Biophysics Books
Transworld Publishers Ltd Life on the Edge
Book SynopsisAre we missing a vital ingredient in its creation? Like Richard Dawkins' The Selfish Gene, which provided a new perspective on evolution, Life on the Edge alters our understanding of life's dynamics as Jim Al-Khalili and Johnjoe Macfadden reveal the hitherto missing ingredient to be quantum mechanics.Trade ReviewHugely ambitious ... the skill of the writing provides the uplift to keep us aloft as we fly through the strange and spectacular terra incognita of genuinely new science. -- Tom Whipple * The Times *Physicist Jim Al-Khalili and molecular biologist Johnjoe McFadden explore this extraordinary realm with cogency and wit. * Nature Magazine *A really original science book about a new field of research ... Groundbreaking. -- Clive Cookson * Financial Times *This thrilling book is an overview of a field that barely exists ... Al-Khalili has a genius for illustrating complex ideas via imaginative sidetracks. * The Sunday Telegraph *'Life on the Edge’ gives the clearest account I’ve ever read of the possible ways in which the very small events of the quantum world can affect the world of middle-sized living creatures like us. With great vividness and clarity it shows how our world is tinged, even saturated, with the weirdness of the quantum. * Philip Pullman *
£10.44
Random House USA Inc Life on the Edge
Book Synopsis
£16.00
Springer Principles of Fluorescence Spectroscopy
Book Synopsisto Fluorescence.- Instrumentation for Fluorescence Spectroscopy.- Fluorophores.- Time-Domain Lifetime Measurements.- Frequency-Domain Lifetime Measurements.- Solvent and Environmental Effects.- Dynamics of Solvent and Spectral Relaxation.- Quenching of Fluorescence.- Mechanisms and Dynamics of Fluorescence Quenching.- Fluorescence Anisotropy.- Time-Dependent Anisotropy Decays.- Advanced Anisotropy Concepts.- Energy Transfer.- Time-Resolved Energy Transfer and Conformational Distributions of Biopolymers.- Energy Transfer to Multiple Acceptors in One,Two, or Three Dimensions.- Protein Fluorescence.- Time-Resolved Protein Fluorescence.- Multiphoton Excitation and Microscopy.- Fluorescence Sensing.- Novel Fluorophores.- DNA Technology.- Fluorescence-Lifetime Imaging Microscopy.- Single-Molecule Detection.- Fluorescence Correlation Spectroscopy.- Radiative Decay Engineering: Metal-Enhanced Fluorescence.- Radiative-Decay Engineering: Surface Plasmon-Coupled Emission.Trade ReviewPraise for Earlier Editions: "Lakowicz’s Principles of Fluorescence Spectroscopy has been the best one-volume introduction to the biophysical principles of fluorescence methods. - Roger Y. Tsien, Ph.D., Department of Pharmacology and Department of Chemistry and Biochemistry, University of California, San Diego, California "Principles of Fluorescence Spectroscopy is encyclopedic and comprehensive." - Britton Chance, Professor Emeritus in Biochemistry and Biophysics,University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania "Recommended without reservation both to the novice and to the expert in fluorescence." - Analytical Biochemistry "In addition to its use as a student text, it should be a particularly valuable reference for those involved in biochemical research." - Chemistry in Britain Advance Praise for Third Edition: "This third edition has significantly expanded the topics, and will remain as a leading reference, as well as a text…the information in the book is valuable for a wide range of disciplines." - Robert M. Clegg, Ph.D., Department of Physics, University of Illinois, Champaign-Urbana, Illinois "Overall this is a most welcome, and timely transformation of the classic, and most comprehensive textbook on fluorescence spectroscopy. It should be the number one item on the shopping list for any student or researcher involved in any aspect of fluorescence, be it as a biologist who does some microscopy, or a chemist synthesizing novel fluorophores." - Alan Ryder, Ph.D., National Centre for Biomedical Engineering Science, National University of Ireland-Galway, Galway, Ireland From the reviews of the third edition: "This book gives an overview of the principles and applications of fluorescence. It is well structured, starting with basic knowledge about the phenomena of fluorescence and ending with the latest applications. … highly readable and informative both by novices and by experienced people. … a helpful work of reference and a wonderful creation for learning and teaching. The updated 3rd edition with its appealing design and its absolutely up-to-date and, nevertheless, complete treatment of fluorescence spectroscopy makes it essential for everyone working in this field." (Christiane Albrecht, Analytical and Bioanalytical Chemistry, Vol. 390, 2008)Table of Contentsto Fluorescence.- Instrumentation for Fluorescence Spectroscopy.- Fluorophores.- Time-Domain Lifetime Measurements.- Frequency-Domain Lifetime Measurements.- Solvent and Environmental Effects.- Dynamics of Solvent and Spectral Relaxation.- Quenching of Fluorescence.- Mechanisms and Dynamics of Fluorescence Quenching.- Fluorescence Anisotropy.- Time-Dependent Anisotropy Decays.- Advanced Anisotropy Concepts.- Energy Transfer.- Time-Resolved Energy Transfer and Conformational Distributions of Biopolymers.- Energy Transfer to Multiple Acceptors in One,Two, or Three Dimensions.- Protein Fluorescence.- Time-Resolved Protein Fluorescence.- Multiphoton Excitation and Microscopy.- Fluorescence Sensing.- Novel Fluorophores.- DNA Technology.- Fluorescence-Lifetime Imaging Microscopy.- Single-Molecule Detection.- Fluorescence Correlation Spectroscopy.- Radiative Decay Engineering: Metal-Enhanced Fluorescence.- Radiative-Decay Engineering: Surface Plasmon-Coupled Emission.
£98.99
Elsevier Science Publishing Co Inc Introduction to Biomedical Engineering
Book SynopsisOffers a comprehensive survey text for biomedical engineering courses. This book helps biomedical engineers to understand the range of topics such as basic mathematical modeling; anatomy and physiology; electrical engineering, signal processing and instrumentation; biomaterials science and tissue engineering; and medical and engineering ethics.Table of Contents1. Biomedical Engineering: A Historical Perspective 2. Moral and Ethical Issues 3. Anatomy and Physiology 4. Biomechanics 5. Biomaterials 6. Tissue Engineering 7. Compartmental Modeling 8. Biochemical Reactions and Enzyme Kinetics 9. Bioinstrumentation 10. Biomedical Sensors 11. Biosignal Processing 12. Bioelectric Phenomena 13. Physiological Modeling 14. Biomedical Transport Processes 15. Radiation Imaging 16. Medical Imaging 17. Biomedical Optics and Lasers
£123.50
Elsevier Science Encyclopedia of Biomedical Engineering
Book Synopsis
£1,387.00
Elsevier Science Publishing Co Inc Purification and Characterization of Secondary
Book SynopsisTable of Contents1. The Structure and Function of Secondary Metabolites that are Secreted by Bacteria2. The Reagents, Supplies and Equipment that are Necessary to Grow Cultures of Bacteria in the Laboratory and to Purify Secreted Metabolites3. Overview of the Methods for Purification of Metabolites that are Secreted by Bacteria4. Absorption Spectrophotometry: Ultraviolet-visible and Infrared5. High-performance Liquid Chromatography6. Mass Spectrometry7. X-ray Crystallography8. Nuclear Magnetic Resonance Spectroscopy9. Exercises in Purifying and Characterizing a Quorum-sensing Signal10. Exercises in Purifying and Characterizing Iron-chelating Molecules11. Exercises in Purifying and Characterizing a Chloroplast-targeting Phytotoxin12. Designing your Own Experiments
£68.96
Elsevier Science Quantitative Human Physiology
£112.50
Oxford University Press Nonequilibrium Statistical Mechanics
Book SynopsisThis book presents the main principles and methods of nonequilibrium statistical mechanics, a topic studied by both chemists and physicists. This book is written for graduate students and scientists who already have knowledge of basic equilibrium statistical mechanics and who are interested in the more complex field of time-dependent nonequilibrium statistical mechanics.Table of Contents1. Brownian Motion and Langevin equations ; 2. Fokker-Planck equations ; 3. Master equations ; 4. Reaction rates ; 5. Kinetic models ; 6. Quantum dynamics ; 7. Linear response theory ; 8. Projection operators ; 9. Nonlinear problems ; 10. The paradoxes of irreversibility ; Appendices
£119.00
Oxford University Press EVOLUTIONARY BIOMECHANICS OSEE P
Book SynopsisEvolutionary biomechanics is the study of evolution through the analysis of biomechanical systems. Its unique advantage is the precision with which physical constraints and performance can be predicted from first principles. Instead of reviewing the entire breadth of the biomechanical literature, a few key examples are explored in depth as vehicles for discussing fundamental concepts, analytical techniques, and evolutionary theory. Each chapter develops a conceptual theme, developing the underlying theory and techniques required for analyses in evolutionary biomechanics. Examples from terrestrial biomechanics, metabolic scaling, and bird flight are used to analyse how physics constrains the design space that natural selection is free to explore, and how adaptive evolution finds solutions to the trade-offs between multiple complex conflicting performance objectives.Evolutionary Biomechanics is suitable for graduate level students and professional researchers in the fields of biomechanicTrade ReviewThis is a scholarly volume that approaches a challenging subject in a straightforward and rigorous manner, which is illuminating without being overpowering...ideal for students who want both depth and a fascinating context. * Ian Carter, The Biologist *This volume provides for all. ... This is a great volume for undergraduates or postdoctoral researchers. * Christian Laurent, Quarterly Review of Biology *Table of Contents1. Themes ; 2. Selection ; 3. Constraint ; 4. Scaling ; 5. Phylogeny ; 6. Form and function in flight ; 7. Adaptation in avian wing design ; 8. Trade-offs: selection, phylogeny and constraint
£39.89
Oxford University Press Physical Chemistry for the Life Sciences
Book SynopsisA balanced presentation of the concepts of physical chemistry, and their applications to biology and biochemistry. Written to straddle the worlds of physical chemistry and the life sciences, it shows how the tools of physical chemistry can elucidate biological questions.Table of ContentsFocus 1: Biochemical Thermodynamics: The First Law Focus 2: Biochemical Thermodynamics: The Second Law Focus 3: Water and Aqueous solutions Focus 4: Chemical equilibrium Focus 5: Ion and Electron Transport Focus 6: The Rates of Reactions Focus 7: Biochemical kinetics Focus 8: Atoms Focus 9: Molecules Focus 10: Macromolecules and self-assembly Focus 11: Biochemical spectroscopy Focus 12: Scattering techniques Focus 13: Gravimetric methods
£137.74
The University of Chicago Press Plant Physics
Book SynopsisPresents a detailed account of the principles of classical physics, evolutionary theory, and plant biology in order to explain the complex interrelationships among plant form, function, environment, and evolutionary history.Trade Review"Brilliant.... This is truly a lovely book." (Plant Science Bulletin) "There is no better way to learn about plants than studying physics and to learn physics than studying plants. This book does just so. In a comprehensive but not overwhelming manner, the authors provide an overview of carefully selected topics that beautifully link descriptions of plant physiological and cellular activity with explanations of the physical forces that shape plant structure and function.... A valuable addition to the book-shelves in all plant biology or physics graduate rooms and for all plant biology or physics teachers." (Quarterly Review of Biology)"
£35.15
Taylor & Francis Ltd RNA the Epicenter of Genetic Information
Book SynopsisThe origin story and emergence of molecular biology is muddled. The early triumphs in bacterial genetics and the complexity of animal and plant genomes complicate an intricate history. This book documents the many advances, as well as the prejudices and founder fallacies. It highlights the premature relegation of RNA to simply an intermediate between gene and protein, the underestimation of the amount of information required to program the development of multicellular organisms, and the dawning realization that RNA is the cornerstone of cell biology, development, brain function and probably evolution itself. Key personalities, their hubris as well as prescient predictions are richly illustrated with quotes, archival material, photographs, diagrams and references to bring the people, ideas and discoveries to life, from the conceptual cradles of molecular biology to the current revolution in the understanding of genetic information.Key Features Documents the confused early history of DNA, RNA and proteins - a transformative history of molecular biology like no other. Integrates the influences of biochemistry and genetics on the landscape of molecular biology. Chronicles the important discoveries, preconceptions and misconceptions that retarded or misdirected progress. Highlights major pioneers and contributors to molecular biology, with a focus on RNA and noncoding DNA. Summarizes the mounting evidence for the central roles of non-protein-coding RNA in cell and developmental biology. Provides a thought-provoking retrospective and forward-looking perspective for advanced students and professional researchers. The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.Trade Review“Thrilling and provocative ... There is a need for such a book... There’s nothing quite like this out there.An epic tale of biology’s central molecule, RNA.DNA does only one thing, store information. RNA has a thrilling plethora of functions, including telling DNA what to do. This book takes the reader on an odyssey through the wonders of RNA and its central role in biology.DNA science dominated the second half of the 20th Century, but it’s clear that the 21st Century belongs to RNA. This long-overdue book reveals the diverse wonders of RNA in a series of thrilling and provocative stories.”Tom Cech, Nobel laureate, University of Colorado Boulder_____________________________________“The book is truly monumental and will be treasured by RNA scientists and others, as well. It beautifully captures the excitement and wonder that I have been lucky to experience working in the RNA field since the early 1960s.”Joan Steitz, Yale University_____________________________________“This book is really disruptive and presents a coherent view of our understanding of biology in terms of the genetic molecules, the nucleic acids, DNA and RNA. It covers an immense territory of molecular biology and its history of discoveries, all presented with a clear-cut intellectual thread.... It is very timely by its breadth and emphasis on the role of RNA in biology. It makes a strong case for RNA and its late acceptance... the fight uphill, like that of Sisyphus, was tough and demanded a lot of perseverance. It is really rather complete.”Eric Westhof, University of Strasbourg_____________________________________“The book is unique. It provides the long-overdue correction of the still widespread static views on evolution, development and genome organization and function. It has the potential to induce radical changes in widely held views and attitudes.”Peter Vogt, Scripps Research Institute, La Jolla_____________________________________"History is the key to our modern understanding of RNA. This magnum opus describes how science, scientific thought and landmark discoveries revealed the central role of RNA in molecular biology and evolution. The authors are not only modern pioneers of RNA science, but also the best histo-RNA-ians of our time.”John Rinn, University of Colorado, Boulder_____________________________________"RNA, the Epicenter of Genetic Information is much more than what its title might suggest. This epic book by Mattick and Amaral superbly reflects the continuing excitement about RNA research. It is not only a description of our current understanding of the role of RNA in cell and developmental biology but is also a useful history of molecular biology. Each of the eighteen chapters is a brilliantly written semi-autonomous essay on a particular segment of the RNA odyssey. I wholeheartedly recommend this book to anybody interested in the biology of RNA, in evolution, and in the organization and function of complex genomes." Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Basel_____________________________________"Those who might think that this book is only for the scientists, think again. It is not. It will appeal in equal measure to the thinking generalist and culturally curious interested in the thrilling history of molecular biology, the wonders of the long-overlooked central molecule RNA and its pivotal role in human development and evolution.An epic, provocative, and highly original book that highlights the way science is so often sidetracked by preconceptions and hubris, and explores the struggle to understand all that junk DNA we were told we had. The junk is not junk! The answers are all there. A story and a journey not to be missed!"Gabriel Farago (USA TODAY Bestselling author of the Jack Rogan Mysteries Series) Table of ContentsPreface, Chapter 1. Overview, Chapter 2. The genetic material?, Chapter 3. Halcyon days, Chapter 4. Worlds apart, Chapter 5. Strange genomes, strange genetics, Chapter 6. The Age of Aquarius, Chapter 7. All that junk, Chapter 8. The expanding repertoire of RNA, Chapter 9. Glimpses of a modern RNA world, Chapter 10. Genome sequences and transposable elements, Chapter 11. The human genome, Chapter 12. Small RNAs with mighty functions, Chapter 13. Large RNAs with many functions, Chapter 14. The epigenome, Chapter 15. The programming of development, Chapter 16. RNA and repeats rule, Chapter 17. Plasticity, Chapter 18. Beyond the jungle of dogmas, References
£39.89
Taylor & Francis Ltd An Introduction to Computational Systems Biology
Book SynopsisThis book delivers a comprehensive and insightful account of applying mathematical modelling approaches to very large biological systems and networksa fundamental aspect of computational systems biology. The book covers key modelling paradigms in detail, while at the same time retaining a simplicity that will appeal to those from less quantitative fields. Key Features: A hands-on approach to modelling Covers a broad spectrum of modelling, from static networks to dynamic models and constraint-based models Thoughtful exercises to test and enable understanding of concepts State-of-the-art chapters on exciting new developments, like community modelling and biological circuit design Emphasis on coding and software tools for systems biology Companion website featuringTrade ReviewThis is a very comprehensive read that provides a solid base in computational biology. The book is structured in 4 parts and 14 chapters which cover all the way from the more basic concepts to advanced material, including the state-of-the-art methodologies in synthetic and systems biology. This is a bedside book for those researchers embarking to do investigation in computational biology and a great office companion for anyone working on systems and synthetic biology. -- Rodrigo Ledesma Amaro, Lecturer, Imperial College London This is a fantastic book. It offers an elegant introduction to both classical and modern concepts in computational biology. To the uninitiated, it is a terrific first read, bringing alive the glory of the past and the promise of the future. To the interested, it handholds and offers a springboard to dive deep. To the practitioner, it serves as a valuable resource bringing together in a panoramic view many diverse streams that adorn the landscape. -- Narendra M. Dixit, Professor, Indian Institute of Science This is a very comprehensive read that provides a solid base in computational biology. The book is structured in 4 parts and 14 chapters which cover all the way from the more basic concepts to advanced material, including the state-of-the-art methodologies in synthetic and systems biology. This is a bedside book for those researchers embarking to do investigation in computational biology and a great office companion for anyone working on systems and synthetic biology. -- Rodrigo Ledesma Amaro, Lecturer, Imperial College London This is a fantastic book. It offers an elegant introduction to both classical and modern concepts in computational biology. To the uninitiated, it is a terrific first read, bringing alive the glory of the past and the promise of the future. To the interested, it handholds and offers a springboard to dive deep. To the practitioner, it serves as a valuable resource bringing together in a panoramic view many diverse streams that adorn the landscape. -- Narendra M. Dixit, Professor, Indian Institute of Science Table of ContentsPreface Introduction to modelling 1.1 WHAT IS MODELLING? 1.1.1 What are models? 1.2 WHYBUILD MODELS? 1.2.1 Why model biological systems? 1.2.2 Why systems biology? 1.3 CHALLENGES IN MODELLING BIOLOGICAL SYSTEMS 1.4 THE PRACTICE OF MODELLING 1.4.1 Scope of the model1.4.2 Making assumptions 1.4.3 Modelling paradigms 1.4.4 Building the model 1.4.5 Model analysis, debugging and (in)validation 1.4.6 Simulating the model 1.5 EXAMPLES OF MODELS 1.5.1 Lotka–Volterra predator–prey model 1.5.2 SIR model: a classic example 1.6 TROUBLESHOOTING 1.6.1 Clarity of scope and objectives 1.6.2 The breakdown of assumptions 1.6.3 Ismy model fit for purpose? 1.6.4 Handling uncertainties EXERCISES REFERENCES FURTHER READING Introduction to graph theory 2.1 BASICS 2.1.1 History of graph theory 2.1.2 Examples of graphs 2.2 WHYGRAPHS? 2.3 TYPES OF GRAPHS 2.3.1 Simple vs. non-simple graphs 2.3.2 Directed vs. undirected graphs 2.3.3 Weighted vs. unweighted graphs 2.3.4 Other graph types 2.3.5 Hypergraphs 2.4 COMPUTATIONAL REPRESENTATIONS OF GRAPHS 2.4.1 Data structures 2.4.2 Adjacency matrix 2.4.3 The laplacian matrix 2.5 GRAPH REPRESENTATIONS OF BIOLOGICAL NETWORKS 2.5.1 Networks of protein interactions and functional associations2.5.2 Signalling networks 2.5.3 Protein structure networks 2.5.4 Gene regulatory networks 2.5.5 Metabolic networks 2.6 COMMONCHALLENGES&TROUBLESHOOTING 2.6.1 Choosing a representation 2.6.2 Loading and creating graphs 2.7 SOFTWARE TOOLS EXERCISES REFERENCES FURTHER READING Structure of networks 3.1 NETWORK PARAMETERS 3.1.1 Fundamental parameters 3.1.2 Measures of centrality 3.1.3 Mixing patterns: assortativity 3.2 CANONICAL NETWORK MODELS 3.2.1 Erdos–Rényi (ER) network model 3.2.2 Small-world networks 3.2.3 Scale-free networks 3.2.4 Other models of network generation 3.3 COMMUNITY DETECTION 3.3.1 Modularity maximisation 3.3.2 Similarity-based clustering 3.3.3 Girvan–Newman algorithm 3.3.4 Other methods 3.3.5 Community detection in biological networks 3.4 NETWORKMOTIFS 3.4.1 Randomising networks 3.5 PERTURBATIONS TO NETWORKS 3.5.1 Quantifying e□fects of perturbation 3.5.2 Network structure and attack strategies 3.6 TROUBLESHOOTING 3.6.1 Is your network really scale-free? 3.7 SOFTWARE TOOLS EXERCISES REFERENCESFURTHER READING Applications of network biology 4.1 THE CENTRALITY–LETHALITY HYPOTHESIS 4.1.1 Predicting essential genes fromnetworks 4.2 NETWORKS AND MODULES IN DISEASE 4.2.1 Disease networks 4.2.2 Identification of disease modules 4.2.3 Edgetic perturbation models 4.3 DIFFERENTIAL NETWORK ANALYSIS 4.4 DISEASE SPREADING ON NETWORKS 4.4.1 Percolation-based models 4.4.2 Agent-based simulations 4.5 MOLECULAR GRAPHS AND THEIR APPLICATIONS 4.5.1 Retrosynthesis 4.6 PROTEIN STRUCTURE, ENERGY & CONFORMATIONAL NETWORKS4.6.1 Protein folding pathways 4.7 LINK PREDICTION EXERCISES REFERENCES FURTHER READING Introduction to dynamic modelling5.1 CONSTRUCTING DYNAMIC MODELS 5.1.1 Modelling a generic biochemical system 5.2 MASS-ACTION KINETIC MODELS 5.3 MODELLING ENZYME KINETICS 5.3.1 The Michaelis–Menten model 5.3.2 Extending the Michaelis–Menten model 5.3.3 Limitations of Michaelis–Menten models 5.3.4 Co-operativity: Hill kinetics 5.3.5 An illustrative example: a three-node oscillator 5.4 GENERALISED RATE EQUATIONS 5.4.1 Biochemical systems theory 5.5 SOLVING ODES 5.6 TROUBLESHOOTING 5.6.1 Handing sti□f equations 5.6.2 Handling uncertainty 5.7 SOFTWARE TOOLS EXERCISES REFERENCES FURTHER READING Parameter estimation 6.1 DATA-DRIVEN MECHANISTIC MODELLING: AN OVERVIEW 6.1.1 Pre-processing the data 6.1.2 Model identification 6.2 SETTING UP AN OPTIMISATION PROBLEM 6.2.1 Linear regression 6.2.2 Least squares 6.2.3 Maximumlikelihood estimation 6.3 ALGORITHMS FOR OPTIMISATION 6.3.1 Desiderata 6.3.2 Gradient-based methods 6.3.3 Direct search methods 6.3.4 Evolutionary algorithms 6.4 POST-REGRESSION DIAGNOSTICS 6.4.1 Model selection 6.4.2 Sensitivity and robustness of biological models 6.5 TROUBLESHOOTING 6.5.1 Regularisation 6.5.2 Sloppiness 6.5.3 Choosing a search algorithm 6.5.4 Model reduction 6.5.5 The curse of dimensionality 6.6 SOFTWARE TOOLS EXERCISES REFERENCES FURTHER READING Discrete dynamic models: Boolean networks 7.1 INTRODUCTION 7.2 BOOLEAN NETWORKS: TRANSFER FUNCTIONS 7.2.1 Characterising Boolean network dynamics 7.2.2 Synchronous vs. asynchronous updates 7.3 OTHER PARADIGMS 7.3.1 Probabilistic Boolean networks 7.3.2 Logical interaction hypergraphs 7.3.3 Generalised logical networks 7.3.4 Petri nets 7.4 APPLICATIONS 7.5 TROUBLESHOOTING 7.6 SOFTWARE TOOLS EXERCISES REFERENCES FURTHER READING Introduction to constraint-based modelling 8.1 WHAT ARE CONSTRAINTS? 8.1.1 Types of constraints 8.1.2 Mathematical representation of constraints 8.1.3 Why are constraints useful? 8.2 THE STOICHIOMETRICMATRIX 8.3 STEADY-STATEMASSBALANCE:FLUXBALANCEANALYSIS (FBA)8.4 THE OBJECTIVE FUNCTION 8.4.1 The biomass objective function 8.5 OPTIMISATION TO COMPUTE FLUX DISTRIBUTION 8.6 AN ILLUSTRATION 8.7 FLUX VARIABILITY ANALYSIS (FVA) 8.8 UNDERSTANDING FBA 8.8.1 Blocked reactions and dead-end metabolites 8.8.2 Gaps in metabolic networks 8.8.3 Multiple solutions8.8.4 Loops 8.8.5 Parsimonious FBA (pFBA) 8.8.6 ATP maintenance fluxes 8.9 TROUBLESHOOTING 8.9.1 Zero growth rate 8.9.2 Objective values vs. flux values 8.10 SOFTWARE TOOLS EXERCISES REFERENCES FURTHER READING Extending constraint-based approaches 9.1 MINIMISATION OF METABOLIC ADJUSTMENT (MOMA) 9.1.1 Fitting experimentally measured fluxes 9.2 REGULATORY ON-OFF MINIMISATION (ROOM) 9.2.1 ROOMvs.MoMA 9.3 BI-LEVEL OPTIMISATIONS 9.3.1 OptKnock9.4 INTEGRATING REGULATORY INFORMATION 9.4.1 Embedding regulatory logic: regulatory FBA (rFBA) 9.4.2 Informing metabolic models with omic data 9.4.3 Tissue-specific models 9.5 COMPARTMENTALISED MODELS 9.6 DYNAMIC FLUX BALANCE ANALYSIS (dFBA) 9.7 13C-MFA 9.8 ELEMENTARY FLUX MODES AND EXTREME PATHWAYS 9.8.1 Computing EFMs and EPs 9.8.2 Applications EXERCISES REFERENCES FURTHER READING Perturbations to metabolic networks10.1 KNOCK-OUTS 10.1.1 Gene deletions vs. reaction deletions 10.2 SYNTHETIC LETHALS 10.2.1 Exhaustive enumeration 10.2.2 Bi-level optimisation 10.2.3 Fast-SL: massively pruning the search space 10.3 OVER-EXPRESSION 10.3.1 Flux Scanning based on Enforced Objective Flux (FSEOF) 10.4 OTHER PERTURBATIONS 10.5 EVALUATING AND RANKING PERTURBATIONS 10.6 APPLICATIONS OF CONSTRAINT-BASED MODELS 10.6.1 Metabolic engineering 10.6.2 Drug target identification 10.7 LIMITATIONS OF CONSTRAINT-BASED APPROACHES 10.7.1 Scope of genome-scale metabolic models 10.7.2 Incorrect predictions 10.8 TROUBLESHOOTING10.8.1 Interpreting gene deletion simulations 10.9 SOFTWARE TOOLS EXERCISES REFERENCES FURTHER READING Modelling cellular interactions 11.1 MICROBIAL COMMUNITIES 11.1.1 Network-based approaches 11.1.2 Population-based and agent-based approaches 11.1.3 Constraint-based approaches 11.2 HOST–PATHOGEN INTERACTIONS (HPIs) 11.2.1 Network models 11.2.2 Dynamic models 11.2.3 Constraint-based models 11.3 SUMMARY11.4 SOFTWARE TOOLS EXERCISES REFERENCES FURTHER READING Designing biological circuits 12.1 WHAT IS SYNTHETIC BIOLOGY? 12.2 FROMLEGO BRICKS TO BIOBRICKS 12.3 CLASSIC CIRCUIT DESIGN EXPERIMENTS 12.3.1 Designing an oscillator: the repressilator 12.3.2 Toggle switch 12.4 DESIGNING MODULES 12.4.1 Exploring the design space 12.4.2 Systems-theoretic approaches 12.4.3 Automating circuit design 12.5 DESIGN PRINCIPLES OF BIOLOGICAL NETWORKS 12.5.1 Redundancy 12.5.2 Modularity 12.5.3 Exaptation 12.5.4 Robustness 12.6 COMPUTING WITH CELLS 12.6.1 Adleman’s classic experiment 12.6.2 Examples of circuits that can compute 12.6.3 DNA data storage 12.7 CHALLENGES 12.8 SOFTWARE TOOLS EXERCISES REFERENCES FURTHER READING Robustness and evolvability of biological systems 13.1 ROBUSTNESS IN BIOLOGICAL SYSTEMS 13.1.1 Key mechanisms 13.1.2 Hierarchies and protocols 13.1.3 Organising principles 13.2 GENOTYPE SPACES AND GENOTYPE NETWORKS 13.2.1 Genotype spaces 13.2.2 Genotype–phenotype mapping 13.3 QUANTIFYING ROBUSTNESS AND EVOLVABILITY 13.4 SOFTWARE TOOLS EXERCISES REFERENCES FURTHER READING Epilogue: The Road Ahead Index 325
£42.74
Springer New York The Physics and Psychophysics of Music An Introduction
Book SynopsisThis book uses acoustics, psychophysics, and neurobiology to explore the physical systems and biological processes that intervene when we hear music. It incorporates the latest findings in brain science and tone generation in musical instruments.Trade ReviewFrom the reviews of the fourth edition:"This book deals with the physical systems and biological processes that interact with music, analyzing ‘what objective, physical properties of sound patterns are associated with what subjective, psychological sensations of music.’ … Roederer is well known for promoting music as a multidisciplinary subject. … While there are plenty of good books on the physics of music … Roederer’s classic is the best. This book will be an asset to any scientific library." (Soubhik Chakraborty, ACM Computing Reviews, November, 2009)“This book … not only suitable for lay-readers, but can also act as a springboard for more technically minded readers wishing to pursue a thorough foray into the field. … open questions which makes the reader want to come back for more. Credit can only be given to the author for creating such an engaging read. … this fourth edition of the book incorporates a number of recent results supporting hypotheses posited in earlier versions … .” (Matthew R. Foreman, Contemporary Physics, Vol. 52 (3), May-June, 2011)“The different aspects of the close relationship between science and music are discussed in this book. … will be of interest to the non-science student, or simply to the music addict teenager … . The book will definitively be pleasant … reading for a scientist with a strong interest or love in music.” (Gary J. Long and Fernande Grandjean, Belgian Physical Society Magazine, Issue 3, 2010)Table of ContentsPreface.- The Science of Music and the Music of Science: A Multidisciplinary Overview.- Sound Vibrations, Pure Tones, and the Perception of Pitch.- Sound Waves , Acoustic Energy, and the Perception of Loudness.- Generation of Musical Sounds, Complex Tones, and the Perception of Timbre.- Superposition and Succession of Complex Tones, and the Integral Perception of Music.- Appendix 1: Some Quantitative Aspects of the Bowing Mechanism.- Appendix II: Some Quantitative Aspects of Central Pitch Processor Models.- Appendix III: Some Renarks on Teaching of Physics and Psychophysics of Music.- References.- Index
£49.49
Springer-Verlag New York Inc. Advances in Electromagnetic Fields in Living
Book SynopsisThis comprehensive and topical volume presents a number of significant advances on many fronts in this area of research, particularly emphasizing current and future biomedical applications of electromagnetic fields. Table of ContentsFetal Magnetocardiography.- Microwave Thermoelastic Tomography and Imaging.- Diffuse Optical Imaging.- Optical Biotelemetry.- Extremely Low Frequency Magnetic Fields (ELFMF) and Pain Therapy.- The Charge-to-Mass ICR Signature in Weak ELF Bioelectromagnetic Effects.
£112.49
Springer-Verlag New York Inc. Handbook of Sample Preparation for Scanning Electron Microscopy and Xray Microanalysis
Book SynopsisScanning electr on microscopy (SEM) and x-ray microanalysis can produce magnified images and in situ chemical information from virtually any type of specimen. The two instruments generally operate in a high vacuum and a very dry environment in order to produce the high energy beam of electrons needed for imaging and analysis. With a few notable exceptions, most specimens destined for study in the SEM are poor conductors and composed of beam sensitive light elements containing variable amounts of water. In the SEM, the imaging system depends on the specimen being sufficiently electrically conductive to ensure that the bulk of the incoming electrons go to ground. The formation of the image depends on collecting the different signals that are scattered as a consequence of the high energy beam interacting with the sample. Backscattered electrons and secondary electrons are generated Trade ReviewThis handbook should find its way to the reference bookshelf of all imaging laboratories. It should also become required reading for anyone being trained for SEM work, or anyone who might need to have their samples examined by using such techniques. In that way, it will be less likely that deficient results will be published and that the full potential of the SEM be realized. -- Iolo ap Gwynn, Microscopy and Microanalysis (2010)Table of ContentsSample Collection and Selection.- Sample Preparation Tools.- Sample Support.- Sample Embedding ?and Mounting.- Sample Exposure.- Sample Dehydration.- Sample Stabilization for Imaging in the SEM.- Sample Stabilization to Preserve Chemical Identity.- Sample Cleaning.- Sample Surface Charge Elimination.- Sample Artifacts and Damage.- Additional Sources of Information.
£113.99
Springer New York The Mathematics and Mechanics of Biological
Book SynopsisThis monograph presents a general mathematical theory for biological growth. The author herein presents the first major technical monograph on the problem of growth since D’Arcy Wentworth Thompson’s 1917 book On Growth and Form.The emphasis of the book is on the proper mathematical formulation of growth kinematics and mechanics.Trade Review“Goriely’s book is self-contained and provides sufficient review of the background material necessary to understand the mathematics employed in the study of phenomena he describes. … Overall, the text is well written, richly illustrated, and enjoyable to read, although the monograph is lengthy. I applaud Prof. Goriely on his impressive text.” (Bhargav Karamched, SIAM Review, Vol. 61 (1), March, 2019)“The book grasps the conceptual and technical aspects underpinning the role of mechanics in the growth of biological tissues. It is the first major modern monograph on the subject, which synthesizes the research activity in this vivid field of the mathematics and mechanics of growth since now more than two decades. … The monograph is overall well-structured and rich in illustrations and will be accessible and appealing to readers with different interest and background, including life scientists … .” (Jean-François Ganghoffer, Journal of Geometry and Symmetry in Physics JGSP, Vol. 49, 2018)“The book is very informative, it is written in an easy readable and intriguing way. It has a large reference list of 1369 bibliographic descriptions and a carefully prepared index. The book should be helpful for researchers who work in the multidisciplinary fields of theoretical biology, biomechanics, biomedical engineering, biophysics and applied mathematics.” (Svetoslav Markov, zbMATH 1398.92003, 2018)Table of ContentsBasic aspects of growth.- Mechanics and growth.- Discrete computational models.- Growing on a line.- Elastic rods.- Morphoelastic rods.- Accretive growth.- Membranes and shells.- Growing membranes.- Morphoelastic plates.- Nonlinear elasticity.- The kinematics of growth.- Balance laws.- Evolution laws and stability.- Growing spheres.- Growing cylinders.- Ten challenges.- References.- Index.
£93.60
Springer-Verlag New York Inc. Mathematical Biology
Book SynopsisProviding an in-depth look at the practical use of math modeling, it features exercises throughout that are drawn from a variety of bioscientific disciplines - population biology, developmental biology, physiology, epidemiology, and evolution, among others.Trade ReviewReviews of the original edition: "Murray has produced a magnificent compilation of mathematical models and their applications in biology." Nature "Murray's Mathematical Biology belongs on the shelf of any person with a serious interest in mathematical biology." Bulletin of Mathematical Biology SIAM, 2004: "Murray's Mathematical Biology is a classic that belongs on the shelf of any serious student or researcher in the field. Together the two volumes contain well over 1000 references, a rich source of material, together with an excellent index to help readers quickly find key words. ... I recommend the new and expanded third edition to any serious young student interested in mathematical biology who already has a solid basis in applied mathematics." From the reviews of the third edition: "Mathematical Biology would be eminently suitable as a text for a final year undergraduate or postgraduate course in mathematical biology … . It is also a good source of examples for courses in mathematical methods … . Mathematical Biology provides a good way in to the field and a useful reference for those of us already there. It may attract more mathematicians to work in biology by showing them that there is real work to be done." (Peter Saunders, The Mathematical Gazette, Vol. 90 (519), 2006)Table of ContentsContinuous Population Models for Single Species * Discrete Population Models for a Single Species * Models for Interacting Populations * Temperature-Dependent Sex Determination (TSD): Crocodilian Survivorship * Modelling the Dynamics of Marital Interaction: Divorce Prediction and Marriage Repair * Reaction Kinetics * Biological Oscillators and Switches * BZ Oscillating Reactions * Perturbed and Coupled Oscillators and Black Holes * Dynamics of Infectious Diseases: Epidemic Models and AIDS * Reaction Diffusion, Chemotaxis, and Non-local Mechanisms * Oscillator Generated Wave Phenomena and Central Pattern Generators * Biological Waves: Single Species Models * Use and Abuse of Fractals
£80.99
Springer-Verlag New York Inc. Mathematical Biology II
Book SynopsisThis richly illustrated third edition provides a thorough training in practical mathematical biology and shows how exciting mathematical challenges can arise from a genuinely interdisciplinary involvement with the biosciences.Trade ReviewFrom the reviews: "The 2nd volume of the authors elucidating work highlights a surprisingly broad spectrum of applications in the field of mathematical biology. The sense given to the mathematical texture of thoughts broadens the reader’s insight … . The growing number of specialists in sub-disciplines of mathematical biology will be enjoying the truly concise approach … . It can so be said that the foremost results … might be essential for new interpretations of data … . It is a recommended text for mathematicians … ." (Daniel Gertsch, Bioworld, Issue 2, 2004) From the reviews of the third edition: "This is the second volume of the third edition of Murray’s ‘Mathematical Biology’. … covers a wide variety of problems in pattern formation, each discussed in its biological context. … This volume alone is a large book, with more than 800 pages and a similar number of references. … it is a valuable collection of results from different areas of mathematical biology." (Carlo Laing, New Zealand Mathematical Society Newsletter, Issue 90, April, 2004) "This book, a classical text in mathematical biology, cleverly combines mathematical tools with subject area sciences. The multi-layer way of material presentation makes the book useful for different types of reader including graduate-level students, bioscientists … . it is an enjoyable reading and I recommend it to anyone with serious interest in mathematical modelling." (V.V. Fedorov, Short Book Reviews, Vol. 23 (3), 2003) "This second volume of the third edition of Murray’s Mathematical biology focuses on partial differential equations (spatial models) and their application to the biomedical sciences. … Each chapter deals with its particular topic in great detail, usually focusing on one biological example and the associated mathematical model and results. This volume is not an introductory text … making it extremely useful in graduate courses and for reference." (Trachette L. Jackson, Mathematical Reviews, 2004b) "In this second volume … the development towards specific biological configurations and towards a mechanism for understanding morphogenesis represents an important portion of the work. … chapters deal with attractive topics … . There is an extensive index at the end. … very interesting and strongly recommended." (A. Akutowicz, Zentralblatt MATH, Vol. 1006, 2003) "In this volume it becomes clear that compiling the third edition was a ‘labor of love’. The book has a significantly different feel from the original first edition. … my reaction to the third edition was positive. … The historical and biological overviews have much interesting information. … Certainly, the spicy writing will keep students alert … . In summary, I recommend the new and expanded third edition to any serious young student interested in mathematical biology … ." (Leah Edelstein-Keshet, SIAM Review, Vol. 46 (1), 2004) "Mathematical Biology would be eminently suitable as a text for a final year undergraduate or postgraduate course in mathematical biology … . It is also a good source of examples for courses in mathematical methods … . Mathematical Biology provides a good way into the field and a useful reference for those of us already there. It may attract more mathematicians to work in biology by showing them that there is real work to be done." (Peter Saunders, The Mathematical Gazette, Vol. 90 (518), 2006)Table of ContentsMulti-Species Waves and Practical Applications * Spatial Pattern Formation with Reaction Diffusion Systems * Animal Coat Patterns and Other Practical Applications of Reaction Diffusion Mechanisms * Pattern Formation on Growing Domains: Alligators and Snakes * Bacterial Patterns and Chemotaxis * Mechanical Theory for Generating Pattern and Form in Development * Evolution, Morphogenetic Laws, Developmental Constraints and Teratologies * A Mechanical Theory of Vascular Network Formation * Epidermal Wound Healing * Dermal Wound Healing * Growth and Control of Brain Tumours * Neural Models of Pattern Formation * Geographic Spread and Control of Epidemics * Wolf Territoriality, Wolf-Deer Interaction and Survival
£107.99
Physics in Biology and Medicine
Book Synopsis
£69.26
£131.10
Elsevier Science Comprehensive Biomedical Physics
Book Synopsis
£2,479.50
John Wiley & Sons Inc StructureFunction Analysis of G ProteinCoupled
Book SynopsisG protein-coupled receptors (GPCRs) are the largest single class of receptors in biology, often playing key roles in a remarkably large number of physiological and pathophysiological conditions. GPCRs or GPCR-dependent signalling pathways are the targets of a very large number of therapeutically useful drugs. Detailed knowledge about the molecular structure of GPCRs should therefore pave the way for the design of novel drugs with increased efficacy and specificity. This volume provides a concise, up-to-date presentation of methods (including molecular genetic, biochemical, and biophysical) which have been used successfully in studying the structure and function of GPCRs. With contributions from international leaders in the field, the editor provides overviews of various techniques, followed by in-depth descriptions of basic procedures and discussions of critical experimental parameters. Divided into specific, accessible sections, Structure-Function Analysis of G ProteTable of ContentsPartial table of contents: Overview of Mutagenesis Techniques (T. Fong). The Substituted-Cysteine Accessibility Method (J. Javitch). Metal-Ions as Atomic Scale Probes of G Protein-Coupled Receptor Structure (J. Schetz & D. Sibley). Genetic Approaches for Studying the Structure and Function of G Protein-Coupled Receptors in Yeast (C. Sommers & M. Dumont). Electron-Crystallographic Analysis of Two-Dimensional Rhodopsin Crystals (G. Schertler). Site-Directed Spin-Labeling (SDSL) Studies of the G Protein-Coupled Receptor Rhodopsin (D. Farrens). Lead Discovery and Development for G Protein-Coupled Receptors (D. Underwood & M. Cascieri). Index.
£276.26
John Wiley & Sons Inc An Introductionto Radiobiology
Book SynopsisThis new edition of A.H.W. Nias' successful book provides an updated and revised introduction to quantitative radiobiology, particularly, to those aspects of the subject which have a practical application. Radiation is used to cure cancer but can also cause it. Radiation is also used in medical diagnosis and in nuclear power stations.Table of ContentsHistory and Definitions. Cells and Tissues. Proliferation Kinetics. Ionizing Radiations. Subcellular Radiobiology. Radiation Cell Damage. Reparable Damage. Intrinsic Radiosensitivity. Densely Ionizing Radiation. The Oxygen Effect. Radiosensitizers and Radioprotectors. Normal and Malignant Cells. Radiation Pathology. Whole-Body Radiation. Proliferation Kinetics after Radiation. Fractionated Radiotherapy. Protracted Radiation. Diagnostic Radiology. Environmental Radiation. Radiation Protection. Further Reading. Glossary. Index.
£111.56
Cambridge University Press Origin Evolution Planetary Nebulae 33 Cambridge Astrophysics Series Number 33
Book SynopsisThis authoritative volume provides a comprehensive review of the origin and evolution of planetary nebulae. It covers all the stages of their evolution, carefully synthesizes observations from across the spectrum, and clearly explains all the key physical processes at work. Particular emphasis is placed on observations from space, using the Hubble Space Telescope, the Infrared Space Observatory, and the ROSAT satellite. This book presents a thoroughly modern understanding of planetary nebulae, integrating developments in stellar physics with the dynamics of nebular evolution. It also describes exciting possibilities such as the use of planetary nebulae in determining the cosmic distance scale, the distribution of dark matter and the chemical evolution of galaxies. This book provides graduate students with an accessible introduction to planetary nebulae, and researchers with an authoritative reference. It can also be used as an advanced text on the physics of the interstellar medium.Trade Review'… an accessible account of the origin and evolution of these enigmatic shells of gas. the generous, colourful images are the best feature of the book, but the text reveals the speedy evolution of ideas - matching the increase in data - in this complex field, as a microcosm of the way in which modern astronomy is developing.' Astronomy & Geophysics'The book addresses three aspects of planetary nebula (PN) research: radiation mechanisms and PN evolution and the associated spin-offs in laboratory spectroscopy. Kwok's book is now the standard reference.' Irish Astronomical Journal'This book presents a thoroughly modern understanding of planetary nebulae, integrating new developments in stellar physics with the dynamics of nebular evolution.' Europe & Astronomy'… a valuable contribution … It offers the most complete and accessible entry to this subject for the newcomer with a strong general background in physics and astronomy at the advanced undergraduate level or above.' Physics Today'… it was a sheer pleasure to read this new book by Sun Kwok. The book is slim and stylish, characteristic of the Cambridge Astrophysics Series.' Dr X.-W. Lou, Contemporary PhysicsTranslation: 'In sum, The Origin and Evolution of Planetary Nebulae is a technical book undeniably rich demonstrations, quantitative data and mathematical formulas, which is primarily intended for researchers and graduate students in astronomy and astrophysics.' Yves Laberge, Physics in CanadaTable of ContentsPreface; 1. History and overview; 2. Ionization structure of planetary nebulae; 3. Nebular line radiation; 4. Nebular continuum radiation; 5. The neutral gas component; 6. The dust component; 7. Observations of the central star of planetary nebulae; 8. Morphologies of planetary nebulae; 9. Problems and questions; 10. Asymptotic giant branch stars - progenitors of planetary nebulae; 11. Evolution of the central stars; 12. Formation of planetary nebulae; 13. Dynamical evolution of planetary nebulae; 14. Proto-planetary nebulae - the transition objects; 15. Evolution to the white dwarf stage; 16. Distances to planetary nebulae; 17. Comparison between evolutionary models and observations; 18. PN in the galactic context; 19. Chemical abundances; 20. Planetary nebulae in other galaxies; 21. Concluding remarks; References; Appendix: list of symbols and abbreviations; Subject index.
£53.99
Cambridge University Press Mechanics of the Cell
Book SynopsisExploring the mechanical features of biological cells, including their architecture and stability, this textbook is a pedagogical introduction to the interdisciplinary fields of cell mechanics and soft matter physics from both experimental and theoretical perspectives. This second edition has been greatly updated and expanded, with new chapters on complex filaments, the cell division cycle, the mechanisms of control and organization in the cell, and fluctuation phenomena. The textbook is now in full color which enhances the diagrams and allows the inclusion of new microscopy images. With around 280 end-of-chapter exercises exploring further applications, this textbook is ideal for advanced undergraduate and graduate students in physics and biomedical engineering. A website hosted by the author contains extra support material, diagrams and lecture notes, and is available at www.cambridge.org/Boal.Trade ReviewReviews of the first edition: 'In Mechanics of the Cell David Boal explains the mechanical properties of the biopolymers found within cells … for graduate students in the general field and for biotechnologists required to consider added dimensions to their work it represents a comprehensive text that ought to make it a standard reference for many years.' Ian Jones, Chemistry in Britain'If we were really honest with ourselves, most of us would have to admit that we often take the humble biological cell for granted … David Boal describes the architecture of the biological cell's internal and external structure in extensive detail … This book is highly detailed; by virtue of the incredibly complex mechanics underlying the specialised properties of biological cells, it needs to be!' Kevin Coward, Biologist'This book is by a physicist attempting to get across the underlying physical principles behind biological structures … a very useful text, which fills a hole in the literature, and will serve as a useful reference for a number of years to come.' John Seddon, Chemistry IndustryTable of ContentsPreface; List of symbols; 1. Introduction to the cell; 2. Soft materials and fluids; Part I. Rods and Ropes: 3. Polymers; 4. Complex filaments; 5. Two-dimensional networks; 6. Three-dimensional networks; Part II. Membranes: 7. Biomembranes; 8. Membrane undulations; 9. Intermembrane and electrostatic forces; Part III. The Whole Cell: 10. Structure of the simplest cells; 11. Dynamic filaments; 12. Growth and division; 13. Signals and switches; Appendixes; Glossary; References; Index.
£75.99
Princeton University Press Air and Water The Biology and Physics of Lifes
Book SynopsisAddressing general readers and biologists, this title shows how the physics of fluids (in this case, air and water) influences the often fantastic ways in which life forms adapt themselves to their terrestrial or aquatic 'media'.Trade ReviewWinner of the 1993 Award for Best New Book, Professional and Scholarly Division of the American Association of Univeristy Publishers "Seldom does one come across a science book that weighs 1.5 kg, is packed with information, and yet makes fascinating reading from cover to cover... [Denny] relates the ability of living organisms to exist, move, and function to the bulk physical properties of the two substrates peculiar to Earth: air and water... The biological examples are beautifully chosen and the author displays a fine sense of humor."--Felix Franks, Nature "This is an interesting and fascinating book for the biologist and environmental scientist, who are often faced with the problem of resolving the interactions between organisms and their environment but rarely have an adequate or sufficiently detailed knowledge of the underlying physical principles to achieve a satisfactory resolution. In considering the interdependence between the physics of air and water, and the functional biology of the organisms which have evolved and adapted to terrestrial or aquatic environments, Denny has focused our attention on how the differences in many attributes of life, such as size and shape, can be explained by the physics of fluids."--Dennis A. Baker, The Times Higher Education Supplement
£56.00
Princeton University Press Applications of Modern Physics in Medicine
Book SynopsisMany remarkable medical technologies, diagnostic tools, and treatment methods have emerged as a result of modern physics discoveries in the last century--including X-rays, radiation treatment, laser surgery, high-resolution ultrasound scans, computerized tomography (CT) scans, and magnetic resonance imaging. This undergraduate-level textbook descriTrade Review"Applications of Modern Physics in Medicine fills an important need: it explains the physics principals behind commonly used medical diagnostic and therapeutic procedures to scientists, engineers, and technicians working in the field. The necessary basic physics is discussed clearly and simply in early chapters and then used effectively and convincingly in later chapters covering medical applications. This lovely book should lead to the creation of new physics courses all over the world."—Gerald Miller, University of Washington"With a refreshing and accessible style, this textbook grounds medical physics in familiar physical principles, making it useful for undergraduate physics teaching. This book will have a place in a wide range of biomedical science courses and medical physics undergraduate modules, and as supplementary reading for medical doctors, radiographers, and other health professionals." —Mike Partridge, Gray Institute for Radiation Oncology and Biology, University of Oxford"Bridging the gap between the fundamental concepts of modern physics and medical technology in modern medicine, this book encompasses large numbers of topics from X-rays and gamma rays to lasers, MRI, ultrasound, and therapeutic applications of modern physics technologies. It will serve as a good introductory text to students in biomedical engineering, medical physics, health physics, and biophysics."—Terry T. Yoshizumi, Duke University School of MedicineTable of ContentsPreface and Guide to Using This Book xi Technical Abbreviations xv Timeline of Seminal Discoveries in Modern Physics xvii Timeline of Discoveries and Inventions in Modern Medical Physics xix Chapter 1 Introduction 1.1 Overview 1 1.2 The Meaning of the Term Modern Physics 5 1.3 Mortality 6 1.4 How to Use This Book 7 Exercises 8 Chapter 2 When You Visit Your Doctor: The Physics of the "Vital Signs" 2.1 Introduction 10 2.2 Stethoscope 11 2.3 Sphygmomanometer and Blood Pressure 12 2.4 Electrocardiogram 15 2.5 Physics and Physiology of Diet, Exercise, and Weight 17 Exercises 21 Chapter 3 Particles, Waves, and the Laws that Govern Them 3.1 What Is Modern Physics? 22 3.2 Light: Particle or Wave? 25 3.3 Atoms 30 3.4 Lasers 41 3.5 Relativity 45 3.6 Nuclei 53 3.7 X-Rays and Radioactivity 63 Exercises 80 Chapter 4 Photon and Charged-Particle Interactions with a Medium 4.1 Overview 84 4.2 Mean Free Path and Cross Sections 85 4.3 Photon Interactions 87 4.4 Electron and Positron Interactions 98 Exercises 104 Chapter 5 Interactions of Radiation with Living Tissue 5.1 Introduction 107 5.2 Cell Death Due to DNA Radiation Damage 108 5.3 Dependence of Cell Survival on the Dose 112 5.4 Low Doses of Radiation 116 5.5 Radiation Dose versus Altitude 119 Exercises 121 Chapter 6 Diagnostic Applications I: Photons and Radionuclides 6.1 Overview 122 6.2 Photons 122 6.3 X-Rays and Gamma Rays 133 6.4 Radionuclides 156 6.5 Novel Ideas for Nuclear Imaging 166 Exercises 168 Chapter 7 Diagnostic Applications II: MRI and Ultrasound 7.1 Overview 171 7.2 Magnetic Resonance Imaging (MRI) 172 7.3 Ultrasound 199 7.4 Multimodal Imaging 220 Exercises 224 Chapter 8 Applications in Treatment 8.1 Overview 226 8.2 Treatment with Radiation 226 8.3 Treatment with Particles 233 8.4 Treatment with Ultrasound 239 8.5 Treatment with Microwaves 244 8.6 Treatment with Lasers 244 Exercises 246 Appendix A Constants, Powers of 10, and Conversions Mentioned in the Text Fundamental Constants 247 Powers of 10 and Their Prefixes 247 Conversion Factors and Equations 248 Appendix B Mortality Modeling 251 Appendix C Evaluation of the Sound Field from One Transducer Far-field (Fraunhofer) Region 255 Near-field (Fresnel) Region 257 Notes 261 Index 267
£63.75
Princeton University Press Glimpses of Creatures in Their Physical Worlds
Book SynopsisOffers a look into how the characteristics of the physical world drive the designs of animals and plants. This title contains information related to functional biology. Drawing examples from creatures of land, air, and water, it demonstrates the many uses of biological diversity and how physical forces impact biological organisms.Trade Review"If what you desire in a readable science book is food for thought, Glimpses of Creatures in their Physical Worlds provides a feast. Biologists, engineers, and physicists--indeed, anyone with curiosity about the natural world--will revel in this smorgasbord of biomechanical ideas."--Mark Denny, American Scientist "Such a book could be written only by someone with a rich knowledge of biomechanics, and Vogel, an emeritus professor of biology at Duke University, fits the bill. Considered one of the founders of the biomechanics community in the US, his distinguished research career has focused on organism-fluid interactions and such diverse topics as the behavior of leaves in the wind, passive ventilation of prairie-dog burrows, and airflow through the branching antennae of some moths. His breadth of knowledge is clearly reflected in the examples presented and the creative thought embodied in Glimpses of Creatures in Their Physical Worlds. Vogel uses the same approachable, entertaining writing style... [T]his book is sure to serve as an inspiring entry into the field of biomechanics."--Stacey Combes, Physics Today "It is a fine book and emphasizes important relationships too often neglected."--Choice "As ever, Vogel is inspiring and his insights are remarkable."--Henry Bennet-Clark, BioScienceTable of ContentsPreface vii Chapter One: Two Ways to Move Material 1 Chapter Two: The Bioballistics of Small Projectiles 18 Chapter Three: Getting Up to Speed 39 Chapter Four: Moving Heat Around 58 Chapter Five: Maintaining Temperature 80 Chapter Six: Gravity and Life in the Air 95 Chapter Seven: Gravity and Life on the Ground 116 Chapter Eight: Gravity and Life in Water 141 Chapter Nine: Making and Maintaining Liquid Water 164 Chapter Ten: Pumping Fluids through Conduits 184 Chapter Eleven: To Twist or Bend When Stressed 209 Chapter Twelve: Keeping Up Upward and Down Downward 232 List of Symbols 259 References and Index of Citations 263 Index 289
£42.50
Princeton University Press Biophysics
Book SynopsisOffers important lessons about the opportunities for quantitative, physics-style experiments on diverse biological phenomena. This title emphasizes the unifying power of abstract physical principles to motivate advanced experiments on biological systems. It covers a range of biological phenomena from the physicist's perspective.Trade ReviewWilliam Bialek, Winner of the 2013 Swartz Prize for Theoretical and Computational Neuroscience, Society for Neuroscience "[T]he book goes beyond being a structured material for readers to learn about biophysics; it takes readers on an incredible journey in discovering fascinating ways in which biological phenomena can be viewed and studied. The technical adroitness and more importantly, the unique way of thinking about biological problems, in the reviewer's opinion, makes the book a must-read for any aspiring biophysicists."--Angie Ma, Contemporary Physics "[P]hysicists who are seeking an exciting intellectual path through the complexity of biology will deeply appreciate Bialek's clear vision of the big ideas and his expert guidance through their many applications."--Stephen J. Hagen, Physics Today "The book is well crafted, linking the historic work of the 'giants', e.g. Helmholtz with his seminal view of vision and hearing, with latest and trendy research, exemplified by the use of information theory in biology."--Robert Endres, Biological Physics Group NewsletterTable of ContentsAcknowledgments ix PART I EXPLORING THE PHENOMENA 1. Introduction 3 *1.1 About Our Subject 3 *1.2 About This Book 11 2. Photon Counting in Vision 17 *2.1 A First Look 17 *2.2 Dynamics of Single Molecules 51 *2.3 Biochemical Amplification 68 *2.4 The First Synapse and Beyond 97 *2.5 Coda 115 3. Lessons, Problems, Principles 117 PART II CANDIDATE PRINCIPLES 4. Noise Is Not Negligible 127 *4.1 Fluctuations and Chemical Reactions 127 *4.2 Motility and Chemotaxis in Bacteria 149 *4.3 Molecule Counting, More Generally 172 *4.4 More about Noise in Perception 192 *4.5 Proofreading and Active Noise Reduction 218 *4.6 Perspectives 245 5. No Fine Tuning 247 *5.1 Sequence Ensembles 248 *5.2 Ion Channels and Neuronal Dynamics 279 *5.3 The States of Cells 299 *5.4 Long Time Scales in Neural Networks 329 *5.5 Perspectives 349 6. Efficient Representation 353 *6.1 Entropy and Information 354 *6.2 Noise and Information Flow 369 *6.3 Does Biology Care about Bits? 395 *6.4 Optimizing Information Flow 421 *6.5 Gathering Information and Making Models 449 *6.6 Perspectives 467 7. Outlook 469 Appendix Some Further Topics 473 * A.1 Poisson Processes 473 * A.2 Correlations, Power Spectra, and All That 484 * A.3 Diffraction and Biomolecular Structure 495 * A.4 Electronic Transitions in Large Molecules 503 * A.5 The Kramers Problem 512 * A.6 Berg and Purcell, Revisited 521 * A.7 Maximum Entropy 533 * A.8 Measuring Information Transmission 545 Annotated Bibliography 557 Index 625
£80.75
Princeton University Press From Photon to Neuron
Book SynopsisTrade Review"From Photon to Neuron: Light, Imaging, Vision completes a trilogy begun by Biological Physics and Physical Models of Living Systems. Those works establish Nelson as the preeminent author of textbooks at the intersection of physics and biology. . . . Nelson uses words, pictures, formulas, and code to teach students how to construct models and interpret data. His books provide a master class in how to integrate those four different approaches into a complete learning experience."---Bradley Roth, Physics Today"A thorough and sweeping tour from the fundamental physics of light to the neurobiology of the retina, with many asides into modern advances in imaging. Lavishly illustrated and carefully explained. . . . The book itself is a gem."---Sönke Johnsen, American Journal of Physics"As elegant as it is deep. A masterful tour of the science of light and vision, it goes beyond artificial boundaries between disciplines and presents all aspects of light as it appears in physics, chemistry, biology and the neural sciences. . . . In the same way that the author instructs non-physics students in some basic physics concepts and tools, he also provides physicists with accessible and very clear presentations of many biological phenomena involving light. . . . One of the most insightful, cross-disciplinary texts I have read in many years. It is mesmerising and will become a landmark in rigorous, but highly accessible interdisciplinary literature."---Luis Alvarez-Gaumé, CERN Courier
£46.75
Princeton University Press The SelfAssembling Brain
Book SynopsisTrade Review"Hiesinger elegantly moves through a variety of topics, ranging from biological development to AI and ending with a discussion of the advances that deep neural networks have brought to the field of brain-machine interfaces."---Kamila Maria Jóźwik, Science"Hiesinger suggests that instead of looking at the brain from an endpoint perspective, we should study how information encoded in the genome is transformed to become the brain as we grow. . . . The Self-Assembling Brain is organized as a series of seminar presentations interspersed with discussions between a robotics engineer, a neuroscientist, a geneticist, and an AI researcher. The thought-provoking conversations help to understand the views and the holes of each field on topics related to the mind, the brain, intelligence, and AI."---Ben Dickson, TechTalks"For anyone interested in the brain, or AI, or any of the myriad of branches and subbranches of each, I would highly recommend this!"---Jonathan Shock, Mathemafrica
£29.75
Princeton University Press So Simple a Beginning
Book SynopsisTrade Review"Hands down the most beautiful book I’ve ever read. . . . The intersection of biology and physics might be the most underappreciated cross-over in the sciences."---Nicole Barbaro, Bookmarked"The author's style is mostly captivating, and the illustrations provide unique support . . . Parthasarathy's commitment regarding the importance of education about scientific discovery and its place in today's world is evident throughout."---F. W. Yow, Choice
£25.50
Princeton University Press The SelfAssembling Brain
Book SynopsisTrade Review"Hiesinger elegantly moves through a variety of topics, ranging from biological development to AI and ending with a discussion of the advances that deep neural networks have brought to the field of brain-machine interfaces."---Kamila Maria Jóźwik, Science"Hiesinger suggests that instead of looking at the brain from an endpoint perspective, we should study how information encoded in the genome is transformed to become the brain as we grow. . . . The Self-Assembling Brain is organized as a series of seminar presentations interspersed with discussions between a robotics engineer, a neuroscientist, a geneticist, and an AI researcher. The thought-provoking conversations help to understand the views and the holes of each field on topics related to the mind, the brain, intelligence, and AI."---Ben Dickson, TechTalks"For anyone interested in the brain, or AI, or any of the myriad of branches and subbranches of each, I would highly recommend this!"---Jonathan Shock, Mathemafrica
£19.00
Princeton University Press So Simple a Beginning
Book Synopsis
£18.04
CRC Press Huang H Introduction to Cell Mechanics and
Book SynopsisIntroduction to Cell Mechanics and Mechanobiology is designed for a one-semester course in the mechanics of the cell offered to advanced undergraduate and graduate students in biomedical engineering, bioengineering, and mechanical engineering. It teaches a quantitative understanding of the way cells detect, modify, and respond to the physical properties within the cell environment. Coverage includes the mechanics of single molecules, polymers, polymer networks, two-dimensional membranes, whole-cell mechanics, and mechanobiology, as well as primer chapters on solid, fluid, and statistical mechanics, and cell biology.Introduction to Cell Mechanics and Mechanobiology is the first cell mechanics textbook to be geared specifically toward students with diverse backgrounds in engineering and biology.Trade Review"The new text from Jacobs, Huang, and Kwon is fully worthy of the honor of being the first text reviewed in Cellular and Molecular Bioengineering. After reading through the clear, simple, but rigorous text, I can say that their work does far more than just tie together some important notes in a single binding....this text is potentially transformative for the field, much in the way that the famous texts by Beer and Johnston, in the 1960s were transformative for the undergraduate study of mechanics of materials and machines." - Cellular and Molecular Bioengineering "This excellent book by a group of internationally recognized authors meets a real existing need in contemporary bioengineering education, and it does it effectively and successfully....The book was exactly what I wanted; it was entirely devoted to cell-scale problems, with numerous examples, each providing the relevant engineering or mathematical formulation, at a level suitable for good undergrad BME students....All chapters are comprehensible, logically-built and concise, and each is supported by high-quality graphics which add very much to the clarity of the contents...this book is a 'must-have'." - Computer Methods in Biomechanics and Biomedical Engineering“…[Introduction to Cell Mechanics and Mechanobiology] touches on all the main current techniques used to apply force to cells and to measure the forces exerted by cells….the physics behind them is well explained and derived…The book sets up a good context for why one would want to study mechanobiology and gives some good tips for designing an experiment, taking into account the fundamental differences in biology and engineering practices.”- Yale Journal of Biology and MedicineTable of ContentsPart I. Principles1. Cell Mechanics as a Framework2. Fundamentals of Cell Biology3. Solid Mechanics Primer4. Fluid Mechanics Primer5. Statistical Mechanics PrimerPart II. Practices6. Cell Mechanics in the Laboratory 7. Mechanics of Cellular Polymers8. Polymer Networks and the Cytoskeleton9. Mechanics of the Cell Membrane10. Adhesion, Migration, and Contraction of the Cell11. Mechanotransduction and Intracellular Signaling
£68.39
Taylor & Francis Inc NanoBioMaterials
Book SynopsisThe present book volume presents a holistic view of the aspects of nanobiomaterials incl. their stellar merits and limitations, applications in diverse fields, their futuristic promise in the fields of biomedical science and drug delivery. The federal & regulatory issues on the usage of nanobiomaterials have been assigned due consideration.Table of ContentsApplications of Nano-Based Biomaterials. Nanocoutured Metallic Biomaterials and Surface Functionalization of Titanium-based Alloys for Medical Applications. Graphene-Polymer Nanocomposites for Biomedical Applications. Lipid-based Nanocarriers in Lymphatic Transport of Drugs: Retrospect and Prospects. Nanotechnology in Early Diagnosis of Cancer. Dendrimers: Emerging Anti-Infective Nanomedicines. Production and Utilization of Nanofibers. Fibro-Porous Composite Nano-Biomaterials for Enhanced Bio-Integration. Nanocarriers Mediated Protein Delivery. Nanotechnology-Based Prodrug Conjugates for Site-Specific Antineoplastic Therapy. Osteomyelitis: Therapeutic Management using Nanomedicines.Nanostructured Lipid Carriers-Mediated Methotraxate Delivery Evokes Transcription Factors to Induce Selective Apoptosis in Rheumatoid Arthritis.Superparamagnetic Iron Oxide Nanoparticles for Magnetic Hyperthermia Applications. Development of In-house Nano-hydroxyapatite Particles for Dental Applications.
£166.25
Taylor & Francis Inc Metal Ions in Biological Systems
Book SynopsisOffering an authoritative and timely account by twenty-nine internationally recognized experts, Metal Ions in Biological Systems: Metal Complexes in Tumor Diagnosis and as Anticancer Agents is devoted solely to the vital research area concerning metal complexes in cancer diagnosis and therapy. In fourteen stimulating chapters, the book focuses on diagnostic tools such as magnetic resonance imaging (MRI), luminescent probes, and radiopharmaceuticals, including radiometallo-labeled peptides and assesses the role of metal ions, especially iron, in the action of antibiotics employed in anticancer chemotherapy.Trade Review"This is one of two recent volumes in a most successful series publishes since 1973 and which enjoys world renown and respect as both reference and as training material; the current volume is no exception. … [T]his is a gem of a book for both newcomers and established researchers in the field; long may they continue!" - Applied Organometallic Chemistry, 2005Promo CopyTable of ContentsMagnetic Resonance Contrast Agents for Medical and Molecular Imaging. Luminescent Lanthanide Probes as Diagnostic and Therapeutic Tools. Radio-Lanthanides in Nuclear Medicine. RadioMetallo-Labeled Peptides in Tumor Diagnosis and Therapy. Cisplatin and Related Anticancer Drugs. Recent Advances and Insights. The Effect of Cytoprotective Agents in Platinum Anticancer Therapy. Antitumor Activity of Trans-Platinum Species. Polynuclear Platinum Drugs. Platinum(IV) Anticancer Complexes. Ruthenium Anticancer Drugs. Antitumor Titanium Compounds and Related Metallocenes. Gold Complexes as Antitumor Agents. Gallium and Other Main Group Metal Compounds as Antitumor Agents. Metal Ion Dependent Antibiotics in Chemotherapy.
£285.00
CABI Publishing Modelling SoilBiosphere Interactions
Book SynopsisSoils interact with the biological environment in a number of ways. Our understanding of these interactions can often be enhanced by computer modelling. The primary function of this book is to introduce basic modelling skills and to show how even complex problems in the relationship between soil and the biosphere can be solved using modelling packages. The author presents numerous examples using ModelMaker, an easily learnt software package. Only basic mathematical skills are expected of the reader. A demo of ModelMaker is available on CD from Cherwell ScientificTable of Contents1: Introduction 2: Nitrogen Transformation in Soil 3: Modelling kinetics 4: Nitrification 5: Denitrification 6: C/N transformations in soil organic matter 7: Soil Temperature 8: Dynamics in space and time 9: Volumetric heat capacity and thermal conductivity 10: Heat flow models 11: Soil Water 12: Potential concept 13: Hydraulic conductivity 14: Basic water flow model 15: Other boundary conditions 16: Infiltrability 17: Soil Energy Balance 18: Soil temperature-moisture model 19: Radiation balance 20: Water vapour movement 21: Plant Growth 22: Conceptual plant growth model 23: Photosynthesis 24: Plant growth-substrate relationships 25: Environmental factors 26: Leaching 27: Transport processes 28: Leaching models 29: Final Comments
£111.20
Cambridge University Press Electric Brain Signals
Book SynopsisIt is common to study the electric activity of neurons by measuring the electric potential in the extracellular space of the brain. However, interpreting such measurements requires knowledge of the biophysics underlying the electric signals. Written by leading experts in the field, this volume presents the biophysical foundations of the signals as well as results from long-term research into biophysics-based forward-modeling of extracellular brain signals. This includes applications using the open-source simulation tool LFPy, developed and provided by the authors. Starting with the physical theory of electricity in the brain, this book explains how this theory is used to simulate neuronal activity and the resulting extracellular potentials. Example applications of the theory to model representations of real neural systems are included throughout, making this an invaluable resource for students and scientists who wish to understand the brain through analysis of electric brain signals, using biophysics-based modeling.
£52.24
Cambridge University Press Theoretical Biology of the Cell
Book Synopsis
£59.99
Springer-Verlag New York Inc. Membrane Lipids
Book SynopsisThis detailed book explores examples of current in vitro and in silico techniques that are at the forefront of lipid membrane research today. Beginning with methods and strategies associated with the creation and use of lipid membrane models in various research settings, the volume continues with electrical impedance spectroscopy strategies and methods to identify how ions and proteins interact with model lipid bilayers, guidance on lipid bilayer in silico molecular dynamics modeling, novel techniques to explore lipid bilayer characteristics using neutron scattering, IR spectroscopy, and atomic force microscopy (AFM), as well as unique fluorescence techniques. Written in the highly successful Methods in Molecular Biology series style, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Table of Contents1. Methods for Forming Giant Unilamellar Fatty Acid Vesicles Lauren A. Lowe, Daniel W.K. Loo, and Anna Wang 2. Preparing Ion Channel Switch Membrane-Based Biosensors Amani Alghalayini, Charles G. Cranfield, Bruce A. Cornell, and Stella M. Valenzuela 3. Langmuir-Schaefer Deposition to Create an Asymmetrical Lipopolysaccharide Sparsely-Tethered Lipid Bilayer Charles G. Cranfield, Anton Le Brun, Alvaro Garcia, Bruce A. Cornell, and Stephen A. Holt 4. Electrochemical Impedance Spectroscopy as a Convenient Tool to Characterize Tethered Bilayer Membranes Tadas Penkauskas, Filipas Ambrulevičius, and Gintaras Valinčius 5. Measuring Voltage-Current Characteristics of Tethered Bilayer Lipid Membranes to Determine the Electro-Insertion Properties of Analytes Hadeel Alobeedallah, Bruce A. Cornell, and Hans Coster 6. Measuring Activation Energies for Ion Transport Using Tethered Bilayer Lipid Membranes (tBLMs) Hadeel Alobeedallah, Bruce A. Cornell, and Hans Coster 7. Determining the Pore Size of Multimeric Peptide Ion Channels Using Cation Conductance Measures of Tethered Bilayer Lipid Membranes Lissy M. Hartmann, Alvaro Garcia, Evelyne Deplazes, and Charles G. Cranfield 8. De-Insertion Current Analysis of Pore-Forming Peptides and Proteins Using Gold Electrode-Supported Lipid Bilayer Kan Shoji 9. Drug Meets Monolayer: Understanding the Interactions of Sterol Drugs with Models of the Lung Surfactant Monolayer Using Molecular Dynamics Simulations Sheikh I. Hossain, Mohammad Z. Islam, Suvash C. Saha, and Evelyne Deplazes 10. Establishing a Lipid Bilayer for Molecular Dynamics Simulations Robby Manrique 11. Initiating Coarse-Grained MD Simulations for Membrane-Bound Proteins Amanda Buyan and Ben Corry 12. Small Angle Neutron Scattering of Liposomes: Sample Preparation to Simple Modeling Kathleen Wood 13. Time-Resolved SANS to Measure Monomer Inter-Bilayer Exchange and Intra-Bilayer Translocation Michael H.L. Nguyen, Mitchell DiPasquale, Stuart R. Castillo, and Drew Marquardt 14. Identifying Membrane Lateral Organization by Contrast-Matched Small Angle Neutron Scattering Mitchell DiPasquale, Michael H.L. Nguyen, Stuart R. Castillo, Frederick A. Heberle, and Drew Marquardt 15. Using refnx to Model Neutron Reflectometry Data from Phospholipid Bilayers Stephen A. Holt, Tara E. Oliver, and Andrew R.J. Nelson 16. Surface-Enhanced Infrared Absorption Spectroscopy (SEIRAS) to Probe Interfacial Water in Floating Bilayer Lipid Membranes (fBLMs) Kinga Burdach, Damian Dziubak, and Slawomir Sek 17. Manipulation of Lipid Membranes with Thermal Stimuli Karolina Spustova, Lin Xue, Ruslan Ryskulov, Aldo Jesorka, and Irep Gözen 18. Analyzing Morphological Properties of Early-Stage Toxic Amyloid β Oligomers by Atomic Force Microscopy Dusan Mrdenovic, Jacek Lipkowski, and Piotr Pieta 19. Formation and Nanoscale Characterization of Asymmetric Supported Lipid Bilayers Containing Raft-Like Domains Romina F. Vázquez, Erasmo Ovalle-García, Armando Antillón, Iván Ortega-Blake, Carlos Muñoz-Garay, and Sabina M. Maté 20. Rapid FLIM Measurement of Membrane Tension Probe Flipper-TR Elvis Pandzic, Renee Whan, and Alex Macmillan 21. Bacterial Dye Release Measures in Response to Antimicrobial Peptides Srikanth Dumpati and Debarun Dutta 22. Quantitative Measurements of Membrane Lipid Order in Yeast and Fungi Maria Makarova and Dylan M. Owen
£161.99
Cambridge University Press Thermodynamics and Statistical Mechanics of Macromolecular Systems
Book SynopsisReviewing statistical mechanics concepts and tools necessary for the study of structure formation processes in macromolecular systems, this book provides insight into modern research at this interface between physics, chemistry, biology, and nanotechnology. It is an excellent reference for graduate students and researchers.Trade Review'The clarity of exposition supports the author's goal with respect to his view. In fact, as stated in the preface and outline of his work, he wished to overcome the frustration for the present contradicting and inconclusive literature in this field. The richness of specific examples also supports the book scope. The approach to modelling is also clearly described. … this book could be suitable also for non-experts in the field, due to its precise exposition of the subjects. I would recommend this book to people from different scientific backgrounds: starting from physics to biology, biochemistry and many others. The work by Bachmann should also be considered as … an acquisition, whose value is long-lasting. Finally, the exhaustive treatment contained in [this book] might also constitute a good support for defining future research paths and projects, which have now a wide spectrum of applications.' Marco Casazza, Contemporary PhysicsTable of ContentsPreface and outline; 1. Introduction; 2. Statistical mechanics: a modern review; 3. The complexity of minimalistic lattice models for protein folding; 4. Monte Carlo and chain growth methods for molecular simulations; 5. First insights to freezing and collapse of flexible polymers; 6. Crystallization of elastic polymers; 7. Structural phases of semiflexible polymers; 8. Generic tertiary folding properties of proteins in mesoscopic scales; 9. Protein folding channels and kinetics of two-state folding; 10. Inducing generic secondary structures by constraints; 11. Statistical analyses of aggregation processes; 12. Hierarchical nature of phase transitions; 13. Adsorption of polymers at solid substrates; 14. Hybrid protein-substrate interfaces; 15. Concluding remarks and outlook; Notes; References; Index.
£53.99
Cambridge University Press Neuronal Dynamics From Single Neurons to Networks and Models of Cognition
Book SynopsisExploring neuron models, the neural code, decision making and learning, this textbook provides a thorough and up-to-date introduction to computational neuroscience for advanced undergraduate and beginning graduate students. With step-by-step explanations, end-of-chapter summaries and classroom-tested exercises, it is ideal for courses or for self-study.Table of ContentsPreface; Part I. Foundations of Neuronal Dynamics: 1. Introduction; 2. The Hodgkin–Huxley model; 3. Dendrites and synapses; 4. Dimensionality reduction and phase plane analysis; Part II. Generalized Integrate-and-Fire Neurons: 5. Nonlinear integrate-and-fire models; 6. Adaptation and firing patterns; 7. Variability of spike trains and neural codes; 8. Noisy input models: barrage of spike arrivals; 9. Noisy output: escape rate and soft threshold; 10. Estimating models; 11. Encoding and decoding with stochastic neuron models; Part III. Networks of Neurons and Population Activity: 12. Neuronal populations; 13. Continuity equation and the Fokker–Planck approach; 14. The integral-equation approach; 15. Fast transients and rate models; Part IV. Dynamics of Cognition: 16. Competing populations and decision making; 17. Memory and attractor dynamics; 18. Cortical field models for perception; 19. Synaptic plasticity and learning; 20. Outlook: dynamics in plastic networks; Bibliography; Index.
£90.25
John Wiley & Sons Inc Biophysics For Dummies
Book SynopsisThe fun, easy way to get up to speed on biophysics concepts, principles, and practices One of the most diverse of modern scientific disciplines, biophysics applies methods and technologies from physics to the study of biological systems and phenomena, from the human nervous system to soil erosion to global warming.Table of ContentsIntroduction 1 Part I: Getting Started with Biophysics 5 Chapter 1: Welcoming You to the World of Biophysics 7 Chapter 2: Interrogating Biophysics: The Five Ws and One H 19 Chapter 3: Speaking Physics: The Basics for All Areas of Biophysics 25 Part II: Calling the Mechanics to Fix Your Bio — Biomechanics 47 Chapter 4: Bullying Biomechanics with the Laws of Physics 49 Chapter 5: Sitting with Couch Potatoes — Static Equilibrium 77 Chapter 6: Building the Mechanics of the Human Body and Animals 105 Chapter 7: Making The World Go Round With Physics — Dynamics 139 Chapter 8: Looking at Where Moving Objects Go — Kinematics 165 Part III: Making Your Blood Boil — The Physics of Fluids 187 Chapter 9: Understanding the Mechanics of Fluids and Cohesive Forces 189 Chapter 10: Going with the Fluid Flow — Fluid Dynamics 209 Chapter 11: Breaking through to the Other Side — Transport, Membranes, and Porous Material 235 Part IV: Playing the Music Too Loud — Sound and Waves 253 Chapter 12: Examining the Physics of Waves and Sound 255 Chapter 13: Grasping How Animals and Instruments Produce Sound Waves 275 Chapter 14: Detecting Sound Waves with the Ear 293 Chapter 15: Listening to Sound — Doppler Effect, Echolocation, and Imaging 305 Part V: Interacting Subatomic Particles’ Influcence on Biological Organisms 315 Chapter 16: Charging Matter: The Laws of Physics for Electricity, Magnetism, and Electromagnetism 317 Chapter 17: Tapping into the Physics of Radiation 339 Chapter 18: Fighting the Big C — But Not All Radiation Is Bad 359 Chapter 19: Seeing Good Biophysics in the Medical Field 375 Part VI: The Part of Tens 385 Chapter 20: Ten (or So) Tips to Help You Master Your Biophysics Course 387 Chapter 21: Ten Careers for People Studying Biophysics 391 Index 395
£14.44
John Wiley & Sons Inc Encyclopedia Of Biocolloid And Biointerface
Book SynopsisThis encyclopedia uniquely concentrates on biocolloids and biointerfaces rather than the broader field of colloid and interface science.Table of ContentsList of Contributors xxi Preface xxvii 1 Studies On Biocompatible Surface-Active Silica Aerogel and Polyurethane−Siloxane Cross-Linked Structures for Various Surfaces 1K. Seeni Meera, R. Murali Sankar, S. N. Jaisankar, and Asit Baran Mandal 2 Interaction of Anesthetics with Globular Proteins 17Makoto Nishimoto, Michio Yamanaka, and Hitoshi Matsuki 3 Lipid Monolayer and Interaction with Anesthetics 36Yasushi Yamamoto and Keijiro Taga 4 Atomic Force Microscopy for Measuring Interaction Forces in Biological Materials and Cells 59Naoyuki Ishida, Yasuyuki Kusaka, Tomonori Fukasawa, and Hiroyuki Shinto 5 Bacterial Interactions 68Masanori Toyofuku, Yosuke Tashiro, Tomohiro Inaba, and Nobuhiko Nomura 6 2D and 3D Biocompatible Polymers for Biomedical Devices 82Masaru Tanaka 7 Biofilm 94Hisao Morisaki 8 Use of Microorganisms for Complex ORE Beneficiation: Bioflotation as an Example 108Akira Otsuki 9 Biofouling 118Kazuho Nakamura 10 Bioinspired Microemulsions and Their Strategic Pharmacological Perspectives 122Soumik Bardhan, Kaushik Kundu, Gulmi Chakraborty, Bidyut K. Paul, Satya P. Moulik, and Swapan K. Saha 11 Development of Nonfouling Biomaterials 145Ruey-Yug Tsay and Toyoko Imae 12 Surface Characterization of Silver and Fe3O4 Nanoparticles Incorporated into Collagen-based Scaffolds as Biomaterials for Tissue Regeneration: State-of-the-Art and Future Perspectives 161Abhishek Mandal, N. Chandrasekaran, Amitava Mukherjee, and Thothapalli P. Sastry 13 Biomimetic Polymer Aggregates: Self-Assembly Induced by Chemical Reactions 181Eri Yoshida 14 Molecular Interaction in Biomimetics and Biosystems: Chirality and Confinement at Nanodimension 195Nilashis Nandi and Saheb Dutta 15 Softinterface on Biosensing 211Yukichi Horiguchi and Yukio Nagasaki 16 Bioseparation Using Thermoresponsive Polymers 220Kenichi Nagase and Teruo Okano 17 Biosurfactants 231Etsuo Kokufuta 18 Structure and Regulation of the Blood–Brain Barrier 244Yung-Chih Kuo, Chin-Lung Lee, and Jyh-Ping Hsu 19 Boron Tracedrugs as Theranostic Agents for Neutron Dynamic Therapy 255Hitoshi Hori and Hiroshi Terada 20 Carbohydrates as Biocolloids in Nanoscience 260Zaheer Khan, Shokit Hussain, Ommer Bashir, and Shaeel Ahmed Al-Thabaiti 21 High-Strength Poly(Vinyl Alcohol) Hydrogels for Artificial Cartilage 269Atsushi Suzuki and Teruo Murakami 22 Superior Tribological Behaviors of Articular Cartilage and Artificial Hydrogel Cartilage 278Teruo Murakami and Atsushi Suzuki 23 Self-Assembled Cell-Mimicking Vesicles Composed of Amphiphilic Molecules: Structure and Applications 292Swati De and Ranju Prasad Mandal 24 Integrin-Dependent Cell Regulation and its Clinical Application 313Takuya Iyoda, Takuya Matsunaga, and Fumio Fukai 25 Depth Profile of Kr+-Irradiated Chitosan 325Kazunaka Endo 26 Electronic Structure of Chitosan 331Kazunaka Endo 27 Aligned Fibrillar Collagen Matrices 340Ralf Zimmermann, Jens Friedrichs, Babette Lanfer, Uwe Freudenberg, and Carsten Werner 28 Colloidal Crystallization 355Tsuneo Okubo 29 Dielectric Properties of Biological Macromolecules and Biomolecule–Water Interfaces 380Brandon Campbell, Lin Li, and Emil Alexov 30 NMR of Drug Delivery Coupled with Lipid Membrane Dynamics 391Emiko Okamura 31 Stimulus-Responsive Intelligent Drug Delivery System Based on Hydroxyapatite-Related Materials 403Makoto Otsuka 32 Drying Structure 412Tsuneo Okubo 33 Electrophoretic Mobility of Colloidal Particles 430Hiroyuki Ohshima 34 Electrostatic Interaction Between Colloidal Particles 439Hiroyuki Ohshima 35 Physicochemical Properties and Clinical Applications Of Surfactant-Free Emulsions Prepared with Electrolytic Reduction IonWater (ERI) 451Ken-ichi Shimokawa and Fumiyoshi Ishii 36 Steady-State Coupling in Enzyme Membrane 459Kazuo Nomura 37 Evaluation of Zeta-Potential of Individual Exosomes Secreted from Biological Cells Using a Microcapillary Electrophoresis Chip 469Takanori Akagi and Takanori Ichiki 38 Flocculation Dynamics on the Basis of Collision-Limited Analysis 474Yasuhisa Adachi 39 Anisotropic Gel Formation Induced by Dialysis 487Toshiaki Dobashi and Takao Yamamoto 40 Gels 498Etsuo Kokufuta 41 Gel Crystals 514Tsuneo Okubo 42 Oleic Acid-Based Surfactants as Cost-Effective Gemini Surfactants 529Kenichi Sakai and Masahiko Abe 43 Synthesis and Properties of Heterocyclic Cationic Gemini Surfactants 539Avinash Bhadani, Sukhprit Singh, Hideki Sakai, and Masahiko Abe 44 Functional Hydrogel Microspheres 554Daisuke Suzuki, Takuma Kureha, and Koji Horigome 45 Hydrophilic–Lipophilic Balance (HLB): Classical Indexation and Novel Indexation of Surfactant 570Yuji Yamashita and Kazutami Sakamoto Index 000 List of Contributors xix Preface xxv 46 Insulin Fibrillation and Role of Peptides and Small Molecules in its Inhibition Process 575Victor Banerjee and K.P. Das 47 Interfacial Water Between Charge-Neutralized Polymer and Liquid Water 592Hiromi Kitano and Makoto Gemmei-Ide 48 Langmuir Monolayer Interaction of Perfluorooctylated Long-Chain Alcohols With Biomembrane Constituents 597Hiromichi Nakahara and Osamu Shibata 49 Affinity Latex 609Haruma Kawaguchi 50 Latex Diagnosis 614Haruma Kawaguchi 51 Light Scattering and Electrophoretic Light Scattering of Biopolymers 619Etsuo Kokufuta 52 Impact of Line Tension on Colloidal Systems 628Hiroki Matsubara, Takanori Takiue, and Makoto Aratono 53 Liquid Structures and Properties of Lipids 642Makio Iwahashi 54 Birefringence in Lipid Bilayer Membranes 661Kiyoshi Mishima 55 Surface States of Lipid Monolayers Containing Gangliosides 674Shoko Yokoyama 56 Liponanocapsule: A Nanocapsule Built From a Liposomal Template 684Yuuka Fukui and Keiji Fujimoto 57 Physical Phenomena of Magnetic Suspensions for Application to Bioengineering 690Akira Satoh 58 Ion-Sensing Membrane Electrodes in Study of Surfactant–Biopolymer Interaction 704Sudeshna M. Chatterjea, Koustubh Panda, and Satya P. Moulik 59 Membrane Potential as a Function of Dielectric Constant 721Akihiko Tanioka and Hidetoshi Matsumoto 60 Biophysical Studies of a Micellar Protein α-Crystallin by Fluorescence Methods 737Aritra Chowdhury, Rajat Banerjee, and K.P. Das 61 Modeling Muscle Contraction Mechanism in Accordance with Sliding-Filament Theory 753Toshio Mitsui and Hiroyuki Ohshima 62 Nanocarriers of Functional Materials From Amino Acid Surfactants 771Geetha Baskar, S. Angayarkanny, and Asit Baran Mandal 63 Syntheses of Metallic Nanocolloids and the Quenching Abilities of Reactive Oxygen Species 784Yukihide Shiraishi and Naoki Toshima 64 Silver and Gold Nanocomposites: Amino Acid Sidechain Effect on Morphology 790Zoya Zaheer and Rafiuddin 65 Nanogel, an Internally Networked Poly(Amino Acid) Nanoparticle for pH-Responsive Delivery 799Jong-Duk Kim and Chan Woo Park 66 Strategies of Metal Nanoparticles for Nanobiology 812Daisuke Matsukuma and Hidenori Otsuka 67 On-Chip Electrophoresis for Evaluating Zeta-Potential of Nanoliposomes 821Takanori Akagi and Takanori Ichiki 68 Phase Separation in Phospholipid Bilayers Induced by Cholesterol 825Nobutake Tamai, Masaki Goto, and Hitoshi Matsuki 69 Phase Separation Phenomena in Drug Systems 841Andleeb Z. Naqvi and Kabir-ud-Din 70 Bilayer Imaging of Phosphatidylcholines by High-Pressure Fluorometry 860Masaki Goto, Nobutake Tamai, and Hitoshi Matsuki 71 Physiological and Molecular Aspects of Mechanisms Involved in Plant Response to Salt Stress 870Xiaoli Tang, Xingmin Mu, Hongbo Shao, Hongyan Wang, and Marian Brestic 72 Interfacial Phenomena of Pulmonary Surfactant Preparations 885Hiromichi Nakahara, Sannamu Lee, and Osamu Shibata 73 Using Thin Liquid Film for Study of Pulmonary Surfactants 905Dotchi Exerowa, Roumen Todorov, and Dimo Platikanov 74 Probing Receptor–Ligand Interactions on a Single Molecule Level Using Optical Tweezers 915Tim Stangner, Carolin Wagner, Christof Gutsche, Konstanze Stangner, David Singer, Stefano Angioletti-Uberti, and Friedrich Kremer 75 AC Electrokinetics of Concentrated Suspensions of Soft and Hairy Nanoparticles: Model and Experiments 933Silvia Ahualli, Angel V. Delgado, Félix Carrique, and María Luisa Jimenez 76 Electrophoretic Behavior of pH-Regulated Soft Biocolloids 946Li-Hsien Yeh and Jyh-Ping Hsu 77 Electrophoretic Mobility of Soft Particles 961Kimiko Makino and Hiroyuki Ohshima 78 Potential Distribution Around a Hard Particle and a Soft Particle 970Hiroyuki Ohshima 79 Soil Interfacial Electrical Phenomena 979Munehide Ishiguro 80 Pharmaceutical Solid–Water Interface Phenomena Measured by Near-Infrared Spectroscopy 994Yusuke Hattori and Makoto Otsuka 81 Colloid Stability of Biocolloidal Dispersions 1004Tharwat Tadros 82 Stability Ratio and Early-Stage Aggregation Kinetics of Colloidal Dispersions 1014Hiroyuki Ohshima 83 Catanionic Surfactants: Novel Surrogates of Phospholipids 1120Kausik Manna and Amiya Kumar Panda 84 Phase Behavior of Natural-Sourced Surfactant Systems 1144Kenji Aramaki 85 Surfactants and Biosurfactants 1151Youichi Takata 86 Effect of Additives on Self-Association and Clouding Phenomena of Various Surface-Active Drugs 1156Md. Sayem Alam and Asit Baran Mandal 87 Thermodynamic Analysis of Partial Molar Volume in Biocolloidal Systems 1171Michio Yamanaka, Hideyuki Maekawa, Tamaki Yasui, and Hitoshi Matsuki 88 Van Der Waals Interaction Between Colloidal Particles 1187Hiroyuki Ohshima 89 Wormlike Micelles with Nonionic Surfactants 1195Rekha Goswami Shrestha, Kenji Aramaki, Hideki Sakai, and Masahiko Abe Index
£428.36
John Wiley & Sons Inc Biomechanics For Dummies
Book SynopsisA thorough explanation of the tenets of biomechanics At once a basic and applied science, biomechanics focuses on the mechanical cause-effect relationships that determine the motions of living organisms. Biomechanics for Dummies examines the relationship between biological and mechanical worlds.Table of ContentsIntroduction 1 About This Book 1 Foolish Assumptions 2 Icons Used in This Book 3 Beyond the Book 3 Where to Go from Here 4 Part I: Getting Started with Biomechanics 5 Chapter 1: Jumping Into Biomechanics 7 Analyzing Movement with Biomechanics 7 Mechanics 8 Bio 9 Expanding on Mechanics 10 Describing motion with kinematics 11 Causing motion with kinetics 13 Putting Biomechanics to Work 14 Chapter 2: Reviewing the Math You Need for Biomechanics 15 Getting Orientated 16 Brushing Up on Algebra 17 Following the order of operations 17 Defining some math operations 19 Isolating a variable 20 Interpreting proportionality 22 Looking for the Hypotenuse 23 Using the Pythagorean theorem 24 De-tricking trigonometric functions: SOH CAH TOA 26 Unvexing Vector Quantities 31 Resolving a vector into components 33 Composing a vector from components 35 Chapter 3: Speaking the Language of Biomechanics 37 Measuring Scalars and Vectors 38 Standardizing a Reference Frame 39 Directing your attention to locations of the body 40 Referencing planes and axes 40 Describing Movement: Kinematics 42 Typecasting motion: Linear, angular, and general 42 Describing how far: Distance and displacement 43 Describing how fast: Speed and velocity 44 Changing velocity: Acceleration 45 Pushing and Pulling into Kinetics 45 Forcing yourself to understand Newton’s laws of motion 47 Using the impulse–momentum relationship 49 Working with Energy and Power 49 Mechanical work 49 Mechanical energy 50 Mechanical power 51 Turning Force into Torque 51 Dealing with Measurement Units 51 Using the Neuromusculoskeletal System to Move 52 The skeletal system 53 The muscular system 53 The nervous system 55 Part II: Looking At Linear Mechanics 57 Chapter 4: Making Motion Change: Force 59 Pushing and Pulling: What Is Force? 59 Working with Force Vectors 65 Using the force components to find the resultant 66 Resolving a force into components 68 Classifying Forces 69 Contact and noncontact forces 69 Internal and external forces 70 Feeling the Pull of Gravity 74 Slipping, Sliding, and Staying Put: Friction Is FμN 76 Materials do matter: The coefficient of friction ( μ ) 80 Squeezing to stick: Normal reaction force (N) 81 Chapter 5: Describing Linear Motion: Linear Kinematics 83 Identifying Position 84 Describing How Far a Body Travels 85 Distance.85 Displacement 86 Describing How Fast a Body Travels 88 Speed 89 Velocity 90 Momentum 92 Speeding Up or Slowing Down: Acceleration 92 Constant acceleration 95 Projectile motion 95 Chapter 6: Causing Linear Motion: Linear Kinetics 103 Clarifying Net Force and Unbalanced Force 103 Newton’s First Law: The Law of Inertia 106 Newton’s Third Law: The Law of Equal and Opposite Action–Reaction 107 Newton’s Second Law: The Law of Acceleration 109 Deriving the impulse–momentum relationship from the law of acceleration 112 Applying the impulse–momentum relationship for movement analysis 114 Chapter 7: Looking At Force and Motion Another Way: Work, Energy, and Power 119 Working with Force 120 Energizing Movement 122 Kinetic energy 123 Potential energy 124 Conserving Mechanical Energy 128 Powering Better Performance 130 The Work–Energy Relationship 131 Part III: Investigating Angular Mechanics 137 Chapter 8: Twisting and Turning: Torques and Moments of Force 139 Defining Torque 140 Lining up for rotation: The moment arm of a force 141 Calculating the turning effect of a force 142 Measuring Torque 144 Muscling into torque: How muscles serve as torque generators 145 Resisting torque: External torques on the body 148 Expanding on Equilibrium: Balanced Forces and Torques 149 Locating the Center of Gravity of a Body 152 Chapter 9: Angling into Rotation: Angular Kinematics 157 Measuring Angular Position 157 Describing How Far a Body Rotates 160 Angular distance 161 Angular displacement 162 Describing How Fast a Body Rotates 163 Angular speed.163 Angular velocity 164 Speeding Up or Slowing Down: Angular Acceleration 165 Relating Angular Motion to Linear Motion 167 Angular displacement and linear displacement 168 Angular velocity and linear velocity 169 Angular acceleration and linear acceleration 171 Chapter 10: Causing Angular Motion: Angular Kinetics 173 Resisting Angular Motion: The Moment of Inertia 174 The moment of inertia of a segment174 The moment of inertia of the whole body 178 Considering Angular Momentum 180 Angular momentum of a rigid body 180 Angular momentum of the human body when individual segments rotate 181 A New Angle on Newton: Angular Versions of Newton’s Laws 181 Maintaining angular momentum: Newton’s first law.182 Changing angular momentum: Newton’s second law 186 Equal but opposite: Newton’s third law189 Changing Angular Momentum with Angular Impulse 191 Chapter 11: Fluid Mechanics 193 Buoyancy: Floating Along 193 Considering Force Due to Motion in Fluid 197 Causing drag in a fluid 198 Causing lift in a fluid 201 Part IV: Analyzing the “Bio” of Biomechanics 205 Chapter 12: Stressing and Straining: The Mechanics of Materials 207 Visualizing Internal Loading of a Body 208 Applying Internal Force: Stress 210 Normal stress 212 Shear stress 217 Responding to Internal Force: Strain 219 Determining tensile strain 221 Determining compressive strain 221 Determining shear strain 222 Straining from Stress: The Stress–Strain Relationship 223 Give and go: Behaving elastically 224 Give and stay: Behaving plastically 224 Chapter 13: Boning Up on Skeletal Biomechanics 227 What the Skeletal System Does 228 How Bones Are Classified 228 The Materials and Structure of Bones 230 Materials: What bones are made of 231 Structure: How bones are organized 232 Connecting Bones: Joints 234 Immovable joints 234 Slightly movable joints 234 Freely movable joints 235 Growing and Changing Bone 237 Changing bone dimensions 238 Stressing bone: The effects of physical activity and inactivity 239 Chapter 14: Touching a Nerve: Neural Considerations in Biomechanics 247 Monitoring and Controlling the Body: The Roles of the Nervous System 248 Outlining the Nervous System 248 The central nervous system 250 The peripheral nervous system 250 Zeroing In on Neurons 251 Parts of neurons 251 Types of neurons 251 Controlling Motor Units 259 Motor unit recruitment 261 Rate coding 261 Chapter 15: Muscling Segments Around: Muscle Biomechanics 263 Characterizing Muscle 263 Seeing How Skeletal Muscles Are Structured 265 The macrostructure of muscles 266 The microstructure of muscle fibers.268 Comparing Types of Muscle Activity 270 Isometric activity 271 Concentric activity 272 Eccentric activity 272 Producing Muscle Force 274 Relating muscle length and tension 274 Relating muscle velocity and tension277 Stretching before Shortening: The Key to Optimal Muscle Force 279 Part V: Applying Biomechanics 283 Chapter 16: Eyeballing Performance: Qualitative Analysis 285 Serving as a Movement Analyst 286 Evaluating the Performance 287 Identifying the goal of the movement 287 Specifying the mechanical objective 289 Determining whether the goal has been reached 290 Troubleshooting the Performance 293 Constraints on performance 293 Technique errors 294 Pitching by the phases 298 Intervening to Improve the Performance 302 Adapting the constraints on throwing performance 302 Refining technique 303 Chapter 17: Putting a Number on Performance: Quantitative Analysis 305 Converting Continuous Data to Numbers 305 Measuring Kinematics: Motion-Capture Systems 306 Collecting kinematic data 307 Processing kinematic data 308 Measuring Kinetics: Force Platform Systems 310 Collecting kinetic data 310 Processing kinetic data 312 Recording Muscle Activity: Electromyography 313 Collecting the electromyogram 314 Processing the electromyogram 315 Chapter 18: Furthering Biomechanics: Research Applications 319 Exercising in Space 319 Repairing the Anterior Cruciate Ligament 320 Running Like Our Ancestors 322 Protecting Our Beans: Helmet Design 324 Balancing on Two Legs: Harder Than You Think 326 Chapter 19: Investigating Forensic Biomechanics: How Did It Happen? 329 Collecting Information for a Forensic Biomechanics Analysis 330 Witness accounts 330 Police incident investigation reports 331 Medical records 331 Determining the Mechanism of Injury 332 Evaluating Different Scenarios 335 Ending up on the far side of the road 335 Landing in water with a broken jaw 336 Part VI: The Parts of Tens 339 Chapter 20: Ten Online Resources for Biomechanics 341 The Exploratorium 341 The Physics Classroom 341 Coaches Info 342 Textbook-Related Websites 343 Topend Sports 343 Dr. Mike Marshall’s Pitching Coach Services 343 Waterloo’s Dr. Spine, Stuart McGill 344 Skeletal Bio Lab 345 Biomch-L 345 American Society of Biomechanics 346 Chapter 21: Ten Things You May Not Know about Biomechanics 347 Looking at How Biomechanics Got Its Start 347 Adding Realism to Entertainment 348 Developing Safer Motor Vehicles 348 Improving the On-Shelf Quality of Fruits and Vegetables 349 Fitting Footwear to the Activity 350 Banning Biomechanically Improved Sport Techniques 351 Re-Creating Dinosaurs 352 Designing Universally and Ergonomically 352 Giving a Hand to Prosthetics Design 353 Losing Weight to Help Your Joints 354 Chapter 22: Ten Ways to Succeed in Your Biomechanics Course 355 Go to Class and Ask Questions 355 Read the Textbook 356 Do the Problems and Review Questions at the End of the Chapter 357 Create Flashcards 357 Go to Office Hours 358 Form a Study Group with Classmates 358 Accept and Apply Newton as the Foundation of Movement Analysis 359 Talk Fluent Biomechanics with Your Classmates 359 Volunteer for Research Projects 360 Attend a Biomechanics Conference 361 Index 363
£15.29
John Wiley & Sons Inc Introduction to Biological Physics for the Health
Book SynopsisA thoroughly updated and extended new edition of this well-regarded introduction to the basic concepts of biological physics for students in the health and life sciences. Designed to provide a solid foundation in physics for students following health science courses, the text is divided into six sections: Mechanics, Solids and Fluids, Thermodynamics, Electricity and DC Circuits, Optics, and Radiation and Health. Filled with illustrative examples, Introduction to Biological Physics for the Health and Life Sciences, Second Edition features a wealth of concepts, diagrams, ideas and challenges, carefully selected to reference the biomedical sciences. Resources within the text include interspersed problems, objectives to guide learning, and descriptions of key concepts and equations, as well as further practice problems. NEW CHAPTERS INCLUDE: Optical Instruments Advanced Geometric Optics Thermodynamic Processes HeTable of ContentsI Mechanics 1 Chapter 1 Kinematics 3 Chapter 2 Force and Newton’s Laws of Motion 17 Chapter 3 Motion in a Circle 31 Chapter 4 Statics 37 Chapter 5 Energy 47 Chapter 6 Momentum 61 Chapter 7 Simple Harmonic Motion 69 Chapter 8 Waves 79 Chapter 9 Sound and Hearing 91 II Solids and Fluids 107 Chapter 10 Elasticity: Stress and Strain 109 Chapter 11 Pressure 119 Chapter 12 Buoyancy 133 Chapter 13 Surface Tension and Capillarity 141 Chapter 14 Fluid Dynamics of Non-viscous Fluids 149 Chapter 15 Fluid Dynamics of Viscous Fluids 159 Chapter 16 Molecular Transport Phenomena 165 III Thermodynamics 171 Chapter 17 Temperature and the Zeroth Law 173 Chapter 18 Ideal Gases 185 Chapter 19 Phase and Temperature Change 199 Chapter 20 Water Vapour and the Atmosphere 213 Chapter 21 Heat Transfer 227 Chapter 22 Thermodynamics and the Body 239 Chapter 23 Thermodynamic Processes in Ideal Gases 249 Chapter 24 Heat Engines and Entropy 263 Chapter 25 Energy Availability and Thermodynamic Potentials 279 IV Electricity and DC Circuits 293 Chapter 26 Static Electricity 295 Chapter 27 Electric Force and Electric Field 301 Chapter 28 Electrical Potential and Energy 311 Chapter 29 Capacitance 323 Chapter 30 Direct Currents and DC Circuits 333 Chapter 31 Time Behaviour of RC Circuits 351 V Optics 359 Chapter 32 The Nature of Light 361 Chapter 33 Geometric Optics 375 Chapter 34 The Eye and Vision 393 Chapter 35 Wave Optics 411 Chapter 36 Advanced Geometric Optics 429 Chapter 37 Optical Instruments 449 Chapter 38 Atoms and Atomic Physics 463 Chapter 39 The Nucleus and Nuclear Physics 475 Chapter 40 Production of Ionising Radiation 485 Chapter 41 Interactions of Ionising Radiation 499 Chapter 42 Biological Effects of Ionising Radiation 509 Chapter 43 Medical Imaging 519 Chapter 44 Magnetism and MRI 525 Appendices 550 Appendix A Physical Constants 551 Appendix B Basic Maths and Science Skills 553 Appendix C Answers to Odd Numbered Problems 565 Selected Further Reading 576 Index 579
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