Molecular biology Books

Book SynopsisRaff tells how and why he became an evolutionary biologist and describes some of the vibrant and living science of evolutionTrade ReviewAt once a cri de coeur from an eminent scientist on behalf of his profession, Raff's work is also an engaging and informative jaunt through the richly diverse history of evolution as a phenomenon and a course of study. * Publishers Weekly *Science teachers and students, as well as working scientists and laypersons with some knowledge of biology, will find this an interesting and inspiring book, not only about the life and work of a scientist, but the importance of science to society as well. * Foreword Reviews *Raff's book is . . . a fascinating story of how a young boy interested in natural history became a scientist . . . and also a polemic arguing about the importance of science and its defense against the powers of ignorance. * www.skepticblog.org *This is an excellent introduction to evolutionary thinking and an inspiration to those who may be just starting on their career (or those in need of a bit of encouragement to keep plugging along). . . . Highly recommended. * Choice *Once We All Had Gills strikes just the right balance of drama, humor, good stories, and science that makes not only for entertaining reading, but also delivers important insights into evolutionary biology research. * Quarterly Review of Biology *Table of ContentsPreface AcknowledgmentsPart I: Becoming a Naturalist1. Space-Time2. Layers of the Past3. An Age of Dinosaurs4. A School a Minute5. In the Natural World6. Transformations7. Going South8. Learning to Love the Bomb9. On the Road to Chiapas10. The Masked MessengerPart II: Finding Evolution, Founding Evo-Devo11. Evolution as Science12. Dining with Darwin13. Life with Sea Urchins14. Embryos Evolving15. Evolution in the Tasman Sea16. An Alternate Present17. Biology Meets Fossils Part III: Strange New World18. Darwin's Day in Court19. Creationist Makeovers20. Evolution MattersSelected BibliographyIndex

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Book SynopsisNow in full-color, the Second Edition of Human Evolutionary Genetics has been completely revised to cover the rapid advances in the field since publication of the highly regarded First Edition. Written for upper-level undergraduate and graduate students, it is the only textbook to integrate genetic, archaeological, and linguistic perspectives on human evolution, and to offer a genomic perspective, reflecting the shift from studies of specific regions of the genome towards comprehensive genomewide analyses of human genetic diversity. Human Evolutionary Genetics is suitable for courses in Genetics, Evolution, and Anthropology. Those readers with a background in anthropology will find that the streamlined genetic analysis material contained in the Second Edition is more accessible. The new edition also integrates new technologies (including next-generation sequencing and genome-wide SNP typing) and new data analysis methods, including recent data on ancient genTrade Review"I strongly recommend this book to anyone with an interest in human evolutionary genetics or anthropological genetics. It would be an ideal choice for advanced undergraduates and graduate courses on this topic, and would also be a key reference for those active in such research." - Human Genomics"This is an absolutely superb book! I have been recommending it enthusiastically to professional colleagues, graduate students, and even the occasional highly motivated undergraduate student, and the response has been overwhelmingly positive. Not only is the book unique in terms of topical coverage, but it is also extremely well executed. In fact, it is one of the best textbooks on any subject I have ever read. It belongs on the shelves of everyone interested in the genetic aspects of human evolution. There is also much of value in it for paleoanthropologists, historical linguistics, archaeologists, and human biologists (biological anthropologists), as well as for geneticists with various complementary specialties and interests." - American Journal of Human Genetics"I strongly recommend Human Evolutionary Genetics as an undergraduate textbook. At the same time, I recommend this book to any readers with an interest in human evolution or human genetics." - Human Genetics"In all honesty, there are few comparable textbooks on this subject, and this edition of Human Evolutionary Genetics really raises the bar. I wholeheartedly recommend this volume, and anticipate building a course around it in my own teaching." - The Quarterly Review of Biology"This is a very valuable, stimulating and challenging book for students, who will benefit from having had a previous grounding in basic biology, chemistry and statistics. For teachers this will also be valuable as a comprehensive review for courses in several aspects of human evolutionary genetics and as a teach‌ing aid."- Journal of Biological Education"My thanks to the authors for updating an already outstanding book; you have outdone yourselves! Buy this book." - American Journal of Human Biology"Human Evolutionary Genetics is a highly recommended textbook that helps readers understand differences in the human genome and how evolution has affected development of the genome and acquired diversity....This book is very well laid out for those who want to introduce themselves to the concepts of evolution and genetics and is a good read for advanced undergraduates and graduates, as well as geneticists, human biologists, anthropologists, and others." - Yale Journal of Biology and Medicine"I strongly recommend this book to anyone with an interest in human evolutionary genetics or anthropological genetics. It would be an ideal choice for advanced undergraduates and graduate courses on this topic, and would also be a key reference for those active in such research." - Human Genomics"This is an absolutely superb book! I have been recommending it enthusiastically to professional colleagues, graduate students, and even the occasional highly motivated undergraduate student, and the response has been overwhelmingly positive. Not only is the book unique in terms of topical coverage, but it is also extremely well executed. In fact, it is one of the best textbooks on any subject I have ever read. It belongs on the shelves of everyone interested in the genetic aspects of human evolution. There is also much of value in it for paleoanthropologists, historical linguistics, archaeologists, and human biologists (biological anthropologists), as well as for geneticists with various complementary specialties and interests." - American Journal of Human Genetics"I strongly recommend Human Evolutionary Genetics as an undergraduate textbook. At the same time, I recommend this book to any readers with an interest in human evolution or human genetics." - Human Genetics"In all honesty, there are few comparable textbooks on this subject, and this edition of Human Evolutionary Genetics really raises the bar. I wholeheartedly recommend this volume, and anticipate building a course around it in my own teaching." - The Quarterly Review of Biology"This is a very valuable, stimulating and challenging book for students, who will benefit from having had a previous grounding in basic biology, chemistry and statistics. For teachers this will also be valuable as a comprehensive review for courses in several aspects of human evolutionary genetics and as a teach‌ing aid."- Journal of Biological Education"My thanks to the authors for updating an already outstanding book; you have outdone yourselves! Buy this book." - American Journal of Human Biology"Human Evolutionary Genetics is a highly recommended textbook that helps readers understand differences in the human genome and how evolution has affected development of the genome and acquired diversity....This book is very well laid out for those who want to introduce themselves to the concepts of evolution and genetics and is a good read for advanced undergraduates and graduates, as well as geneticists, human biologists, anthropologists, and others." - Yale Journal of Biology and MedicineTable of Contents1. An Introduction to Human Evolutionary GeneticsSection I: How Do We Study Genetic Variation? 2. Organization and Inheritance of the Human Genome 3. Human Genome Variation 4. Finding and Assaying Genome DiversitySection II: How Do We Interpret Genetic Variation? 5. Processes Shaping Diversity 6. Making Inferences from DiversitySection III: Where and When Did Humans Originate? 7. Humans as Apes 8. What Genetic Changes Have Made Us Human? 9. Origins of Modern HumansSection IV: How Did Humans Colonize the World? 10. The Distribution of Diversity 11. The Colonization of the Old World And Australia 12. Agricultural Expansions 13. Into New Found Lands 14. What Happens When Populations Meet?Section V: How Is An Evolutionary Perspective Helpful? 15. Understanding the Past, Present and Future of Phenotypic Variation16. Evolutionary Insights into Simple Genetic Diseases 17. Evolution and Complex Diseases 18. Identity and Identification

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Book SynopsisWhy do the best-known examples of evolutionary change involve the alteration of one kind of animal into another very similar one, like the evolution of a bigger beak in a bird? Wouldn''t it be much more interesting to understand how beaks originated? Most people would agree, but until recently we didn''t know much about such origins. That is now changing, with the growth of the interdisciplinary field evo-devo, which deals with the relationship between how embryos develop in the short term and how they (and the adults they grow into) evolve in the long term. One of the key questions is: can the origins of structures such as beaks, eyes, and shells be explained within a Darwinian framework? The answer seems to be yes, but only by expanding that framework. This book discusses the required expansion, and the current state of play regarding our understanding of evolutionary and developmental origins.Trade Review'Wallace Arthur treats his readers to an eminently readable but still deeply rooted introduction into one of the most significant achievements of evolutionary biology: how evolutionary developmental biology put the organism back into the centre of evolutionary thinking.' Günter P. Wagner, Yale University, USA'Evo-devo deals with the multiple connections that exist between the biological processes of evolution and development. However, as an interface subject, there is a plurality of views on its content and its boundaries. In spite of that, Wallace Arthur has succeeded in writing an extremely clear and highly accessible guide to this fascinating, multifaceted discipline. Using the concept of 'developmental repatterning' as a common thread, the book provides a balanced view of evo-devo, covering its main achievements and future challenges. This is an ideal entry point for the non-specialist, but also a stimulating read for the practitioner who wants to consider her/his research in a wider perspective.' Giuseppe Fusco, University of Padova, Italy'Occasionally I feel that the field of Evolution and Development has lost its way, becoming submerged in myriad examples and details that don't expand our understanding of life. Wallace's book expounds the intellectual underpinnings of Evolution and Development, leads us through the key questions, and finally shows how the details and examples inform our future understanding. This book provides not just a guide to Evolution and Development, but also a spur to refocus and redouble our efforts to use development to help understand the evolution of life on Earth.' Peter Dearden, University of Otago, New ZealandTable of ContentsPreface; Acknowledgements; 1. What is evo-devo and why is it important?; 2. Antecedents of evo-devo; 3. Evolutionary and developmental essentials; 4. Evo-devo essentials; 5. The evolution of variations on a theme; 6. The evolutionary origins of themes and novelties; 7. The evolutionary origins of body plans; 8. Body plan features and toolkit genes; 9. Bringing it all together; Concluding remarks; Summary of common misunderstandings; References; Index.

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Book SynopsisAcute lower respiratory infections are one of the most common diseases in worldwide. Sometimes they constitute the most usual cause of death in children aged less than five years, with pneumonia like the leading origin. In Chapter One, the epidemiology (community-acquired and hospital-acquired pneumonia), causes, risk factors and clinical basic aspects of bacterial pneumonia are presented. The genus Enterococcus coexists with several Gram-positive bacteria. Chapter Two discusses how new tools must be developed to track glycopeptide resistance dissemination by using ISs as markers in epidemiological investigations across the world. Chapter Three summarises the different antibiotic resistances that are being found in enterococci isolates from food and clinical cases and also its possible relationship.

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Book SynopsisMany cancers are associated with the abnormal production of some molecules which can be measured in plasma/urine or can be detected on the surface of resected tumour tissue. These molecules are known as tumour markers. The potential uses of tumour markers are screening in the general population, differential diagnoses of symptomatic patients, clinical staging of cancer, estimating tumour volume, indicating prognosis, monitoring treatment and detecting recurrences. In order to obtain maximum clinical benefit, a tumour marker should have some characteristics. A tumour marker should be tissue-specific. The plasma level of the tumour marker should be in proportion to the size and activity of the tumour. A tumour marker should be present in plasma at a detectable level, even though tumour size is very small. A tumour marker should reflect the altered tumour characteristic as a response to therapy. Unfortunately, currently used tumour markers do not meet all of these criteria. A majority of them are present in normal, benign and tumour tissues, and unfortunately, they are not specific enough to be used for cancer screening in the general population. In addition, conventional tumour markers are poor in reflecting altered tumour behavior in response to anticancer therapy. They are of most value during follow-up appointments. Recent developments in molecular biology have led to the identification of numerous new tumour biomarkers. Firstly, the detection of DNA and RNA freely circulating in blood has provided a new perspective for the early diagnosis of cancer, patient follow-up, and assessment of therapy efficacy. Circulating free nucleic acids can originate from both malignant and non-malignant tissues. Discrimination of tumour cells is based on the presence of tumour-specific genetic and epigenetic alterations. This circulating nucleic acid-based approach is termed a liquid biopsy. Due to its non-invasive and repeatable features, liquid biopsy is a promising tool for cancer patients. It is particularly helpful in cancers where solid tissue biopsies are not feasible, and in the metastatic patients when multiple distinct tumour masses are simultaneously present. As another advantage, liquid biopsy shows the current tumour dynamics during anticancer therapy and drug sensitivities that conventional examinations fail to reflect. Secondly, self-renewable stem cells have the potential to cause cancer. If stem cells are genetically or epienetically changed, their differentiation potential becomes impaired and their proliferative capacity becomes uncontrolled. Current anticancer therapies mostly fail to eradicate cancer stem cells and instead favor expansion of the cancer stem cell pool and/or select for resistant stem cells. Thirdly, microRNAs, non-coding RNAs and transfer RNA fragments found in the bloodstream are candidate markers for the diagnosis and prognosis of different types of cancer. This book provides an overview of these new molecular tumour markers.

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Book SynopsisThis is a book that takes a unique approach to integrating knowledge in antioxidants from essentials to advances, and from basic research to clinical applications. This book presents scientific information on antioxidants in an organised, cogent, and in-depth manner. The consistent format of writing, the full-colour illustrations, and the comprehensive list of references make the book accessible and engaging. Besides its value as a textbook for undergraduate and graduate students in life science, ''Antioxidants in Biology and Medicine'' will also be a useful reference for biomedical research scientists, clinicians, and other health professionals.

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Book SynopsisThis book provides current research on G-quadruplex structures, their formation and role in biology. Chapter One summarizes the structural features of quadruplexes built by sequence extensions and site-specifically incorporated modified building blocks that have been established to induce the formation of stable, majority single G-quadruplex folding topologies, primarily from the human telomere repeat DNAs. Chapter Two discusses the G-quadruplexes and i-motifs as scaffolds for molecular engineering of DNA aptamers. Chapter Three examines the case of the natural alkaloids coptisine and chelerythrine. Chapter Four describes the G-quadruplex induced fluorescent signals that have been employed for the study of their folding and unfolding mechanism and thereby visualisation of their formation and structure. Chapter Five reviews the historical aspect of how major biological roles of G-quadruplexes have been uncovered by the use of specifically designed small molecule probes; and discusses the future applications of G-quadruplex interacting small molecules, including the development as potential drug candidates. Chapter Six focuses on the latest advances in the development of the telomerase assays and the authors further discuss the application potentiality of the assays for clinical samples.

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Book SynopsisMolecular biology as a distinct scientific discipline had its origins in chemistry and physical biochemistry, gradually emerging in the period between 1930 and the elucidation of DNA in the mid 1950s. Today this field has risen to a dominant position, and with its focus on deciphering genetic structure, it has endowed scientists with unprecedented power over life. In this fascinating study, however, Lily Kay argues that molecular biology did not evolve in a random fashion but, rather, was the result of systematic efforts by key scientists and their supporting foundations to direct the development of biological research toward a preconceived vision of science and society. The author traces and analyses the conceptual roots of molecular biology and the social matrix in which it was developed, focusing on the role of leading researchers headquartered at Caltech, and on the Rockefeller Foundation''s sponsorship of the new science. The study thus explores a number of vital, sometimes controTrade Reviewthe book has the great merit to give insight in the expectation of young American scientists and in what troubles their minds! * Cellular and Molecular Biology, vol.43, no.5, July 1997 *Table of Contents1. "Social Control:" the Rockefeller Foundation's Agenda in the Human Sciences, 1913-1933 ; 2. The Technological Frontier: Southern California and the Emergence of Life Science at Caltech ; 3. Visions and Realitites: The Biology Division in the Morgan Era ; Interlude 1 - The Protein Paradigm ; 4. From Flies to Molecules: Physiological Genetics in the Morgan Era ; 5. A Convergence of Goals: From Physical Chemistry to Bio-Organic Chemistry ; 6. The Spoils of War: Immunochemistry and Serological Genetics, 1940-1945 ; 7. Microorganisms and Macromanagement: Beadle's Return to Caltech ; 8. The Molecular Empire

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Book SynopsisIt is widely recognized that the neural basis of brain function can be fully understood only by integrating many disciplines at many levels. Studies os synaptic organization are bringing about a quiet revolution in achieving this goal, as documented by this unique book over the past 30 years. In this fifth edition, the results of the mouse and human genome projects are incorporated for the first time. Molecular biologists interested in functional genomics and proteomics of the brain will find answers here to the critical questions: what are the cell and circuit functions of gene products? Also for the first time, the reader is oriented to supporting neuroscience databases.Among the new advances covered are 2-photon confocal laser microscopy of dendrites and dendritic spines, biochemical analyses, and dual patch and multielectrode recordings, applied together with an increasing range of behavioural and gene-targeting methods. Leading experts in the best understood brain regions bring toTrade ReviewThis fifth edition of Shepherd's well-respected text is still worth having on the bookshelf . . . the regions covered are dealt with systematically and clearly. Each chapter has a similar structure, with sections on the neuronal elements present, their synaptic connections and basic circuits, their intrinsic membrane properties, synaptic actions and dendritic properties, and the functional properties of the circuits. This is all done clearly and thoroughly, packing a great deal of information into a small space . . . The synaptic organisation of the brain is a classic text, and still very much worth having and reading for anyone interested in the details of neuroscience. * Physiology News, Number 56 *Table of Contents1. Introduction to Synaptic Circuits ; 2. Membrane Properties and Neurotransmitter Actions ; 3. Spinal Cord: Ventral Horn ; 4. Cochlear Nucleus ; 5. Olfactory Bulb ; 6. Retina ; 7. Cerebellum ; 8. Thalamus ; 9. Basal Ganglia ; 10. Olfactory Cortex ; 11. Hippocampus ; 12. Neocortex

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Book SynopsisWhat is life? Fifty years after physicist Erwin Schrodinger posed this question in his celebrated and inspiring book, the answer remains elusive. In The Way of the Cell, one of the world''s most respected microbiologists draws on his wide knowledge of contemporary science to provide fresh insight into this intriguing and all-important question. What is the relationship of living things to the inanimate realm of chemistry and physics? How do lifeless but special chemicals come together to form those intricate dynamic ensembles that we recognize as life? To shed light on these questions, Franklin Harold focuses here on microorganisms - in particular, the supremely well-researched bacterium E. coli - because the cell is the simplest level of organization that manifests all the features of the phenomenon of life. Harold shows that as simple as they appear when compared to ourselves, every cell displays a dynamic pattern in space and time, orders of magnitude richer than its elements. It integrates the writhings and couplings of billions of molecules into a coherent whole, draws matter and energy into itself, constructs and reproduces its own order, and persists in this manner for numberless generations while continuously adapting to a changing world. A cell constitutes a unitary whole, a unit of life, and in this volume one of the leading authorities on the cell gives us a vivid picture of what goes on within this minute precinct. The result is a richly detailed, meticulously crafted account of what modern science can tell us about life as well as one scientist''s personal attempt to wring understanding from the tide of knowledge.Trade Review"The work is like a breath of fresh air in a scientific world otherwise obsessed with excessive reductionism."--BioEssays"Witty and erudite, this scientific book hails as a literary achievement. Comprehensive and up to date, Franklin Harold traces the roots--historical, thermodynamic, and biochemical--of today's biological revolution."--Lynn Margulis, co-author (with Dorion Sagan) of both What is Life? and What is Sex?"This book helps us understand why the search for answers to the riddle 'What is life?' is a noble quest."--Howard C. Berg, author of Random Walks in Biology

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Book SynopsisAimed at the biochemistry undergraduates, this physical chemistry textbook covers a range of matters in a student-friendly manner, with a mix of information followed by worked examples that facilitate the absorption of the topics. It contains problems along with answers at the back of the book.Trade Review"Remarkably efficient [at] putting across conceptually difficult material ... Principles and Problems will continue to be essential reading for biochemistry undergraduates." The Biochemist, June 2002Table of ContentsINTRODUCTION ; THE ENERGETICS OF CHEMICAL REACTIONS ; THE RATES OF CHEMICAL REACTIONS ; ATOMIC AND MOLECULAR STRUCTURE ; APPENDICES

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Book SynopsisThis book introduces the reader to all the key concepts and technologies needed to begin developing their own bioinformatics tools. The new edition includes more bioinformatics-specific content and a new chapter on good software engineering practices to help people working in teams.Table of Contents1. Introduction ; 2. Building Biological Databases with SQL ; 3. Beginning Programming in Perl ; 4. Numerical data analysis using R ; 5. Developing Web Resources ; 6. Software Engineering for Bioinformatics ; Appendix A: Using Command Line Interfaces ; Appendix B: Getting started with Apache HTTP Server ; Appendix C: Setting up a Linux Virtual Machine in Windows

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Book SynopsisThe Fourth Edition of The Neuron features newly updated chapters and scores of full-color figures, making it an ideal first course in the cell and molecular biology of nerve cells.Trade ReviewThe text is impressively modern, with up-to date information on the trendiest areas of neurobiology . . .the book is highly visual, with figures on virtually every page. The figures deserve special comment because they are a teacher's dream: simple and uncluttered, but conceptually powerful. Frankly, although the recommendation is often absurd, The Neuron is one of those books that really does belong on every shelf. * Nature *The format of each chapter is ideally suited for easy, enjoyable, and almost effortless learning . . . This is a superbly written and well-illustrated text covering all of the major aspects of neuroscientific knowledge . . . every neuroscientist should keep a copy handy. * Journal of Psychiatry and Neuroscience *This is a first-rate textbook for a course in cellular neurobiology for upper-level university students. My colleagues and I took it out on a shakedown cruise with a class of 250 undergraduates. The wind really caught their sails, and we sped quickly through it in the ten weeks of the academic quarter. The students appreciated the consistent clarity and the uniformity of style. The illustrations are highly conceptual and were easily understood . . . The up-to-date presentation of many exciting recent findings is a great strength. General principles are illustrated with a useful blend of data from vertebrate and invertebrate systems. * William S Messer, Jr., in The Quarterly Review of Biology *An outstanding, easily readable, and quite up-to-date overview of fundamental neurobiology. * Canadian Journal of Neurological Sciences *Table of ContentsPreface to the Fourth Edition ; I. Introduction ; 1. Signaling in the Brain ; 2. Form and Function in Cells of the Brain ; II. Electrical Properties of Neurons ; 3. Electrical Signaling in Neurons ; 4. Membrane Ion Channels and Ion Currents ; 5. Ion Channels Are Membrane Proteins ; 6. Ion Channels, Membrane Ion Currents, and the Action Potential ; 7. Diversity in the Structure and Function of Ion Channels ; III. Intercellular Communication ; 8. Intercellular Communication: How Neurons Communicate: Gap Junctions and Neurosecretion ; 9. Synaptic Release of Neurotransmitters ; 10. Neurotransmitters and Neurohormones ; 11. Receptors and Transduction Mechanisms I: Receptors Coupled Directly to Ion Channels ; 12. Receptors and Transduction Mechanisms II: Indirectly Coupled Receptor/Ion Channel Systems ; 13. Sensory Receptors ; IV. Behavior and Plasticity ; 14. The Birth and Death of a Neuron ; 15. Neuronal Growth and Trophic Factors ; 16. Adhesion Molecules and Axon Pathfinding ; 17. Formation, Maintenance, and Plasticity of Chemical Synapses ; 18. Intrinsic Neuronal Properties, Neural Networks and Behavior ; 19. Learning and Memory

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Book SynopsisFelix d'Herelle demonstrated the use and application of bacteria for biological control of insect pests. Drawing on family papers, archival sources, interviews, and d'Herelle's published and unpublished writings, William C. Summers tells the story of the scientist's life and work.Trade ReviewAwarded an honorable mention for the 1999 Professional/Scholarly Publishing Annual Award in the Biological Science category given by the Association of American Publisher. -- Scholarly Publishing Annual Award * Association of American Publishers, Professional/Scholarly Publishing Division *

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Book SynopsisThis book provides both general methods and safety considerations for the immortalization of cells and specific procedures for the immortalization of mammary, kidney, and thyroid epithelia, hepatocytes, fibroblasts, chondrocytes, lymphocytes, astrocytes, and human umbilical vein endothelium.Table of ContentsPartial table of contents: Human Keratinocyte Immortalization: Genetic Basis and Role inSquamous Cell Carcinoma Development (E. Parkinson). Safety Procedures (J. Caputo). Mapping Human Senescence Genes Using Interspecific MonochromosomeTransfer (R. Newbold & A. Cuthbert). Development of Immortal Human Fibroblast Cell Lines (L. Mayne, etal.). Immortalization of Human Bronchial Epithelial Cells (R. De Silva,et al.). Thyroid Epithelium (D. Wynford-Thomas). B-Lymphocytes (B. Bolton & N. Spurr). Megakaryocyte Cell Lines from Transgenic Mice (K. Ravid). List of Suppliers. Index.

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Book SynopsisCurrent techniques for studying biological macromolecules and their interactions are based on the application of physical methods, ranging from classical thermodynamics to more recently developed techniques for the detection and manipulation of single molecules. Reflecting the advances made in biophysics research over the past decade, and now including a new section on medical imaging, this new edition describes the physical methods used in modern biology. All key techniques are covered, including mass spectrometry, hydrodynamics, microscopy and imaging, diffraction and spectroscopy, electron microscopy, molecular dynamics simulations and nuclear magnetic resonance. Each method is explained in detail using examples of real-world applications. Short asides are provided throughout to ensure that explanations are accessible to life scientists, physicists and those with medical backgrounds. The book remains an unparalleled and comprehensive resource for graduate students of biophysics and Trade ReviewReview of first edition: '… a valuable contribution to the field. … There is nothing quite like it at the moment.' Sir Tom Blundell FRS, University of CambridgeReview of first edition: … one of the most comprehensive and highly relevant texts on biophysics that I have encountered in the last 10 years, clearly written and up-to-date … a must-have for biophysicists working in all lines of research …' Nikolaus Grigorieff, Brandeis University, MassachusettsReview of first edition: '… a wonderful up-to-date treatise on the many and diverse methods used … in the fields of molecular biophysics, physical biochemistry, molecular biology, biological physics and the new and emerging field of quantum nanobiology.' Karl J. Jalkanen, Quantum Protein Centre, Technological University of DenmarkReview of first edition: '… a valuable resource for novice and seasoned biophysicists alike.' Dan Minor, California Institute for Quantitative Biomedical Research, University of CaliforniaReview of first edition: '… the book I consult first when faced with an unfamiliar experimental technique. Both classic analytical techniques and the latest single-molecule methods appear in this single comprehensive reference.' Philip Nelson, University of Pennsylvania and author of Biological PhysicsReview of first edition: '… valuable both for students and research scientists.' Michael G. Rossmann, Hanley Professor of Biological Sciences, Purdue UniversityReview of first edition: 'A great achievement … awaits the student who reads this book … an excellent reference for the seasoned practitioner of biophysical chemistry.' Milton H. Werner, The Rockefeller UniversityReview of first edition: 'This well written, thorough, and elegantly illustrated book provides the connections between molecular biophysics and biology that every aspiring young biologist needs.' Stephen H. White, University of California at IrvineReview of first edition: '… I enthusiastically recommend Methods in Molecular Biophysics to anyone who wishes to know more about the techniques by which the properties of biological macromolecules are determined.' David Worcester, University of MissouriReview of first edition: 'A book that teaches the methods well, creates the intellectual framework of our understanding, and can guide the field. Earlier efforts by Cohn and Edsall, Tanford, Edsall and Wyman, and Cantor and Schimmel have served this important purpose in the past, but the advance of time and technology has diluted the force of these classic works in contemporary Biophysics, both in the teaching and the practices of the field. How welcome, then, a clearly written, thoughtful and modern text that will serve well, both in formal courses and as a reference. The authors have built each method from its fundamental premises and principles, have successfully covered an impressive span of topics, and will be rewarded by attention from an audience that hungers for the next defining text in Molecular Biophysics.' D. M. Engelman, Yale University, New HavenTable of ContentsPreface to the first edition; Preface to the second edition; Introduction; Part I. Biological Macromolecules and Physical Tools: 1. Macromolecules in their environment; 2. Macromolecules as physical particles; 3. Understanding macromolecular structures; Part II. Mass Spectrometry: 4. Mass and charge; 5. Structure function studies; Part III. Thermodynamics: 6. Thermodynamic stability and interactions; 7. Differential scanning calorimetry; 8. Isothermal titration calorimetry; 9. Surface plasmon resonance and interferometry-based biosensors; Part IV. Hydrodynamics: 10. Biological macromolecules as hydrodynamic particles; 11. Analytical ultracentrifugation; 12. Fluorescence depolarization; 13. Dynamic light scattering and fluorescence correlation spectroscopy; Part V. Optical Spectroscopy: 14. Visible and IR absorption spectroscopy; 15. Two-dimensional IR spectroscopy; 16. Raman scattering spectroscopy; 17. Optical activity and circular dichroïsm; Part VI. Optical Microscopy: 18. Light microscopy; 19. Single molecule manipulation and atomic force microscopy; 20. Fluorescence microscopy; 21. Single-molecule detection; 22. Single-molecule manipulation; Part VII. X-Ray and Neutron Diffraction: 23. The macromolecule as a radiation scattering particle; 24. Small-angle scattering and reflectometry; 25. X-ray and neutron macromolecular crystallography; Part VIII. Electron Diffraction: 26. Electron microscopy; 27. Three-dimensional reconstruction from two-dimensional images; Part IX. Molecular Dynamics: 28. Energy and time calculations; 29. Neutron spectroscopy; Part X. Nuclear Magnetic Resonance: 30. Distances and angles from frequencies; 31. Experimental techniques; 32. Structure and dynamics studies; Part XI. Medical Imaging: 33. Radiology and positron emission tomography; 34. Ultrasound imaging; 35. Magnetic resonance imaging; References; Index of eminent scientists; Subject index.

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Book SynopsisAddressing key aspects of cancer research from an interdisciplinary perspective and presenting analytical, quantitative and computational models, this book is a pedagogical introduction to cancer for physics students and researchers, as well as a reference text for cancer biologists interested in quantitative tools and approaches from physics.Trade Review'The Physics of Cancer explores a growing field and seeks to incorporate discussions pertaining to both the physics and biology of cancer. [The authors] provide readers with a refreshing perspective on cancer research. The volume not only offers a clear description of the fundamental biological concepts of cancer development and treatment, but also introduces readers with a physics background to the developing interdisciplinary field of the physics of cancer. This new field contributes to the understanding of many aspects of cancer studies, which include cancer stem cell phenotypic switching, cell sorting, mechanics of cancer cells, cell migration, cancer metastasis, etc. Due to the advanced nature of the topic, this book will serve as a good introductory level resource for physics researchers and graduate students who are interested in learning about this interdisciplinary field.' H. Zhou, Choice'La Porta and Zapperi's book isn't just light reading for curious physicists - it can also serve to guide interested researchers into a rich interdisciplinary area.' Guido D'Amico, CERN CourierTable of ContentsPreface; 1. Introduction to the cell; 2. The biology of cancer; 3. A modeling toolbox for cancer growth; 4. Vascular hydrodynamics and tumor angiogenesis; 5. Cancer stem cells and the population dynamics of tumors; 6. Biomechanics of cancer; 7. Cancer cell migration; 8. Chromosome and chromatin dynamics in cancer; 9. Control of tumor growth by the immune system; 10. Pharmacological approaches: old and new; 11. Outlook on the physics of cancer: a new interdisciplinary area; References; Index.

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