Description
Book SynopsisThis volume explores the latest technological advances and covers all facets of systems medicine with respect to precision medicine. The chapters in this book are organized into four parts. Part One highlights the recent achievements in proteomics for biomarkers identification, integration of omics and phenotypic data for precision medicine, and medicine-guided treatment of drug-induced Stevens-Johnson syndrome. Part Two covers systems-based computational approaches for pharmaceutical research and drug development, the principle of optimizing systemic exposure of drugs, and Animal Rule for drug repurposing. Part Three looks at computational tools and methodologies of network biology, quantitative systems toxicology, and modeling and stimulating patient response variabilities. Part Four talks about how systems medicine can address unmet medical and health needs, and identify educational needs. Written in the highly successful Methods in Molecular Biology series format, chapters include
Table of ContentsAcknowledgements…
Preface…
Table of Contents…
Contributing Authors…
Part I Scientific and Medical Advances
1. Mass Spectrometry-Based Proteomics for Biomarker Discovery
Zhijun Cao and Li-Rong Yu
2. Integration of Omics and Phenotypic Data for Precision Medicine
Juan Zhao, QiPing Feng, and Wei-Qi Wei
3. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in the Era of Systems Medicine
Chun-Bing Chen, Chuang-Wei Wang, and Wen-Hung Chung
Part II Acceleration of Pharmaceutical Research and Development
4. Integration of Engineered Delivery with the Pharmacokinetics of Medical Candidates via Physiology-Based Pharmacokinetics
Yuching Yang and Xinyuan Zhang
5. Applications of Quantitative System Pharmacology Modeling to Model Informed Drug Development
Andy Z.X. Zhu and Mark Rogge
6. Combating Viral Diseases in the Era of Systems Medicine
Jane P.F. Bai and Ellen Y. Guo
7. Toxicity Analysis of Pentachlorophenol Data with a Bioinformatics Tool Set
Natalia Polouliakh, Takeshi Hase, Samik Ghosh, and Hiroaki Kitano
Part III Tools and Methodologies
8. Virtual Populations for Quantitative Systems Pharmacology Models
Yougan Cheng, Ronny Straube, Abed E. Alnaif, Lu Huang, Tarek A. Leil, and Brian J. Schmidt
9. Quantitative Systems Toxicology and Drug Development: The DILIsym Experience
Paul B. Watkins
10. Introduction to Genomic Network Reconstruction for Cancer Research
Guillermo de Anda Jáuregui, Hugo Tovar, Segio Alcalá-Corona, Enrique Hernández-Lemus
11. Learning in Medicine: The Importance of Statistical Thinking
Massimiliano Russo and Bruno Scarpa
12. Development and Applications of Interoperable Biomedical Ontologies for Integrative Data and Knowledge Representation and Multiscale Modeling in Systems Medicine
Yongqun He
Part IV Systems Medicine to Address Unmet Medical Needs
13. Systems Biology to Address Unmet Medical Needs in Neurological Disorders
Masha G. Savelieff, Mohamed H. Noureldein, and Eva L. Feldman
14. Informatics in Medical Product Regulation: The Right Drug at the Right Dose for the Right Patient
Eileen Navarro Almario, Anna Kettermann, and Vaishali Popat
15. Personal Dense Dynamic Data Clouds Connect Systems Bio-Medicine to Scientific Wellness
Gilbert S. Omenn, Andrew T. Magis, Nathan D. Price, and Leroy Hood
16. Educational Needs for Quantitative Systems Pharmacology Scientists
James M. Gallo
Subject Index List…
