Haematology Books

Book Synopsis* Integrated textbook combining three subjects, haematology, clinical biochemistry and immunology to provide a one-stop text on blood science, in line with the new IBMS and NHS training structure * Suitable for blood science courses opening in many universities at senior Undergraduate level (units) and Masters level.Table of ContentsPreface, xiii Acknowledgements, xv List of Abbreviations, xvii About the Companion Website, xxi 1 Introduction to Blood Science, 1 1.1 What is blood science?, 1 1.2 Biochemistry, 6 1.3 Blood transfusion, 8 1.4 Genetics, 10 1.5 Haematology, 14 1.6 Immunology, 17 1.7 The role of blood science in modern healthcare, 19 1.8 What this book will achieve, 22 Summary, 23 References, 23 Further reading, 23 Web sites, 23 2 Analytical Techniques in Blood Science, 25 2.1 Venepuncture, 25 2.2 Anticoagulants, 26 2.3 Sample identification and tracking, 27 2.4 Technical and analytical confidence, 27 2.5 Major techniques, 32 2.6 Molecular genetics, 43 2.7 Point of care testing, 47 2.8 Health and safety in the laboratory, 48 Summary, 49 Further reading, 50 Web sites, 50 3 The Physiology of the Red Blood Cell, 51 3.1 Introduction, 51 3.2 The development of blood cells, 52 3.3 Erythropoiesis, 56 3.4 The red cell membrane, 58 3.5 The cytoplasm of the red cell, 60 3.6 Oxygen transport, 66 3.7 Recycling the red cell, 68 3.8 Red cell indices in the full blood count, 69 3.9 Morphology of the red cell, 72 Summary, 74 Further reading, 74 4 The Pathology of the Red Blood Cell, 75 4.1 Introduction: diseases of red cells, 75 4.2 Anaemia resulting from attack on, or stress to, the bone marrow, 78 4.3 Anaemia due to deficiency, 80 4.4 Intrinsic defects in the red cell, 85 4.5 External factors acting on healthy cells, 100 4.6 Erythrocytosis and polycythaemia, 103 4.7 Molecular genetics and red cell disease, 105 4.8 Inclusion bodies, 105 4.9 Case studies, 105 Summary, 107 References, 107 Further reading, 107 5 White Blood Cells in Health and Disease, 109 5.1 Introduction, 109 5.2 Leukopoiesis, 111 5.3 Neutrophils, 115 5.4 Lymphocytes, 116 5.5 Monocytes, 117 5.6 Eosinophils, 118 5.7 Basophils, 119 5.8 Leukocytes in action, 120 5.9 White cells in clinical medicine, 127 5.10 Case studies, 132 Summary, 132 Further reading, 133 6 White Blood Cell Malignancy 135 6.1 The genetic basis of leukocyte malignancy, 135 6.2 Tissue techniques in haemato-oncology, 139 6.3 Leukaemia, 141 6.4 Lymphoma, 149 6.5 Myeloma and related conditions, 152 6.6 Myelofibrosis and myelodysplasia, 157 6.7 Case studies, 157 Summary, 158 Further reading, 159 Guidelines, 159 7 The Physiology and Pathology of Haemostasis, 161 7.1 The blood vessel wall, 162 7.2 Platelets, 163 7.3 The coagulation pathway, 165 7.4 Haemostasis as the balance between thrombus formation and removal, 168 7.5 The haemostasis laboratory, 171 7.6 The pathology of thrombosis, 173 Summary, 175 Further reading, 175 8 The Diagnosis and Management of Disorders of Haemostasis, 177 8.1 Thrombosis 1: overactive platelets and thrombocytosis, 177 8.2 Thrombosis 2: overactive coagulation, 181 8.3 Haemorrhage 1: platelet underactivity and thrombocytopenia, 193 8.4 Haemorrhage 2: coagulation underactivity, 199 8.5 Disseminated intravascular coagulation, 203 8.6 Molecular genetics in haemostasis, 204 8.7 Case studies, 205 Summary, 206 References, 206 Further reading, 207 Guidelines, 207 Web sites, 207 9 Immunopathology, 209 9.1 Introduction, 209 9.2 Basics of the immune system, 210 9.3 Humoral immunity, 212 9.4 Immunopathology 1: immunodeficiency, 215 9.5 Immunopathology 2: hypersensitivity, 221 9.6 Immunopathology 3: autoimmune disease, 226 9.7 Immunotherapy, 232 9.8 The immunology laboratory, 234 9.9 Case studies, 238 Summary, 239 References, 240 Further reading, 240 Guidelines, 240 Web sites, 240 10 Immunogenetics and Histocompatibility, 241 10.1 The genetics of antigen recognition, 241 10.2 Human leukocyte antigens, 245 10.3 Transplantation, 251 10.4 Autoimmunity and human leukocyte antigens, 257 Summary, 260 Further reading, 260 Guidelines, 260 Web sites, 260 11 Blood Transfusion, 261 11.1 Blood collection and processing, 262 11.2 Blood groups, 265 11.3 Laboratory practice of blood transfusion, 273 11.4 Clinical practice of blood transfusion, 279 11.5 Hazards of blood transfusion, 281 Summary, 284 References, 284 Further reading, 284 Guidelines, 284 Web sites, 285 12 Waste Products, Electrolytes and Renal Disease, 287 12.1 Renal anatomy and physiology, 287 12.2 Homeostasis, 288 12.3 Excretion, 295 12.4 Renal endocrinology, 297 12.5 Renal disease, 298 12.6 Case studies, 301 Summary, 303 Further reading, 303 Guidelines, 303 Web sites, 303 13 Hydrogen Ions, pH, and Acid–Base Disorders, 305 13.1 Ions and molecules, 305 13.2 Blood gases, 308 13.3 Acidosis (pH <7.3), 312 13.4 Alkalosis (pH >7.5), 313 13.5 Mixed acid–base conditions, 314 13.6 Clinical interpretation, 314 13.7 Case studies, 315 Summary, 316 Further reading, 317 Web site, 317 14 Glucose, Lipids and Atherosclerosis, 319 14.1 Glucose, 319 14.2 Dyslipidaemia, 333 14.3 Atherosclerosis, 343 14.4 Case studies, 347 Summary, 348 Further reading, 348 Guidelines, 349 Web sites, 349 15 Calcium, Phosphate, Magnesium and Bone Disease, 351 15.1 Calcium, 352 15.2 Phosphates, 355 15.3 Magnesium, 355 15.4 The laboratory, 355 15.5 Disorders of calcium homeostasis, 357 15.6 Disorders of phosphate homeostasis, 360 15.7 Disorders of magnesium homeostasis, 362 15.8 Bone physiology, 363 15.9 Bone disease, 364 15.10 Case studies, 368 Summary, 369 Further reading, 370 Guidelines, 370 Web sites, 370 16 Nutrients and Gastrointestinal Disorders, 371 16.1 Nutrients, 371 16.2 The intestines, 375 16.3 Case studies, 381 Summary, 382 Further reading, 382 Guidelines, 382 17 Liver Function Tests and Plasma Proteins, 383 17.1 Anatomy and physiology of the liver, 384 17.2 Liver function tests, 389 17.3 Diseases of the liver, 390 17.4 Plasma proteins, 396 17.5 Case studies, 405 Summary, 406 Further reading, 406 Web sites, 406 18 Hormones and Endocrine Disorders, 407 18.1 Endocrine physiology, 407 18.2 The pathology of the endocrine system, 417 18.3 Case studies, 434 Summary, 435 Further reading, 435 Web sites, 436 19 Cancer and Tumour Markers, 437 19.1 General concepts in cancer biology, 437 19.2 Blood science and cancer, 440 19.3 Molecular genetics, 444 19.4 Case studies, 445 Summary, 446 Further reading, 446 Guidelines, 447 Web sites, 447 20 Inherited Metabolic Disorders, 449 20.1 The genetics of inheritance, 449 20.2 Molecular inherited metabolic disorders, 451 20.3 Organelle inherited metabolic disorders, 455 20.4 Antenatal diagnosis and neonatal screening, 455 20.5 Case studies, 456 Summary, 457 Further reading, 457 21 Drugs and Poisons, 459 21.1 Toxicology, 459 21.2 Toxicology of specific compounds, 461 21.3 Therapeutic drug monitoring, 465 21.4 Case studies, 468 Summary, 469 References, 469 Further reading, 469 22 Case Reports in Blood Science, 471 Abbreviations, 471 Case report 1, 472 Anaemia, hypercalcaemia, proteinuria, myeloma Case report 2, 473 Diabetes, glycated haemoglobin, chronic renal failure Case report 3, 474 Acute kidney injury, leucocytosis, neutrophilia, viruses Case report 4, 475 Part 1: Obesity, colorectal cancer, CEA, hypothyroidism. Part 2: Alcoholism, raised GGT and triacylglycerols Case report 5, 477 Part 1: No abnormalities. Part 2: Asthma, raised IgE. Part 3: Falling haemoglobin, rising ESR, lung cancer Case report 6, 479 Hypothyroidism, marginally reduced haemoglobin Case report 7, 480 Raised CRP, ESR, rheumatoid factor and anti-nuclear antibodies; borderline anti-dsDNA antibodies, low C3, low eGFR and so mild renal failure, systemic lupus erythematosus Case report 8, 481 Normal blood results in renal transplantation Case report 9, 482 Falling albumin, eGFR, haemoglobin, red cell count and platelets, rising ESR, white cell count and neutrophila, CRP, urea and creatinine, septicaemia Case report 10, 484 Microcytic anaemia, thrombocytopenia, lymphocytosis, abnormal LFTs, falling albumin, raised CRP, myositis with raised CK, viruses Case report 11, 486 Acidosis, hyperglycaemia, diabetic ketoacidosis, acute renal injury, raised urea and creatinine Case report 12, 487 Low haemoglobin, thrombocytopenia, raised CRP and d-dimers, abnormal LFTs, malaria, pregnancy Case report 13, 488 Raised aldosterone, hypernatraemia, hypokalaemia, Conn’s syndrome Case report 14, 489 Paediatric diabetic ketoacidosis, hyperglycaemia, low bicarbonate, raised phosphates, ALP and proteins References, 490 Appendix: Reference Ranges, 491 Further Reading, 493 Glossary, 495 Index, 519

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Book Synopsis* Integrated textbook combining three subjects, haematology, clinical biochemistry and immunology to provide a one-stop text on blood science, in line with the new IBMS and NHS training structure * Suitable for blood science courses opening in many universities at senior Undergraduate level (units) and Masters level.Table of ContentsPreface, xiii Acknowledgements, xv List of Abbreviations, xvii About the Companion Website, xxi 1 Introduction to Blood Science, 1 1.1 What is blood science?, 1 1.2 Biochemistry, 6 1.3 Blood transfusion, 8 1.4 Genetics, 10 1.5 Haematology, 14 1.6 Immunology, 17 1.7 The role of blood science in modern healthcare, 19 1.8 What this book will achieve, 22 Summary, 23 References, 23 Further reading, 23 Web sites, 23 2 Analytical Techniques in Blood Science, 25 2.1 Venepuncture, 25 2.2 Anticoagulants, 26 2.3 Sample identification and tracking, 27 2.4 Technical and analytical confidence, 27 2.5 Major techniques, 32 2.6 Molecular genetics, 43 2.7 Point of care testing, 47 2.8 Health and safety in the laboratory, 48 Summary, 49 Further reading, 50 Web sites, 50 3 The Physiology of the Red Blood Cell, 51 3.1 Introduction, 51 3.2 The development of blood cells, 52 3.3 Erythropoiesis, 56 3.4 The red cell membrane, 58 3.5 The cytoplasm of the red cell, 60 3.6 Oxygen transport, 66 3.7 Recycling the red cell, 68 3.8 Red cell indices in the full blood count, 69 3.9 Morphology of the red cell, 72 Summary, 74 Further reading, 74 4 The Pathology of the Red Blood Cell, 75 4.1 Introduction: diseases of red cells, 75 4.2 Anaemia resulting from attack on, or stress to, the bone marrow, 78 4.3 Anaemia due to deficiency, 80 4.4 Intrinsic defects in the red cell, 85 4.5 External factors acting on healthy cells, 100 4.6 Erythrocytosis and polycythaemia, 103 4.7 Molecular genetics and red cell disease, 105 4.8 Inclusion bodies, 105 4.9 Case studies, 105 Summary, 107 References, 107 Further reading, 107 5 White Blood Cells in Health and Disease, 109 5.1 Introduction, 109 5.2 Leukopoiesis, 111 5.3 Neutrophils, 115 5.4 Lymphocytes, 116 5.5 Monocytes, 117 5.6 Eosinophils, 118 5.7 Basophils, 119 5.8 Leukocytes in action, 120 5.9 White cells in clinical medicine, 127 5.10 Case studies, 132 Summary, 132 Further reading, 133 6 White Blood Cell Malignancy 135 6.1 The genetic basis of leukocyte malignancy, 135 6.2 Tissue techniques in haemato-oncology, 139 6.3 Leukaemia, 141 6.4 Lymphoma, 149 6.5 Myeloma and related conditions, 152 6.6 Myelofibrosis and myelodysplasia, 157 6.7 Case studies, 157 Summary, 158 Further reading, 159 Guidelines, 159 7 The Physiology and Pathology of Haemostasis, 161 7.1 The blood vessel wall, 162 7.2 Platelets, 163 7.3 The coagulation pathway, 165 7.4 Haemostasis as the balance between thrombus formation and removal, 168 7.5 The haemostasis laboratory, 171 7.6 The pathology of thrombosis, 173 Summary, 175 Further reading, 175 8 The Diagnosis and Management of Disorders of Haemostasis, 177 8.1 Thrombosis 1: overactive platelets and thrombocytosis, 177 8.2 Thrombosis 2: overactive coagulation, 181 8.3 Haemorrhage 1: platelet underactivity and thrombocytopenia, 193 8.4 Haemorrhage 2: coagulation underactivity, 199 8.5 Disseminated intravascular coagulation, 203 8.6 Molecular genetics in haemostasis, 204 8.7 Case studies, 205 Summary, 206 References, 206 Further reading, 207 Guidelines, 207 Web sites, 207 9 Immunopathology, 209 9.1 Introduction, 209 9.2 Basics of the immune system, 210 9.3 Humoral immunity, 212 9.4 Immunopathology 1: immunodeficiency, 215 9.5 Immunopathology 2: hypersensitivity, 221 9.6 Immunopathology 3: autoimmune disease, 226 9.7 Immunotherapy, 232 9.8 The immunology laboratory, 234 9.9 Case studies, 238 Summary, 239 References, 240 Further reading, 240 Guidelines, 240 Web sites, 240 10 Immunogenetics and Histocompatibility, 241 10.1 The genetics of antigen recognition, 241 10.2 Human leukocyte antigens, 245 10.3 Transplantation, 251 10.4 Autoimmunity and human leukocyte antigens, 257 Summary, 260 Further reading, 260 Guidelines, 260 Web sites, 260 11 Blood Transfusion, 261 11.1 Blood collection and processing, 262 11.2 Blood groups, 265 11.3 Laboratory practice of blood transfusion, 273 11.4 Clinical practice of blood transfusion, 279 11.5 Hazards of blood transfusion, 281 Summary, 284 References, 284 Further reading, 284 Guidelines, 284 Web sites, 285 12 Waste Products, Electrolytes and Renal Disease, 287 12.1 Renal anatomy and physiology, 287 12.2 Homeostasis, 288 12.3 Excretion, 295 12.4 Renal endocrinology, 297 12.5 Renal disease, 298 12.6 Case studies, 301 Summary, 303 Further reading, 303 Guidelines, 303 Web sites, 303 13 Hydrogen Ions, pH, and Acid–Base Disorders, 305 13.1 Ions and molecules, 305 13.2 Blood gases, 308 13.3 Acidosis (pH <7.3), 312 13.4 Alkalosis (pH >7.5), 313 13.5 Mixed acid–base conditions, 314 13.6 Clinical interpretation, 314 13.7 Case studies, 315 Summary, 316 Further reading, 317 Web site, 317 14 Glucose, Lipids and Atherosclerosis, 319 14.1 Glucose, 319 14.2 Dyslipidaemia, 333 14.3 Atherosclerosis, 343 14.4 Case studies, 347 Summary, 348 Further reading, 348 Guidelines, 349 Web sites, 349 15 Calcium, Phosphate, Magnesium and Bone Disease, 351 15.1 Calcium, 352 15.2 Phosphates, 355 15.3 Magnesium, 355 15.4 The laboratory, 355 15.5 Disorders of calcium homeostasis, 357 15.6 Disorders of phosphate homeostasis, 360 15.7 Disorders of magnesium homeostasis, 362 15.8 Bone physiology, 363 15.9 Bone disease, 364 15.10 Case studies, 368 Summary, 369 Further reading, 370 Guidelines, 370 Web sites, 370 16 Nutrients and Gastrointestinal Disorders, 371 16.1 Nutrients, 371 16.2 The intestines, 375 16.3 Case studies, 381 Summary, 382 Further reading, 382 Guidelines, 382 17 Liver Function Tests and Plasma Proteins, 383 17.1 Anatomy and physiology of the liver, 384 17.2 Liver function tests, 389 17.3 Diseases of the liver, 390 17.4 Plasma proteins, 396 17.5 Case studies, 405 Summary, 406 Further reading, 406 Web sites, 406 18 Hormones and Endocrine Disorders, 407 18.1 Endocrine physiology, 407 18.2 The pathology of the endocrine system, 417 18.3 Case studies, 434 Summary, 435 Further reading, 435 Web sites, 436 19 Cancer and Tumour Markers, 437 19.1 General concepts in cancer biology, 437 19.2 Blood science and cancer, 440 19.3 Molecular genetics, 444 19.4 Case studies, 445 Summary, 446 Further reading, 446 Guidelines, 447 Web sites, 447 20 Inherited Metabolic Disorders, 449 20.1 The genetics of inheritance, 449 20.2 Molecular inherited metabolic disorders, 451 20.3 Organelle inherited metabolic disorders, 455 20.4 Antenatal diagnosis and neonatal screening, 455 20.5 Case studies, 456 Summary, 457 Further reading, 457 21 Drugs and Poisons, 459 21.1 Toxicology, 459 21.2 Toxicology of specific compounds, 461 21.3 Therapeutic drug monitoring, 465 21.4 Case studies, 468 Summary, 469 References, 469 Further reading, 469 22 Case Reports in Blood Science, 471 Abbreviations, 471 Case report 1, 472 Anaemia, hypercalcaemia, proteinuria, myeloma Case report 2, 473 Diabetes, glycated haemoglobin, chronic renal failure Case report 3, 474 Acute kidney injury, leucocytosis, neutrophilia, viruses Case report 4, 475 Part 1: Obesity, colorectal cancer, CEA, hypothyroidism. Part 2: Alcoholism, raised GGT and triacylglycerols Case report 5, 477 Part 1: No abnormalities. Part 2: Asthma, raised IgE. Part 3: Falling haemoglobin, rising ESR, lung cancer Case report 6, 479 Hypothyroidism, marginally reduced haemoglobin Case report 7, 480 Raised CRP, ESR, rheumatoid factor and anti-nuclear antibodies; borderline anti-dsDNA antibodies, low C3, low eGFR and so mild renal failure, systemic lupus erythematosus Case report 8, 481 Normal blood results in renal transplantation Case report 9, 482 Falling albumin, eGFR, haemoglobin, red cell count and platelets, rising ESR, white cell count and neutrophila, CRP, urea and creatinine, septicaemia Case report 10, 484 Microcytic anaemia, thrombocytopenia, lymphocytosis, abnormal LFTs, falling albumin, raised CRP, myositis with raised CK, viruses Case report 11, 486 Acidosis, hyperglycaemia, diabetic ketoacidosis, acute renal injury, raised urea and creatinine Case report 12, 487 Low haemoglobin, thrombocytopenia, raised CRP and d-dimers, abnormal LFTs, malaria, pregnancy Case report 13, 488 Raised aldosterone, hypernatraemia, hypokalaemia, Conn’s syndrome Case report 14, 489 Paediatric diabetic ketoacidosis, hyperglycaemia, low bicarbonate, raised phosphates, ALP and proteins References, 490 Appendix: Reference Ranges, 491 Further Reading, 493 Glossary, 495 Index, 519

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Book SynopsisTextbook of Hemophilia, 3rd edition Edited by Christine A. Lee, MA, MD, DSc, FRCP, FRCPath, FRCOG Emeritus Professor of Haemophilia, University of London, London, UK Erik E. Berntorp, MD, PhD Professor of Coagulation Medicine, Lund University Malmö Centre for Thrombosis and Haemostasis, Skåne University Hospital, Malmö, Sweden W. Keith Hoots, MD Director, Division of Blood Diseases and Resources, National Heart, Lung and Blood Institute National Institutes of Health, Bethesda, MD; Professor of Pediatrics and Internal Medicine, University of Texas Medical School at Houston, Houston, TX, USA Without doubt, Textbook of Hemophilia, 3rd edition is the definitive reference source on all aspects of haemophilia including diagnosis, management and treatment. Edited by three, world-renowned experts on haemophilia, this completely revised resource features chapters wriTable of ContentsContributors ix Historical introduction xv Christine A. Lee Part I: Introduction 1 Overview of hemostasis 3 Kathleen Brummel Ziedins and Kenneth G. Mann 2 Cellular processing of factor VIII and factor IX 9 Michael U. Callaghan and Randal J. Kaufman Part II: Hemophilia A 3 Molecular basis of hemophilia A 23 Geoffrey Kemball-Cook and Keith Gomez 4 Prophylaxis 33 Kathelijn Fischer and H. Marijke van den Berg Part III: Inhibitors to Factor VIII 5 Inhibitors to factor VIII: immunology 43 Jean-Marie R. Saint-Remy and Marc G. Jacquemin 6 Genetic and Environmental Risk Factors for Factor VIII inhibitor development 48 Jan Astermark 7 Epidemiology of inhibitors in hemophilia 53 Alfonso Iorio 8 Inhibitors to factor VIII: mild and moderate hemophilia 59 Kathelijne Peerlinck and Marc Jacquemin 9 Inhibitors to factor VIII/IX: immune tolerance 64 Donna M. DiMichele 10 Prophylaxis in inhibitor patients 72 Alessandro Gringeri 11 Inhibitors to factor VIII: treatment of acute bleeds 78 Claude Negrier Part IV: Acquired Hemophilia 12 Acquired inhibitors to factor VIII 87 Craig M. Kessler Part V: Hemophilia B 13 Hemophilia B: molecular basis 97 Keith Gomez and Pratima Chowdary 14 Factor IX inhibitors in hemophilia B 103 Meera B. Chitlur and Jeanne M. Lusher 15 Treatment of inhibitors in hemophilia B 107 Anand Tandra and Amy D. Shapiro Part VI: Pharmacokinetics of Factors VIII and IX 16 Pharmacokinetics 117 Sven Björkman 17 Individualized dosing 123 Peter W. Collins Part VII: Hemophilia: Birth to Old Age 18 Neonate with hemophilia 131 Angela E. Thomas and Elizabeth A. Chalmers 19 Work-up of a bleeding child 138 Manuel D. Carcao and Victor S. Blanchette 20 Care of the child with hemophilia 145 Rolf C.R. Ljung 21 Hemophilia in adolescence 150 Pia Petrini 22 Old age medicine and hemophilia 154 Evelien P. Mauser-Bunschoten and Roger E.G. Schutgens Part VIII: Products Used to Treat Hemophilia 23 Products used to treat hemophilia: recombinant products 165 Midori Shima and Akira Yoshioka 24 Products used to treat hemophilia: plasma-derived coagulation factor concentrates 174 Paul L.F. Giangrande 25 Products used to treat hemophilia: dosing 180 Miguel A. Escobar 26 Products used to treat hemophilia: regulation 185 Albert Farrugia 27 New drugs in the pipeline: from concept to clinic 192 Leonard A. Valentino Part IX: Surgical management 28 General surgical management of patients with hemophilia 199 Cindy Leissinger and Rebecca Kruse-Jarres 29 Continuous infusion of coagulation products in hemophilia 204 Angelika Batorova and Uri Martinowitz 30 Surgery in inhibitor patients 213 Pål Andrè Holme Part X: Musculoskeletal 31 Joint replacement in patients with hemophilia 221 Nicholas Goddard 32 Medical synovectomy (synoviorthesis) in hemophilia: radiosynovectomy and chemical synovectomy 228 E. Carlos Rodriguez-Merchan 33 Pseudotumors in patients with hemophilia 233 Michael Heim and Uri Martinowitz 34 Imaging modalities for assessment of hemophilic arthropathy 237 Andrea S. Doria and Björn Lundin 35 Physiotherapy in the management of hemophilia 247 Sébastien Lobet and David Stephensen 36 Outcome assessment in hemophilia 253 Pradeep M. Poonnoose and Alok Srivastava Part XI: Transfusion-transmitted Disease 37 Viral hepatitis and hemophilia 265 Michael Makris and Geoffrey Dusheiko 38 Transfusion-transmitted disease: emerging infections 272 Thomas R. Kreil 39 vCJD and hemophilia 277 Carolyn M. Millar Part XII: Gene Therapy 40 Hemophilia gene therapy: an overview 285 David Lillicrap 41 Gene therapy trials in hemophilia A and B 291 Katherine A. High 42 Gene therapy: molecular engineering of factor VIII and factor IX 298 Sundar R. Selvaraj and Steven W. Pipe Part XIII: Laboratory 43 Laboratory and quality control of assays 311 Steve Kitchen 44 Standardization of assays in hemophilia 318 Sanj Raut and Trevor W. Barrowcliffe 45 Global laboratory assays in hemophilia 328 Benny Sørensen and Guy Young Part XIV: Women and Bleeding Disorders 46 Obstetrics and gynecology: hemophilia 337 Rezan A. Kadir and Christine A. Lee 47 Women and von Willebrand disease 345 Peter A. Kouides Part XV: von Willebrand Disease 48 von Willebrand disease: molecular aspects 355 Daniel Hampshire and Anne Goodeve 49 von Willebrand disease: epidemiology 362 Francesco Rodeghiero and Giancarlo Castaman 50 von Willebrand disease: biological diagnosis 370 Veronica H. Flood and Robert R. Montgomery 51 Classification and clinical aspects of von Willebrand disease 377 Augusto B. Federici 52 Treatment of von Willebrand disease: desmopressin 386 Pier M. Mannucci 53 Treatment of von Willebrand disease: therapeutic concentrates 390 Erik E. Berntorp Part XVI: Rare Bleeding Disorders 54 Factor II 399 Jan Astermark 55 Factor V and combined factor V and VIII deficiencies 403 Flora Peyvandi and Marzia Menegatti 56 Congenital factor VII deficiency 413 Angelika Batorova 57 Factor X and factor X deficiency 421 David J. Perry 58 Factor XI deficiency 428 Paula H.B. Bolton-Maggs and Uri Seligsohn 59 Factor XIII deficiency 436 Diane Nugent and Loan Hsieh 60 Fibrinogen deficiency 445 Michael Laffan 61 Miscellaneous rare bleeding disorders 452 Frederico Xavier and Amy D. Shapiro Part XVII: Emergency Medicine 62 Emergency management of hemophilia 463 W. Keith Hoots Part XVIII: Evaluation of Hemophilia 63 Clinical trials and other methodologies 473 Sharyne M. Donfield and Alice E. Lail 64 Quality of life in hemophilia 478 Sylvia von Mackensen and Alessandro Gringeri 65 The economics of hemophilia treatment 489 Katarina Steen Carlsson and Erik E. Berntorp Part XIX: Comprehensive Care and Delivery of Care 66 Hemophilia databases 497 Charles R.M. Hay 67 Comprehensive care and delivery of care: the developed world 502 Christopher A. Ludlam and Cedric R.J.R. Hermans 68 Comprehensive care and delivery of care in hemophilia: the developing world 508 Alok Srivastava and Auro Viswabandya 69 Comprehensive care and delivery of care: the global perspective 515 Mark W. Skinner and Alison M. Street Index 523 Color plate section can be found facing page 202

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Book SynopsisA clinical guide to transplantation in lymphoma to present advanced knowledge on how to integrate, transplantat and other novel therapies in patients with lymphoid malignancies. It provides practical management guidance on how to integrate, transplant and other novel therapies in patients with lymphoid malignancies.Trade ReviewSir William Osler is reputed to have said, “Listen to the patient and he will give you the answer.” Had he been alive now and practicing transplantation for lymphoma, he could have well said “Read the Clinical Guide to Transplantation in Lymphoma and it will give you the answer.” These reviewers are very impressed by the breadth and scope of this book edited by Drs. Bipin Savani and Mohamed Mohty, ably aided by an array of expert contributors from all over the world.Clinical Guide to Transplantation in Lymphoma is extremely easy to read and very well written. In this era ofexponential information growth this book is surprisingly current, with the latest references. It has an ambitious scope, setting out to cover all aspects of transplantation in lymphoma and managing to meet that expectation.Chapters are laid out in logical sequence divided into 2 sections. Section 1 is particularly interesting and haschapters on the historical perspective of transplantation for lymphoma, transplant data collection and reporting, and analytical methods. The remainder of section 1 describes the general principles of transplantation in lymphomas, addressing issues such as mobilization, preparative regimens, and management of the early, late, and long-term issues arising after transplantation. Some chapters include transplantation for lymphoma in children, adults, and young adolescents; pretransplant evaluation; preparative regimens for autologous and allogeneic transplants; stem cell mobilization and stem cell source; post-transplant follow-up for autologousand allogeneic transplant, and a novel chapter, “First 100 Days of the Autologous Hematopoietic Stem Cell Transplantation Process in Lymphoma.” The chapters in section 1 are broadly applicable and would prove invaluable to trainees pursuing fellowships in hematopoietic cell transplantation.Section 2 is laid out as a chapter by chapter discussion of various lymphoma histologies and the applicability of hematopoietic cell transplantation in each. One can return to some of these chapters again and again because all common and most rare lymphoma subtypes (including HIV-associated lymphoma) are discussed in excellent detail. We found each one of these chapters to be remarkably up to date. In a field such ashematopoietic cell transplantation,where there is considerable ambiguity and few randomized studies, the authors and editors have maintained a neutral and unbiased tone,discussing the available data andguidelines exhaustively.Very few similar textbooks focus on transplantation in a disease group. Clinical Guide to Transplantation in Lymphoma is concise enough, practical, and clinically oriented to be considered a practical manual but at the same time manages to be comprehensive. Some unique features in this book are the numerous excellent graphs and tables and the discussion of case studies and clinical guidelines (United States and European) wherever applicable. We found very few typographic errors. For future editions we recommend at least 1 chapter devoted to the emerging field of cellular immunotherapy.The editors and the contributors need to be congratulated for an encyclopedic work that still manages to be a ready reference guide. This book will be used extensively and should be in the library of every transplanter.We hope it runs into many future editions and becomes the authoritative textbook for transplantation in lymphoma. (Yogesh Jethava, Parameswaran Hari, University of Arkansas for Medical Science, Biology of Blood and Marrow Transplantation, Nov 2015)Table of ContentsList of contributors vii Foreword xi Introduction 1 Section 1: Transplantation in lymphomas 1 Lymphoma and transplantation: historical perspective 5Andrew R. Rezvani 2 Lymphoma: working committee and data reporting after transplantation in lymphoma 13Wael Saber, Mehdi Hamadani, Shahrukh Hashmi and Parameswaran Hari 3 Use of transplantation in lymphoma: adults 23Parastoo Bahrami Dahi, Gabriela Soriano Hobbs and Miguel]Angel Perales 4 Hematopoietic stem cell transplantation for lymphoma in children, adolescents, and young adults 31Nader Kim El]Mallawany and Mitchell S. Cairo 5 Preparative regimens for lymphoma: autologous hematopoietic stem cell transplantation 45Taiga Nishihori, Karma Z. Salem, Ernesto Ayala and Mohamed A. Kharfan]Dabaja 6 Preparative regimens for lymphoma: allogeneic hematopoietic stem cell transplantation 57Mohamed A. Kharfan]Dabaja, Najla El]Jurdi, Mehdi Hamadani and Ernesto Ayala 7 Pretransplantation evaluation, comorbidities, and nondisease]related eligibility criteria for transplantation in lymphoma, 69Melissa Logue 8 Stem cell mobilization in lymphoma patients 75Tarah Ballinger, Bipin N. Savani and Mohamad Mohty 9 Allogeneic hematopoietic stem cell transplantation for lymphoma: stem cell source, donor, and HLA matching 85Michael Green and Mitchell Horwitz 10 Management of early and late toxicities of autologous hematopoietic stem cell transplantation 93Sai Ravi Pingali and Yago Nieto 11 Long]term follow]up of lymphoma patients after allogeneic hematopoietic cell transplantation 103Shylaja Mani and Navneet S. Majhail 12 First 100 days of the autologous hematopoietic stem cell transplantation process in lymphoma 109Angela Moreschi Woods 13 First 100 days of the allogeneic hematopoietic stem cell transplantation process in lymphoma 113Angela Moreschi Woods Section 2: Management 14 Stem cell transplantation in follicular lymphoma,119Satyajit Kosuri and Koen Van Besien 15 Chronic lymphocytic leukemia/small lymphocytic lymphoma 133Salyka Sengsayadeth and Wichai Chinratanalab 16 Diffuse large B]cell lymphoma 145Lauren Veltri, Bipin N. Savani, Mohamed A. Kharfan]Dabaja, Mehdi Hamadani and Abraham S. Kanate 17 Mantle cell lymphoma 161Sascha Dietrich and Peter Dreger 18 Hodgkin lymphoma 173Eva Domingo]Domenech and Anna Sureda 19 Peripheral T]cell lymphomas 187Giulia Perrone, Chiara De Philippis, Lucia Farina and Paolo Corradini 20 Transplantation in Burkitt and lymphoblastic lymphoma 201Gregory A. Hale 21 Transplantation in adult T]cell leukemia/lymphoma 209Ali Bazarbachi and Olivier Hermine 22 Hematopoietic cell transplantation for HIV]related lymphomas 217Joseph C. Alvarnas 23 Stem cell transplantation for mycosis fungoides/Sézary syndrome 233Eric D. Jacobsen 24 Role of transplantation in lymphoplasmacytic lymphoma 241Silvia Montoto and Charalampia Kyriakou 25 Transplantation outcome in primary mediastinal large B]cell lymphoma 247Amanda F. Cashen 26 Management of post]transplant lymphoproliferative disorders 253Jan Styczynski and Per Ljungman Appendix I Follow]up calendar after autologous stem cell transplantation in lymphoma 261Angela Moreschi Woods Appendix II Follow]up calendar after allogeneic stem cell transplantation in lymphoma 263Angela Moreschi Woods Index 265

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Book SynopsisProviding the practicing and trainee hematologist with a practical and immediately applicable compendium of answers the Clinical Manual of Blood and Bone Marrow Transplantation covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program. Supplies the practicing and trainee hematologist with a practical and immediately applicable compendium of answers to clinical questionsCovers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant programContains concise chapters written with a focus on tables, algorithms and figures to aid rapid referralBenefits from expert contributions from an international authorshipTrade Review"... the book provides a concise practical expert review in a well-organized format of 42 chapters, each annotated with numerous practical headings to enhance focused learning. The expert authors of each chapter in the Clinical Manual of Blood and Bone Marrow Transplantation are part of that success story, and their up-to-date contributions to the field are elucidated in the clearest of terms in this worthy addition to the literature. This book is recommended for The ASCO Post readers, especially residents and fellows who are interested in pursuing a career in blood cancers" (The ASCO Post, September 2017)Table of ContentsContributors, ix Preface, xiv 1 Donor and graft selection strategy, 1Ayman Saad, Marisa B. Marques, and Shin Mineishi 2 HLA typing and implications, 9Bronwen E. Shaw and Stephen R. Spellman 3 Risk]benefit assessment in allogeneic hematopoietic transplant: Factors, scores, and models, 19Mahmoud Elsawy and Mohamed L. Sorror 4 Donor and recipient pre]transplant evaluation, 36Shuang Fu and Navneet S. Majhail 5 Autologous and allogeneic progenitor cell mobilization, 45Racquel D. Innis]Shelton and Luciano J. Costa 6 Hematopoietic stem and progenitor cell collection by apheresis: Techniques and tricks, 53Anand Padmanabhan 7 Hematopoietic cell processing: From procurement to infusion, 59Jay S. Raval, Kathryn McKay, and Yara A. Park 8 Graft manipulation: T-cell depletion and beyond, 66Christina Cho and Miguel]Angel Perales 9 Graft]versus]host disease prophylaxis, 73Melhem Solh and Asad Bashey 10 Acute lymphoblastic leukemia, 80Ghada Zakout and Adele K. Fielding 11 Acute myeloid leukemia, 89Hillard M. Lazarus and Masumi Ueda 12 Myelodysplastic syndromes, 97Melinda Biernacki and H. Joachim Deeg 13 Chronic myelogenous leukemia, 108Daniel Egan and Jerald Radich 14 Philadelphia chromosome negative myeloproliferative neoplasms, 116Nicolaus Kröger 15 Chronic lymphocytic leukemia, 123Fabienne McClanahan Lucas and John Gribben 16 Hodgkin Lymphoma, 131Anna Sureda and Eva Domingo]Domenech 17 Indolent lymphomas, 140Narendranath Epperla, Hamza Hashmi, and Mehdi Hamadani 18 Diffuse large B-cell lymphoma, 151Syed Abbas Ali, Istvan Redei, and Syed A. Abutalib 19 Mantle cell lymphoma, 164Narendranath Epperla and Timothy S. Fenske 20 T-cell lymphoma, 179Adrienne A. Phillips and Koen van Besien 21 Primary CNS lymphoma, 188Henry C. Fung, Philip Pancari, and Patricia Kropf 22 Autologous hematopoietic transplant in multiple myeloma, 194Nisha S. Joseph, Ajay K. Nooka, and Sagar Lonial 23 Allogeneic hematopoietic transplant in multiple myeloma, 207Parameswaran Hari and Binod Dhakal 24 Light]chain amyloidosis, 214Amara S. Hussain and Anita D’Souza 25 Autoimmune disorders, 221Adam Bryant and Harold Atkins 26 Testicular cancer, 229Moshe C. Ornstein, Navneet S. Majhail, and Timothy Gilligan 27 Sickle cell disease, 236Sonali Chaudhury and Shalini Shenoy 28 Hematopoietic cell transplant in thalassemia, 246Emanuele Angelucci and Federica Pilo 29 Fanconi anemia, 255Flore Sicre de Fontbrune, Jean Soulier, and Regis Peffault de Latour 30 Immunodeficiency disorders, 264Jennifer A. Kanakry and Dennis D. Hickstein 31 Inherited metabolic disorders, 272Jaap Jan Boelens and Robert F. Wynn 32 Aplastic anemia and paroxysmal nocturnal hemoglobinuria, 281Andrew C. Dietz and Michael A. Pulsipher 33 HIV infection and transplantation, 290Nitya Nathwani, Stephen J. Forman, and Amrita Krishnan 34 Engraftment and graft failure: Assessment and practical considerations, 297Yogesh Jethava, Madan Jagasia, Mohamed Mohty, and Bipin N. Savani 35 Immune reconstitution and tolerance, 304udovic Belle and William R. Drobyski 36 Donor lymphocyte infusion, 315David C. Halverson and Daniel Fowler 37 Diagnosis and treatment of acute graft]versus]host disease, 324Natasha Kekre and Vincent T. Ho 38 Diagnosis and treatment of chronic graft]versus]host disease, 334Sabarinath Venniyil Radhakrishnan and Daniel R. Couriel 39 Prevention and treatment of infection, 348Corrado Girmenia, Gian Maria Rossolini, and Claudio Viscoli 40 Early non]infectious complications after hematopoietic cell transplantation, 359Piyanuch Kongtim and Stefan O. Ciurea 41 Post]transplant lymphoproliferative disorders, 369Michael D. Keller, Conrad R. Cruz, and Catherine M. Bollard 42 Survivorship issues after transplantation, 376Vanessa E. Kennedy, Madan Jagasia, and Bipin N. Savani Index, 384

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Book SynopsisTable of ContentsPreface vii Part 1 Introduction 1 1 Introduction to endocrinology 2 Part 2 Disorders of the hypothalamic–pituitary axis 5 2 The hypothalamic–pituitary axis and its assessment 6 3 Acromegaly 8 4 Cushing’s syndrome 10 5 Hypopituitarism and non-functioning pituitary adenomas 12 6 Prolactinoma and hyperprolactinaemia 14 Part 3 Disorders of thirst and fluid balance 17 7 Hypernatraemia and diabetes insipidus 18 8 Hyponatraemia and SIADH 20 Part 4 Thyroid disorders 23 9 Thyroid function 24 10 Hyperthyroidism: clinical presentation and investigation 26 11 Hyperthyroidism: management and ophthalmopathy 28 12 Hyperthyroidism: special circumstances 30 13 Hypothyroidism 32 14 Goitre, thyroid nodules and cancer 34 Part 5 Disorders of calcium homeostasis 37 15 Physiology of calcium, PTH and vitamin D metabolism 38 16 Hypercalcaemia 40 17 Hypocalcaemia 42 18 Osteoporosis 44 Part 6 Disorders of the adrenal gland 47 19 Steroid physiology and biochemical assessment 48 20 Adrenal insufficiency 50 21 Adrenocortical tumours 52 22 Disorders of the adrenal medulla 54 Part 7 Disorders of the reproductive system 57 23 Physiology of the reproductive system 58 24 Growth, puberty and sexual differentiation 60 25 Menstrual disturbance 62 26 Hyperandrogenism 64 27 Menopause and HRT 66 28 Male hypogonadism 68 29 Gynaecomastia 70 30 Infertility 72 Part 8 Neuroendocrine tumours 75 31 Neuroendocrine tumours 76 32 Neuroendocrine tumours: management 78 33 Inherited endocrine tumour syndromes 80 34 Spontaneous hypoglycaemia 82 Part 9 Endocrine emergencies 85 35 Adrenal crisis 86 36 Pituitary apoplexy 88 37 Myxoedema coma 90 38 Thyroid storm 92 39 Acute hyponatraemia 94 40 Severe hypercalcaemia 96 41 Acute hypocalcaemia 98 Part 10 Diabetes mellitus 101 42 Overview 102 43 Diagnosis and monitoring 104 44 Classification 106 45 Type 1 diabetes: aetiology and clinical presentation 108 46 Type 1 diabetes: insulin and other therapies 110 47 Type 2 diabetes: aetiology and clinical presentation 112 48 Type 2 diabetes: treatment 114 49 Macrovascular complications 116 50 Microvascular complications 118 51 Diabetic foot disease 120 52 Diabetic ketoacidosis 122 53 Hyperglycaemic hyperosmolar state 124 54 Hypoglycaemia 126 55 Peri-operative management 128 56 Management of acute illness 131 57 Insulin infusions 134 58 Pregnancy and diabetes 136 59 Genetics of diabetes 138 60 The multidisciplinary team 140 61 Lipid disorders 142 62 Appetite and weight 144 63 Obesity and anorexia 146 Index 148

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Book SynopsisThe third edition of this popular pocket book, A Beginner's Guide to Blood Cells written by Professor Barbara Bain, provides a concise introduction to normal and abnormal blood cells and blood counts for trainees in haematology. Includes a brand new chapter on emergency morphology, designed to make the clinical significance and urgency of certain laboratory findings clear for biomedical scientists and to assist trainee haematologists in the recognition of major clinically important abnormalities Contains exceptional full colour images throughout Introduces important basic concepts of hematology, setting haematological findings in a clinical context Provides a fully updated self-assessment section An essential resource for trainee haematologists, biomedical scientists, and biomedical science and medical students Table of ContentsPreface vii Abbreviations viii 1 The Blood Film and Count 1 Blood 1 The blood film 1 The blood count 17 Normal ranges 20 How to examine a blood film 22 2 Assessing Red Cells 29 Assessing red cell number and distribution (anaemia polycythaemia rouleaux formation red cell agglutination) 29 Assessing red cell size (microcytosis macrocytosis anisocytosis) 32 Assessing red cell shape (poikilocytosis) 32 Assessing red cell colour (hypochromia hyperchromia anisochromasia polychromasia) 32 Detecting red cell inclusions (Pappenheimer bodies basophilic stippling Howell–Jolly bodies) 41 The full blood count in red cell assessment 43 3 Assessing White Cells and Platelets 45 Assessing white cell and platelet numbers 45 Assessing neutrophil morphology 46 Assessing lymphocyte morphology 51 Assessing morphology of monocytes eosinophils and basophils 53 Assessing platelet morphology 53 4 Haematological Findings in Health and Disease 55 The blood film and count in healthy individuals 55 Abnormalities of red cells 56 Abnormalities of white cells 77 5 Emergency Morphology: The Relevance of the Full Blood Count and Blood Film in Acute Illness 97 Thrombocytopenia 97 Thrombotic microangiopathy and microangiopathic haemolytic anaemia 98 Other acute anaemia 100 Kidney injury and disease 105 Acute hepatic damage and liver failure 107 Acute leukaemia 109 Bacterial infection and other causes of leucocytosis 109 Eosinophilia 113 Lymphocytosis 115 Malaria 116 Neutropenia 119 Pancytopenia and leucoerythroblastic blood films 121 Neonatal emergencies 122 6 Self]assessment 125 Index 143

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Book SynopsisTable of ContentsPreface vii About the companion website ix 1 An introduction to haematopoiesis 1 2 The blood count in health and disease 15 3 Anaemia: general principles 23 4 Haemolytic anaemias 39 5 Disorders of globin synthesis 55 6 An introduction to haematological malignancies 71 7 Cellular and molecular investigations in haematology 79 8 Neoplastic disorders of myeloid cells 91 9 Neoplastic disorders of lymphoid cells 105 10 Plasma cell myeloma and other paraproteinaemias 121 11 Aplastic anaemia and pure red cell aplasia 131 12 Stem cell transplantation and cellular therapy 137 13 Haemostasis and bleeding disorders 147 14 Thrombosis and anticoagulant therapy 163 15 Blood groups and blood transfusion 173 Index 187

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Book SynopsisABC of Clinical Haematology An essential guide and introduction to the diagnosis, treatment and management of disorders across the breadth of clinical haematology Extensively revised, this 5th edition of ABC of Clinical Haematology covers all aspects of contemporary haematology, providing the basic science behind the disease and diagnostic aspects, along with up to date management. The text assumes little prior haematology knowledge, enabling clear understanding by non-experts, including medical students and nurses. Full colour illustrations and text boxes highlighting important learning points together enable more efficient reader comprehension. ABC of Clinical Haematology covers: Iron deficiency anaemia, macrocytic anaemia, hereditary anaemias, polycythaemia vera, essential thrombocythaemia, and myelofibrosis Chronic myeloid leukaemia, acute leukaemias, lymphoma, stem cell transplantation, cellular therapies, adult myelodysplastic syndrome, and myeloma Bleeding disorders, thrombosis, anticoagulation, and paediatric haematology, platelet disorders Amyloidosis, with focus on systemic light chain amyloidosis, and haematological emergencies New tests, treatments, and management solutions that are now available for certain conditions, especially common blood related disorders With contributions from leading experts in their respective fields, ABC of Clinical Haematology, Fifth Edition provides an ideal reference for primary care practitioners and other healthcare professionals working with patients who have blood related problems. About the ABC series The ABC series has been designed to help you access information quickly and deliver the best patient care, and remains an essential reference tool for GPs, junior doctors, medical students and healthcare professionals. Now offering over 80 titles, this extensive series provides you with a quick and dependable reference on a range of topics in all the major specialties. The ABC series is the essential and dependable source of up-to-date information for all practitioners and students in primary healthcare. To receive automatic updates on books and journals in your specialty, join our email list. Sign up today at www.wiley.com/emailTable of ContentsContributors iv Preface to the Fifth Edition v 1 Iron Deficiency Anaemia 1 Catherine Booth and Drew Provan 2 Macrocytic Anaemia 7 Samah Babiker and Nita Prasannan 3 The Hereditary Anaemias 13 Rachel Kesse- Adu 4 Polycythaemia Vera Essential Thrombocythaemia and Myelofibrosis 19 Anna L. Godfrey and Claire Harrison 5 Chronic Myeloid Leukaemia 25 Hugues de Lavallade 6 The Acute Leukaemias 31 Michael Austin and Bela Patel 7 Platelet Disorders 39 Marie A. Scully and John Paul Westwood 8 Adult Myelodysplastic Syndrome 47 Sally B. Killick 9 Myeloma and Other Plasma Cell Dyscrasias 53 Sally Moore and Karthik Ramasamy 10 Bleeding Disorders Thrombosis and Anticoagulation 59 Vickie McDonald 11 Lymphoma 65 Karen Stanley and David Wrench 12 Stem Cell Transplantation 81 Michelle Escebedo- Cousin and Kirsty Thomson 13 Cellular Therapies 87 Reuben Benjamin 14 Paediatric Haematology 91 John D. Grainger and Lianna Reynolds 15 Amyloidosis with a Focus on Systemic Light Chain Amyloidosis 101 Ayesha Shameem Mahmood 16 Haematological Emergencies 109 Vered Stavi and Igor Novitzky- Basso Index 119

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Book SynopsisThis broad and accessible introduction to the study of blood has been fully revised and updated to reflect advances in the field and in clinical practice, covering essential knowledge, from basic hematological physiology to blood disorders and their diagnosis and treatment.Trade Review“This book is an invaluable resource for medical students and health professionals wanting to consolidate and expand their knowledge of haematology.” (Kingbook73's Medical Ebook and Video Collection, 26 August 2014)Table of ContentsPreface to the fourth edition 6 Preface to the first edition 6 Glossary 7 Normal values 8 About the companion website 9 Part 1 Basic physiology and practice 1 Haemopoiesis: physiology and pathology 10 2 Normal blood cells I: red cells 14 3 Normal blood cells II: granulocytes, monocytes and the reticuloendothelial system 18 4 Normal blood cells III: lymphocytes 20 5 Lymph nodes, the lymphatic system and the spleen 23 6 Clinical assessment 24 7 Laboratory assessment 26 Part 2 Red cell disorders 8 General aspects of anaemia 30 9 Iron I: physiology and deficiency 33 10 Iron II: overload and sideroblastic anaemia 36 11 Megaloblastic anaemia I: vitamin B 12 (B 12) and folate deficiency – biochemical basis, causes 38 12 Megaloblastic anaemia II: clinical features, treatment and other macrocytic anaemias 40 13 Haemolytic anaemias I: general 42 14 Haemolytic anaemias II: inherited membrane and enzyme defects 44 15 Haemolytic anaemias III: acquired 46 16 Haemolytic anaemias IV: genetic defects of haemoglobin – thalassaemia 48 17 Haemolytic anaemias V: genetic defects of haemoglobin – sickle cell disease 52 Part 3 Benign disorders of white cells 18 Benign disorders of white cells I: granulocytes, monocytes, macrophages 54 19 Benign disorders of white cells II: lymphocytes, lymph nodes, spleen, HIV 56 Part 4 Haematological malignancies 20 Introduction to Haematological malignancy: basic mechanisms 58 21 General aspects of treatment 61 22 Acute leukaemia I: classification and diagnosis 64 23 Acute leukaemia II: treatment and prognosis 68 24 Chronic Myeloid Leukaemia (BCR-ABL1 positive) 70 25 Myelodysplasia (myelodysplastic syndromes) 72 26 Myeloproliferative disorders I: introduction 74 27 Myeloproliferative disorders II: polycythaemia rubra vera 76 28 Myeloproliferative disorders III: essential thrombocythaemia, primary myelofibrosis and systemic mastocytosis 78 29 Chronic lymphocytic leukaemia 80 30 Multiple myeloma and plasma cell disorders 83 31 Lymphoma I: introduction 86 32 Lymphoma II: Hodgkin lymphoma 88 33 Lymphoma III: non-Hodgkin lymphoma – aetiology and classification 90 34 Lymphoma IV: clinical and laboratory features of more common subtypes 92 35 Lymphoma V: treatment and prognosis 94 Part 5 Treatment and procedures 36 Bone marrow failure 96 37 Haematological effects of drugs 98 38 Stem cell transplantation 100 Part 6 Haemostasis 39 Normal haemostasis I: vessel wall and platelets 102 40 Normal haemostasis II: coagulation factors and fibrinolysis 104 41 Disorders of haemostasis I: vessel wall and platelets 106 42 Disorders of haemostasis II: inherited disorders of coagulation 108 43 Disorders of haemostasis III: acquired disorders of coagulation 110 44 Thrombosis and anti-thrombotic therapy 112 45 Anticoagulation 115 Part 7 Haematological aspects of tropical disease 46 Haematological aspects of tropical diseases 118 47 Haematology of pregnancy and infancy 120 Part 8 Blood transfusion 48 Blood transfusion I 122 49 Blood transfusion II 124 Appendix: cluster of differentiation nomenclature system 127 Index 129

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Book SynopsisPublisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.Hemostasis and Thrombosis as only Williams can cover itIN FULL COLOR!A Doodyâs Core Title for 2019! Featuring twenty-five clinically relevant chapters originally appearing in Williams Hematology, Ninth Edition â many carefully updated by the original authors to reflect the latest developments -- this concise, full-color resource delivers comprehensive and up-to-date coverage of hemostasis and thrombosis. The result of this unique compilation is a focused, timely resource that will be of particular value to advanced medical students who seeks a more detailed review of hematology than generally presented in second year medical school, medicine and pediatric resideTable of ContentsTable of ContentsChapter 1. Megakaryopoiesis and ThrombosisChapter 2. Platelet Morphology, Biochemistry, and FunctionChapter 3. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of HemostasisChapter 4. Control of Coagulation ReactionsChapter 5. Vascular Function in HemostasisChapter 6. Classification, Clinical Manifestations and Evaluation of Disorders of Hemostasis Chapter 7. ThrombocytopeniaChapter 8. Heparin-Induced ThrombocytopeniaChapter 9. Reactive ThrombocytosisChapter 10. Hereditary Qualitative Platelet DisordersChapter 11. Acquired Qualitative Platelet DisordersChapter 12. The Vascular PurpurasChapter 13. Hemophilia A and Hemophilia BChapter 14. Inherited Deficiencies of Coagulation Factors II, V, V+VIII, VII, X, XI, and XIIIChapter 15. Hereditary Fibrinogen AbnormalitiesChapter 16. von Willebrand DiseaseChapter 17. Antibody-Mediated Coagulation Factor DeficienciesChapter 18. Hemostatic Alterations in Liver Disease and Liver TransplantationChapter 19. Disseminated Intravascular CoagulationChapter 20. Hereditary ThrombophiliaChapter 21. The Antiphospholipid SyndromeChapter 22. Thrombotic MicroangiopathiesChapter 23. Venous ThrombosisChapter 24. Atherothrombosis: Disease Initiation, Progression, and TreatmentChapter 25. Fibrinolysis and Thrombolysis

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Book SynopsisA comprehensive series of multiple-choice questions and answers to help readers strengthen their knowledge of hematopathology and coagulation to prepare for their American Board of Pathology exams. All areas of the curriculum, from red blood cell count and coagulation disorders to hematopoietic neoplasms, are covered, and explanations are given to aid learning.Table of ContentsPreface; Part I. Non Neoplastic Hematology: 1. RBC disorders; Answers to chapter 1; Answers to chapter 1 (with explanations); 2. Non neoplastic WBC and platelet disorders; Answers to chapter 2; Answers to chapter 2 (with explanations); 3. Benign lymph node; Answers to chapter 3; Answers to chapter 3 (with explanations); Part II. Hematopoietic Neoplasms: 4. Myeloid neoplasms; Answers to chapter 4; Answers to chapter 4 (with explanations); 5. Mature B cell lymphomas, plasma cell neoplasms and Hodgkin lymphoma; Answers to chapter 5; Answers to chapter 5 (with explanations); 6. Mature T cell and NK cell neoplasms; Answers to chapter 6; Answers to chapter 6 (with explanations); Part III. Haemostasis and Coagulopathy: 7. Coagulation disorders; Answers to chapter 7; Answers to chapter 7 (with explanations).

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Book Synopsis

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Book SynopsisProvides a core knowledgebase for those with minimal exposure to hematologic molecular biology, fully revised and updated Molecular Hematology brings together the most up-to-date and reliable information on the molecular basis of major hematologic diseases. Edited and authored by leading experts in the field, this volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders. Concise, accessible chapters address key topics in modern hematology, such as lymphoma genetics, molecular coagulation, thrombophilia, pharmacogenomics, platelet disorders, hemophilia, anemia, and multiple myeloma. Chapters introduce and summarize specific hematologic diseases, explore the pathogenesis of the disorder, highlight new and emerging molecular strategies, and more. Now in its fifth edition, Molecular Hematology is fully revised to incorporate contemporary hematology research and practice. Entirely new chapters cover topic

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Book SynopsisThis new textbook has an international authorship and is a practical, up-to-date resource for clinicians responsible for the care of children with oncologic and malignant hematologic disease. Itis specifically designed for practicing oncologists and hematologists, pediatricians with an interest in childhood cancer and trainees seeking a systematic approach to these disorders. This new textbook has an emphasis on the visual presentation and ease of reading of contemporary and comprehensive information for children's cancers and contains detailed tables, fact boxes and illustrations. The textbook begins with an introduction to the general principles of the scientific foundation and treatment of childhood cancers and hematological malignancies. Separate sectionsare then devoted to descriptions of central nervous system tumors, hematological malignancies and solid tumors of childhood which encompass epidemiology, cellular and molecular biology, cancer genetics, immunology, pharmacologTrade Review“It is compact, concise, and easy to read and understand, and certainly a useful addition to the field.” (Doody's, 3 August 2012) "However, overall, this is a useful book, probably most useful for paediatricians who may be providing shared care for paediatric oncology patients, junior doctors on haematology/oncolgy ward." (The Bulletin of the Royal College of Pathologists, 1 July 2011)Table of ContentsContributors. 1 Introduction (Edward J. Estlin, Richard J. Gilbertson and Robert F. Wynn). Part I Central Nervous System Tumors of Childhood. 2 Low- and High-Grade Glioma (Ian F. Pollack). 3 Ependymoma (Thomas E. Merchant and Richard J. Gilbertson). 4 Embryonal Tumors (Amar Gajjar and Steven C. Clifford). 5 Pediatric Spinal Cord Tumors (Annie Huang, Ute Bartels and Eric Bouffet). 6 Pediatric Craniopharyngioma, Mixed Glioneuronal Tumors, and Atypical Teratoid/Rhabdoid Tumor (Adrienne Weeks and Michael D. Taylor). Part II Hematological Disorders. 7 Acute Lymphoblastic Leukemia (Robert F. Wynn). 8 Acute Myeloid Leukemia and Myelodysplastic Disorders (David K.H. Webb). 9 Non-Hodgkin’s Lymphoma (Angelo Rosolen and Lara Mussolin). 10 Hodgkin's Lymphoma (Wolfgang Dörffel and Dieter Körholz). 11 Histiocytic Disorders (Sheila Weitzman and R. Maarten Egeler). Part III Solid Tumors of Childhood. 12 Neuroblastoma (Sucheta J. Vaidya and Andrew D. J. Pearson). 13 Renal Tumors (Edward J. Estlin and Norbert Graf). 14 Soft Tissue Sarcoma (Gianni Bisogno and John Anderson). 15 Bone Tumors (Richard Gorlick, Martha Perisoglou and Jeremy Whelan). 16 Hepatic Tumors (Penelope Brock, Derek J. Roebuck and Jack Plaschkes). 17 Germ Cell Tumors (James Nicholson and Roger Palmer). 18 Retinoblastoma (Edward J. Estlin, François Doz and Michael Dyer). 19 Rare Tumors (Bernadette Brennan and Charles Stiller). Part IV Supportive Care, Long-Term Issues, and Palliative Care. 20 Supportive Care: Physical Consequences of Cancer and its Therapies (Bob Phillips and Roderick Skinner). 21 Psychosocial Needs of Children with Cancer and Their Families (Ged Lalor and Louise Talbot). 22 Late Effects in Relation to Childhood Cancer (Louise Talbot and Helen Spoudeas). 23 Palliative Care (Lynda Brook). 24 Clinical Trials Involving Children with Cancer – Organizational and Ethical Issues (Sue Ablett and Edward J. Estlin). Index. Colour plate.

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Book SynopsisMeeting the needs of patients while minimizing blood transfusions requires special expertise, precise monitoring and innovative techniques. This cutting-edge resource covers all the important clinical aspects of transfusion medicine in diverse clinical settings, with a special emphasis on alternatives to transfusion. Edited by a multidisciplinary team consisting of a transfusion specialist, an anesthesiologist and an intensive care specialist this book is endorsed by the Network for Advancement of Transfusion Alternatives. The contributors review the appropriate use of fluids and of blood products, and describe the latest treatment options available to decrease the need for allogeneic blood products including: Argon beam Cell saver Harmonic scalpel Normovolemic haemodilution Synthetic erythropoietin Antifibrinolytics Recombinant factor VIIa Advanced monitoring of hemostasis Intravenous iron Trade Review"It would be of great interest to students or practitioners in laboratory and/or transfusion medicine, anesthesiology, and surgery interested in alternatives to blood transfusion. The editors and authors are credible authorities in their fields." (Doody's, 9 September 2011) "The book provides the state of the art in blood transfusion management and I shall certainly be referring to it often as I continue to develop a blood conservation programme in my own hospital." (The Bulletin of the Royal College of Pathologists, 1 July 2011) Table of ContentsContributors List ix Part 1 History and Development of Transfusion Medicine 1 1 From Blood Transfusion to Transfusion Medicine 3Alice Maniatis Part 2 Allogeneic Blood Usage—Risks and Benefits 9 2 Allogeneic Blood Components 11Rebecca Cardigan & Sheila MacLennan 3 Current Information on the Infectious Risks of Allogeneic Blood Transfusion 21Alan D. Kitchen & John A. J. Barbara 4 Immunological Complications of Blood Transfusion 31Clare Taylor Cristina Navarrete & Marcela Contreras 5 Immunomodulation and Allogeneic Blood Transfusion 47Marloes Waanders Leo Van De Watering & Anneke Brand 6 Pathogen Inactivation of Blood Components 60Chris Prowse 7 The Benefits of Allogeneic Erythrocyte Transfusion: What Evidence Do We Have? 68Neil Soni & Benjamin Thomas Part 3 Volume Replacement 83 Section 1 Plasma and Albumin 85 8 Plasma and Albumin 87Philippe L. Baele Section 2 Crystalloids and Synthetic Colloids 109 9 Pharmacology of Intravenous Fluids 111Michael F.M. James 10 Crystalloids versus Colloids: The Controversy 119Hengo Haljamäe 11 Effects of Synthetic Colloids on Hemostasis 137Sibylle A. Kozek-Langenecker & Gisela Scharbert 12 Hydroxyethyl Starch and Renal Dysfunction 150Laurent Jacob Nicholas Heming & Bertrand Guidet 13 Choice of a Synthetic Colloid for Surgery 158Joachim Boldt 14 Choice of Colloid for Intensive Care Patients 168Yasser Sakr & Yalcin Inel 15 Hypertonic Saline Solutions for the Initial Treatment of Patients with Traumatic Injuries 179Charles E. Wade & Michael A. Dubick 16 Hyperchloremic Acidosis 194Edward Burdett & Andre Vercueil Part 4 Tolerance of Anemia 203 17 Basic Principles of Oxygen Transport and Calculations 205Jean-Louis Vincent Pongdhep Theerawit & Davide Simion 18 Assessment of Tissue Oxygenation 210Michael Piagnerelli Ann Dierick & Philippe Van der Linden 19 Tissue Oxygenation and Blood Transfusion 218Stefan Suttner & Joachim Boldt 20 Anemia and Cardiovascular Disease 229Antonis S. Manolis Spyridon Koulouris Kostas Triantafyllou Dimitris Sakellariou Sokratis Pastromas & Helen Melita Part 5 Perioperative Hemostasis 253 21 Monitoring of Hemostasis in the Perioperative Setting 255Sibylle A. Kozek-Langenecker & Eva Schaden 22 Antifibrinolytics in Open-Heart Surgery 267Wulf Dietrich 23 Efficacy and Safety of Recombinant Activated Factor VII to Control Bleeding in Nonhemophiliac Patients 278Jean-François Hardy Sylvain Bélisle & Philippe Van der Linden Part 6 Transfusion Triggers 293 24 Role of Hemoglobin/Hematocrit 295Kristine J. Guleserian Hae W. Kim Bruce Pearce Arkadiy Pitman & A. Gerson Greenburg 25 Calculation of Blood Loss 303Mark E. Brecher 26 Management of Massive Transfusion 313Jean-François Hardy & Marc Samama Part 7 Alternatives to Allogeneic Blood Transfusion 329 Section 1 Pharmaceutical Approaches 331 27 Iron Deficiency: Causes Diagnosis and Management 335Manuel Muñoz José Antonio García-Erce & Elvira Bisbe 28 Current Status of Perisurgical Erythropoietin Therapy 350Lawrence T. Goodnough 29 Erythropoietin and Iron Therapy in Patients with Renal Failure 357Lucia Del Vecchio & Francesco Locatelli 30 Hemoglobin-based Blood Substitutes 368G. Deby-Dupont Bernadette Remy & Maurice Lamy 31 Perfluorocarbon Emulsions 380Pedro Cabrales Section 2 Surgical Techniques 389 32 Minimally Invasive Cardiac Surgery: Impact on Blood Loss and Transfusion 391He Tao & Fraser Rubens 33 Adjunctive Strategies to Impact Blood Transfusion in Cardiac Surgery 408L. Ressler & Fraser Rubens Section 3 Anesthetic Techniques 419 34 Anesthetic Techniques to Reduce Blood Loss 421Dafydd Thomas 35 Controlled Hypotension Decreases Blood Transfusion Requirement: Fact or Fallacy? 430Richard P. Dutton 36 Acute Normovolemic Hemodilution 439Javad Bidgoli & Philippe Van der Linden 37 Hyperoxic Hemodilution 450Jens Meier Konrad Messmer & Oliver Habler 38 Intraoperative and Postoperative Cell Salvage 458Ernil Hansen & Hans Gombotz Section 4 Special Settings 475 39 Anemia and Red Blood Transfusion in Critical Care 477Tim Walsh 40 Red Blood Cell Transfusions and Alternatives to Treat the Anemia of Prematurity 490Ronald G. Strauss 41 Transfusion Alternatives in Orthopedic Surgery 498Manuel Muñoz José Antonio García-Erce & Jorge Cuenca 42 Transfusion Alternatives in Obstetrics 509Christian Breymann Part 8 Legal and Ethical Issues in Transfusion Medicine 521 43 Ethical Aspects of Informed Consent: American Models 523Ronald E. Domen 44 Blood Transfusions Jehovah’s Witnesses and the American Patients’ Rights Movement 531Charles H. Baron Part 9 Cost Issues 557 45 The Cost and Cost-Effectiveness of Allogeneic and Autologous Blood 559Brian Custer 46 Autologous Blood Predonation in Cardiac Surgery 569Wulf Dietrich 47 Cost-Effectiveness of Pharmacological Alternatives 575Dean Fergusson & Brian Hutton Index 581

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Book SynopsisHaematology Nursing is a comprehensive handbook, with a nursing focus, on the care and management of patients with haematological disorders. Divided into four sections, the first provides an introduction to haematology, looking at haemopoiesis, immunology and genetics.Table of ContentsContributors vii Foreword x Section 1 Introduction to Haematology 1 1 Understanding Haemopoiesis 3 Marvelle Brown 2 Immunology 22 Jane Richardson and Tracey Cutler 3 Genes and Haematology 37 Gwyneth Morgan 4 The Cell 50 Louise Knight Section 2 Non-Malignant Haematology 61 Anaemia 5 Aplastic Anaemia: Pathophysiology, Care and Management 63 Audrey Yandle 6 Nutritional Anaemia: Pathophysiology, Care and Management 79 Marvelle Brown 7 Acquired Haemolytic Anaemia: Pathophysiology, Care and Management 96 Marvelle Brown 8 Inherited Haemolytic Anaemia: Pathophysiology, Care and Management 107 Marvelle Brown Haemoglobinopathies 9 Sickle Cell Disease and Thalassaemia: Pathophysiology, Care and Management 117 Marvelle Brown Haemochromatosis 10 Haemochromatosis: Pathophysiology, Care and Management 150 Jan Green Section 3 Myeloproliferative and Lymphoproliferative Disorders 163 11 Polycythaemia: Pathophysiology, Care and Management 165 Marvelle Brown 12 The Myelodysplastic Syndromes: Pathophysiology, Care and Management 171 Jackie Green 13 Acute Leukaemia: Pathophysiology, Care and Management 183 Jackie Green 14 Chronic Leukaemia: Pathophysiology, Care and Management 195 Samantha Toland 15 Multiple Myeloma: Pathophysiology, Care and Management 202 Marvelle Brown 16 Lymphoma: Pathophysiology, Care and Management 217 Tracey Cutler Section 4 Nursing Care Interventions 233 17 Blood Transfusion 235 Jan Green 18 Venous Access Devices 261 Janice Gabriel 19 Chemotherapy and Monoclonal Antibodies 275 Alison Simons and Tracey Cutler 20 Haemopoietic Stem Cell Transplant 287 Tracey Cutler 21 Palliative Care in Haematology 300 Dion Smyth Glossary of Terms 314 Index 317

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Book SynopsisA vital resource on blood and bone marrow cell morphology in laboratory animal medicine. This fully revised new edition is an essential reference for clinical pathologists in diagnostic laboratories, and medical or veterinary research. The atlas contains over 400 color images of cells from the peripheral blood and bone marrow from a variety of animals encountered in laboratory animal medicine, in health and disease. Key features: New chapter on flow cytometry and its application in terms of routine analyses as a means of identifying abnormalities in cell marker expression, which is of particular relevance for pre-clinical safety assessment Covers the most recent developments in laboratory animal hematology, including parameters measured by the latest generation of analyzers Coverage of a wide range of laboratory animal species, as well as those used in clinical veterinary trials Photomicrographs present normal and abnormal blood cells from a Trade Review“This book may not be useful for the typical veterinary student or practitioner, but it is an excellent resource for those involved in preclinical studies on toxicosis.” (Journal of The American Veterinary Medical Association, 15 June 2012) "A fine college reference!." (The Midwest Book Review, 1 November 2011)Table of ContentsForeword vii Introduction ix Dedication xi Acknowledgments xiii 1 Rodents 1 Mouse 1 Introduction 1 Blood picture 1 Typical ranges (Siemens Advia 120) 2 Hamster 15 Introduction 15 Blood picture 15 Guinea Pig 17 Introduction 17 Blood picture 17 Rat – Sprague Dawley (SD)/Han Wistar (HW) 18 Introduction 18 Blood picture 18 Typical ranges (Siemens Advia 120) 19 References 36 2 Rabbit 37 Introduction 37 Blood picture 37 References 39 4 Dog 45 Introduction 45 Blood picture 45 Typical ranges (Siemens Advia 120) 46 References 64 5 Monkey 65 Introduction 65 Blood picture 65 Marmoset 66 Cynomolgus 71 Introduction 71 Blood picture 71 Typical ranges (Siemens Advia 120) 72 Baboon 84 Rhesus Monkey 86 References 87 6 Other species 89 Pig 89 Introduction 89 Blood picture 89 Horse 91 Introduction 91 Blood picture 91 Goat and Sheep 94 Assorted Other Species 96 References 103 3 Cat 41 Introduction 41 Blood picture 41 References 44 7 Blood collection procedures 105 Common bleeding sites 105 Anticoagulants 105 Staining 105 8 Artifacts 107 Collection artifacts 107 Sample transport and storage 109 Anticoagulant 110 Storage artifacts 111 Blood smear preparation 113 Stain precipitate 113 References 114 9 Bone marrow 115 Introduction 115 Review of marrow sampling techniques 115 Recommended methods for marrow sampling 116 Preparation and staining of smears 118 Evaluation 119 Interpretation 119 References 120 10 Comparative applications in flow cytometry 121 Application of flow cytometry in comparative hematology 122 References 132 Index 135

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Book SynopsisEdited by experts from one of the world's largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Chapters covering new treatments present an outlook for the future and explain the rationale for ongoing clinical trials. Topics include: Targeted therapy, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, kit inhibitors, BCR-ABL inhibitors) Ras inhibitors Epigenetic therapy (hypomethylaters and histone deacetylase inhibitors) Lenalidomide analogs New chemotherapy drugs, e.g. clofarabine, cloretazine, sapacitabine, forodesine Combinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols in combination with dasatinib or imatinib) New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40) Thrombopoietic agents Leukemias: PrinciplTrade Review"This high quality book will be an excellent reference for both fellows and attending physicians who care for patients with leukemic disorders in either a community or academic setting . . . This book is a welcome resource for those entering the field as well as for long-time practitioners who want to stay up to date." (Doody's, 12 August 2011)Table of ContentsContributors. Preface. Part 1: Background and Diagnostic. 1. Stem Cell Biology in Normal and Malignant Hematopoiesis (Amer Zeidan and Meir Wetzler). 2. Epidemiology and Etiology of Leukemias (Andrew Fletcher, Annika Whittle and David Bowen). 3. Traditional Diagnostic Approaches (Hartmut Koeppen, Carlos E. Bueso-Ramos and Sergej N. Konoplev). 4. Diagnosis of Leukemias - New Diagnostic Modalities and Implications for Classification (Maher Albitar). 5. Non-cytogenetic Markers and Their Impact on Prognosis (Eric Schafer and Donald Small). Part 2: Myelodysplastic syndromes (MDS). 6. Myelodysplastic Syndromes: Pathophysiology (Steven D. Gore and Erica Warlick). 7. Myelodysplastic Syndromes - The Role of Cytogenetic and Molecular Abnormalities for Classification and Risk Assignment (Ulrich Germing). 8. Myelodysplastic Syndromes (William Stevenson and Guillermo Garcia-Manero). Part 3: Acute Myeloid Leukemia (AML). 9. Presentation and Diagnosis: Novel Molecular Markers and their Role in the Prognosis and Therapy of Acute Myeloid Leukemia (Wolfgang Kern, Torsten Haferlach, Susanne Schnittger, Claudia Haferlach, and Ulrike Bacher). 10. Induction Therapy of Acute Myeloid Leukemia (Martha Wadleigh and Daniel J. DeAngelo). 11. Salvage Therapy for Acute Myeloid Leukemia: Current Strategies and Emerging Therapies (Keith W. Pratz and Judith E. Karp). 12. Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia (Gheath Alatrash and Marcos de Lima). Part 4: Acute Promyelocytic Leukemia (APL). 13. The Pathophysiology of Acute Promyelocytic Leukemia (Francesco Lo-Coco and Syed Khizer Hasan). 14. Acute Promyelocytic Leukemia (APL): Manifestations and Therapy (Sylvain Thépot, Lionel Ades, Pierre Fenaux). Part 5: Acute Lymphoblastic Leukemia (ALL). 15. Acute Lymphoblastic Leukemia: Presentation, Diagnosis and Classification (Sandeep Gurbuxani and John Anastasi). 16. Induction Therapy in Adult Acute Lymphoblastic Leukemia (Xavier Thomas). 17. Salvage Therapy of Adult Acute Lymphoblastic Leukemia (Nicola Gökbuget and Dieter Hoelzer). 18. Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Current Treatment Status and Perspectives (Olga Sala-Torra and Jerald P. Radich). 19. Acute Lymphoblastic Leukemia in Adolescents and Young Adults (Michael E. Rytting). 20. The Role of Hematopoietic Stem Cell Transplantation in Adults with Acute Lymphoblastic Leukemia (Partow Kebriaei). Part 6: Chronic Myeloid Leukemia (CML). 21. Pathophysiology of Chronic Myeloid Leukemia (Agnes S. M. Yong and Junia V. Melo). 22. Therapy of Newly Diagnosed and Chronic Phase Chronic Myelogenous Leukemia (Andreas Hochhaus). 23. Therapy of Advanced Stage and Resistant Chronic Myeloid Leukemia (Devendra K. Hiwase and Timothy P. Hughes). Part 7: Chronic Lymphocytic Leukemia. 24. Chronic Lymphocytic Leukemia: Pathophysiology, Diagnosis and Manifestations, and Prognostic Markers (Thorsten Zenz, Hartmut Döhner, Stephan Stilgenbauer). 25. Therapy of Chronic Lymphocytic Leukemia – Frontline and Salvage (Valentin Goede, Barbara Eichhorst, and Michael Hallek). 26. The Role of Stem Cell Transplantation in Chronic Lymphocytic Leukemia (Simon Hallam and John G. Gribben). 27. Special Situations: Management of Elderly Patients and CLL Transformation (Wei-Gang Tong and Alessandra Ferrajoli). Part 8: Other Leukemic Disorders. 28. Hairy Cell Leukemia (Farhad Ravandi). 29. Therapeutic Approaches to the Mature T-cell Lymphoproliferative Leukaemias (Nnenna Osuji and Claire Dearden). 30. Philadelphia Chromosome Negative Myeloproliferative Neoplasms (Ruben A. Mesa and Srdan Verstovsek). Part 9: General Treatment Principles and Clinical Developments. 31. Management of Emergencies in Leukemias (Olga Frankfurt). 32. Management of Infectious Complications in Patients with Leukemia (Marcio Nucci, Nair Bijay and Elias Anaissie). 33. Transfusion Support and Hematopoietic Growth Factors (Paolo Rebulla). 34. New Designs for Clinical Trials: AML as an Example (Elihu Estey). Index. The color plate section.

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Book Synopsis* A comprehensive guide on recent developments in the molecular diagnosis and treatment of hematological malignancies * Contains practical information on current treatment strategies and covers future developments in the field * Fully illustrated .Trade Review"This book provides a concise overview of topics in malignant hematology. The charts and tables offer excellent, quick reviews of topics. In addition, the contributors appear to be well-respected authorities in the field." (Doody's, 2 September 2011) Table of ContentsPart 1: Hematopoiesis. 1 Normal and Malignant Hematopoiesis (Bijal D. Shah and Kenneth S. Zuckerman). 2 The Leukemic Genome (Jonathan C. Strefford and Nicholas CP Cross). Part 2: Myeloid Malignancies. 3 Myeloproliferative Neoplasms (Ruben A. Mesa and Ayalew Tefferi). 4 CML: Molecular Biology of BCR-Able (Javier I. Pinilla-Ibarz, Eric Padron and Lori Hazlehurst). 5 Standard Management of Patients with CML (Chronic Myeloid Leukemia) (Elias Jabbour, Jorge Cortes and Hagop Kantarjian). 6 The Molecular Biology of Acute Myeloid Leukemia (Jerald Radich). 7 Acute Myeloid Leukemia (Martin S. Tallman, Ritesh Parajuli and Jessica K. Altman). 8 Acute promyelocytic leukemia (APL) (Sylvain Thépot, Lionel Ades and Pierre Fenaux). 9 A Pluralistic approach to the study of myelodysplastic syndromes: Evolving pathology of the Seed via the Soil (Naomi Galili, Raymond Cruz, Jamie Stratton, Jessica Clima, Ghulam Sajjad Khan and Azra Raza). 10 Myelodysplastic Syndrome: A Review of Current Care (Kenneth H. Shain, Alan F. List and Rami S. Komrokji). 11 Supportive Care in Myelodysplastic Syndrome (MDS) (Hussain I. Saba, Arshia A. Dangol and Donald C. Doll). Part 3: Lymphoid Malignancies. 12 Molecular Biology of Chronic Lymphoproliferative Disorders (Monique A. Hartley and Lubomir Sokol). 13 Chronic Lymphocytic Leukemia (Terry Hamblin and Angela Hamblin). 14 Acute Lymphoblastic Leukemia (Susan O'Brien, Stefan Faderl, Deborah Thomas and Hagop M. Kantarjian). 15 Large Granular Lymphocyte Leukemia (Xin Liu and Thomas P. Loughran, Jr.). 16 Hairy Cell Leukemia (Kevin T. Kim, Darren S. Sigal and Alan Saven). 17 Molecular Basis of B-cell Lymphomas (Elizabeth M. Sagatys, Eduardo M. Sotomayor and Jianguo Tao). 18 Non-Hodgkin’s Lymphomas (Peter McLaughlin and Nathan Fowler). 19 Hodgkin Lymphoma (Michael Crump). Part 4: Plasma Cell Disorders. 20 Multiple Myeloma: Molecular Biology, Diagnosis and Treatment (S. Vincent Rajkumar and Shaji Kumar). 21 Waldenström’s Macroglobulinemia (Robert A. Kyle and Suzanne Hayman). 22 Primary Systemic (AL) Amyloidosis (Efstathios Kastritis and Meletios Athanasios Dimopoulos). Part 5: Bone Marrow Transplantation and Quality of Life. 23 Advances in allogeneic hematopoietic cell transplantation: progress in transplantation technology and disease-specific outcomes (Joseph Pidala and Claudio Anasetti). 24 Quality of Life after the diagnosis of Hematological Malignancies (Mohamed Sorror).

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Book SynopsisIronically, transforming the hope of a normal life into a purchasable commodity for people with bleeding disorders made it all too easy to ignore the potential dangers of delivering greater health and autonomy to hemophilic boys and men.Trade ReviewThe author's research was impeccable and he writes in a very readable manner. Book Bargains and Previews This book holds wide appeal for both lay readers and medical professionals who are interested in the history of medicine, the ability of technology development to produce both good and bad outcomes, and the influence of societal perceptions on health policy and technology development. -- Bruce L. Evatt Journal of Clinical Investigation A thoughtful, intelligent, and informative contribution to the history of hemophilia and the shaping of safety policies in blood use. Choice Few stories in modern medicine oscillate as dramatically between triumph and tragedy as the history of hemophilia. The Bleeding Disease combines classic history of science with sociological analysis to tell this story in a style that should appeal to both medical and lay audiences. -- Katherine A. High Nature Medicine Excellent. -- Chris Feudtner Bulletin of the History of Medicine A well-researched, readable, and useful history of hemophilia in the United States, contextualized within its scientific, social, and economic milieu... Pemberton's book will serve as an inspiration and a cautionary tale about medical 'progress' writ large. -- Jacalyn Duffin Canadian Bulletin of Medical History A great read for everyone interested in scientific development, technological progress and the management of disease. The Good Care Guide Provides a thorough and detailed history of hemophilia. -- William G. Rothstein History of Science Society A really good review of the historical developments of medicine within a particular clinical condition. -- Ibadete Fetahu Nursing Times A great read for everyone interested in scientific development, technological progress and the management of disease. Nursing Standard A well-researched and compelling history of hemophilia. This book will undoubtedly be a standard for future histories in this area. -- Richard Nollan Journal of the History of Medicine and Allied Sciences A meticulously researched and consistently argued work of scholarship... The Bleeding Disease is a significant contribution to the history of biomedicine. -- Peter Hobbins Metascience The Bleeding Disease makes an important contribution to the history of American biomedicine in the twentieth century. -- Sophie Chauveau Medical History The Bleeding Disease is a welcome addition to the literature of that crisis and the history of haemophilia that preceeded it... This Faustian story has been told before; Pemberton enriches he telling not by seeking to blame the companies, the doctors or the regulators but by emphasising the desire for haemophiliacs to have normal lives. It is a dream shared by sufferers of any disease that have made the transition from deadly to chronic from diabetes to AIDS. Social History of Medicine Pemberton has done an admirable job of showing us the vast potential, and substantial limitations, of medical science to solve health problems... This book is strongly recommended for those studying the history of medicine, the history of medical technology, and the sociology of medicine. -- Stephen Inrig American Historical ReviewTable of ContentsPrefaceAcknowledgmentsIntroduction: Hemophilia as Pathology of Progress1. The Emergence of the Hemophilia Concept2. The Scientist, the Bleeder, and the Laboratory3. Vital Factors in the Making of a Masculine World4. Normality within Limits5. The Hemophiliac's Passport to Freedom6. Autonomy and Other Imperatives of the Health Consumer7. The Mismanagement of Hemophilia and AIDSConclusion: The Governance of Clinical Progress in a Global AgeNotesIndex

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Book SynopsisThis guide is essential for health professionals seeking more information about this underdiagnosed disease.Trade ReviewThis book is an excellent basic overview of HHT. It describes the condition, the difficulties often found in diagnosis, current and potential future treatments, as well as emotional and social effects for both patients and their families along with coping strategies. Throughout, the ability to live well with knowledge and appropriate care is emphasized.—Jeffrey Pollak, MD, Katharine Henderson, MS, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, Journal of Radiology NursingTable of ContentsAcknowledgmentsIntroductionPart I1. Diagnosis2. The Trouble with Telangiectasias3. HHT's Hidden DangersPart II4. Taking Care of Yourself5. Taking Care of Your Family6. Beyond the FamilyPart III7. Frontiers in HHT ResearchNotesGlossaryResourcesIndex

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Book SynopsisA comprehensive, down-to-earth guide for anyone diagnosed with breast cancer. Being diagnosed with breast cancer can be scary and confusing. There are medical terms to learn, options to consider, and important decisions to make, all while trying to carry on with work, family, and life. The Breast Cancer Book can't reverse a diagnosis or make breast cancer disappear, but every page can inform and empower you or your loved ones, no matter where you are in the breast cancer experience. Written by three trusted expertsan oncologist, a breast surgeon, and a two-time breast cancer survivorthis multidisciplinary book walks you through everything you need to know about breast cancer so that you can make the best decisions about diagnosis, treatment, and follow-up care. In plain, easy-to-understand language that illuminates all the facets of this disease, the authors draw on their professional experience and the most current scientific knowledge to describe the risk factors for breast cancer;Trade ReviewThis book is written thoughtfully and empathetically and I would urge you to read it if you've received this frightening diagnosis.—Dr. Kathleen Thompson, author of From Both Ends of the Stethoscope:Getting through breast cancer – by a doctor who knows, Frost MagazineTable of ContentsList of TablesIntroduction A Message of HopePart One. Understanding Breast Cancer1. What Is Cancer?2. Breast Cancer Basics3. Demystifying Breast Cancer Risk4. Strategies to Reduce Your Risk of Developing Breast Cancer5. Hereditary Breast CancerPart Two. Finding Breast Cancer and Dealing with a Diagnosis6. Screening Tools and Technologies7. Making a Diagnosis8. After a Diagnosis: Charting a Course and Assembling Your TeamPart Three. Understanding Treatment Choices and Making Decisions9. Local Therapy: Breast Cancer Surgery10. Radiation Therapy11. Rebuilding Your Breasts after Mastectomy12. Treating Noninvasive Breast Cancer: Ductal Carcinoma In Situ13. Reducing the Risk of Recurrence: Systemic Therapies for Invasive Breast Cancer14. Cancer Again: Treating Local or Regional Recurrence15. Treating Metastatic Breast Cancer16. Considering Breast Cancer Clinical Trials17. Treating Less Common Types of Breast Cancers and Male Breast CancerPart Four. Finding Answers18. Managing Breast Cancer Treatment Side Effects19. Complementary, Integrative, and Alternative Medicine20. Meeting the Emotional Challenges of Breast Cancer21. Family Matters during and after Breast Cancer22. Insurance and Money Matters during Breast Cancer TreatmentPart Five. Moving On23. Supportive Care and Symptom Management for Women with Metastatic Breast Cancer24. Living Well beyond Cancer: Healthy Breast Cancer SurvivorshipResourcesGlossaryIndex

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Book SynopsisA comprehensive, down-to-earth guide for anyone diagnosed with breast cancer. Being diagnosed with breast cancer can be scary and confusing. There are medical terms to learn, options to consider, and important decisions to make, all while trying to carry on with work, family, and life. The Breast Cancer Book can't reverse a diagnosis or make breast cancer disappear, but every page can inform and empower you or your loved ones, no matter where you are in the breast cancer experience. Written by three trusted expertsan oncologist, a breast surgeon, and a two-time breast cancer survivorthis multidisciplinary book walks you through everything you need to know about breast cancer so that you can make the best decisions about diagnosis, treatment, and follow-up care. In plain, easy-to-understand language that illuminates all the facets of this disease, the authors draw on their professional experience and the most current scientific knowledge to describe the risk factors for breast cancer;Trade ReviewThis book is written thoughtfully and empathetically and I would urge you to read it if you've received this frightening diagnosis.—Dr. Kathleen Thompson, author of From Both Ends of the Stethoscope:Getting through breast cancer – by a doctor who knows, Frost MagazineTable of ContentsList of TablesIntroduction A Message of HopePart One. Understanding Breast Cancer1. What Is Cancer?2. Breast Cancer Basics3. Demystifying Breast Cancer Risk4. Strategies to Reduce Your Risk of Developing Breast Cancer5. Hereditary Breast CancerPart Two. Finding Breast Cancer and Dealing with a Diagnosis6. Screening Tools and Technologies7. Making a Diagnosis8. After a Diagnosis: Charting a Course and Assembling Your TeamPart Three. Understanding Treatment Choices and Making Decisions9. Local Therapy: Breast Cancer Surgery10. Radiation Therapy11. Rebuilding Your Breasts after Mastectomy12. Treating Noninvasive Breast Cancer: Ductal Carcinoma In Situ13. Reducing the Risk of Recurrence: Systemic Therapies for Invasive Breast Cancer14. Cancer Again: Treating Local or Regional Recurrence15. Treating Metastatic Breast Cancer16. Considering Breast Cancer Clinical Trials17. Treating Less Common Types of Breast Cancers and Male Breast CancerPart Four. Finding Answers18. Managing Breast Cancer Treatment Side Effects19. Complementary, Integrative, and Alternative Medicine20. Meeting the Emotional Challenges of Breast Cancer21. Family Matters during and after Breast Cancer22. Insurance and Money Matters during Breast Cancer TreatmentPart Five. Moving On23. Supportive Care and Symptom Management for Women with Metastatic Breast Cancer24. Living Well beyond Cancer: Healthy Breast Cancer SurvivorshipResourcesGlossaryIndex

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Book SynopsisThe most comprehensive guide available on hereditary cancers, from understanding risk, prevention, and genetic counseling and testing to treatment, quality of life, and more. Up to 10 percent of cancers are caused by inherited mutations in specific genes. Finding out that you or your loved ones may be at increased risk of developing cancer because of a genetic mutation raises a lot of questions: Is cancer inevitable? Is there anything I should do differently in my life? Will my children also be at higher risk of cancer? Should I have preemptive treatments or surgery? This comprehensive guide provides answers to these questions and more. Written by three passionate patient advocates, this book is a compilation of the trusted information and support provided for more than two decades by Facing Our Risk of Cancer Empowered (FORCE), the de facto voice of the hereditary cancer community. Combining the latest scientific research with national guidelines, expert advice, and compelling patieTable of ContentsList of TablesForeword, by Matthew Boland Yurgelun, MDIntroductionPart I. Understanding Cancer and Inherited Risk1. The Link between Genetics and CancerThe Basics of GeneticsGene Wear and Tear and Repair How Cancers Develop and Grow Most Cancers Aren't Caused by Inherited Mutations2. What's Swimming in Your Gene Pool?Hidden Risk in the Family TreePlotting Your Genetic Pedigree3. Signs of Hereditary CancerThe Value of Genetic Counseling Making Decisions about Testing Insurance CoveragePrivacy and Protection4. What Your Test Results Tell YouPositive, Negative, Maybe Making Sense of StatisticsYou Have a Mutation; Now What?Part II. Inherited Gene Mutations and the Cancers They Cause5. Introducing BRCA1 and BRCA2Who Inherits a BRCA Mutation?Signs of a BRCA MutationLevels of Risk6. Lynch Syndrome: Five Genes, One Hereditary SyndromeSigns of Lynch Syndrome in FamiliesLevels of Risk7. Other Genes That Are Linked to Inherited Cancer RiskLess Known, Less Studied Genes8. Breast Cancer BasicsSigns and SymptomsWhat Affects Breast Cancer Risk?Types of Breast Cancer9. Gynecologic CancersOvarian, Fallopian Tube, and Primary Peritoneal CancersEndometrial Cancers10. Gastrointestinal CancersColorectal CancerSmall Bowel CancerPancreatic CancerStomach CancerAnal Cancer11. Genitourinary CancersProstate CancerBladder, Ureter, and Renal Pelvis Cancers12. MelanomaMelanoma of the SkinOcular MelanomaPart III. Strategies for Risk Reduction and Early Detection13. Risk Management GuidelinesGuidelines for BRCA1 or BRCA2 Gene MutationsGuidelines for Lynch Syndrome Gene MutationsGuidelines for Mutations in Other Genes14. Early Detection Strategies for High-Risk PeopleThe Vocabulary of ScreeningSurveillance for Breast CancerSurveillance for Gynecologic CancersSurveillance for Gastrointestinal CancersSurveillance for Prostate and Other Genitourinary Cancers Surveillance for MelanomaScreening for Other Hereditary Cancers15. Medications That Reduce Cancer RiskRisk-Reducing Medications for Breast CancerRisk-Reducing Medications for Gynecologic CancersRisk-Reducing Medications for Colorectal Cancers16. Surgeries That Reduce Breast Cancer RiskMastectomy ProceduresBreast Reconstruction ChoicesSide Effects, Risks, and Recovery17. Surgeries That Reduce the Risk of Gynecologic CancersSalpingo-Oophorectomy to Reduce the Risk of Ovarian CancerHysterectomy to Reduce the Risk of Endometrial Cancer18. Surgeries That Reduce the Risk of Gastrointestinal CancersTotal and Segmental Colectomy to Reduce the Risk of Colon CancerTotal Gastrectomy to Reduce the Risk of Stomach Cancer19. Factors That Affect Cancer RiskNutrition, Weight, and Physical Activity Alcohol: An Unwise ChoiceSmoking and Tobacco ProductsOther Lifestyle and Behavioral Risk FactorsPart IV. Treatment Choices for Hereditary Cancers20. Identifying Tumor Characteristics That Inform Treatment ChoicesStaging and Grading CancerTargeted Approaches to TreatmentDNA Damage Repair Genes21. Treating Breast CancerCancer Type, Subtype, and StageBiomarker TestingGenetic TestingOptions for TreatmentFollow-Up Care22. Treating Gynecologic CancersOptions for Ovarian, Fallopian Tube, and Primary Peritoneal CancersOptions for Endometrial Cancer23. Treating Gastrointestinal CancersOptions for Colorectal CancerOptions for Pancreatic CancerOptions for Gastric Cancer24. Treating Genitourinary CancersOptions for Prostate CancerOptions for Bladder, Renal Pelvis, and Ureter Cancers25. Treating Melanoma Options for Melanoma in the SkinOptions for Ocular MelanomaPart V. Living with Inherited High Risk26. Regaining Sexual Health and IntimacyBody ImageCoping with PainReduced Sexual DesireErectile DysfunctionRebuilding Intimacy27. Effects of Prevention and Treatment on FertilityPreserving Fertility in WomenPreserving Fertility in MenOther Parenting Alternatives28. Managing MenopauseSymptoms of Early MenopauseReplacement HormonesLong-Term Side Effects29. Side Effects and Other Quality-of-Life IssuesSummarizing Side Effects by TreatmentManaging Immediate Side EffectsLong-Term Effects of Prevention and TreatmentPrevivorship, Survivorship, and Follow-Up CareEnd-of-Life Issues30. Making Difficult Decisions Start at the Beginning: Should You Be Tested?Decisions about Your Cancer RiskDecisions about TreatmentPrevention and Treatment Clinical TrialsDecision-Making in 15 Steps31. You Are Not AloneCreate a Support SystemFind Emotional StrengthPursue Financial ResourcesLook to the HorizonAcknowledgmentsGlossaryNotesResourcesIndex

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Book SynopsisThe most comprehensive guide available on hereditary cancers, from understanding risk, prevention, and genetic counseling and testing to treatment, quality of life, and more. Up to 10 percent of cancers are caused by inherited mutations in specific genes. Finding out that you or your loved ones may be at increased risk of developing cancer because of a genetic mutation raises a lot of questions: Is cancer inevitable? Is there anything I should do differently in my life? Will my children also be at higher risk of cancer? Should I have preemptive treatments or surgery? This comprehensive guide provides answers to these questions and more. Written by three passionate patient advocates, this book is a compilation of the trusted information and support provided for more than two decades by Facing Our Risk of Cancer Empowered (FORCE), the de facto voice of the hereditary cancer community. Combining the latest scientific research with national guidelines, expert advice, and compelling patieTable of ContentsList of TablesForeword, by Matthew Boland Yurgelun, MDIntroductionPart I. Understanding Cancer and Inherited Risk1. The Link between Genetics and CancerThe Basics of GeneticsGene Wear and Tear and Repair How Cancers Develop and Grow Most Cancers Aren't Caused by Inherited Mutations2. What's Swimming in Your Gene Pool?Hidden Risk in the Family TreePlotting Your Genetic Pedigree3. Signs of Hereditary CancerThe Value of Genetic Counseling Making Decisions about Testing Insurance CoveragePrivacy and Protection4. What Your Test Results Tell YouPositive, Negative, Maybe Making Sense of StatisticsYou Have a Mutation; Now What?Part II. Inherited Gene Mutations and the Cancers They Cause5. Introducing BRCA1 and BRCA2Who Inherits a BRCA Mutation?Signs of a BRCA MutationLevels of Risk6. Lynch Syndrome: Five Genes, One Hereditary SyndromeSigns of Lynch Syndrome in FamiliesLevels of Risk7. Other Genes That Are Linked to Inherited Cancer RiskLess Known, Less Studied Genes8. Breast Cancer BasicsSigns and SymptomsWhat Affects Breast Cancer Risk?Types of Breast Cancer9. Gynecologic CancersOvarian, Fallopian Tube, and Primary Peritoneal CancersEndometrial Cancers10. Gastrointestinal CancersColorectal CancerSmall Bowel CancerPancreatic CancerStomach CancerAnal Cancer11. Genitourinary CancersProstate CancerBladder, Ureter, and Renal Pelvis Cancers12. MelanomaMelanoma of the SkinOcular MelanomaPart III. Strategies for Risk Reduction and Early Detection13. Risk Management GuidelinesGuidelines for BRCA1 or BRCA2 Gene MutationsGuidelines for Lynch Syndrome Gene MutationsGuidelines for Mutations in Other Genes14. Early Detection Strategies for High-Risk PeopleThe Vocabulary of ScreeningSurveillance for Breast CancerSurveillance for Gynecologic CancersSurveillance for Gastrointestinal CancersSurveillance for Prostate and Other Genitourinary Cancers Surveillance for MelanomaScreening for Other Hereditary Cancers15. Medications That Reduce Cancer RiskRisk-Reducing Medications for Breast CancerRisk-Reducing Medications for Gynecologic CancersRisk-Reducing Medications for Colorectal Cancers16. Surgeries That Reduce Breast Cancer RiskMastectomy ProceduresBreast Reconstruction ChoicesSide Effects, Risks, and Recovery17. Surgeries That Reduce the Risk of Gynecologic CancersSalpingo-Oophorectomy to Reduce the Risk of Ovarian CancerHysterectomy to Reduce the Risk of Endometrial Cancer18. Surgeries That Reduce the Risk of Gastrointestinal CancersTotal and Segmental Colectomy to Reduce the Risk of Colon CancerTotal Gastrectomy to Reduce the Risk of Stomach Cancer19. Factors That Affect Cancer RiskNutrition, Weight, and Physical Activity Alcohol: An Unwise ChoiceSmoking and Tobacco ProductsOther Lifestyle and Behavioral Risk FactorsPart IV. Treatment Choices for Hereditary Cancers20. Identifying Tumor Characteristics That Inform Treatment ChoicesStaging and Grading CancerTargeted Approaches to TreatmentDNA Damage Repair Genes21. Treating Breast CancerCancer Type, Subtype, and StageBiomarker TestingGenetic TestingOptions for TreatmentFollow-Up Care22. Treating Gynecologic CancersOptions for Ovarian, Fallopian Tube, and Primary Peritoneal CancersOptions for Endometrial Cancer23. Treating Gastrointestinal CancersOptions for Colorectal CancerOptions for Pancreatic CancerOptions for Gastric Cancer24. Treating Genitourinary CancersOptions for Prostate CancerOptions for Bladder, Renal Pelvis, and Ureter Cancers25. Treating Melanoma Options for Melanoma in the SkinOptions for Ocular MelanomaPart V. Living with Inherited High Risk26. Regaining Sexual Health and IntimacyBody ImageCoping with PainReduced Sexual DesireErectile DysfunctionRebuilding Intimacy27. Effects of Prevention and Treatment on FertilityPreserving Fertility in WomenPreserving Fertility in MenOther Parenting Alternatives28. Managing MenopauseSymptoms of Early MenopauseReplacement HormonesLong-Term Side Effects29. Side Effects and Other Quality-of-Life IssuesSummarizing Side Effects by TreatmentManaging Immediate Side EffectsLong-Term Effects of Prevention and TreatmentPrevivorship, Survivorship, and Follow-Up CareEnd-of-Life Issues30. Making Difficult Decisions Start at the Beginning: Should You Be Tested?Decisions about Your Cancer RiskDecisions about TreatmentPrevention and Treatment Clinical TrialsDecision-Making in 15 Steps31. You Are Not AloneCreate a Support SystemFind Emotional StrengthPursue Financial ResourcesLook to the HorizonAcknowledgmentsGlossaryNotesResourcesIndex

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Book SynopsisInflammatory Diseases of Blood Vessels< Inflammatory Diseases of Blood Vessels Second Edition Inflammatory Diseases of Blood Vessels provides a comprehensive overview of the science and clinical consequences of vascular inflammation in health and disease. In recent years, considerable progress has been made in understanding different forms of vasculitis. Investigation of pathogenesis of vascular inflammation has led to improved treatments and outcomes. Surgical and transplant procedures have improved in parallel with medical therapies. These areas are extensively examined in this new edition. Inflammatory Diseases of Blood Vessels is an excellent resource for a broad readership, including clinicians, investigators and their support teams in numerous specialties e.g. rheumatology, immunology, cardiology, cardiovascular surgery, pulmonary medicine, nephrology, pathology, vascular biology, embryology and imaging.Trade Review“This book provides a comprehensive overview of the science and clinical consequences of vascular inflammation in health and disease.” (European Journal of Immunology, 1 December 2012) “Overall, this is an excellent source of information on vasculitis for physicians at any level, including practicing rheumatologists.” (Doody’s, 2 November 2012) Table of ContentsList of Contributors Preface Section I. Biology of Blood Vessels and Mechanisms of Vascular Inflammation 1 Vascular Development Domenico Ribatti and Enrico Crivellato 2 Vascular Repair Christian Troidl, Kerstin Troidl, Georg Jung, Thomas Schmitz-Rixen and Wolfgang Schaper 3 Leukocyte Trafficking Braedon McDonald and Paul Kubes 4 Dendritic Cells and Vascular Inflammation Cornelia M. Weyand 5 T Cells and Vascular Inflammation Jörg J. Goronzy 6 Autoantibodies and Vascular Inflammation A.Rutgers, J.S.F. Sanders, J.W. Cohen Tervaert, C.G.M. Kallenberg 7 Neutrophils and Vascular Inflammation Matthew David Morgan and Caroline OS Savage 8 Cytokines and Vascular Inflammation Maria C Cid, Marc Corbera-Bellalta, Ester Planas-Rigol, Ester Lozano, Georgina Espígol-Frigolé, Ana García-Martínez, José Hernández-Rodríguez, Marta Segarra 9 Oxidative Stress and Vascular Inflammation David G. Harrison 10 Hemostasis and Vascular Inflammation Lawrence Leung and John Morser 11 Animal Models of Vasculitis Masato Nose 12 Arteries, Smooth Muscle Cells, and Genetic Causes of Thoracic Aortic Aneurysms Amy J. Reid and Dianna M. Milewicz 13 Innate Immunity in Atherosclerosis Shuang Chen, Prediman K. Shah and Moshe Arditi 14 Adaptive Immunity in Atherosclerosis Jan Nilsson Section II. Primary Autoimmune Vascular Diseases 15 Historical Perspectives Vasculitis Eric L. Matteson 16 Approach to the Differential Diagnosis of Vasculitis Eamonn S. Molloy and Carol A. Langford 17 Imaging of medium and large vessels (CT/PET/MR) Thorsten Alexander Bley 18 Kawasaki disease Rae S.M. Yeung 19 Henoch-Schonlein Purpura Philip J. Hashkes and Alexandra Villa-Forte 20 Polyarteritis Nodosa Eli M. Miloslavsky and John H. Stone 21 Microscopic polyangiitis Coen Stegeman 22 Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Gary S. Hoffman, Carol A. Langford and Ulrich Specks 23 Churg–Strauss Syndrome (Eosinophilic Granulomatosis with Polyangiitis, EGPA) Christian Pagnoux and Loïc Guillevin 24 Giant cell arteritis Cornelia M. Weyand and Jörg J. Goronzy 25 Takayasu's arteritis Kathleen Maksimowicz-McKinnon and Gary S. Hoffman 26 Behçet's Syndrome Yusuf Yazici, Ismail Simsek and Hasan Yazici 27 Cogan's Syndrome Rex M. McCallum and E. William St. Clair 28 Idiopathic cryoglobulinemic vasculitides Benjamin Terrier and Patrice Cacoub 29 Primary central nervous system vasculitis Rula A. Hajj-Ali and Leonard H. Calabrese 30 Single organ vasculitis José Hernández-Rodríguez and Gary S. Hoffman 31 Primary cutaneous vasculitis Jeffrey P. Callen 32 Buerger's disease (thromboangiitis obliterans) Ahmet Ruchan Akar and M. Serkan Durdu Section III. Secondary Causes of Vasculitis 33 Virus-associated vasculitides Dimitrios Vassilopoulos and Leonard H. Calabrese 34 Drug-induced vasculitis Peter A. Merkel 35 Rheumatoid vasculitis Kimberly P. Liang, Carl Turesson, Larry W. Moreland 36 Vasculopathy/Vasculitis and progressive systemic sclerosis Nezam Altorok, Omar R. Kahaly and Bashar Kahaleh 37 Vasculitis and Sjögren's syndrome George E. Fragoulis and Haralampos M. Moutsopoulos 38 Vasculitis in systemic lupus erythematosus Ricardo Garcia and Andras Perl 39 Vasculitis in the Idiopathic Inflammatory Myopathies Frederick W. Miller and Chester V. Oddis 40 Vasculitis and relapsing polychondritis Tanaz A. Kermani and Kenneth J. Warrington 41 Systemic Vasculitis in Sarcoidosis Alexandra Villa-Forte and Gary S. Hoffman 42 Vasculitis as a Paraneoplastic Syndrome and Direct Tumour Invasion of Vessels Claire E. Barber and Simon Carette Section IV. Recognizing Risks and Treating Damage from Vasculitis 43 Cholesterol and Modifications of Cholesterol in Rheumatic Disorders Jan Willem Cohen Tervaert 44 Prevention and treatment of medical complications Atul Khasnis and Carol A. Langford 45 Ophthalmic Risks and Complications Aassociated with the Treatment of Systemic Vasculitis Steven Yeh and James T. Rosenbaum 46 Subglottic Stenosis of Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Rahul Seth and Daniel S. Alam 47 Sino-Nasal Manifestations of Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Daniel S. Alam, Rahul Seth, Raj Sindwani 48 Neurologic Damage of Vasculitis C. David Lin 49 Endstage Renal Disease and Vasculitis Kirsten de Groot and Charles Pusey 50 Cardiothoracic Surgery for Takayasu's Arteritis and Giant Cell Arteritis Turki Albacker and Lars Svensson 51 Peripheral Vascular Surgery for Takayasu's Arteritis and Giant Cell Arteritis Ravi R. Rajani and Vikram S. Kashyap Index

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Book SynopsisTrade Review"This is a comprehensive, accurate, and up-to-date publication on the major issues in pediatric hematology/oncology. Both the book and the website are outstanding resources for any of the intended users -- students, practitioners, clinical and research investigators." ~Joseph Rosenthal, MD, City of Hope Doody Score: 4 stars "This is an extremely useful, indispensable print and online resource on diseases of infants and children relating to the blood and cancer. It is a massive reference source that is well-researched, expertly organized and thoughtfully written." ~Nano KhilnaniTable of ContentsSection I Neonatal Hematology 1. Anatomy and Physiology of Hematopoiesis 2. The Neonatal Erythrocyte and Its Disorders 3. Immune Hemolytic Disease 4. Neonatal Jaundice and Disorders of Bilirubin Metabolism 5. Hemostasis in the Newborn and Infant Section II Bone Marrow Failure 6. Acquired Aplastic Anemia and Pure Red Cell Aplasia 7. Inherited Bone Marrow Failure Syndromes 8. Principles of Bone Marrow and Stem Cell Transplantation Section III Disorders of Erythrocyte Production 9. Diagnostic Approach to the Anemic Patient 10. Megaloblastic Anemia 11. Disorders of Iron and Copper Metabolism, Sideroblastic Anemias and Lead Toxicity 12. Porphyrias Section IV Hemolytic Anemias 13. Autoimmune Hemolytic Anemia 14. Paroxysmal Nocturnal Hemoglobinuria 15. Red Cell Membrane 16. Disorders of the Red Cell Membrane 17. Pyruvate Kinase Deficiency and Disorders of Glycolysis 18. Glucose-6-Phosphate Dehydrogenase Deficiency 19. Normal and Abnormal Hemoglobins Section V Disorders of Hemoglobin 20. Sickle Cell Disease 21. Thalassemias Section VI Phagocyte System 22. Phagocyte System and Disorders of Granulopoiesis and Granulocyte Function Section VII Immune System 23. Immune Response 24. Primary Immunodeficiency Diseases Section VIII Storage Diseases 25. Lysosomal Storage Diseases Section IX Hemostasis 26. Platelets and the Vessel Wall 27. Blood Coagulation 28. Molecular Basis of Fibrinolysis 29. Approach to the Child with a Suspected Bleeding Disorder 30. Inherited Platelet Disorders 31. Hemophilia and von Willebrand Disease 32. Rare Hereditary Coagulation Factor Abnormalities 33. Inherited Disorders of Thrombosis and Fibrinolysis 34. Acquired Platelet Defects 35. Acquired Disorders of Hemostasis Section X Supportive Therapy 36. Transfusion Medicine Section XI Hematologic Manifestations of Systemic Diseases 37. Hematological Manifestations of Systemic Diseases 38. Hematology Manifestations of Systemic Diseases in Children of the Developing World Section XII Biology of Cancer 39. Origins and Evolution of Pediatric Cancer 40. Epidemiology of Leukemia in Childhood 41. Informatics 42. Genetic Predisposition to Cancer 43. Genetic and Epigenetics of Childhood Cancers 44. Targeted Therapies in Oncology 45. Cytogenetic and Molecular Pathology of Pediatric Cancer Section XIII Pediatric Cancer Therapeutics 46. Cancer Chemotherapy for Pediatric Patients 47. Immunotherapy of Cancer 48. Pediatric Radiation Oncology 48. Pediatric Surgical Oncology Section XIV Hematologic Malignancy 50. Acute Lymphoblastic Leukemia 51. Pediatric Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease 52. Infant Leukemias 53. Pediatric Lymphoma Section XV Solid Tumors 54. Neuroblastoma 55. Pediatric Renal Tumors 56. Retinoblastoma 57. Tumors of the Brain and Spinal Cord 58. Hepatoblastoma and Other Liver Tumors in Children 59. Rhabdomyosarcoma 60. Nonrhabdomyosarcoma Soft Tissue Sarcomas and Other Soft Tissue Tumors 61. Ewing Sarcoma 62. Osteosarcoma 63. Pediatric Germ Cell Tumors 64. Histiocytoses 65. Rare Tumors of Childhood 66. Imaging in the Evaluation and Management of Childhood Cancer Section XVI Supportive Care 67. Infectious Disease in the Pediatric Cancer Patient 68. Oncologic Emergencies 69. Nursing Care of Patients with Childhood Cancer 70. Palliative Care in Pediatric Oncology 71. Symptom Management in Children with Cancer 72. Childhood Cancer Survivorship 73. Psychosocial Care of the Child and Family 74. Ethical Considerations in Pediatric Oncology Clinical Trials Appendices: Reference Values in Infancy and Childhood

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Book SynopsisIn this ground-breaking account of the political economy and cultural meaning of blood in contemporary India, Jacob Copeman and Dwaipayan Banerjee examine how the giving and receiving of blood has shaped social and political life. Hematologies traces how the substance congeals political ideologies, biomedical rationalities, and activist practices.Using examples from anti-colonial appeals to blood sacrifice as a political philosophy to contemporary portraits of political leaders drawn with blood, from the use of the substance by Bhopali children as a material of activism to biomedical anxieties and aporias about the excess and lack of donation, Hematologies broaches how political life in India has been shaped through the use of blood and through contestations about blood. As such, the authors offer new entryways into thinking about politics and economy through a bloodscape of difference: different sovereignties; different proportionalities; and different temporalTrade Review"This book is unparalleled in its ability to show how the political absorbs the techno-scientific over various scales and temporalities in contemporary India. The authors take breath-taking risks with the plethora of objects and contexts they dwell on but manage to land on the ground each time. A splendid achievement." -- Veena Das, Johns Hopkins University"This book is an extraordinary exploration of the multitudes of meanings and uses of blood in northern India. Its breadth and range make the questions it raises of wide interest, from blood as a donation, as a means to political protest, as a sign of modernity or patriotism" -- Emily Martin, New York University"This revelatory book brings us a thoroughly political hematology, not only tracking economies of sacrifice, extraction, and spillage, but also thinking through blood as a medium for writing, for protest, and for the telling of historical time" -- Stefan Helmreich, MIT"Hematologies is an astute, learned, and ground-breaking account of the political economy and cultural meaning of blood in contemporary India, the product of a powerful, cogent collaboration between two prominent and exciting thinkers." -- Rachel Berger, Concordia University, author of Ayurveda Made Modern"Jacob Copeman and Dwaipayan Banerjee have written a deeply insightful book on the potent symbolism and political significance of blood." -- Joseph Alter, University of Pittsburgh, author of Gandhi's BodyTable of ContentsAcknowledgments 1. Bloodscape of Difference 2. Sovereignty and Blood 3. Substantial Activisms 4. Hemo Economicus: From Blood Sacrifice to Blood Science? 5. The Broken World of Transfusion 6. Blood in the Time of the Civic 7. Hematic Futures Notes References Index

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Book SynopsisIn this ground-breaking account of the political economy and cultural meaning of blood in contemporary India, Jacob Copeman and Dwaipayan Banerjee examine how the giving and receiving of blood has shaped social and political life. Hematologies traces how the substance congeals political ideologies, biomedical rationalities, and activist practices.Using examples from anti-colonial appeals to blood sacrifice as a political philosophy to contemporary portraits of political leaders drawn with blood, from the use of the substance by Bhopali children as a material of activism to biomedical anxieties and aporias about the excess and lack of donation, Hematologies broaches how political life in India has been shaped through the use of blood and through contestations about blood. As such, the authors offer new entryways into thinking about politics and economy through a bloodscape of difference: different sovereignties; different proportionalities; and different temporalTable of ContentsAcknowledgments 1. Bloodscape of Difference 2. Sovereignty and Blood 3. Substantial Activisms 4. Hemo Economicus: From Blood Sacrifice to Blood Science? 5. The Broken World of Transfusion 6. Blood in the Time of the Civic 7. Hematic Futures Notes References Index

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Book SynopsisThis book introduces the advanced topics regarding renal failure including manifold findings of physiologic, pathophysiologic and clinical aspects in the kidney. The kidney plays a crucial physiologic role in the regulation of urinary formation, fluid balance, nutrition metabolism, blood pressure and other aspects in the living body. Renal failure is a condition of a decline or loss of kidney function due to deficiency of functioning nephrons. Acute renal failure is a syndrome, which is characterized by acute decline or loss of kidney function due to temporary disfunctioning or blocking of nephrons. Acute renal failure is a reversible condition and is a secondary manifestation, a complication of another underlying critical illness. Chronic renal failure is a condition of slow, gradual decline of kidney function due to irreversible destruction of nephrons. This book provides recent information concerning acute and chronic renal failure in clinical aspects, and is constituted in five chapters.

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Book SynopsisCyclic AMP was a major molecule of interest, which played an important role as second messenger, contributing to signal transduction in the regulation of cellular function by peptide hormones. Afterwards, calmodulin and protein kinase C were discovered as modulator proteins of intracellular calcium signaling in hormonal action. After that, manifold proteins and their related molecules were demonstrated to participate in novel signaling pathways related to various cytokines in different types of cells. The author of this book discovered a novel protein known as regucalcin, which suppresses manifold signaling pathways related to transcription activity. After subsequent studies, regucalcin has been established to play a pivotal role in maintaining cell homeostasis and protecting it from disorders in various types of cells and tissues. This book will provide information regarding regucalcin that plays a pivotal role in cell homeostasis and disorder. This book is composed of eighteen chapters. These chapters include the following content: the discovery of regucalcin (Chapter One); chemical property and structure of regucalcin (Chapter Two); the regucalcin gene and its translational regulation (Chapter Three); the role of regucalcin in intracellular calcium homeostasis (Chapter Four); the role of regucalcin in cell nuclear function (Chapter Five); the role of regucalcin in protein synthesis and proteolysis (Chapter Six); the suppressive role of regucalcin in cell proliferation (Chapter Seven); how regucalcin protects apoptotic cell death (Chapter Eight); the protective role of regucalcin in oxidative stress (Chapter Nine); the involvement of regucalcin in liver metabolic disorder (Chapter Ten); the role of regucalcin in kidney cell homeostasis: involvement in renal failure (Chapter Eleven); the role of regucalcin in heart calcium signaling: insight into cardiac disorder (Chapter Twelve); the role of regucalcin in brain calcium homeostasis: disorder with aging (Chapter Thirteen); the role of regucalcin in bone homeostasis and osteoporosis (Chapter Fourteen); the role of regucalcin in lipid metabolism and diabetes (Chapter Fifteen); the role of regucalcin as a suppressor protein in carcinogenesis (Chapter Sixteen); the clinical aspects of regucalcin as a biomarker for disease (Chapter Seventeen); and conclusive remarks (Chapter Eighteen). This book will provide information regarding regucalcin and its pivotal role in cell homeostasis and disorder.

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Book SynopsisPrevailing physiological concepts (PPC) of blood circulation consider the cardiovascular system (CVS) an autonomous system that has its own goal and mechanisms for achieving it. Physiologists agreed that complex neural and humoral controllers of a mean arterial pressure (MAP) indirectly alter the blood flows for satisfying cellular needs. However, PPCs are incapable of explaining the causes of long-term shifts of an MAPs rest level. In particular, this affects current understanding and cure technologies of arterial hypertension (AH). Considering AH as a disease, physicians seek a cure that effectively decreases the elevated pressure. This gave rise to the palliative cure softening of AH symptoms without an understanding of AHs primary causes. But this strategy, working until the patient intakes antihypertensive drugs, often leads to AHs further development, and in extreme cases current antihypertensive drugs are helpless. These limitations of PPC are forced to seek a circulations extended physiological theory (EPT), explaining the mechanisms of both normal and altered MAPs. In the EPT presented in the book, CVS is considered a constituent part of a more complex functional super-system (FSS) that appeared in a multi-cellular animal organism during the co-evolution of specialized cells. The general goal of the FSS is to provide optimal physiochemical and energy states of the cell cytoplasm. To achieve this goal under a stochastic total and local variations of cells activity, FSS should control: i) The cardiac output; ii) the regional and local blood flows; and iii) the chemical composition of both arterial and venous blood. Under chronic energy shortage, FSS should also provide an adequate increasing of ATP-synthesis in mitochondria of stagnated cells. So, under the ineffectiveness of current mitochondria, FSS must enrich the arterial blood by chemicals providing the biogenesis of mitochondria. However, neither the energy providers nor the providers of blood chemistry are properly involved in PC of the blood circulation. The EPT for the first time integrates the hemodynamic and metabolic aspects of cell life at the organism scale. It is proved that the CVS activity is inversely associated with the activity mechanisms controlling the rates of both pulmonary ventilation and erythropoiesis. Under significant and chronic energy deficiency, the cells activate additional FSS mechanisms, materially supporting the biogenesis of mitochondria. The activity of FSS mechanisms forming the chemical composition of arterial and venous blood is in reciprocal relationships with the function of CVS. So, the EPT associates the function of CVS with energy and metabolic problems in cells. The EPT concerns both traditional and additional determinants of the MAP level. It is proved that stochastic combinations of these determinants force the MAP level to float. In particular, both the mitochondrial insufficiency and the chemical contamination of cytoplasm are capable of causing AH. The normal arterial pressure is always individual. Before correcting the altered arterial pressure, a complex medical examination for ascertaining the mitochondrial function, the status of the FSS mechanisms is recommended. The diagnosis of AH should be reoriented for detecting cellular abnormalities. The therapy of AH should be targeted at finding strategies for the optimizing the entire FSS function.

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Book SynopsisNatural killer (NK) cells are important effector cells of innate immune system implicated in many physiological processes including elimination of cancer cells and virus infected cells. NK cells comprise a majority of large granular lymphocytes circulating in peripheral blood with a minority derived from T cell lineage. Even though NK cells were first described more than 40 years ago, it was not until the 1980s and 1990s when immunophenotyping was incorporated into clinical diagnostic methods and resulted in discovery of distinct disorders of large granular lymphocytes and NK cells. Since then, significant progress was made in our better understanding of immunophenotypic and genotypic characteristics, biology, functions as well as disorders of these cells. Most recently, clinical studies using NK-cell based immunotherapy have shown promising results in treatment of some of malignant diseases. Disorders of large granular lymphocytes and NK cells are rare comprising only about 1% of all lymphoid malignancies in western countries. The rarity of these conditions was a main reason that the progress in our understanding of pathogenesis and development of novel therapeutic approaches has been delayed compared to development in more common B cell lymphoid malignancies. The low incidence of these diseases and scarcity of prospective clinical trials also limit the availability of evidence based research literature as well as comprehensive reviews about NK cell disorders. Thus, the editors decided to take on the challenging task and summarize our current knowledge about malignant and benign diseases of large granular lymphocytes in this book based on the best available evidence. The editors selected topics most relevant to clinical practice in order to provide a useful guide for practicing physicians. Chapters describing four disorders (T-cell large granular lymphocytic leukemia, chronic lymphoproliferative disorder of NK cells, extranodal NK cell lymphoma and aggressive NK cell leukemia) incorporated into most recent 2016 revision of classification of lymphoid malignancies are separated into experimental, diagnositc and clinical parts for easier understanding and reading. We are aware of challenges and inherited limitations of any larger project like this one due to a rapid progress especially in the field of genomics, which may not be incorporated in this book before it is published. The editors and contributing authors would like to thank the publisher NOVA for their support.

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Book SynopsisThe opening chapter of this compilation is dedicated to the quantification of selenium and platinum in blood serum by electrothermal atomic absorption spectrometry. While selenium is an essential trace element in many selenoproteins, platinum is found in the human body as a consequence of chemotherapy treatment after the administration of Pt-based drugs. For these reasons, their reliable quantification is extremely important. The authors go on to discuss how the early diagnosis of neurodegenerative diseases is important for more efficient treatment and prophylaxis. Currently, the dominant hypothesis of the pathogenesis of Alzheimer's disease is amyloid cascade resulting in accumulation of amyloid-β in brain structures. In conclusion, the authors discuss the major barrier to a widespread use of blood serum eye drops represented by the lack of standardized processes for the preparation, conservation, and dispensation of the products. Future perspectives of homologous serum eye drops include the introduction of tailored eye drops screened for the desired content of growth factors for each patient and ocular surface disease.Table of ContentsFor more information, please visit our website at:https://novapublishers.com/shop/a-closer-look-at-blood-serum/

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Book SynopsisThe authors summarise advances in human pluripotent stem cells-derived erythroid development and molecular regulatory mechanisms. This research may provide a new perspective on human embryo erythropoiesis and a possible treatment for some hematological diseases. Erythrocytes are well equipped to carry out their functions due to a dynamic cell membrane, their inherent shape and lack of organelles and cytoplasmic viscosity. As such, the following section focusses on the causes of these modifications and their clinical implications. As an example of complexity in research towards the development of erythrocyte membrane-based drug delivery systems starting from animal erythrocyte, morphological, biochemical and drug release profiles will be reviewed in the penultimate chapter. The final chapter investigates the electrochemical behavior of erythrocytes at platinum, carbonaceous, and optically transparent electrodes via polarization and coulometric measurements. The order of magnitude of the quantity of electrons transferred between erythrocytes and electrodes was determined, and potential ranges showing indifference of the electrode toward red blood cells were identified.

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Book SynopsisHemostasis involves a set of strictly regulated processes that maintain blood in its fluid state within the vascular bed and, in case of vessel injury, promote the formation of platelet plugs and fibrin clots to prevent blood extravasation. As such, Platelets: Overview, Function and Disorders explores how platelets play an important role in the blood coagulation process, and how platelet deficiencies or functional defects may be the cause of some bleeding disorders. The worldwide incidence of cutaneous melanoma has been increasing annually at a more rapid rate in comparison to any other type of cancer affecting predominantly young and middle-aged individuals. It is known that when melanoma cells leave the primary tumor and enter the blood stream, they activate surrounding platelets via some molecules, inducing microthrombus formation. The authors discuss how platelets contribute to inflammation, cancer invasion, and metastasis. Additionally, the role of platelet-rich-plasma in stimulating the healing process in difficult-to-heal ulcers has been investigated over the past 25 years. It is suggested that platelet-rich-plasma is capable of transforming the difficult-to-heal skin ulcer with low metabolic activity into a healing ulcer with increased capacity for tissue regeneration. This closing study focuses on the causes, diagnosis, and prognosis of various types of thrombocytopenia, providing an outline on the future prospects of using antioxidants for the treatment of a few thrombocytopenic conditions.

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Book SynopsisIntricate processes involved in perpetuating the multitude of physiological phenomena in the human body often encounter aberrations and omissions in the genetic code of life. While such errors often lead to lethal diseases, at other times they provide distinctive survival advantages and thus unscramble cues to unconventional therapeutic strategies for life-threatening conditions. Hereditary Persistence of Fetal Hemoglobin (HPFH) is one such condition wherein the typically inactivated fetal form of hemoglobin (HbF) remains overexpressed even in adult stages of the bearer's life. Strikingly, this condition is known to ameliorate pathological manifestations in patients with aberrant adult hemoglobin synthesis (e.g. β-hemoglobinopathies like β-thalassemia, sickle cell disease etc.). Early researchers in the field expected such patients to suffer from clinical challenges owing to HbF's high affinity to oxygen and consequent difficulty in its release to cells and tissues. Surprisingly, these patients are known to lead a physiologically normal life. Modern-day hematologists and clinical researchers have looked-up to the concept of "HbF reactivation" as a potential curative strategy for patients suffering from β-hemoglobinopathies like β-thalassemia and sickle cell disease. As a result, several drugs like hydroxyurea, 5-azacytidine, cytosine arabinoside, natural products etc. have been tried in clinics to elevate HbF levels in such patients with limited success and poor understanding on the mechanisms of their action. Associated side-effects and complications of using cytotoxic agents like these restrict their use in most instances. Fortunately, with the advent of newer molecular tools and techniques, researchers are focusing their attention to reengineer the molecular machinery and thus reactivate the gamma-globin gene. This book brings together a selection of chapters dedicated to fetal hemoglobin -- its physiological role, regulation, methodologies to manipulate and future strategies. Researchers and scientists interested in the topic will have a comprehensive understanding of the current concepts on fetal hemoglobin modulation and therefore will serve as a launching pad for their research ideas.Table of ContentsDedication; Preface; Acknowledgements; Hemoglobin: A Biochemical and Molecular Overview; Prenatal and Postnatal Hemoglobins: Formation and Gaseous Exchange; An Introduction to Fetal Hemoglobin and Its Characteristics; Regulation of the Gamma Globin Gene: Current Concepts and Perspectives; Role of Cell Signaling Pathways in Fetal Hemoglobin Regulation in Beta-Hemoglobinopathies; Molecular Tools for Editing Globin Genes; Genetic Modifiers of Fetal Hemoglobin and Their Role in Alleviating the Clinical Severity of Hemoglobinopathies; Therapeutic Induction of Fetal Hemoglobin Expression: Methods in Practice and Newer Modalities; Genetic Modifiers of β-Thalassemia and Their Therapeutic Implications; Clinical Management of β-thalassemia; Current Practices in the Management of Beta-Hemoglobinopathies; About the Editor; Index.

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Book SynopsisIn this compilation, the authors review the biological aspects of myelodysplastic syndrome disease, diagnosis, and treatment, as well as innovations involving genetics and new treatment perspectives. Myelodysplastic syndromes are a heterogeneous group of clonal haematopoietic stem cells disorders characterized by dysplasia, as well as peripheral blood cytopenias with a hypercellular marrow and ineffective hematopoiesis. Myelodysplastic syndromes are frequently associated with acute and chronic inflammation, and autoimmune disorders such as: rheumatoid arthritis, bowel disease, diverse types of vasculitis, autoimmune anemias, several rheumatic and skin disorders, and certain thyroid disorders. Spliceosome mutations are the most frequent mutations found in blood and bone marrow cells of myelodysplastic syndromes patients. As such, the authors explore the four predominant splicing factor genes: SF3B1, SFRS2, U2AF1, ZRSR2. Subsequently, this collection discusses the CSNK1A1 gene in the context of myelodysplastic syndromes. It is located at 5q32 within the deleted region, which encodes for casein kinase 1α (CK1α). CK1α is a component of a multiprotein β-catenin destruction complex that regulates Wnt/β-catenin and p53 pathways. The concluding study focuses on the mutations in epigenetic modifiers occur which myelodysplastic syndromes and drive this disease, such as: DNA methylation, histone acetylation, and RNA interference that alters gene expression.Table of ContentsPreface; Myelodysplastic Syndrome: An Overview; An Updated Approach to Myelodysplastic Syndromes (MDS); The Inflammatory and Autoimmune Dysregulation in Myelodysplastic Syndromes; Spliceosome Mutations and Alternative Splicing of Pre-Messenger RNA in Myelodysplastic Syndromes; Myelodysplastic Syndrome with Chromosome 5q: Deletion and Its Treatment; Epigenetic Mechanisms and Therapy of Myelodysplastic Syndromes; Index.

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Book SynopsisIneffective haematopoiesis in bone marrow and peripheral cytopenias are features of bone marrow failure and related syndromes. These diseases can progress to myelodysplastic syndrome, acute myeloid leukaemia, and other malignancies. Acute myeloid leukaemia is a heterogeneous complex malignancy characterized by proliferating myeloblasts in the bone marrow and a diverse range of recurrent molecular aberrations that occur in many different combinations. More specifically, the authors explore the McDonough strain of feline sarcoma virus-related tyrosine kinase 3 receptor mutations present in about 30-35% of acute myeloid leukaemia patients. The way in which the Wnt signalling pathway plays an important role in normal haematopoiesis and its deregulation associated with acute myeloid leukaemia is also discussed. This compilation also explores the importance of residual leukemic cells in disease relapse prognosis, as the new definition of the European LeukemiaNet for complete remission includes minimal or measurable residual disease negativity. Mutations detected in patients with clonal haematopoiesis are addressed, including those which most commonly affect DNMT3A, ASXL1, TET2, JAK2, SF3B1, SRSF2, and TP53 genes that had previously been identified as drivers in various myeloid neoplasms. The authors provide an overview of the roles of extracellular vesicles in multiple myeloma, their capacity as emerging biomarkers, and implications for liquid biopsy for detection and monitoring. The penultimate study focuses on toll-like receptors, which play an essential role in the recognition of invading pathogens via specific microbial molecular motifs, forming a bridge between the innate and adaptive immune responses. In conclusion, this compilation explores PROTACs, proteolysis targeting chimeras, which mediate the degradation of proteins of interest by hijacking the activity of E3-ubiquitin ligases for POI polyubiquitination and subsequent degradation by proteasome.Table of ContentsPreface; Inherited Bone Marrow Failure and Genetic Predisposition to Myelodysplastic Syndrome and Acute Myeloid Leukemia; The Phosphatidylinositol 3-Kinase (PI3K) Pathway in Acute Myeloid Leukemia and Inhibition of Mechanistic Target of Rapamycin (mTOR) as a Therapeutic Target; Targeting Oncogenic Signaling in Mutant FLT3 Acute Myeloid Leukemia by FLT3 Tyrosine Kinase Inhibitors; Aberrant Wnt / β-Catenin Signaling Pathway in Acute Myeloid Leukemia; Minimal or Measurable Residual Disease Detection in Acute Myeloid Leukemia; Clonal Hematopoiesis as a Precursor of Myeloid Cancers; Understanding the Role of Extracellular Vesicles in Multiple Myeloma; Toll-Like Receptors Signaling Pathways in Hematologic Malignancies; Targeted Protein Degradation Using Proteolysis Targeting Chimeras (PROTACs) in Hematologic Malignancies; Index.

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Book SynopsisA Guide to Paediatric Red Blood Cell Disorders is a comprehensive text on common red blood cell disorders encountered in children. It is a useful guide to postgraduate doctors training in paediatrics and haematology, medical undergraduates, primary care physicians and practising clinicians. The book is divided into five sections. The first section provides a detailed understanding of the basic concepts and approach to red blood cell disorders in children. This section includes information on the structure and function of red blood cells and haemoglobin, epidemiology and aetiology of anaemia and clinical and laboratory evaluation of childhood anaemia. The next three sections will provide information on paediatric conditions that result in microcytic, normocytic and macrocytic anaemia, respectively. The final section will be on conditions leading to polycythaemia in neonates and children. Throughout the book, the emphasis is given to common conditions that are frequently encountered in clinical practice. However, rare but clinically important conditions have also been included. Each chapter is divided into subheadings to describe the epidemiology, aetiology, genetic basis, molecular pathology, pathophysiology, classification, clinical features, investigations, diagnosis, treatment, follow-up and prognosis of each disorder. At the end of each chapter, a section on recent advances provides information on promising novel developments and experimental approaches for treating these diseases. This book will help medical undergraduates to grasp concepts and understand the entire spectrum of red blood cell disorders in children. For practising clinicians, this will be a useful guide on how to approach a child with anaemia, which is one of the most common presentations to general practice, field clinics and hospitals. For postgraduate doctors training in paediatrics and haematology, the book will provide comprehensive information on how to manage common as well as complex red blood cell disorders in children. This book is concise, reader-friendly and written in simple English, which can be understood by non-native speakers. It will aid readers across the globe to grasp the concepts of paediatric red blood cell disorders easily and be knowledgeable and up to date in managing these patients.Table of ContentsPreface; Part 1: Basic Concepts and an Approach to Red Blood Cell Disorders; Red Blood Cells and Haemoglobin; Evaluation of Childhood Anaemia. Part 2: Microcytic Anaemias -- Iron Deficiency Anaemia; Thalassaemia; Sickle Cell Disease; Other Microcytic Anaemias. Part 3: Normocytic Anaemias -- Hereditary Spherocytosis and Other Membranopathies; Glucose 6-Phosphate Dehydrogenase Deficiency and Other Enzymopathies; Autoimmune Haemolytic Anaemias; Microangiopathic Haemolytic Anaemias; Neonatal Anaemias; Other Normocytic Anaemias. Part 4: Macrocytic Anaemias -- Megaloblastic Anaemia; Red Blood Cell Aplasia; Other Macrocytic Anaemias. Part 5: Polycythaemia -- Neonatal Polycythaemia; Childhood Polycythaemia; Index.

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Book SynopsisHaematological malignancies, defined as cancers that affect the blood, bone marrow, and lymph nodes, represent a serious health care challenge for oncologists. Chapter One focuses on cytogenetic and molecular markers and summarizes their importance in identification, treatment and prognosis in patients with myeloproliferative neoplasms. Chapter Two details the efficacy of treatment of myeloid hematologic malignancies with isocitrate dehydrogenase mutations by inhibitors of this enzyme. Chapter Three describes the use of Selinexor and other drugs for the treatment of hematologic malignancies. Chapter Four explains the utility of poly(ADP-ribose) polymerase inhibitors in the treatment of myelodysplastic syndrome and acute myeloid leukaemia.Table of ContentsPreface; Molecular and Cytogenetic Markers and Their Clinical Implications in Myeloproliferative Neoplasms; Treatment of Myeloid Hematologic Malignancies with Isocitrate Dehydrogenase Mutations by Inhibitors of This Enzyme; Inhibition of Nuclear Export as a New Therapy in Hematologic Malignancies; Poly(adp-Ribose) Polymerase Inhibitors in the Treatment of Myelodysplastic Syndrome and Acute Myeloid Leukemia; Index.

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Book SynopsisSickle cell anaemia is an inherited blood disorder, characterised primarily by chronic anaemia and periodic episodes of pain and occurring in approximately 1 in every 400 African-American infants born in the United States each year. Individuals of Mediterranean, Arabian, Caribbean, South and Central American, and East Indian ancestry can also be affected. The underlying problem involves haemoglobin, a component of the red cells in the blood. The haemoglobin molecules in each red blood cell carry oxygen from the lungs to the body organs and tissues and bring back carbon dioxide to the lungs. In sickle cell anaemia, the haemoglobin is defective. After the haemoglobin molecules give up their oxygen, some of them may cluster together and form long, rod-like structures. These structures cause the red blood cells to become stiff and to assume a sickle shape. Unlike normal red cells, which are usually smooth and donut-shaped, the sickled red cells cannot squeeze through small blood vessels. Instead, they stack up and cause blockages that deprive the organs and tissue of oxygen-carrying blood. This process produces the periodic episodes of pain and ultimately can damage the tissues and vital organs and lead to other serious medical problems. Unlike normal red blood cells, which last about 120 days in the bloodstream, sickled red cells die after only about 10 to 20 days. Because they cannot be replaced fast enough, the blood is chronically short of red blood cells, a condition called anaemia. Sickle cell anaemia is caused by an error in the gene that tells the body how to make haemoglobin. The defective gene tells the body to make the abnormal haemoglobin that results in deformed red blood cells. This book gathers the latest research in this important field.

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Book SynopsisAngiogenesis -- the growth of new blood vessels -- is an important natural process occurring in the body, both for health and as related to disease. Angiogenesis occurs in the healthy body to help heal wounds and to help restore blood flow to tissues after injury or insult. In females, Angiogenesis also occurs during the monthly reproductive cycle (to rebuild the uterus lining, to mature the egg during ovulation) and during pregnancy (to build the placenta, the circulation between mother and foetus). The healthy body controls Angiogenesis through a series of ''on'' and ''off'' switches. The main ''on'' switches are known as Angiogenesis-stimulating growth factors. The main ''off'' switches are known as Angiogenesis inhibitors. When angiogenic growth factors are produced in excess of angiogenesis inhibitors the balance is tipped in favour of blood vessel growth. When inhibitors are present in excess of stimulators, angiogenesis is stopped. The normal, healthy body maintains a perfect balance of angiogenesis modulators. In general, angiogenesis is ''turned off'' by the production of more inhibitors than stimulators. Tumour angiogenesis is the proliferation of a network of blood vessels that penetrates into cancerous growths, supplying nutrients and oxygen and removing waste products. Tumour angiogenesis actually starts with cancerous tumour cells releasing molecules that send signals to surrounding normal host tissue. This signalling activates certain genes in the host tissue that, in turn, cause proteins to encourage growth of new blood vessels. This new book examines its angiogenesis within the context of theory and its applications to cancer treatment.

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Book SynopsisAnaemia is the common health problem all over the world. The term "tropical anaemia" means the anaemic disorders, which are predominant in the tropical region of the world. The purpose of this book is to summarise and present the topics specifically relating to the anaemia in the forms that is unique in the tropical countries. Due to the globalisation in the present day, the change in the epidemiology of diseases from one site to the others all around the world can be expected. The summative on the common anaemic problems in the tropical countries can be and should be performed. This book can make them at least realise the problems. The details of this book focus on the anaemia in the aspects relating to the tropical medicine. The book covers specifically the clinical aspects, scientific laboratory aspects, public health aspects as well as the social sciences relating to anaemia in important tropical diseases. The common tropical diseases, including inherited disorders and infectious diseases, which relate to the anaemia are summarised, presented and discussed. Mainly the book presents summative data from the molecular to the population scales, as well as additional metanalysis for important topics. In addition, the diagnostic guideline and clinical practice guideline of the mentioned conditions are presented.

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