Description
Book SynopsisThis book compares empirical discovery methods for biologically relevant molecules with serendipitous discovery and rational design, and highlights the general approach to empirical discovery and its advantanges/disadvantages.
Trade Review"This is a valuable resource that compares empirical discovery and rational design, while also considering the strengths and limitations of empirical pathways to molecular discovery. Scientists, professionals, and students interested in general aspects of molecular discovery will find this book extremely useful." (Doody's, 19 August 2011)
Table of ContentsAcknowledgments xi
Introduction xiii
1 If It Works, It Works: Pragmatic Molecular Discovery 1
2 Empirical Miracles: Nature's Precedents for Empirical Solutions 22
3 Evolution's Gift: Natural Somatic Diversification and Molecular Design 61
4 Evolution While You Wait 103
5 The Blind Protein Maker 145
6 The Blind Shaper of Nucleic Acids 187
7 Evolving and Creating Recognition Molecules 234
8 Molecules Small and Large 275
9 An Empirical--Rational Loop Forwards 315
10 Exploring the Limits 343
Glossary 365
Bibliography 374
References in Figure Legends 440
Index 443
