Description
Book SynopsisThis broad and accessible introduction to the study of blood has been fully revised and updated to reflect advances in the field and in clinical practice, covering essential knowledge, from basic hematological physiology to blood disorders and their diagnosis and treatment.
Trade Review“This book is an invaluable resource for medical students and health professionals wanting to consolidate and expand their knowledge of haematology.” (Kingbook73's Medical Ebook and Video Collection, 26 August 2014)
Table of ContentsPreface to the fourth edition 6
Preface to the first edition 6
Glossary 7
Normal values 8
About the companion website 9
Part 1 Basic physiology and practice
1 Haemopoiesis: physiology and pathology 10
2 Normal blood cells I: red cells 14
3 Normal blood cells II: granulocytes, monocytes and the reticuloendothelial system 18
4 Normal blood cells III: lymphocytes 20
5 Lymph nodes, the lymphatic system and the spleen 23
6 Clinical assessment 24
7 Laboratory assessment 26
Part 2 Red cell disorders
8 General aspects of anaemia 30
9 Iron I: physiology and deficiency 33
10 Iron II: overload and sideroblastic anaemia 36
11 Megaloblastic anaemia I: vitamin B 12 (B 12) and folate deficiency – biochemical basis, causes 38
12 Megaloblastic anaemia II: clinical features, treatment and other macrocytic anaemias 40
13 Haemolytic anaemias I: general 42
14 Haemolytic anaemias II: inherited membrane and enzyme defects 44
15 Haemolytic anaemias III: acquired 46
16 Haemolytic anaemias IV: genetic defects of haemoglobin – thalassaemia 48
17 Haemolytic anaemias V: genetic defects of haemoglobin – sickle cell disease 52
Part 3 Benign disorders of white cells
18 Benign disorders of white cells I: granulocytes, monocytes, macrophages 54
19 Benign disorders of white cells II: lymphocytes, lymph nodes, spleen, HIV 56
Part 4 Haematological malignancies
20 Introduction to Haematological malignancy: basic mechanisms 58
21 General aspects of treatment 61
22 Acute leukaemia I: classification and diagnosis 64
23 Acute leukaemia II: treatment and prognosis 68
24 Chronic Myeloid Leukaemia (BCR-ABL1 positive) 70
25 Myelodysplasia (myelodysplastic syndromes) 72
26 Myeloproliferative disorders I: introduction 74
27 Myeloproliferative disorders II: polycythaemia rubra vera 76
28 Myeloproliferative disorders III: essential thrombocythaemia, primary myelofibrosis and systemic mastocytosis 78
29 Chronic lymphocytic leukaemia 80
30 Multiple myeloma and plasma cell disorders 83
31 Lymphoma I: introduction 86
32 Lymphoma II: Hodgkin lymphoma 88
33 Lymphoma III: non-Hodgkin lymphoma – aetiology and classification 90
34 Lymphoma IV: clinical and laboratory features of more common subtypes 92
35 Lymphoma V: treatment and prognosis 94
Part 5 Treatment and procedures
36 Bone marrow failure 96
37 Haematological effects of drugs 98
38 Stem cell transplantation 100
Part 6 Haemostasis
39 Normal haemostasis I: vessel wall and platelets 102
40 Normal haemostasis II: coagulation factors and fibrinolysis 104
41 Disorders of haemostasis I: vessel wall and platelets 106
42 Disorders of haemostasis II: inherited disorders of coagulation 108
43 Disorders of haemostasis III: acquired disorders of coagulation 110
44 Thrombosis and anti-thrombotic therapy 112
45 Anticoagulation 115
Part 7 Haematological aspects of tropical disease
46 Haematological aspects of tropical diseases 118
47 Haematology of pregnancy and infancy 120
Part 8 Blood transfusion
48 Blood transfusion I 122
49 Blood transfusion II 124
Appendix: cluster of differentiation nomenclature system 127
Index 129
