Molecular biology Books
Elsevier Science Hormones
Book SynopsisTable of Contents1. Introduction 2. Steroid Hormones: Chemistry, Biosynthesis, and Metabolism 3. The Hypothalamus and Anterior Pituitary 4. Posterior Pituitary Hormones 5. Thyroid Hormones 6. Pancreatic Hormones: Insulin and Glucagon 7. Gastrointestinal Hormones 8. Eicosanoids 9. Calcium-Regulating Hormones: Vitamin D, Parathyroid Hormone, Calcitonin & Fibroblast Growth Factor-23 10. Adrenal Corticoids 11. Hormones of the Adrenal Medulla 12. Androgens 13. Estrogens and Progestins 14. Hormones of Pregnancy, Parturition and Lactation 15. Hormones Related to the Kidney and Cardiovascular System 16. The Pineal Gland 17. Growth Factors
£999.99
Elsevier Science Diagnostic Molecular Biology
Book SynopsisTable of Contents1. Nucleic Acids: DNA and RNA 2. Nucleic Acid-Based Cellular Activities - DNA Replication, Damage, and Repair 3. Gene Expression: Transcription of the Genetic Code 4. Gene Expression: Translation of the Genetic Code 5. The Genome 6. Extraction and Purification of Nucleic Acids 7. Quantification and Analysis of Nucleic Acids 8. Extraction and Purification of Proteins 9. Quantification and Analysis of Proteins 10. Amplification of Nucleic Acids 11. Characterization of Nucleic Acids and Proteins 12. Techniques in Sequencing 13. Genome and Transriptome Analysis 14. Molecular Diagnosis of Chromosomal Disorders 15. Molecular Diagnosis of Gene Mutation and Inherited Diseases 16. Molecular Diagnosis of Infectious Diseases 17. The Biology of SARS-CoV-2 and the Molecular Diagnosis of COVID-19 18. Guidance for Molecular Diagnostic Laboratory
£999.99
£132.05
Elsevier Science Helicase Enzymes Part B
Book SynopsisTable of Contents1. Crosslinking immunoprecipitation of Upf1 in yeast Kristian Baker 2. Biochemical Analysis of the SARS-CoV-2 Nsp13 Helicase Implicated in COVID-19 Robert Brosh 3. Bulk phase biochemistry of the Pif1 helicase Matthew Bochman 4. Translational control by helicases during cellular stress Tim Bolger 5. Measuring DDX3-dependent protein synthesis in vitro and in cells Stephen Floor 6. Purification of Mtr4 and Mtr4-mediated complexes Sean Johnson 7. Plan of attack for studying DEAD-box proteins Katrin Karbstein 8. Reconstitution, purification, and activity characterization for RNA-guided helicase-nuclease machines in Type I CRISPR-Cas systems Ailong Ke 9. Helicase mediated vectorial folding of G-quadruplex Sua Myong 10. Detecting G4 quadruplex unwinding Katrin Paeschke 11. Monitoring RNA and ATP-dependent conformational changes in RIG-I-like receptors using fluorescence microscopy Anna Marie Pyle 12. ATP utilization measurements in RNA unwinding and RNA chaperone activities by helicase proteins Rick Russell 13. Hydrogen-Deuterium Exchange Mass Spectrometry of RNA Helicases Sheena D'Arcy 14. Biochemical characterization of human MTR4-RNA exosome and adaptor complexes Christopher D. Lima 15. Study of RNA helicases with magnetic tweezers Herve Le Hir 16. Single-molecule FRET to analyze the dynamics of RNA helicases Dagmar Klostermeier 17. Transcriptional regulation by a RecQ helicase Sudha Sharma 18. In vitro characterization of the DEXH helicase Dhr1 from yeast Arlen Johnson
£131.10
Taylor & Francis Ltd Metagenomics and Microbial Ecology
Book SynopsisMicroorganisms comprise the greatest genetic diversity in the natural ecosystem, and characterization of these microbes is an essential step towards discovering novel products or understanding complex biological mechanisms. The advancement of metagenomics coupled with the introduction of high-throughput, cost-effective NGS technology has expanded the possibilities of microbial research in various biological systems. In addition to traditional culture and biochemical characteristics, omics approaches (metagenomics, metaproteomics, and metatranscriptomics) are useful for analyzing complete microbial communities and their functional attributes in various environments. Metagenomics and Microbial Ecology: Techniques and Applications explores the most recent advances in metagenomics research in the landscape of next-generation sequencing technologies. This book also describes how advances in sequencing technologies are used to study invisible microbes as well as the rTable of ContentsSection-I: An Overview of MetagenomicsPrinciples and analysis of Metagenomics dataSection-II: Metagenomics tools to access microbial diversityMetagenomics tools for taxonomic annotationSection-III: Metagenomics of extreme environmentsMetagenomic insights into Microbial communities of desert ecosystemsMetagenomic approaches in elucadation of halophiles in coastal areaMetagenome assembly for functional diversity associated with Xenobiotic degradationSection-IV: Metagenomics of various ecotypesEarthworm gut microbiome: The uncharted microbiomeMetagenomics of pollen borne microbes and gut microbiota of honey beeViral metagenomics Fresh water Metagenomics: Overall scenarioSection-V: ApplicationsMicrobiomes and Microbial Ecology in Rice EcosystemsUnderstanding the Ecosystem Services of Microbes: It’s a small world after all Commercial exploitation of microbial communal services to enrich plant microbiome
£99.75
CRC Press Microbial Diversity in Honeybees
Book SynopsisHoneybees are an important link in our food chain because they are major pollinators of food crops. In recent years, honeybee populations have declined precipitously perhaps due to changes in their microbiome. This book describes and identifies the bee microbiome using a proteomics technology. Chapters include the detection and identification of microbes found in honeybees collected around the United States. This book contains new data and illustrates the rich diversity of microbes as collected by honeybees. It is a must read for everyone concerned about the honeybee and working in the industry.Table of ContentsPreface. Acknowledgments. Author/Editor Biographies. Abstract. List of Abbreviations. Microbe Diversity in Honeybees. Mass Spectrometry Proteomics. Apis. Bee Gut. Coronavirus. Bacteria. Fungi. Nosema. Viruses. Water Microbes (EPA Standards). Discussion. Bibliography. Appendix A – National Average for Bacteria. Appendix B – California Region Average for Bacteria. Appendix C – Florida Region Average for Bacteria. Appendix D – Idaho Region Average for Bacteria. Appendix E – Iowa Region Average for Bacteria. Appendix F – Montana Regional Average for Bacteria. Appendix G – National Average for Fungi. Appendix H – California Region Average for Fungi. Appendix I – Florida Region Average for Fungi. Appendix J – Idaho Region Average for Fungi. Appendix K – Iowa Region Average for Fungi. Appendix L – Montana Region Average for Fungi. Appendix M – National Average for Viruses. Appendix N – California Region Average for Viruses. Appendix O – Florida Region Average for Viruses. Appendix P – Idaho Region Average for Viruses. Appendix Q – Iowa Region Average for Viruses. Appendix R – Montana Region Average for Viruses. Index.
£43.69
CRC Press Virus Bioinformatics
Book SynopsisViruses are the most numerous and deadliest biological entities on the planet, infecting all types of living organismsâfrom bacteria to human beings. The constantly expanding repertoire of experimental approaches available to study viruses includes both low-throughput techniques, such as imaging and 3D structure determination, and modern OMICS technologies, such as genome sequencing, ribosomal profiling, and RNA structure probing. Bioinformatics of viruses faces significant challenges due to their seemingly unlimited diversity, unusual lifestyle, great variety of replication strategies, compact genome organization, and rapid rate of evolution. At the same time, it also has the potential to deliver decisive clues for developing vaccines and medications against dangerous viral outbreaks, such as the recent coronavirus pandemics. Virus Bioinformatics reviews state-of-the-art bioinformatics algorithms and recent advances in data analysis in virology. FEATURES Contributions from leading international experts in the field Discusses open questions and urgent needs Covers a broad spectrum of topics, including evolution, structure, and function of viruses, including coronaviruses The book will be of great interest to computational biologists wishing to venture into the rapidly advancing field of virus bioinformatics as well as to virologists interested in acquiring basic bioinformatics skills to support their wet lab work.
£52.00
CRC Press Microbial Bioprocessing of Agrifood Wastes
a huge range and FREE tracked UK delivery on ALL orders.
£142.50
CRC Press Bioprocess Engineering and Technology
a huge range and FREE tracked UK delivery on ALL orders.
£114.00
CRC Press Bioprocess Engineering and Technology
a huge range and FREE tracked UK delivery on ALL orders.
£114.00
Taylor & Francis Ltd Microbiomes and Their Functions
Book SynopsisThis book provides a fundamental understanding of the importance of the microbiome in the life of virtually all multicellular organisms. It explains why microbes are an integral part of living organisms and describes the diverse roles they perform for their hosts. Although the significance of modified bacteria such as the mitochondrion and chloroplast is deeply rooted in the evolution of all complex organisms, it is only recently that the contribution of microbial partners within and on their hosts is becoming fully evident. These communities of microbes are as essential to organisms as are the visible organs. Microbiomes are indeed invisible organs. They participate in the digestive process, assist in communication networks, supply essential nutrients, guard against foreign intrusion, promote development and contribute to well-being. This unique approach, where the dependence of the hosts on their microbiomes is explained, will be a must-read for undergraduate and graduate studentsTable of ContentsChapter 1: The Genesis of Life – How it All StartedChapter 2: Algae and Their MicrobiomesChapter 3: Fungal Microbiome and Mycobiome Within Other OrganismsChapter 4: Microbiomes of Sedentary Aquatic OrganismsChapter 5: Insect Microbiome: Microbes Insects Depend OnChapter 6: Fish Microbiome: Functional PerspectivesChapter 7: Microbial Constituents of Birds: Genesis, Functions and AdaptationsChapter 8: Mammalian Microbiomes: The Roles They PerformChapter 9: Plants and Their Microbial Communities
£58.89
CRC Press BIOS Instant Notes in Molecular Biology
Book SynopsisInstant Notes in Molecular Biology, Fourth Edition is the perfect text for undergraduates looking for a concise introduction to the subject, or a study guide to use before examinations. Each topic begins with a summary of essential factsâ'an ideal revision checklistâ'followed by a description of the subject that focuses on core information, with clear, simple diagrams that are easy for students to understand and recall in essays and exams.Table of ContentsA. Information Processing and MacromoleculesB. Properties of Nucleic AcidsC. Prokaryotic and Eukaryotic Chromosome StructureD. DNA ReplicationE. DNA Damage, Repair and RecombinationF. Transcription in ProkaryotesG. Regulation of Transcription in ProkaryotesH. Transcription in EukaryotesI. Regulation of Transcription in EukaryotesJ. RNA Processing and RNPsK. The Genetic Code and tRNAL. Protein SynthesisM. Bacteriophages and Eukaryotic VirusesN. Cell Cycle and CancerO. Gene ManipulationP. Cloning VectorsQ. Gene Libraries and ScreeningR. Analysis and uses of Cloned DNAS. Functional Genomics and the new Technologies
£27.99
Elsevier Science Methods for the Study of Microbial Biofilms
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£113.40
Elsevier Science Animal Models of Disease Part D
£157.50
Elsevier Science Fluorine Metabolism Transport and Enzymatic
Book Synopsis
£131.10
Elsevier Science New Developments in Redox Biology
£146.69
Cambridge University Press Horizontal Gene Transfer in the Evolution of Pathogenesis 16 Advances in Molecular and Cellular Microbiology Series Number 16
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£98.99
Taylor & Francis Inc Cellular Signal Processing
Book SynopsisCellular Signal Processing offers a unifying view of cell signaling based on the concept that protein interactions act as sophisticated data processing networks that govern intracellular and extracellular communication. It is intended for use in signal transduction courses for undergraduate and graduate students working in biology, biochemistry, bioinformatics, and pharmacology, as well as medical students. The text is organized by three key topics central to signal transduction: the protein network, its energy supply, and its evolution. It covers all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling, and also highlights the clinical aspects of cell signaling in health and disease. This new edition includes expanded coverage of prokaryotes, as well as content on new developments in systems biology, epigenetics, redox signaling, and small, non-coding RNA signaling.Table of Contents1. The "Brain of the Cell": Data Processing by Protein Networks 2. Supplying the Network with Energy: Basic Biochemistry of Signal Transduction 3. Evolution of Cellular Data Processing 4. Basic Equipment: G-Proteins, Second Messengers, and Protein Kinases 5. Signal Transduction by Receptors with Seven Transmembrane Domains 6. Signal Transduction by Serine/Threonine Kinase-Coupled Receptors 7. Signal Transduction by Tyrosine Kinase- and Protein Phosphatase Coupled Receptors 8. Eukaryotic Gene Transcription: The Ultimate Target of Signal Transduction 9. Signals Controlling mRNA Translation 10. Signal Transduction by Small G-Proteins: The Art of Molecular Targeting 11. Mitogen-activated Protein Kinase and Nuclear Factor κB Modules 12. Regulation of Cell Division 13. Signal Transduction by Proteolysis, and Programmed Cell Death 14. Signal Transduction by Ions 15. Sensory Signal Processing 16. Signaling at Synapses: Neurotransmitters and their Receptors 17. Putting Together the Pieces: The Approach of Systems Biology
£65.54
Royal Society of Chemistry From DNA Photolesions to Mutations Skin Cancer
Book SynopsisAs modern day society takes an increasing interest in outdoor activities, its exposure to sunlight has never been greater. As a consequence, countries throughout the world are experiencing a dramatic increase in the incidences of skin carcinomas and melanomas. From DNA photolesions to mutations, skin cancer and cell death provides an authoritative source of information for photobiologists interested in the series of genetic events that occur in the skin, and eventually lead to cancer. With contributions from eminent scientists in the field, this book includes the latest information on DNA photolesions and repair, as well as the key mechanisms of solar UV in skin cancer initiation and development. Significant information relating to UV-induced photolesions and mechanisms of skin tumour occurrence is also included. By providing the basic phenomena underlying the science and an overview of the biological events that take place when cells are exposed to solar UV radiation, From DNA photoleTable of ContentsChapter 1: UVB and UVA Induced Formation of Photoproducts within Cellular DNA; Chapter 2: Chemical Sequencing Profiles of Photosensitized DNA Damage; Chapter 3: DNA damage induced by UVA radiation: role in solar mutagenesis; Chapter 4: Mutations induced by UV and sunlight; Chapter 5: Mechanisms and Mutagenic Consequences of Photoproduct Bypass by Replicative and DNA Damage Bypass Polymerases; Chapter 6: The Ogg1 Protein of Saccharomyces cerevisiae: Properties and Biological Functions; Chapter 7: The role of a yeast homologue of the human phosphatase activator hPTPA in the cellular response to oxidative DNA damage; Chapter 8: DNA repair in RNA polymerase I transcribed genes; Chapter 9: Global Genome Nucleotide Excision Repair: Key Players and Their Functions; Chapter 10: Efficient Repair of UV-Induced DNA Damage in Terminally Differentiated Human Keratinocytes; Chapter 11: Reactivation of UV-damaged viruses and reporter genes in mammalian cells; Chapter 12: Transcription of p53-regulated genes under transcriptional stress: implications for nucleotide excision repair; Chapter 13: What a difference a wavelength makes: The role of p53 in nucleotide excision repair of UV-induced DNA damage; Chapter 14: p53 and p33ING1: Role in Nucleotide Excision Repair of UV-Damaged DNA; Chapter 15: Nuclear and Non-Nuclear Signals Leading to UV-induced Apoptosis; Chapter 16: Opposing roles of UV-induced apoptosis in early skin cancer; Chapter 17: Acquired activation of signalling pathways in skin tumours from DNA repair-deficient xeroderma pigmentosum patients; Chapter 18: Chaos Theory and Self-Organized Criticality Describe the DNA Damage Signal transduction Network;
£161.45
Royal Society of Chemistry Essentials of Nucleic Acid Analysis
Book SynopsisOver the last decade there has been a rapid development of molecular techniques, with an increasing range of instrumentation now available. The development of accompanying reference literature has not kept pace with technological advances and this poses significant challenges to the analyst. Essentials of Nucleic Acid Analysis sets out to guide the analyst through the steps needed to obtain good quality results in DNA analysis. The underlying principles for achieving this goal were formulated by LGC (formerly the Laboratory of the Government Chemist) as the six principles for ensuring valid analytical measurement, which are detailed in the introduction. The reader is also provided with guidelines for method validation and quality control of established and emerging DNA measurement techniques. The authors of each chapter are practitioners of the art of DNA analysis in areas where the quality of the result is critical. Technical details and examples of application of key techniques in nuTrade Review"...it is a book that is recommended reading for anyone involved in the analysis of nucleic acids, particularly those using PCR-based techniques." * Annals of Botany, doi: 10.1093/aob/mcp135 *Table of ContentsChapter 1: Valid Analytical Molecular Biology: The Challenge; Chapter 2: Quality in the Analytical Molecular Biology Laboratory; Chapter 3: An Introduction to Method Validation; Chapter 4: DNA Extraction; Chapter 5: DNA Quantification; Chapter 6: PCR: Factors Affecting Reliability and Validity; Chapter 7: Quantitative Real-time PCR Analysis; Chapter 8: Multiplex PCR and Whole Genome Amplification; Chapter 9: Procedures for Quality Control of RNA Samples for Use in Quantitative Reverse Transcription PCR; Chapter 10: Microarrays
£126.34
Cambridge University Press Biological Organization
Book SynopsisLiving systems are complex systems made of components that tend to degrade, but nonetheless they maintain themselves far from equilibrium. This requires living systems to extract energy and materials from the environment and use them to build and repair their parts by regulating their activities based on their internal and external conditions in ways that allow them to keep living. The philosophical and theoretical approach discussed in this Element aims to explain these features of biological systems by appealing to their organization. It addresses classical and more recent issues in philosophy of biology, fromorigins and definitions of life to biological teleology and functions, from an original perspective mainly focused on the living system, its physiology and behavior, rather than evolution. It discusses and revises the conceptual foundations of this approach and presents an updated version of it. This title is also available as Open Access on Cambridge Core.
£17.00
Taylor & Francis Ltd Mammalian Heme Peroxidases
Book SynopsisMammalian heme peroxidase enzymes play a critical role in innate immune responses and disease prevention. The formation of potent chemical oxidants is essential to this protective physiologic activity in immunity. Although highly beneficial in the context of immune defense, it is now well established that peroxidases and their overproduction of oxidants contribute to the initiation and persistence of many chronic inflammatory conditions in the cardiovascular, neurologic, respiratory, renal, and gastrointestinal systems. Peroxidasins, a protein family related to heme peroxidases, play a novel role in tissue biogenesis and matrix assembly, which are also attracting attention in different pathological contexts. Given the diverse roles of mammalian heme peroxidases and the breadth and incidence of pathologies associated with these enzymes, there has been significant interest in modulating peroxidase activity as a therapeutic strategy. This book highlights recent developments in our undeTable of ContentsSECTION 1: INTRODUCTION TO MAMMALIAN HEME PEROXIDASES Structure, function, phylogeny of heme peroxidases Biosynthesis of MPO and other heme peroxidases Peroxidasin structure and function SECTION 2: REACTIVITY OF PEROXIDASE OXIDANTS Reactivity of peroxidase oxidants with proteins and proteoglycans Reactivity of peroxidase with nucleic acids, RNA and DNA Reactivity of peroxidase oxidants with lipids – modification and signaling Role of MPO in the modification of lipoproteins (LDL and HDL) Regulation of cellular signaling and survival by peroxidase oxidants Global profiling of cell responses to peroxidase oxidants SECTION 3: PEROXIDASES IN INNATE IMMUNITY MPO and immune cell recruitment and activation Role of MPO in extracellular trap release by neutrophils Imaging HOCl production by neutrophils How microbes combat reactive chlorine species Priming the innate immune system to combat respiratory disease SECTION 4: PEROXIDASES IN PATHOLOGY Imaging the reactivity of MPO in vivo Role of MPO in vascular dysfunction and signaling MPO in ischemic heart disease Role of MPO in neurodegenerative disease Role of MPO in kidney disease Role of peroxidases in respiratory disease Role of peroxidasins in disease SECTION 5: PREVENTION OF MPO INDUCED DAMAGE Design and functionality of MPO inhibitors Modulation of disease using MPO inhibitors Novel peroxidase inhibitory protein “SPIN” with broad target specificity Selenium and resistance to oxidative enzyme inactivation
£43.69
Taylor & Francis Ltd MultiPronged Omics Technologies to Understand
Book SynopsisCOVID-19 and Omics Technologies is a comprehensive, integrative assessment of recent information and knowledge collected on SARS-CoV-2 and COVID-19 during the pandemic based on omics technologies. It demonstrates how omics technologies could better investigate the infectious disease and propose solutions to the current concerns.The value of multi-omics technologies in understanding disease etiology and host response, discovering infection biomarkers and illness prediction, identifying vaccine candidates, discovering therapeutic targets, and tracing pathogen evolution is discussed in this book. These factors combine to make it a valuable resource to enhance understanding of both Omics technology and COVID-19 as a disease. The book covers the most recent understanding of COVID-19 and the applications of cutting-edge studies, making it accessible to a large multidisciplinary readership.The book explains how high-throughput technologies and systems biology might assist to Table of ContentsClinical and Epidemiological Context Of COVID-19. NGS technologies for detection of SARS-CoV-2 strains and mutations. Mass-spectrometry techniques for detection of COVID-19 viral and host proteins using naso-oropharyngeal swab and plasma. Targeted proteomic approaches in context of the COVID-19 pandemic. Metabolomics: Role in pathobiology and therapeutics of COVID-19. Protein microarrays for COVID-19 research: biomarker discovery, humoral response & vaccine targets. COVID-19 pathogenesis and host immune response. Putative role of multi-omics technologies in the investigation of the persistent effects of COVID-19 on vital human organs. Insights on interactomics driven drug repurposing to combat COVID-19. Spectroscopy methods for SARS-CoV-2 detection. Role of AI and ML in empowering and solving problems linked to COVID-19 pandemic.
£112.50
CRC Press Genetics Genomics and Breeding of Bamboos
Book SynopsisThis book entitled Genetics, Genomics and Breeding of Bamboos provides a comprehensive overview on the economically and ecologically important non-timber plant group bamboo. The book focuses on the most recent advances in bamboo research in diverse fields including botany, genetic resources, traditional and molecular breeding, disease and pest resistance, tissue culture and genetic transformation and genomics perspective. The different chapters are authored by internationally reputed experts on this plant and is a good source of information for students, scientists, farmers, and bamboo resource management advisers on this plant, which is gaining increase importance on international commerce.
£64.68
CRC Press Mushrooms
Book SynopsisThere are around 1.5 million fungal species worldwide. Out of these around 14,000 species produce fruiting bodies known as mushrooms, and around 2000 species are edible, and only 270 are reported to be medicinal. The fungal kingdom is phylogenetically closer to humans than plants, so gives better health benefits to human systems.This book educates readers on the nutritional, pharmaceutical and medicinal values of different mushrooms and their utilization as nutraceuticals and functional foods for human security. It reviews the current knowledge on the distribution of edible mushrooms, its general characteristics, morphology, nutritional profile and properties, pharmacological importance, and biological activities. Health benefits of mushrooms, antioxidant and secondary metabolite profiling, major biological activities of mushroom-derived secondary metabolites, functional foods based on the mushrooms open doors for therapies, products with added value, toxicology, and side effects if any are also highlighted.The book is intended for a large and varied audience â researchers, scientists, and scholars in academia, mushroom growers and industries, nutritionists, dietitians, food scientists, clinicians, doctors, drug industries, pharmacy, biotechnologists, biochemists, botanists, mycologists, and general masses.
£56.99
CRC Press Microbial Genetics
Book SynopsisThis comprehensive book explores both the fundamental and practical aspects of microbial genetics, shedding light on viroids, viruses, phytoplasma, bacteria, fungi, and protozoa. Unveiling a fresh perspective, the book tackles traditional taxonomical debates by embracing DNA-based taxonomy, offering a novel approach to understanding phylogeny within this microbe realm. Furthermore, it delves into the exciting realm of metagenomics, revolutionizing the identification and classification of unculturable microorganisms. Written by leading experts, this essential reading material caters to students and researchers in Microbiology, Genetics, and Biotechnology.
£147.25
Taylor & Francis Ltd Forensic DNA Applications
Book SynopsisForensic DNA Applications: An Interdisciplinary Perspective, Second Edition is fully updated to outline the latest advances in forensic DNA testing techniques and applications. It continues to fill the need for a reference book for people working in the field of forensic molecular biology testing and research as well as individuals investigating and adjudicating cases involving DNA evidence, whether they be civil or criminal cases. DNA techniques have greatly impacted obvious traditional forensic areas, but such advances have also positively affected myriad new areas of research and inquiry. It is possible today to think about solving forensic problems that were simply unheard of even a few years ago. As such, the book pulls all relevant research and applied science together into a detailed and comprehensive collection.Part I begins with the history and development of DNA typing and profiling for criminal and civil purposes. It discusses the statistical interpTrade Review"The most comprehensive volume on forensic and ancestral DNA analysis yet published… a valuable reference volume for practitioners and a potential textbook for upper-division and graduate courses in forensic biology." – From the Foreword by R.E. Gaensslen, Professor Emeritus, Forensic Science, University of Illinois, Chicago, Illinois, U.S.A.Table of ContentsPart I: General Background and Methodological Concepts 1. Basic Genetics and Human Genetic Variation 2. Forensic DNA Analysis and Statistics 3. Forensic Aspects of mtDNA Analysis 4. Y-Chromosome in Forensic Science 5. Forensic Application of X-Chromosome STRs 6. Increasing the Efficiency of Typing Challenged Forensic Biological Samples 7. Mixtures and Probabilistic Genotyping 8. Rapid DNA Part II - Uses and Applications 9. Collection and Preservation of Physical Evidence 10. Mass Disaster Victim Identification by DNA 11. Bioterrorism and Microbial Forensics 12. Forensic Animal DNA Analysis 13. Application of DNA-Based Methods in Forensic Entomology 14. Forensic Botany: Plants as Evidence in Criminal Cases and as Agents of Bioterrorism Part III – Recent Developments and Future Directions in Human Forensic Molecular Biology 15. Forensic Body Fluid and Tissue Identification 16. Evolving Technologies in Forensic DNA Analysis 17. Prediction of Physical Characteristics, Such as Eye, Hair, and Skin Color Based Solely on DNA 18. Molecular Autopsy 19. Genetic Genealogy in the Genomic Era Part IV: Law, Ethics, and Policy 20. DNA as Evidence in the Courtroom 21. Some Ethical Issues on Forensic Genetics 22. DNA in Immigration and Human Trafficking 23. DNA Databases
£58.99
CRC Press Diagnosis of Pathogenic Microorganisms Causing
Book Synopsis
£999.99
Springer-Verlag New York Inc. Borrelia burgdorferi
Book SynopsisTable of ContentsPreface…Table of Contents…Contributing Authors…1. Real-Time Microfluidic PCRs: A High-Throughput Method to Detect 48 or 96 Tick-Borne Pathogens in 48 or 96 SamplesSara Moutailler and Clemence Galon2. Direct Detection of Borrelia Species in TissuesShiva Kumar Goud Gadila and Monica E. Embers3. Purification of Borrelia burgdorferi Outer Membrane VesiclesHanna Tammisto and Kati Karvonen4. Constructing an ELISA for Detection of Anti-Borrelia in Wildlife and Agricultural AnimalsJulia Bland, Caitlin McGowan, Emma Bush, and Vett Lloyd5. A Step-by-Step Guide to Selecting an Optimal Cut-Off Value Based on the Receiver Operating Characteristic and Youden Index in Methods Designed to Diagnose Lyme DiseaseKunal Garg and Sara Campolonghi6. Adaptive Immune Response Investigation in Lyme borreliosisMihail Pruteanu, Armin Schwarzbach, and Markus Berger7. CYTOSPOT: Intracellular Staining and Detection of Cytokines by Flow Cytometer, An Alternative to LYMESPOTLuis Calderilla-Barbosa and Jose Luis Flores-Sevilla8. Use of Specific Borrelia Phages as a New Strategy for Improved Diagnostic TestsJinyu Shan, Ying Jia, and Tatjana Mijatovic9. Identification of Unambiguous Borrelia Peptides in Human Urine Using Affinity Capture and Mass SpectrometryRocio Cornero, Sumaiya Safia Irfan, Silvia Cachaco, Weidong Zhou, Ahana Byne, Marissa Howard, Hope McIntyre, Barbara Birkaya, Lance Liotta, and Alessandra Luchini10. Preparation of Borrelia Infected Mammalian Cells for Helium Ion MicroscopyKati Karvonen11. Establishing a Zebrafish Model for Borrelia Burgdorferi Infection Using Immersion and Microinjection MethodsErica Misner, Min Zhang, and Eva Sapi12. Development of Organoids to Study Infectious Host InteractionsAparajita Lahree and Leona Gilbert13. Content Analysis: An Approach to Exploring the Depiction of Tick-Borne DiseasesStephen M. Croucher14. Applying BERT and ChatGPT for Sentiment Analysis of Lyme Disease in Scientific LiteratureTeo Susnjak15. Building a Binary Classification Machine Learning Model: A Guide to Predicting Participation in a Lyme Disease Program at a Medical InstituteKunal Garg, Liria Mitzuko Fajardo-Yamamoto, Flor Cecilia Rojas-Castro, Teo Susnjak, and Leona Gilbert16. Clinical Algorithm and Diagnostic Tools for Lyme DiseaseGisell García-Bretón, Flor C. Rojas-Castro, Astrid N. Espino-Vázquez, and Liria M. Fajardo-Yamamoto17. Establishing a Pregnancy Lyme Disease BiobankStanley J. Naides18. Developing a Prospective Gestational Lyme Disease StudyGraham McLennan, Suzanne E. Dale, Laura Gillim, Vivian Weinblatt, Robert Wallerstein, and Stanley J. NaidesSubject Index List…
£151.99
Humana Press Inc. Investigations of Early Nutrition Effects on
Book SynopsisThis volume contains several reviews in the field as well as the step-by-step use of targeted and global approaches within the areas of genomics, epigenetics, proteomics, transcriptomics and metabolomics which aim to address this dilemma and to help pinpoint new treatment strategies. Chapters detail the generation of several models and methods for assessing health and provide researchers potential approaches for reversing or minimizing effects of disease. In addition, important information on disease mechanisms is provided, as each method is described in the context of a specific disease or therapeutic area. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical,Investigations of Early Nutrition Effects on Long-TerTable of ContentsPart I: Reviews 1. Nutritional Programming Effects on Development of Metabolic Disorders in Later Life Thomas Prates Ong and Paul C. Guest 2. Effects of Prenatal Nutrition and the Role of the Placenta in Health and Disease Leslie Myatt and Kent L Thornburg 3. Developmental Origins of Stress and Psychiatric Disorders Francesca L Guest and Paul C. Guest 4. Proteomic Studies of Psychiatric Disorders Paul C. Guest 5. Developmental Origins of Breast Cancer: A Paternal Perspective Camile Castilho Fontelles, Raquel Santana da Cruz, Leena Hilakivi-Clarke, Sonia de Assis, and Thomas Prates Ong 6. Point-of-care Testing and Personalized Medicine for Metabolic Disorders Francesca L. Guest and Paul C. Guest 7. Pregnancy and Lactation a Window of Opportunity to Improve Individual Health Guadalupe L. Rodríguez-González, Diana C Castro-Rodríguez, and Elena Zambrano 8. Utility of Small Animal Models of Developmental Programming Clare M Reynolds and Mark H Vickers Part II: Protocols 9. Generation of Maternal Obesity Models in Studies of Developmental Programming in Rodents Paul D Taylor, Phillippa A Matthews, Imran Y Khan, Douglas Rees, NozomiItani, Lucilla Poston 10. Generation of the Maternal Low Protein Rat Model for Studies of Metabolic Disorders Dan Ma, Susan E. Ozanne, and Paul C. Guest 11. Investigation of Paternal Programming of Breast Cancer Risk in Female Offspring in Rodent Models Camile Castilho Fontelles, Raquel Santana da Cruz, Leena Hilakivi-Clarke, Sonia de Assis, and Thomas Prates Ong 12. Studies of Isolated Peripheral Blood Cells as a Model of Immune Dysfunction Hassan Rahmoune and Paul C. Guest 13. Studies of a Neuronal Cell Line as a Model of Psychiatric Disorders Keiko Iwata 14. Assessment of Placental Transport Function in Studies of Disease Programming Amanda N. Sferruzzi-Perri 15. Assessment of Fatty Liver in Models of Disease Programming Kimberley D Bruce and Karen R Jonscher 16. Capillary Blood Sampling from the Finger Kieron Rooney 17. Physical Activity Assessment in Clinical Studies of Substance use Disorder Rhiannon Dowla, Bridin Murnion, Kia Roberts, Jonathan Freeston, and Kieron Rooney 18. Cardiopulmonary Exercise Testing Derek Tran 19. Cardiovascular Assessment in Human Research Marjan Mosalman Haghighi and Julian Ayer 20. Nutritional Programming Effects on the Immune System Donald B. Palmer 21. Small RNA Sequencing - A Technique for miRNA Profiling Lucas Carminatti Pantaleão and Susan E. Ozanne 22. Pulse-chase Biosynthetic Radiolabelling of Pancreatic Islets to Measure Beta Cell Function Paul C. Guest 23. Rapid and Easy Protocol for Quantification of Next Generation Sequencing Libraries Steve F.C. Hawkins and Paul C. Guest 24. Telomere length analysis - A Tool for Dissecting Ageing Mechanisms in Developmental Programming Jane L. Tarry-Adkins and Susan E. Ozanne 25. Qualitative and quantitative NMR Approaches in Blood Serum Lipidomics Banny Silva Barbosa, Lucas Gelain Martins, TássiaB. B. C. Costa, Guilherme Cruz, and LjubicaTasic 26. In vivo Electrical Stimulation for the Assessment of Skeletal Muscle Contractile Function in Murine Models Kaio F. Vitzel, Marco A. Fortes, Gabriel N. Marzuca-Nassr, Maria V.M. Scervino, Carlos H. Pinheiro, Leonardo R. Silveira, and Rui Curi 27. Experimental Model of Skeletal Muscle Laceration in Rats Phablo Abreu, Gabriel Nasri Marzuca-Nassr, Sandro Massao Hirabara, and Rui Curi 28. Neuropsychiatric Sequelae of Early Nutritional Modifications: A Beginner’s Guide to Behavioural Analysis Ann-Katrin Kraeuter, Paul C. Guest, and Zoltán Sarnyai 29. Hyperlocomotion Test for Assessing Behavioural Disorders Dan Ma and Paul C. Guest 30. 2D-DIGE Analysis of Eye Lens Proteins as a Measure of Cataract Formation Paul C. Guest 31. Mass Spectrometry Profiling of Pituitary Glands Divya Krishnamurthy, Hassan Rahmoune, and Paul C. Guest 32. Multiplex Immunoassay Profiling of Hormones Involved in Metabolic Regulation Laurie Stephen and Paul C. Guest 33. Time Resolved Fluorescence Assays for Quantification of Insulin Precursors in Plasma and Serum Kevin Taylor, Ian Halsall, Paul C. Guest, and Keith Burling 34. Identification of Neural Stem Cell Biomarkers by Isobaric Tagging for Relative and Absolute Quantitation (iTRAQ) Mass Spectrometry Paul C. Guest 35. Lab-on-a-chip Device for Rapid Measurement of Vitamin D Levels Harald Peter, Nikitas Bistolas, Soeren Schumacher, Cecilia Laurisch, Paul C. Guest, Ulrich Höller, and Frank F. Bier 36. Kidney Smartphone Diagnostics PR Matías-García and JL Martinez-Hurtado 37. A User-friendly App for Blood Coagulation Disorders Johannes Vegt and Paul C. Guest 38. Hormonal Smartphone Diagnostics PR Matías-García, JL Martinez-Hurtado, A Beckley, M Schmidmayr, and V Seifert-Klauss
£999.99
Arcler Education Inc Essential Bioinformatics
Book SynopsisA flood of data means that many of the challenges in biology are now challenges in computing. Bioinformatics, the application of computational techniques to analyse the information associated with biomolecules on a large-scale, has now firmly established itself as a discipline in molecular biology, and encompasses a wide range of subject areas from structural biology, genomics to gene expression studies. In this text we provide an introduction and overview of the current state of the field. We discuss the main principles that underpin bioinformatics analyses, look at the types of biological information and databases that are commonly used, and finally examine some of the studies that are being conducted, particularly with reference to transcription regulatory systems. The aims of bioinformatics are threefold. First, at its simplest bioinformatics organises data in a way that allows researchers to access existing information and to submit new entries as they are produced, e.g. the Protein Data Bank for 3D macromolecular structures . While data-curation is an essential task, the information stored in these databases is essentially useless until analysed. Thus the purpose of bioinformatics extends much further. The second aim is to develop tools and resources that aid in the analysis of data. For example, having sequenced a particular protein, it is of interest to compare it with previously characterised sequences. This needs more than just a simple text-based search and programs such as FASTA and PSI-BLAST must consider what comprises a biologically significant match. Development of such resources dictates expertise in computational theory as well as a thorough understanding of biology. The third aim is to use these tools to analyse the data and interpret the results in a biologically meaningful manner. Traditionally, biological studies examined individual systems in detail, and frequently compared them with a few that are related. In bioinformatics, we can now conduct global analyses of all the available data with the aim of uncovering common principles that apply across many systems and highlight novel feature.
£136.80
Apple Academic Press Inc. Molecular Biology: Different Facets
Book SynopsisThis volume provides a comprehensive description of the basic tenets of molecular biology, from mechanisms to its elaborate role in gene regulation. The initial sections cover the history of genetics and molecular biology. The book then goes on to highlight the significance of molecular approaches for all biological processes in both simple and complex cells.The volume incorporates the most recent research from this ever-evolving field. The authors have described experimental approaches wherever necessary to present evidence that has led to the development of important concepts and significant advances in molecular biology.Table of ContentsCell. Genes and Genetic Code. Molecular Biology of Microorganisms. Plant Molecular Biology. Genetic Manipulation by Recombinant DNA Technology. Molecular Diagnostics.
£78.84
Royal Society of Chemistry Drug Discovery for Leishmaniasis
Book SynopsisFor human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance to current treatments. Chemotherapy remains the only treatment option for the bulk of patients. However, this is largely unaffordable for most. In the past three years numerous advances in drug discovery have been made for treating this disease by exploiting diverging metabolic pathways between the Leishmania enzymes and their hosts, using nanotechnology to target the immune cell phagolysosomes where Leishmania resides. Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in Leishmania. Recent studies have shown that leishmaniasis affects some of the poorest people in the world, with 95% of fatal cases occurring in only 6 countries. With the WHO goal of eliminating this public health problem in the South-east Asia Region by 2020, this book will be important for anyone who is interested in neglected tropical diseases.Trade ReviewThis is a timely and highly relevant book that provides a comprehensive and in-depth overview of the current state and future directions of drug discovery for leishmaniasis. It has a broad scientific scope and wonderful insights from leading experts in the field which ensures that there is something for everyone, and that this book is truly a must-have for anyone working in the area of leishmaniasis. -- Dr. Steven L. Cobb, Durham University (UK) * ChemMedChem, DOI: 10.1002/cmdc.201800266 *Table of ContentsLeishmaniasis, Impact and Therapeutic Needs; Anti-leishmanial Drug Discovery: Past, Present and Future Perspectives; From Bench to Bedside: Development and Optimization of Clinical Therapies for Visceral Leishmaniasis; Drug Assay Methodology in Leishmaniasis: From the Microplate to Image Analysis; The Pursuit of Novel Anti-leishmanial Agents by High-throughput Screening (HTS) of Chemical Libraries; Omics and Their Impact on the Development of Chemotherapy Against Leishmania; In silico Tools for Target Identification and Drug Molecular Docking in Leishmania; Medicinal Chemistry Strategies to Discover New Leishmanicidal Drugs; Natural Products as a Source of New Drugs Against Leishmania; Organometallic Compounds in Chemotherapy Against Leishmania; New Avenues for Drug Delivery in Leishmania: Using Treatment of Visceral Leishmaniasis with Amphotericin B as an Exemplar; Addressing the Molecular Biology of Leishmania for Drug Development; The Physical Matrix of the Plasma Membrane as a Target: The Charm of Drugs with Low Specificity; Nutrient Transport and Sensing as Pharmacological Targets for Leishmaniasis; Carbon Metabolism as a Drug Target in Leishmania; The Redox Metabolism and Oxidative Stress in Leishmania as a Crossroads for the Lethal Effect of Drugs; DNA Topoisomerases as Promising Targets for Leishmania Chemotherapy; Molecular Basis of Drug Resistance in Leishmania; The Macrophage–Parasite Interface as a Chemotherapeutic Target in Leishmaniasis
£141.55
Royal Society of Chemistry RNA Polymerases as Molecular Motors: On the Road
Book SynopsisTo thrive, every living cell must continuously gauge and respond to changes in its environment. These changes are ultimately implemented by modulating gene expression, a process that relies on transcription by Nature’s most multivalent molecular machine, the RNA polymerase. This book covers progress made over the past decade understanding how this machine functions to compute the cellular state, from the atomistic structural level responsible for chemistry to the integrative level at which RNA polymerase interacts with the other key molecular machineries of the cell.Table of ContentsThe Transition from Transcription Initiation to Transcription Elongation: Start Site Selection, Initial Transcription, and Promoter Escape; Molecular Basis for Transcriptional Fidelity Control by RNA Polymerase II; 1RNA Polymerase as a Torsional Motor; RNA Polymerase-associated Transcription Elongation Factors; Rho Termination Factor: One Ring to Bind Them All; Global Regulation of Transcription by Nucleotides and (p)ppGpp; Helicases and the Obstructive RNAP; Transcription/Replication Conflicts, Resolution and Coregulation; Using Single-cell RNA Measurements to Decipher the Stochastic Kinetics of Transcription; Molecular Dynamics Simulations and Kinetic Network Models Elucidate RNA Polymerase Transcription Elongation Mechanisms
£999.99
Imperial College Press Computational Modeling Of Gene Regulatory Networks - A Primer
a huge range and FREE tracked UK delivery on ALL orders.
£35.15
Taylor & Francis Ltd Molecular Diagnosis
Book SynopsisThere has been a rapid introduction of nucleic acid-based analysis techniques into diagnostic laboratories and routine screening procedures. This timely book presents a concise overview of the molecular diagnosis of human disease. It focuses on the technTable of ContentsINTRODUCTION; Nucleic acids in human cells; Nucleic acid structure in micro organisms; Further reading; METHODS; Hybridization detection methods; Types of probes; Polymerase chain reaction; Separation methods; Some pitfalls in nucleic acid diagnosis; Futu
£26.08
Caister Academic Press Foodborne and Waterborne Bacterial Pathogens:
Book Synopsis
£197.10
Cold Spring Harbor Laboratory Press,U.S. Signaling by Receptor Tyrosine Kinases
Book Synopsis
£71.40
Springer International Publishing AG Nuclear Receptors in Human Health and Disease
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£999.99
Springer International Publishing AG Epigenetics in Oncology
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£98.99
Princeton University Press The Logic of Life
Book SynopsisTrade Review"Brilliant. . . . One thing the book reveals to the general reader is the interconnection of the development of biological ideas with the development of the rest of science and technology."---Jeremy Bernstein, New Yorker"[A] lucid account of man’s changing ideas about heredity. . . . It seizes and stimulates the imagination."---Arnold W. Ravin, Science"An unusual and illuminating history."---Edward Edelson, Washington Post Book World
£16.14
Taylor & Francis Inc Clinical Microbiology
Book SynopsisThis concise, beautifully illustrated book provides a convenient introduction to the basic science of medical microbiology and how this relates to clinical practice. Expanded from the prize-winning first edition to cover virology and parasitology in addition to bacteriology, this second editions explains the essentials of microbial infection and continues to provide a sound basis for developing logical diagnostic and management strategies, including the critical area of antibiotic usage. Section One focuses on the clinical with chapters centred around infections of the organ systems, while full coverage of the scientific aspects underpinning microbial disease follows in Section Two. Table of ContentsSection One: Clinical Aspects of Microbial Infection. Introduction to Clinical Microbiology. Anti-Infective Guidelines in the Hospital. The Clinical Microbiology Laboratory. Preventing Disease and Infection Control. Infections of the Blood. Infections of the Urinary Tract. Infections of the Respiratory Tract. Tuberculosis. Infections of the Liver including Viral Hepatitis. Infections of the Nervous System. Infections of the Skin, Soft Tissues, Bones and Joints. Infections in a Modern Society. Section Two: Scientific Basis of Microbial Infection. The Structure and Function of Prokaryotic and Eukaryotic Cell. The Classification of Bacteria, Fungi and Parasites. The Structure and Replication of Viruses. How Organisms Cause Disease. The Science of Anti-infective Agents and Resistance. Appendix One: Notifiable Diseases. Appendix Two: Key Point Summary of Organisms and Conditions.
£42.99
Callisto Reference Gel Electrophoresis: Basic Concepts and Principles
£94.99
Random House USA Inc Life on the Edge
Book Synopsis
£17.00
Elsevier Science Sketches of Nature
Table of ContentsPrefaceIntroduction. Chapter 1. Sunfishes (Centrarchidae). Chapter 2. Livebearing Fishes (Poeciliidae). Chapter 3. Other Freshwater Fishes. Chapter 4. Pipefishes and Seahorses (Syngnathidae). Chapter 5. Other Marine Fishes. Chapter 6. The Mangrove Rivulus. Chapter 7. Amphibians. Chapter 8. Marine Turtles. Chapter 9. Freshwater Turtles. Chapter 10. Other Reptiles. Chapter 11. Birds. Chapter 12. Rodents. Chapter 13. Other Mammals. Chapter 14. Invertebrates. Chapter 15. Intergroup Comparisons
£26.59
Taylor & Francis Ltd Human Molecular Genetics
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£171.00
Cambridge University Press Mechanisms in Molecular Biology
Book SynopsisThe new mechanistic philosophy is divided into two largely disconnected projects. One deals with a metaphysical inquiry into how mechanisms relate to issues such as causation, capacities and levels of organization, while the other deals with epistemic issues related to the discovery of mechanisms and the intelligibility of mechanistic representations. Tudor Baetu explores and explains these projects, and shows how the gap between them can be bridged. His proposed account is compatible both with the assumptions and practices of experimental design in biological research, and with scientifically accepted interpretations of experimental results.Trade Review'… philosophers will find a novel experimental perspective to add to the repertoire of characterizations of phenomena and mechanism. The book ends with a helpful recapitulation of the main points.' Lindley Darden, The Quarterly Review of BiologyTable of Contents1. Mechanisms and their discovery; 2. What is a phenomenon?; 3. How do mechanisms and phenomena relate to one another?; 4. What is the physical nature of biological mechanisms?; A recapitulation and some clarifications.
£17.00
World Scientific Publishing Co Pte Ltd Textbook Of Structural Biology
Book SynopsisThis book provides a comprehensive coverage of the basic principles of structural biology, as well as an up-to-date summary of some main directions of research in the field. The relationship between structure and function is described in detail for soluble proteins, membrane proteins, membranes, and nucleic acids.There are several books covering protein structure and function, but none that give a complete picture, including nucleic acids, lipids, membranes and carbohydrates, all being of central importance in structural biology.The book covers state-of-the-art research in various areas. It is unique for its breadth of coverage by experts in the fields. The book is richly illustrated with more than 400 color figures to highlight the wide range of structures.
£999.99
