Computational biology / bioinformatics Books
Springer International Publishing AG Patient-Centered Design of Cognitive Assistive Technology for Traumatic Brain Injury Telerehabilitation
Book SynopsisComputer software has been productive in helping individuals with cognitive disabilities. Personalizing the user interface is an important strategy in designing software for these users, because of the barriers created by conventional user interfaces for the cognitively disabled. Cognitive assistive technology (CAT) has typically been used to provide help with everyday activities, outside of cognitive rehabilitation therapy. This book describes a quarter century of computing R&D at the Institute for Cognitive Prosthetics, focusing on the needs of individuals with cognitive disabilities from brain injury. Models and methods from Human Computer Interaction (HCI) have been particularly valuable, initially in illuminating those needs. Subsequently HCI methods have expanded CAT to be powerful rehabilitation therapy tools, restoring some damaged cognitive abilities which have resisted conventional therapy. Patient-Centered Design (PCD) emerged as a design methodology which incorporates both clinical and technical factors. PCD also takes advantage of the patient's ability to redesign and refine the user interface, and to achieve a very good fit between user and system. Cognitive Prosthetics Telerehabilitation is a powerful therapy modality. Essential characteristics are delivering service to patients in their own home, having the patient's priority activities be the focus of therapy, using cognitive prosthetic software which applies Patient Centered Design, and videoconferencing with a workspace shared between therapist and patient. Cognitive Prosthetics Telerehabilitation has a rich set of advantages for the many stakeholders involved with brain injury rehabilitation.Table of ContentsIntroduction.- Some Clinical Features of the Cognitive Disabilities Domain with TBI Examples.- Adapting Computer Software to Address Cognitive Disabilities.- The Primacy of the User Interface.- Patient-Centered Design.- Cognitive Prosthetics Telerehabilitation.- The Active User and the Engaged User.- Patient Case Studies in the Use of Cognitive Assistive Technology: Successes and Failures.- Conclusions, Factors Influencing Outcomes, Anomalies, and Opportunities.- Bibliography.
£26.59
Springer International Publishing AG AI and Big Data in Cardiology: A Practical Guide
Book SynopsisThis book provides a detailed technical overview of the use and applications of artificial intelligence (AI), machine learning and big data in cardiology. Recent technological advancements in these fields mean that there is significant gain to be had in applying these methodologies into day-to-day clinical practice. Chapters feature detailed technical reviews and highlight key current challenges and limitations, along with the available techniques to address them for each topic covered. Sample data sets are also included to provide hands-on tutorials for readers using Python-based Jupyter notebooks, and are based upon real-world examples to ensure the reader can develop their confidence in applying these techniques to solve everyday clinical problems.Artificial Intelligence and Big Data in Cardiology systematically describes and technically reviews the latest applications of AI and big data within cardiology. It is ideal for use by the trainee and practicing cardiologist and informatician seeking an up-to-date resource on the topic with which to aid them in developing a thorough understanding of both basic concepts and recent advances in the field.Table of ContentsIntroduction.- AI and Machine Learning: the Basics.- From Machine Learning to Deep Learning.- Measurement and Quantification.- Diagnosis.- Outcome Prediction.- Quality Control.- AI and Decision Support.- AI in the Real World.- Analysis of Non-imaging Data.- Conclusions.
£999.99
Springer International Publishing AG Computational Intelligence Methods for Bioinformatics and Biostatistics: 17th International Meeting, CIBB 2021, Virtual Event, November 15–17, 2021, Revised Selected Papers
Book SynopsisThis book constitutes revised selected papers from the 17th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2021, which was held virtually during November 15–17, 2021. The 19 papers included in these proceedings were carefully reviewed and selected from 26 submissions, and they focus on bioinformatics, computational biology, health informatics, cheminformatics, biotechnology, biostatistics, and biomedical imaging.Table of ContentsChemical Neural Networks and Synthetic Cell Biotechnology: Preludes to Chemical AI.- Development of Bayesian network for multiple sclerosis risk factor interaction analysis.- Real-Time Automatic Plankton Detection, Tracking and Classification on Raw Hologram.- The first in-silico model of leg movement activity during sleep.- Transfer learning and magnetic resonance imaging techniques for deep neural network-based diagnosis of early cognitive decline and dementia.- Improving bacterial sRNA identification by combining genomic context and sequence-derived features.- High-dimensional multi-trait GWAS by reverse prediction of genotypes using machine learning methods.- A Non-Negative Matrix Tri-Factorization based Method for Predicting Antitumor Drug Sensitivity.- A Rule-based Approach for Generating Synthetic Biological Pathways.- Machine Learning Classifiers based on Dimensionality Reduction Techniques for the Early Diagnosis of Alzheimer’s Disease using Magnetic Resonance Imaging and Positron Emission Tomography Brain Data.- Text Mining Enhancements for Image Recognition of Gene Names and Gene Relations.- Sentence Classification to Detect Tables for Helping Extraction of Regulatory Interactions in Bacteria.- RF-Isolation: a Novel Representation of Structural Connectivity Networks for Multiple Sclerosis Classification.- Summarizing Global SARS–CoV–2 Geographical Spread by Phylogenetic Multitype Branching Models.- Explainable AI Models for COVID-19 Diagnosis using CT-Scan Images and Clinical Data.- The need of standardised metadata to encode causal relationships: Towards safer data-driven machine learning biological solutions.- Deep Recurrent Neural Networks for the Generation of Synthetic Coronavirus Spike Protein Sequences.- Recent Dimensionality Reduction Techniques for High-Dimensional COVID-19 Data.- Soft brain ageing indicators based on light-weight LeNet-like neural networks and localized 2D brain age biomarkers.
£999.99
Springer International Publishing AG Bioinformatics Research and Applications: 18th International Symposium, ISBRA 2022, Haifa, Israel, November 14–17, 2022, Proceedings
Book SynopsisThis book constitutes the proceedings of the 18th International Symposium on Bioinformatics Research and Applications, ISBRA 2022, held in Haifa, Israel, in November 14–17, 2022.The 30 full papers and 4 short papers presented in this book were carefully reviewed and selected from 72 submissions. They were organized in topical sections named: AI and disease; computational proteomics; biomedical imaging; drug screening and drug-drug interaction prediction; Biomedical data; sequencing data analysis.Table of ContentsMLMVFE: A Machine Learning Approach Based on Muli-View Features Extraction for Drug-Disease Associations Prediction.- STgcor: A Distribution-based Correlation MeasurementMethod for Spatial Transcriptome Data.- Automatic ICD Coding based on Multi-granularity Feature Fusion.- Effectively Training MRI Reconstruction Network via Sequentially Using Undersampled k-Space Data with Very Low Frequency Gaps.- Fusing Label Relations for Chinese EMR Named Entity Recognition with Machine Reading Comprehension.- Private Epigenetic PaceMaker Detector using Homomorphic Encryption - Extended Abstract.- NIDN: Medical Code Assignment via Note-Code Interaction Denoising Network.- Research on the prediction method of disease classification based on imaging features.- M-US-EMRs: A Multi-Modal Data Fusion Method of Ultrasonic Images and Electronic Medical Records Used for Screening of Coronary Heart Disease.- Transposition Distance Considering Intergenic Regions for Unbalanced Genomes.- An SMT-based Framework for Reasoning about Discrete Biological Models.- ARGLRR: An Adjusted Random Walk Graph Regularization Sparse Low-rank Representation Method for Single-cell RNA-sequencing Data Clustering.- An Efficient and User-friendly Software for PCR Primer Design for Detection of Highly Variable Bacteria.- A Network-Based Voting Method for Identification and Prioritization of Personalized Cancer Driver Genes.- TDCOSR: A multimodality fusion framework for association analysis between genes and ROIs of Alzheimer’s disease.- Policy-based Hypertension Monitoring using Formal Runtime Verification Monitors.- Deep learning-enhanced MHC-II presentation prediction and peptidome deconvolution.- MMLN: Leveraging Domain Knowledge for Multimodal Diagnosis.- Optimal sequence alignment to ED-strings.- Heterogeneous PPI network representation learning for protein complex identification.- A Clonal Evolution Simulator for Planning Somatic Evolution Studies.- Prediction of Drug-disease Relationship on Heterogeneous Networks Based on Graph Convolution.- t-SNE Highlights Phylogenetic and Temporal Patterns of SARS-CoV-2 Spike and Nucleocapsid Protein Evolution.- MPCDDI: A Secure Multiparty Computation-based Deep Learning Framework for Drug-drug Interaction Predictions.- A Multimodal Data Fusion-based Deep Learning Approach for Drug-Drug Interaction Prediction.- GNN-Dom: an unsupervised method for protein domain partition via protein contact map.- A Locality-Constrained Linear Coding-Based Ensemble Learning Framework for Predicting Potentially Disease-Associated MiRNAs.- Gaussian-enhanced Representation Model for Extracting Protein-Protein Interactions Affected by Mutations.- Distance Profiles of Optimal RNA Foldings.- 2D Photogrammetry Image of Adolescent Idiopathic Scoliosis Screening Using Deep Learning.- EMRShareChain: A Privacy-Preserving EMR Sharing System Model Based on the Consortium Blockchain.- Simulating Spiking Neural Networks based on SW26010pro.- Entropy Based Clustering of Viral Sequences.- A Tensor Robust Model Based on Enhanced Tensor Nuclear Norm and Low-Rank Constraint for Multi-view Cancer Genomics Data.
£56.99
Springer International Publishing AG Advanced Technologies for Protein Complex
Book SynopsisThis book presents advanced expression technologies for the production of protein complexes. Since complexes lie at the heart of modern biology, the expression, purification, and characterization of large amounts of high-quality protein complexes is crucial for the fields of biomedicine, biotechnology, and structural biology. From co-expression in E. coli, yeast, mammalian and insect cells to complex reconstitution from individual subunits, this book offers useful insights and guidance for successful protein expressionists. Across several sections readers will discover existing opportunities for the production of protein complexes in bacterial systems (including membrane proteins and cell-free co-expression), methylotrophic and non-methylotrophic yeasts, protozoa (Leishmania terantolae and Dictyostelium discoideum), baculovirus-infected insect cells, mammalian cells, plants and algae. Complex reconstitution from individually purified subunits or subcomplexes is discussed as a complementary strategy. A last section introduces briefly some of the biophysical and structural characterization techniques for macromolecular complexes using state-of-the-art solution scattering and nuclear magnetic resonance. This work is a guided tour over some of the most powerful and successful protein expression technologies, with a focus on co-expression and high-throughput applications. It is addressed to everyone interested in the production and characterization of macromolecular complexes, from university students who want an accessible description of the major co-expression systems to researchers in biomedicine and the life sciences seeking for an up-to-date survey of available technologies.Table of ContentsPreface. Complex Biologics: Engineering the Tools and the Hosts. M. Cristina Vega, Francisco J. Fernández and Imre Berger Section 1: Introduction 1. Protein complex production from the drug discovery standpoint; Ismail Moarefi <2. Choose a suitable expression host: a survey of available protein production platforms; Francisco J. Fernández and M. Cristina Vega Section 2: Prokaryotic expression hosts 3. ACEMBL Tool-Kits for High-Throughput Multigene Delivery and Expression in Prokaryotic and Eukaryotic Hosts; Yan Nie, Maxime Chaillet, Christian Becke, Matthias Haffke, Martin Pelosse, Daniel Fitzgerald, Ian Collinson, Christiane Schaffitzel and Imre Berger 4. Complex reconstitution and characterization by combining co-expression techniques in Escherichia coli with high-throughput; Renaud Vincentelli and Christoph Romier 5. Membrane protein production in E. coli for applications in drug discovery; Harm Jan (Arjan) Snijder and Jonna Hakulinen6. Cell-free Synthesis of Macromolecular Complexes; Matthieu Botte, Aurélien Deniaud and Christiane Schaffitzel 7. A Bacillus megaterium system for the production of recombinant proteins and protein complexes; Rebekka Biedendieck 8. Protein complex production in alternative prokaryotic hosts; Sara Gómez, Miguel López-Estepa, Francisco J. Fernández and M. Cristina Vega Section 3: Lower Eukaryotic expression hosts 9. Production of Protein Complexes in Non-methylotrophic and Methylotrophic Yeasts; Francisco J. Fernandez, Miguel López-Estepa, Javier Querol-García and M. Cristina Vega 10. Leishmania tarentolae for the Production of Multi-Subunit Complexes; Tomoaki Niimi 11. Alternative Eukaryotic Expression Systems for the Production of Proteins and Protein Complexes; Sara Gómez, Miguel López-Estepa, Francisco J. Fernández, Teresa Suárez and M. Cristina Vega Section 4: Higher Eukaryotic expression hosts 12. Fundamentals of baculovirus expression and applications; Tom A. Kost and Christopher W. Kemp 13. The MultiBac Baculovirus / Insect Cell Expression Vector System for Producing Complex Protein Biologics; Duygu Sari, Kapil Gupta, Deepak Balaji Govinda Raj, Alice Aubert, Petra Dmcova, Frederic Garzoni, Daniel Fitzgerald and Imre Berger 14. Fundamentals of expression in mammalian cells; Michael R. Dyson 15. Assembling multi-subunit complexes using mammalian expression; Bahar Baser and Joop van den Heuvel Section 5: Plant expression 16. Microalgae as solar-powered protein factories; Franziska Hempel and Uwe G. Maier 17. Strategies and methodologies for the co-expression of multiple proteins in plants; Albert Ferrer, Montserrat Arró, David Manzano and Teresa Altabella 18. Transient expression systems in plants—potentialities and constraints; Tomas Canto Section 6: Complex reconstitution 19. Complex reconstitution from individual protein modules; Jérome Basquin, Michael Taschner and Esben Lorentzen 20. Structural reconstruction of protein-protein complexes involved in intracellular signaling; Klára Kirsch, Péter Sok, and Attila Remény Section 7: Biophysical methods to assess protein complexes 21. The use of small-angle scattering for the characterization of multi subunit complexes; Adam Round22. Application of nuclear magnetic resonance and hybrid methods to structure determination of complex systems. Filippo Prischi and Annalisa Pastore
£143.99
Springer International Publishing AG Mathematical Models and Methods for Living Systems: Levico Terme, Italy 2014
Book SynopsisThe aim of these lecture notes is to give an introduction to several mathematical models and methods that can be used to describe the behaviour of living systems. This emerging field of application intrinsically requires the handling of phenomena occurring at different spatial scales and hence the use of multiscale methods.Modelling and simulating the mechanisms that cells use to move, self-organise and develop in tissues is not only fundamental to an understanding of embryonic development, but is also relevant in tissue engineering and in other environmental and industrial processes involving the growth and homeostasis of biological systems. Growth and organization processes are also important in many tissue degeneration and regeneration processes, such as tumour growth, tissue vascularization, heart and muscle functionality, and cardio-vascular diseases.Table of ContentsPreface.- Cell-based, continuum and hybrid models of tissue dynamics.- The Diffusion Limit of Transport Equations in Biology.- Mathematical Models of the Interaction of Cells and Cell Aggregates with the Extracellular Matrix.- Mathematical modeling of morphogenesis in living materials.- Multiscale computational modelling and analysis of cancer invasion.
£58.49
Springer International Publishing AG Pollen Tip Growth: From Biophysical Aspects to Systems Biology
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£116.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Advances in Biomedical Sensing, Measurements, Instrumentation and Systems
Book SynopsisAdvances in technological devices unveil new architectures for instrumentation and improvements in measurement techniques. Sensing technology, related to biomedical aspects, plays a key role in nowadays applications; it promotes different advantages for: healthcare, solving difficulties for elderly persons, clinical analysis, microbiological characterizations, etc.. This book intends to illustrate and to collect recent advances in biomedical measurements and sensing instrumentation, not as an encyclopedia but as clever support for scientists, students and researchers in other to stimulate exchange and discussions for further developments.Table of ContentsDistributed System Architecture Using a Prototype Web E-Nose.- Magnetic Fluids for Bio-medical Application.- Design of the New Prognosis Wearable System-Prototype for Health Monitoring of People at Risk.- Ultra Wide Band in Medical Applications.- A Wearable Force Plate System Designed Using Small Triaxial Force Sensors and Inertial Sensors.- Optical Ranging in Endoscopy: Towards Quantitative Imaging.- Validation of Denoising Algorithms for Medical Imaging.- Dielectrophoretic Actuation and Simultaneous Detection of Individual Bioparticles.- Use of Triaxial Accelerometers for Posture and Movement Analysis of Patients.- Instrumentation and Sensors for Human Breath Analysis.- Decomposition of Photoplethysmographical Arterial Pulse Waves by Independent Component Analysis: Possibilities and Limitations.- Digital Processing of Diagnostic Images.- Expanding the Metrological and Operating Characteristics of Cytofluorimeters.- Biomedical Sensors for Ambient Assisted Living.- Biosignal Processing to Meet the Emerging Needs of Telehealth Monitoring Environments.- Calibration of Automated Non Invasive Blood Pressure Measurement Devices.- Augmented Reality in Minimally Invasive Surgery.- Advances in EEG Signal Processing for Epilepsy Detection.- A Novel Portable Device for Laryngeal Pathologies Analysis and Classification.
£169.37
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Biomechanics of the Human Urinary Bladder
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£116.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Computational Methods to Study the Structure and Dynamics of Biomolecules and Biomolecular Processes: From Bioinformatics to Molecular Quantum Mechanics
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£142.49
World Scientific Publishing Co Pte Ltd Fixing Your Damaged And Incorrect Genes
Book SynopsisFixing Your Damaged and Incorrect Genes is a book about a well-established biological process called DNA REPAIR. The book describes the multiple and varied biochemical strategies by which damaged or incorrect nucleotides are removed from DNA or are corrected. The book includes multiple figures of notable past and present scientists in the field. The book is uniquely focused on an audience of non-biologists and is written in simple language with minimal use of technical terms. It contains an extensive glossary that provides explanations of key words that readers are encouraged to refer to as they read. Fixing Your Damaged and Incorrect Genes is unique, there being no previously published books for non-biologists on the topic of DNA repair.
£23.75
World Scientific Publishing Co Pte Ltd Introduction To Computational Metagenomics
Book SynopsisBreakthroughs in high-throughput genome sequencing and high-performance computing technologies have empowered scientists to decode many genomes including our own. Now they have a bigger ambition: to fully understand the vast diversity of microbial communities within us and around us, and to exploit their potential for the improvement of our health and environment. In this new field called metagenomics, microbial genomes are sequenced directly from the habitats without lab cultivation. Computational metagenomics, however, faces both a data challenge that deals with tens of tera-bases of sequences and an algorithmic one that deals with the complexity of thousands of species and their interactions.This interdisciplinary book is essential reading for those who are interested in beginning their own journey in computational metagenomics. It is a prism to look through various intricate computational metagenomics problems and unravel their three distinctive aspects: metagenomics, data engineering, and algorithms. Graduate students and advanced undergraduates from genomics science or computer science fields will find that the concepts explained in this book can serve as stepping stones for more advanced topics, while metagenomics practitioners and researchers from similar disciplines may use it to broaden their knowledge or identify new research targets.
£72.00
Springer Verlag, Singapore Pharmacokinetics: Basics to Applications
Book SynopsisThis textbook covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject. The book presents mathematical techniques, step- by-step descriptive equations, and applicable statistical analysis methods for the easy understanding of the topic. Further, it covers the preclinical applications and methods of pharmacokinetic aspects. The book also contains mathematical problems and questions related to pharmacokinetics for students. Special emphasis is on recent pharmacokinetic methods and their applications for managing clinical data and biostatistical approaches based on the current literature. This book is primarily meant for researchers and students from academic institutions and to R&D professionals.Table of ContentsChapter 1: Fundamentals of Pharmacokinetics.- Chapter 2: Drug absorption.- Chapter 3: The extent of drug absorption: bioavailability, clearance, bioequivalence, and protein-binding.- Chapter 4: Pharmacokinetic models and drug distribution.- Chapter 5: Drug metabolism .- Chapter 6: Drug elimination and nonlinear kinetics.- Chapter 7: Pharmacokinetic drug-drug interactions.- Chapter 8: Pharmacokinetic applications.- Chapter 9: Pharmacokinetic sample collection and processing.- Chapter 10: Important bio-analytical instrumental techniques in pharmacokinetics.- Chapter 11: Statistics in pharmacokinetics.- Chapter 12: Pharmacokinetic software and tools.- Chapter 13: Pharmacokinetic laboratory-based experiments.- Chapter 14: Pharmacokinetic numerical problems with solutions.- Chapter 15: Questions, and questions & answers for practice.
£54.99
Springer Verlag, Singapore Translational Informatics: Sports and Exercise Medicine
Book SynopsisThe book provides readers the informatics and data-driven models for the discovery of personalized excise prescriptions applied to different cases. Overdiagnosis or over-treatment often happened since the complex interaction among the lifestyle, genetic, and environmental factors. Sports and exercise are reported efficient to prevent or reduce the risk of diseases, but the interactions between sports/exercise and disease are personalized and complex. Translational informatics is a powerful paradigm and it promotes the transfer of big data, knowledge and models to the precision application of sports to prevent diseases. Sports and exercise may have different effects on diverse diseases including cancers, neurodegenerative disease, and cardiovascular diseases, etc. This book covers many modern informatics models such as ontologies, knowledge graphs, blockchain, participatory medicine, semantic artificial intelligence, big data modeling, and so on. It also describes the challenges for the sports and exercise medical data sharing and standardization, the privacy protection of data as well as the integration of data from genomic level to physiological phenotype level. This book will be helpful to the readers who are interesting in sports and exercise medicine, healthcare, big data modeling, artificial intelligence in medicine and healthcare. Table of ContentsChapter 1. Ontologies and Knowledge Graphs for Exercise Medicine.- Chapter 2. Participatory exercise medicine and personalized healthcare.- Chapter 3. Integration of genetic and phenotyping data for sports medicine.- Chapter 4. Microbiota, sports and exercise medicine.- Chapter 5. Human immune system and exercise medicine: current process and future directions.- Chapter 6. Circadian Rhythm and Personalized Exercise.- Chapter 7. Data-driven Exercise Medicine for Cardiovascular Disease.- Chapter 8. Physical Activities and Prevention of Neurodegenerative Diseases.- Chapter 9. Exercise guidelines for cancer patients.- Chapter 10. Diabetes as a metabolic disease and translational exercise medicine informatics.
£999.99
Tarcher/Putnam,US The Cosmic Serpent DNA and the Origins of
Book SynopsisA Copernican revolution for the life sciences.—Medical TribuneUnlock the mysteries of biology, anthropology, and ancient civilizations in this thought-provoking read where science and spirituality intersect. Through Jeremy Narby′s travels and research in the Amazon, he discovered that shamans were able to use hallucinogens to tap into knowledge and insights that rival our discoveries using modern scientific methods, particularly with regards to DNA and molecular biology. Drawing on visionary experiences, indigenous knowledge, and pharmacology, Narby challenges conventional understanding, unraveling the connections between consciousness, serpent symbolism, and the origins of life itself. This enlightening book blends science, anthropology, and mysticism into a captivating narrative that will expand your mind.
£13.98
Charlesbridge Publishing,U.S. Curiosity Guides: The Human Genome
Book SynopsisThe DNA sequence that comprises the human genome--the genetic blueprint found in each of our cells--is undoubtedly the greatest code ever to be broken. Completed at the dawn of a new millennium, the feat electrified both the scientific community and the general public with its tantalizing promise of new and better treatments for countless diseases, including Alzheimer's, cancer, diabetes, and Parkinson's.Yet what is arguably the most important discovery of our time has also opened a Pandora's box of questions about who we are as humans and how the unique information stored in our genomes can and might be used, making it all the more important for everyone to understand the new science of genomics. In the CURIOSITY GUIDE TO THE HUMAN GENOME, Dr. John Quackenbush, a renowned scientist and professor, conducts a fascinating tour of the history and science behind the Human Genome Project and the technologies that are revolutionizing the practice of medicine today. With a clear and engaging narrative style, he demystifies the fundamental principles of genetics and molecular biology, including the astounding ways in which genes function, alone or together with other genes and the environment, to either sustain life or trigger disease.In addition, Dr. Quackenbush goes beyond medicine to examine how DNA-sequencing technology is changing how we think of ourselves as a species by providing new insights about our earliest ancestors and reconfirming our inextricable link to all life on earth.Finally, he explores the legal and ethical questions surrounding such controversial topics as stem cell research, prenatal testing, forensics, and cloning, making this volume of the Curiosity Guides series an indispensable resource for navigating our brave new genomic world.
£13.99
Oxford University Press Living Computers
Book SynopsisThis accessible and entertaining book explores the fundamental connections between life and information and how they emerged inextricably linked, taking the reader on a journey through all the major evolutionary transitions. It records the entire path of how life''s information has evolved, starting from the growing polymers of prelife leading to the first replicators, through RNA and DNA to neural networks and animal brains, continuing through the major transition of human language and writing, into computer clouds, and finally heading towards an unknown future.All currently known life is based on three classes of molecules: proteins - life''s main structural and functional building blocks; DNA - life''s information molecule; and RNA - a molecule that provides the link between these two. Despite the existence of language and the new means of information recording and processing it enabled, at the current stage of life''s evolution, the information stored in the natural repository of oTable of ContentsPreface 1: How to clone oneself? 2: Self-organising molecules 3: Informed self-organisation 4: The simplest life 5: Evolving replicators 6: Life on Earth 7: Evolution as a ratchet of information 8: From DNA to language 9: Epilogue - beyond language
£999.99
Oxford University Press Genomics
Book SynopsisGenomics has transformed the biological sciences. From epidemiology and medicine to evolution and forensics, the ability to determine an organism''s complete genetic makeup has changed the way science is done and the questions that can be asked of it. Its most celebrated achievement was the Human Genome Project, a technologically challenging endeavor that took thousands of scientists around the world 13 years and over 3 billion US dollars to complete. In this Very Short Introduction John Archibald explores the science of genomics and its rapidly expanding toolbox. Sequencing a human genome now takes only a few days and costs as little as $1,000. The genomes of simple bacteria and viruses can be sequenced in a matter of hours on a device that fits in the palm of your hand. The resulting sequences can be used to better understand our biology in health and disease and to ''personalize'' medicine. Archibald shows how the field of genomics is on the cusp of another quantum leap; the implications for science and society are profound.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.Trade ReviewGenomics does an amazingly good job of covering the gist and gestalt of arguably the most wide-ranging and fastest developing of the biological sciences. * CHOICE Reviews *Table of Contents1: What is genomics? 2: How to read the book of life 3: Making sense of genes and genomes 4: The human genome in biology and medicine 5: Evolutionary genomics 6: Genomics and the microbial world 7: The future of genomics Further Reading Index
£9.49
Cambridge University Press Systems Biology of Cancer
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£77.89
Cambridge University Press Methods for Computational Gene Prediction
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£40.72
Cambridge University Press Signals Switches Regulons and Cascades Control of Bacterial Gene Expression 61 Society for General Microbiology Symposia Series Number 61
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£64.59
Cambridge University Press Gene Expression Profiling by Microarrays
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£168.15
Cambridge University Press Methods for Computational Gene Prediction
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£72.90
Cambridge University Press Bayesian Evolutionary Analysis with BEAST
Book SynopsisA comprehensive overview of Bayesian approaches to phylogenetics using Markov chain Monte Carlo (MCMC) methods, offering theoretical insight, pragmatic advice and tools to develop further models. This title is a one-stop reference to applying the latest phylogenetic models in BEAST 2, interpreting the analyses and extending these models further.Trade Review'Want to construct a phylogeny, add in calibrated time points or work out the past history of an epidemic? The open source package BEAST has established itself as the industry standard for all this and more. This definitive book, explaining what is under the hood, how the user can customize extensions and, most critically, a simple 'how to' users guide, is necessary reading for beginners and specialists alike.' Laurence D. Hurst, University of Bath'In concert with the dramatic improvements to DNA sequencing technology, Bayesian inference has revolutionized population genetics, phylogenetics, and divergence time estimation. A similar impact on epidemiology appears imminent via a suite of new Bayesian methods that incorporate host and pathogen DNA sequence data into established mathematical frameworks. This book is an accessible and thorough introduction to these Bayesian procedures. However, the book does far more than explain the theory. It also includes clear guides on how to use the BEAST 2 software for performing Bayesian analyses, and how to visualize the results. Because the software is designed to be extensible, the book instructs users to write their own code to supplement the diverse methods that are already implemented in BEAST 2. This book is timely and is written by two of the leaders of the field. I highly recommend it.' Jeff Thorne, North Carolina State UniversityTable of ContentsPreface; Acknowledgements; Part I. Theory: 1. Introduction; 2. Evolutionary trees; 3. Substitution and site models; 4. The molecular clock; 5. Structured trees and phylogeography; Part II. Practice: 6. Bayesian evolutionary analysis by sampling trees; 7. Setting up and running a phylogenetic analysis; 8. Estimating species trees from multilocus data; 9. Advanced analysis; 10. Posterior analysis and post-processing; 11. Exploring phylogenetic tree space; Part III. Programming: 12. Getting started with BEAST; 13. BEAST XML; 14. Coding and design patterns; 15. Putting it all together; Bibliography; List of authors; List of subjects.
£48.44
Cambridge University Press Biophysics of DNA
Book SynopsisSurveying the last sixty years of research, this book describes the physical properties of DNA in the context of its biological functioning. It is designed to enable both students and researchers of molecular biology, biochemistry and physics to better understand the biophysics of DNA, addressing key questions and facilitating further research. The chapters integrate theoretical and experimental approaches, emphasising throughout the importance of a quantitative knowledge of physical properties in building and analysing models of DNA functioning. For example, the book shows how the relationship between DNA mechanical properties and the sequence specificity of DNA-protein binding can be analyzed quantitatively by using our current knowledge of the physical and structural properties of DNA. Theoretical models and experimental methods in the field are critically considered to enable the reader to engage effectively with the current scientific literature on the physical properties of DNA.Table of ContentsPreface; 1. DNA structures; 2. Conformational transitions; 3. Equilibrium large-scale conformational properties of DNA; 4. DNA dynamics; 5. DNA-protein interaction; 6. Circular DNA; Index.
£84.54
Cambridge University Press GenomeWide Association Studies
Book SynopsisOver the last twenty years, genome-wide association studies (GWAS) have revealed a great deal about the genetic basis of a wide range of complex diseases and they will undoubtedly continue to have a broad impact as we move to an era of personalised medicine. This authoritative text, written by leaders and innovators from both academia and industry, covers the basic science as well as the clinical, biotechnological and pharmaceutical potential of these methods. With special emphasis given to highlighting pharmacogenomics and population genomics studies using next-generation technology approaches, this is the first book devoted to combining association studies with single nucleotide polymorphisms, copy number variants, haplotypes and expressed quantitative trait loci. A reliable guide for newcomers to the field as well as for experienced scientists, this is a unique resource for anyone interested in how the revolutionary power of genomics can be applied to solve problems in complex disease.Trade Review'Genome-Wide Association Studies: From Polymorphism to Personalized Medicine, edited by Krishnarao Appasani, summarizes most elegantly the contributions of GWAS as a major discovery tool linking complex disease phenotypes to genetic variants and associated biological pathways and gene networks that were previously unknown. GWAS has transformed the genetic landscape in complex disease and has informed us more about the genetic underpinnings of common diseases and pharmacogenomics traits than any other tool to date. The present book captures this development elegantly and is a pleasure to read.' Hakon Hakonarson, University of Pennsylvania'From genotype to phenotype: this biological paradigm is now elucidated and extended to the vision of genomic medicine. This highly informative book combines the current knowledge of genome wide association studies with the pathophysiology, epidemiology of human disease, and health condition, especially, implicating in the development of personalized and precision medicine. The combination of technical, scientific, medical, and pharmaco-economic aspects supports the high value of this book for scientists and medical specialists working in the field.' Christine Günther, Chief Executive Officer, apceth GmbH and Co. KG, Munich, Germany'Through my 30 years' experience in genetics of diabetes, I realize that now is an exciting time in the history of medical genetics thanks to successful genome-wide association studies and challenging whole-genome studies using next-generation sequencing technologies. This excellent book, covering a wide-range of topics and their practical examples in this field, is undoubtedly recommended for readers who are interested in or engaged in genomic medicine.' Takuya Awata, International University of Health and Welfare Hospital, Tochigi, Japan'Genome-Wide Association Studies: From Polymorphism to Personalized Medicine has an impressive and diverse list of contributors and will become a highly valuable resource for both experts and researchers entering the field.' Jeanette Schmidt, Vice President of Informatics, Affymetrix, Inc., Santa Clara, USA'This book details how the huge experimental efforts of GWAS can be put into both a biological and medically relevant context, indeed an excellent read for any researcher trying to understand the functional effect of genetic disease association with complex disease.' Tara Caffrey, University of Oxford'This volume provides a great resource for beginners to learn about the recent advances in GWAS and for domain experts to identity the gaps in the area. … The provided software and case studies can guide readers through the procedures and will easily allow a researcher to finish a project on their own. I think this book will be a reliable guide for anyone who wants to learn and understand GWAS. I hope other readers will enjoy the book as much as I did.' Jinliang Yang, The Quarterly Review of BiologyTable of ContentsList of contributors; Foreword Stephen W. Scherer; Foreword Peter M. Visscher; Preface; Part I. Genome-Wide Association Studies: 1. Introduction to genome-wide association Krishnarao Appasani and Raghu K. Appasani; 2. GWAS: a milestone in the road from genotypes to phenotypes Urko Martinez-Marigorta, Juan Antonio Rodriguez and Arcadi Navarro; 3. Introduction to statistical methods in genome-wide association studies Can Yang, Cong Li, Dongjun Chung, Mengjie Chen, Joel Gelernter and Hongyu Zhao; 4. GWAS replicability across time and space Urko Martinez-Marigorta, Juan Antonio Rodriguez and Arcadi Navarro; Part II. Genome-Wide Studies in Disease Biology: 5. Genome-wide association studies of body mass index Tuomas O. Kilpelainen; 6. Identification of myocardial infarction susceptible genes and their functional analyses Kouichi Ozaki and Toshihiro Tanaka; 7. Admixture mapping for disease gene discovery Randall C. Johnson, Cheryl A. Winkler and Meredith Yeager; 8. Genome-wide association analysis in schizophrenia Sven Stringer, Dorien H. Nieman, René S. Kahn and Eske M. Derks; 9. Epigenome-wide association studies in neurodevelopmental disorders Takeo Kubota, Kunio Miyake and Takae Hirasawa; Part III. Single Nucleotide Polymorphisms, Copy Number Variants, Haplotypes and eQTLs: 10. Finding SNPs that affect microRNA regulation in disease-associated genomic regions Laurent F. Thomas and Pal Saetrom; 11. From linkage to complex associations: the role of GABRA2 as a risk factor for alcohol use Sandra Villafuerte, Elisa M. Trucco and Margit Burmeister; 12. Copy number variation in monozygous twins Erwin Brosens, K. G. Snoek, D. Veenma, H. Eussen, D. Tibboel and A. de Klein; 13. Haplotypes of CpG-related SNPs and association with DNA methylation patterns Yiyi Ma, Caren E. Smith, Yu-Chi Lee, Laurence D. Parnell, Chao-Qiang Lai and José M. Ordovás; 14. eQTL mapping Mengjie Chen, Can Yang, Cong Li and Hongyu Zhao; Part IV. Next-Generation Sequencing Technology and Pharmacogenomics: 15. Next-generation sequencing for rare diseases Elena Bosch and Ferran Casals; 16. Next-generation sequencing for complex disorders Ferran Casals and Elena Bosch; 17. Chromosomal breakpoints in breast cancer co-localize with differentially methylated regions Man-Hung Eric Tang, Vinay Varadan, Sitharthan Kamalakaran, Michael Q. Zhang, James Hicks and Nevenka Dimitrova; 18. Signaling network analysis of genomic alterations predict breast cancer drug targets Naif Zaman and Edwin Wang; 19. Pharmacogenetic studies in pediatric acute myeloid leukemia Neha S. Bhise, Lata Chauhan and Jatinder K. Lamba; 20. Pharmacogenomics of antiretroviral drugs Chonlaphat Sukasem, Apichaya Puangpetch and Sadeep Medhasi; Part V. Population Genetics and Personalized Medicine: 21. Population stratification and its implications: lessons from genome-wide studies Sheikh Nizamuddin, Rakesh Tamang and Kumarasamy Thangaraj; 22. How to solve genetic disease on a population scale Barry Merriman; 23. Economics of personalized medicine Katherine Payne and Martin Eden; Index.
£999.99
Cambridge University Press Why Dna
Book SynopsisInformation is central to the evolution of biological complexity, a physical system relying on a continuous supply of energy. Biology provides superb examples of the consequent Darwinian selection of mechanisms for efficient energy utilisation. Genetic information, underpinned by the Watson-Crick base-pairing rules is largely encoded by DNA, a molecule uniquely adapted to its roles in information storage and utilisation.This volume addresses two fundamental questions. Firstly, what properties of the molecule have enabled it to become the predominant genetic material in the biological world today and secondly, to what extent have the informational properties of the molecule contributed to the expansion of biological diversity and the stability of ecosystems. The author argues that bringing these two seemingly unrelated topics together enables Schrödinger''s What is Life?, published before the structure of DNA was known, to be revisited and his ideas examined in the context of our current biological understanding.Trade Review'The essence of the book is in its title. The DNA structures and topology are described so clearly that the reader perceives these intricacies as pure evolutionary elegance, and understands WHY it is only in its balance of stability and agility that life could have started its journey. This book explains how DNA has become the fascinating prism, made of a fabric of complexity and information, into which the living reflects itself. My opinion is passionate because I have been thinking about the same problems for decades, and here I find many of the answers. Especially: what makes DNA so unique? It is a text that I keep reading over again.' Ernesto Di Mauro, IBPM, National Research Council, Rome'In What Is Life? Schrödinger conjectured that, in animate matter, order is derived from order, foreshadowing the discovery of DNA structure. Why DNA? is about this molecule and its dual information content - in linear genetic code and in thermodynamics of three-dimensional DNA structures. It addresses how DNA's intrinsic order led to complex, highly ordered living organisms, in a world that strives towards disorder. Why would DNA supplant RNA in carrying hereditary information during biological evolution? Why did multicellular organisms emerge, since natural selection favours the fittest, such as simple bacteria? What is complexity, and what has it to do with Bayesian logic? How do complexity, information and energy interrelate? This is a succinct discourse on Schrödinger's question, expanding from molecular interactions and genome cooperation to ecological systems and societal evolution. A must-read for biology scholars, and anyone interested in life's origins, biological evolution and the interface of biology and physics.' Georgi Muskhelishvili, Agricultural University of Georgia, TbilisiTable of ContentsAcknowledgements; Preface; 1. The perennial question; 2. The nature of information – information, complexity and entropy; 3. DNA – the molecule; 4. The evolution of biological complexity; 5. Cooperating genomes; 6. DNA, information and complexity; 7. Origins; 8. The complexity of societies; 9. Why DNA – and not RNA?; General reading and bibliography.
£49.39
Cambridge University Press Computational Thinking for Life Scientists
Book SynopsisComputational thinking is increasingly gaining importance in modern biology, due to the unprecedented scale at which data is nowadays produced. Bridging the cultural gap between the biological and computational sciences, this book serves as an accessible introduction to computational concepts for students in the life sciences. It focuses on teaching algorithmic and logical thinking, rather than just the use of existing bioinformatics tools or programming. Topics are presented from a biological point of view, to demonstrate how computational approaches can be used to solve problems in biology such as biological image processing, regulatory networks, and sequence analysis. The book contains a range of pedagogical features to aid understanding, including real-world examples, in-text exercises, end-of-chapter problems, colour-coded Python code, and ''code explained'' boxes. User-friendly throughout, Computational Thinking for Life Scientists promotes the thinking skills and self-efficacy rTrade Review'An excellent and very gentle introduction to bioinformatics for biologists. In contrast to books that focus on algorithms and ignore programming or focus on programming without explaining algorithms, this book is a perfect blend of both algorithms and programming!' Pavel Pevzner, Ronald R. Taylor Chair and Distinguished Professor of Computer Science, University of California at San Diego'The ability to extract quantitative information from data is an essential skill for the modern biologist. In order to maximize the benefit of programming, use of existing computational tools and effective collaboration with computational scientists, biologists must be able to 'think computationally' by gaining a more algorithmic and logical thinking. In their book, Benny Chor and Amir Rubinstein introduce fundamental computational concepts to life sciences students. Each chapter covers a distinct computational idea motivated by a concrete biological challenge. Questions embedded throughout each chapter and code examples provide hands-on practice. Similarly to the way in which chemistry is perceived as being essential to the biology curriculum, computational thinking should also be considered a part of the modern biologist's basic training. This excellent book is essential reading for undergraduate life sciences students.' Assaf Zaritsky, Ben-Gurion University of the Negev, IsraelTable of ContentsIntroduction; Part I. Programming in Python: 1. Crash introduction to python; 2. Efficiency matters – gentle intro to complexity; Part II. Sequences: 3. Sets dictionaries and hashing; 4. Regular expressions and biological patterns; Part III. Networks: 5. Basic notions in graph theory; 6. Shortest paths and breadth first search; 7. Simulation of regulatory networks; Part IV. Images: 8. Digital images representation; 9. Image processing; Part V. Limitations of Computing: 10. Mission impossible; 11. Mission infeasible; Index.
£71.24
Cambridge University Press Why DNA
Book SynopsisInformation is central to the evolution of biological complexity, a physical system relying on a continuous supply of energy. Biology provides superb examples of the consequent Darwinian selection of mechanisms for efficient energy utilisation. Genetic information, underpinned by the Watson-Crick base-pairing rules is largely encoded by DNA, a molecule uniquely adapted to its roles in information storage and utilisation.This volume addresses two fundamental questions. Firstly, what properties of the molecule have enabled it to become the predominant genetic material in the biological world today and secondly, to what extent have the informational properties of the molecule contributed to the expansion of biological diversity and the stability of ecosystems. The author argues that bringing these two seemingly unrelated topics together enables Schrödinger''s What is Life?, published before the structure of DNA was known, to be revisited and his ideas examined in the context of our currenTrade Review'The essence of the book is in its title. The DNA structures and topology are described so clearly that the reader perceives these intricacies as pure evolutionary elegance, and understands WHY it is only in its balance of stability and agility that life could have started its journey. This book explains how DNA has become the fascinating prism, made of a fabric of complexity and information, into which the living reflects itself. My opinion is passionate because I have been thinking about the same problems for decades, and here I find many of the answers. Especially: what makes DNA so unique? It is a text that I keep reading over again.' Ernesto Di Mauro, IBPM, National Research Council, Rome'In What Is Life? Schrödinger conjectured that, in animate matter, order is derived from order, foreshadowing the discovery of DNA structure. Why DNA? is about this molecule and its dual information content - in linear genetic code and in thermodynamics of three-dimensional DNA structures. It addresses how DNA's intrinsic order led to complex, highly ordered living organisms, in a world that strives towards disorder. Why would DNA supplant RNA in carrying hereditary information during biological evolution? Why did multicellular organisms emerge, since natural selection favours the fittest, such as simple bacteria? What is complexity, and what has it to do with Bayesian logic? How do complexity, information and energy interrelate? This is a succinct discourse on Schrödinger's question, expanding from molecular interactions and genome cooperation to ecological systems and societal evolution. A must-read for biology scholars, and anyone interested in life's origins, biological evolution and the interface of biology and physics.' Georgi Muskhelishvili, Agricultural University of Georgia, TbilisiTable of ContentsAcknowledgements; Preface; 1. The perennial question; 2. The nature of information – information, complexity and entropy; 3. DNA – the molecule; 4. The evolution of biological complexity; 5. Cooperating genomes; 6. DNA, information and complexity; 7. Origins; 8. The complexity of societies; 9. Why DNA – and not RNA?; General reading and bibliography.
£20.99
Nova Science Publishers Inc Progress in DNA Damage Research
Book SynopsisThis book presents the latest research on DNA damage, which due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. While this constitutes only 0.000165% of the human genome''s approximately 6 billion bases (3 billion base pairs), unrepaired lesions in critical genes (such as tumour suppresser genes) can impede a cell''s ability to carry out its function and appreciably increase the likelihood of tumour formation. The vast majority of DNA damage affects the primary structure of the double helix; that is, the bases themselves are chemically modified. These modifications can in turn disrupt the molecules'' regular helical structure by introducing non-native chemical bonds or bulky adducts that do not fit in the standard double helix. Unlike proteins and RNA, DNA usually lacks tertiary structure and therefore damage or disturbance does not occur at that level. DNA is, however, supercoiled and wound around "packaging" proteins called histones (in eukaryotes), and both superstructures are vulnerable to the effects of DNA damage.
£149.99
Nova Science Publishers Inc Ribonucleotide Reductase Family: Genetics &
Book SynopsisRibonucleotide reductase (RNR), a universal enzyme present in essentially all living cells and organisms, has a central role in DNA replication and repair by catalysing production of deoxyribonucleotides from the corresponding ribonucleotides. Three major classes of RNRs are known, differing in their cofactor requirements: class I RNRs (with subclasses Ia and Ib) carry a stable tyrosyl radical and are oxygen-dependent, class II RNRs require the vitamin B12 cofactor 5''-deoxyadenosylcobalamin and are oxygen-independent, and class III RNRs carry a stable glycyl radical and are oxygen-sensitive. Despite these differences, all classes have a similar reaction mechanism and the same highly specific catalytic core structure, indicating that they evolved from a common ancestor. Biochemical studies of RNRs from selected model organisms in combination with the vast number of deduced RNR sequences from publicly available complete genomic sequences show that whereas eukaryotes and their viruses with few exceptions contain only class Ia RNRs, all three major RNR classes are found among prokaryotes and bacteriophages and quite often one organism encodes more than one class of RNR. They are compiled in an open access database, called RNRdb for Ribonucleotide Reductase database that is available at http://rnrdb.molbio.su.se. RNRs are produced in a strictly controlled way depending upon growth phase and environmental cues. The authors describe a comprehensive summary of how the expression of RNR genes is regulated in several eubacterial organisms and in yeast. Due to RNR''s importance for the realisation of DNA replication, it has been recognised as a possible target for antiproliferative therapy. The authors present a comprehensive summary of RNR-specific inhibitors that have reached clinical trials and/or are currently used in clinical therapy.
£999.99
Nova Science Publishers Inc Perspectives in Stem Cell Research
Book SynopsisStem cells are cells found in all multi cellular organisms. They are characterised by the ability to renew themselves through mitotic cell division and differentiate into a diverse range of specialised cell types. This book presents and discusses current research in the study of stem cell research, including cancer and prostate stem cells; neural stem cells and taurine; interactions between transplanted neural stem cells and host tissue; retrovirus vector silencing in stem cells and moral and scientific consideration in embryonic stem cell research.
£162.74
Nova Science Publishers Inc Discrete Optimization for TSP-like Genome Mapping
Book SynopsisThis book introduces a discrete optimisation technique in four applications: classic Traveller Salesperson Problem (TSP), Multilocus Genetic Mapping, Multilocus Consensus Genetic Mapping, and Physical Mapping. Each of the four sections contains the problem formulation, description of the algorithm, and experimental results. The foregoing problems are solved on the basis of Guided Evolution Strategy (GES) algorithm. The algorithm was implemented in MultiPoint package (http://multiqtl.com). The developed analytical tools were applied in many genome mapping projects.
£49.59
Nova Science Publishers Inc Chemistry & Mathematics of DNA Polyhedra
Book SynopsisPolyhedra have attracted scientists'' attentions due to their high-symmetric architectures since ancient times, and even served as common modes in natural world. Chemists in the past few centuries have strived to synthesise these polyhedral targets. Despite achievements that have been arrived, there is still a gap between the great varieties of polyhedral shapes observed in nature and the relatively limited molecular polyhedra constructed by small organic molecules. Fortunately, DNA was shown to be an excellent material in molecular construction. The construction of polyhedral structures with DNA improves the development of synthetic chemistry. This book reviews the recent progress made in the theoretical investigation of a new mathematical theory of DNA polyhedra.
£999.99
Nova Science Publishers Inc Telomerase: Composition, Functions & Clinical
Book SynopsisTelomerase is a ribonucleoprotein enzyme that catalyses the cellular synthesis of telomeric DNA during cellular division, resulting in maintenance of telomere length and increased proliferative potential. Several studies suggest that the telomerase may play an important role in the diagnosis and prognosis of cancer because its expression strongly correlates with the potential tumour progression. Ninety percent of human cancers on different organs have shown high telomerasa activity. This book reviews research in the field of telomerase including functions of telomerase independent of its interaction with telomeres on gene expression and chromatin structure; histone deacetylase inhibition as an anticancer telomerase-targeting strategy and others.
£999.99
Nova Science Publishers Inc MicroRNA let-7: Role in Human Diseases & Drug
Book SynopsisMicroRNAs are small non-coding RNAs involved in post-transcriptional regulation of gene expression. Thousands of miRNAs have been identified in different organisms including viruses, insects, plants and animals. MiRNAs has emerged as key regulators of important biological processes. The differential expression of miRNAs in various human diseases has made them potential candidates for developing novel therapies and personalized medicines. This book is focused on microRNA let-7, the second miRNA discovered in the year 2000 and one of the most studied miRNA. This book discusses various aspects of miRNA let-7 starting from its discovery, biogenesis, transcriptional and posttranscriptional regulation to its crucial role in various fundamental cellular processes such as development, stem cell maintenance and differentiation, regulation of signalling pathways in cancer, drug resistance and therapeutic potential in different human diseases.
£86.99
Nova Science Publishers Inc Plasmids: Genetics, Applications & Health
Book Synopsis
£149.99
Nova Science Publishers Inc New Developments in Chromatin Research
Book Synopsis
£149.99
Nova Science Publishers Inc Proline: Biosynthesis, Regulation & Health
Book SynopsisProline might be the most studied amino acid in nature. Many authors have reviewed its many functions in cell homoeostasis. Not only it is essential in primary metabolism, but it is also involved in cell defence response to a variety of stresses. This book presents topical research data in the study of pro-line functions, including role of pro-line in plant subject to salinity, pro-line cycle and its role in secondary metabolite accumulation, role of pro-line in catalysing the asymmetric reaction, studies of polyproline peptides, structural characteristics and transition mechanisms of proline-rich peptides, functions of proline in behaviour of neonatal chicks and tumour suppressor activities of proline oxidase.
£119.99
Nova Science Publishers Inc Latent Fingerprint Examination: Elements, Human
Book SynopsisFingerprints have provided a valuable method of personal identification in forensic science and criminal investigations for over 100 years. Fingerprints left at crime scenes generally are latent prints -- unintentional reproductions of the arrangement of ridges on the skin made by the transfer of materials (such as amino acids, proteins, polypeptides, and salts) to a surface. Palms and the soles of feet also have friction ridge skin that can leave latent prints. The examination of a latent print consists of a series of steps involving a comparison of the latent print to a known (or exemplar) print. Courts have accepted latent print evidence for the past century. However, several high-profile cases in the United States and abroad have highlighted the fact that human errors can occur, and litigation and expressions of concern over the evidentiary reliability of latent print examinations and other forensic identification procedures has increased in the last decade. This book discusses latent print examinations in detail, and provides methods to improving the practice through a systems approach.
£215.99
Yale University Press Meselson Stahl and the Replication of DNA
Book SynopsisIn 1957 two young scientists produced an experiment confirming that DNA replicates as predicted by the double helix structure Watson and Cricks had proposed. This text reconstructs the complex route that led to the experiment and provides an inside view of day-to-day scientific research.Trade Review"Holmes has written a remarkable history of one of molecular biology's most significant experiments. His recreation of a seminal time in the development of the field is masterful and detailed, and it is exciting reading for anyone interested in how experimentation is actually done in a molecular biology laboratory." David Baltimore, president, California Institute of Technology
£69.38
Springer Cytochrome P450 Structure Mechanism and Biochemistry
a huge range and FREE tracked UK delivery on ALL orders.
£170.99
Springer Neural Cell Behavior and Fuzzy Logic
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£123.49
Springer In Silico Immunology
a huge range and FREE tracked UK delivery on ALL orders.
£123.49
Springer Semantic Web Revolutionizing Knowledge Discovery in the Life Sciences
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£123.49
Springer Mathematical Biology
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£89.99
Springer Biomechanics
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£151.99
Springer Understanding Nonlinear Dynamics
a huge range and FREE tracked UK delivery on ALL orders.
£44.99
