radiation Therapy for Hematologic Disease 96. Grading and Toxicity Management after Immune Effector Therapy 97. Identification and Management of Checkpoint Inhibition Toxicity 98. Psychosocial Aspects of Hematologic Disorders 99. Pain Management and Antiemetic Therapy in Hematologic Disorders 100. Palliative Care 101. Therapy-related Late Effects of Hematologic Malignancies PART IX TRANSPLANTATION AND OTHER CELL-BASED THERAPIES 102. Practical Aspects of Hematopoietic Stem Cell Harvesting and Mobilization 103. Graft Engineering and Cell Processing 104. Principles of Cell-Based Genetic Therapies 105. Indications, Outcomes, and Donor Selection for Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults 106. Unrelated Donor Hematopoietic Cell Transplantation 107. Haploidentical Hematopoietic Stem Cell Transplantation 108. Cord Blood Transplantation 109. Graft-versus-Host Disease and Graft-versus- Leukemia Responses 110. Supportive Care for the Transplant Patient PART X TRANSFUSION MEDICINE 111. Human Blood Group Antigens and Antibodies 112. Principles of Red Blood Cell Transfusion 113. Clinical Considerations in Platelet Transfusion Therapy 114. Human Leukocyte Antigen and Human Neutrophil Antigen Systems 115. Principles of Plasma and Plasma Derivatives 116. Hemapheresis 117. Transfusion Reactions to Blood and Hematopoietic Stem Cell Therapy Products 118. Transfusion-Transmitted Diseases 119. Pediatric Transfusion Medicine 120. Transfusion and Apheresis Support for Sickle Cell Disease Patients PART XI HEMOSTASIS AND THROMBOSIS 121. Overview of Hemostasis and Thrombosis 122. Blood Vessels 123. Megakaryocyte and Platelet Structure 124. Molecular Basis of Platelet Function 125. Molecular Basis of Blood Coagulation 126. Evaluation of the Patient with Suspected Bleeding Disorders 127. Laboratory Evaluation of Hemostatic and Thrombotic Disorders 128. Acquired Disorders of Platelet Function 129. Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura 130. Thrombocytopenia Caused by Hypersplenism, Platelet Destruction, or Surgery/Hemodilution 131. Heparin-Induced Thrombocytopenia 132. Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndromes 133. Structure, Biology, and Genetics of von Willebrand Factor 134. Hemophilia A and B 135. Rare Coagulation Factor Deficiencies 136. Transfusion Therapy for Coagulation Factor Deficiencies 137. Disseminated Intravascular Coagulation 138. Hypercoagulable States 139. Antiphospholipid Syndrome 140. Venous Thromboembolism 141. Prevention and Treatment of Venous Thromboembolism in Pregnancy 142. Atherothrombosis 143. Antithrombotic Drugs 144. Stroke 145. Acute Coronary Syndromes 146. Peripheral Artery Disease 147. Atrial Fibrillation 148. Bleeding and Clotting Disorders in Pediatrics PART XII CONSULTATIVE HEMATOLOGY 149. Hematologic Changes in Pregnancy 150. Hematologic Manifestations of End-Organ Failure 151. Hematologic Manifestations of Solid Tumors 152. Hematologic Manifestations of HIV/AIDS 153. Hematologic Findings and Consequences of Novel Coronavirus (SARS-CoV-2) Infection 154. Hematologic Aspects of Parasitic Diseases 155. Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis 156. The Spleen and Its Disorders 157. Aging and Hematologic Disorders 158. Onco-cardiology: Focus on Cardiac Complications of Hematologic Treatments 159. Resources for the Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations 2408.e1 Chapter 159 can be found online at Elsevier eBooks for Practicing Clinicians Index

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Book SynopsisTable of Contents1 Laboratory Medicine 2 Statistical Methodologies in Laboratory Medicine 3 Quality Management in the Clinical Laboratory 4 Specimen Collection and Handling 5 Preanalytical Variations and Preexamination Processes 6 Quality Control 7 NEW! Standardization and Harmonization 8 Biological Variations 9 Reference Intervals 10 Evidenced-Based Lab Medicine 11 Biobanking 12 Lab Support of Pharmaceutical, In Vitro Diagnostics and Epidemiologic Studies 13 NEW! Machine Learning and Big Data 14 NEW! Utilization of Laboratory Tests 15 Lab Safety 16 Optical Techniques 17 Electrochemistry and Chemical Sensors 18 Electrophoresis 19 Chromatography 20 Mass Spectrometry 21 Sample Preparation for Mass Spectrometry Applications 22 Mass Spectrometry Applications in Infectious Disease 23 Mass Spectrometry for Small Molecule 24 Proteomics 25 Enzyme and Rate Analysis 26 Immunochemical Techniques 27 Microfabrication and Microfluidics 28 Cytometry 29 Automation in the Clinical Lab 30 Point-of-Care Testing 31 Amino Acids, Peptides, and Proteins 32 Serum Enzymes 33 Tumor Markers 34 Kidney Function Tests 35 Carbohydrates 36 Lipids and Lipoproteins 37 Electrolytes and Blood Gases 38 Hormones 39 Vitamins and Trace Elements 40 Iron Metabolism 41 Porphyrins and Porphyrias 42 Therapeutic Drug Management 43 Clinical Toxicology 44 Toxic Elements 45 Body Fluids 46 Nutrition 47 Diabetes Mellitus 48 Cardiac Function 49 Kidney Disease 50 Disorders of Water, Electrolytes, and Acid-Base Metabolism 51 Liver Disease 52 Gastric, Pancreatic & Intestinal Function 53 Monoamine Producing Tumors 54 Bone and Mineral Metabolism 55 Pituitary Function 56 Adrenal Cortex 57 Thyroid Disorders 58 Reproductive Endocrinology 59 Pregnancy and its Disorders 60 Newborn Screening and Inborn Errors of Metabolism (Small Molecules) 61 Newborn Screening and Inborn Errors of Metabolism (Large Molecules) 62 Principles of Molecular Biology 63 Nucleic Acid Isolation 64 Nucleic Acid Techniques 65 Genomes, Variants, and Massively Paralleled Methods 66 NEW! Clinical Genome Sequencing 67 Molecular Microbiology 68 Genetics 69 Solid Tumors 70 NEW! Hematopathology 71 Circulating Tumor Cells and Circulating Nucleic Acids in Oncology 72 Circulating Nucleic Acids for Prenatal Diagnostics 73 Pharmacogenetics 74 Hemostasis 75 NEW! Hemoglobin and Hemoglobinopathies 76 Automated Hematology 77 Red Blood Cell Morphology and Indices with Clinical Chemistry Interface 78 NEW! White Blood Cell Morphology 79 NEW! Platelets 80 NEW! Enzymes of the RBC 81 NEW! Overview of Infectious Disease 82 NEW! The Role of the Clinical Laboratory in Infection Prevention and Antimicrobial Stewardship 83 Bacteriology 84 Antimicrobial Susceptibility Testing 85 Mycobacteriology 86 Mycology 87 Parasitology 88 Virology 89 Blood Groups and Pretransfusion Testing 90 Blood Components, Products Modifications, and Blood Donor Screening 91 NEW! Indications for Transfusion: RBCs, platelets, plasma, and cryoprecipitate 92 NEW! Transfusion reactions/adverse events associated with transfusion 93 NEW! Allergy Testing 94 NEW! Immunogenicity of Biologics 95 NEW! Systemic Autoimmune Disease (ANA testing, RF, CCP, antibodies, etc. 96 NEW! Primary and secondary immunodeficiencies 97 NEW! Transplant 98 NEW! Immunogenetics Appendix Reference Information for the Clinical Laboratory

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Book SynopsisTable of ContentsTop 100 Secrets Diagnostic Approach to Anemia in Childhood Disorders of Hemoglobin, Normal Development Sickle Cell Syndromes Thalassemia Syndromes Anemia Secondary to Enzyme Deficiencies Anemia Secondary to Membrane Disorders Autoimmune Hemolytic Anemia Anemia Secondary to Nutritional Deficiencies Neonatal Anemia Normal Hemostasis Neonatal Hemostasis Disorders of Coagulation Disorders of Platelets Disorders of the Immune System Disorders of Granulocyte Function and Granulopoiesis Storage Disorders Hematologic Manifestations of Systemic Disease Bone Marrow Failure Syndromes Principles and Practice of Childhood Cancer Genetics, Molecular Genetrics Principles of Chemotherapy Principles of Surgical Oncology Principles of Radition Oncology for Pediatric Malignancy Acute Lymphoblastic Leukemia Acute Myelogenous Leukemia Myeloproliferative Disorders Non-Hodgkin's Lymphoma Hodgkin's Disease Lymphoproliferative Disorders Langerhans Cell Histiocytosis Tumors of the Central Nervous System Retinoblastoma Hepatic Tumors Wilms' Tumor Neuroblastoma Soft Tissue Sarcomas Bone Tumors Germ Cell Tumors Oncologic Emergencies Bone Marrow Transplant/PBSC Principles of Molecular Diagnostics and Therapeutic Supportive Care Late Effects of Childhood Cancer Psycho-social Aspects of Care of the child with Cancer Palliative Care Management of the Dying Child

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Book SynopsisTrade Review"This book has grown since the first edition to maintain its standing as a comprehensive text (including 14 new chapters). Overall, this book provides all the essential knowledge on splenic pathology in one single resource. It is ideal for daily use as a reference but is also an excellent training resource for learners." ©Doody's Review Service, 2022, Anna B Owczarczyk, MD, PHD (University of Michigan Medical School) Doody's Score: 5 Stars!Table of ContentsSECTION 1: HISTOLOGY, FUNCTION, AND DEVELOPMENT OF SPLEEN NORMAL HISTOLOGY 4 Introduction to Spleen Mohammad A. Vasef, MD and Jeremy C. Wallentine, MD 12 Imaging of Splenic Disorders Mohammad A. Vasef, MD 18 Handling, Processing, and Gross Pathology of Spleen Mohammad A. Vasef, MD 26 Fine-Needle Aspiration and Core Biopsy of Spleen Mohammad A. Vasef, MD 32 Immunohistochemistry of Spleen Aaron Auerbach, MD, MPH 40 Flow Cytometry Nadine Aguilera, MD 46 Molecular Techniques Nadine Aguilera, MD SECTION 2: NONNEOPLASTIC SPLENIC DISORDERS LYMPHOID HYPERPLASIA 54 Florid Follicular Hyperplasia Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH 56 Autoimmune Disease Nadine Aguilera, MD 62 HIV in Spleen Nadine Aguilera, MD 68 Castleman Disease Nadine Aguilera, MD 70 Marginal Zone Hyperplasia Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH GRANULOMATOUS LESIONS/DISORDERS 72 Lipogranulomas Jeffrey Vos, MD 78 Sarcoidosis Ellina Hall, DO and Aaron Auerbach, MD, MPH 82 Chronic Granulomatous Disease Aaron Auerbach, MD, MPH INFECTIONS 86 Mycobacteriosis Nadine Aguilera, MD 90 Selected Bacterial Infections Aaron Auerbach, MD, MPH 94 Candidiasis Aaron Auerbach, MD, MPH 96 Histoplasmosis Nadine Aguilera, MD 98 Cryptococcosis Nadine Aguilera, MD 100 Coccidioidomycosis Aaron Auerbach, MD, MPH 104 Pneumocystosis Aaron Auerbach, MD, MPH 108 Infectious Mononucleosis Nadine Aguilera, MD 112 Cytomegalovirus Infection Nadine Aguilera, MD 114 Herpes Simplex Virus Infection Aaron Auerbach, MD, MPH and Nadine Aguilera, MD 116 Echinococcosis Aaron Auerbach, MD, MPH 120 Malaria Nadine Aguilera, MD NONINFECTIOUS CYSTS 122 Epithelial Cyst Ellina Hall, DO and Aaron Auerbach, MD, MPH 124 False Cyst Ellina Hall, DO and Aaron Auerbach, MD, MPH NONNEOPLASTIC VASCULAR PROCESSES 126 Chronic Passive Congestion Ellina Hall, DO and Aaron Auerbach, MD, MPH 128 Infarct Jeffrey Vos, MD 136 Peliosis Ellina Hall, DO and Aaron Auerbach, MD, MPH 138 Sclerosing Angiomatoid Nodular Transformation Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD RED CELL DISORDERS 144 Sickle Cell Disease Aaron Auerbach, MD, MPH and Ellina Hall, DO 146 Thalassemia Nadine Aguilera, MD and Aaron Auerbach, MD, MPH 150 Hereditary Spherocytosis Nadine Aguilera, MD 152 Thrombotic Thrombocytopenic Purpura Aaron Auerbach, MD, MPH MISCELLANEOUS LESIONS/DISORDERS 158 Heterotaxy Syndromes Aaron Auerbach, MD, MPH 160 Congenital Splenic Abnormalities Nadine Aguilera, MD 164 Extramedullary Hematopoiesis Ellina Hall, DO and Aaron Auerbach, MD, MPH 166 Gamna-Gandy Bodies Nadine Aguilera, MD 168 Hemophagocytic Lymphohistiocytosis Nadine Aguilera, MD 174 Immune Thrombocytopenic Purpura Ellina Hall, DO and Aaron Auerbach, MD, MPH 178 Niemann-Pick Disease Meenakshi A. Nandedkar, MD and Nadine Aguilera, MD 184 Gaucher Disease Meenakshi A. Nandedkar, MD and Nadine Aguilera, MD 188 Sea-Blue (Ceroid) Histiocytosis Mohammad A. Vasef, MD 192 Gangliosidosis Lysosomal Disorder Mohammad A. Vasef, MD 194 Therapy Effect on Spleen Aaron Auerbach, MD, MPH 202 Traumatic and Nontraumatic Splenic Injuries Mohammad A. Vasef, MD SECTION 3: NEOPLASTIC SPLENIC DISORDERS BENIGN MESENCHYMAL LESIONS 208 Introduction to Vascular Lesions Nadine Aguilera, MD 210 Hemangioma Nadine Aguilera, MD 218 Lymphangioma Nadine Aguilera, MD 222 Littoral Cell Angioma Nadine Aguilera, MD 228 Inflammatory Pseudotumor Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 236 Postchemotherapy Histiocyte-Rich Pseudotumor of Spleen Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 242 Splenic Hamartoma Nadine Aguilera, MD 246 Myelolipoma Aaron Auerbach, MD, MPH MALIGNANT OR POTENTIALLY MALIGNANT MESENCHYMAL LESIONS 248 Angiosarcoma Nadine Aguilera, MD 256 Hemangioendothelioma Nadine Aguilera, MD 258 Kaposi Sarcoma Nadine Aguilera, MD 260 Leiomyosarcoma Aaron Auerbach, MD, MPH 266 Gastrointestinal Stromal Tumor Aaron Auerbach, MD, MPH 272 Follicular Dendritic Cell Sarcoma Aaron Auerbach, MD, MPH 280 Inflammatory Pseudotumor-Like Follicular Dendritic Cell Sarcoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 286 Langerhans Cell Histiocytosis Guanghua Wang, MD 292 Histiocytic Sarcoma Nadine Aguilera, MD LYMPHOMA 300 Introduction to Lymphoma Mohammad A. Vasef, MD 310 Splenic Marginal Zone Lymphoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 318 Hairy Cell Leukemia Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 326 Hairy Cell Leukemia Variant Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 334 Lymphoplasmacytic Lymphoma Aaron Auerbach, MD, MPH 342 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 350 Follicular Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 358 Mantle Cell Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 366 Leukemic Nonnodal Mantle Cell Lymphoma Mohammad A. Vasef, MD 370 Splenic Diffuse Red Pulp B-Cell Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 376 B-Cell Prolymphocytic Leukemia Aaron Auerbach, MD, MPH and Nadine Aguilera, MD 378 Diffuse Large B-Cell Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 384 Fibrin-Associated Large B-Cell Lymphoma in Splenic False Cyst Mohammad A. Vasef, MD 390 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Jeffrey Vos, MD 398 Burkitt Lymphoma Aaron Auerbach, MD, MPH 406 Classic Hodgkin Lymphoma Jeffrey Vos, MD 416 Nodular Lymphocyte-Predominant Hodgkin Lymphoma Aaron Auerbach, MD, MPH 426 Peripheral T-Cell Lymphoma, Unspecified Mohammad A. Vasef, MD 432 Hepatosplenic T-Cell Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 440 T-Cell Prolymphocytic Leukemia Mohammad A. Vasef, MD 448 T-Cell Large Granular Lymphocytic Leukemia Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 456 Aggressive NK-Cell Leukemia Aaron Auerbach, MD, MPH 462 Transformation of Splenic Disorders Nadine Aguilera, MD LEUKEMIA 466 Acute Myeloid Leukemia Nadine Aguilera, MD 474 Lymphoblastic Leukemia/Lymphoma Nadine Aguilera, MD CHRONIC MYELOPROLIFERATIVE NEOPLASMS/MYELODYSPLASTIC SYNDROMES 480 Myeloproliferative Neoplasm Overview Nadine Aguilera, MD 482 Chronic Myeloid Leukemia, BCR::ABL1 Positive Nadine Aguilera, MD 488 Essential Thrombocythemia Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH 492 Polycythemia Vera Guanghua Wang, MD 496 Primary Myelofibrosis Jeffrey Vos, MD 506 Mastocytosis Mohammad A. Vasef, MD 514 Chronic Myelomonocytic Leukemia Mohammad A. Vasef, MD PLASMA CELL-ASSOCIATED DISORDERS 520 Amyloidosis Nadine Aguilera, MD 526 Heavy Chain Disease Aaron Auerbach, MD, MPH 530 Plasma Cell Myeloma/Plasmacytoma Nadine Aguilera, MD and Aaron Auerbach, MD, MPH METASTASIS 534 Metastatic Tumors Ellina Hall, DO and Aaron Auerbach, MD, MPH

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Book SynopsisTable of ContentsSECTION 1 HEMATOLOGY 1 Innovations in Screening and Management of Neonatal Hyperbilirubinemia 2 The Pivotal Role of Macrophages in the Pathogenesis of Necrotizing Enterocolitis 3 Nucleated Red Blood Cells in Neonatal Medicine 4 Age-Appropriate Biology of Neonatal Neutrophils 5 New Erythrocyte Diagnostic Parameters in Neonatal Medicine 6 Neonatal Iron Homeostasis 7 Risk Factors for Iron Deficiency in Neonates 8 Using Targeted Genetic Panels to Find the Causes of Neonatal Hemolytic Anemia SECTION 2 TRANSFUSION MEDICINE 9 Erythropoietin and Darbepoetin Use in the NICU 10 NICU Transfusion Guidelines and Strategies to Minimize Transfusions 11 Neonatal Blood Banking and Transfusion: Current Questions and Controversies 12 Recent Advances in NICU Platelet Transfusions 13 Novel Approaches to Identify NICU Patients Who Would Benefit From Platelet Transfusions 14 Evidence-Based Guidelines for Administering Fresh Frozen Plasma in the NICU 15 Pathophysiologic Importance of Platelets in Neonatal Necrotizing Enterocolitis Index

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Book SynopsisTable of ContentsPart 1: The Practice of Phlebotomy 1. Introduction to Phlebotomy 2. Anatomy and Physiology 3. Infectious Diseases and Their Prevention 4. Medical Terminology 5. Equipment 6. Proper Procedures for Venipuncture 7. Special Collection Procedures 8. Neonatal and Geriatric Procedures and Considerations 9. Considerations and Complications of Phlebotomy 10. The Versatile Phlebotomist and Point-of-Care Testing Part 2: Professional Issues 11. Interpersonal Communication and Professionalism 12. Phlebotomy Department Management 13. Total Quality in Phlebotomy Service 14. Medical-Legal Issues and Health Law Procedures Appendix A: Answers to Chapter Review Questions Appendix B: Practice Examination for Certification Appendix C: Helpful Spanish Terms and Phrases Glossary Index

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Book SynopsisGeneral Information on Cancer Staging and End-Results Reporting.- Purposes and Principles of Cancer Staging.- Cancer Survival Analysis.- Head and Neck.- Lip and Oral Cavity.- Pharynx.- Larynx.- Nasal Cavity and Paranasal Sinuses.- Major Salivary Glands.- Thyroid.- Mucosal Melanoma of the Head and Neck.- Digestive System.- Esophagus and Esophagogastric Junction.- Stomach.- Small Intestine.- Colon and Rectum.- Anus.- Gastrointestinal Stromal Tumor.- Neuroendocrine Tumors.- Liver.- Intrahepatic Bile Ducts.- Gallbladder.- Perihilar Bile Ducts.- Distal Bile Duct.- Ampulla of Vater.- Exocrine and Endocrine Pancreas.- Thorax.- Lung.- Pleural Mesothelioma.- Musculoskeletal Sites.- Bone.- Soft Tissue Sarcoma.- Skin.- Cutaneous Squamous Cell Carcinoma and Other Cutaneous Carcinomas.- Merkel Cell Carcinoma.- Melanoma of the Skin.- Breast.- Breast.- Gynecologic Sites.- Vulva.- Vagina.- Cervix Uteri.- Corpus Uteri.- Ovary and Primary Peritoneal Carcinoma.- Fallopian Tube.- Gestational Trophoblastic Tumors.- Genitourinary Sites.- Penis.- Prostate.- Testis.- Kidney.- Renal Pelvis and Ureter.- Urinary Bladder.- Urethra.- Adrenal.- Ophthalmic Sites.- Carcinoma of the Eyelid.- Carcinoma of the Conjunctiva.- Malignant Melanoma of the Conjunctiva.- Malignant Melanoma of the Uvea.- Retinoblastoma.- Carcinoma of the Lacrimal Gland.- Sarcoma of the Orbit.- Ocular Adnexal Lymphoma.- Central Nervous System.- Brain and Spinal Cord.- Lymphoid Neoplasms.- Lymphoid Neoplasms.Trade ReviewFrom the reviews of the seventh edition:“Provide a new organ-specific classification that oncologists and other professionals who manage patients with cancer need in order to accurately classify tumours for staging. … a ‘Bible’ for oncologists, pathologists and surgeons, being also useful for all health officers, including general physicians and students, who want to remain updated in oncology. … this is a book that has to be present in all diagnostic imaging departments, as a major support to produce information adequate to the new oncology algorithms.”­­­ (Vincenzo Cuccurullo and Luigi Mansi, European Journal of Nuclear Medicine and Molecular Imaging, Vol. 38, 2011)Table of ContentsGeneral Information on Cancer Staging and End-Results Reporting.- Purposes and Principles of Cancer Staging.- Cancer Survival Analysis.- Head and Neck.- Lip and Oral Cavity.- Pharynx.- Larynx.- Nasal Cavity and Paranasal Sinuses.- Major Salivary Glands.- Thyroid.- Mucosal Melanoma of the Head and Neck.- Digestive System.- Esophagus and Esophagogastric Junction.- Stomach.- Small Intestine.- Colon and Rectum.- Anus.- Gastrointestinal Stromal Tumor.- Neuroendocrine Tumors.- Liver.- Intrahepatic Bile Ducts.- Gallbladder.- Perihilar Bile Ducts.- Distal Bile Duct.- Ampulla of Vater.- Exocrine and Endocrine Pancreas.- Thorax.- Lung.- Pleural Mesothelioma.- Musculoskeletal Sites.- Bone.- Soft Tissue Sarcoma.- Skin.- Cutaneous Squamous Cell Carcinoma and Other Cutaneous Carcinomas.- Merkel Cell Carcinoma.- Melanoma of the Skin.- Breast.- Breast.- Gynecologic Sites.- Vulva.- Vagina.- Cervix Uteri.- Corpus Uteri.- Ovary and Primary Peritoneal Carcinoma.- Fallopian Tube.- Gestational Trophoblastic Tumors.- Genitourinary Sites.- Penis.- Prostate.- Testis.- Kidney.- Renal Pelvis and Ureter.- Urinary Bladder.- Urethra.- Adrenal.- Ophthalmic Sites.- Carcinoma of the Eyelid.- Carcinoma of the Conjunctiva.- Malignant Melanoma of the Conjunctiva.- Malignant Melanoma of the Uvea.- Retinoblastoma.- Carcinoma of the Lacrimal Gland.- Sarcoma of the Orbit.- Ocular Adnexal Lymphoma.- Central Nervous System.- Brain and Spinal Cord.- Lymphoid Neoplasms.- Lymphoid Neoplasms.

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Book SynopsisThere is a general need amongst healthcare professionals for practical advice on the management of patients with bleeding disorders. This book is an essential resource for all those working in the fields of coagulation, hemostasis and thrombosis. It covers the major cases one might encounter in diagnosing, managing and treating hemophilia and hemostasis. It provides a practical and informative guide to the broad range of topics concerning both bleeding and clotting disorders. The book is divided into major chapter sections depending on the type of bleeding disorder it fits into. Each chapter includes a brief overview of the disorder covering: history of the disorder; molecular basis of the disorder; class presentation; genetics; current laboratory tests and monitoring. Cases associated with each disorder are presented alongside practical questions and answers from a wide range of contributors. As practice can vary from center to center, controversial areas are clearly marked Trade Review“Overall, this is an extremely well written book suitable for consultants, trainees and, postgraduates, and is a must for all medical college libraries.” (Indian Journal Medical Research, 1 September 2013) “This is an important book, as there are not many on the management of hemophilia and hemostasis that use a structured, case-based approach.” (Doody’s, 26 July 2013) “On the whole this book is a useful tool for daily practice, particularly for those planning to work outside of a haemophilia comprehensive care centre, where regular exposure to haemophilia is limited.” (Haem Trainee, 1 April 2013)Table of ContentsList of Contributors Foreword SECTION 1: HAEMOPHILIA A AND HAEMOPHILIA B General Overview The hemophilic ankle: an update The haemophilic knee: An update Haemophilia with Inhibitors Inhibitor patient requiring high dose therapy with rVIIa as well as sequential therapy with FEIBA. Prophylactic therapy in a patient with a high titer inhibitor Immune Tolerance Induction Monitoring during ITI FIX inhibitors Severe Hemophilia B with high response inhibitor and anaphylactic reaction to factor IX Inhibitor patient and dental surgery Haemophilic treatment for procedures DVT prophylaxis in patients with hemophilia A undergoing orthopedic surgery Prostate Surgery and Hemophilia Mild Hemophilia and Intraocular Injections Endoscopy/colonoscopy and Hemophilia Dialysis and Hemophilia Circumcision PK Studies prior to Orthopedic Surgery Compartment Syndrome Successful eradication of factor VIII inhibitor in patient with mild Hemophilia A prior to hemipelvectomy for extensive hemophilic pseudotumor Coronary artery disease and hemophilia Valve Replacement and Hemophilia Treatment for other conditions Thyroid biopsy and Hemophilia Atrial Fibrillation and bleeding disorders Chronic Upper GI bleeding and hemophilia Hematuria Other issues in haemophilia care Reproductive Options for Hemophilia A Carriers Mild Hemophilia A with Discrepant FVIII activity levels Compund Diagnoses Hemophilia A with tuberous sclerosis and CNS bleed Familial Risk Assessment for Individuals with Hemophilia A and von Willebrand Disease Hemophilia A and HHT SECTION 2: VON WILLEBRAND DISEASE Management during procedures Type I VWD Tonsillectomy VWD and Dental surgery VWD and GI surgery VWD and Obstetric/Gynecologic Procedures Rare forms of Von Willebrand Disease Type 2A VWD and recurrent GI bleeding Type 2B VWD and Thoracic Surgery Von Willebrand disease 2N SECTION 3: OTHER BLEEDING DISORDERS Prothrombin deficiency Factor V deficiency Factor VII deficiency FX deficiency Factor XI deficiency Factor XIII deficiency Combined factor V and factor VIII deficiency 1, 2 Glanzmann Thrombaesthenia Gardner-Diamond syndrome and VWD Qualitative Platelet Disorder—QPD SECTION 4: ACQUIRED BLEEDING DISORDERS Acquired FVIII inhibitor and B cell neoplasm FVIII inhibitor and lupus inhibitor Acquired VWD A woman with bleeding gums Bleeding after cardiac surgery Bleeding in a dialysis patient A woman with anemia and hematuria Scalp bleeding in an older gentleman Hyperfibrinolysis SECTION 5: THROMBOTIC DISORDERS Heparin induced thrombocytopenia with thrombosis Heparin Skin Necrosis Warfarin skin necrosis Thoracic outlet syndrome 3, 4 Antithrombin Deficiency May-Thurner syndrome Thrombosis in a liver transplant patient Combined thrombophilia Index

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Book SynopsisTo reduce transfusion-related morbidity and mortality, it is recommended that an integrated approach to blood management is employed using all available tools to reduce a patient's exposure to donor blood.Trade Review“This is a valuable guide if you are interested in setting up a blood management program for your organization.” (Doody’s, 15 February 2013)Table of ContentsPreface, vii Preface to the First Edition, viii 1 History and Organization of Blood Management, 1 2 Physiology of Anemia and Oxygen Transport, 9 3 Anemia Therapy I: Erythropoiesis-Stimulating Agents, 21 4 Anemia Therapy II: Hematinics, 36 5 Growth Factors, 51 6 Fluid Management, 67 7 Chemistry of Hemostasis, 81 8 Recombinant Blood Products, 100 9 Artificial Blood, 109 10 Oxygen Therapy, 124 11 Preparation of the Patient for Surgery, 139 12 Iatrogenic Blood Loss, 160 13 Physical Methods of Hemostasis, 173 14 Anesthesia—More than Sleeping, 191 15 Use of Autologous Blood, 201 16 Cell Salvage, 212 17 Blood-Derived Pharmaceuticals, 229 18 Transfusion Medicine, 245 19 Step by Step to an Organized Blood Management Program, 262 20 Law, Ethics, Religion, and Blood Management, 285 Appendix A: Detailed Information, 297 Appendix B: Sources of Information for Blood Management, 305 Appendix C: Program Tools and Forms, 309 Appendix D: Teaching Aids: Research and Projects, 323 Index, 327

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Book SynopsisThis book aims to be a guide to the practice of blood conservation. The first chapter discusses the legal and administrative aspects of bloodless medicine describing the legal principles and practical issues relatd to refusal of transfusion. The second is on balancing the risks and benefits of transfusion includes clinical vignettes of appropriate and inappropriate transfusion. The remainder of the book covers the principles and practice of bloodless medicine, including a chapter on the scientific issues of haemostasis and the investigation of bleeding idsorders. The book concludes with chapters on blood conservation in neonatal and paediatric surgery, the costs associated with blood transfusion and the quest for artifical blood. New chapters will be included to address blood utilization in oncology and geriatric patients.Table of ContentsContributors, ix Preface, xiii 1 History of blood transfusion and patient blood management, 1 Shannon L. Farmer, James Isbister, and Michael F. Leahy 2 The ethical complexities of transfusion-free medicine, surgery and research, 19 Katrina A. Bramstedt 3 Transfusion therapy – Balancing the risks and benefits, 28 Irina Maramica and Ira A. Shulman 4 The physiology of anemia and the threshold for blood transfusion, 61 Senthil G. Krishna, Ahsan Syed, Jason Bryant, and Joseph D. Tobias 5 Blood transfusion in surgery, 83 Sharad Sharma, Lance W Griffin, and Nicolas Jabbour 6 Current view of coagulation system, 102 Yoogoo Kang and Elia Elia 7 Topical hemostatic agents, 143 Fabrizio Di Benedetto and Giuseppe Tarantino 8 Intraoperative strategies for transfusion-free medicine, 158 Joseph D. Tobias 9 Post-operative management in transfusion-free medicine and surgery in the ICU, 207 Jean-Louis Vincent 10 The changing transfusion practice of neonatal and pediatric surgery, 222 Pamela J. Kling and Nicolas Jabbour 11 Current management of anemia in oncology, 247 Shelly Sharma and Sharad Sharma 12 Artificial blood, 271 Aryeh Shander, Mazyar Javidroozi, and Seth Perelman 13 Translational strategies to minimize transfusion requirement in liver surgery and transplantation: Targeting ischemia-reperfusion injury, 289 Reza F. Saidi and S. Kamran Hejazi Kenari 14 Legal and administrative issues related to transfusion-free medicine and surgery programs, 315 Randy Henderson and Nicolas Jabbour 15 Basic principles of bloodless medicine and surgery, 338 Nicolas Jabbour Index, 347

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Book SynopsisHematologic malignancies were the first human cancers to be studied in depth at the molecular level, and recent years have seen important advances in treatment. This comprehensive reference book covers the full range of hematologic malignancies, including all subtypes of leukemias, lymphomas, and plasma cell dyscrasias. Authored by internationally known experts, each chapter emphasizes diagnostic work-up, staging, and therapeutic approaches. Up-to-date hematopathology, treatment, and outcomes data are presented in a way which is directly applicable to patient care. Highly illustrated with color images, graphs, flowcharts and treatment algorithms, the book is perfect for quick clinical reference as well as providing detailed reference lists for further study. With its authoritative and practical focus and visually stimulating presentation, this is a key text for hematology and oncology fellows, physicians, oncology nurses, physician assistants and other healthcare workers in the field oTable of ContentsPreface; 1. Molecular pathology of leukemia Maher Albitar and Amber Donahue; 2. Management of acute myeloid leukemia Alan K. Burnett; 3. Treatment of acute lymphoblastic leukemia (ALL) in adults Ryan Mattison, Sarah Larson and Wendy Stock; 4. Chronic myeloid leukemia Elias Jabour, Hagop M. Kantarjian and Jorge Cortes; 5. Chronic lymphosytic leukemia/small lymphocytic lymphoma Karen W. L. Yee and Susan O'Brien; 6. Myelodysplastic syndromes (MDS) Stefan H. Faderl, Guillermo Garcia-Manerio and Hagop M. Kantarjian; 7. Hairy cell leukemia Darren S. Sigal and Alan Saven; 8. Acute promyelocytic leukemia: pathophysiology and clinical results update Francesco Lo Coco; 9. Myeloproliferative neoplasms Ayalew Tefferi; 10. Monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and multiple myeloma S. Vincent Rajkumar and Suzanne R. Hayman; 11. Amyloidosis and other rare plasma cell dyscrasias Angela Dispenzieri and Suzanne R. Hayman; 12. Waldenstrom's macrogloblinemia/lymphoplasmacytic lymphoma Steven P. Treon and Giampaolo Merlini; 13. WHO classification of lymphomas William W. L. Choi and Wing C. Chan; 14. Molecular pathology of lymphoma David J. Good and Randy D. Gascoyne; 15. International staging and response criteria for lymphomas Bruce D. Cheson; 16. Treatment approach to diffuse large B-cell lymphomas Sonali M. Smith and Julie M. Vose; 17. Mantle cell lymphoma Andre Goy; 18. Follicular lymphomas Francisco J. Hernandez-Ilizaturri and Myron Czuczman; 19. Hodgkin lymphoma: epidemiology, diagnosis, and treatment Andrew M. Evens and Sandra J. Horning; 20. Treatment approaches to MALT/marginal zone lymphoma Stephanie A. Gregory and Parameswaran Venugopal; 21. Peripheral T-cell lymphomas Matthew J. Matasar and Steven Horwitz; 22. Mycosis fungoides and Sezary syndrome Christine Querfeld and Steven T. Rosen; 23. Central nervous system lymphoma Elizabeth R. Gerstner and Tracy T. Batchelor; 24. HIV-related lymphomas Caroline M. Behler and Lawrence D. Kaplan; 25. Lymphoblastic lymphoma Anuj Mahindra and John W. Sweetenham; 26. Burkitt lymphoma Julie M. Vose; Index.

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Book SynopsisThis book has been highly successful ever since it was first published in 1958. Emphasis throughout is placed on diagnosis and management, with particular stress on clinical problems as they confront the practitioner. The new fifth edition has been completely revised and updated to take account of important recent developments such as AIDS, lymphomas and leukaemias, and in order to contain the length, some sections of the book have been condensed.Trade Review"Although this book is clearly orientated to bedside problems, it never fails to explain the usefulness and limitations of laboratory investigations. Such a book is probably needed even more now than it was in 1958 and ... this edition will continue to fill the need admirably ... it remains the best haematology reference for the general physician" British Medical JournalTable of ContentsPreface to Fifth Edition. Preface to First Edition. 1. Formation Blood Cells; Bone Marrow Biopsy. 2. The Red Cell; Basic Aspects of Anaemia. 3. Hypochromic Anaemia: Iron Deficiency and Siberoblastic Anaemia. 4. The Megaloblastic Anaemias. 5. Anaemia in Systemic Disorder; Diagnosis in Normochromic Normocytic Anaemia. 6. Pancytopenia; Aplastic Anaemias. 7. Disorders of Haemoglobin Structure and Synthesis. 8. The Haemolytic Anaemias. 9. White Cells: Neutrophilia and Eosinophilia; Neutropenia and Agranulocytosis; Infectious Monoucleosis. 10. The Leukaemias. 11. Tumours of Lymphiod Tissues; The Paraproteinaemias. 12. Polycythaemia; Myelofibrosis. 13. The Spleen: Hypersplenism and Splenomgaly. 14. The Haemorrhagic Disorder; Capillary and Platelet Defects. 15. Coagulation Disorder. 16. Thrombosis: Clinical Features and Management. 17. Blood Groups; Blood Transfusion; Acquired Immune Deficiency Syndrome. Index.

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Book SynopsisPowerfully involving narrative and incisive detail, clarity and inherent drama: Blood offers in abundance the qualities that define the best popular science writing. Here is the sweeping story of a substance that has been feared, revered, mythologized, and used in magic and medicine from earliest times--a substance that has become the center of a huge, secretive, and often dangerous worldwide commerce.Winner of the Los Angeles Times Book Prize, Blood was described by judges as a gripping page-turner, a significant contribution to the history of medicine and technology and a cautionary tale. Meticulously reported and exhaustively documented.

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Book SynopsisTrade Review"It remains the worldwide standard in laboratory haematology and no haematologist should be without it!" "This is an excellent book for new learners or for experienced practitioners wanting an update/refresher. If you want a basic book covering all aspects of laboratory and clinical hematology, this is the one for you. If you are a student, this is a must have." -Valerie L. Ng, PhD MD (Alameda County Medical Center/Highland Hospital) Doody's Score: 94 - 4 Stars!Table of Contents1 Collection and handling of blood 2 Reference ranges and normal values 3 Basic haematological techniques 4 Preparation and staining methods for blood and bone marrow films 5 Blood cell morphology in health and disease 6 Supplementary techniques including blood parasite diagnosis 7 Bone marrow biopsy 8 Molecular and cytogenetic analysis 9 Iron deficiency anaemia and iron overload 10 Investigation of megaloblastic anaemia: cobalamin, folate and metabolite status 11 Laboratory methods used in the investigation of the haemolytic anaemias 12 Investigation of the hereditary haemolytic anaemias: membrane and enzyme abnormalities 13 Acquired haemolytic anaemias 14 Investigation of variant haemoglobins and thalassaemias 15 Erythrocyte and leucocyte cytochemistry 16 Immunophenotyping by flow cytometry 17 Diagnostic radioisotopes in haematology 18 Investigation of haemostasis 19 Investigation of a thrombotic tendency 20 Laboratory control of anticoagulant, thrombolytic and antiplatelet therapy 21 Blood cell antigens and antibodies: erythrocytes, platelets and neutrophils 22 Laboratory aspects of blood transfusion 23 Approach to the diagnosis and classification of blood cell disorders 24 Laboratory organisation, management and safety 25 Quality assurance 26 Haematology in under-resourced laboratories

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Book SynopsisAccurate analysis of blood gases is vital to give information on a patient's respiratory and circulation state as well as the adequacy of resuscitation. This text guides the reader through the basic principles and a new system of interpretation.Table of ContentsHow to take an arterial blood gas sample; the survival guide to understanding acid-base balance; too much alkali; the survival guide to understanding oxygenation; too little oxygenation; complex situations; special situations; putting it all together; self assessments.

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Book SynopsisProceedings of the First International Symposium on Inhibitory Factors in the Regulation of Hematopoiesis, Paris (France), 26-28 April 1987.

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Book SynopsisThis [is a] concise, jargon-proofed, user-friendly volume."-Journal of the American Medical AssociationTrade ReviewA valuable resource for any cancer caregiver involved with home care... The mundane, the scary, and the technical are covered with practicality and aplomb. All chapters direct the acquisition of skills that lead to successful coping... This [is a] concise, jargon-proofed, user-friendly volume. Journal of the American Medical AssociationTable of ContentsChapter 1. Solving Problems Using the Home Care Guide for CancerChapter 2. Succeeding at CaregivingChapter 3. Fever and InfectionsChapter 4. Tiredness and FatigueChapter 5. Problems with AppetiteChapter 6. Problems with the MouthChapter 7. Nausea and VomitingChapter 8. DiarrheaChapter 9. ConstipationChapter 10. Cancer PainChapter 11. Problems with VeinsChapter 12. Problems with BleedingChapter 13. Skin Problems Chapter 14. Hair LossChapter 15. Sexual ProblemsChapter 16. Maintaining Positive ExperiencesChapter 17. Getting Companionship and Support from Family and FriendsChapter 18. Problems with Getting Information From Medical StaffChapter 19. Getting Help from Community Agencies and Volunteer GroupsChapter 20. Moving Around the House Chapter 21. Coordinating Care From One Treatment Setting to AnotherChapter 22. Coping With AnxietyChapter 23. Coping With DepressionIndex

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Book SynopsisWritten by global experts, this indispensable guide includes over 200 illustrations and essential information in clear tabular formatting, giving hematopathologists rapid access to diagnostic criteria at the microscope. General principles of bone marrow biopsy and aspirate processing are covered, together with the normal and reactive bone marrow, infective, infiltrative and neoplastic diseases. Chapters also guide readers through the use of immunohistochemistry, flow cytometry and molecular diagnosis, whilst extensive referencing provides further reading in specialist and rare topics. Whether working as a generalist, specialist, trainee or resident, this in an essential bench guide for hematopathologists at all levels of experience. The print book comes with access to the text and expandable figures online at Cambridge Core, which can be accessed via the code printed on the inside of the cover.

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Book Synopsis* Integrated textbook combining three subjects, haematology, clinical biochemistry and immunology to provide a one-stop text on blood science, in line with the new IBMS and NHS training structure * Suitable for blood science courses opening in many universities at senior Undergraduate level (units) and Masters level.Table of ContentsPreface, xiii Acknowledgements, xv List of Abbreviations, xvii About the Companion Website, xxi 1 Introduction to Blood Science, 1 1.1 What is blood science?, 1 1.2 Biochemistry, 6 1.3 Blood transfusion, 8 1.4 Genetics, 10 1.5 Haematology, 14 1.6 Immunology, 17 1.7 The role of blood science in modern healthcare, 19 1.8 What this book will achieve, 22 Summary, 23 References, 23 Further reading, 23 Web sites, 23 2 Analytical Techniques in Blood Science, 25 2.1 Venepuncture, 25 2.2 Anticoagulants, 26 2.3 Sample identification and tracking, 27 2.4 Technical and analytical confidence, 27 2.5 Major techniques, 32 2.6 Molecular genetics, 43 2.7 Point of care testing, 47 2.8 Health and safety in the laboratory, 48 Summary, 49 Further reading, 50 Web sites, 50 3 The Physiology of the Red Blood Cell, 51 3.1 Introduction, 51 3.2 The development of blood cells, 52 3.3 Erythropoiesis, 56 3.4 The red cell membrane, 58 3.5 The cytoplasm of the red cell, 60 3.6 Oxygen transport, 66 3.7 Recycling the red cell, 68 3.8 Red cell indices in the full blood count, 69 3.9 Morphology of the red cell, 72 Summary, 74 Further reading, 74 4 The Pathology of the Red Blood Cell, 75 4.1 Introduction: diseases of red cells, 75 4.2 Anaemia resulting from attack on, or stress to, the bone marrow, 78 4.3 Anaemia due to deficiency, 80 4.4 Intrinsic defects in the red cell, 85 4.5 External factors acting on healthy cells, 100 4.6 Erythrocytosis and polycythaemia, 103 4.7 Molecular genetics and red cell disease, 105 4.8 Inclusion bodies, 105 4.9 Case studies, 105 Summary, 107 References, 107 Further reading, 107 5 White Blood Cells in Health and Disease, 109 5.1 Introduction, 109 5.2 Leukopoiesis, 111 5.3 Neutrophils, 115 5.4 Lymphocytes, 116 5.5 Monocytes, 117 5.6 Eosinophils, 118 5.7 Basophils, 119 5.8 Leukocytes in action, 120 5.9 White cells in clinical medicine, 127 5.10 Case studies, 132 Summary, 132 Further reading, 133 6 White Blood Cell Malignancy 135 6.1 The genetic basis of leukocyte malignancy, 135 6.2 Tissue techniques in haemato-oncology, 139 6.3 Leukaemia, 141 6.4 Lymphoma, 149 6.5 Myeloma and related conditions, 152 6.6 Myelofibrosis and myelodysplasia, 157 6.7 Case studies, 157 Summary, 158 Further reading, 159 Guidelines, 159 7 The Physiology and Pathology of Haemostasis, 161 7.1 The blood vessel wall, 162 7.2 Platelets, 163 7.3 The coagulation pathway, 165 7.4 Haemostasis as the balance between thrombus formation and removal, 168 7.5 The haemostasis laboratory, 171 7.6 The pathology of thrombosis, 173 Summary, 175 Further reading, 175 8 The Diagnosis and Management of Disorders of Haemostasis, 177 8.1 Thrombosis 1: overactive platelets and thrombocytosis, 177 8.2 Thrombosis 2: overactive coagulation, 181 8.3 Haemorrhage 1: platelet underactivity and thrombocytopenia, 193 8.4 Haemorrhage 2: coagulation underactivity, 199 8.5 Disseminated intravascular coagulation, 203 8.6 Molecular genetics in haemostasis, 204 8.7 Case studies, 205 Summary, 206 References, 206 Further reading, 207 Guidelines, 207 Web sites, 207 9 Immunopathology, 209 9.1 Introduction, 209 9.2 Basics of the immune system, 210 9.3 Humoral immunity, 212 9.4 Immunopathology 1: immunodeficiency, 215 9.5 Immunopathology 2: hypersensitivity, 221 9.6 Immunopathology 3: autoimmune disease, 226 9.7 Immunotherapy, 232 9.8 The immunology laboratory, 234 9.9 Case studies, 238 Summary, 239 References, 240 Further reading, 240 Guidelines, 240 Web sites, 240 10 Immunogenetics and Histocompatibility, 241 10.1 The genetics of antigen recognition, 241 10.2 Human leukocyte antigens, 245 10.3 Transplantation, 251 10.4 Autoimmunity and human leukocyte antigens, 257 Summary, 260 Further reading, 260 Guidelines, 260 Web sites, 260 11 Blood Transfusion, 261 11.1 Blood collection and processing, 262 11.2 Blood groups, 265 11.3 Laboratory practice of blood transfusion, 273 11.4 Clinical practice of blood transfusion, 279 11.5 Hazards of blood transfusion, 281 Summary, 284 References, 284 Further reading, 284 Guidelines, 284 Web sites, 285 12 Waste Products, Electrolytes and Renal Disease, 287 12.1 Renal anatomy and physiology, 287 12.2 Homeostasis, 288 12.3 Excretion, 295 12.4 Renal endocrinology, 297 12.5 Renal disease, 298 12.6 Case studies, 301 Summary, 303 Further reading, 303 Guidelines, 303 Web sites, 303 13 Hydrogen Ions, pH, and Acid–Base Disorders, 305 13.1 Ions and molecules, 305 13.2 Blood gases, 308 13.3 Acidosis (pH <7.3), 312 13.4 Alkalosis (pH >7.5), 313 13.5 Mixed acid–base conditions, 314 13.6 Clinical interpretation, 314 13.7 Case studies, 315 Summary, 316 Further reading, 317 Web site, 317 14 Glucose, Lipids and Atherosclerosis, 319 14.1 Glucose, 319 14.2 Dyslipidaemia, 333 14.3 Atherosclerosis, 343 14.4 Case studies, 347 Summary, 348 Further reading, 348 Guidelines, 349 Web sites, 349 15 Calcium, Phosphate, Magnesium and Bone Disease, 351 15.1 Calcium, 352 15.2 Phosphates, 355 15.3 Magnesium, 355 15.4 The laboratory, 355 15.5 Disorders of calcium homeostasis, 357 15.6 Disorders of phosphate homeostasis, 360 15.7 Disorders of magnesium homeostasis, 362 15.8 Bone physiology, 363 15.9 Bone disease, 364 15.10 Case studies, 368 Summary, 369 Further reading, 370 Guidelines, 370 Web sites, 370 16 Nutrients and Gastrointestinal Disorders, 371 16.1 Nutrients, 371 16.2 The intestines, 375 16.3 Case studies, 381 Summary, 382 Further reading, 382 Guidelines, 382 17 Liver Function Tests and Plasma Proteins, 383 17.1 Anatomy and physiology of the liver, 384 17.2 Liver function tests, 389 17.3 Diseases of the liver, 390 17.4 Plasma proteins, 396 17.5 Case studies, 405 Summary, 406 Further reading, 406 Web sites, 406 18 Hormones and Endocrine Disorders, 407 18.1 Endocrine physiology, 407 18.2 The pathology of the endocrine system, 417 18.3 Case studies, 434 Summary, 435 Further reading, 435 Web sites, 436 19 Cancer and Tumour Markers, 437 19.1 General concepts in cancer biology, 437 19.2 Blood science and cancer, 440 19.3 Molecular genetics, 444 19.4 Case studies, 445 Summary, 446 Further reading, 446 Guidelines, 447 Web sites, 447 20 Inherited Metabolic Disorders, 449 20.1 The genetics of inheritance, 449 20.2 Molecular inherited metabolic disorders, 451 20.3 Organelle inherited metabolic disorders, 455 20.4 Antenatal diagnosis and neonatal screening, 455 20.5 Case studies, 456 Summary, 457 Further reading, 457 21 Drugs and Poisons, 459 21.1 Toxicology, 459 21.2 Toxicology of specific compounds, 461 21.3 Therapeutic drug monitoring, 465 21.4 Case studies, 468 Summary, 469 References, 469 Further reading, 469 22 Case Reports in Blood Science, 471 Abbreviations, 471 Case report 1, 472 Anaemia, hypercalcaemia, proteinuria, myeloma Case report 2, 473 Diabetes, glycated haemoglobin, chronic renal failure Case report 3, 474 Acute kidney injury, leucocytosis, neutrophilia, viruses Case report 4, 475 Part 1: Obesity, colorectal cancer, CEA, hypothyroidism. Part 2: Alcoholism, raised GGT and triacylglycerols Case report 5, 477 Part 1: No abnormalities. Part 2: Asthma, raised IgE. Part 3: Falling haemoglobin, rising ESR, lung cancer Case report 6, 479 Hypothyroidism, marginally reduced haemoglobin Case report 7, 480 Raised CRP, ESR, rheumatoid factor and anti-nuclear antibodies; borderline anti-dsDNA antibodies, low C3, low eGFR and so mild renal failure, systemic lupus erythematosus Case report 8, 481 Normal blood results in renal transplantation Case report 9, 482 Falling albumin, eGFR, haemoglobin, red cell count and platelets, rising ESR, white cell count and neutrophila, CRP, urea and creatinine, septicaemia Case report 10, 484 Microcytic anaemia, thrombocytopenia, lymphocytosis, abnormal LFTs, falling albumin, raised CRP, myositis with raised CK, viruses Case report 11, 486 Acidosis, hyperglycaemia, diabetic ketoacidosis, acute renal injury, raised urea and creatinine Case report 12, 487 Low haemoglobin, thrombocytopenia, raised CRP and d-dimers, abnormal LFTs, malaria, pregnancy Case report 13, 488 Raised aldosterone, hypernatraemia, hypokalaemia, Conn’s syndrome Case report 14, 489 Paediatric diabetic ketoacidosis, hyperglycaemia, low bicarbonate, raised phosphates, ALP and proteins References, 490 Appendix: Reference Ranges, 491 Further Reading, 493 Glossary, 495 Index, 519

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Book Synopsis* Integrated textbook combining three subjects, haematology, clinical biochemistry and immunology to provide a one-stop text on blood science, in line with the new IBMS and NHS training structure * Suitable for blood science courses opening in many universities at senior Undergraduate level (units) and Masters level.Table of ContentsPreface, xiii Acknowledgements, xv List of Abbreviations, xvii About the Companion Website, xxi 1 Introduction to Blood Science, 1 1.1 What is blood science?, 1 1.2 Biochemistry, 6 1.3 Blood transfusion, 8 1.4 Genetics, 10 1.5 Haematology, 14 1.6 Immunology, 17 1.7 The role of blood science in modern healthcare, 19 1.8 What this book will achieve, 22 Summary, 23 References, 23 Further reading, 23 Web sites, 23 2 Analytical Techniques in Blood Science, 25 2.1 Venepuncture, 25 2.2 Anticoagulants, 26 2.3 Sample identification and tracking, 27 2.4 Technical and analytical confidence, 27 2.5 Major techniques, 32 2.6 Molecular genetics, 43 2.7 Point of care testing, 47 2.8 Health and safety in the laboratory, 48 Summary, 49 Further reading, 50 Web sites, 50 3 The Physiology of the Red Blood Cell, 51 3.1 Introduction, 51 3.2 The development of blood cells, 52 3.3 Erythropoiesis, 56 3.4 The red cell membrane, 58 3.5 The cytoplasm of the red cell, 60 3.6 Oxygen transport, 66 3.7 Recycling the red cell, 68 3.8 Red cell indices in the full blood count, 69 3.9 Morphology of the red cell, 72 Summary, 74 Further reading, 74 4 The Pathology of the Red Blood Cell, 75 4.1 Introduction: diseases of red cells, 75 4.2 Anaemia resulting from attack on, or stress to, the bone marrow, 78 4.3 Anaemia due to deficiency, 80 4.4 Intrinsic defects in the red cell, 85 4.5 External factors acting on healthy cells, 100 4.6 Erythrocytosis and polycythaemia, 103 4.7 Molecular genetics and red cell disease, 105 4.8 Inclusion bodies, 105 4.9 Case studies, 105 Summary, 107 References, 107 Further reading, 107 5 White Blood Cells in Health and Disease, 109 5.1 Introduction, 109 5.2 Leukopoiesis, 111 5.3 Neutrophils, 115 5.4 Lymphocytes, 116 5.5 Monocytes, 117 5.6 Eosinophils, 118 5.7 Basophils, 119 5.8 Leukocytes in action, 120 5.9 White cells in clinical medicine, 127 5.10 Case studies, 132 Summary, 132 Further reading, 133 6 White Blood Cell Malignancy 135 6.1 The genetic basis of leukocyte malignancy, 135 6.2 Tissue techniques in haemato-oncology, 139 6.3 Leukaemia, 141 6.4 Lymphoma, 149 6.5 Myeloma and related conditions, 152 6.6 Myelofibrosis and myelodysplasia, 157 6.7 Case studies, 157 Summary, 158 Further reading, 159 Guidelines, 159 7 The Physiology and Pathology of Haemostasis, 161 7.1 The blood vessel wall, 162 7.2 Platelets, 163 7.3 The coagulation pathway, 165 7.4 Haemostasis as the balance between thrombus formation and removal, 168 7.5 The haemostasis laboratory, 171 7.6 The pathology of thrombosis, 173 Summary, 175 Further reading, 175 8 The Diagnosis and Management of Disorders of Haemostasis, 177 8.1 Thrombosis 1: overactive platelets and thrombocytosis, 177 8.2 Thrombosis 2: overactive coagulation, 181 8.3 Haemorrhage 1: platelet underactivity and thrombocytopenia, 193 8.4 Haemorrhage 2: coagulation underactivity, 199 8.5 Disseminated intravascular coagulation, 203 8.6 Molecular genetics in haemostasis, 204 8.7 Case studies, 205 Summary, 206 References, 206 Further reading, 207 Guidelines, 207 Web sites, 207 9 Immunopathology, 209 9.1 Introduction, 209 9.2 Basics of the immune system, 210 9.3 Humoral immunity, 212 9.4 Immunopathology 1: immunodeficiency, 215 9.5 Immunopathology 2: hypersensitivity, 221 9.6 Immunopathology 3: autoimmune disease, 226 9.7 Immunotherapy, 232 9.8 The immunology laboratory, 234 9.9 Case studies, 238 Summary, 239 References, 240 Further reading, 240 Guidelines, 240 Web sites, 240 10 Immunogenetics and Histocompatibility, 241 10.1 The genetics of antigen recognition, 241 10.2 Human leukocyte antigens, 245 10.3 Transplantation, 251 10.4 Autoimmunity and human leukocyte antigens, 257 Summary, 260 Further reading, 260 Guidelines, 260 Web sites, 260 11 Blood Transfusion, 261 11.1 Blood collection and processing, 262 11.2 Blood groups, 265 11.3 Laboratory practice of blood transfusion, 273 11.4 Clinical practice of blood transfusion, 279 11.5 Hazards of blood transfusion, 281 Summary, 284 References, 284 Further reading, 284 Guidelines, 284 Web sites, 285 12 Waste Products, Electrolytes and Renal Disease, 287 12.1 Renal anatomy and physiology, 287 12.2 Homeostasis, 288 12.3 Excretion, 295 12.4 Renal endocrinology, 297 12.5 Renal disease, 298 12.6 Case studies, 301 Summary, 303 Further reading, 303 Guidelines, 303 Web sites, 303 13 Hydrogen Ions, pH, and Acid–Base Disorders, 305 13.1 Ions and molecules, 305 13.2 Blood gases, 308 13.3 Acidosis (pH <7.3), 312 13.4 Alkalosis (pH >7.5), 313 13.5 Mixed acid–base conditions, 314 13.6 Clinical interpretation, 314 13.7 Case studies, 315 Summary, 316 Further reading, 317 Web site, 317 14 Glucose, Lipids and Atherosclerosis, 319 14.1 Glucose, 319 14.2 Dyslipidaemia, 333 14.3 Atherosclerosis, 343 14.4 Case studies, 347 Summary, 348 Further reading, 348 Guidelines, 349 Web sites, 349 15 Calcium, Phosphate, Magnesium and Bone Disease, 351 15.1 Calcium, 352 15.2 Phosphates, 355 15.3 Magnesium, 355 15.4 The laboratory, 355 15.5 Disorders of calcium homeostasis, 357 15.6 Disorders of phosphate homeostasis, 360 15.7 Disorders of magnesium homeostasis, 362 15.8 Bone physiology, 363 15.9 Bone disease, 364 15.10 Case studies, 368 Summary, 369 Further reading, 370 Guidelines, 370 Web sites, 370 16 Nutrients and Gastrointestinal Disorders, 371 16.1 Nutrients, 371 16.2 The intestines, 375 16.3 Case studies, 381 Summary, 382 Further reading, 382 Guidelines, 382 17 Liver Function Tests and Plasma Proteins, 383 17.1 Anatomy and physiology of the liver, 384 17.2 Liver function tests, 389 17.3 Diseases of the liver, 390 17.4 Plasma proteins, 396 17.5 Case studies, 405 Summary, 406 Further reading, 406 Web sites, 406 18 Hormones and Endocrine Disorders, 407 18.1 Endocrine physiology, 407 18.2 The pathology of the endocrine system, 417 18.3 Case studies, 434 Summary, 435 Further reading, 435 Web sites, 436 19 Cancer and Tumour Markers, 437 19.1 General concepts in cancer biology, 437 19.2 Blood science and cancer, 440 19.3 Molecular genetics, 444 19.4 Case studies, 445 Summary, 446 Further reading, 446 Guidelines, 447 Web sites, 447 20 Inherited Metabolic Disorders, 449 20.1 The genetics of inheritance, 449 20.2 Molecular inherited metabolic disorders, 451 20.3 Organelle inherited metabolic disorders, 455 20.4 Antenatal diagnosis and neonatal screening, 455 20.5 Case studies, 456 Summary, 457 Further reading, 457 21 Drugs and Poisons, 459 21.1 Toxicology, 459 21.2 Toxicology of specific compounds, 461 21.3 Therapeutic drug monitoring, 465 21.4 Case studies, 468 Summary, 469 References, 469 Further reading, 469 22 Case Reports in Blood Science, 471 Abbreviations, 471 Case report 1, 472 Anaemia, hypercalcaemia, proteinuria, myeloma Case report 2, 473 Diabetes, glycated haemoglobin, chronic renal failure Case report 3, 474 Acute kidney injury, leucocytosis, neutrophilia, viruses Case report 4, 475 Part 1: Obesity, colorectal cancer, CEA, hypothyroidism. Part 2: Alcoholism, raised GGT and triacylglycerols Case report 5, 477 Part 1: No abnormalities. Part 2: Asthma, raised IgE. Part 3: Falling haemoglobin, rising ESR, lung cancer Case report 6, 479 Hypothyroidism, marginally reduced haemoglobin Case report 7, 480 Raised CRP, ESR, rheumatoid factor and anti-nuclear antibodies; borderline anti-dsDNA antibodies, low C3, low eGFR and so mild renal failure, systemic lupus erythematosus Case report 8, 481 Normal blood results in renal transplantation Case report 9, 482 Falling albumin, eGFR, haemoglobin, red cell count and platelets, rising ESR, white cell count and neutrophila, CRP, urea and creatinine, septicaemia Case report 10, 484 Microcytic anaemia, thrombocytopenia, lymphocytosis, abnormal LFTs, falling albumin, raised CRP, myositis with raised CK, viruses Case report 11, 486 Acidosis, hyperglycaemia, diabetic ketoacidosis, acute renal injury, raised urea and creatinine Case report 12, 487 Low haemoglobin, thrombocytopenia, raised CRP and d-dimers, abnormal LFTs, malaria, pregnancy Case report 13, 488 Raised aldosterone, hypernatraemia, hypokalaemia, Conn’s syndrome Case report 14, 489 Paediatric diabetic ketoacidosis, hyperglycaemia, low bicarbonate, raised phosphates, ALP and proteins References, 490 Appendix: Reference Ranges, 491 Further Reading, 493 Glossary, 495 Index, 519

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Book SynopsisTextbook of Hemophilia, 3rd edition Edited by Christine A. Lee, MA, MD, DSc, FRCP, FRCPath, FRCOG Emeritus Professor of Haemophilia, University of London, London, UK Erik E. Berntorp, MD, PhD Professor of Coagulation Medicine, Lund University Malmö Centre for Thrombosis and Haemostasis, Skåne University Hospital, Malmö, Sweden W. Keith Hoots, MD Director, Division of Blood Diseases and Resources, National Heart, Lung and Blood Institute National Institutes of Health, Bethesda, MD; Professor of Pediatrics and Internal Medicine, University of Texas Medical School at Houston, Houston, TX, USA Without doubt, Textbook of Hemophilia, 3rd edition is the definitive reference source on all aspects of haemophilia including diagnosis, management and treatment. Edited by three, world-renowned experts on haemophilia, this completely revised resource features chapters wriTable of ContentsContributors ix Historical introduction xv Christine A. Lee Part I: Introduction 1 Overview of hemostasis 3 Kathleen Brummel Ziedins and Kenneth G. Mann 2 Cellular processing of factor VIII and factor IX 9 Michael U. Callaghan and Randal J. Kaufman Part II: Hemophilia A 3 Molecular basis of hemophilia A 23 Geoffrey Kemball-Cook and Keith Gomez 4 Prophylaxis 33 Kathelijn Fischer and H. Marijke van den Berg Part III: Inhibitors to Factor VIII 5 Inhibitors to factor VIII: immunology 43 Jean-Marie R. Saint-Remy and Marc G. Jacquemin 6 Genetic and Environmental Risk Factors for Factor VIII inhibitor development 48 Jan Astermark 7 Epidemiology of inhibitors in hemophilia 53 Alfonso Iorio 8 Inhibitors to factor VIII: mild and moderate hemophilia 59 Kathelijne Peerlinck and Marc Jacquemin 9 Inhibitors to factor VIII/IX: immune tolerance 64 Donna M. DiMichele 10 Prophylaxis in inhibitor patients 72 Alessandro Gringeri 11 Inhibitors to factor VIII: treatment of acute bleeds 78 Claude Negrier Part IV: Acquired Hemophilia 12 Acquired inhibitors to factor VIII 87 Craig M. Kessler Part V: Hemophilia B 13 Hemophilia B: molecular basis 97 Keith Gomez and Pratima Chowdary 14 Factor IX inhibitors in hemophilia B 103 Meera B. Chitlur and Jeanne M. Lusher 15 Treatment of inhibitors in hemophilia B 107 Anand Tandra and Amy D. Shapiro Part VI: Pharmacokinetics of Factors VIII and IX 16 Pharmacokinetics 117 Sven Björkman 17 Individualized dosing 123 Peter W. Collins Part VII: Hemophilia: Birth to Old Age 18 Neonate with hemophilia 131 Angela E. Thomas and Elizabeth A. Chalmers 19 Work-up of a bleeding child 138 Manuel D. Carcao and Victor S. Blanchette 20 Care of the child with hemophilia 145 Rolf C.R. Ljung 21 Hemophilia in adolescence 150 Pia Petrini 22 Old age medicine and hemophilia 154 Evelien P. Mauser-Bunschoten and Roger E.G. Schutgens Part VIII: Products Used to Treat Hemophilia 23 Products used to treat hemophilia: recombinant products 165 Midori Shima and Akira Yoshioka 24 Products used to treat hemophilia: plasma-derived coagulation factor concentrates 174 Paul L.F. Giangrande 25 Products used to treat hemophilia: dosing 180 Miguel A. Escobar 26 Products used to treat hemophilia: regulation 185 Albert Farrugia 27 New drugs in the pipeline: from concept to clinic 192 Leonard A. Valentino Part IX: Surgical management 28 General surgical management of patients with hemophilia 199 Cindy Leissinger and Rebecca Kruse-Jarres 29 Continuous infusion of coagulation products in hemophilia 204 Angelika Batorova and Uri Martinowitz 30 Surgery in inhibitor patients 213 Pål Andrè Holme Part X: Musculoskeletal 31 Joint replacement in patients with hemophilia 221 Nicholas Goddard 32 Medical synovectomy (synoviorthesis) in hemophilia: radiosynovectomy and chemical synovectomy 228 E. Carlos Rodriguez-Merchan 33 Pseudotumors in patients with hemophilia 233 Michael Heim and Uri Martinowitz 34 Imaging modalities for assessment of hemophilic arthropathy 237 Andrea S. Doria and Björn Lundin 35 Physiotherapy in the management of hemophilia 247 Sébastien Lobet and David Stephensen 36 Outcome assessment in hemophilia 253 Pradeep M. Poonnoose and Alok Srivastava Part XI: Transfusion-transmitted Disease 37 Viral hepatitis and hemophilia 265 Michael Makris and Geoffrey Dusheiko 38 Transfusion-transmitted disease: emerging infections 272 Thomas R. Kreil 39 vCJD and hemophilia 277 Carolyn M. Millar Part XII: Gene Therapy 40 Hemophilia gene therapy: an overview 285 David Lillicrap 41 Gene therapy trials in hemophilia A and B 291 Katherine A. High 42 Gene therapy: molecular engineering of factor VIII and factor IX 298 Sundar R. Selvaraj and Steven W. Pipe Part XIII: Laboratory 43 Laboratory and quality control of assays 311 Steve Kitchen 44 Standardization of assays in hemophilia 318 Sanj Raut and Trevor W. Barrowcliffe 45 Global laboratory assays in hemophilia 328 Benny Sørensen and Guy Young Part XIV: Women and Bleeding Disorders 46 Obstetrics and gynecology: hemophilia 337 Rezan A. Kadir and Christine A. Lee 47 Women and von Willebrand disease 345 Peter A. Kouides Part XV: von Willebrand Disease 48 von Willebrand disease: molecular aspects 355 Daniel Hampshire and Anne Goodeve 49 von Willebrand disease: epidemiology 362 Francesco Rodeghiero and Giancarlo Castaman 50 von Willebrand disease: biological diagnosis 370 Veronica H. Flood and Robert R. Montgomery 51 Classification and clinical aspects of von Willebrand disease 377 Augusto B. Federici 52 Treatment of von Willebrand disease: desmopressin 386 Pier M. Mannucci 53 Treatment of von Willebrand disease: therapeutic concentrates 390 Erik E. Berntorp Part XVI: Rare Bleeding Disorders 54 Factor II 399 Jan Astermark 55 Factor V and combined factor V and VIII deficiencies 403 Flora Peyvandi and Marzia Menegatti 56 Congenital factor VII deficiency 413 Angelika Batorova 57 Factor X and factor X deficiency 421 David J. Perry 58 Factor XI deficiency 428 Paula H.B. Bolton-Maggs and Uri Seligsohn 59 Factor XIII deficiency 436 Diane Nugent and Loan Hsieh 60 Fibrinogen deficiency 445 Michael Laffan 61 Miscellaneous rare bleeding disorders 452 Frederico Xavier and Amy D. Shapiro Part XVII: Emergency Medicine 62 Emergency management of hemophilia 463 W. Keith Hoots Part XVIII: Evaluation of Hemophilia 63 Clinical trials and other methodologies 473 Sharyne M. Donfield and Alice E. Lail 64 Quality of life in hemophilia 478 Sylvia von Mackensen and Alessandro Gringeri 65 The economics of hemophilia treatment 489 Katarina Steen Carlsson and Erik E. Berntorp Part XIX: Comprehensive Care and Delivery of Care 66 Hemophilia databases 497 Charles R.M. Hay 67 Comprehensive care and delivery of care: the developed world 502 Christopher A. Ludlam and Cedric R.J.R. Hermans 68 Comprehensive care and delivery of care in hemophilia: the developing world 508 Alok Srivastava and Auro Viswabandya 69 Comprehensive care and delivery of care: the global perspective 515 Mark W. Skinner and Alison M. Street Index 523 Color plate section can be found facing page 202

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Book SynopsisA clinical guide to transplantation in lymphoma to present advanced knowledge on how to integrate, transplantat and other novel therapies in patients with lymphoid malignancies. It provides practical management guidance on how to integrate, transplant and other novel therapies in patients with lymphoid malignancies.Trade ReviewSir William Osler is reputed to have said, “Listen to the patient and he will give you the answer.” Had he been alive now and practicing transplantation for lymphoma, he could have well said “Read the Clinical Guide to Transplantation in Lymphoma and it will give you the answer.” These reviewers are very impressed by the breadth and scope of this book edited by Drs. Bipin Savani and Mohamed Mohty, ably aided by an array of expert contributors from all over the world.Clinical Guide to Transplantation in Lymphoma is extremely easy to read and very well written. In this era ofexponential information growth this book is surprisingly current, with the latest references. It has an ambitious scope, setting out to cover all aspects of transplantation in lymphoma and managing to meet that expectation.Chapters are laid out in logical sequence divided into 2 sections. Section 1 is particularly interesting and haschapters on the historical perspective of transplantation for lymphoma, transplant data collection and reporting, and analytical methods. The remainder of section 1 describes the general principles of transplantation in lymphomas, addressing issues such as mobilization, preparative regimens, and management of the early, late, and long-term issues arising after transplantation. Some chapters include transplantation for lymphoma in children, adults, and young adolescents; pretransplant evaluation; preparative regimens for autologous and allogeneic transplants; stem cell mobilization and stem cell source; post-transplant follow-up for autologousand allogeneic transplant, and a novel chapter, “First 100 Days of the Autologous Hematopoietic Stem Cell Transplantation Process in Lymphoma.” The chapters in section 1 are broadly applicable and would prove invaluable to trainees pursuing fellowships in hematopoietic cell transplantation.Section 2 is laid out as a chapter by chapter discussion of various lymphoma histologies and the applicability of hematopoietic cell transplantation in each. One can return to some of these chapters again and again because all common and most rare lymphoma subtypes (including HIV-associated lymphoma) are discussed in excellent detail. We found each one of these chapters to be remarkably up to date. In a field such ashematopoietic cell transplantation,where there is considerable ambiguity and few randomized studies, the authors and editors have maintained a neutral and unbiased tone,discussing the available data andguidelines exhaustively.Very few similar textbooks focus on transplantation in a disease group. Clinical Guide to Transplantation in Lymphoma is concise enough, practical, and clinically oriented to be considered a practical manual but at the same time manages to be comprehensive. Some unique features in this book are the numerous excellent graphs and tables and the discussion of case studies and clinical guidelines (United States and European) wherever applicable. We found very few typographic errors. For future editions we recommend at least 1 chapter devoted to the emerging field of cellular immunotherapy.The editors and the contributors need to be congratulated for an encyclopedic work that still manages to be a ready reference guide. This book will be used extensively and should be in the library of every transplanter.We hope it runs into many future editions and becomes the authoritative textbook for transplantation in lymphoma. (Yogesh Jethava, Parameswaran Hari, University of Arkansas for Medical Science, Biology of Blood and Marrow Transplantation, Nov 2015)Table of ContentsList of contributors vii Foreword xi Introduction 1 Section 1: Transplantation in lymphomas 1 Lymphoma and transplantation: historical perspective 5Andrew R. Rezvani 2 Lymphoma: working committee and data reporting after transplantation in lymphoma 13Wael Saber, Mehdi Hamadani, Shahrukh Hashmi and Parameswaran Hari 3 Use of transplantation in lymphoma: adults 23Parastoo Bahrami Dahi, Gabriela Soriano Hobbs and Miguel]Angel Perales 4 Hematopoietic stem cell transplantation for lymphoma in children, adolescents, and young adults 31Nader Kim El]Mallawany and Mitchell S. Cairo 5 Preparative regimens for lymphoma: autologous hematopoietic stem cell transplantation 45Taiga Nishihori, Karma Z. Salem, Ernesto Ayala and Mohamed A. Kharfan]Dabaja 6 Preparative regimens for lymphoma: allogeneic hematopoietic stem cell transplantation 57Mohamed A. Kharfan]Dabaja, Najla El]Jurdi, Mehdi Hamadani and Ernesto Ayala 7 Pretransplantation evaluation, comorbidities, and nondisease]related eligibility criteria for transplantation in lymphoma, 69Melissa Logue 8 Stem cell mobilization in lymphoma patients 75Tarah Ballinger, Bipin N. Savani and Mohamad Mohty 9 Allogeneic hematopoietic stem cell transplantation for lymphoma: stem cell source, donor, and HLA matching 85Michael Green and Mitchell Horwitz 10 Management of early and late toxicities of autologous hematopoietic stem cell transplantation 93Sai Ravi Pingali and Yago Nieto 11 Long]term follow]up of lymphoma patients after allogeneic hematopoietic cell transplantation 103Shylaja Mani and Navneet S. Majhail 12 First 100 days of the autologous hematopoietic stem cell transplantation process in lymphoma 109Angela Moreschi Woods 13 First 100 days of the allogeneic hematopoietic stem cell transplantation process in lymphoma 113Angela Moreschi Woods Section 2: Management 14 Stem cell transplantation in follicular lymphoma,119Satyajit Kosuri and Koen Van Besien 15 Chronic lymphocytic leukemia/small lymphocytic lymphoma 133Salyka Sengsayadeth and Wichai Chinratanalab 16 Diffuse large B]cell lymphoma 145Lauren Veltri, Bipin N. Savani, Mohamed A. Kharfan]Dabaja, Mehdi Hamadani and Abraham S. Kanate 17 Mantle cell lymphoma 161Sascha Dietrich and Peter Dreger 18 Hodgkin lymphoma 173Eva Domingo]Domenech and Anna Sureda 19 Peripheral T]cell lymphomas 187Giulia Perrone, Chiara De Philippis, Lucia Farina and Paolo Corradini 20 Transplantation in Burkitt and lymphoblastic lymphoma 201Gregory A. Hale 21 Transplantation in adult T]cell leukemia/lymphoma 209Ali Bazarbachi and Olivier Hermine 22 Hematopoietic cell transplantation for HIV]related lymphomas 217Joseph C. Alvarnas 23 Stem cell transplantation for mycosis fungoides/Sézary syndrome 233Eric D. Jacobsen 24 Role of transplantation in lymphoplasmacytic lymphoma 241Silvia Montoto and Charalampia Kyriakou 25 Transplantation outcome in primary mediastinal large B]cell lymphoma 247Amanda F. Cashen 26 Management of post]transplant lymphoproliferative disorders 253Jan Styczynski and Per Ljungman Appendix I Follow]up calendar after autologous stem cell transplantation in lymphoma 261Angela Moreschi Woods Appendix II Follow]up calendar after allogeneic stem cell transplantation in lymphoma 263Angela Moreschi Woods Index 265

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Book SynopsisProviding the practicing and trainee hematologist with a practical and immediately applicable compendium of answers the Clinical Manual of Blood and Bone Marrow Transplantation covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program. Supplies the practicing and trainee hematologist with a practical and immediately applicable compendium of answers to clinical questionsCovers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant programContains concise chapters written with a focus on tables, algorithms and figures to aid rapid referralBenefits from expert contributions from an international authorshipTrade Review"... the book provides a concise practical expert review in a well-organized format of 42 chapters, each annotated with numerous practical headings to enhance focused learning. The expert authors of each chapter in the Clinical Manual of Blood and Bone Marrow Transplantation are part of that success story, and their up-to-date contributions to the field are elucidated in the clearest of terms in this worthy addition to the literature. This book is recommended for The ASCO Post readers, especially residents and fellows who are interested in pursuing a career in blood cancers" (The ASCO Post, September 2017)Table of ContentsContributors, ix Preface, xiv 1 Donor and graft selection strategy, 1Ayman Saad, Marisa B. Marques, and Shin Mineishi 2 HLA typing and implications, 9Bronwen E. Shaw and Stephen R. Spellman 3 Risk]benefit assessment in allogeneic hematopoietic transplant: Factors, scores, and models, 19Mahmoud Elsawy and Mohamed L. Sorror 4 Donor and recipient pre]transplant evaluation, 36Shuang Fu and Navneet S. Majhail 5 Autologous and allogeneic progenitor cell mobilization, 45Racquel D. Innis]Shelton and Luciano J. Costa 6 Hematopoietic stem and progenitor cell collection by apheresis: Techniques and tricks, 53Anand Padmanabhan 7 Hematopoietic cell processing: From procurement to infusion, 59Jay S. Raval, Kathryn McKay, and Yara A. Park 8 Graft manipulation: T-cell depletion and beyond, 66Christina Cho and Miguel]Angel Perales 9 Graft]versus]host disease prophylaxis, 73Melhem Solh and Asad Bashey 10 Acute lymphoblastic leukemia, 80Ghada Zakout and Adele K. Fielding 11 Acute myeloid leukemia, 89Hillard M. Lazarus and Masumi Ueda 12 Myelodysplastic syndromes, 97Melinda Biernacki and H. Joachim Deeg 13 Chronic myelogenous leukemia, 108Daniel Egan and Jerald Radich 14 Philadelphia chromosome negative myeloproliferative neoplasms, 116Nicolaus Kröger 15 Chronic lymphocytic leukemia, 123Fabienne McClanahan Lucas and John Gribben 16 Hodgkin Lymphoma, 131Anna Sureda and Eva Domingo]Domenech 17 Indolent lymphomas, 140Narendranath Epperla, Hamza Hashmi, and Mehdi Hamadani 18 Diffuse large B-cell lymphoma, 151Syed Abbas Ali, Istvan Redei, and Syed A. Abutalib 19 Mantle cell lymphoma, 164Narendranath Epperla and Timothy S. Fenske 20 T-cell lymphoma, 179Adrienne A. Phillips and Koen van Besien 21 Primary CNS lymphoma, 188Henry C. Fung, Philip Pancari, and Patricia Kropf 22 Autologous hematopoietic transplant in multiple myeloma, 194Nisha S. Joseph, Ajay K. Nooka, and Sagar Lonial 23 Allogeneic hematopoietic transplant in multiple myeloma, 207Parameswaran Hari and Binod Dhakal 24 Light]chain amyloidosis, 214Amara S. Hussain and Anita D’Souza 25 Autoimmune disorders, 221Adam Bryant and Harold Atkins 26 Testicular cancer, 229Moshe C. Ornstein, Navneet S. Majhail, and Timothy Gilligan 27 Sickle cell disease, 236Sonali Chaudhury and Shalini Shenoy 28 Hematopoietic cell transplant in thalassemia, 246Emanuele Angelucci and Federica Pilo 29 Fanconi anemia, 255Flore Sicre de Fontbrune, Jean Soulier, and Regis Peffault de Latour 30 Immunodeficiency disorders, 264Jennifer A. Kanakry and Dennis D. Hickstein 31 Inherited metabolic disorders, 272Jaap Jan Boelens and Robert F. Wynn 32 Aplastic anemia and paroxysmal nocturnal hemoglobinuria, 281Andrew C. Dietz and Michael A. Pulsipher 33 HIV infection and transplantation, 290Nitya Nathwani, Stephen J. Forman, and Amrita Krishnan 34 Engraftment and graft failure: Assessment and practical considerations, 297Yogesh Jethava, Madan Jagasia, Mohamed Mohty, and Bipin N. Savani 35 Immune reconstitution and tolerance, 304udovic Belle and William R. Drobyski 36 Donor lymphocyte infusion, 315David C. Halverson and Daniel Fowler 37 Diagnosis and treatment of acute graft]versus]host disease, 324Natasha Kekre and Vincent T. Ho 38 Diagnosis and treatment of chronic graft]versus]host disease, 334Sabarinath Venniyil Radhakrishnan and Daniel R. Couriel 39 Prevention and treatment of infection, 348Corrado Girmenia, Gian Maria Rossolini, and Claudio Viscoli 40 Early non]infectious complications after hematopoietic cell transplantation, 359Piyanuch Kongtim and Stefan O. Ciurea 41 Post]transplant lymphoproliferative disorders, 369Michael D. Keller, Conrad R. Cruz, and Catherine M. Bollard 42 Survivorship issues after transplantation, 376Vanessa E. Kennedy, Madan Jagasia, and Bipin N. Savani Index, 384

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Book SynopsisTable of ContentsPreface vii Part 1 Introduction 1 1 Introduction to endocrinology 2 Part 2 Disorders of the hypothalamic–pituitary axis 5 2 The hypothalamic–pituitary axis and its assessment 6 3 Acromegaly 8 4 Cushing’s syndrome 10 5 Hypopituitarism and non-functioning pituitary adenomas 12 6 Prolactinoma and hyperprolactinaemia 14 Part 3 Disorders of thirst and fluid balance 17 7 Hypernatraemia and diabetes insipidus 18 8 Hyponatraemia and SIADH 20 Part 4 Thyroid disorders 23 9 Thyroid function 24 10 Hyperthyroidism: clinical presentation and investigation 26 11 Hyperthyroidism: management and ophthalmopathy 28 12 Hyperthyroidism: special circumstances 30 13 Hypothyroidism 32 14 Goitre, thyroid nodules and cancer 34 Part 5 Disorders of calcium homeostasis 37 15 Physiology of calcium, PTH and vitamin D metabolism 38 16 Hypercalcaemia 40 17 Hypocalcaemia 42 18 Osteoporosis 44 Part 6 Disorders of the adrenal gland 47 19 Steroid physiology and biochemical assessment 48 20 Adrenal insufficiency 50 21 Adrenocortical tumours 52 22 Disorders of the adrenal medulla 54 Part 7 Disorders of the reproductive system 57 23 Physiology of the reproductive system 58 24 Growth, puberty and sexual differentiation 60 25 Menstrual disturbance 62 26 Hyperandrogenism 64 27 Menopause and HRT 66 28 Male hypogonadism 68 29 Gynaecomastia 70 30 Infertility 72 Part 8 Neuroendocrine tumours 75 31 Neuroendocrine tumours 76 32 Neuroendocrine tumours: management 78 33 Inherited endocrine tumour syndromes 80 34 Spontaneous hypoglycaemia 82 Part 9 Endocrine emergencies 85 35 Adrenal crisis 86 36 Pituitary apoplexy 88 37 Myxoedema coma 90 38 Thyroid storm 92 39 Acute hyponatraemia 94 40 Severe hypercalcaemia 96 41 Acute hypocalcaemia 98 Part 10 Diabetes mellitus 101 42 Overview 102 43 Diagnosis and monitoring 104 44 Classification 106 45 Type 1 diabetes: aetiology and clinical presentation 108 46 Type 1 diabetes: insulin and other therapies 110 47 Type 2 diabetes: aetiology and clinical presentation 112 48 Type 2 diabetes: treatment 114 49 Macrovascular complications 116 50 Microvascular complications 118 51 Diabetic foot disease 120 52 Diabetic ketoacidosis 122 53 Hyperglycaemic hyperosmolar state 124 54 Hypoglycaemia 126 55 Peri-operative management 128 56 Management of acute illness 131 57 Insulin infusions 134 58 Pregnancy and diabetes 136 59 Genetics of diabetes 138 60 The multidisciplinary team 140 61 Lipid disorders 142 62 Appetite and weight 144 63 Obesity and anorexia 146 Index 148

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Book SynopsisThe third edition of this popular pocket book, A Beginner's Guide to Blood Cells written by Professor Barbara Bain, provides a concise introduction to normal and abnormal blood cells and blood counts for trainees in haematology. Includes a brand new chapter on emergency morphology, designed to make the clinical significance and urgency of certain laboratory findings clear for biomedical scientists and to assist trainee haematologists in the recognition of major clinically important abnormalities Contains exceptional full colour images throughout Introduces important basic concepts of hematology, setting haematological findings in a clinical context Provides a fully updated self-assessment section An essential resource for trainee haematologists, biomedical scientists, and biomedical science and medical students Table of ContentsPreface vii Abbreviations viii 1 The Blood Film and Count 1 Blood 1 The blood film 1 The blood count 17 Normal ranges 20 How to examine a blood film 22 2 Assessing Red Cells 29 Assessing red cell number and distribution (anaemia polycythaemia rouleaux formation red cell agglutination) 29 Assessing red cell size (microcytosis macrocytosis anisocytosis) 32 Assessing red cell shape (poikilocytosis) 32 Assessing red cell colour (hypochromia hyperchromia anisochromasia polychromasia) 32 Detecting red cell inclusions (Pappenheimer bodies basophilic stippling Howell–Jolly bodies) 41 The full blood count in red cell assessment 43 3 Assessing White Cells and Platelets 45 Assessing white cell and platelet numbers 45 Assessing neutrophil morphology 46 Assessing lymphocyte morphology 51 Assessing morphology of monocytes eosinophils and basophils 53 Assessing platelet morphology 53 4 Haematological Findings in Health and Disease 55 The blood film and count in healthy individuals 55 Abnormalities of red cells 56 Abnormalities of white cells 77 5 Emergency Morphology: The Relevance of the Full Blood Count and Blood Film in Acute Illness 97 Thrombocytopenia 97 Thrombotic microangiopathy and microangiopathic haemolytic anaemia 98 Other acute anaemia 100 Kidney injury and disease 105 Acute hepatic damage and liver failure 107 Acute leukaemia 109 Bacterial infection and other causes of leucocytosis 109 Eosinophilia 113 Lymphocytosis 115 Malaria 116 Neutropenia 119 Pancytopenia and leucoerythroblastic blood films 121 Neonatal emergencies 122 6 Self]assessment 125 Index 143

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Book SynopsisTable of ContentsPreface vii About the companion website ix 1 An introduction to haematopoiesis 1 2 The blood count in health and disease 15 3 Anaemia: general principles 23 4 Haemolytic anaemias 39 5 Disorders of globin synthesis 55 6 An introduction to haematological malignancies 71 7 Cellular and molecular investigations in haematology 79 8 Neoplastic disorders of myeloid cells 91 9 Neoplastic disorders of lymphoid cells 105 10 Plasma cell myeloma and other paraproteinaemias 121 11 Aplastic anaemia and pure red cell aplasia 131 12 Stem cell transplantation and cellular therapy 137 13 Haemostasis and bleeding disorders 147 14 Thrombosis and anticoagulant therapy 163 15 Blood groups and blood transfusion 173 Index 187

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Book SynopsisABC of Clinical Haematology An essential guide and introduction to the diagnosis, treatment and management of disorders across the breadth of clinical haematology Extensively revised, this 5th edition of ABC of Clinical Haematology covers all aspects of contemporary haematology, providing the basic science behind the disease and diagnostic aspects, along with up to date management. The text assumes little prior haematology knowledge, enabling clear understanding by non-experts, including medical students and nurses. Full colour illustrations and text boxes highlighting important learning points together enable more efficient reader comprehension. ABC of Clinical Haematology covers: Iron deficiency anaemia, macrocytic anaemia, hereditary anaemias, polycythaemia vera, essential thrombocythaemia, and myelofibrosis Chronic myeloid leukaemia, acute leukaemias, lymphoma, stem cell transplantation, cellular therapies, adult myelodysplastic syndrome, and myeloma Bleeding disorders, thrombosis, anticoagulation, and paediatric haematology, platelet disorders Amyloidosis, with focus on systemic light chain amyloidosis, and haematological emergencies New tests, treatments, and management solutions that are now available for certain conditions, especially common blood related disorders With contributions from leading experts in their respective fields, ABC of Clinical Haematology, Fifth Edition provides an ideal reference for primary care practitioners and other healthcare professionals working with patients who have blood related problems. About the ABC series The ABC series has been designed to help you access information quickly and deliver the best patient care, and remains an essential reference tool for GPs, junior doctors, medical students and healthcare professionals. Now offering over 80 titles, this extensive series provides you with a quick and dependable reference on a range of topics in all the major specialties. The ABC series is the essential and dependable source of up-to-date information for all practitioners and students in primary healthcare. To receive automatic updates on books and journals in your specialty, join our email list. Sign up today at www.wiley.com/emailTable of ContentsContributors iv Preface to the Fifth Edition v 1 Iron Deficiency Anaemia 1 Catherine Booth and Drew Provan 2 Macrocytic Anaemia 7 Samah Babiker and Nita Prasannan 3 The Hereditary Anaemias 13 Rachel Kesse- Adu 4 Polycythaemia Vera Essential Thrombocythaemia and Myelofibrosis 19 Anna L. Godfrey and Claire Harrison 5 Chronic Myeloid Leukaemia 25 Hugues de Lavallade 6 The Acute Leukaemias 31 Michael Austin and Bela Patel 7 Platelet Disorders 39 Marie A. Scully and John Paul Westwood 8 Adult Myelodysplastic Syndrome 47 Sally B. Killick 9 Myeloma and Other Plasma Cell Dyscrasias 53 Sally Moore and Karthik Ramasamy 10 Bleeding Disorders Thrombosis and Anticoagulation 59 Vickie McDonald 11 Lymphoma 65 Karen Stanley and David Wrench 12 Stem Cell Transplantation 81 Michelle Escebedo- Cousin and Kirsty Thomson 13 Cellular Therapies 87 Reuben Benjamin 14 Paediatric Haematology 91 John D. Grainger and Lianna Reynolds 15 Amyloidosis with a Focus on Systemic Light Chain Amyloidosis 101 Ayesha Shameem Mahmood 16 Haematological Emergencies 109 Vered Stavi and Igor Novitzky- Basso Index 119

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Book SynopsisThis broad and accessible introduction to the study of blood has been fully revised and updated to reflect advances in the field and in clinical practice, covering essential knowledge, from basic hematological physiology to blood disorders and their diagnosis and treatment.Trade Review“This book is an invaluable resource for medical students and health professionals wanting to consolidate and expand their knowledge of haematology.” (Kingbook73's Medical Ebook and Video Collection, 26 August 2014)Table of ContentsPreface to the fourth edition 6 Preface to the first edition 6 Glossary 7 Normal values 8 About the companion website 9 Part 1 Basic physiology and practice 1 Haemopoiesis: physiology and pathology 10 2 Normal blood cells I: red cells 14 3 Normal blood cells II: granulocytes, monocytes and the reticuloendothelial system 18 4 Normal blood cells III: lymphocytes 20 5 Lymph nodes, the lymphatic system and the spleen 23 6 Clinical assessment 24 7 Laboratory assessment 26 Part 2 Red cell disorders 8 General aspects of anaemia 30 9 Iron I: physiology and deficiency 33 10 Iron II: overload and sideroblastic anaemia 36 11 Megaloblastic anaemia I: vitamin B 12 (B 12) and folate deficiency – biochemical basis, causes 38 12 Megaloblastic anaemia II: clinical features, treatment and other macrocytic anaemias 40 13 Haemolytic anaemias I: general 42 14 Haemolytic anaemias II: inherited membrane and enzyme defects 44 15 Haemolytic anaemias III: acquired 46 16 Haemolytic anaemias IV: genetic defects of haemoglobin – thalassaemia 48 17 Haemolytic anaemias V: genetic defects of haemoglobin – sickle cell disease 52 Part 3 Benign disorders of white cells 18 Benign disorders of white cells I: granulocytes, monocytes, macrophages 54 19 Benign disorders of white cells II: lymphocytes, lymph nodes, spleen, HIV 56 Part 4 Haematological malignancies 20 Introduction to Haematological malignancy: basic mechanisms 58 21 General aspects of treatment 61 22 Acute leukaemia I: classification and diagnosis 64 23 Acute leukaemia II: treatment and prognosis 68 24 Chronic Myeloid Leukaemia (BCR-ABL1 positive) 70 25 Myelodysplasia (myelodysplastic syndromes) 72 26 Myeloproliferative disorders I: introduction 74 27 Myeloproliferative disorders II: polycythaemia rubra vera 76 28 Myeloproliferative disorders III: essential thrombocythaemia, primary myelofibrosis and systemic mastocytosis 78 29 Chronic lymphocytic leukaemia 80 30 Multiple myeloma and plasma cell disorders 83 31 Lymphoma I: introduction 86 32 Lymphoma II: Hodgkin lymphoma 88 33 Lymphoma III: non-Hodgkin lymphoma – aetiology and classification 90 34 Lymphoma IV: clinical and laboratory features of more common subtypes 92 35 Lymphoma V: treatment and prognosis 94 Part 5 Treatment and procedures 36 Bone marrow failure 96 37 Haematological effects of drugs 98 38 Stem cell transplantation 100 Part 6 Haemostasis 39 Normal haemostasis I: vessel wall and platelets 102 40 Normal haemostasis II: coagulation factors and fibrinolysis 104 41 Disorders of haemostasis I: vessel wall and platelets 106 42 Disorders of haemostasis II: inherited disorders of coagulation 108 43 Disorders of haemostasis III: acquired disorders of coagulation 110 44 Thrombosis and anti-thrombotic therapy 112 45 Anticoagulation 115 Part 7 Haematological aspects of tropical disease 46 Haematological aspects of tropical diseases 118 47 Haematology of pregnancy and infancy 120 Part 8 Blood transfusion 48 Blood transfusion I 122 49 Blood transfusion II 124 Appendix: cluster of differentiation nomenclature system 127 Index 129

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Book SynopsisPublisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.Hemostasis and Thrombosis as only Williams can cover itIN FULL COLOR!A Doodyâs Core Title for 2019! Featuring twenty-five clinically relevant chapters originally appearing in Williams Hematology, Ninth Edition â many carefully updated by the original authors to reflect the latest developments -- this concise, full-color resource delivers comprehensive and up-to-date coverage of hemostasis and thrombosis. The result of this unique compilation is a focused, timely resource that will be of particular value to advanced medical students who seeks a more detailed review of hematology than generally presented in second year medical school, medicine and pediatric resideTable of ContentsTable of ContentsChapter 1. Megakaryopoiesis and ThrombosisChapter 2. Platelet Morphology, Biochemistry, and FunctionChapter 3. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of HemostasisChapter 4. Control of Coagulation ReactionsChapter 5. Vascular Function in HemostasisChapter 6. Classification, Clinical Manifestations and Evaluation of Disorders of Hemostasis Chapter 7. ThrombocytopeniaChapter 8. Heparin-Induced ThrombocytopeniaChapter 9. Reactive ThrombocytosisChapter 10. Hereditary Qualitative Platelet DisordersChapter 11. Acquired Qualitative Platelet DisordersChapter 12. The Vascular PurpurasChapter 13. Hemophilia A and Hemophilia BChapter 14. Inherited Deficiencies of Coagulation Factors II, V, V+VIII, VII, X, XI, and XIIIChapter 15. Hereditary Fibrinogen AbnormalitiesChapter 16. von Willebrand DiseaseChapter 17. Antibody-Mediated Coagulation Factor DeficienciesChapter 18. Hemostatic Alterations in Liver Disease and Liver TransplantationChapter 19. Disseminated Intravascular CoagulationChapter 20. Hereditary ThrombophiliaChapter 21. The Antiphospholipid SyndromeChapter 22. Thrombotic MicroangiopathiesChapter 23. Venous ThrombosisChapter 24. Atherothrombosis: Disease Initiation, Progression, and TreatmentChapter 25. Fibrinolysis and Thrombolysis

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Book SynopsisA comprehensive series of multiple-choice questions and answers to help readers strengthen their knowledge of hematopathology and coagulation to prepare for their American Board of Pathology exams. All areas of the curriculum, from red blood cell count and coagulation disorders to hematopoietic neoplasms, are covered, and explanations are given to aid learning.Table of ContentsPreface; Part I. Non Neoplastic Hematology: 1. RBC disorders; Answers to chapter 1; Answers to chapter 1 (with explanations); 2. Non neoplastic WBC and platelet disorders; Answers to chapter 2; Answers to chapter 2 (with explanations); 3. Benign lymph node; Answers to chapter 3; Answers to chapter 3 (with explanations); Part II. Hematopoietic Neoplasms: 4. Myeloid neoplasms; Answers to chapter 4; Answers to chapter 4 (with explanations); 5. Mature B cell lymphomas, plasma cell neoplasms and Hodgkin lymphoma; Answers to chapter 5; Answers to chapter 5 (with explanations); 6. Mature T cell and NK cell neoplasms; Answers to chapter 6; Answers to chapter 6 (with explanations); Part III. Haemostasis and Coagulopathy: 7. Coagulation disorders; Answers to chapter 7; Answers to chapter 7 (with explanations).

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Book Synopsis

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Book SynopsisProvides a core knowledgebase for those with minimal exposure to hematologic molecular biology, fully revised and updated Molecular Hematology brings together the most up-to-date and reliable information on the molecular basis of major hematologic diseases. Edited and authored by leading experts in the field, this volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders. Concise, accessible chapters address key topics in modern hematology, such as lymphoma genetics, molecular coagulation, thrombophilia, pharmacogenomics, platelet disorders, hemophilia, anemia, and multiple myeloma. Chapters introduce and summarize specific hematologic diseases, explore the pathogenesis of the disorder, highlight new and emerging molecular strategies, and more. Now in its fifth edition, Molecular Hematology is fully revised to incorporate contemporary hematology research and practice. Entirely new chapters cover topic

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Book SynopsisThis new textbook has an international authorship and is a practical, up-to-date resource for clinicians responsible for the care of children with oncologic and malignant hematologic disease. Itis specifically designed for practicing oncologists and hematologists, pediatricians with an interest in childhood cancer and trainees seeking a systematic approach to these disorders. This new textbook has an emphasis on the visual presentation and ease of reading of contemporary and comprehensive information for children's cancers and contains detailed tables, fact boxes and illustrations. The textbook begins with an introduction to the general principles of the scientific foundation and treatment of childhood cancers and hematological malignancies. Separate sectionsare then devoted to descriptions of central nervous system tumors, hematological malignancies and solid tumors of childhood which encompass epidemiology, cellular and molecular biology, cancer genetics, immunology, pharmacologTrade Review“It is compact, concise, and easy to read and understand, and certainly a useful addition to the field.” (Doody's, 3 August 2012) "However, overall, this is a useful book, probably most useful for paediatricians who may be providing shared care for paediatric oncology patients, junior doctors on haematology/oncolgy ward." (The Bulletin of the Royal College of Pathologists, 1 July 2011)Table of ContentsContributors. 1 Introduction (Edward J. Estlin, Richard J. Gilbertson and Robert F. Wynn). Part I Central Nervous System Tumors of Childhood. 2 Low- and High-Grade Glioma (Ian F. Pollack). 3 Ependymoma (Thomas E. Merchant and Richard J. Gilbertson). 4 Embryonal Tumors (Amar Gajjar and Steven C. Clifford). 5 Pediatric Spinal Cord Tumors (Annie Huang, Ute Bartels and Eric Bouffet). 6 Pediatric Craniopharyngioma, Mixed Glioneuronal Tumors, and Atypical Teratoid/Rhabdoid Tumor (Adrienne Weeks and Michael D. Taylor). Part II Hematological Disorders. 7 Acute Lymphoblastic Leukemia (Robert F. Wynn). 8 Acute Myeloid Leukemia and Myelodysplastic Disorders (David K.H. Webb). 9 Non-Hodgkin’s Lymphoma (Angelo Rosolen and Lara Mussolin). 10 Hodgkin's Lymphoma (Wolfgang Dörffel and Dieter Körholz). 11 Histiocytic Disorders (Sheila Weitzman and R. Maarten Egeler). Part III Solid Tumors of Childhood. 12 Neuroblastoma (Sucheta J. Vaidya and Andrew D. J. Pearson). 13 Renal Tumors (Edward J. Estlin and Norbert Graf). 14 Soft Tissue Sarcoma (Gianni Bisogno and John Anderson). 15 Bone Tumors (Richard Gorlick, Martha Perisoglou and Jeremy Whelan). 16 Hepatic Tumors (Penelope Brock, Derek J. Roebuck and Jack Plaschkes). 17 Germ Cell Tumors (James Nicholson and Roger Palmer). 18 Retinoblastoma (Edward J. Estlin, François Doz and Michael Dyer). 19 Rare Tumors (Bernadette Brennan and Charles Stiller). Part IV Supportive Care, Long-Term Issues, and Palliative Care. 20 Supportive Care: Physical Consequences of Cancer and its Therapies (Bob Phillips and Roderick Skinner). 21 Psychosocial Needs of Children with Cancer and Their Families (Ged Lalor and Louise Talbot). 22 Late Effects in Relation to Childhood Cancer (Louise Talbot and Helen Spoudeas). 23 Palliative Care (Lynda Brook). 24 Clinical Trials Involving Children with Cancer – Organizational and Ethical Issues (Sue Ablett and Edward J. Estlin). Index. Colour plate.

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Book SynopsisMeeting the needs of patients while minimizing blood transfusions requires special expertise, precise monitoring and innovative techniques. This cutting-edge resource covers all the important clinical aspects of transfusion medicine in diverse clinical settings, with a special emphasis on alternatives to transfusion. Edited by a multidisciplinary team consisting of a transfusion specialist, an anesthesiologist and an intensive care specialist this book is endorsed by the Network for Advancement of Transfusion Alternatives. The contributors review the appropriate use of fluids and of blood products, and describe the latest treatment options available to decrease the need for allogeneic blood products including: Argon beam Cell saver Harmonic scalpel Normovolemic haemodilution Synthetic erythropoietin Antifibrinolytics Recombinant factor VIIa Advanced monitoring of hemostasis Intravenous iron Trade Review"It would be of great interest to students or practitioners in laboratory and/or transfusion medicine, anesthesiology, and surgery interested in alternatives to blood transfusion. The editors and authors are credible authorities in their fields." (Doody's, 9 September 2011) "The book provides the state of the art in blood transfusion management and I shall certainly be referring to it often as I continue to develop a blood conservation programme in my own hospital." (The Bulletin of the Royal College of Pathologists, 1 July 2011) Table of ContentsContributors List ix Part 1 History and Development of Transfusion Medicine 1 1 From Blood Transfusion to Transfusion Medicine 3Alice Maniatis Part 2 Allogeneic Blood Usage—Risks and Benefits 9 2 Allogeneic Blood Components 11Rebecca Cardigan & Sheila MacLennan 3 Current Information on the Infectious Risks of Allogeneic Blood Transfusion 21Alan D. Kitchen & John A. J. Barbara 4 Immunological Complications of Blood Transfusion 31Clare Taylor Cristina Navarrete & Marcela Contreras 5 Immunomodulation and Allogeneic Blood Transfusion 47Marloes Waanders Leo Van De Watering & Anneke Brand 6 Pathogen Inactivation of Blood Components 60Chris Prowse 7 The Benefits of Allogeneic Erythrocyte Transfusion: What Evidence Do We Have? 68Neil Soni & Benjamin Thomas Part 3 Volume Replacement 83 Section 1 Plasma and Albumin 85 8 Plasma and Albumin 87Philippe L. Baele Section 2 Crystalloids and Synthetic Colloids 109 9 Pharmacology of Intravenous Fluids 111Michael F.M. James 10 Crystalloids versus Colloids: The Controversy 119Hengo Haljamäe 11 Effects of Synthetic Colloids on Hemostasis 137Sibylle A. Kozek-Langenecker & Gisela Scharbert 12 Hydroxyethyl Starch and Renal Dysfunction 150Laurent Jacob Nicholas Heming & Bertrand Guidet 13 Choice of a Synthetic Colloid for Surgery 158Joachim Boldt 14 Choice of Colloid for Intensive Care Patients 168Yasser Sakr & Yalcin Inel 15 Hypertonic Saline Solutions for the Initial Treatment of Patients with Traumatic Injuries 179Charles E. Wade & Michael A. Dubick 16 Hyperchloremic Acidosis 194Edward Burdett & Andre Vercueil Part 4 Tolerance of Anemia 203 17 Basic Principles of Oxygen Transport and Calculations 205Jean-Louis Vincent Pongdhep Theerawit & Davide Simion 18 Assessment of Tissue Oxygenation 210Michael Piagnerelli Ann Dierick & Philippe Van der Linden 19 Tissue Oxygenation and Blood Transfusion 218Stefan Suttner & Joachim Boldt 20 Anemia and Cardiovascular Disease 229Antonis S. Manolis Spyridon Koulouris Kostas Triantafyllou Dimitris Sakellariou Sokratis Pastromas & Helen Melita Part 5 Perioperative Hemostasis 253 21 Monitoring of Hemostasis in the Perioperative Setting 255Sibylle A. Kozek-Langenecker & Eva Schaden 22 Antifibrinolytics in Open-Heart Surgery 267Wulf Dietrich 23 Efficacy and Safety of Recombinant Activated Factor VII to Control Bleeding in Nonhemophiliac Patients 278Jean-François Hardy Sylvain Bélisle & Philippe Van der Linden Part 6 Transfusion Triggers 293 24 Role of Hemoglobin/Hematocrit 295Kristine J. Guleserian Hae W. Kim Bruce Pearce Arkadiy Pitman & A. Gerson Greenburg 25 Calculation of Blood Loss 303Mark E. Brecher 26 Management of Massive Transfusion 313Jean-François Hardy & Marc Samama Part 7 Alternatives to Allogeneic Blood Transfusion 329 Section 1 Pharmaceutical Approaches 331 27 Iron Deficiency: Causes Diagnosis and Management 335Manuel Muñoz José Antonio García-Erce & Elvira Bisbe 28 Current Status of Perisurgical Erythropoietin Therapy 350Lawrence T. Goodnough 29 Erythropoietin and Iron Therapy in Patients with Renal Failure 357Lucia Del Vecchio & Francesco Locatelli 30 Hemoglobin-based Blood Substitutes 368G. Deby-Dupont Bernadette Remy & Maurice Lamy 31 Perfluorocarbon Emulsions 380Pedro Cabrales Section 2 Surgical Techniques 389 32 Minimally Invasive Cardiac Surgery: Impact on Blood Loss and Transfusion 391He Tao & Fraser Rubens 33 Adjunctive Strategies to Impact Blood Transfusion in Cardiac Surgery 408L. Ressler & Fraser Rubens Section 3 Anesthetic Techniques 419 34 Anesthetic Techniques to Reduce Blood Loss 421Dafydd Thomas 35 Controlled Hypotension Decreases Blood Transfusion Requirement: Fact or Fallacy? 430Richard P. Dutton 36 Acute Normovolemic Hemodilution 439Javad Bidgoli & Philippe Van der Linden 37 Hyperoxic Hemodilution 450Jens Meier Konrad Messmer & Oliver Habler 38 Intraoperative and Postoperative Cell Salvage 458Ernil Hansen & Hans Gombotz Section 4 Special Settings 475 39 Anemia and Red Blood Transfusion in Critical Care 477Tim Walsh 40 Red Blood Cell Transfusions and Alternatives to Treat the Anemia of Prematurity 490Ronald G. Strauss 41 Transfusion Alternatives in Orthopedic Surgery 498Manuel Muñoz José Antonio García-Erce & Jorge Cuenca 42 Transfusion Alternatives in Obstetrics 509Christian Breymann Part 8 Legal and Ethical Issues in Transfusion Medicine 521 43 Ethical Aspects of Informed Consent: American Models 523Ronald E. Domen 44 Blood Transfusions Jehovah’s Witnesses and the American Patients’ Rights Movement 531Charles H. Baron Part 9 Cost Issues 557 45 The Cost and Cost-Effectiveness of Allogeneic and Autologous Blood 559Brian Custer 46 Autologous Blood Predonation in Cardiac Surgery 569Wulf Dietrich 47 Cost-Effectiveness of Pharmacological Alternatives 575Dean Fergusson & Brian Hutton Index 581

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