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Table of Contents
1. Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis 2. New Mechanistic Probes to Identify Novel Substrates for N-Myristoyltransferases 3. Phosphonate and a Fluorophosphonate Analogues of D Glucose 6 Phosphate as Active-Site Probes of 1L-Myo-Inositol 1 phosphate Synthase 4. Kinetic Mechanism of Nicotine-Degrading Enzyme Probed by Stopped-Flow Kinetic Analyses 5. Kinetics and Mechanism for Enzyme-Catalyzed Reactions of Substrate Pieces 6. Kinetics and Mechanism for Reactions of Enzyme Pieces 7. Evaluation of allostery for the bienzyme assembly of a 3-deoxy-D-arabino heptulosonate-7-phosphate synthase and chorismate mutase 8. Recognition and Catalysis of Reactions of Chiral Substrates by Mandelate Racemase 9. Innovative and emerging modalities of EGFR kinase inhibitors 10. Characterization of the Aminoacrylate Intermediate of Tyrosine Phenol-Lyases 11. Employing deuterium kinetic isotope effects to uncover the mechanism of (R)-3-hydroxybutyrate dehydrogenase 12. Probing the mechanism of flavin action in the oxidative decarboxylation catalyzed by salicylate hydroxylase 13. Kinetic Characterization of Methylthio-D-ribose-1-phosphate Isomerase 14. The Role of Protein Motions in Catalysis 15. The nickel-pincer coenzyme of lactate racemase: A case study of uncovering cofactor structure and biosynthesis 16. Adaptation of Transient State Methods to Reveal the Mechanism of Mammalian Dihydropyrimidine Dehydrogenase 17. Charge Resonance in Enzyme Redox Reactions 18. Motions and Allostery in Human Glucokinase 19. Kinetic Dissection of CRISPR CAS-9 20. Oxygenase PLP Chemistry 21. Electron bifurcating flavoproteins

New Experimental Probes for Enzyme Specificity

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A Hardback by Graham Moran

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    Publisher: Elsevier Science
    Publication Date: 5/26/2023 12:00:00 AM
    ISBN13: 9780443152764, 978-0443152764
    ISBN10: 0443152764
    Also in:
    Biochemistry Molecular biology

    Description

    Book Synopsis


    Table of Contents
    1. Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis 2. New Mechanistic Probes to Identify Novel Substrates for N-Myristoyltransferases 3. Phosphonate and a Fluorophosphonate Analogues of D Glucose 6 Phosphate as Active-Site Probes of 1L-Myo-Inositol 1 phosphate Synthase 4. Kinetic Mechanism of Nicotine-Degrading Enzyme Probed by Stopped-Flow Kinetic Analyses 5. Kinetics and Mechanism for Enzyme-Catalyzed Reactions of Substrate Pieces 6. Kinetics and Mechanism for Reactions of Enzyme Pieces 7. Evaluation of allostery for the bienzyme assembly of a 3-deoxy-D-arabino heptulosonate-7-phosphate synthase and chorismate mutase 8. Recognition and Catalysis of Reactions of Chiral Substrates by Mandelate Racemase 9. Innovative and emerging modalities of EGFR kinase inhibitors 10. Characterization of the Aminoacrylate Intermediate of Tyrosine Phenol-Lyases 11. Employing deuterium kinetic isotope effects to uncover the mechanism of (R)-3-hydroxybutyrate dehydrogenase 12. Probing the mechanism of flavin action in the oxidative decarboxylation catalyzed by salicylate hydroxylase 13. Kinetic Characterization of Methylthio-D-ribose-1-phosphate Isomerase 14. The Role of Protein Motions in Catalysis 15. The nickel-pincer coenzyme of lactate racemase: A case study of uncovering cofactor structure and biosynthesis 16. Adaptation of Transient State Methods to Reveal the Mechanism of Mammalian Dihydropyrimidine Dehydrogenase 17. Charge Resonance in Enzyme Redox Reactions 18. Motions and Allostery in Human Glucokinase 19. Kinetic Dissection of CRISPR CAS-9 20. Oxygenase PLP Chemistry 21. Electron bifurcating flavoproteins

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