Transplant surgery Books

Book SynopsisA beautifully written and compelling memoir of a largely unexplored area of medicine: transplant surgery.Leading transplant surgeon Dr Joshua Mezrich creates life from loss, moving organs from one body to another. In this intimate, profoundly moving work, he examines more than one hundred years of remarkable medical breakthroughs, connecting this fascinating history with the stories of his own patients.Gripping and evocative, How Death Becomes Life takes us inside the operating room and presents the stark dilemmas that transplant surgeons must face daily: How much risk should a healthy person be allowed to take to save someone she loves? Should a patient suffering from alcoholism receive a healthy liver? The human story behind the most exceptional medicine of our time, Mezrich's riveting book is a poignant reminder that a life lost can also offer the hope of a new beginning.Trade ReviewPart memoir and part historical account of the extraordinary pioneers who believed that people could berepaired and revived as the sum of their working parts... Moving * Financial Times *An outstanding memoir by a transplant surgeon who combines an autobiography and operating room dramatics with an equally engrossing history of his profession... this [medical memoir] ranks near the top [of the genre], in a class that includes arguably the best, Henry Marsh's Do No Harm * Kirkus Reviews *Monumental and enthralling. * New York Journal of Books *Fascinating... Compelling stories about an area of medicine shrouded in mystery. * Stephen Westaby *A beautifully written insight into an extraordinary area of medicine and a fascinating career. Heartbreaking and life-affirming in equal measure, it has all the makings of a classic. * Dr Max Pemberton, columnist and author of Trust Me, I'm a (Junior) Doctor *Table of Contents1: A Perfect Organ 2: Puzzle People 3: The Simple Beauty of the Kidney 4: Skin Harvest 5: Kidney Beans: Making Kidney Transplant a Reality 6: Open Heart: The Invention of Cardiopulmonary Bypass 7: Hearts on Fire: Making Heart Transplant a Reality 8: Sympathy for the Pancreas: Curing Diabetes 9: Prometheus Revisited: Liver Transplants and Thomas Starzl 10: Jason: The Secret Is to Live in the Present 11: Lisa and Herb: Should We Do Liver Transplants for Alcoholics? 12: Nate: The Selection Meeting, or Who Gets an Organ and Why? 13: Michaela: We Are All the Same on the Inside 14: As They Lay Dying 15: Healthy Donors: Do No Harm 16: Complications 17: Xenotransplantation: From One Species to Another 18: So, You Want to Be a Transplant Surgeon?

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Book Synopsis''Compelling'' Christopher Hart, The Sunday Times''A fascinating book'' Daily Mail_______________________________________________________________We think of transplant surgery as one of the medical wonders of the modern world -- but it''s a lot older than you think. As ancient as the pyramids, its history is even more surprising. In Spare Parts, cultural historian Paul Craddock takes us on a fascinating journey and unearths incredible untold stories, from Indian surgeons regrafting lost noses in the sixth century BC, to the seventeenth century architect who helped pioneer blood transfusions, to the French seamstress whose needlework paved the way for kidney transplants in the early 1900s.Expertly weaving together philosophy, science and cultural history, Spare Parts explores how transplant surgery has constantly tested the boundaries between human, animal and machine. It shows us that the history -- and future -- of transplant surgery is tied up with questions not only about who we are, but also what we are, and what we might become._______________________________________________________________''By turns delightful and disturbing . . . A thoroughly engrossing read that I couldn''t put down'' LINDSEY FITZHARRIS, author of The Facemaker and The Butchering Art''Spare Parts is a fascinating read filled with adventure, delight and surprise'' RAHUL JANDIAL, surgeon and author of Life on a Knife''s Edge''This is a joyful romp through a fascinating slice of medical history'' WENDY MOORE, author of The Knife ManTrade ReviewA fascinating book * Daily Mail *Compelling -- Christopher Hart * The Sunday Times *The charm of Spare Parts comes from situating these landmarks in a wider history of ideas * Spectator *A thrilling and often terrifying ride through transplantation and the theories and techniques that made it possible . . . tantalizing -- Robert Sullivan * The New York Times *Anyone interested in the history of surgery will find much to amaze and startle in Paul Craddock's Spare Parts: A Surprising History of Transplants * Independent *Excellent . . . Much has been written about this subject, but with Spare Parts Paul Craddock has achieved something unique: a serious, entertaining and thoroughly researched work that usefully sets the history of transplantation in the context of the evolution of ideas about the human body -- Thomas Morris * TLS *Craddock combines meticulous scholarship with wry wit in lucid prose which is all the more powerful for being understated . . . Spare Parts is a triumph * Roger Kneebone, author of 'Expert' *I read Spare Parts with my mouth open, my eyes popping and my brain fizzing. It's a fascinating exploration of just how far humans will go to stay on the right side of death. I can't think of any other book whose pages will make you laugh, gasp, grimace and wince. Spare Parts is a triumph of medical story-telling * Michael Brooks, author of 'The Quantum Astrologer's Handbook' and 'Science(ish)' *This is a fascinating and sure-footed exploration of the medical, historical and mythological landscape in which humans use parts from each other to make themselves whole. With compassion and insight, Paul Craddock elucidates vital questions about what it means to be human and to realise our dreams of survival * Dr Emily Mayhew, author of 'Wounded' and 'The Four Horsemen' *This is a captivating and absorbing read that surprises on every page whether it be from prosthetic noses of the 16th Century to modern day bio-printing and stem cell technology * Professor Dame Sue Black, author of 'All That Remains' *Paul Craddock's book is a veritable tour de force, a tantalising journey through human efforts in understanding science, medicine, personal beliefs and ourselves over the past centuries . . .Packed with stories which bring to life the personalities, the heroes and villains, and, with benefit of hindsight, the sometime frankly incredulous ideas, we get a unique and inspiring tapestry of events . . . A thoroughly good read * Barry Fuller, Professor of Surgical Sciences at UCL Medical School *This compelling and impeccably researched history of transplant surgery puts you right at the heart of the gruesome action. An enthralling read * Richard Hollingham, author of 'Blood and Guts' *A riveting journey through the story of anatomical alchemy, Spare Parts is a fascinating read filled with adventure, delight and surprise * Rahul Jandial, surgeon and author of 'Life on a Knife’s Edge' *Spare Parts is such a pleasure to read, filled with so many fascinating characters and stories that seem almost too crazy to be real; I found myself chuckling, shaking my head and yet proud to be a part of this field. This is a must read for anyone that has ever been touched by transplantation or the gift of donation, a book that makes us proud of our macabre past and excited about what can only be a limitless future * Josh D Mezrich, author of 'How Death Becomes Life' *Stuffed with eccentric characters and questionable experiments, this is a joyful romp through a fascinating slice of medical history * Wendy Moore, author of 'The Knife Man' *A perfect blend of history, science and humanity on a thrilling journey around old and new parts of the human body * Matt Morgan, author of 'Critical' *Spare Parts uncovers the gripping birth of sharing body parts, and significantly, tells us all of our current 'good ideas and innovations' have been thought of and tested already - we are simply adding to the mix. This visceral book offers us an unparalleled historical treatise, as the world of complex transplantation continues to unravel and change * Daniel Saleh, award-winning consultant plastic and reconstructive surgeon *With curious and clinical precision ... Craddock raises questions about how we relate to one another, what stories we choose to privilege and who gets to tell them * Irish Times *By turns delightful and disturbing, even the most seasoned of medical history buffs will be astonished by Spare Parts. A thoroughly engrossing read that I couldn't put down. Hit that order button -- you won't regret it * Lindsey Fitzharris, author of The Butchering Art *An accessible and wide-ranging account . . . Amid the toe-curling descriptions of vivisected dogs and doomed trial runs at human-to-human tooth transplants are hopeful and inspiring accounts of how farmers and embroiderers shared their knowledge with medical practitioners . . . Thoroughly researched and appealingly digressive, this fascinating medical and cultural history sheds light on what it means to be human * Publishers Weekly *

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Book SynopsisTable of ContentsHyponatremia in Cirrhosis Hepatorenal Syndrome: Pathophysiology Hepatorenal Syndrome: Definitions, Diagnosis, and Management Glomerular Disease in Liver Disease The Interplay Between Nonalcoholic Fatty Liver Disease and Kidney Disease Polycystic Kidney/Liver Disease Kidney Replacement Therapy in Patients with Acute Liver Failure and End-Stage Cirrhosis Awaiting Liver Transplantation Peritransplant Renal Dysfunction in Liver Transplant Candidates Pros and Cons of the Safety Net Rule for Prioritization of Liver Transplant Recipients Who Receive Liver Alone Transplant but Develop End-Stage Renal Disease Kidney Allocation Issues in Liver Transplantation Candidates with Chronic Kidney Disease and Severe Kidney Liver Injury The Use of Hepatitis C Virus-Positive Organs in Hepatitis C Virus-Negative Recipients Simultaneous Liver-Kidney Transplantation Chronic Kidney Disease After Liver Transplantation

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Book Synopsis“[A] remarkable journey.” —The TelegraphThe incredible life story of legendary cardiac surgeon and scientist Magdi Yacoub, an outsider who succeeded against the odds Veteran journalists Simon Pearson and Fiona Gorman follow the remarkable life of heart surgeon Magdi Yacoub from his formative years in Egypt, through spectacular success at Cairo University, to his long and distinguished career in Britain. Although at times he clashed with the medical establishment in London, Yacoub pioneered great advances in heart surgery. He was knighted in 1992, and in 2014, he was awarded the highest honor in the gift of the Queen, the Order of Merit.Written with unprecedented access and drawing on extensive interviews and research, the biography recounts how Yacoub transformed the treatment of children with congenital heart disease. He performed some of the first heart transplants in Britain and the first heart-lung transplants in Europe. At London’s Harefield Hospital, he created the greatest heart transplant center in the world. Among his patients are men and women who are still thriving more than thirty-five years after he gave them new hope. This story is also about science, the development of new medical techniques, and a deeper understanding of how the human body works. Today, at an age when most people have long since retired, Yacoub is still pushing the boundaries of scientific understanding and surgical know-how. He is also taking heart surgery to places that until now have had little access to cardiac treatment, developing centers of excellence across Africa, including in Egypt, where his hospital in Aswan has an international reputation, and a new center is rising in Cairo.Yacoub’s life is one of triumph and tragedy, success and failure, fierce criticism and high praise—it is also an enthralling journey through the worlds of scientific research and medical politics and ethics at the highest levels.Trade Review“Chronicling his remarkable journey from Belbeis, an ancient fortress city on the Nile delta, to becoming one of the world’s most famous Egyptians . . . the book not only lays bare his surgical successes but also the challenges he faced along the way.”—The Telegraph"The reason that he has finally consented to an authorised biography now after all these years is not, he stresses, out of self-aggrandisement, but in the hope that it will inspire others to follow in his footsteps."—The National"His legacy is one of innovation and saved lives. . . . an outsider who went on to have a career of firsts."—Channel 4 News"Whether or not you are interested in the medical field, Yacoub’s tale will impassion anyone striving to create a more just and honourable society."—The New Arab"This is a story of a life well lived. Sir Magdi Yacoub has transformed medical practice and improved the lives of millions of people. He did this with intellectual creativity, determination, and a deep commitment to serving humanity."—Minouche Shafik, President, Columbia University“From humble beginnings as he followed his surgeon father across Egypt, to achieving the highest honors in the UK, Magdi Yacoub’s story exemplifies the values of hard work, innovation, and humanity. His passion for science and his unrivaled surgical wizardry are only surpassed by his core belief that every human life holds equal value. This book will undoubtedly inspire generations of young people all around the world to fulfill their most ambitious dreams.”—Valentin Fuster, Physician in Chief, Mount Sinai Hospital"This book recounts how a brilliant and determined young Egyptian became a great pioneer and global champion of cardiac surgery. Through his skills in the operating theater and his indefatigable energy he’s directly saved thousands of lives. And through his intensive commitment and compelling advocacy of hospitals and research his Chain of Hope charity has saved many more—especially in Africa. Magdi Yacoub’s immense achievements richly deserve honor and celebration, and this fine book tells us all why."—Martin Rees, author of If Science is to Save Us"Amazing stories"—Alhurra"An unconventional biography"—Groks Science ShowPRAISE FOR MAGDI YACOUB:"Magdi has changed our definition of what is possible."—Gordon Brown, former UK Prime Minister"The world’s leading cardiac surgeon"—The Sunday Times"Renowned heart specialist Professor Sir Magdi Yacoub"—The Guardian “Recognized as one of the great pioneers of heart transplant surgery”—BBC Radio"The Leonardo da Vinci of cardiac surgery"—Peter Alivizatos, MDTable of ContentsForeword Dame Mary ArcherAcknowledgments Introduction1. Plymouth, Southwest England, 19832. Early Years3. Growing Ambitions4. The Road Ahead5. Lord Brock6. Trial by Sherry7. The Man Who Dared8. New Horizons9. So Long, Marianne 10. The American Way11. The France12. On the Shoulders of Giants13. A Promise Fulfilled14. Pushing Boundaries15. Magic Hands16. The Boy and the Baboon17. Legal Aid18. Give Them Sunshine 19. An Unexpected Gift20. Enemies at the Gate21. The Tide Turns22. Through the Lens23. Lives Transformed24. Meanwhile, at Home . . . 25. Heart-Lung Transplants26. A Question of Ethics27. Deliverance28. The Triumph of Science 29. Held to Account30. The Domino 31. Greek Odyssey 32. Spreading the Word33. The Ross Procedure34. Signs of Success35. Chain of Hope36. Dr. Zhivago37. The Queen of Hearts38. The Generous American39. Peer Review40. The Reluctant Pensioner 41. A Kindred Spirit42. Into Africa43. Good Morning Egypt44. The Girl with Two Hearts45. Taking the Podium46. Pain and Loss47. Haile’s Story48. Universally Acknowledged 49. Capital Investment EpilogueSources and NotesBibliographyIndex

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Book SynopsisThis Open Access Second Edition textbook, endorsed by the EBMT, provides adult and pediatric nurses with a full and informative guide covering all aspects of transplant nursing including a new chapter dedicated to cellular therapy, nursing implications and care. This book takes the reader from basic principles to advanced concepts on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This second edition specifically intended for nurses, complements the EBMT Handbook, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational reference tool in its own right.This title is designed to develop the knowledge of nurses in transplantation. It is the only one of its kind written by nurse experts, specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes to patient care in this area. This new volume presents updated content that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to refresh their knowledge. This Textbook is open access under a CC BY 4.0 license.Table of ContentsFront Matter• JACIE and Quality Management in HSCT: Implications for NursingCarole Charley, Aleksandra Babic, Iris Bargalló Arraut, Ivana Ferrero• HSCT: How Does It Work?Letizia Galgano, Daphna Hutt• Donor SelectionMairéad Níchonghaile• Transplant PreparationCaroline Bompoint, Alberto Castagna, Daphna Hutt, Angela Leather, Merja Stenvall, Teija Schröder et al.• Cell Source and ApheresisAleksandra Babic, Eugenia Trigoso• Principles of Conditioning Therapy and Cell InfusionSara Zulu, Michelle Kenyon• Cell therapy, nursing implications and careProposed Lead Rose Ellard (co authors Michelle Kenyon, John Murray, Daphna Hutt)• BMT Settings, Infection and Infection ControlJohn Murray, Iris Agreiter, Laura Orlando, Daphna Hutt• Transplantation Through the GenerationsAlberto Castagna, Lisa Mcmonagle, Corien Eeltink, Sarah Liptrott• Early and Acute Complications and the Principles of HSCT Nursing CareElisabeth Wallhult, Barry Quinn• Supportive CareS. J. van der Linden, M. E. G. Harinck, H. T. Speksnijder, Teija Schröder, Ien Schlösser, Vera Verkerk et al.• Graft-Versus-Host Disease (GvHD)John Murray, Jacqui Stringer, Daphna Hutt• Graft Versus Tumour EffectMairéad NíChonghaile• Engraftment, Graft Failure, and RejectionDaphna Hutt• Late Effects and Long-Term Follow-UpMichelle Kenyon, John Murray, Barry Quinn, Diana Greenfield, Eugenia Trigoso• Nursing Research and Audit in the Transplant SettingCorien Eeltink, Sarah Liptrott, Jacqui Stringer

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Book SynopsisIn December, 1966, two patients dying of months after the transplants had been per­ uremia as a result of diabetic kidney disease formed.Table of Contents1. Experimental Pancreas Transplantation.- 2. Indications for Pancreas Transplantation.- 3. Pancreas Harvesting and Preservation Techniques.- 4. Anesthesia Management.- 5. Surgical Techniques.- 6. Cadaver Transplant Results.- 7. Living Related Pancreas Transplantation.- 8. Clinical Posttransplant Followup.- 9. Endocrine and Metabolic Response: Effect of Pancreas Transplantation on Diabetes Mellitus and Its Secondary Complications.- 10. Complications.- 11. Immunosuppression.- 12. Diagnosis and Management of Rejection.- 13. Pathology of Pancreatic Transplants.- 14. Duct-Occluded Pancreas Transplants.- 15. Bowel-Drained Pancreas Transplants.- 16. Urinary-Drained Pancreas Transplants.- 17. Future Prospects of Pancreas Transplantation.

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Book SynopsisThis book presents a view of the current environment of organ donation and transplantation after cardiac death in China, including legal and ethical aspects of cardiac death, assessment and management of potential organ donor, quality evaluation and machine perfusion of organ, as well as immunology, imaging and pathology related to transplantation from cardiac death donors. Since 2015, voluntary donation has been announced as the only legitimate venue for organ transplant in China. As cardiac death is adopted in China, the donation mode is different from those in other countries where brain death is adopted. It offers transplant surgeons and physicians valuable information on optimal practice proposal for organ donation after cardiac death in China.Table of Contents1 Legal, moral, and ethical issues related to cardiac death donation 2 Current situation of organ donation after cardiac death in china 3 Cardiac death donor evaluation and management 4 Organ procurement, quality evaluation and perfusion in cardiac death donation 5 Liver transplantation from cardiac Death Donors 6 Kidney transplantation from cardiac death donors 7 Lung transplantation from cardiac death donors 8 Pancreas and Islet Transplantation from Cardiac Death Donors 9 Multiple organ transplantation from cardiac death donors 10 Immunosuppressive strategies in transplantation using cardiac death donors 11 Ischemia and reperfusion injury in organ transplantation from cardiac death donors 12 Imaging related to transplantation from cardiac death donors 13 Pathological evaluation of DCD donor organs 14 Further Development of Organ Transplantation form Cardiac Death Donors in China

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Book SynopsisKidney transplantation has revolutionised the treatment of end-stage renal failure. Not only does it offer the best hope for complete rehabilitation, but it has also proved to be the most cost-effective of all treatment options, including dialysis. The surgical techniques involved have been mastered for half a century and are now considered routine. Nevertheless, this should not prevent us from appreciating the range and complexity of the issues surrounding kidney transplantation. This book examines the latest research in this field including rejection.

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Book SynopsisIn recent years, transplantation immunology has evolved as a distinct field founded on the recognition that rejection of a transplanted organ or tissue is mediated by immune mechanisms in the host responding to antigens in the donor tissue. Included within the scope are T cell immunity; Antigen presentation; Alloreactivity; Pancreas and islet cell transplantation; Allogeneic bone marrow transplantation Models of tolerance induction; Xenotransplantation and The swine leukocyte antigen (SLA) complex. This book gathers the latest research in the exciting new field of transplantation immunology.

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Book SynopsisThe issue of living organ donation is important because it represents one important set of possibilities for balancing the needs of people seeking organs with one another, and with the needs of potential organ donors. On one side of the balance, the drive to increase the supply of transplantable organs is fueled by people awaiting organ transplants. They are, in a sense, competing with one another on waiting lists for potentially life-saving scarce resources. On the other side of the balance, the drive to ensure that the transplant system is ethical and equitable precludes some mechanisms that would increase the supply of transplantable organs. Some options that have been rejected to date in the United States include paying healthy persons to donate their organs, and mandating that transplantable organs be harvested from all cadavers. To maintain the most ideal balance for the organ transplantation system, Congress may now wish to clarify whether certain new types of living organ donation should be adopted to increase the supply of transplantable organs, or prohibited for ethical and/or equitable reasons.

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Book SynopsisClinical transplantation is still in the infancy stage with less than 60 years history. Despite recent successes, there are still several unresolved problems. This book tries to tackle some of these problems such as organ shortage, live donation, expanding the donor pool, ethical and legal issues regarding brain death concepts, the consent for donation process, and the use of human tissue for transplantation. The diversity of authors with different backgrounds such as physicians, philosophers, and ethicists, makes this book unique. The book tries to comprehensively discuss different issues from different angles that transplantation faces today. This book has 12 chapters discussing a wide variety of topics related to organ donors and donation.

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Book SynopsisThis book brings together researchers from three different continents who present different perspectives on the complex issue of organ donation. Several important authors have contributed to this edited book on organ donation discussing the phenomenon from different aspects, particularly the psychological, medico-legal, religious and communications perspectives. Some of the authors have not only studied these questions academically, but they themselves are live organ donors or organ recipients as well. The chapters by Cole, Camilleri-Zahra, Schweda and Wolhke, Siegel, Anker and Jansen give importance to the voice of organ donors, recipients and their families. They discuss the dilemmas which donors, recipients and their families face when they come to learn that a family member needs an organ transplant, and the subsequent difficult decisions that have to be made by the recipients, possible donors and family members. The phases before and after the donation of organs are as important as the donation itself. Fear, guilt and other strong emotions are intrinsic to the donation process both in live donation as well as in cadaveric donation. The psychological and health challenges presented by organ donation, discussed by Lauri, Maloney, Walker and Charlton, Shanteau and Hyde, are compounded by legal, religious and cultural issues, which will also be discussed in different chapters of the book by Ellul, Borg and Reinhart. Finally, the chapters by Alvaro, Feeley and Yang discuss how the media can influence and inform public attitudes towards organ donation and discuss how it can help increase the number of organ donors. This book is meant for those who, in some way, come in contact with people who need an organ transplant and those who have to help people come to reach informed decisions.

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Book SynopsisOrgan transplantation has revolutionized the treatment for end-stage organ failure. Immunosuppression is still a major approach currently used in the prevention and treatment of allograft rejection. Both editors Dr. Chen and Dr. Qian have been contributing to preclinical evaluation of immunosuppressants for more than 25 years in North America. Experts from the United States, Canada, the United Kingdom, China, Japan, Germany, Sweden, Hungary and Brazil contributed 23 chapters to this book, providing details of immunological basis in transplantation. They also describe six classes of immunosuppressive agents (calcineurin inhibitors, mTOR inhibitors, JAK-STAT inhibitors, antiproliferative agents, costimulation blockers and corticosteroids), as well as ischemia/reperfusion injury treated agents. Additionally, the new development of cell therapy in the induction of transplant tolerance is introduced. This book provides many important references for the research direction of novel immunosuppressants. Readers that will find this book useful include transplant physicians, surgeons, nurses, immunologists, pharmacologists, pharmacists, medical students, residents and trainees in transplantation.

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Book SynopsisTransplanting hands -- a model of composite tissue grafting -- began in Lyons in November 1998 with the transplant of one hand and then, in January 2000, of two, both with the support of the Mérieux Foundation. Advances in immunosuppression made possible some unusual transplants of tissue, such as bones, knee-joints, femurs and larynx. From these stemmed the first attempts to transplant hands. This book looks at the long-term results of reattaching hands that have been accidentally amputated. It reviews all the problems -- technical, immunological, nervous, functional and psychological -- that surgeons encountered during and after the transplants. Surgeons, transplant experts, immunologists, dermatologists, psychiatrists, neurophysiologists, physiotherapists and re-education experts will also find here answers to their ethical and legal questions about removing tissue from donors, as well as information about composite tissue grafts in plastic and reconstructive surgery.

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Book Synopsis‘Gripping … so powerfully emotional that at times I had to put it down to wipe my eyes’Mail on Sunday ‘How do you say thank you to someone for giving you their heart? It is the greatest gift a person can ever give.’Trade Review‘Gripping … so powerfully emotional that at times I had to put it down to wipe my eyes’Mail on Sunday

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Book Synopsis1. The Early Surgeon-Anatomists.- 2. Physiology of the Exocrine Pancreas.- 3. The Endocrine Pancreas.- 4. Acute Pancreatitis.- 5. Chronic Pancreatitis, Including Pancreatic Lithiasis.- 6. Pancreatic Cysts, Pseudocysts, and Cystic Tumors.- 7. Trauma to the Pancreas.- 8. Congenital Anomalies.- 9. Tumors of the Ampulla of Vater and Pancreas (Non-Islet Cell).- 10. Treatment of Pancreatic and Ampullary Cancer.- 11. Progress in the Diagnosis of Pancreatic Diseases.- 12. Transplantation of the Pancreas and Islet Cells.- 13. The Lessons of History and Their Application to the Future.- Appendix: Notes on the Development of Pancreatology: Progress in Communications and Related Professional Societies.- Name Index.Trade ReviewFrom the reviews: "Although this book focuses on the history of the pancreas, it is a fascinating retreat into many other aspects of the history of medicine. John Howard and Walter Hess have spent their professional lives as academic pancreatic surgeons. Their book is the culmination of a prodigious effort to bring together a literature that begins with the Greek anatomist and surgeon Herophilus, who first described the pancreas around 300 b.c., and ends with the modern-day physicians and scientists who continue to expand our knowledge of the pancreas. History books can sometimes be a dull catalogue of events. Howard and Hess have made the journey personal with their insights into each investigator and into the ways in which various discoveries were made. Many of these discoveries were not focused efforts to understand the pancreas but observations made serendipitously. We are also treated to glimpses into the lives of many famous people, some of whom are well known for their discoveries outside the study of the pancreas but who also provided new knowledge of the anatomy and function of the pancreas. This well-organized book begins with early observations of the anatomy of the pancreas and accounts of the early experiments conducted to determine its function. We are brought from one of the first descriptions of the pancreas, as a "cushion of the stomach and pad supporting the vessels," to the discovery of the pancreatic duct by Johann Georg Wirsung in 1642. Wirsung made this discovery when he was a medical student in Padua, Italy, where he performed the autopsies before his mentor, Johann Wesling, presented the demonstration-lectures to the public in the anatomy theater. The next year, Wirsung was assassinated. His mentor, Wesling, was accused of the crime, the motive for which was rumored to be jealousy, but was eventually acquitted. Such vignettes add spice to the history of these discoveries and offer insight into the people who had a role in the history of knowledge about the pancreas and the times in which they lived. The studies that led to the determination of the function of the exocrine pancreas include those of Johann Conrad Brunner, who examined the effect of ligation of the pancreatic duct in dogs, the work of others who determined the acidity of pancreatic juice by tasting it, and Tiedemann and Gmelin's identification of the role of pancreatic juice and bile in digestion. Subsequent chapters focus on the history of acute and chronic pancreatitis, the discovery of the pancreatic islets and their relation to diabetes, and the identification of various tumors specific to this gland. The development of interventional approaches is presented in detail, including the first endoscopic retrograde cholangiopancreatography in 1965 by Rabinov and Simon, radiologists at Boston's Beth Israel Hospital, and the Whipple procedure in 1934 by Allen Whipple at the Columbia-Presbyterian Medical Center in New York. Many medical history books would stop at this point. This book, however, continues the journey into the present, bringing us up to date on contemporary researchers, new surgical procedures including islet-cell transplantation, and recently discovered genes. Although I initially found the size of this textbook daunting, the book is easy to read. This is in part owing to the fascinating portrayal of each of the major players who participated in developing our present understanding of the pancreas. It also reflects the authors' understanding of the history of medicine itself -- especially how discoveries were made before the era of high technology. This book will benefit not only anyone interested in the pancreas and the gastrointestinal tract, but also readers who want insights into the history of medicine." (Steven D. Freedman, M.D., Ph.D. in the New England Journal of Medicine, September 2003) "History Of The Pancreas creates a layered timeline meant to record the major discoveries surrounding the organ … . In sum, this treatise serves to outline the pancreas for clinicians and surgeons who now can use the information to formulate better approaches to patient treatment." (John Aiello, The Electric Review, January/February, 2009)Table of ContentsForeword. Preface. Acknowledgments. About the Authors. 1. The Early Surgeon-Anatomists. 2. Physiology of the Exocrine Pancreas. 3. The Endocrine Pancreas. 4. Acute Pancreatitis. 5. Chronic Pancreatitis, Including Pancreatic Lithiasis. 6. Pancreatic Cysts, Pseudocysts, and Cystic Tumors. 7. Trauma to the Pancreas. 8. Congenital Anomalies. 9. Tumors of the Ampulla of Vater and Pancreas (Non-Islet Cell). 10. Treatment of Pancreatic and Ampullary Cancer. 11. Progress in the Diagnosis of Pancreatic Diseases. 12. Transplantation of the Pancreas and Islet Cells. 13. The Lessons of History and Their Application to the Future. Appendix: Notes on the Development of Pancreatology: Progress in Communications and Related Professional Societies. Index of Persons. Index of Terminology.

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Book SynopsisEvery day, newspapers and television news programs present stories on the latest controversies over healthcare and medical advances, but they do not have the space to provide detailed background on the issues. This book provides an overview of the most controversial areas of healthcare.Trade Review"The first section of this book by Petechuk is titled Overview, but its four chapters, which cover history, organ procurement, organ allocation, and advances in transplantation, are all heavily imbued with ethical concerns. The six chapters of section 2, Controversies and Issues Relating to Transplantation, focus very specifically on the ethical issues of buying and selling organs, organ allocation, xenotransplantation, living donors, stem cell transplantation and research, and face transplants. An appendix of primary source documents provides a few brief government documents on various issues. The time line (in an appendix) reveals that the concept of organ transplantation existed as long ago as 400 BCE. A two-page glossary provides greater accessibility for readers without any health science knowledge. The bibliography is current, with entries as recent as 2005. A list of organizations and Web resources completes the text. This is a useful resource....Recommended. Lower-level undergraduates, two-year technical program students, and general readers." - Choice"Medical writer Petechuk explains all the sides of the issues for the informed general reader and beginning students, giving a brief history and describing organ procurement as an example of supply and demand, fair organ allocation, and future advanced anticipated, buying and selling organs, prioritizing potential recipients, animal use and infectious disease, living donors, stem cell transplantation, and the ethics behind face transplants. References given here include annotated primary source documents, a timeline, a glossary, and a list of further reading." - SciTech Book News

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Book SynopsisLiver Transplantation, Part Three: Time for Surgery is a step-by-step guide to the experience of liver transplant surgery. It guides you right through the process, from receiving the call that your new liver is ready, through surgery, to recovery and discharge. With easy-to-understand language and vibrant illustrations, readers will learn what to expect during the surgery and how to prepare for the recovery process. This book is the third in a series on Liver Transplantation which, when used together, guides readers through the entire experience of having a liver transplant. Key facts and details about the surgery, including how long it takes and what happens during the procedure are included, to prepare and comfort you when it is time for your surgery. This informative and enjoyable book is part of the series The Strength of My Scars, written and illustrated by surgeon, Maria Baimas-George.

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Book SynopsisProviding a comprehensive introduction to stem cells with an emphasis on their role in craniofacial development, Stem Cells, Craniofacial Development and Regeneration details aspects of developmental biology with tissue engineering and regenerative medicine concepts.Table of ContentsContributors xi Preface xv PART I DEVELOPMENT AND REGENERATION OF CRANIOFACIAL TISSUES AND ORGANS 1 Molecular Blueprint for Craniofacial Morphogenesis and Development 3 Paul A. Trainor 2 Cranial Neural Crest Cells in Craniofacial Tissues and Organs 31 Carolina Parada and Yang Chai 3 Craniofacial Intramembranous Bone Development and Regeneration 51 David P. Rice and Ritva Rice 4 Temporomandibular Joint Development 71 Shuping Gu and YiPing Chen 5 Craniofacial Muscle Development 87 Robert G. Kelly 6 Tooth Morphogenesis and Renewal 109 Maria Jussila, Emma Juuri, and Irma Thesleff 7 Reptilian Tooth Regeneration 135 Joy M. Richman, John A. Whitlock, and John Abramyan 8 Tooth Root Development 153 Brian L. Foster, Francisco H. Nociti Jr., and Martha J. Somerman 9 Systems Biology of Early Tooth Development 179 Daniel J. O’Connell, Joshua W. K. Ho, and Richard L. Maas PART II STEM CELLS AND THEIR NICHES IN CRANIOFACIAL TISSUES 10 Stem Cells, Induced Pluripotent Stem Cells, and Their Differentiation to Specified Lineage Fates 205 George T.-J. Huang, Xiao-Ying Zou, Xing Yan, Kyle J. Hewitt, Yulia Shamis, and Jonathan A. Garlick 11 Bone Marrow Mesenchymal Stem Cells 223 Songtao Shi and Stan Gronthos 12 Adipose Tissue–Derived Stem Cells and Their Regeneration Potential 241 Jeffrey Gimble, Maryam Rezai Rad, and Shaomian Yao 13 Skeletal Muscle Stem Cells: Their Origin and Niche Factors 259 Johannes W. Von den Hoff and Sander Grefte 14 Stem Cells in Salivary Gland Development and Regeneration 271 Isabelle M. A. Lombaert and Matthew P. Hoffman 15 Stem and Progenitor Cells of Dental and Gingival Tissue Origin 285 Christian Morsczeck, George T.-J. Huang, and Songtao Shi 16 Regulation and Differentiation Potential of Dental Mesenchymal Stem Cells 303 Lei Wang, Christian Morsczeck, Stan Gronthos, and Songtao Shi 17 An Incisive Look at Stem Cells: The Mouse Incisor as an Emerging Model for Tooth Renewal 315 Frederic Michon, Andrew H. Jheon, Kerstin Seidel, and Ophir D. Klein 18 Mesenchymal Stem Cell Niches in Rodent Tooth Pulp 329 Jifan Feng and Paul T. Sharpe PART III STEM CELL–MEDIATED CRANIOFACIAL TISSUE BIOENGINEERING 19 Bone Bioengineering: Scaffolds, Growth Factors, and Stem Cells 341 Christopher S. D. Lee, Christopher D. Hermann, Rolando Gittens, Rene Olivares-Navarrete, Zvi Schwartz, and Barbara D. Boyan 20 Craniofacial Tissue Bioengineering and Regeneration by Endogenous Stem Cells 367 Nan Jiang, Mo Chen, Chang Hun Lee, Jian Zhou, Mildred C. Embree, Kimi Kong, Choko Cho, Avital Mendelson, Ying Zheng, Hemin Nie, and Jeremy J. Mao 21 Stem Cell–Based Bioengineering of Craniofacial Bone 379 David D. Lo, Daniel T. Montoro, Monica Grova, Jeong S. Hyun, Michael T. Chung, Derrick C. Wan, and Michael T. Longaker 22 Muscle Tissue Engineering Approaches 395 Johannes W. Von den Hoff and Sander Grefte 23 Engineering of Dental Tissues: Scaffolds and Preclinical Models 409 Na Yu, Adelina Plachokova, Fang Yang, X. Frank Walboomers, and John A. Jansen 24 Whole-Tooth Engineering and Cell Sources 431 L. Keller, S. Kuchler-Bopp, and Herv´e Lesot 25 Bioengineering of Functional Teeth 447 Takashi Tsuji 26 Pulp and Dentin Regeneration 461 Misako Nakashima and George T.-J. Huang 27 Bioengineering of Roots and Periodontal Tissues 485 Songlin Wang, Gang Ding, Fulan Wei, and Yi Liu 28 Periodontal Bioengineering Strategies: The Present Status and Some Developing Trends 501 Fa-Ming Chen and Yan Jin Index 525

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Book SynopsisA history of the little-known or forgotten academic origins of modern organ transplant surgery. This book investigates a crucial -- but forgotten -- episode in the history of medicine. In it, Thomas Schlich systematically documents and analyzes the earliest clinical and experimental organ transplant surgeries. In so doing helays open the historical origins of modern transplantation, offering a new and original analysis of its conceptual basis within a broader historical context. This first comprehensive account of the birth of modern transplantmedicine examines how doctors and scientists between 1880 and 1930 developed the technology and rationale for performing surgical organ replacement within the epistemological and social context of experimental university medicine. The clinical application of organ replacement, however, met with formidable obstacles even as the procedure became more widely recognized. Schlich highlights various attempts to overcome these obstacles, including immunologicalexplanations and new technologies of immune suppression, and documents the changes in surgical technique and research standards that led to the temporary abandonment of organ transplantation by the 1930s. Thomas Schlichis Professor and Canada Research Chair in the History of Medicine at McGill University.Trade ReviewSchlich highlights the fifty years preceding modern organ transplantation. This book. . . has historic interest referent to the biology discussed, demonstrating, for instance, that many ethical dilemmas are not the result of modern technology. . . This heavily annotated volume..should be a useful historical work for researchers generally. Recommended. * CHOICE *Table of ContentsAn ancient dream of mankind? What is special about organ transplantation? Before organ replacement: A natural history approach to disease The invention of organ transplantation Organotherapy and organ replacement Rise and decline of thyroid transplantation The discovery of a new organ: the parathyroid gland Laboratory and clinic: organ replacement for diabetes The many uses of the adrenal gland Reconstructing women: ovarian transplants Rejuvenating men: testicle transplants One principle, multiple applications: further organs From special case to prototype: the kidney Ethical problems with organ transplantation Laboratory and clinic: the epistemic and social context Methods of monitoring the success of transplants Disillusionment: The clinical failure of organ transplantation The strategy of technical perfection A new direction: transplant immunology Chance and necessity: a fresh start for organ transplantation

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