Biophysics Books

Book SynopsisDeals with the major terrestrial, algal, and siliceous indicators used in paleolimnology. This title is of interest to seasoned practitioners as well as newcomers to the area of paleolimnology.Trade Review"Volume 3 will be of particular interest to paleolimnologists approaching the subject from the biological or limnological standpoint; some of the most important indicators used by paleolimnologists including pollen analysis, plant macrofossils, charcoal, diatoms, chrysophytes, phytoliths, biogenic silica and pigments. These chapters will become essential citations in the methods sections of future papers." (Philip Barker, Dept. of Geography, Institute of Environmental and Natural Sciences, Lancaster University, UK in Journal of Paleolimnology, 30:4)Table of ContentsPreface. The Editors. Aims & Scope of Developments in Paleoenvironmental Research Book Series. Editors and Board of Advisors of Developments in Paleoenvironmental Research Book Series. Contents of Volumes 1 to 4. Safety Considerations and Caution. Dedication. List of Contributors. 1. Using biology to study long-term environmental change; J.P. Smol, et al. 2. Pollen; K.D. Bennett, K.J. Willis. 3. Conifer stomata; G.M. MacDonald. 4. Plant macrofossils; H.H. Birks. 5. Charcoal as a fire proxy; C. Whitlock, C.P.S. Larsen. 6. Non-pollen palynomorphs; B. van Geel. 7. Protozoa: testate amoebae; L. Beyens, R. Meisterfeld. 8. Diatoms; R.W. Battarbee, et al. 9. Chrysophyte scales and cysts; B.A. Zeeb, J.P. Smol. 10. Ebridians; A. Korhola, J.P. Smol. 11. Phytoliths; D.R. Piperno. 12. Freshwater sponges; T.M. Frost. 13. Siliceous protozoan plates and scales; M.S.V. Douglas, J.P. Smol. 14. Biogenic silica; D.J. Conley, C.L. Schelske. 15. Sedimentary pigments; P.R. Leavitt, D.A. Hodgson. Glossary, Acronyms and Abbreviations. Subject Index.

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Book SynopsisPrinciples of Biophysical Inquiry.- Introduction: To the Student First Edition.- Philosophy and Practice of Biophysical Study.- Overview of the Biological System Under Study.- Physical Thoughts, Biological Systems The Application of Modeling Principles to Understanding Biological Systems.- Probability and Statistics.- Foundations.- Energy and Force The Prime Observables.- Biophysical Forces in Molecular Systems.- Physical Principles: Quantum Mechanics.- Chemical Principles.- Measuring the Energy of a System: Energetics and the First Law of Thermodynamics.- Entropy and the Second Law of Thermodynamics.- Which Way Is That System Going? The Gibbs Free Energy.- The Thermodynamics of Phase Equilibria.- Building a Model of Biomolecular Structure.- Water: A Unique Solvent and Vital Component of Life.- IonSolvent Interactions.- IonIon Interactions.- Lipids in Aqueous Solution.- Macromolecules in Solution.- Molecular Modeling Mapping Biochemical State Space.- The Electrified Interphase.- Function and Action Biological State Space.- Transport A Non-equilibrium Process.- Flow in a Chemical Potential Field: Diffusion.- Flow in an Electric Field: Conduction.- Forces Across Membranes.- Kinetics Chemical Kinetics.- Dynamic Bioelectrochemistry Charge Transfer in Biological Systems.- Methods for the Measuring Structure and Function.- Separation and Characterization of Biomolecules Based on Macroscopic Properties.- Analysis of Molecular Structure with Electronic Spectroscopy.- Molecular Structure from Scattering Phenomena.- Analysis of Structure Microscopy.- Epilogue.- Physical Constants.Table of ContentsPREFACE PART I: Principles of Biophysical Inquiry Chapter 1 Introduction: “To the Student” Chapter 2 Philosophy and Practice of Biophysical Study Chapter 3 Overview of the Biological System Under Study – Descriptive Models Chapter 4 Physical Thoughts, Biological Systems - The application of modeling principles to understanding biological systems Chapter 5 Probability and Statistics PART II: Foundations Chapter 6 Physical Principles: Energy - The Prime Observable Chapter 7 Biophysical Forces in Molecular Systems Chapter 8 An Introduction to Quantum Mechanics Chapter 9 Chemical Principles Chapter 10 Measuring the Energy of a System: Energetics and the First Law of Thermodynamics Chapter 11 Entropy and the Second Law of Thermodynamics Chapter 12 Which Way Did That System Go? The Gibbs Free Energy Chapter 13 The Thermodynamics of Phase Equilibria PART III: Building a Model of Biomolecular Structure Chapter 14 Water: A Unique Structure, A Unique Solvent Chapter 15 Ion-Solvent Interactions Chapter 16 Ion-Ion Interactions Chapter 17 Lipids in Aqueous Solution Chapter 18 Macromolecules in Solution Chapter 19 Molecular Modeling - Mapping Biochemical State Space Chapter 20 The Electrified Interphase PART IV: Function and Action Biological State Space Chapter 21 Transport and Kinetics: Processes Not at Equilibrium Chapter 22 Flow in a Chemical Potential Field: Diffusion Chapter 23 Flow in an Electrical Field: Conduction Chapter 24 Forces Across Membranes Chapter 25 Kinetics - Chemical Kinetics Chapter 26 Bioelectrochemistry – Charge Transfer in Biological Systems PART V: Methods for the Measuring Structure and Function Chapter 27 Separation and Characterization of Biomolecules Based on Macroscopic Properties (with Kristin E. Bergethon) Chapter 28 Determining Structure by molecular interactions with photons: Electronic Spectroscopy (with Kristin Bergethon) Chapter 29 Determining Structure by molecular interactions with photons: ScatteringPhenomena Chapter 30 Analysis of Structure – Microscopy Chapter 31 Epilogue Chapter 32 Physical Constants PART VI: APPENDICES Appendix A Review of Mathematical Methods Appendix B Quantum Electrodynamics Appendix C The Pre-Socratic Roots of Modern Science Appendix D The Poisson Function Appendix E Assumptions of a Kinetic Theory of Ideal Gas Behavior Appendix F Determination of a Field from the Potential Appendix G Geometric Optics Appendix H The Compton Effect Appendix I Hamilton's Principle of Least Action/Fermat's Principle of Least Time Appendix J Energy of Interaction between ions Appendix K Derivation of the Statement, Qrev > Qirrev Appendix L Derivation of the Clausius-Clapeyron Equation Appendix M Derivation of the van't Hoff Equation for Osmotic Pressure Appendix N Pseudoforces Appendix O Work of charging and discharging a rigid sphere Appendix P Review of Electrical Circuits Appendix Q Fermi's Golden Rule Appendix R Adiabatic vs non-Adiabatic processes

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Book SynopsisThis book is based on a series of lectures for a course on ionic channels held in Santiago, Chile, on November 17-20, 1984.Table of ContentsI. Methodologies.- 1 Kinetic Models and Channel Fluctuations.- 1. Introduction.- 2. Two-State Channel.- 3. Two Two-State Channels.- 4. Three-State Channel with Three Conductances.- 5. Three-State Channel with Only Two Conductances.- References.- 2 Single-Channel Currents and Postsynaptic Drug Actions.- 1. Introduction.- 2. Channel Gating as a Stochastic Process.- 3. Postsynaptic Channels in the Presence of Drugs.- 4. Reconstructing the Postsynaptic Current.- 5. Macroscopic and Molecular Consequences.- References.- 3 Voltage-Dependent Gating: Gating Current Measurement and Interpretation.- 1. Introduction.- 2. Voltage Gating.- 3. Gating Current Is a Capacitive Current.- 4. Measurement of Gating Currents.- 5. Gating of the Sodium Channel.- References.- 4 Characterizing the Electrical Behavior of an Open Channel via the Energy Profile for Ion Permeation: A Prototype Using a Fluctuating Barrier Model for the Acetylcholine Receptor Channel.- 1. Introduction.- 2. Theory.- 3. Confrontation with Experimental Data for the AChR Channel.- 4. Discussion.- References.- 5 The Use of Specific Ligands to Study Sodium Channels in Muscle.- 1. Introduction.- 2. Molecular Pharmacology of the Sodium Channel in Muscle.- 3. Sodium Channel in Cardiac Muscle: Are All Sodium Channels Alike?.- 4. Surface and Tubular Sodium Channels in Skeletal Muscle.- 5. Models for Sodium Channels in Muscle Membranes.- References.- 6 Isolation of Muscle Membranes Containing Functional Ionic Channels.- 1. Introduction.- 2. Excitation-Contraction Coupling.- 3. Ionic Channels and E-C Coupling.- 4. Isolation of Muscle Membranes.- 5. Concluding Remarks.- References.- 7 Methodologies to Study Channel-Mediated Ion Fluxes in Membrane Vesicles.- 1. Introduction.- 2. Channel-Mediated Tl+ Flux Measured by Fluorescence Quenching.- 3. Channel-Mediated Ion Fluxes Measured by Light Scattering.- References.- 8 Optical Studies on Ionic Channels in Intact Vertebrate Nerve Terminals.- 1. Introduction.- 2. Equivalence of Optical and Electrical Measurements of Membrane Potential.- 3. Optical Recording of Action Potentials from Nerve Terminals of the Frog Xenopus.- 4. Properties of the Action Potential in the Nerve Terminals.- 5. Ionic Basis of the Depolarizing Phase of the Action Potential.- 6. Concluding Remarks.- References.- 9 Optical Detection of ATP Release from Stimulated Endocrine Cells: A Universal Marker of Exocytotic Secretion of Hormones.- 1. Introduction.- 2. Methodological Considerations.- 3. Acetylcholine-Induced ATP Release from Chromaffin Cells: Calcium Dependence.- 4. Nicotinic Receptor Desensitization.- 5. Granular Nature of the Secreted ATP.- 6. ATP Release Evoked by Membrane Depolarization Is Mediated by Activation of Voltage-Gated Calcium Channels.- 7. ATP Release from Collagenase-Isolated Islets of Langerhans.- 8. Conclusion.- 9. Summary.- References.- II. Channels in Biological Membranes.- 10 Mechanotransducing Ion Channels.- 1. Introduction.- 2. Recording SA Channels.- 3. General Characteristics.- 4. Conductance Properties.- 5. Kinetic Properties.- 6. The Model.- 7. Comparing the Model to the Data.- 8. Future Prospects.- References.- 11 Ionic Channels in Plant Protoplasts.- 1. Introduction.- 2. Some Methodological Considerations.- 3. Voltage-Dependent Channels Opened by Hyperpolarization.- 4. Channels Affected by TEA.- 5. Conclusions.- References.- 12 Channels in Kidney Epithelial Cells.- 1. Introduction.- 2. Cell Culture.- 3. Patch-Clamp Methodology.- 4. Potassium Channel Characteristics.- 5. Channel Modulation.- 6. Conclusions.- References.- 13 Channels in Photoreceptors.- 1. Introduction.- 2. Vertebrate Photoreceptors.- 3. Invertebrate Photoreceptors.- References.- 14 Inactivation of Calcium Currents in Muscle Fibers from Balanus.- 1. Introduction.- 2. Methodological Considerations.- 3. Characteristics of Inward Currents.- 4. Mechanism of Inactivation.- References.- 15 Electrophysiological Studies in Endocrine Cells.- 1. Introduction.- 2. Whole-Cell Patch-Clamp Methodology.- 3. Cell Culture.- 4. Ionic Currents in GH3 Cells.- 5. Characteristics of Calcium Channels.- 6. Conclusions.- References.- III. Ionic Channel Reconstitution.- 16 Ion Channel Reconstitution: Why Bother?.- 1. Introduction and Background.- 2. Unexpected Surprises.- 3. Unconstrained Variables.- 4. Unrealized Hopes.- References.- 17 From Brain to Bilayer: Sodium Channels from Rat Neurons Incorporated into Planar Lipid Membranes.- 1. Perspectives and Background.- 2. Electrophysiology without Cells.- 3. A Closer Look at Batrachotoxin-Activated Sodium Channels in Bilayer Membranes.- 4. Looking Ahead.- References.- 18 Ionic Channels in the Plasma Membrane of Sea Urchin Sperm.- 1. Introduction.- 2. Are There Channels in Sea Urchin Sperm?.- 3. Reconstitution Studies with Isolated Sea Urchin Sperm Plasma Membrane.- 4. Channels in the Plasma Membrane of Sea Urchin Sperm: Implications for the Acrosome Reaction.- 5. Are There Receptors to the Egg Jelly in the Sea Urchin Sperm Plasma Membranes?.- 6. Perspectives.- References.- 19 Characterization of Large-Unitary-Conductance Calcium-Activated Potassium Channels in Planar Lipid Bilayers.- 1. Introduction.- 2. Channel Gating.- 3. Channel Conductance and Selectivity.- 4. Conductance of the Calcium-Activated K+ Channels.- 5. Selectivity of the Ca-K Channels.- 6. Blockade of the Ca-K Channels.- 7. Conclusions.- References.- IV. Ionic Channel Modulation.- 20 Metabolic Regulation of Ion Channels.- 1. Introduction.- 2. Second Messengers.- 3. Protein Phosphorylation.- 4. Summary.- References.- 21 The Cell-to-Cell Membrane Channel: Its Regulation by Cellular Phosphorylation.- 1. Introduction.- 2. The Cell-to-Cell Channels Are Up-Regulated by cAMP-Dependent Phosphorylation.- 3. The Cell-to-Cell Channels are Down-Regulated by Tyrosine Phosphorylation.- References.- 22 The ?-Cell Bursting Pattern and Intracellular Calcium.- 1. Introduction.- 2. Role of [Ca2+]i Dependence on Glucose.- 3. A Biophysical/Mathematical Model.- 4. Burst Frequency Depends on the Ratio [free Ca2+]i/[total Ca]i.- 5. Summary.- References.- 23 Neurotrophic Effects of in Vitro Innervation of Cultured Muscle Cells. Modulation of Ca2+-Activated K+ Conductances.- 1. Introduction.- 2. Methodological Considerations.- 3. Innervation and Muscle Cell Electrical Activity.- 4. Conclusions.- References.- V. Ionic Channel Structure, Functions, and Models.- 24 Correlation of the Molecular Structure with Functional Properties of the Acetylcholine Receptor Protein.- 1. Introduction.- 2. The AChR Macromolecule.- 3. Arrangement of Subunits in the AChR Macromolecule.- 4. The AChR Primary Structure, cDNA Recombinant Techniques, and Modeling Receptor Structure.- 5. Immunochemistry of AChR and the Testing of Models.- 6. Voltage-Gated and Agonist-Gated Channels: A Comparison.- 7. Dynamics of AChR and Lipids in the Membrane.- 8. Acetylcholine-Receptor-Controlled Channel Properties.- References.- 25 Amiloride-Sensitive Epithelial Sodium Channels.- 1. Introduction.- 2. Amiloride-Sensitive Na+ Transport Processes.- 3. Characterization of Amiloride-Sensitive Na+ Channels in Intact Epithelia.- 4. Incorporation of Amiloride-Sensitive Na+ Channels into Planar Bilayers.- 5. Concluding Remarks.- References.- 26 A Channel Model for Development of the Fertilization Membrane in Sea Urchin Eggs.- 1. Introduction.- 2. Processes Following Fertilization.- 3. Experimental Basis for Model.- 4. Description of Model.- 5. Equations of Model.- 6. Solutions of Model Equations.- References.

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Book SynopsisThis richly illustrated third edition provides a thorough training in practical mathematical biology and shows how exciting mathematical challenges can arise from a genuinely interdisciplinary involvement with the biosciences.Trade ReviewFrom the reviews: "The 2nd volume of the authors elucidating work highlights a surprisingly broad spectrum of applications in the field of mathematical biology. The sense given to the mathematical texture of thoughts broadens the reader’s insight … . The growing number of specialists in sub-disciplines of mathematical biology will be enjoying the truly concise approach … . It can so be said that the foremost results … might be essential for new interpretations of data … . It is a recommended text for mathematicians … ." (Daniel Gertsch, Bioworld, Issue 2, 2004) From the reviews of the third edition: "This is the second volume of the third edition of Murray’s ‘Mathematical Biology’. … covers a wide variety of problems in pattern formation, each discussed in its biological context. … This volume alone is a large book, with more than 800 pages and a similar number of references. … it is a valuable collection of results from different areas of mathematical biology." (Carlo Laing, New Zealand Mathematical Society Newsletter, Issue 90, April, 2004) "This book, a classical text in mathematical biology, cleverly combines mathematical tools with subject area sciences. The multi-layer way of material presentation makes the book useful for different types of reader including graduate-level students, bioscientists … . it is an enjoyable reading and I recommend it to anyone with serious interest in mathematical modelling." (V.V. Fedorov, Short Book Reviews, Vol. 23 (3), 2003) "This second volume of the third edition of Murray’s Mathematical biology focuses on partial differential equations (spatial models) and their application to the biomedical sciences. … Each chapter deals with its particular topic in great detail, usually focusing on one biological example and the associated mathematical model and results. This volume is not an introductory text … making it extremely useful in graduate courses and for reference." (Trachette L. Jackson, Mathematical Reviews, 2004b) "In this second volume … the development towards specific biological configurations and towards a mechanism for understanding morphogenesis represents an important portion of the work. … chapters deal with attractive topics … . There is an extensive index at the end. … very interesting and strongly recommended." (A. Akutowicz, Zentralblatt MATH, Vol. 1006, 2003) "In this volume it becomes clear that compiling the third edition was a ‘labor of love’. The book has a significantly different feel from the original first edition. … my reaction to the third edition was positive. … The historical and biological overviews have much interesting information. … Certainly, the spicy writing will keep students alert … . In summary, I recommend the new and expanded third edition to any serious young student interested in mathematical biology … ." (Leah Edelstein-Keshet, SIAM Review, Vol. 46 (1), 2004) "Mathematical Biology would be eminently suitable as a text for a final year undergraduate or postgraduate course in mathematical biology … . It is also a good source of examples for courses in mathematical methods … . Mathematical Biology provides a good way into the field and a useful reference for those of us already there. It may attract more mathematicians to work in biology by showing them that there is real work to be done." (Peter Saunders, The Mathematical Gazette, Vol. 90 (518), 2006)Table of ContentsMulti-Species Waves and Practical Applications * Spatial Pattern Formation with Reaction Diffusion Systems * Animal Coat Patterns and Other Practical Applications of Reaction Diffusion Mechanisms * Pattern Formation on Growing Domains: Alligators and Snakes * Bacterial Patterns and Chemotaxis * Mechanical Theory for Generating Pattern and Form in Development * Evolution, Morphogenetic Laws, Developmental Constraints and Teratologies * A Mechanical Theory of Vascular Network Formation * Epidermal Wound Healing * Dermal Wound Healing * Growth and Control of Brain Tumours * Neural Models of Pattern Formation * Geographic Spread and Control of Epidemics * Wolf Territoriality, Wolf-Deer Interaction and Survival

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Book SynopsisI Diffraction and Imaging of Elastically Scattered Electrons.- 1. Basic Kinematic Electron Diffraction.- 2. Dynamic Elastic Electron Scattering I: Bloch Wave Theory.- 3. Dynamic Elastic Electron Scattering II: Multislice Theory.- 4. Dynamic Elastic Electron Scattering III: Other Approaches.- 5. Diffraction and Imaging of Reflected High-Energy Electrons from Bulk Crystal Surfaces.- II Diffraction and Imaging of Inelastically Scattered Electrons.- 6. Inelastic Excitations and Absorption Effect in Electron Diffraction.- 7. Semiclassical Theory of Thermal Diffuse Scattering.- 8. Dynamic Inelastic Electron Scattering I: Bloch Wave Theory.- 9. Reciprocity in Electron Diffraction and Imaging.- 10. Dynamic Inelastic Electron Scattering II: Green's Function Theory.- 11. Dynamic Inelastic Electron Scattering III: Multislice Theory.- 12. Dynamic Inelastic Electron Scattering IV: Modified Multislice Theory.- 13. Inelastic Scattering in High-Resolution Transmission Electron Imaging.- 14. Multiple ITrade Review`This is an excellent and comprehensive book describing the theory of the elastic and inelastic scattering of the electrons by crystals....This book fills a gap in the existing books on electron microscopy because it discusses in considerable depth inelastic scattering in electron diffraction and microscopy...very useful both as a textbook and as a reference book....comprehensive and right up to date...suitable for scientists ranging from research students to real experts in the field.' Journal of Microscopy `Without question this book, particularly the treatment of inelastic scattering, is a noteworthy achievement and a valuable contribution to the literature.' American Scientist Table of ContentsIntroduction. Symbols and Definitions. Diffraction and Imaging of Elastically Scattered Electrons: Basic Kinematical Electron Diffraction. Dynamical Elastic Electron Scattering I: Bloch Wave Theory. Dynamical Elastic Electron Scattering II: Multislice Theory. Dynamical Elastic Electron Scattering III: Other Approaches. Diffraction and Imaging of Reflected Highenergy Electrons from Bulk Crystal Surfaces. Diffraction and Imaging of Inelastically Scattered Electrons: Inelastic Excitations and 'Absorption' Effect in Electron Diffraction. Semiclassical Theory of Thermal Diffuse Scattering. Dynamical Inelastic Electron Scattering I: Bloch Wave Theory. Reciprocity in Electron Diffraction and Imaging. Dynamical Inelastic Electron Scattering II: Green's Function Theory. Dynamical Inelastic Electron Scattering III: Multislice Theory. Dynamical Inelastic Electron Scattering IV: Modified Multislice Theory. Inelastic Scattering in Highresolution Transmission Electron Imaging. Multiple Inelastic Electron Scattering. Inelastic Excitation of Crystals in Thermal Equilibrium with Environment. Appendixes. Index.

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Book SynopsisFrom Antiquity to George Corner.- From Antiquity to George Corner.- The Past Five Decades.- Technological Breakthroughs.- Normal Physiology.- Pathophysiology: The Anovulatory Woman.- Therapeutic Developments.Table of ContentsFrom Antiquity to George Corner.- From Antiquity to George Corner.- The Past Five Decades.- Technological Breakthroughs.- Normal Physiology.- Pathophysiology: The Anovulatory Woman.- Therapeutic Developments.

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Book SynopsisVector Analysis.- Sources and Fields.- Bioelectric Potentials.- Channels.- Action Potentials.- Impulse Propagation.- Electrical Stimulation.- Extracellular Fields.- Cardiac Electrophysiology.- The Neuromuscular Junction.- Skeletal Muscle.- Functional Electrical Stimulation.- Exercises.Trade ReviewPraise for Previous Editions:"This fine text, by two well-known bioengineering professors at Duke University, is an introduction to electrophysiology aimed at engineering students. Most of its chapters cover basic topics in electrophysiology: the electrical properties of the cell membrane, action potentials, cable theory, the neuromuscular junction, extracellular fields, and cardiac electrophysiology. The authors discuss many topics that are central to biophysics and bioengineering [and] the quantitative methods [they] teach will surely be productive in the future." IEEE Engineering in Medicine and Biology "The authors’ goal in producing this book was to provide an introductory text to electrophysiology, based on a quantitative approach. In attempting to achieve this goal, therefore, the authors have opened the book with a useful, and digestible, introduction to various aspects of the mathematics relevant to this field, including vectors, introduction to Laplace, Gauss’s theorem, and Green’s theorem. This book will be useful for students in medical physics and biomedical engineering wishing to enter the field of electrophysiological investigation. It will also be helpful for biologists and physiologists who wish to understand the mathematical treatment of the processes and signals at the center of the interesting interdisciplinary field." Medical and Biomedical Engineering and ComputingTable of ContentsVector Analysis.- Sources and Fields.- Bioelectric Potentials.- Channels.- Action Potentials.- Impulse Propagation.- Electrical Stimulation.- Extracellular Fields.- Cardiac Electrophysiology.- The Neuromuscular Junction.- Skeletal Muscle.- Functional Electrical Stimulation.- Exercises.

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Book SynopsisDefined as, “The science about the development of an embryo from the fertilization of the ovum to the fetus stage,” embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a “development cell.” That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies.Trade ReviewFrom the reviews:“The Introduction by the two editors is clearly telling the aim of such a bible, to cover from the basic aspects of molecular embriology dealing with the stemness cellular capacity … till the new challenging opportunities of tissue engineering. I think the price of the book (€ 170) is worthy enough for what the reader will get. … a book with all the figures in colour, this is a great help while looking at cytology, histology or entangled graphs!” (Carlo Alberto Redi, European Journal of Histochemistry, Vol. 55, 2011)Table of ContentsSection 1: Stem Cell Biology.- Introduction to Stem Cells & Regenerative Medicine.- Embryonic Stem Cells: Discovery, Development, and Current Trends.- Bmi1 in self-renewal and homeostasis of pancreas.- Cancer Stem Cells in Solid Tumors.- Adipose-derived stem cells and skeletal muscle repair.- Regeneration of sensory cells of adult mammalian inner ear.- Stem Cells and Their Use in Skeletal Tissue Repair.- Section 2: Epigenetic and microRNA Regulation in Stem Cells.- Epigenetic identity in cancer stem cells.- Function of MicroRNA-145 in Human Embryonic Stem Cell Pluripotency.- Mesenchymal Stem Cells for Liver Regeneration.- Section 3: Stem Cells for Therapeutic Applications.- The Role of Time-Lapse Microscopy in Stem Cell Research and Therapy.- Therapeutic applications of mesenchymal stem/multipotent stromal cells.- Gastrointestinal stem cells.- Lung epithelial stem cells.- Placental Derived Stem Cells, Potential Clinical Applications.- Bone Marrow Cell Therapy for Acute Myocardial Infarction: A Clinical Trial Review.- Stem cell Transplantation to the Heart.- Adult Neural Progenitor Cells and Cell Replacement Therapy for Huntington’s Disease.- Migration of Transplanted Neural Stem Cells in Experimental Models of Neurodegenerative Diseases.- Prospects for neural stem cell therapy of Alzheimer’s disease.- Section 4: Nuclear Reprogramming and induced Pluripotent Stem Cells.- Nuclear transfer ES cells as a new tool for basic biology.- Pluripotent stem cells in reproductive medicine: Formation of the human germ line in vitro.- Prospects for Induced Pluripotent Stem Cell Therapy for Diabetes.- Keratinocyte induced pluripotent stem cells: from hair to where?.- Generation and Characterization of Induced Pluripotent Stem Cells from Pig.- Induced pluripotent stem cells, on the road toward clinical applications.- Direct reprogramming of human neural stem cells by the single transcription factor Oct 4.- Section 5: Tissue Engineering.- Stem cells and biomaterials: the tissue engineering approach.- Micro-technology for stem cell culture.- Using Lab-on-A-Chip Technologies for Stem cell Biology.- The Development of Small Molecules and Growth Supplements to Control the Differentiation of Stem Cells and the Formation of Neural Tissues.- Long-term propagation of neural stem cells: Focus on 3D culture systems and mitogenic factors.- Section 6: Regenerative Medicine.- Stem Cells and Regenerative Medicine in Urology.- Muscle derived stem cells: a model for stem cell therapy in regenerative medicine.- Regenerative strategies for cardiac disease.- Collecting, Processing, Banking and Use of Cord Blood Stem Cells for Regenerative Medicine.

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Book SynopsisThis book provides readers with the necessary background information and advanced concepts in the field of circuits, at the crossroads between physics, mathematics and system theory. It covers various engineering subfields, such as electrical devices and circuits, and their electronic counterparts. Based on the idea that a modern university course should provide students with conceptual tools to understand the behavior of both linear and nonlinear circuits, to approach current problems posed by new, cutting-edge devices and to address future developments and challenges, the book places equal emphasis on linear and nonlinear, two‐terminal and multi‐terminal, as well as active and passive circuit components. This second volume focuses on dynamical circuits, which are characterized by time evolution and by the concept of state. The content is divided into a set of introductory and a set of advanced‐level topics, mirroring the approach used in the previously published volume. Whenever possible, circuits are compared to physical systems of different natures (e.g. mechanical or biological) that exhibit the same dynamical behavior. The book also features a wealth of examples and numerous solved problems. Further topics, such as a more general framing of linear and nonlinear components, will be discussed in volume 3. Trade Review“This is volume 2 of a basic book on linear and nonlinear circuits for undergraduate electrical engineering students.” (Wai-Kai Chen, zbMATH 1492.94002, 2022)Table of ContentsBasic concepts: two-terminal linear elements with memory and first-order linear circuits.- Advanced concepts: first-order nonlinear circuits.- Basic concepts: linear two-ports with memory and higher-order linear circuits.- Advanced concepts: Higher-order nonlinear circuits – State equations and equilibrium points.- Basic concepts: Analysis of LTI circuits in sinusoidal steady state.- Advanced concepts: Analysis of nonlinear oscillators.

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Book SynopsisThis comprehensive and extensively classroom-tested biophysics textbook is a complete introduction to the physical principles underlying biological processes and their applications to the life sciences and medicine. The foundations of natural processes are placed on a firm footing before showing how their consequences can be explored in a wide range of biosystems. The goal is to develop the readers’ intuition, understanding, and facility for creative analysis that are frequently required to grapple with problems involving complex living organisms. Topics cover all scales, encompassing the application of statics, fluid dynamics, acoustics, electromagnetism, light, radiation physics, thermodynamics, statistical physics, quantum biophysics, and theories of information, ordering, and evolutionary optimization to biological processes and bio-relevant technological implementations. Sound modeling principles are emphasized throughout, placing all the concepts within a rigorous framework. With numerous worked examples and exercises to test and enhance the reader’s understanding, this book can be used as a textbook for physics graduate students and as a supplementary text for a range of premedical, biomedical, and biophysics courses at the undergraduate and graduate levels. It will also be a useful reference for biologists, physicists, medical researchers, and medical device engineers who want to work from first principles.Table of ContentsChapter1: Introduction: The Nature of Biophysics.- Chapter2: The Kinds of Ordinary Materials.- Chapter3: Mechanical Aspects of Biosystems.- Chapter4: Fluid Mechanics Applied to Biosystems.- Chapter5: Acoustics in Biology and Medicine.- Chapter6: Electric and Magnetic Fields in Life.- Chapter7: Light in Biology and Medicine.- Chapter8: Ionizing Radiation and Life.- Chapter9: Bioenergetics.- Chapter10: The Statistical Basis of Bioenergetics.- Chapter11: Biomolecular Structure and Interactions.- Chapter12: Entropy and Information in Biology.- Chapter13: Modeling Biological Systems.- Chapter14: Neural Networks and Brains.- Chapter15: Ordering Theory.- Chapter16: Energy Flow in the Production of Order.- Chapter17: Life in the Universe.- Chapter18: Future Developments.

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Book SynopsisThis textbook describes the basic principles and mechanism of action of biosensor systems, and introduces readers to the various types of biosensors; from affinity biosensors to catalytic, optical and label-free biosensors, the most common systems are explained in detail. Dedicated advanced sections focus on biochips and genome sequencing methods as well as organs-on-a-chip. The textbook helps readers to understand the elementary components of biosensors, and to identify and illustrate each function in the biosensor information flow, from recognition to transduction and transmission. Furthermore, readers will receive guidance in critically analyzing published studies on biosensor research, helping them to develop appropriate concepts and independently propose their own solutions. The textbook is intended for master’s students in bioengineering, biophysics, biotechnology and pharmacology that need a solid grasp of biosensor system technologies and applications, as well as students in related medical technological fields.Table of Contents

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Book SynopsisPart I: The Viral Machine.- Chapter 1: Introduction, The Structural Basis of Virus Function.- Chapter 2: The Basic Architecture of Viruses.- Part II: Determination of the Structure, Dynamics and Physical Properties of Viruses.- Chapter 3: Conventional Electron Microscopy, Cryogenic Electron Microscopy and Cryogenic Electron Tomography of Viruses.- Chapter 4: X-Ray Crystallography of Viruses.- Chapter 5: Nuclear Magnetic Resonance Spectroscopy to study Virus Structure.- Chapter 6: Fluorescence, Circular Dichroism and Mass Spectrometry as Tools to Study Virus Structure.- Chapter 7: Integrative Approaches to Study Virus Structures.- Chapter 8: 3D Cryo-Correlative Methods to Study Virus Structure and Dynamics within Cells.- Chapter 9: Atomic Force Microscopy of Viruses.- Chapter 10: Optical Tweezers to Study Viruses.- Part III: Structural Foundations of Virus Properties and Functions.- Chapter 11: Assembly of Structurally Simple Icosahedral Viruses.- Chapter 12: Architecture and Assembly of Structurally Complex Viruses.- Chapter 13: Nucleic Acid Packaging in Viruses.- Chapter 14: Maturation of Viruses.- Chapter 15: Virus-Receptor Interactions and Receptor-Mediated Virus Entry into Host Cells.- Chapter 16: Entry of Enveloped Viruses into Host Cells: Membrane Fusion.- Chapter 17: Bacteriophage Receptor Recognition and Nucleic Acid Transfer.- Chapter 18: Mechanical Properties of Viruses.- Chapter 19: Theoretical Studies on Assembly, Physical Stability and Dynamics of Viruses.- Part IV: Applied Structural and Physical Virology.- Chapter 20: Antiviral Agents: Structural Basis of Action and Rational Design.- Chapter 21: Design of Novel Vaccines Based on Virus-Like Particles.- Chapter 22: Engineering and Bio/Nanotechnological Applications of Virus Particles.

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Book Synopsis1. Intermittent motion of agents.- 2. Visual search.- 3. Subdiffusive search for a target.- 4. Superdiffusive search for a target.- 5. Evanescent searchers.

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Table of ContentsFrontmatter -- List of authors -- Preface -- Contents -- I. General Problems of Biological Thermodynamics -- Introduction -- Application of the Concepts of Classical Thermodynamics in Biology -- The Second Law, Negentropy, Thermodynamics of Linear Irreversible Processes -- Formalism of Non-Equilibrium Phenomenolagical Thermodynamics -- II. Qualitative Phenomenological Theory of the Development of Organisms -- Introduction -- Experimental Basis for Qualitative Phenomenological Theory of Development -- Theoretical Basis for a Qualitative Phenomenological Theory of Development -- Stochastic Consideration of Constitutive Processes and of the Evolution Criterion -- Strengthened Evolution Criterion in Developmental Biology -- III. Quantitative Phenomenological Theory of Development of Organisms -- Introduction -- Non-Linear Phenomenological Equations -- Differential Equations of Developmental Biology -- Computer Analysis of Non-Linear Growth Equations -- Modern Theories Concerning the Growth Equations -- IV. Heat Production of Living Systems -- Introduction -- Heat Production in Life Processes -- The Change of ?? the Function During the Growth of Microbial Cultures -- Changes of ?? and ?? Functions During Oogenesis of Xenopus Laevis -- Heat Production and Respiration During Development and Growth of two Insects -- Heat Production and Respiration of Axolotle at the Early Stages of Growth -- Relationship Between Heat Production and Body Weight in Growing Organisms -- V. Some Problems of Energetics of Developmental Processes -- Introduction -- Changes in Mitochondria During Development and Growth of Animals -- The Role of Mitochondria in Regulation of Respiration During Oogenesis -- The Energetics of Regeneration Processes -- VI. Dissipative Structures -- Introduction -- Review of the Theory of Dissipative Structures -- Stationary Dissipative Structures -- Dynamic Dissipative Structures -- Dissipative Structures and ?? Function -- The Role of Cyclization of Free Energy in Bio-Physico-Chemical Processes -- VII. Probability State and Orderliness of Biological Systems -- Introduction -- Possible Mechanism of the Origin of Bacteria -- Direction of the Evolutionary Progress of Organisms -- Criterion of Orderliness and some Problems of Taxonomy -- The Questions of Non-Linearity for Using Criterion of Orderliness -- Concluding Remarks -- References -- Index -- Backmatter

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Book SynopsisIn this book, physics in its many aspects (thermodynamics, mechanics, electricity, fluid dynamics) is the guiding light on a fascinating journey through biological systems, providing ideas, examples and stimulating reflections for undergraduate physics, chemistry and life-science students, as well as for anyone interested in the frontiers between physics and biology.Rather than introducing a lot of new information, it encourages young students to use their recently acquired knowledge to start seeing the physics behind the biology. As an undergraduate textbook in introductory biophysics, it includes the necessary background and tools, including exercises and appendices, to form a progressive course. In this case, the chapters can be used in the order proposed, possibly split between two semesters. The book is also an absorbing read for researchers in the life sciences who wish to refresh or go deeper into the physics concepts gleaned in their early years of scientific training. Less physics-oriented readers might want to skip the first chapter, as well as all the "gray boxes" containing the more formal developments, and create their own á-la-carte menu of chapters.Trade Review“Cleri does a masterful job of integrating the history of science with some of the most recent results, in order to give the reader a comprehensive view of where our field has been, and where it now stands. … figures help to bring the material alive, and the detailed ‘grey boxes’ provide important context. … includes a number of challenging and subtle questions at the end of each chapter, guaranteed to make the student (and instructor) think deeply.” (Sonya Bahar, Journal of Biological Physics, 2016)Table of ContentsThermodynamics for Living Systems, Appendix, Problems, References.- Energy, Information and the Origins of Life, Problems, References.- Energy Production and Storage for Life, Problems, References.- Entropic Forces in Cells: Thermodynamics and Hydrodynamics, Problems, References.- Molecular Motors in the Cell, Appendix, Problems, References.- Bioelectricity, Hearts and Brains, Problems, References.- Elasticity and Mechanics of Cells and Tissues, Appendix, Problems, References.- Muscles as Engines, Problems, References.- Physical Variables in Living Systems, Problems, References.- Shapes of Nature, Problems, References.- The Hidden Mathematics of Living Systems, Problems, References.

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Book SynopsisWhat are the relations between the shape of a system of cities and that of fish school? Which events should happen in a cell in order that it participates to one of the finger of our hands? How to interpret the shape of a sand dune? This collective book written for the non-specialist addresses these questions and more generally, the fundamental issue of the emergence of forms and patterns in physical and living systems. It is a single book gathering the different aspects of morphogenesis and approaches developed in different disciplines on shape and pattern formation. Relying on the seminal works of D’Arcy Thompson, Alan Turing and René Thom, it confronts major examples like plant growth and shape, intra-cellular organization, evolution of living forms or motifs generated by crystals. A book essential to understand universal principles at work in the shapes and patterns surrounding us but also to avoid spurious analogies.Table of ContentsIntroduction.- Self-organization at equilibrum. A model system: ferrofluids.- Hierarchical networks of fractures.- Liquid crystals and morphogenesis.- Biological self-organization by way of the dynamics of reactive processes.- Sand dunes.- Morphodynamics of secretory pathways.- From epigenomics to morphogenetic emergence.- Animal morphogenesis.- Phyllotaxy.- Logic of forms.- Forms emerging from collective motion.- Systems of cities and levels of organization.- Levels of organization and morphogenesis: the viewpoint of D'Arcy Thompson.- Morphogenetic models of René Thom.- Morphogenesis, structural stability and epigenetic landscape.- Morphological and mutational analysis: tools for morphogenesis study.- Morphogenesis in computer science.

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Book SynopsisThis book treats essentials from neurophysiology (Hodgkin–Huxley equations, synaptic transmission, prototype networks of neurons) and related mathematical concepts (dimensionality reductions, equilibria, bifurcations, limit cycles and phase plane analysis). This is subsequently applied in a clinical context, focusing on EEG generation, ischaemia, epilepsy and neurostimulation. The book is based on a graduate course taught by clinicians and mathematicians at the Institute of Technical Medicine at the University of Twente. Throughout the text, the author presents examples of neurological disorders in relation to applied mathematics to assist in disclosing various fundamental properties of the clinical reality at hand. Exercises are provided at the end of each chapter; answers are included. Basic knowledge of calculus, linear algebra, differential equations and familiarity with MATLAB or Python is assumed. Also, students should have some understanding of essentials of (clinical) neurophysiology, although most concepts are summarized in the first chapters. The audience includes advanced undergraduate or graduate students in Biomedical Engineering, Technical Medicine and Biology. Applied mathematicians may find pleasure in learning about the neurophysiology and clinic essentials applications. In addition, clinicians with an interest in dynamics of neural networks may find this book useful, too.Trade Review“The book is for sure a valuable contribution to make understandable the concepts of neurophysiology, it’s connection to applied mathematics and the benefits of theoretical achievements for application to clinical problems.” (Claudia simionescu-Badea, zbMATH 1482.92005, 2022)Table of ContentsPart I Physiology of neurons and synapses: Electrophysiology of the Neuron.- Synapses.- Part II Dynamics: Dynamics in one-dimension.- Dynamics in two-dimensional systems.- Part III Networks: Prototype neural networks.- Part IV The electroencephalogram: Basics of the EEG.- Neural mass modeling of the EEG.- Part V Pathology: Hypoxia and neuronal function.- Seizures and Epilepsy.- Part VI Neurostimulation: Neurostimulation.- Epilogue.

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Book SynopsisIntroduction.- What you should have heard somewhere.- Passive motion by diffusion.- On the mechanics of beams, polymers and membranes.- Active motion and enzyme kinetics.- What we didn't talk about.- Bibliography.- Index.

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Book Synopsis1. Electromagnetic Modeling and Optimization of Terahertz Wideband Filters Using an Inverse Convolutional Neural Network with Transfer Function.- 2. All-Dielectric Metasurface Design for High-Performance Vortex Beam Generation in the Terahertz Regime.- 3. Spin-Momentum Locked Field Distribution in Smith-Purcell Radiation.- 4. Generation of Tunable Terajets Using Optical Elements Designed with Quadratic Bézier Curves.- 5. Optimization Design of a Full-Space Terahertz Vortex Beam Generator Based on Deep Learning.

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Book SynopsisOffers a comprehensive survey text for biomedical engineering courses. This book helps biomedical engineers to understand the range of topics such as basic mathematical modeling; anatomy and physiology; electrical engineering, signal processing and instrumentation; biomaterials science and tissue engineering; and medical and engineering ethics.Table of Contents1. Biomedical Engineering: A Historical Perspective 2. Moral and Ethical Issues 3. Anatomy and Physiology 4. Biomechanics 5. Biomaterials 6. Tissue Engineering 7. Compartmental Modeling 8. Biochemical Reactions and Enzyme Kinetics 9. Bioinstrumentation 10. Biomedical Sensors 11. Biosignal Processing 12. Bioelectric Phenomena 13. Physiological Modeling 14. Biomedical Transport Processes 15. Radiation Imaging 16. Medical Imaging 17. Biomedical Optics and Lasers

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