Engineering applications of bio-materials Books

Book SynopsisThis open access volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention. Beginning with a section on the design of antisense technology and their delivery, the book continues by covering model systems developed to evaluate efficacy, both in vivo and in vitro, as well as methods to evaluate preclinically the toxicity associated with these new potential drugs, and intellectual property considerations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Antisense RNA Design, Delivery, and Analysis provides basic knowledge and a large collection of methods to facilitate the work Table of ContentsPart I: Overview 1. Introduction and History of the Chemistry of Nucleic Acids Therapeutics Michael J. Gait and Sudhir Agrawal 2. Antisense RNA Therapeutics: A Brief Overview Virginia Arechavala-Gomeza and Alejandro Garanto Part II: Design and Formulation of Antisense Technology 3. Design of Bifunctional Antisense Oligonucleotides for Exon Inclusion Haiyan Zhou 4. Design and Delivery of SINEUP: A New Modular Tool to Increase Protein Translation Michele Arnoldi, Giulia Zarantonello, Stefano Espinoza, Stefano Gustincich, Francesca Di Leva, and Marta Biagioli 5. How to Design U1 snRNA Molecules for Splicing Rescue Liliana Matos, Juliana I. Santos, Mª Francisca Coutinho, and Sandra Alves 6. Conjugation of Nucleic Acids and Drugs to Gold Nanoparticles Paula Milán-Rois, Ciro Rodriguez-Diaz, Milagros Castellanos, and Álvaro Somoza 7. Determination of Optimum Ratio of Cationic Polymers and Small Interfering RNA with Agarose Gel Retardation Assay Omer Aydin, Dilek Kanarya, Ummugulsum Yilmaz, and Cansu Umran Tunc 8. Generation of Protein-Phosphorodiamidate Morpholino Oligomer Conjugates for Efficient Cellular Delivery via Anthrax Protective Antigen Valentina Palacio-Castañeda, Roland Brock, and Wouter P.R. Verdurmen Part III: In Vitro Model Systems 9. Development and Use of Cellular Systems to Assess and Correct Splicing Defects Nuria Suárez-Herrera, Tomasz Z. Tomkiewicz, Alejandro Garanto, and Rob W.J. Collin 10. Modeling Splicing Variants Amenable to Antisense Therapy by Use of CRISPR-Cas9-Based Gene Editing in HepG2 Cells Arístides López-Márquez, Ainhoa Martínez-Pizarro, Belén Pérez, Eva Richard, and Lourdes R. Desviat 11. In Vitro Models for the Evaluation of Antisense Oligonucleotides in Skin Jeroen Bremer and Peter C. van den Akker 12. In Vitro Delivery of PMOs in Myoblasts by Electroporation Remko Goossens and Annemieke Aartsma-Rus 13. Rapid Determination of MBNL1 Protein Levels by Quantitative Dot Blot for Evaluation of Antisense Oligonucleotides in Myotonic Dystrophy Myoblasts Nerea Moreno-Cervera, Irene Gonzalez-Martinez, Rubén Artero, and Estefanía Cerro-Herreros 14. Evaluation of Exon Skipping and Dystrophin Restoration in In Vitro Models of Duchenne Muscular Dystrophy Andrea López-Martínez, Patricia Soblechero-Martín, and Virginia Arechavala-Gomeza 15. Generation of Human iPSC-Derived Myotubes to Investigate RNA-Based Therapies In Vitro Pablo Herrero-Hernandez, Atze J. Bergsma, and W.W.M. Pim Pijnappel 16. Eye on a Dish Models to Evaluate Splicing Modulation Kwan-Leong Hau, Amelia Lane, Rosellina Guarascio, and Michael E. Cheetham 17. Establishment of In Vitro Brain Models for AON Delivery Elena Daoutsali and Ronald A.M. Buijsen Part IV: In Vivo Model Systems 18. Considerations for Generating Humanized Mouse Models to Test Efficacy of Antisense Oligonucleotides Irene Vázquez-Domínguez and Alejandro Garanto 19. Generation of Humanized Zebrafish Models for the In Vivo Assessment of Antisense Oligonucleotide-Based Splice Modulation Therapies Renske Schellens, Erik de Vrieze, Ralph Slijkerman, Hannie Kremer, and Erwin van Wijk 20. Use of Small Animal Models for Duchenne and Parameters to Assess Efficiency upon Antisense Treatment Ngoc Lu-Nguyen, Alberto Malerba, and Linda Popplewell 21. In Vivo Models for the Evaluation of Antisense Oligonucleotides in Skin Jeroen Bremer and Peter C. van den Akker 22. Delivery of Antisense Oligonucleotides to the Mouse Retina Alejandro Garanto 23. Delivery of Antisense Oligonucleotides to the Mouse Brain by Intracerebroventricular Injections Tom Metz, Elsa C. Kuijper, and Willeke M.C. van Roon-Mom 24. Intrathecal Delivery of Therapeutic Oligonucleotides for Potent Modulation of Gene Expression in the Central Nervous System Zachary Kennedy, James W. Gilbert, and Bruno M.D.C. Godinho Part V: Safety and Toxicology 25. Preclinical Safety Assessment of Therapeutic Oligonucleotides Patrik Andersson 26. Preclinical Evaluation of the Renal Toxicity of Oligonucleotide Therapeutics in Mice Lucía Echevarría and Aurelie Goyenvalle 27. Protocol for Isolation and Culture of Mouse Hepatocytes (HCs), Kupffer Cells (KCs), and Liver Sinusoidal Endothelial Cells (LSECs) in Analyses of Hepatic Drug Distribution Kjetil Elvevold, Ingelin Kyrrestad, Karen Kristine Sørensen, and Bård Smedsrød Part VI: Intellectual Property 28. Patent Considerations When Embarking on New Antisense Drug Programs Laurence D.S. Gainey

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Book SynopsisINTEGRATION OF BIOMATERIALS FOR GENE THERAPY Brings industrial practitioners and researchers together to discuss how the deeper integration of biomaterial platforms could play a significant role in enabling breakthroughs in the application of gene editing for the treatment of human disease. This book comprises research and review articles from leading researchers with multidisciplinary experience. It discusses many broad topics, including nanoparticle-enabled gene therapy, inorganic nanocarrier-based gene delivery, non-viral delivery of nucleic acid, biocompatible hydrogels, silk, and polysaccharides-based gene delivery. Other gene delivery topics discussed include the use of smart and engineered biomaterials, combined therapy with growth factors and cell transportation, and the prospects and challenges in the treatment of different diseases, including cancer. This book bridges the knowledge of pharmaceutics, engineering, basic science, and clinical research fields in a way that will hTable of ContentsForeword xvii Preface xix Acknowledgment xxi 1 Biocompatible Hydrogels for Gene Therapy: Advancement and Applications 1Ankita Gupta and Swatantra K.S. Kushwaha 1.1 Introduction 2 1.2 Hydrogels Classification 3 1.3 Fabrication of Hydrogels and Its Desirable Technical Features 4 1.4 Factors to be Tuned for Gene Encapsulation in Hydrogels 4 1.5 Recent Advances on Hydrogels for Gene Delivery 6 1.6 Conclusion 9 2 Use of Polysaccharides: Novel Delivery System for Genetic Material 13Prashant Kumar, Swatantra K.S. Kushwaha, Neelottama Kushwaha, Abhishek Singh and Surya Nath Pandey 2.1 Introduction 14 2.2 Cross-Linking Techniques for Engineering Polysaccharides-Based Biomaterials 23 2.3 Approaches to Design Polysaccharide-Derived Biomaterials 26 2.4 Biomedical Applications of Polysaccharide-Derived Biomaterials 29 2.5 Advanced Biomaterials for Wound Dressings 30 2.6 Scaffolds for Tissue Engineering and Development of Bioinks for 3D Bioprinting 30 2.7 Recent Utilization of Polysaccharides 31 2.8 Toxicity Concerns of Polysaccharide-Derived Biomaterials 33 2.9 Preclinical and Clinical Studies on Gene Delivery Using Polysaccharide-Based Biomaterials 33 2.10 Challenges and Future Directions 34 2.11 Future Prospects 35 2.12 Conclusion 35 3 Polysaccharide-Based Biomaterials for Gene Delivery 47Ankita Moharana, Abhitav Tiwari, Shalini Perada, Shivlal Yadav and Om Prakash Kumar 3.1 Background 48 3.2 Introduction 49 3.3 Gene Therapy 51 3.4 Gene Delivery Systems Based on Polysaccharides 53 3.5 Practical Application of Gene Delivery Systems 56 3.6 Polysaccharide-Based Nanoparticles 57 3.7 DNA Delivery 63 3.7.1 siRNA Delivery 65 3.8 Conclusion 70 4 Hydrogel-Based Gene Therapy 77Shweta Kumari, Dipti Jena, Vedant Kumar Prajapati, Shashi Ranjan Singh and Garima Tripathi 4.1 Introduction 78 4.2 Gene Therapy 83 4.3 In Vivo Gene Therapy Using Hydrogels 86 4.4 Encapsulating Cells in Hydrogels for Gene Therapy Delivery 87 4.5 Hydrogels for Integrative Tissue Engineering and Cell Delivery 89 4.6 Biocompatible Hydrogels for Transferring Cells 91 4.7 Using Hydrogels for Gene Therapy in Tissue Engineering-Based Drug 93 4.8 Human Gene Therapy that Uses Hydrogel as an Alternative Method of Delivering Genetic Material to Patients 94 4.9 Recent Advancement in Biocompatible Hydrogel 96 4.10 Applications of Hydrogel 99 4.11 Current Hydrogels in Clinical Trials 104 4.12 Conclusions 106 5 Progress and Prospects for Non-Viral Gene Therapy 117Shashimala Tiwari 5.1 Introduction 118 5.2 Definition 118 5.3 Technology Overview for Non-Viral Gene Delivery 119 5.4 Chemical Carriers for Gene Transfer: Establishing Effective In Vivo Gene Delivery 121 5.5 Types of Gene Delivery 122 5.6 Reduction of Immunological Responses Through Alteration of Delivery Method or DNA Structure 124 5.7 To Enable Long-Lasting Gene Expression, Self-Replicating, Tissue-Specific, and Integrating Plasmid Expression Systems are Designed 124 5.8 Hybrid Vector Systems to Improve Transfection and Lessen Cytotoxicity 125 5.9 Vehicle Material 127 5.10 Further Effects 129 5.11 Challenges and Prospects 130 5.12 Conclusion 132 6 Nanoparticles for Tumor Gene Therapy: Recent Advances and Perspective 139R. Shivhare, V. Sabale, A. Ingole and Neelam Jain 6.1 Introduction 140 6.2 Technologies for Gene Delivery 142 6.3 Cancer Treatment with Gene Therapy 147 6.4 Gene Therapy Using Nanotechnology 147 6.5 Challenges and Future Aspects 160 7 Effective Gene Transfer with Non-Viral Vectors 183Anil Kumar Mavi, Sonal Gaur, Neelesh Kumar, Avanish Kumar Shrivastav, Sankha Bhattacharya,Sateesh Belemkar, Saurabh Maru and Dhruv Kumar 7.1 Introduction 184 7.2 System Development for Delivering Genes 186 7.3 Methods for Non-Viral Vector for Delivery of Genes 186 7.4 Delivery System 203 7.5 Current Methods for Nonviral Gene Delivery: Benefits and Drawbacks 209 7.6 Current Barriers for Non-Viral Vectors 210 7.7 Possibilities for Enhancing the Non-Viral Vector Delivery System 212 7.8 Conclusion 212 7.9 Future Relevance 213 8 Utilization of Chitosan for Gene Delivery 223Johnson Olaleye Oladele 8.1 Introduction 224 8.2 Cationic Polymers-Based Gene Delivery Systems 225 8.3 Chitosan and Its Derivatives in Gene Delivery Systems 228 8.4 Chitosan as Chemotherapeutic Drugs 234 8.5 Conclusion 236 9 Nanoparticles as Gene Vectors in Tumor Therapy 247 Efstathia Triantafyllopoulou, Orestis Kontogiannis, Nefeli Lagopati, Natassa Pippa and Maria Gazouli 9.1 Introduction 248 9.2 Polymer-Based Nanocarriers: Their Technology and Recent Advances 249 9.3 Conclusions 271 10 Progress in Non-Viral Delivery of Nucleic Acid: Advancement in Biomedical Technology 281Anil Kumar Mavi, Manmohan Kumar, Amarjeet Singh, Mahendra Kumar Prajapati, Rakhi Khabiya, Saurabh Maru and Dhruv Kumar 10.1 Introduction 282 10.2 Physical Methods of Non-Viral Nucleic Acid Delivery System 285 10.3 Advantages and Disadvantages of Physical Transfection 296 10.4 Chemical Methods of Non-Viral Nucleic Acid Delivery System 296 10.5 Advantages and Disadvantages of Chemical Transfection 308 10.6 Cellular Barriers for Nucleic Acid Delivery Faced by Non-Viral Vectors 309 10.7 Challenges and Limitations of Non-Viral Nucleic Acid Delivery System 311 10.8 Conclusion 311 11 The Junction of Biomaterials and Gene Therapy -- Current Strategies and Future Directions 323Ranjan Kumar Singh, Sunita Panchawat, Chennu M.M. Prasada Rao, Joohee Pradhan, Rajeswari Tanniru, Deepika Bairagee and Ajay Kumar Garg 11.1 Introduction 324 11.2 Viral Gene Therapy 327 11.3.1 Adenoviral Vectors 329 11.4 Adeno-Associated Viral Vectors 330 11.5 Non-Viral Gene Therapy 331 11.6 Recent Advances in the Development of Gene Delivery Systems 334 11.7 Development of Gene Delivery Systems 335 11.8 Viral Vectors Based on DNA for Gene Delivery Systems 336 11.9 Viral Vectors Based on RNA for Gene Delivery Systems 337 11.10 Oncolytic Viral Vectors for Gene Delivery Systems 337 11.11 Practical Application of Gene Delivery Methods 343 11.12 Conclusion 347 12 Utilization of Silk for Gene Delivery 349Swatantra K. S. Kushwaha, Shruti Khare and Neelottama Kushwaha 12.1 Introduction 350 12.2 Dimensional Structure of Silk 350 12.3 Properties of Silk 351 12.4 Extraction of Fibroin from Silk Worm 352 12.5 Fabrication of Silk in Different Therapeutics Carriers 353 12.6 Utilization of Silk for Gene Therapy 354 12.7 Properties of Silk Fibroin as Biomaterial 355 12.8 Summary of Silk-Based Formulations for Gene Delivery 357 12.9 Examples of Some Delivery Approaches which Utilizes Silk as a Biomaterial for Gene Delivery 358 12.10 Some Highlights of Silk Fibroin 360 12.11 Conclusion 360 13 Challenges and Emerging Problems in Nanomedicine Mediated Gene Therapy 367Shalini Bhatt, Neha Faridi, Rakshit Pathak, Vinay Deep Punetha and Mayank Punetha 13.1 Introduction 368 13.2 Why Nanomedicine Over Traditional Drugs? 369 13.3 Nanomedicine for Gene Therapy 373 13.4 Complications in Nanomedicine-Mediated Gene Therapy 384 13.5 Challenges in the Clinical Translation of Nanomedicines 391 13.6 Conclusion 396 14 Biomaterials-Based Vaccination in Cancer Therapy 417Rishav Sharma, Rishabha Malviya and Sonali Sundram 14.1 Introduction 417 14.2 Tumor-Associated Antigens 418 14.3 Vaccine Delivery 419 14.4 Dendritic Cells 420 14.5 In Vitro Generation of Dendritic Cells 421 14.6 Usage of RNA 422 14.7 RNA-Pulsed DCs as Vaccines 422 14.8 RNA Vaccines 425 14.9 Optimization of Immunotherapy 426 14.10 Cancer Treatment Through RNA Interference 427 14.11 Conclusion 428 References 429 Index 435

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Book SynopsisCollagen: Structure and Mechanics provides a cohesive introduction to this biological macromolecule and its many applications in biomaterials and tissue engineering. Graduate students and postdoctoral researchers in the fields of materials, (bio-)engineering, physics, chemistry and biology will gain an understanding of the structure and mechanical behavior of type I collagen and collagen-based tissues in vertebrates, across all length scales from the molecular (nano) to the organ (macro) level. Written in a clear and didactic manner, this volume includes current knowledge on the hierarchical structure, mechanical properties, in addition to a review of deformation and strengthening mechanisms. Collagen: Structure and Mechanics is an excellent reference for new researchers entering this areaand serves as a basis for lecturing in the interdisciplinary field of biological materials science.Table of ContentsCollagen: Structure and Mechanics, an Introduction.- Collagen Diversity, Synthesis and Assembly.- Collagen Fibrillar Structure and Hierarchies.- Restraining Cross-Links Responsible for the Mechanical Properties of Collagen Fibers: Natural and Artificial.- Damage and Fatigue.- Viscoelasticity, Energy Storage and Transmission and Dissipation by Extracellular Matrices in Vertebrates.- Nanoscale Deformation Mechanisms in Collagen.- Hierarchical Nanomechanics of Collagen Fibrils: Atomistic and Molecular Modeling.- Mechanical Adaptation and Tissue Remodeling.- Tendons and Ligaments: Structure, Mechanical Behavior and Biological Function.- Collagen in Arterial Walls: Biomechanical Aspects.- The Extracellular Matrix of Skeletal and Cardiac Muscle.- The Cornea and Sclera.- Collagen and the Mechanical Properties of Bone and Calcified Cartilage.- Dentin.- Genetic Collagen Diseases: Influence of Collagen Mutations on Structure and Mechanical Behavior.- Biomimetic Collagen Tissues: Collagenous Tissue Engineering and Other Applications.

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Book SynopsisThis book is a comprehensive guide to BiodentineTM, an innovative biocompatible and bioactive material based on pure tricalcium silicate that can permanently replace dentin and can also serve as a temporary enamel substitute. Although BiodentineTM has been widely used across the world for the past decade, this is the first book to be devoted to its properties, interactions with the soft and hard tissues, and its multiple clinical applications. The coverage encompasses applications in primary and permanent teeth, in specialties as diverse as restorative dentistry, endodontics, paediatric dentistry, dental traumatology, and prosthetic dentistry. BiodentineTM application both in vital pulp therapy and endodontic procedures is illustrated and clinical step by step protocols are provided. The book provides a detailed update on BiodentineTM use to preserve the pulp vitality in direct/indirect pulp capping, pulpotomy and irreversible pulpitis treatment. It also details BiodentineTM use for non-vital teeth treatment in indications such as root/furcation perforation repair, apexification as well as in regenerative endodontic procedures.BiodentineTM: Properties and Clinical Applications will be a rich source of guidance and information for all dentists as well as dental students and academics.Table of ContentsChapter 1) Biodentine Microstructure and Composition.- Chapter 2) Biodentine Physico-chemical Properties: From Interactions with Dental Tissues to Aging.- Chapter 3) Biocompatibility and Bioactive Properties of Biodentine.- Chapter 4) Biodentine in Inflammation and Pain Control.- Chapter 5) Biodentine Clinical Applications in Vital Pulp Therapy in Permanent Teeth.- Chapter 6) Biodentine: Applications in Pulpotomy of Deciduous Teeth.- Chapter 7) Biodentine Applications in Traumatology and Fractures.- Chapter 8) Biodentine Applications in Irreversible Pulpitis Management in Children and Adults.- Chapter 9) Calcium Silicate-based Cement (Biodentine TM) as a Bioactive Material for the Long-Term Preservation of Pulp Vitality in Restorative Dentistry and Prosthodontics.- Chapter 10) Biodentine Applications in Furcation Perforation and Root Resorption.- Chapter 11) Clinical Applications of Biodentine in Regenerative Endodontics/Revitalization.

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Book SynopsisThis book describes past and present advances in engineering materials for neural applications, with special emphasis on their usefulness for traumatic brain and spinal cord injuries. The book presents major physio-pathological features of traumatic injuries at the brain and spinal cord as examples of diseases hampering the central nervous tissue. By incorporating knowledge from the perspective of experts with diverse backgrounds, this book gives insight into the understanding of these multifaceted pathologies and the materials science approaches that aim to cure them. The interdisciplinary nature of this book makes it a perfect candidate for the interest of a broad audience, from clinicians working on neural diseases to scientists whose work focuses on the nervous tissue (neuroscientists) and/or materials science. Undergraduate and PhD students can also benefit from the knowledge and discussion included in this book.Table of Contents

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Book SynopsisThis book presents synthesis, characterization, and applications of macroporous, mesoporous, nanoporous, hierarchical porous, porous metals, and porous ceramics. Special emphasis is given to the preparation of porous activated carbon materials and porous ionic liquid-derived materials for CO2 emissions mitigation. Additionally, a chapter includes the physical and mathematical modeling in porous media. Many analytical techniques for characterization are discussed in this book. Also, the biomedical and industrial applications of porous materials in adsorption, catalysis, biosensors, drug delivery, nanotechnology are described. The content helps solving fundamental and applied problems in porous materials with length scales varying from macro- to nano-level. Table of Contents

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Book SynopsisThis highly illustrated textbook provides an essential overview on RNA architecture and function, it offers insights into the RNA basics and also explains novel RNA technologies, such as CRISPR-Cas and their applications. In addition, the mRNA based vaccine technology, which has long been tested, also before the COVID-19 pandemic, is discussed and students receive a basic understanding of this important medical application.The textbook is written by Prof. Grover in collaboration with her students and has an easily accessible style. The book provides a great tool for young researchers and students in biology, biomedical engineering or biochemistry, looking for a compact introduction or refresher work on RNA, including the newest findings and technologies. It is an ideal starter to learn about several RNA specific topics and to research them further.Table of Contents1. RNA-Composition and Base Pairing.- 2. Architecture of RNA.- 3. Small Catalytic RNA.- 4. The Spliceosome: A Large Catalytic RNA.- 5. A Genomic Perspective on RNA.- 6. The mRNA and the New Vaccines.- 7. Riboswitches: Sensors and Regulators.- 8. Small Non-Coding RNA, miRNA in Gene Regulation.- 9. CRISPR-Cas Systems, The science and ethics of gene manipulation.- 10. Transcription.

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Book SynopsisThis book focuses on recent advances in dental gold alloys and gold nanoparticles (GNPs) for biomedical applications. Dental gold alloys combine several highly desirable mechanical properties, such as high strength, ductility, and elasticity, with an extremely robust chemical stability in the mouth. Moreover, astonishing progress has been made in the use of GNPs as novel gold biomaterials that provide a multifunctional platform for cellular imaging, biosensing, and targeted drug delivery in tumour immunotherapy and photothermal therapy. Beginning with a comprehensive overview of the development and use of dental gold alloys, the book addresses the materials properties that are crucial for dental applications, focusing on aspects such as microstructure, chemical and mechanical stability, ageing, biocompatibility, and colour retention. The book then shifts focus to the use of GNPs in dental applications, delving into different techniques of GNP synthesis for specifically tailoring the size, shape, and stability of GNPs in biological media. In addition to these factors, it addresses how their exposure route, surface chemistry, as well as how the steric effects of their coating impact biodistribution and determine the level of GNP toxicity in the human body. Featuring topical literature reviews alongside up-to-date published experimental results, this book offers an attractive resource for practicing scientists and engineers working in the field of gold-based biomaterials.Table of Contents

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Book SynopsisThis book will serve as a one-stop, reference manual to understand the basic concepts of dental implant design, the related microbiome, research models and current concepts as well as futuristic perspectives in implant surface modification. The manual-like design including colorful illustrations and important critical questions will help researchers and advanced students in understanding the contemporary status and in designing studies for innovative treatments of dental implant infections. Considering the microbiome of dental implant related environment in health and disease is imperative to design strategies to good practice and prevention of infections around implants. This monograph will serve as a single reference material which links the interdisciplinary aspect of the dental implants covering material sciences, engineering and biological aspects, thus effectively bridging the gap between engineering and oral health sciences.Table of ContentsDental Implants – An Overview.- Oral Microbiota and Biofilm Infections.- Host Immune Response to Dental Implants.- In Vitro and In Vivo Models to Understand Dental Implant Integration.- Modern Approaches to Dental Implant Biofilm Management.- High Performance Advanced Materials.

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Book SynopsisThis book provides a holistic compilation on applications of carbon nanostructures, especially in advanced healthcare applications. It comprises chapters on utility of diverse multifunctional nanocarriers in drug delivery and biomedical applications, especially emphasizing on the synthesis and characterizations of nanosystems along with surface engineering approaches used for active targeting of the drugs. Moreover, the chapters also include the recent updates on the applications of the nanocarriers to fulfill the needs of various healthcare systems.Table of ContentsTitles Contributing author 1). Introduction to carbon nanomaterials Dr. Amit Kumar Nayak Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj-757086, Odisha, India E-mail: amitkrnayak@yahoo.co.in 2). Emergence in carbon nanotubes for drug delivery and biomedical applications Ibrahim M. El-Sherbiny, PhD, NZIC, MRS, AAPS, BMES Professor of Smart Nanomaterials & Nanomedicine, Director, Center for Materials Science (CMS), Founding Chairman, Nanoscience Program Founding Former Chairman, Materials Science Program Editor, Drug Development and Industrial Pharmacy (DDIP, USA) Editor-in-Chief, Journal of Nanotechnology & advanced Materials - Natural Sciences (USA) Vice President, National Council for New & Advanced Materials, National Council of Drug Research, HS-Board Member, National Organization for Drug Control and Research (NODCAR) Zewail City of Science and Technology Nano-Building, Room F003 Ahmed Zewail Road, October Gardens, 6th of October, 12578, Giza, Egypt Website: https://www.zewailcity.edu.eg/main/content.php?lang=en&alias=ibrahim_m._el-sherbiny e-mail: ielsherbiny@zewailcity.edu.eg 3). Graphene nanocomposites in healthcare appllications Prof. Dr. Cornelia Vasile "P.Poni" Institute of Macromolecular Chemistry Department of Physical Chemistry of Polymers 41A Grigore Ghica Voda Alley R0 700487 IASI ROMANIA e-mail: cvasile@icmpp.ro 4). Fullerenes: Bucky balls in promising therapeutic applications Prof. Sanjay K. Jain, Professor of Pharmaceutics, Head, Department of Pharmaceutical Sciences, Dr. Harisingh Gour University, Sagar (MP)-470002, India Emails: drskjainin@gmail.com, drskjainin@yahoo.com 5). Nanodiamonds as next geneation carriers in exploring therapeutic benefits Dr. Nafiu Aminu Lecturer, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, P.M.B. 2346 Sokoto, Nigeria. E-mail: nafiu.aminu@udusok.edu.ng, nabgus@yahoo.com 6). Nanographites as multidimenssional carriers for advanced therapeutic applications Dr. Wazed Ali Department of Textile and Fibre Engineering, Indian Institute of Technology Delhi, HauzKhas, New Delhi-11016, India. E-mail: wazed@textile.iitd.ac.in 7). Carbon nanohorns in drug delivery and medical applications Dr. Samuel Eshorame Sanni Department of Chemical Engineering, Covenant University, Ota, Ogun State, Nigeria E-mail: sanni@covenantuniversity.edu.ng 8). Carbon nanotorous for advanced therapeutic applications Dr. Prashant Kumar Sharma, Assistant Professor, Department of Physics, Indian Institute of Technology, (Indian School of Mines), Dhanbad 826004, India. E-mail: prashantnac@gmail.com, prashant@iitism.ac.in 9). Carbon nanobombs: Newer class of materials for multifunctional applications Dr. Mehrdad Hamidi Professor of Pharmaceutics, School of Pharmacy, Zanjan University of Medical Sciences, Iran E-mail: hamidim@zums.ac.ir 10). Bio-inspired carbon nanostructures: Advances and challenges Dr. Joash Ban Lee Tan School of Science, Monash University, Malaysia E-mail: tan.ban.lee@monash.edu 11). Functionalized carbon dots in theraputic applications Dr. Wanpen Tachaboonyakiat Department of Materials Science, Faculty of Science, Chulalongkorn University, Phayathai, Pathumwan, Bangkok 10330, Thailand. E-mail: wanpen.ta@chula.ac.th 12). Carbon quantum dots: Perspectives and Prospects Dr. Yadollah Omidi Professor of Pharmaceutical Sciences, Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, 3200 South University Drive, Davie, FL 33328, USA E-mail: yomidi@nova.edu 13). Carbon-based host-guest nanosystems in biomedical applications Dr. MiIlan MIlivojevic University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia E-mail: mmilan@tmf.bg.ac.rs 14). Carbon nanotropes with newer potential for drug delivery and biomedical applications Dr. Jaison Jeevanandam Department of Chemical Engineering, Faculty of Engineering and Sciences, Curtin University, Malaysia E-mail: jaison.jeevanandam@gmail.com 15). Carbon nanofibres in diversified healthcare applications Dr. Classius Ferreira da Silva Universidade Federal de São Paulo - UNIFESP Departamento de Engenharia Química, Laboratório de Biotecnologia e Produtos Naturais - BIONAT (3o. Andar), Brazil E-mail: classiusferreira@yahoo.com.br 16). Biosafety and toxcity evaluation of carbon nanomaterials Dr. Md Saquib Hasnain Department of Pharmacy, Shri Venkateshwara University, NH-24, Rajabpur, Gajraula, Amroha – 244236, U.P., India E-mail: msaquibhasnain@gmail.com

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Book SynopsisCorrosion Science and Engineering is now an integral part of research throughout the world. Researchers are actively looking for an alternative eco-friendly way of developing non-toxic corrosion inhibitors from natural sources. This book discusses all the recent advancements in the corrosion field with an emphasis on natural sources which is the demand of the era to replace the commercially available toxic corrosion inhibitors.

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Book SynopsisThe focus of this book is to introduce up-to-date information on applications and practical use of RNA for agriculture, biotechnology and medicine. It provides unique ideas, tools, and methods in detail from a variety of scientific and technical disciplines. RNA science has progressed enormously in recent decades, and vast amounts of information on RNA functions and their regulatory mechanisms are becoming available. Such a progress opened the door to an age of practical application of RNA in many fields including agriculture, plant science, medical science, brewing and fermentation technology, and material production. This book inspires its readership and contributes to not only expansion in application of RNA but also to basic research. Table of ContentsList of titles and authors (as of 24 Aug 2016) 1. Gene expression system that can escape from translational repression caused by brewing-related stress Shingo IZAWA 2. Bacterial cellular engineering through interspecies exchange of 16S rRNA in Escherichia coli ribosome. Kentaro MIYAZAKI 3. Development and application of the excellent protein synthesis technique with riboswitches in microorganisms Takahiro YAMAUCHI and Naoki SUGIMOTO 4. Cell Reprogramming by Lactic Acid Bacteria. Kunimasa OHTA 5. Novel detection system of mycotoxin using aptamer Yuji MORITA 6. Rational design of artificial riboswitches Atsushi OGAWA 7. mRNA engineering as a tool for controlling mammalian cells in medical applications Kei ENDO and Hirohide SAITO 8. Modulation of abnormal splicing by small chemical compounds in RNA diseases Naoyuki KATAOKA 9. Protein production system by innovating mRNA export Seiji MASUDA 10. PPR protein and the engineering Takahiro NAKAMURA 11. Long noncoding RNAs and their applications Tomohiro YAMAZAKI 12. Long non-coding RNA as new diagnostic and therapeutic targets Eleonora LEUCCI 13. Riboswitches and ribozymes as RNA-based modular tools to control gene expression Yoshiya IKAWA and Shigeyoshi Matsumura 14. Applications of CRISPR/Cas9 genome editing for functional characterization of RNA helicases Jerry PELLETIER 15. Application of systemic TGS on plant breeding Songling BAI 16. Theoretical and applied epigenetics in plants Yuhya WAKASA, Taiji KAWAKATSU, and Fumio TAKAIWA

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Book SynopsisThis book provides a compendium of material properties, demonstrates several successful examples of bio-based materials’ application in building facades, and offers ideas for new designs and novel solutions. It features a state-of-the-art review, addresses the latest trends in material selection, assembling systems, and innovative functions of facades in detail. Selected case studies on buildings from diverse locations are subsequently presented to demonstrate the successful implementation of various biomaterial solutions, which defines unique architectural styles and building functions. The structures, morphologies and aesthetic impressions related to bio-based building facades are discussed from the perspective of art and innovation; essential factors influencing the performance of materials with respect to functionality and safety are also presented. Special emphasis is placed on assessing the performance of a given facade throughout the service life of a building, and after its end. The book not only provides an excellent source of technical and scientific information, but also contributes to public awareness by demonstrating the benefits to be gained from the proper use of bio-based materials in facades. As such, it will appeal to a broad audience including architects, engineers, designers and building contractors.Table of Contents

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Book SynopsisThis book provides a concise introduction to soft matter modelling, together with an up-to-date review of the continuum mechanical description of soft and biological materials, from the basics to the latest scientific materials. It also includes multi-physics descriptions, such as chemo-, thermo-, and electro-mechanical coupling. The new edition includes a new chapter on fractures as well as numerous corrections, clarifications and new solutions. Based on a graduate course taught for the past few years at Technion, it presents original explanations for a number of standard materials, and features detailed examples to complement all topics discussed.Table of Contents

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Book SynopsisThis volume provides a thorough insight into the chemistry and mechanism of ionic gelations of various ionic biopolysaccharides, like alginate, gellan gum, pectin, chitosan, carboxymethyl cellulose, etc., and the applications of various ionically gelled biopolysaccharides in drug delivery fields, with chapters emphasizing the recent advances in the field by the experts. This book will be of interest to graduate students and academic and industry researchers from pharmacy, biotechnology, bioengineering, biomedical and material sciences fields.Table of ContentsIonically gelled pectinates in drug delivery.- Ionically gelled alginates in drug delivery.- Ionically gelled gellan gum in drug delivery.- Ionically gelled chitosan in drug delivery.- Ionically gelled carboxymethyl polysaccharides in drug delivery.- Polyelectrolyte complex-based ionically gelled biopolymeric systems for sustained drug release.- Ionically gelled polysaccharide-based interpenetrating polymer network systems in drug delivery.- Ionically gelled polysaccharide-based multiple-units in drug delivery.- Ionically gelled polysaccharide-based floating drug delivery systems.

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Book SynopsisThis book provides deep insight into the significance of various forensic techniques underlying the methodical approaches in criminal investigations. The book comprises numerous case studies, examples, and reference materials. It emphasizes on the better practices for criminal investigations including contemporary examinations. The book also describes various methods for investigation of crime scene and evidence collection including biological evidences to the resources of law enforcement agencies. This book encompasses the procedure for crime scene-documentation through photography, video, and diagrams and highlights the best practices of packaging the biological evidences at a crime scene. Further, it summarizes the role of forensic autopsy to the criminal investigation system. As such, the book is helpful for forensic scientists, medical practitioners, educators and law enforcement personnel.Table of Contents1 Initial response at crime scenes and prioritization of efforts.- 2 Crime scene processing: documentation and evaluation.- 3 Crime Scene Searching: An Exploration of Forensic Evidence.- 4 Collection, Preservation and Packaging: Forensic Evidence Management.- 5 Paint, Soil and Glass Evidences: A Silent Witnesses.- 6 Questioned Document Examination: A Prevalent Dispute.- 7 Medicolegal Examination: A Guide to the Criminal Investigation System.- 8 Examination of Tampered Voice.

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Book SynopsisGene therapy has been regarded as a great potential for specific treatment of gene-related human diseases, such as cancer, genetic and epidemic diseases. Gene therapy refers to the biomedical technology that inserts normal or therapeutic exogenous genes into target cells to repair or replace defective genes in target cells, so as to achieve the purpose of treating diseases. Efficient gene delivery systems are the crucial roles for successful implementation of gene therapy. This book provides a platform for young scholars and students to systematically understand the preparation and characterization of the existing non-viral gene delivery systems, as well as providing a technology platform for clinical gene therapyTable of ContentsOverview on gene therapy.- Cationic liposome.- Functionalized peptide dendrimers.- Bioresponsive poly(amido amine)s.- Cationic polyphosphoesters.- Polysaccharide-based gene carriers.- Polypeptide-based gene carriers.- Fluorinated gene carriers.- Target gene delivery systems.- Cationic helical polypeptides.- Cyclic cationic polymers.- Cationic bolaamphiphile.- Chitosan-functionalized gene carriers.- Charge-reversal gene carriers.- Multifunctional envelope-type nanodevice.- Drug and gene co-delivery systems.- Oral delivery of gene therapy.- Gene therapy for brain diseases.

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Book SynopsisThis book comprises select papers presented at the conference on Technology Innovation in Mechanical Engineering (TIME-2021). The book discusses the latest innovation and advanced research in the diverse field of Mechanical Engineering such as materials, manufacturing processes, evaluation of materials properties for the application in automotive, aerospace, marine, locomotive and energy sectors. The topics covered include advanced metal forming, Energy Efficient systems, Material Characterization, Advanced metal forming, bending, welding & casting techniques, Composite and Polymer Manufacturing, Intermetallics, Future generation materials, Laser Based Manufacturing, High-Energy Beam Processing, Nano materials, Smart Material, Super Alloys, Powder Metallurgy and Ceramic Forming, Aerodynamics, Biological Heat & Mass Transfer, Combustion & Propulsion, Cryogenics, Fire Dynamics, Refrigeration & Air Conditioning, Sensors and Transducers, Turbulent Flows, Reactive Flows, Numerical Heat Transfer, Phase Change Materials, Micro- and Nano-scale Transport, Multi-phase Flows, Nuclear & Space Applications, Flexible Manufacturing Technology & System, Non-Traditional Machining processes, Structural Strength and Robustness, Vibration, Noise Analysis and Control, Tribology. In addition, it discusses industrial applications and cover theoretical and analytical methods, numerical simulations and experimental techniques in the area of Mechanical Engineering. The book will be helpful for academics, including graduate students and researchers, as well as professionals interested in interdisciplinary topics in the areas of materials, manufacturing, and energy sectors.Table of ContentsBeacon Based Smart Shopping System Using IoT.- Cache Memory Design Analysis for Single Bit Architecture for Core Processor.- Impact of Acoustics Impingement on Proliferating Fires.- Analytical Study of Fluid Pressure Sensing Mechanism in Microchannel for Microfluidic Device.

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Book SynopsisThis book presents recent advances in nanostructured biomaterials. It covers the structures and applications of advanced nanostructured biomaterials. The topics covered include overview on biological activities of thiazole derivatives, imidazole derivatives, pyrazole derivatives, tetrazole derivatives, benzimidazole derivatives, oxazole, isoxazoles, etc. The book also covers the topic of nanocarriers as drug delivery vectors. Given the contents, the book will be useful for students, researchers and professionals working in the area of biomaterials and nanomaterials.Table of ContentsChapter 1 Brief history, pathophysiology, transmission of SARS-CoV-2 virus, and recent advances on transition metal complexes and nanocomposites as the potent antiviral agents from COVID-19 perspectivesChapter 2 Nanocarriers as Drug Delivery VectorsChapter 3 Cocrystals and their induced activity of drugsChapter 4 An Introduction on Evolution of Azole Derivatives in Medicinal ChemistryChapter 5 Overview on Biological Activities of Thiazole DerivativesChapter 6 Overview on Biological Activities of Imidazole DerivativesChapter 7 Overview on Biological Activities of Pyrazole DerivativesChapter 8 An Overview on Biological Evaluation of Tetrazole DerivativesChapter 9 An Overview on Biological Activity of Benzimidazole DerivativesChapter 10 An overview on Biological Activities of Oxazole, Isoxazoles and 1,2,4-oxadiazoles DerivativesChapter 11 An Overview on Biological Activities of 1,2,3-Triazole Derivatives

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Book SynopsisThis book describes the author’s work on the development of sequence-specific DNA binders for the therapy of mitochondrial diseases. In the first chapter, the author provides a detailed background of pyrrole–imidazole polyamides (PIPs) and mitochondrial disease research followed by chapters presenting the author's own research and discoveries. Firstly, the developed compounds called MITO-PIPs, which recognize specific sequences in mitochondrial DNA, are presented. The following chapter demonstrates how, by introducing a DNA alkylating reagent into a MITO-PIP that recognizes the adjacent sequence to a target mutation, the copy number of mutated mitochondrial DNA was successfully reduced in live cells. Furthermore, because nuclear DNA is another important target for treating mitochondrial diseases, the author demonstrated that tri-arginine vectors can enhance nuclear uptake of PIPs and improve their biological activity in cells.This work will attract readers’ interest because it paves the way for a transgene-free chemical gene therapy for mitochondrial diseases. The book includes a detailed description of experimental procedures, especially compound synthesis. This description helps readers to have a clear image of the author’s studies and to perform similar and extended studies themselves.Table of ContentsGeneral Introduction.- Creation of Synthetic Ligand for Mitochondrial DNA sequence Recognition and Promoter-Specific Transcription Suppression.- Allele-Specific Replication Inhibition of Mitochondrial DNA by MITO-PIP Conjugated with Alkylation Reagent.- Enhanced Nuclear Accumulation of Pyrrole–Imidazole Polyamides by Incorporation of the Tri-arginine Vector.

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Book Synopsis This book on biopolymers offers a comprehensive source for biomaterial professionals. It covers all elementary topics related to the properties of biopolymers, the production, and processing of biopolymers, applications of biopolymers, examples of biopolymers, and the future of biopolymers. Edited by experts in the field, the book highlights international professionals’ longstanding experiences and addresses the requirements of practitioners and newcomers in this field in finding a solution to their problems. The book brings together several natural polymers, their extraction/production, and physio-chemical features. The topics covered in this book are biopolymers from renewable sources, marine prokaryotes, soy protein and humus oils, biopolymer recycling, chemical modifications, and specific properties. The book also focuses on the potential and diverse applications of biogenic and bio-derived polymers. The content includes industrial applications of natural polymeric molecules and applications in key areas such as material, biomedical, sensing, packaging, biomedicine, and biotechnology, and tissue engineering applications are discussed in detail. The objective of this book is to fill the gap between the researchers working in the laboratory to cutting-edge technological applications in related industries. This book will be a very valuable reference material for graduates and post-graduate students, academic researchers, professionals, research scholars, and scientists, and for anyone who has a flavor for doing biomaterial research. The books are designed to serve as a bridge between undergraduate textbooks in biochemistry and professional literature. The book provides universal perspectives for an emerging field where classical polymer science blends with molecular biology with highlights on recent advances. Table of ContentsBiopolymers: State of the art and new challengesBiopolymers from renewable sources Recent approaches towards Bacterial NanoCellulose (BNS) synthesis Bacterial nanocellulose from agro-industrial wastes Biopolymers from marine prokaryotes Biomolecules from humus oil Soy protein biopolymer Piezoelectric Properties of Biopolymers Optical properties of biopolymers: Theoretical and experimental advancesMechanical properties of biopolymers Thermal properties of biopolymers Gas barrier properties of biopolymers Structural, morphological and textural properties of biopolymers Tuning the hydrophilic/hydrophobic behavior of biopolymers: Surface modificationsBiopolymer based blends Biopolymer Based Interpenetrating Polymer Networks Biopolymer based gels Biopolymer based composites Biopolymer based nanocomposites Biopolymer based blend nanocomposites Nanofibres and Nanomembranes of biopolymers Biopolymer Based Soil Treatment for Geotechnical Engineering Applications Biopolymers as Engineering Materials Biopolymer based nanocomposites for the treatment of organic pollutants from the synthetic wastewater: ApplicationBio-Medical Applications of Chitin Sustainable biodegradation and extraction of keratin with its applications Material applications of gelatin Natural rubber and guttapercha rubber: ApplicationsAlbumin Engineering applicationsTunable biopolymers Biomedical applicationsNanocellulose from cladophoro ApplicationsCellulose nanocrystals(CNCs)supported inorganic nanomaterials for catalytic applications Bacterial nanocellulose (BNCs) supported inorganic nanomaterials for catalytic applications Bio-compatibility of nanocellulose: Emerging biomedical applicationsSensing and biosensing applications of nanocellulose Packaging Applications of Biodegradable Nanocellulose Composites Nanocellulose based (bio)composites for optoelectronic applications Biopolymers for edible films and coatings in food applications Peptide-based biopolymers in biomedicine and biotechnology Cross-linking biopolymers for biomedical application Natural fibre reinforced biopolymers as construction materials Polylactic acid (PLA): ApplicationsBiopolymer films and composite coatings: ApplicationsGas barrier properties and applications of nanocellulose based materials Applications of Biopolymer-Based Nanofibers and Nanomembranes Amylose-Amylopectin ratio: comprehensive understanding of structure, physico-chemical attributes and applications of starchBiopolymers: Building blocks for the synthesis of advanced materials Nature Inspired Biomimetic Polymeric Materials and Its Applications Cosmetic applications of albumin Biodegradation of Biopolymers:Reflections Towards Possible Biomagnification Definitions and AssessmentBiopolymer waste management: Reuse, Recycling and disposalSafety issues, environmental impacts and health effects of biopolymers Challenges and issues in biopolymer applications

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Book SynopsisThis book presents the advancement of coating materials technology especially in agriculture, particularly for fertilizers. Fertilizers are a critical component in meeting rising demands and ensuring global food security. A new generation of fertilizers made by coating granules with biopolymers address these issues. Coating in agriculture is an important area in research for a more sustainable future. Many examples and instances from existing research and related research gaps are discussed. It includes applications of composites as fertilizer’s coating, advantages and disadvantages of fertilizer coating from composites, applications of bacteria in composite, applications of bacteria in fertilizer industry as well as the common techniques of coating fertilizers with drying process. ​Table of ContentsChapter 1. Introduction to Bio-coating.- Chapter 2. Bio-coating from Composite Materials.- Chapter 3. Bacteria in Bio-coating.- Chapter 4. Evaluation of Bio-coating.- Chapter 5. Techniques of Bio-coating Evaluation.- Chapter 6. Conclusion.-References ​

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Book SynopsisThis book presents high-quality peer-reviewed articles from the 2nd International Conference on Biomass Utilization and Sustainable Energy 2022 (ICoBiomasSE 2022) organized by the Centre of Excellence for Biomass Utilization (COEBU), Universiti Malaysia Perlis (UniMAP), Malaysia. The theme of the conference “Emerging Technology for Future Sustainability” is chosen in view of the current revolution and rapid developments in the field of biomass innovation towards sustainable development. The contents are broadly divided into five parts: (1) sustainable biomass resources for decarbonizing the economy, (2) biomass conversion technologies for bioenergy and biofuels, (3) biomass conversion to intermediates and products, (4) bioeconomy sustainability, impacts and policies and (5) bioenergy integration. It provides a platform for students, professionals, researchers, academicians, policymakers and industries working in the areas of biomass utilization and sustainable energy to solve long-standing environmental issues for a healthier planet.​Table of ContentsPhytoremediation Potential of Salvinia molesta to Reduce Ni and Cd from Simulated Wastewater.- Soil Risk Assessment on the Usage of Molasses-Based Distillery Effluent for Paddy Irrigation: Heavy Metals Content.- Effects of Soil Conditioners on Rice Growth and Soil Properties under Water Stress at Vegetative Stage.- Soil Amelioration Effects on Morphology Traits of Upland Rice Root-Shoot and Soil Productivity under Water Deficit.- Comparison of Corn and Tapioca Starch Binders on the Characteristic of Rice Straw Charcoal Briquettes.- Pretreatment of Leucaena leucocephala Using Deep Eutectic Solvent for Ethanol Production by Kluyveromyces marxianus UniMAP 1-1.- Deep Eutectic Solvent Pretreatment of Rubber Seed Shells for Cellulose and Hemicellulose Production.- Inhibition Study on the Growth of Clostridium Saccharoperbutylacetonicum N1-4 (ATCC 13564) For the Production Biobutanol in ABE Fermentation.- Thermogravimetric Analysis on Empty Fruit Bunch, Rice Husk, and Rice Straw for Feedstock in Biomass Gasification.- A Review on Enhancement of Oil Palm Solid Waste through Torrefaction.- Energy Efficiency of Briquettes from Queen Pineapple (Ananas comosus [Linn.] Merr.) Wastes Using Three Organic Binders.- Optimization of Biobutanol Production from Detoxified Palm Kernel Cake Hydrolysate by Clostridium Acetobutylicum YM1.- Mixed Matrix Membrane (MMMs) as Membrane Based Separation Technology: A Review.- Application of Machine Learning for Biogas Production from Lignocellulosic Biomass.- Utilization of Spent Coffee Ground As Adsorbent for Nitrate Removal.- Nitrate Adsorption using Spent Coffee Ground: Kinetics, Isotherm, and Thermodynamic Studies.- Impact of Power Supply on Electro-Precipitation of Nickel Hydroxide from Industrial Electronic Waste.- Optimization of Nickel Electrowinning from Simulated Watts Bath of Electronics Industrial Waste.- Bio-based Packaging Materials for Fruit and Vegetables - Current Applications and Future Trends: A Review.- Deep Eutectic Solvent-Assisted Synthesis of Nanocrystalline Cellulose Adsorbent for Silver Nitrate Removal.- Optimization of an Ultrasound-Assisted Extraction Method for Phenolic Content in Momordica Charantia Seeds and it’s Antifungal Activity Against Pleurotus ostreatus Green Mould Pathogen.- Optimization of Rice Bran Protein Extraction Using Choline Chloride-Glycerol Deep Eutectic Solvent Using Response Surface Methodology (RSM).- Traditional Paddy Farmers Perception on Bioeconomy Social Change on Adapting Internet of Things in Precision Farming.- Bioeconomy of Local Soybean Farming to Increasing Commodity Competitiveness.- Microbial Fuel Cell: Simultaneous Bioremediation and Energy Recovery Technology.- Green Renewable Energy: Microbial Fuel Cell Technology.

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Book SynopsisThis book presents the selected papers presented at the Third International Congress of Applied Chemistry & Environment (ICACE–3) that took place on May 27-29, 2022. The topics of the conference covers topics from the thematic sections: (1) Environment and Climate Change; (2) Green Chemistry and Natural Substances; (3) Biobased Materials and Nanomaterials; (4) Sustainable Textiles and Clean Processes. For this edition of the conference, it is devoted to present the advantage to use annual plants and/or lignocellulose material as sources for production of fibers and/or cellulose derivatives and/or nanocellulose material with focus on their processing, properties and applications. This book benefits lecturers, students, researchers and industrialists who are working in the field of natural fiber especially in order to preserve the forest resource and to satisfy the increasing demand in pulps.Table of ContentsAntibacterial activity of polyamide and high-density polyethylene nets grafted with polyethylene glycol.- Ecofriendly Extraction of Natural Dye From Waste of Cucurbita Pepo Using Assisted Microwave Method.- Adsorption studies of atrazine herbicide from aqueous solutions using Typha australis as an inexpensive adsorbent: A preliminary investigation.- Use of nanofluid to improve the efficiency of photovoltaic panel.- Kinetic study of dyeing (PET/PTT) bicomponent polyester textiles using ecofriendly carriers.- Preliminary Physicochemical and Phytochemical Study of Seeds of Ziziph us mauritiana.- Effect of some parameters on the efficiency of solar distiller.- Reuse of grain waste as abrasive particles.- Tear strength properties of recycled denim fabrics under mixed washing using Smart Foam technology.- Study of Solar Heating process of Greenhouse in the Gabès Region.- Ergonomic study and work transformation in a clothing industry.

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Book SynopsisThis book gives an overview of the processing, properties, and applications of fibers and cellulose derivatives obtained from annual plant materials in the formation of non-wood source of pulp. The book comprises illustrations and tables summarizing the latest research on the production of fibers and cellulose derivatives using several key methods and/or characterization techniques. This book collates the information and knowledge of new ways to prepare cellulosic derivatives and describe the concepts and architecture of fibers obtained from annual plants. This book caters to researchers, policymakers, and industrial practitioners who are interested in natural fibers as a way to preserve the forest resource and to satisfy the increasing demand in pulps. Table of Contents1. Characterization and comparative evaluation of structural, chemical, thermal, mechanical, and morphological properties of plant fibers2. Characterization and comparative evaluation of thermal, structural, chemical, mechanical and morphological properties3. Recent developments in pretreatment strategies on annual plant residues for bioethanol production: Technological progress and challenges4. Production of cellulose nanocrystal from date palm and their comparison with others sources5. Preparation and characterization of cellulose nanofibril from annual plant6. Characterization of nanocellulose obtained from cactus7. Corn crop residues as source to obtain cellulose nanocrystals8. Recent nanocelullose applications for sustainable agriculture – A review9. Alternative adhesives for composites made of annual plants10. Annual Plant Reinforced Biocomposite Fiberboards – Investigation on Mechanical Properties11. Nanocomposites with cellulose nanocrystals extracted from annual plants12. Advances in the production of cellulose nanomaterials and their use in engineering (bio)plastics13. An overview on the pharmaceutical applications of nanocellulose14. Preparation and characterization of cellulosic derivatives from annual plant15. Structure and properties of cellulose and its derivatives16. Activated Carbon from agricultural waste for the removal of pollutants from aqueous solution17. Valorization of annual plants in removing synthetic dyes18. Schinus molle: Currently status and opportunity

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