Biophysics Books
IOP Publishing SOME CRITICAL QUESTIONS BIOLOGICAL PHYPB
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£999.99
Institute of Physics Publishing Calcium Signals
Book SynopsisThis book discusses the cellular and molecular basisfor the regulation of calcium changes in cells and, in turn, the impact ofchanges in cell calcium on physiological function.
£108.00
IOP Publishing Calcium Signals
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£23.75
IOP Publishing Physics of Cancer 2nd Edition Volume 1 Interplay
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£23.75
Institute of Physics Publishing Modeling and Simulating Cardiac Electrical
Book SynopsisThisbook provides a thorough introduction to the topic of mathematical modeling ofelectrical activity in the heart, from molecular details of ionic channeldynamics to clinically derived patient-specific models.
£108.00
Institute of Physics Publishing An Introduction to Fluorescence Correlation
Book SynopsisAn Introduction to Fluorescence Correlation Spectroscopy represents a comprehensive introduction to fluorescence correlation spectroscopy (FCS), a biophysical experimental technique increasingly used to study and quantify molecular mobility, concentrations and interactions in vitro, as well as in living cells and multicellular organisms. Students and researchers who are new to FCS can use the book as the first introduction to the technique, while those who are already using FCS regularly in their research may find it useful to deepen their understanding of the technique, its possibilities, limitations, and potential pitfalls as well as ways to avoid them. This book introduces the reader to all aspects of FCS needed for practical usage of the technique in their research. In the beginning the concept of fluorescence intensity fluctuations and their auto- and cross-correlation functions are explained to give readers an understanding of
£108.00
Institute of Physics Publishing Biophysical and Chemical Properties of Collagen
Book SynopsisBiophysical and Chemical Properties of Collagen: Biomedical Applications provides an introduction to the biophysics and chemistry of collagen and its use as a biomedical material in the rapidly changing fields of biomedical device production, tissue engineering and regenerative medicine. Written by experts in the field, this text will be of interest for researchers as well as lecturers and students.
£108.00
IOP Publishing Physics of Cancer 2nd Edition Volume 2 Cellular
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£23.75
Institute of Physics Publishing Principles of ProteinProtein Association
Book SynopsisAnyoneteaching physical biochemistry or structural biology will find this to be aconcise and thorough guide for their lectures on protein-protein association.Students and researchers will appreciate the clarity of presentation offundamental concepts, and the guided reading of informative classic papers.
£89.10
IOP Publishing Ltd Principles of ProteinProtein Association
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£23.75
Institute of Physics Publishing Ecological Modelling and Ecophysics
Book SynopsisThis book focuses on use-inspired basic science by connecting theoretical methods and mathematical developments in ecology with practical real-world problems, either in production or conservation. The text aims to increase the reader’s confidence to rely on partial aspects and relations of systems to which we only have an incomplete understanding. By abstracting and simplifying problems, Ecological Modelling and Ecophysics seeks to expand the reader’s understanding and ability to solve practical issues with rigorous quantitative methods.The first part of this book is devoted to classical methods in population and community ecology. The second part aims to introduce the reader to certain tools and techniques from different branches of physics, such as thermodynamics, statistical mechanics and complex systems, and their applications in ecology and environmental sciences. Connecting ecological problems with well-studied phenomena in physics allows the exploiting of analogies to gain deeper insight into these problems, to identify novel questions and problems, and to get access to alternative quantitative methods and tools from physics. This is an essential text for quantitative ecologists and environmental scientists with an interest in novel mathematical approaches, and also applied physicists and mathematicians with an interest in ecological systems.Key Features Focuses on the practical applications of quantitative ecological models Practical challenges are drawn from agriculture and environmental science Applies methods and theories from physics to gain deeper insight into ecological challenges Covers key quantitative models in ecology including niche theory, mutualism, and game theory Will be of interest to environmental scientists and biophysicists as well as ecologists
£108.00
IOP Publishing ECOLOGICAL MODELLING AND ECOPHYSICS PB
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£23.75
Institute of Physics Publishing SolidState NMR
Book SynopsisThis book describes the methodology and applications of solid-state NMR spectroscopy to studies of membrane proteins, membrane-active peptides and model biological membranes. As well as structural studies it contains coverage of membrane interactions and molecular motions. Advances in biological solid-state NMR are very pertinent with high-field developments seeing applications in biological membranes and whole cells. Many of the chapter authors and contributors are world-class experts and leaders in the development and application of biological solid-state NMR. Key Features Addresses principles, methods and applications of solid-state NMR methods to biomembrane studies Introduction to biological solid-state NMR and applications to biological membranes Structure and dynamics of membrane lipids, proteins and peptides NMR studies of membrane interactions and molecular motion
£108.00
IOP Publishing SolidState NMR
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£23.75
IOP Publishing MULTISCALE MODELING VASCULAR DYNAMICS PB
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£23.75
IOP Publishing Smart External StimulusResponsive Nanocarriers
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£42.26
IOP Publishing Smart Internal StimulusResponsive Nanocarriers
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£42.26
IOP Publishing Biophotonics Vibrational Spectroscopic
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£37.76
IOP Publishing Physical Microbe
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£42.26
IOP Publishing Electronic Structure of Organic Semiconductors
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£51.75
IOP Publishing Science in the Arena
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£34.67
IOP Publishing Introduction to Nanomaterials in Medicine
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£47.25
IOP Publishing Introduction to Cellular Biophysics Volume 1
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£37.76
IOP Publishing StimuliResponsive Polymers
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£34.67
Institute of Physics Publishing Singleparticle CryoEM of Biological
Book SynopsisThis edited book is written for students, postdocs and established investigators who want to enter the field of single-particle cryo-EM. This is a recently developed method to determine high-resolution structures of biological macromolecules. A major strength is the fact that cryo-EM does not require prior crystallization of protein complexes. It is especially well suited for larger complexes and molecular machines. This book, provides a comprehensive, accessible and authoritative introduction to the field. It covers all necessary background, ranging from the underlying concepts to practical aspects such as specimen preparation, data-collection, data analysis, and the final validation of results.Key features Written for students, postdocs and established investigators who want to enter the field of single-particle cryo-EM Provides a comprehensive, accessible and authoritative introduction to the field of high-resolutio
£108.00
IOP Publishing Singleparticle CryoEM of Biological
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£23.75
IOP Publishing Physics of Cancer Volume 3 Second Edition
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£23.75
IOP Publishing The Everyday Physics of Hearing and Vision Second
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£23.75
IOP Publishing Optical Evanescence Microscopy TIRF
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£23.75
Institute of Physics Publishing The BrainBladder Axis in Tissue Growth and
Book SynopsisApplying the general deterministic approach of systems computational biology, the monograph considers questions related to the biomechanics of the human urinary bladder in conjunction with the peripheral and central nervous systems. The step-by-step development of mathematical models of separate structural elements and their assembly into a unique self-regulatory system offers, for the first time, a holistic overview and allows the investigation of the dynamics of the lower urinary tract system at its hierarchical levels. This book provides a coherent description and explanation for intertwined intracellular pathways in terms of spatiotemporal, whole body, tractable representations which are supported by numerous computational simulations.Key FeaturesIt reconstructs accurately the cytoarchitecture and morphofunctional relationships between the elements of the central nervous (brain) and genitourinary (urinary bladder s
£108.00
Institute of Physics Publishing Protein and Peptidebased Microarrays for
Book SynopsisThis book discusses the aspects of protein and peptide-based microarrays for multiplex detection, based on Rabiee''s Theory. It provides a thorough introduction to the field, before examining protein and peptide-based microarrays in greater detail, along with their related problems and solutions. Also covered are the materials and fabrication methods involved with protein microarrays. It offers an outlook on the future of the field within its conclusion and provides an understanding of cutting-edge aspects and horizons of this topic and is an excellent guide for scientists, students and doctors.Key Features Comprehensive coverage of protein and peptide-based microarrays for multiplex detection Cutting-edge guide to the field An excellent resource for scientists, students and doctors
£108.00
IOP Publishing Protein and Peptidebased Microarrays for
Book Synopsis
£23.75
Institute of Physics Publishing Humanitarian Engineering for Global Oncology
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£108.00
IOP Publishing Ltd Humanitarian Engineering for Global Oncology
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£23.75
Institute of Physics Publishing Simulation of Complex Systems
Book SynopsisUltra-BriefThis book provides the most fundamental and essentialtechniques to simulate complex systems, from the dynamics of molecules to thespreading of diseases, from optimization using ant colonies to the simulationof the Game of Life.
£67.50
IOP Publishing Physics of Cancer Second Edition Volume 4
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£23.75
IOP Publishing Physics of Cancer Second Edition Volume 6
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£23.75
Institute of Physics Publishing Cold Atmospheric Plasmabased Cancer Therapy
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£108.00
Taylor & Francis Inc Physical Biology of the Cell
Book SynopsisPhysical Biology of the Cell is a textbook for a first course in physical biology or biophysics for undergraduate or graduate students. It maps the huge and complex landscape of cell and molecular biology from the distinct perspective of physical biology. As a key organizing principle, the proximity of topics is based on the physical concepts that unite a given set of biological phenomena. Herein lies the central premise: that the appropriate application of a few fundamental physical models can serve as the foundation of whole bodies of quantitative biological intuition, useful across a wide range of biological problems. The Second Edition features full-color illustrations throughout, two new chapters, a significantly expanded set of end-of-chapter problems, and is available in a variety of e-book formats.Trade Review“The book is well illustrated, problems and references complete each chapter, figures and other data can be downloaded from the Garland Science Web site. Its public is assumed to be students taking a first course in physical biology or biophysics, and scientists interested in physical modelling in biology. Physical Biology of the Cell has much to offer to both categories…”- Crystallography Reviews“This textbook is an excellent resource, both for a research scientist and for a teacher. The authors do a superb job of selecting the material for each chapter and explaining the material with equations and narrative in an easily digestible manner.”—Yale Journal of Biology and Medicine (YJBM)Praise for the First Edition of Physical Biology of the Cell“Physical Biology of the Cell…aims to be both an introduction to molecular and cellular biology for physicists and an introduction to physics for biologists. Though that sounds like a daunting task, the book fully and impressively delivers. Physical Biology of the Cell might well become a similar classic [as Molecular Biology of the Cell] for anyone who heeds its mantra “quantitative data demand quantitative models.” It will give both physicists and biologists a useful introduction into the other camp’s methods and ways of thinking.”—Ralf Bundschuh, Physics Today, 2009“[The] authors of Physical Biology of the Cell have produced one of the first multi-purpose textbooks that is readily accessible to both physicists and biologists….When read from cover to cover, the book is both very instructive and highly entertaining, with the authors using humor to deliver strong take-home messages in each chapter....Physical Biology of the Cell provides instructors with excellent material to create a graduate level course in biology or physics.”—Patricia Bassereau and Pierre Nasoy, Nature Cell Biology, 2009“Physical Biology of the Cell is beautifully crafted: self-contained and modular, it provides tutorials on fundamentals and has material to hold the interest of a more sophisticated reader. It is fast-paced, proceeding within each chapter from freshman basics to graduate level sophistication. To truly master the physics presented in thebook, one should do the problems provided with each chapter. These problems are well thought out and are a major teaching resource.”—Boris Shraiman, Cell, 2009“…a monumental undertaking by three outstanding experts in the field…the book is a rich collection of special topics in biophysics…”—Gabor Forgacs, Quarterly Review of Biology, 2009“I would thoroughly recommend [Physical Biology of the Cell] to anyone interested in investigating or applying biophysical research methods to their work. It is likely to be a fantastic teaching tool and is a welcome addition in this age of increasinglyinterdisciplinary science.”—David Stephens, The British Society for Cell Biology Newsletter, 2009“The book is well illustrated, problems and references complete each chapter, figures and other data can be downloaded from the Garland Science Web site. Its public is assumed to be students taking a first course in physical biology or biophysics, and scientists interested in physical modelling in biology. Physical Biology of the Cell has much to offer to both categories…”- Crystallography Reviews“This textbook is an excellent resource, both for a research scientist and for a teacher. The authors do a superb job of selecting the material for each chapter and explaining the material with equations and narrative in an easily digestible manner.”—Yale Journal of Biology and Medicine (YJBM)Praise for the First Edition of Physical Biology of the Cell: “Physical Biology of the Cell…aims to be both an introduction to molecular and cellular biology for physicists and an introduction to physics for biologists. Though that sounds like a daunting task, the book fully and impressively delivers. Physical Biology of the Cell might well become a similar classic [as Molecular Biology of the Cell] for anyone who heeds its mantra “quantitative data demand quantitative models.” It will give both physicists and biologists a useful introduction into the other camp’s methods and ways of thinking.”—Ralf Bundschuh, Physics Today, 2009“[The] authors of Physical Biology of the Cell have produced one of the first multi-purpose textbooks that is readily accessible to both physicists and biologists….When read from cover to cover, the book is both very instructive and highly entertaining, with the authors using humor to deliver strong take-home messages in each chapter....Physical Biology of the Cell provides instructors with excellent material to create a graduate level course in biology or physics.”—Patricia Bassereau and Pierre Nasoy, Nature Cell Biology, 2009“Physical Biology of the Cell is beautifully crafted: self-contained and modular, it provides tutorials on fundamentals and has material to hold the interest of a more sophisticated reader. It is fast-paced, proceeding within each chapter from freshman basics to graduate level sophistication. To truly master the physics presented in thebook, one should do the problems provided with each chapter. These problems are well thought out and are a major teaching resource.”—Boris Shraiman, Cell, 2009“…a monumental undertaking by three outstanding experts in the field…the book is a rich collection of special topics in biophysics…”—Gabor Forgacs, Quarterly Review of Biology, 2009“I would thoroughly recommend [Physical Biology of the Cell] to anyone interested in investigating or applying biophysical research methods to their work. It is likely to be a fantastic teaching tool and is a welcome addition in this age of increasinglyinterdisciplinary science.”—David Stephens, The British Society for Cell Biology Newsletter, 2009Table of ContentsPart I: The Facts of Life1. Why: Biology by the Numbers 2. What and Where 3. When: Stopwatches at Many Scales 4. Who: "Bless the Little Beasties"Part II: Life at Rest5. Mechanical and Chemical Equilibrium 6. Entropy Rules! 7. Two-State Systems 8. Random Walks and the Structure of Macromolecules 9. Electrostatics for Salty Solutions 10. Beam Theory 11. Biological MembranesPart III: Life in Motion12. The Mathematics of Water 13. A Statistical View of Biological Dynamics14. Crowded and Disordered Environments 15. Rate Equations and Dynamics in the Cell 16. Dynamics of Molecular Motors 17. Biological Electricity 18. Light and Life – NEW CHAPTERPart IV: The Meaning of Life19. Organization of Biological Networks20. Biological Patterns: Order in Space and Time – NEW CHAPTER21. Sequences, Specificity, and Evolution 22. Whither Physical Biology?
£87.39
Taylor & Francis Inc NanoBioMaterials
Book SynopsisThe present book volume presents a holistic view of the aspects of nanobiomaterials incl. their stellar merits and limitations, applications in diverse fields, their futuristic promise in the fields of biomedical science and drug delivery. The federal & regulatory issues on the usage of nanobiomaterials have been assigned due consideration.Table of ContentsApplications of Nano-Based Biomaterials. Nanocoutured Metallic Biomaterials and Surface Functionalization of Titanium-based Alloys for Medical Applications. Graphene-Polymer Nanocomposites for Biomedical Applications. Lipid-based Nanocarriers in Lymphatic Transport of Drugs: Retrospect and Prospects. Nanotechnology in Early Diagnosis of Cancer. Dendrimers: Emerging Anti-Infective Nanomedicines. Production and Utilization of Nanofibers. Fibro-Porous Composite Nano-Biomaterials for Enhanced Bio-Integration. Nanocarriers Mediated Protein Delivery. Nanotechnology-Based Prodrug Conjugates for Site-Specific Antineoplastic Therapy. Osteomyelitis: Therapeutic Management using Nanomedicines.Nanostructured Lipid Carriers-Mediated Methotraxate Delivery Evokes Transcription Factors to Induce Selective Apoptosis in Rheumatoid Arthritis.Superparamagnetic Iron Oxide Nanoparticles for Magnetic Hyperthermia Applications. Development of In-house Nano-hydroxyapatite Particles for Dental Applications.
£175.00
Springer Essential Physics Chemistry and Biology Student S
a huge range and FREE tracked UK delivery on ALL orders.
£999.99
Quantometrix, Inc. QuantoGeometry Vol III
£999.99
Springer-Verlag New York Inc. Membrane Lipids
Book SynopsisThis detailed book explores examples of current in vitro and in silico techniques that are at the forefront of lipid membrane research today. Beginning with methods and strategies associated with the creation and use of lipid membrane models in various research settings, the volume continues with electrical impedance spectroscopy strategies and methods to identify how ions and proteins interact with model lipid bilayers, guidance on lipid bilayer in silico molecular dynamics modeling, novel techniques to explore lipid bilayer characteristics using neutron scattering, IR spectroscopy, and atomic force microscopy (AFM), as well as unique fluorescence techniques. Written in the highly successful Methods in Molecular Biology series style, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Table of Contents1. Methods for Forming Giant Unilamellar Fatty Acid Vesicles Lauren A. Lowe, Daniel W.K. Loo, and Anna Wang 2. Preparing Ion Channel Switch Membrane-Based Biosensors Amani Alghalayini, Charles G. Cranfield, Bruce A. Cornell, and Stella M. Valenzuela 3. Langmuir-Schaefer Deposition to Create an Asymmetrical Lipopolysaccharide Sparsely-Tethered Lipid Bilayer Charles G. Cranfield, Anton Le Brun, Alvaro Garcia, Bruce A. Cornell, and Stephen A. Holt 4. Electrochemical Impedance Spectroscopy as a Convenient Tool to Characterize Tethered Bilayer Membranes Tadas Penkauskas, Filipas Ambrulevičius, and Gintaras Valinčius 5. Measuring Voltage-Current Characteristics of Tethered Bilayer Lipid Membranes to Determine the Electro-Insertion Properties of Analytes Hadeel Alobeedallah, Bruce A. Cornell, and Hans Coster 6. Measuring Activation Energies for Ion Transport Using Tethered Bilayer Lipid Membranes (tBLMs) Hadeel Alobeedallah, Bruce A. Cornell, and Hans Coster 7. Determining the Pore Size of Multimeric Peptide Ion Channels Using Cation Conductance Measures of Tethered Bilayer Lipid Membranes Lissy M. Hartmann, Alvaro Garcia, Evelyne Deplazes, and Charles G. Cranfield 8. De-Insertion Current Analysis of Pore-Forming Peptides and Proteins Using Gold Electrode-Supported Lipid Bilayer Kan Shoji 9. Drug Meets Monolayer: Understanding the Interactions of Sterol Drugs with Models of the Lung Surfactant Monolayer Using Molecular Dynamics Simulations Sheikh I. Hossain, Mohammad Z. Islam, Suvash C. Saha, and Evelyne Deplazes 10. Establishing a Lipid Bilayer for Molecular Dynamics Simulations Robby Manrique 11. Initiating Coarse-Grained MD Simulations for Membrane-Bound Proteins Amanda Buyan and Ben Corry 12. Small Angle Neutron Scattering of Liposomes: Sample Preparation to Simple Modeling Kathleen Wood 13. Time-Resolved SANS to Measure Monomer Inter-Bilayer Exchange and Intra-Bilayer Translocation Michael H.L. Nguyen, Mitchell DiPasquale, Stuart R. Castillo, and Drew Marquardt 14. Identifying Membrane Lateral Organization by Contrast-Matched Small Angle Neutron Scattering Mitchell DiPasquale, Michael H.L. Nguyen, Stuart R. Castillo, Frederick A. Heberle, and Drew Marquardt 15. Using refnx to Model Neutron Reflectometry Data from Phospholipid Bilayers Stephen A. Holt, Tara E. Oliver, and Andrew R.J. Nelson 16. Surface-Enhanced Infrared Absorption Spectroscopy (SEIRAS) to Probe Interfacial Water in Floating Bilayer Lipid Membranes (fBLMs) Kinga Burdach, Damian Dziubak, and Slawomir Sek 17. Manipulation of Lipid Membranes with Thermal Stimuli Karolina Spustova, Lin Xue, Ruslan Ryskulov, Aldo Jesorka, and Irep Gözen 18. Analyzing Morphological Properties of Early-Stage Toxic Amyloid β Oligomers by Atomic Force Microscopy Dusan Mrdenovic, Jacek Lipkowski, and Piotr Pieta 19. Formation and Nanoscale Characterization of Asymmetric Supported Lipid Bilayers Containing Raft-Like Domains Romina F. Vázquez, Erasmo Ovalle-García, Armando Antillón, Iván Ortega-Blake, Carlos Muñoz-Garay, and Sabina M. Maté 20. Rapid FLIM Measurement of Membrane Tension Probe Flipper-TR Elvis Pandzic, Renee Whan, and Alex Macmillan 21. Bacterial Dye Release Measures in Response to Antimicrobial Peptides Srikanth Dumpati and Debarun Dutta 22. Quantitative Measurements of Membrane Lipid Order in Yeast and Fungi Maria Makarova and Dylan M. Owen
£999.99
Springer-Verlag New York Inc. TGFBeta Signaling
Book SynopsisThis detailed volume is devoted to the recent development of quantitative experiments and computational methods driving new transforming growth factor beta (TGF-ß) and other cell signaling knowledge.Table of Contents1. Absolute Quantification of TGF-β Signaling Proteins Using Quantitative Western Blot Difan Deng and Zhike Zi 2. Fast Quantitation of TGF-β Signaling Using Adenoviral Reporter Adilson Fonseca Teixeira, Josie Iaria, and Hong-Jian Zhu 3. Complex Formation among TGF-b Receptors in Live Cell Membranes Measured by Patch-FRAP Szabina Szófia Szilágyi, Orit Gutman, and Yoav I. Henis 4. Branched Proximity Hybridization Assay for the Quantification of Nanoscale Protein-Protein Proximity Jianying Yang 5. Visualizing Dynamic Changes during TGF-β-Induced Epithelial to Mesenchymal Transition Abhishek Sinha, Pranav Mehta, Chuannan Fan, Jing Zhang, Dieuwke L. Marvin, Maarten van Dinther, Laila Ritsma, Pouyan E. Boukany, and Peter ten Dijke 6. Establishment of Embryonic Zebrafish Xenograft Assays to Investigate TGF-β Family Signaling in Human Breast Cancer Progression Chao Li, Jin Ma, Arwin Groenewoud, Jiang Ren, Sijia Liu, B. Ewa Snaar-Jagalska, and Peter ten Dijke 7. Generating Somatic Knockout Cell Lines with CRISPR-Cas9 Technology to Investigate SMAD Signaling Zixin Huang and Alexander Loewer 8. CRISPR-Based Screening in Three-Dimensional Organoid Cultures to Identify TGF-β Pathway Regulators Nina Frey and Gerald Schwank 9. Optogenetic Control of TGF-β Signaling Yuchao Li and Zhike Zi 10. Using Microfluidics and Live Cell Reporters to Dissect the Dynamics of TGF-β Signaling in Mouse Embryonic Stem Cells Fabien Furfaro, Carine Vias, and Benoit Sorre 11. Energy Landscape Analysis of the Epithelial-Mesenchymal Transition Network Leijun Ye and Chunhe Li 12. Discrete Logic Modeling of Cell Signaling Pathways Nensi Ikonomi, Silke D. Werle, Julian D. Schwab, and Hans A. Kestler 13. Mining of Single-Cell Signaling Time-Series for Dynamic Phenotypes with Clustering Maciej Dobrzyński, Marc-Antoine Jacques, and Olivier Pertz 14. Automated Classification of Cellular Phenotypes Using Machine Learning in Cellprofiler and CellProfiler Analyst Marja Kornhuber and Sebastian Dunst 15. Live Cell Imaging of Spatiotemporal Ca2+ Fluctuation Responses to Anticancer Drugs Zeyu Liu, Adrian Ramirez, and Xuedong Liu
£999.99
Humana Calcium Signaling
Book SynopsisMeasuring GPCR-Induced Intracellular Calcium Signaling Using a Quantitative High-Throughput Assay.- Quantifying Gq Signaling Using the IP1 Homogenous Time Resolved Fluorescence (HTRF) Assay.- Measuring IP3 Generation in Real-Time Using a NanoBiT Luminescence Biosensor.- Monitoring Calcium-Sensing Receptor (CaSR) Induced Intracellular Calcium Flux Using an Indo-1 Flow Cytometry Assay.- Bioluminescence Resonance Energy Transfer (BRET) Assay to Measure Gq Recruitment to the Ghrelin Receptor.- Analysis of Calcium-Sensing Receptor Signaling Using Dual Luciferase Assays.- Calcium Imaging in Brain Tissue Slices.- Two-Photon Microscopy to Measure Calcium Signaling in the Living Brain.- Measuring Calcium-Sensing Receptor Agonist-Driven Insertional Signaling (ADIS) and Trafficking by TIRF Microscopy.- Measuring Calcium Signaling at the Primary Cilia.- Monitoring ER Ca2+ by Luminescence with Low Affinity GFP-Aequorin Protein (GAP).- Analyzing Mitochondrial Calcium Influx in Isolated Mitochondr
£999.99
Cambridge University Press Cellular Biophysics and Modeling
Book SynopsisAn integrated guide to cellular biophysics and nonlinear dynamics, introducing students to the mathematical modeling of excitable cells. It combines empirical physiology and mathematical theory to present key interdisciplinary tools, highlighting how quantitative approaches can complement and advance bench research.Trade Review'In this text, Conradi Smith does an excellent job of teaching students with no mathematical training beyond calculus how to use differential equations to understand the basic principles of cell physiology and excitability. He skilfully walks students through the steps of modeling and analysis, all the while working to develop intuition and insight into how things work. His emphasis on computational methods for solution as well as graphical and geometrical means for interpretation enables him to communicate complex ideas in understandable ways. Furthermore, his patience and attention to detail will be appreciated by those students who have not had extensive exposure to the art of mathematical modeling. This text is a wonderful addition to the mathematical biology textbook literature.' James P. Keener, University of UtahTable of Contents1. Introduction; Part I. Models and Odes: 2. Compartmental modeling; 3. Phase diagrams; 4. Ligands, receptors and rate laws; 5. Function families and characteristic times; 6. Bifurcation diagrams of scalar ODEs; Part II. Passive Membranes: 7. The Nernst equilibrium potential; 8. The current balance equation; 9. GHK theory of membrane permeation; Part III. Voltage-Gated Currents: 10. Voltage-gated ionic currents; 11. Regenerative ionic currents and bistability; 12. Voltage-clamp recording; 13. Hodgkin-Huxley model of the action potential; Part IV. Excitability and Phase Planes: 14. The Morris-Lecar model; 15. Phase plane analysis; 16. Linear stability analysis; Part V. Oscillations and Bursting: 17. Type II excitability and oscillations; 18. Type I excitability and oscillations; 19. The low-threshold calcium spike; 20. Synaptic currents.
£999.99
Cambridge University Press Why Dna
Book SynopsisInformation is central to the evolution of biological complexity, a physical system relying on a continuous supply of energy. Biology provides superb examples of the consequent Darwinian selection of mechanisms for efficient energy utilisation. Genetic information, underpinned by the Watson-Crick base-pairing rules is largely encoded by DNA, a molecule uniquely adapted to its roles in information storage and utilisation.This volume addresses two fundamental questions. Firstly, what properties of the molecule have enabled it to become the predominant genetic material in the biological world today and secondly, to what extent have the informational properties of the molecule contributed to the expansion of biological diversity and the stability of ecosystems. The author argues that bringing these two seemingly unrelated topics together enables Schrödinger''s What is Life?, published before the structure of DNA was known, to be revisited and his ideas examined in the context of our current biological understanding.Trade Review'The essence of the book is in its title. The DNA structures and topology are described so clearly that the reader perceives these intricacies as pure evolutionary elegance, and understands WHY it is only in its balance of stability and agility that life could have started its journey. This book explains how DNA has become the fascinating prism, made of a fabric of complexity and information, into which the living reflects itself. My opinion is passionate because I have been thinking about the same problems for decades, and here I find many of the answers. Especially: what makes DNA so unique? It is a text that I keep reading over again.' Ernesto Di Mauro, IBPM, National Research Council, Rome'In What Is Life? Schrödinger conjectured that, in animate matter, order is derived from order, foreshadowing the discovery of DNA structure. Why DNA? is about this molecule and its dual information content - in linear genetic code and in thermodynamics of three-dimensional DNA structures. It addresses how DNA's intrinsic order led to complex, highly ordered living organisms, in a world that strives towards disorder. Why would DNA supplant RNA in carrying hereditary information during biological evolution? Why did multicellular organisms emerge, since natural selection favours the fittest, such as simple bacteria? What is complexity, and what has it to do with Bayesian logic? How do complexity, information and energy interrelate? This is a succinct discourse on Schrödinger's question, expanding from molecular interactions and genome cooperation to ecological systems and societal evolution. A must-read for biology scholars, and anyone interested in life's origins, biological evolution and the interface of biology and physics.' Georgi Muskhelishvili, Agricultural University of Georgia, TbilisiTable of ContentsAcknowledgements; Preface; 1. The perennial question; 2. The nature of information – information, complexity and entropy; 3. DNA – the molecule; 4. The evolution of biological complexity; 5. Cooperating genomes; 6. DNA, information and complexity; 7. Origins; 8. The complexity of societies; 9. Why DNA – and not RNA?; General reading and bibliography.
£999.99
Cambridge University Press The Handbook of Medical Image Perception and Techniques
Book SynopsisA state-of-the-art review of key topics in medical image perception science and practice, including associated techniques, illustrations and examples. This second edition contains extensive updates and substantial new content. Written by key figures in the field, it covers a wide range of topics including signal detection, image interpretation and advanced image analysis (e.g. deep learning) techniques for interpretive and computational perception. It provides an overview of the key techniques of medical image perception and observer performance research, and includes examples and applications across clinical disciplines including radiology, pathology and oncology. A final chapter discusses the future prospects of medical image perception and assesses upcoming challenges and possibilities, enabling readers to identify new areas for research. Written for both newcomers to the field and experienced researchers and clinicians, this book provides a comprehensive reference for those interesTrade Review'In The Handbook of Medical Image Perception and Techniques, Samei and Krupinski have assembled a group of internationally-recognized experts to address an important but under-emphasized stage in the process of medical imaging.' William Hendee, Distinguished Professor Emeritus, Medical College of Wisconsin'A concise text that offers a unique collection of chapters from all the leading authors in medical perception. I would highly recommend this text for anyone wanting to know more about medical perception from its historical perspective to current research. A must have reference for anyone wanting to join in this exciting discipline.' Lonie R. Salkowski, University of Wisconsin, Madison'Drs Elizabeth Krupinski and Ehsan Samei have given us a wonderful new edition of their landmark textbook on medical image perception, with updated chapters throughout and with approximately thirty percent new material added since the first edition was published in 2010. This new volume comprehensively updates and extends the 'keystone' publication in the field of medical image perception research. Each chapter is the definitive reference on its topic, authored by a foremost expert. With this new edition, Drs Krupinski and Samei have assembled a compendium of what amounts to decades of research and accumulated wisdom in a compact package-comprehensive and yet still very accessible for a broad audience. … Anyone with an interest in this topic will find this book to be an invaluable resource.' Michael A. Bruno, Pennsylvania State UniversityTable of Contents1. Medical image perception Ehsan Samei and Elizabeth Krupinski; 2. A short history of image perception in medical radiology Harold Kundel and Calvin Nodine; 3. Spatial vision research without noise Arthur Burgess; 4. Signal detection theory – a brief history Arthur Burgess; 5. Signal detection in radiology Arthur Burgess; 6. Lessons from dinners with the giants of modern image science Robert Wagner; 7. Perception in context David Manning; 8. Perceptual factors in reading medical images Elizabeth A Krupinski; 9. Cognitive factors in reading medical images David Manning; 10. Satisfaction of search in radiology Kevib Berbaum, Edmund Franken, Robert Caldwell, Kevin Schartz and Mark Madsen; 11. Acquiring expertise in radiologic image interpretation Calvin F. Nodine and Claudia Mello-Thoms; 12. The first moments of medical image perception Jeremy M. Wolfe, Karla K. Evans and Trafton Drew; 13. Image quality and its clinical relevance Justin Solomon, Robert Saunders, Jr and Ehsan Samei; 14. Designing perception experiments Ehsan Samei; 15. Receiver operating characteristic analysis: basic concepts and practical applications Georgia Tourassi; 16. Multireader ROC analysis Stephen L. Hillis; 17. Memory effects and experimental design Tamara Miner Haygood and Karla K. Evans; 18. Observer models as a surrogate to perception experiments Craig K. Abbey and Miguel P. Eckstein; 19. Implementation of observer models Matthew A. Kupinski; 20. Value and limitations of observer models Lucretiu M. Popescu; 21. Perception of volumetric data Geoffrey D. Rubin, Trafton Drew and Lauren H. Williams; 22. Performance assessment using standardized data sets: the PERFORMS® scheme in breast screening and other domains Yan Chen and Alastair Gale; 23. Breast screen reader assessment strategy (BREAST): a research infrastructure with a translational objective Patrick Brennan, Lee Warwick and Kriscia Tapia; 24. CAD: an image perception perspective Maryellen Giger and Weijie Chen; 25. Common designs of CAD studies Yulei Jiang; 26. Evaluation of CAD and radiomic tools Berkman Sahiner and Nicholas Petrick; 27. Quantitative imaging – images to numbers Daniel C. Sullivan and Edward F. Jackson; 28. Optimization of 2D and 3D radiographic imaging systems Jeffrey H. Siewerdsen; 29. Display optimization from a physics perspective Alisa Walz-Flannigan and Scott Stekel; 30. Display optimisation from a perception perspective Mark Mcentee and Rachel Toomey; 31. Perception and training William F. Auffermann and Maciej Mazurowski; 32. Ergonomics 2.0: fatigue in medical imaging Sian Taylor-Phillips, Chris Stinton and Elizabeth Krupinski; 33. Perception issues in pathology Liron Pananowitz, Claudia Mello-Thoms and Elizabeth A. Krupinski; 34. Medical image perception from a clinical perspective Francine L. Jacobson; 35. Future of medical image perception Elizabeth A. Krupinski and Ehsan Samei.
£999.99
