Description
Book SynopsisThis volume focuses on the biomedical aspects of inorganic polyphosphates, a family of unique bio-inorganic polymers.
In recent years, great advances have been made in understanding the development, metabolism, and physiological role of inorganic polyphosphates. These energy-rich polymers, which consist of long chains of phosphate units, are evolutionary old molecules. The acidocalcisomes, conserved organelles from bacteria to humans, as well as the mitochondria play a central role in polyphosphate production and storage. Polyphosphates have been assigned multiple functions, some of which are closely related to medically important processes, such as blood coagulation and fibrinolysis, energy metabolism, cell cycle regulation, apoptosis, chaperon function, microvascularization, stress response, neurodegeneration and aging. The development of bioinspired polyphosphate particles, in combination with suitable hydrogel-forming polymers enabled the development of new strategies in regenerative medicine, in particular for hard and soft tissue repair, but also in drug delivery and antimicrobial defense.
This book not only highlights the basic research in this area, but also discusses possible applications. Therefore, it appeals to scientists working in cell biology, biochemistry, and biomedicine and practicioners alike.
Table of Contents1. Mitochondrial polyP production
Prof. Dr. Andrey Y. Abramov, University College London, London, UK
a.abramov@ucl.ac.uk
2. Polyphosphate in thrombosis and inflammation
Prof. Dr. James H. Morrissey and Dr. Stephanie Smith, University of Michigan Medical School, Ann Arbor MI, USA
jim@tf7.org or jhmorris@umich.edu
3. Polyphosphate in mitochondrial energy metabolism and pathology
Prof. Dr. Evgeny Pavlov, NYU College of Dentistry, New York NY, USA
ep37@nyu.edu
4. Polyphosphate in plasma and human pathologies
Prof. Dr. Felix Ruiz, Facultad de Medicina, Universidad de Cádiz, Cádiz, Spain
felix.ruiz@uca.es
5. PolyP in neurodegeneration and aging
Prof. Dr. Maria E. Solesio, Rutgers University, Camden NJ, USA
m.solesio@rutgers.edu
6. Effects of polyphosphate on function of leukocytes
Dr. Patrick Suess, University of Michigan Medical School, Ann Arbor MI, USA
psuess@med.umich.edu
7. PolyP and Vtc complex
Prof. Dr. Andreas Mayer, University of Lausanne, Epalinges, Switzerland
andreas.mayer@unil.ch
8. PolyP in antiviral protection
Prof. Dr. Dr. h.c. Werner E. G. Müller, Prof. Dr. Xiaohong Wang, Prof. Dr. Dr. Heinz C. Schröder, University Medical Center of Johannes Gutenberg University Mainz
wmueller@uni-mainz.de
9. Polyphosphate in biomimetic implant materials
Prof. Dr. Dr. Heinz C. Schröder, Prof. Dr. Xiaohong Wang, Prof. Dr. Dr. h.c. Werner E. G. Müller, University Medical Center of Johannes Gutenberg University Mainz
wmueller@uni-mainz.de
