Haematology Books

Book SynopsisThis book, written by respected experts, discusses in detail the latest developments in targeted therapy for hematologic malignancies using small molecules. It covers a wide range of small molecules including tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of precision cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. An accompanying volume addresses the use of small molecules in oncology, and the two volumes together represent the third edition of the book originally published under the same title. Table of ContentsImatinib .- Dasatinib .- Nilotinib .- Bosutinib .- Ponatinib .- Ruxolitinib .- Ibrutinib .- Lenalidomide .- Pomalidomide .- Enasidenib .- Midostaurin .- Alectinib .- Osimertinib .- Venetoclax .- Idelaslisib .- Carfilzomib .- Acalabrutinib.

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Book SynopsisThis textbook describes the biology of different adult stem cell types and outlines the current level of knowledge in the field. It clearly explains the basics of hematopoietic, mesenchymal and cord blood stem cells and also covers induced pluripotent stem cells. Further, it includes a chapter on ethical aspects of human stem cell research, which promotes critical thinking and responsible handling of the material.Based on the international masters program Molecular and Developmental Stem Cell Biology taught at Ruhr-University Bochum and Tongji University Shanghai, the book is a valuable source for postdocs and researchers working with stems cells and also offers essential insights for physicians and dentists wishing to expand their knowledge.This textbook is a valuable complement to Concepts and Applications of Stem Cell Biology, also published in the Learning Materials in Biosciences textbook series.Trade Review“The books ... ‘compactly and concisely discuss a specific bio-topic based on lectures for upper-level undergraduates, master’s and graduate students’: this means that both beginners and well-trained students can benefit from reading this and other books in the same collection. ... All chapters are decorated by clear and well-designed color illustrations. I am pretty sure the book will meet the reader’s expectations.” (Manuela Monti, European Journal of Histochemistry, Vol. 64, 2020)Table of Contents1. Hematopoietic stem cells2. Mesenchymal stem cells 3. Cord blood stem cells 4. Induced pluripotent stem cells 5. Epigenetic regulation in somatic cell reprogramming 6. MET in reprogramming 7. Extracellular vesicles 8. Neural stem cells 9. Neural stem cell niche 10. Human pluripotent stem cells and neural regeneration 11. Organoids 12. Ethical aspects of human stem cell research

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Book SynopsisExamination of the bone marrow has always been, and to-date techniques whose application will undoubtedly to a large extent still is, within the domain of the haema­ increase in the future. tologist. This is because smears of bone marrow aspirates After lengthy discussions and enquiries, the conclusion together with peripheral blood films and results of other was reached that the magnifications of most of the tests and investigations provided the information on which illustrations could be omitted without detracting from the usefulness of the Atlas. The magnifications used are the clinical diagnosis was based. Recently, the widespread availability of both improved indicated in Fig. 1.25. In addition, not every detail specif­ biopsy needles and techniques for processing has greatly ically indicated in a figure or its legend is necessarily increased the number of routinely taken bone biopsies mentioned in the text; and often a range of observations and placed the examination of bone marrow biopsy is illustrated and in these cases the legends are self­ sectiors also in the field of histopathology - so that explanatory. this Atlas is one of the Current Histopathology series. This Atlas is directed to haematologists and to histo­ Therefore, the haematologist and the histopathologist pathologists and to anyone interested in the investigation now complement each other in the interpretation of bone and understanding of the human bone marrow. marrow smears, imprints and sections, thus utilizing all available information and expertise to arrive at a diagnosis.Trade Review`This book is a useful quick reference because it is well organized and extensively illustrated.' The New England Journal of Medicine, 323/23 `This is an excellent book which this reviewer found readable and instructive -- it will be a great help to all haematologists trying to interpret their own marrow biopsy material.' British Journal of Haematology, 76, 1990 ` The Atlas of Bone Marrow Pathology ... will be an invaluable addition to the library of hematology and pathology laboratories using plastic embedding for bone marrow biopsies; it is comprehensive, excellently illustrated, and well referenced.' Journal of the National Cancer Institute, 83:1, 1991 Table of Contents1 Biology, structure and components of normal bone marrow.- 2 Hypoplasias (aplasias).- 3 Hyperplasias.- 4 Stromal reactions in hypoplasias and inflammatory conditions (infections).- 5 Primary and secondary myelodysplastic syndromes.- 6 Acute leukaemias.- 7 Chronic myeloproliferative disorders.- 8 Lymphoproliferations in the bone marrow.- 9 The mononuclear phagocyte system (reticuloendothelial system).- 10 Metastases in the bone marrow.- 11 Bone marrow in osteopathies.

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