Description

Book Synopsis
A vital resource on blood and bone marrow cell morphology in laboratory animal medicine. This fully revised new edition is an essential reference for clinical pathologists in diagnostic laboratories, and medical or veterinary research. The atlas contains over 400 color images of cells from the peripheral blood and bone marrow from a variety of animals encountered in laboratory animal medicine, in health and disease.

Key features:

  • New chapter on flow cytometry and its application in terms of routine analyses as a means of identifying abnormalities in cell marker expression, which is of particular relevance for pre-clinical safety assessment
  • Covers the most recent developments in laboratory animal hematology, including parameters measured by the latest generation of analyzers
  • Coverage of a wide range of laboratory animal species, as well as those used in clinical veterinary trials
  • Photomicrographs present normal and abnormal blood cells from a

    Trade Review

    “This book may not be useful for the typical veterinary student or practitioner, but it is an excellent resource for those involved in preclinical studies on toxicosis.” (Journal of The American Veterinary Medical Association, 15 June 2012)

    "A fine college reference!." (The Midwest Book Review, 1 November 2011)

    Table of Contents

    Foreword vii

    Introduction ix

    Dedication xi

    Acknowledgments xiii

    1 Rodents 1

    Mouse 1

    Introduction 1

    Blood picture 1

    Typical ranges (Siemens Advia 120) 2

    Hamster 15

    Introduction 15

    Blood picture 15

    Guinea Pig 17

    Introduction 17

    Blood picture 17

    Rat – Sprague Dawley (SD)/Han Wistar (HW) 18

    Introduction 18

    Blood picture 18

    Typical ranges (Siemens Advia 120) 19

    References 36

    2 Rabbit 37

    Introduction 37

    Blood picture 37

    References 39

    4 Dog 45

    Introduction 45

    Blood picture 45

    Typical ranges (Siemens Advia 120) 46

    References 64

    5 Monkey 65

    Introduction 65

    Blood picture 65

    Marmoset 66

    Cynomolgus 71

    Introduction 71

    Blood picture 71

    Typical ranges (Siemens Advia 120) 72

    Baboon 84

    Rhesus Monkey 86

    References 87

    6 Other species 89

    Pig 89

    Introduction 89

    Blood picture 89

    Horse 91

    Introduction 91

    Blood picture 91

    Goat and Sheep 94

    Assorted Other Species 96

    References 103

    3 Cat 41

    Introduction 41

    Blood picture 41

    References 44

    7 Blood collection procedures 105

    Common bleeding sites 105

    Anticoagulants 105

    Staining 105

    8 Artifacts 107

    Collection artifacts 107

    Sample transport and storage 109

    Anticoagulant 110

    Storage artifacts 111

    Blood smear preparation 113

    Stain precipitate 113

    References 114

    9 Bone marrow 115

    Introduction 115

    Review of marrow sampling techniques 115

    Recommended methods for marrow sampling 116

    Preparation and staining of smears 118

    Evaluation 119

    Interpretation 119

    References 120

    10 Comparative applications in flow cytometry 121

    Application of flow cytometry in comparative hematology 122

    References 132

    Index 135

Atlas of Comparative Diagnostic and Experimental

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    A Hardback by Clifford Smith, Alfred Jarecki

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      Trusted by thousands of customers. See 2,385+ Customer Reviews

      View other formats and editions of Atlas of Comparative Diagnostic and Experimental by Clifford Smith

      Publisher: John Wiley and Sons Ltd
      Publication Date: 15/07/2011
      ISBN13: 9781405171076, 978-1405171076
      ISBN10: 1405171073

      Description

      Book Synopsis
      A vital resource on blood and bone marrow cell morphology in laboratory animal medicine. This fully revised new edition is an essential reference for clinical pathologists in diagnostic laboratories, and medical or veterinary research. The atlas contains over 400 color images of cells from the peripheral blood and bone marrow from a variety of animals encountered in laboratory animal medicine, in health and disease.

      Key features:

      • New chapter on flow cytometry and its application in terms of routine analyses as a means of identifying abnormalities in cell marker expression, which is of particular relevance for pre-clinical safety assessment
      • Covers the most recent developments in laboratory animal hematology, including parameters measured by the latest generation of analyzers
      • Coverage of a wide range of laboratory animal species, as well as those used in clinical veterinary trials
      • Photomicrographs present normal and abnormal blood cells from a

        Trade Review

        “This book may not be useful for the typical veterinary student or practitioner, but it is an excellent resource for those involved in preclinical studies on toxicosis.” (Journal of The American Veterinary Medical Association, 15 June 2012)

        "A fine college reference!." (The Midwest Book Review, 1 November 2011)

        Table of Contents

        Foreword vii

        Introduction ix

        Dedication xi

        Acknowledgments xiii

        1 Rodents 1

        Mouse 1

        Introduction 1

        Blood picture 1

        Typical ranges (Siemens Advia 120) 2

        Hamster 15

        Introduction 15

        Blood picture 15

        Guinea Pig 17

        Introduction 17

        Blood picture 17

        Rat – Sprague Dawley (SD)/Han Wistar (HW) 18

        Introduction 18

        Blood picture 18

        Typical ranges (Siemens Advia 120) 19

        References 36

        2 Rabbit 37

        Introduction 37

        Blood picture 37

        References 39

        4 Dog 45

        Introduction 45

        Blood picture 45

        Typical ranges (Siemens Advia 120) 46

        References 64

        5 Monkey 65

        Introduction 65

        Blood picture 65

        Marmoset 66

        Cynomolgus 71

        Introduction 71

        Blood picture 71

        Typical ranges (Siemens Advia 120) 72

        Baboon 84

        Rhesus Monkey 86

        References 87

        6 Other species 89

        Pig 89

        Introduction 89

        Blood picture 89

        Horse 91

        Introduction 91

        Blood picture 91

        Goat and Sheep 94

        Assorted Other Species 96

        References 103

        3 Cat 41

        Introduction 41

        Blood picture 41

        References 44

        7 Blood collection procedures 105

        Common bleeding sites 105

        Anticoagulants 105

        Staining 105

        8 Artifacts 107

        Collection artifacts 107

        Sample transport and storage 109

        Anticoagulant 110

        Storage artifacts 111

        Blood smear preparation 113

        Stain precipitate 113

        References 114

        9 Bone marrow 115

        Introduction 115

        Review of marrow sampling techniques 115

        Recommended methods for marrow sampling 116

        Preparation and staining of smears 118

        Evaluation 119

        Interpretation 119

        References 120

        10 Comparative applications in flow cytometry 121

        Application of flow cytometry in comparative hematology 122

        References 132

        Index 135

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