Description

Book Synopsis
This book compares empirical discovery methods for biologically relevant molecules with serendipitous discovery and rational design, and highlights the general approach to empirical discovery and its advantanges/disadvantages.

Trade Review
"This is a valuable resource that compares empirical discovery and rational design, while also considering the strengths and limitations of empirical pathways to molecular discovery. Scientists, professionals, and students interested in general aspects of molecular discovery will find this book extremely useful." (Doody's, 19 August 2011)



Table of Contents

Acknowledgments xi

Introduction xiii

1 If It Works, It Works: Pragmatic Molecular Discovery 1

2 Empirical Miracles: Nature's Precedents for Empirical Solutions 22

3 Evolution's Gift: Natural Somatic Diversification and Molecular Design 61

4 Evolution While You Wait 103

5 The Blind Protein Maker 145

6 The Blind Shaper of Nucleic Acids 187

7 Evolving and Creating Recognition Molecules 234

8 Molecules Small and Large 275

9 An Empirical--Rational Loop Forwards 315

10 Exploring the Limits 343

Glossary 365

Bibliography 374

References in Figure Legends 440

Index 443

Searching for Molecular Solutions

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    A Hardback by Ian S. Dunn

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      Book details

      Publisher John Wiley & Sons Inc
      Published 19 January 2010
      ISBN-13 9780470146828
      978-0470146828
      ISBN-10 0470146826
      Also in:
      Chemistry Molecular biology

      Description

      Book Synopsis
      This book compares empirical discovery methods for biologically relevant molecules with serendipitous discovery and rational design, and highlights the general approach to empirical discovery and its advantanges/disadvantages.

      Trade Review
      "This is a valuable resource that compares empirical discovery and rational design, while also considering the strengths and limitations of empirical pathways to molecular discovery. Scientists, professionals, and students interested in general aspects of molecular discovery will find this book extremely useful." (Doody's, 19 August 2011)



      Table of Contents

      Acknowledgments xi

      Introduction xiii

      1 If It Works, It Works: Pragmatic Molecular Discovery 1

      2 Empirical Miracles: Nature's Precedents for Empirical Solutions 22

      3 Evolution's Gift: Natural Somatic Diversification and Molecular Design 61

      4 Evolution While You Wait 103

      5 The Blind Protein Maker 145

      6 The Blind Shaper of Nucleic Acids 187

      7 Evolving and Creating Recognition Molecules 234

      8 Molecules Small and Large 275

      9 An Empirical--Rational Loop Forwards 315

      10 Exploring the Limits 343

      Glossary 365

      Bibliography 374

      References in Figure Legends 440

      Index 443

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