Biology, life sciences Books
Princeton University Press The Planet Remade How Geoengineering Could Change
Book SynopsisFirst published in Great Britain by Granta Books, 2015.Trade ReviewOne of The Independent's 6 Best Books in Nature 2015 One of Science Friday's Best Science Books of 2016 One of The Guardian's Best Books of 2015 One of The Guardian's Best Science Books of 2015 One of LinkedIn's Best Business Books of 2015 Shortlisted for the Royal Society Insight Investment Science Book Prize 2016 Longlisted for the 2015 Samuel Johnson Prize for Nonfiction "A vital book on geoengineering."--Andrew Revkin, Dot Earth, New York Times "Few science books are more important, timely, and beautifully written... [The Planet Remade] is a book that lays out all the facts, with great clarity and at some length, draws a conclusion, but leaves you to make up your mind."--Cory Doctorow, Boing Boing "[I]f you are going to read one book on climate engineering, it should be The Planet Remade... [The book] is as much an exploration of science and engineering as it is of people and attitudes."--Jane C.S. Long, Nature "Oliver Morton produced 2015's most important and insightful book about the environment inThe Planet Remade... Several people who should know better argued this year that humanity needs to adopt a more 'religious' view of climate change. It does not. What it needs is books by Oliver Morton."--Richard Benson, The Independent "Exhilarating."--New Scientist "Ambitious, enthralling."--Bryan Appleyard, Sunday Times "Morton offers a calm, rational discussion of deliberate technological interventions to cool the planet's climate system... An important account of cutting-edge research that will fascinate serious readers and demand the attention of policymakers."--Kirkus (Starred Review) "Morton accomplishes the difficult task of explaining high-level scientific concepts in pragmatic terms, with enough history, first-person reporting, anecdotes, and humor that The Planet Remade is as enjoyable to read as it is informative."--Foreword Reviews "Through pages of rigorous scientific groundwork wrapped in elegant prose, Morton provides a guided tour of why we need geoengineering... The Planet Remade is a delightful introduction to the seemingly absurd proposals that could be our fragile world's final hope."--Science News "Morton affords us a fascinating look at the perils and promise of geoengineering on a warming planet."--Wan Lixin, Shanghai Daily "[A] thoughtfully written and meticulously reported volume that explores the nascent and controversial field of deliberate technological interventions in the climate--interventions meant to cool the planet."--Pacific Standardz "Morton ... critically evaluates the ethical and scientific pros and cons of using geoengineering to mitigate global climate change. He uses real and theoretical case studies to support his views of past, current, and potential geoengineering options... A valuable resource for environmental science and environmental policy library collections."--ChoiceTable of ContentsIntroduction: Two Questions 1 Climate Risks and Responsibilities 5 The Second Fossil-Fuel Century 8 Altering the Earthsystem 22 Deliberate Planets, Imagined Worlds 26 Part One: Energies 1 The Top of the World 35 Discovering the Stratosphere 38 Fallout 43 The Ozone Layer 47 The Veilmakers 54 2 A Planet Called Weather 57 The Worldfalls 62 The Trenberth Diagram and Climate Science 66 Steam Engines and Spaceship Earth 71 3 Pinatubo 83 Volcanoes and Climate 86 Predictions and Surprises 93 4 Dimming the Noontime Sun 100 Rough Magic 107 Promethean Science 112 5 Coming to Think This Way 124 Martians and Moral Equivalents 129 The Day Before Yesterday 135 The Rise of Carbon Dioxide Politics 139 6 Moving the Goalposts 148 From Plan B to Breathing Space 156 Expanding the Boundaries 165 Part Two: Substances 7 Nitrogen 175 The Making of the Population Bomb 184 Defusing the Population Bomb 189 Far from Fixed 195 How to Spot a Geoengineer 201 8 Carbon Past, Carbon Present 209 The Anthropocene 219 The Greening Planet 229 9 Carbon Present, Carbon Future 243 Ocean Anaemia 251 Cultivating One's Garden 259 10 Sulphur and Soggy Mirrors 268 Global Cooling 274 Cloudships 283 Bright Patchwork Planet 288 What the Thunder Didn't Say 298 Part Three: Possibilities 11 The Ends of the World 305 Control and Catastrophe 312 Doom and Denial 317 The Traditions of Titans 323 A Tale of Two Cliques 332 After Such Knowledge 338 12 The Deliberate Planet 344 The Concert 347 Small Effects, and Bad Ones 359 And Straight on 'til Morning 369 Envoi 375 Acknowledgements 379 References, Notes and Further Reading 383 Bibliography 393 Index 415
£26.18
Princeton University Press Ecological Genetics 5186 Princeton Legacy Library
Book SynopsisTrade Review"The five contributors are all exciting and accomplished researchers in ecological and population genetics... Each contribution expresses a unique and powerful viewpoint on topics of considerable interest."--ScienceTable of ContentsList of ContributorsIntroduction: Current Directions in Ecological Genetics1Gene Flow and Population Structure32Cladistic Analysis of DNA Sequence Data from Subdivided Populations183The Evolution of Phenotypic Plasticity: What Do We Really Know?354Population Structure and Local Adaptation in a Clonal Herbivore585Neutral Models of Phenotypic Evolution866Evolutionary Genetics of Daphnia1097The Interplay of Numerical and Gene-Frequency Dynamics in Host-Pathogen Systems1298Ecological Genetics of Metapopulations: The Silene-Ustilago Plant-Pathogen System1469Ecological Genetics of Life-History Traits: Variation and Its Evolutionary Significance17110Evolution in the Sailfin Molly: The Interplay of Life-History Variation and Sexual Selection205Index233
£54.54
Taylor & Francis Ltd Interindividual Variability in Human Drug
Book SynopsisThe book provides an exhaustive, authoritative and updated review on the interindividual variability in drug metabolism in humans. Four chapters address the general background: genetic factors causing variability, interethnic variability, environmental factors and developing and ageing as sources of variability. Six chapters address variability of drug metabolism in vivo: variability of psychotropic drugs, antiepileptic drugs, the dopamine precursor levodopa, cardiovascular active drugs and anti HIV drugs. Seven chapters address the interindividual variability of the main drug metabolizing enzymes: CYP-450s, acetyltransferases, glucuronosyl transferase, methyl transferases, sulfotransferases and glutathione transferases in human liver and extrahepatic tissues. A separate chapter discusses the prediction of drug interaction.Comprehensive in coverage, and with contributions from the leading international experts, this book is essential reading for researchers from both academiTable of ContentsGenetic Factors That Cause Variability in Human Drug Metabolism. Interethnic Differences in Drug Disposition and Effects. Developing and Ageing as Sources of Variability in Drug Metabolism. Genetic and Environmental Factors Causing Variability in Psychotropic Drug Response. Interindividual Variability in the Metabolism of Cardiovascular Drugs. Interindividual Variability in the Metabolism of Antiepileptic Drugs and its Clinical Implications. Variability in the Metabolism of Levodopa and its Clinical Implications. Interindividual Variability in the Disposition of Anti-HIV Drugs. Predictive Modeling of in vivo Drug Interaction From in vitro Data: From Theory to a Computer-based Workbench and Experimental Validation. Interindividual Variation of P450 Enzymes in vitro and it's Causes. Interindividual Variability of Arylamine N-acetyltransferases. Interindividual Variation of UDP-glucuronosyl Transferases and Drug Glucuronidation. Interindividual Variability of Methyltransferases. Interindividual Variability of Sulpho Transferases. Interindividual Variability of Glutathione Transferase Expression
£237.50
Taylor & Francis Inc NMR for Physical and Biological Scientists
Book SynopsisNuclear Magnetic Resonance spectroscopy is a dynamic way for scientists of all kinds to investigate the physical, chemical, and biological properties of matter. Its many applications make it a versatile tool previously subject to monolithic treatment in reference-style texts. Based on a course taught for over ten years at Brandeis University, this is the first textbook on NMR spectroscopy for a one-semester course or self-instruction. In keeping with the authors' efforts to make it a useful textbook, they have included problems at the end of each chapter.The book not only covers the latest developments in the field, such as GOESY (Gradient Enhanced Overhauser Spectroscopy) and multidimensional NMR, but includes practical examples using real spectra and associated problem sets. Assuming the reader has a background of chemistry, physics and calculus, this textbook will be ideal for graduate students in chemistry and biochemistry, as well as biology, physics, and biophysiTable of Contents1. What Is Spectroscopy? 2. Elementary Aspects of Nuclear Magnetic Resonance (NMR) 3. Elementary Aspects of NMR II: Fourier Transform NMR 4. Nuclear Spin Relaxation and the Nuclear Overhauser Effect 5. Classical and Quantum Descriptions of NMR Experiments in Liquids 6. Density Operator and Product Operator Descriptions of NMR Experiments in Liquids 7. Homonuclear Two-Dimensional NMR Experiments and Coherence Selection 8. Heteronuclear Correlations in NMR 9. Building Blocks for Multidimensional NMR and Special Considerations for Biological Applications of NMR 10. NMR under Anisotropic Conditions: NMR in the Solid State and Ordered Fluids 11. Relaxation Revisited: Dynamic Processes and Paramagnetism 12. Diffusion, Imaging, and Flow
£166.25
Taylor & Francis Inc Practical Military Ordnance Identification Second
Book SynopsisThe threat variables associated with military ordnance are enormous, requiring the application of a structured process to identify unknown munitions. The focus of Practical Military Ordnance Identification, Second Edition is the application of a practical deductive process to identify unknown ordnance items that are commonly recovered outside military control.The author supplies a seven-step procedure to identify unknown munitions by their category, group, and type. Detailed logic trees help users narrow down the possibilities in order to accurately identify ordnance. The book covers the safety precautions associated with each category and group of ordnance. It describes many ordnance construction characteristics and explains the fundamentals of military ordnance fuzing. Appendices define terms and supply abbreviations and acronyms used to describe military ordnances.Coverage new to this edition include: a list of conventional markings; additional safety precautTrade ReviewWhether used as a text book outline for a formal course, or as a stand-alone methodology for identifying unknown ordnance, this book will not disappoint. I highly recommend it as a valuable tool for public safety agencies or small departments who may not have access to dedicated explosive ordnance disposal resources. Allan Vosburgh, CEO, Golden West Humanitarian FoundationTable of Contents1. Overview of Energetics Associated with Ordnance 2. Fundamentals of a Practical Process 3. Fuze Functioning 4. Projectiles 5. Grenades (Hand, Rifle & Projected) Chapter 6: Bombs & Aerial Dispensers 7. Rockets8. Guided Missiles 9.: Submunitions 10. Landmines 11. Chemical Ordnance 12. Underwater Ordnance Chapter 13: Black Powder Filled Ordnance Chapter 14: Closing List of Appendices Appendix A. Logic Trees Appendix B. Abbreviations Appendix C. Definitions of Ordnance Related Terms Appendix D. Explosives Appendix E. English – Metric Conversion Chart Appendix F. References
£150.00
Taylor & Francis Inc Practical Military Ordnance Identification Second
Book SynopsisThe threat variables associated with military ordnance are enormous, requiring the application of a structured process to identify unknown munitions. The focus of Practical Military Ordnance Identification, Second Edition is the application of a practical deductive process to identify unknown ordnance items that are commonly recovered outside military control.The author supplies a seven-step procedure to identify unknown munitions by their category, group, and type. Detailed logic trees help users narrow down the possibilities in order to accurately identify ordnance. The book covers the safety precautions associated with each category and group of ordnance. It describes many ordnance construction characteristics and explains the fundamentals of military ordnance fuzing. Appendices define terms and supply abbreviations and acronyms used to describe military ordnances.Coverage new to this edition include: a list of conventional markings; additional safety precautTrade ReviewWhether used as a text book outline for a formal course, or as a stand-alone methodology for identifying unknown ordnance, this book will not disappoint. I highly recommend it as a valuable tool for public safety agencies or small departments who may not have access to dedicated explosive ordnance disposal resources. Allan Vosburgh, CEO, Golden West Humanitarian FoundationTable of Contents1. Overview of Energetics Associated with Ordnance 2. Fundamentals of a Practical Process 3. Fuze Functioning 4. Projectiles 5. Grenades (Hand, Rifle & Projected) Chapter 6: Bombs & Aerial Dispensers 7. Rockets8. Guided Missiles 9.: Submunitions 10. Landmines 11. Chemical Ordnance 12. Underwater Ordnance Chapter 13: Black Powder Filled Ordnance Chapter 14: Closing List of Appendices Appendix A. Logic Trees Appendix B. Abbreviations Appendix C. Definitions of Ordnance Related Terms Appendix D. Explosives Appendix E. English – Metric Conversion Chart Appendix F. References
£64.59
Taylor & Francis Inc Red Blood Cell Substitutes
Book SynopsisDiscusses regulatory and economic issues pertaining to the formulation of effective and safe red blood cell substitutes. This text examines regulatory and socioeconomic aspects of blood substitute products, and global tranfusion practices from the perspective of blood banks and the US Food and Drug Administrations.Table of ContentsUtilization - economic and regulatory issues: the impact of blood substitutes on blood banking world wide; potential use of red blood cells substitutes within the military; blood substitutes - unique regulatory aspects. Fundamental principles of oxygen transport : oxygen transport, oxygen carriers, and the transfusion trigger; microcirculatory consequences of blood substitutes with haemoglobin solutions; efficacy of perfluorocarbon-based emulsion as a temporary oxygen carrier; pathophysiology of oxygen utilization in haemorrhagic shock - studies with human recombinant haemoglobin. Interactions with organ systems: immunological alterations following haemorrhagic shock - considerations for resuscitation with blood substitutes; the effect of haemoglobin-based substitutes on kidney function; interactions of haemoglobin with the central nervous system. Interactions with molecular species: interactions between haemoglobin and bacterial endotoxin In Vitro and In Vivo. Alternative strategies and indications: encapsulation of haemoglobin in liposomes; the use of blood substitutes in tumour therapy; human haemoglobin derived from transgenic swine - a starting material for 'blood substitute' formulations. Clinical development: OptroTM (recombinant human haemoglobin) - a therapeutic for the delivery of oxygen and the restoration of blood volume in the treatment of acute blood loss in trauma and surgery; production, characterization, and clinical evaluation of hemolinkTM on o-raffinose cross-linked haemoglobin-based blood substitute; hemassistTM - development and clinical profile; the clinical development of human polymerized haemoglobin; oxypureTM - development of polymerized bovine haemoglobin; febluobronTM - development of an oxygen carrying perfluobronTM - development of an oxygen carrying perfluorocarbon. Future directions: future perspective of red cells substitutes.
£285.00
Taylor & Francis Inc Compact Handbook of Computational Biology
Book SynopsisThe assimilation of computational methods into the life sciences has played an important role in advancing biological research. From sequencing genomes to discovering motifs in large collections of functionally equivalent sequences of nucleic acids and proteins, the value of powerful computational tools has become abundantly clear. The Compact Handbook of Computational Biology describes the foundational concepts, techniques, and challenges of biomolecular sequence analysis, biopolymer structure analysis and prediction, genomics, and molecular evolution.Comprising contributions from renowned scientists, many of whom pioneered current methodologies, the Compact Handbook of Computational Biology offers interdisciplinary and authoritative coverage of methods for analysis of nucleic acid and protein sequences and structures, definition and detection of motifs in nucleic acid and protein sequences, protein structure prediction, and discrete modeling of biopolymers. Specific computational topics include computer-assisted research on protein folding, computer-assisted studies of DNA-protein interactions, computer-assisted genomics, proteomics, and comparative genomics, and computer-assisted studies of genome evolution at the molecular (DNA) level.Offering a survey of specific algorithms that have proven successful in molecular biology, genomics, structural biology, and bioinformatics, this invaluable handbook is an authoritative source covering terminology, software, and applications of computational biology.Table of ContentsForeword. Contributors. Introduction: Computational Biology in 14 Brief Paragraphs. Biomolecular Sequence Analysis. Introduction to Pragmatic Analysis of Nucleic Acid Sequences. Motifs in Sequences: Localization and Extraction. Protein Sequence Analysis and Prediction of Secondary Structural Features. Biopolymer Structure Calculation and Prediction. Discrete Models of Biopolymers. Protein Structure Folding and Prediction. DNA-Protein Interactions: Target Prediction. Genome Analysis and Evolution. Methods of Computational Genomics: An Overview. Computational Aspects of Comparative Genomics. Computational Methods for Studying the Evolution of the Mitochondrial Genome. Appendix 1: Computational Biology: Annotated Glossary of Terms. Appendix 2: A Dictionary of Programs for Sequence Analysis. Index.
£999.99
Taylor & Francis Inc Nutrients and Cell Signaling 10 Oxidative Stress
Book SynopsisCell signaling is at the core of most biological processes from the simplest to the most complex. In addition to unicellular organisms possessing the essential ability to receive inputs with regard to nutrient availability and noxious stimuli, the cells in multicellular organisms require signaling from adjacent, as well as distant cells to maintain normal internal function, including growth, differentiation, and homeostasis. Conversely, the etiology of many disease processes, such as those involving immune system dysfunction and tumor development, have been traced to aberrant cell signaling. Nutrients and Cell Signaling, in presenting contributions from a wide array of experts in the field, fully delineates the role of nutrients in cell signaling. The text emphasizes broad concepts and covers all major groups of nutrients. Contributors discuss the role of carbohydrates, amino acids, lipids, vitamins, minerals, and trace elements in essential processes such as cell proliferatioTable of ContentsNuclear receptors, transcription factors, and signaling cascades. Amino acids, lipids, and glycation. Insulin release, signaling, and insulin resistance. Calcium-dependent signaling. Feeding and nutrient homeostasis.
£228.00
Taylor & Francis Inc Oxidative Stress Inflammation and Health
Book SynopsisFocusing on the redox regulation of cell signaling responsible for oxidative stress and inflammatory tissue damage, this reference presents a comprehensive overview of research on the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes induced by endogenous and xenobiotic factors.Table of ContentsOxidants and Antioxidants: Mechanism of Action and Regulation of Gene Expression by Bio?avonoids. Transcriptional Regulation of Cellular Antioxidant Defense Mechanisms. Redox Regulation of In?ammatory Tissue Damage by Thioredoxin. Regulation of NF-kB-Driven In?ammatory Genes by Phytoestrogens. Nuclear Factor-kB as Target for Chemoprevention. Heme Oxygenase-1: An Emerging Major Cellular Defense Against Cigarette Smoke-Induced Oxidative Stress and Cytotoxicity. Biphasic Induction of HO-1 in Macrophages Treated with Lipopolysaccharide: Role of HO-1 Induction in Cell Survival from Oxidative Stress. The Role of Ga12 Proteins in the PKC and JNK-Dependent Induction of NOS by Thrombin. Actions of 8-Hydroxyguanine in DNA. Role of Oxidative Stress in Hypercholesterolemia-Induced In?ammation. Oxidative Stress in Rheumatoid Arthritis. Roles of Carbon Monoxide and Nitric Oxide in Liver Damage. Role of Oxidative Stress and In?ammatory Response in Smokers and Chronic Obstructive Pulmonary Disease. Association of Chronic In?ammation with Carcinogenesis: Implications of Anti-In?ammatory Strategies for Cancer Prevention. Molecular In?ammation as an Underlying Mechanism of Aging: The Anti-in?ammatory Action of Calorie Restriction. Oxidative Stress in Mitochondria: The Involvement in Neurodegenerative Diseases. Implications of In?ammatory Stress in Alzheimer's Disease. Biomarkers for Evaluating Antioxidant Effects. Antioxidant and Neuroprotective Potentials. Resveratrol-A Unique Polyphenolic Antioxidant Present in Grape Skins and Red Wine-Is a Preventive Medicine Against a Variety of Degenerative Diseases. Molecular Mechanisms of Prevention Against Allergic Rhinitis by Aller-7, A Novel Polyherbal Formulation. Antioxidant Character of Selenium and Its Survival Signals by Activation of PI3-K/Akt Pathways. Neuroprotection by Rasagiline and Related Propargylamines Is Mediated by Suppression of Mitochondrial Death Signal and Induction of Antiapoptotic Genes. Index.
£237.50
Taylor & Francis Inc Thiamine
Book SynopsisThiamine: Catalytic Mechanisms in Normal and Disease States brings together the most recent developments in thiamine diphosphate (TDP)-requiring enzyme research and details the mechanisms of catalysis and structure-function relationships, as well as pathophysiological aspects of a spectrum of diseases associated with TDP-requiring enzymes. Providing new insights into neurogenerative diseases, this volume associates defects in the function of TDP-dependent enzymes with numerous metabolic disorders and disease states and offers novel aspects of thiamine enzymes in chiral synthesis as well as new perspectives on the cellular role of thiamine triphosphate and thiamine triphosphates.Table of ContentsChemical Intermediates in Catalysis by Thiamine Diphosphate, Perry A. Frey; Mechanistic and Structural Studies on Thiamine Biosynthetic Enzymes, Tadhg P. Begley and Steven E. Ealick; Studies on the Structure and Function of Thiamine Pyrophosphokinase, Jing-Yuan Liu, David E. Timm, Robert A. Harris and Thomas D. Hurley; New Perspectives on the Cellular Role of Thiamine Triphosphate and Thiamine Triphosphatase, Lucien Bettendorff and Pierre Wins; How Thiamine Works in Enzymes - Time-Resolved NMR Snapshots of ThDP-Dependent Enzymes in Action, Kai Tittmann, Ralph Golbik, Kathrin Uhlemann, Ludmila Khailova, Mulchand Patel, Frank Jordan, David Chipman, Ronald G. Duggleby and Gerhard H bner; Thiamine-Dependent Enzymes as Catalysts of C-C-Bonding Reactions - The Role of Orphan Enzymes, Michael Muller and Georg A. Sprenger; Ligand-Induced Conformational Changes in Thiamine Diphosphate-Dependent Enzymes - Comparison Between Crystal and Solution Structures, Stephan Konig, Michael Spinka, Erik Fiedler, Georg Wille, Johanna Brauer, Michel H.J. Koch and Dmitri I. Svergun; Enantioselective Synthesis of Hydroxy Ketones via Benzaldehyde Lyase- and Benzoylformate Decarboxylase-Catalyzed C-C Bond Formation, Bettina Lingen, Andreas Liese and Michael Muller; Benzoylformate Decarboxylase - Lessons in Enzymology, Michael J. McLeish, George L. Kenyon, Elena S. Polovnikova, Asim K. Bera, Natalie L. Anderson and Miriam S. Hasson; New Concept on the Nature of the Induced Absorption Band of Holotransketolase, Marina V. Kovina, Irina A. Bykova, Olga N. Solovjeva, Ludmilla E. Meshalkina and German A. Kochetov; Structure of the a-Carbanion/Enamine Reaction Intermediate in the Active Site of Transketolase, Determined by Kinetic Crystallography, Tatyana Sandalova, Erik Fiedler, Stina Thorell, Ralph Golbik, Stephan Konig and Gunter Schneider; Yeast Pyruvate Decarboxylase - New Features of the Structure and Mechanisms, Frank Jordan, Min Liu, Eduard Sergienko, Zhen Zhang, Andrew Brunskill, Palaniappa
£256.50
Taylor & Francis Inc Metal Ions in Biological Systems
Book SynopsisThe Metal Ions in Biological Systems series is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine. Written by 36 internationally recognized experts and enriched with nearly 200 illustrations, Volume 40 highlights fast moving research on lanthanides and their interrelations with biosystems and emphasizes their recent impact in biochemical and biological studies, and in medicine. Table of ContentsDistribution of the Lanthanides in the Earth's Crust; Mobilization of Lanthanides through the Terrestrial Biosphere; Complexes of Lanthanide Ions with Amino Acids, Phosphates, and Other Ligands of Biological Interest in Solution; Biologically Relevant Structural Coordination Chemistry of Simple Lanthanide Ion Complexes; Lanthanide Ions as Probes in Studies for Metal Ion-Dependent Enzymes; Lanthanide Chelates as Fluorescence Labels for Diagnostics and Biotechnology; Responsive Luminescent Lanthanide Complexes; Lanthanide Ions as Probes of Electron Transfer in Proteins; Lanthanide Ions as Luminescent Probes of Proteins and Nucleic Acids; Lanthanide-Promoted Peptide Bond Hydrolysis; Lanthanide-Catalyzed Hydrolysis of Phosphate Esters and Nucleic Acids; Sequence-Selective Scission of DNA and RNA by Lanthanides and Their Complexes; Lanthanide Ions as Probes for Metal Ions in the Structure and Catalytic Mechanism of Ribozymes; Lanthanides as Shift and Relaxation Agents in Elucidating the Structure of Proteins and Nucleic Acids; Lanthanide Ions as Magnetic Resonance Imaging Agents. Nuclear and Electronic Relaxation Properties. Applications; Interactions of Lanthanides and Their Complexes with Proteins. Conclusions Regarding Magnetic Resonance Imaging.
£356.25
Taylor & Francis Inc Metal Ions in Biological Systems
Book SynopsisOffering an authoritative and timely account by twenty-nine internationally recognized experts, Metal Ions in Biological Systems: Metal Complexes in Tumor Diagnosis and as Anticancer Agents is devoted solely to the vital research area concerning metal complexes in cancer diagnosis and therapy. In fourteen stimulating chapters, the book focuses on diagnostic tools such as magnetic resonance imaging (MRI), luminescent probes, and radiopharmaceuticals, including radiometallo-labeled peptides and assesses the role of metal ions, especially iron, in the action of antibiotics employed in anticancer chemotherapy.Trade Review"This is one of two recent volumes in a most successful series publishes since 1973 and which enjoys world renown and respect as both reference and as training material; the current volume is no exception. … [T]his is a gem of a book for both newcomers and established researchers in the field; long may they continue!" - Applied Organometallic Chemistry, 2005Promo CopyTable of ContentsMagnetic Resonance Contrast Agents for Medical and Molecular Imaging. Luminescent Lanthanide Probes as Diagnostic and Therapeutic Tools. Radio-Lanthanides in Nuclear Medicine. RadioMetallo-Labeled Peptides in Tumor Diagnosis and Therapy. Cisplatin and Related Anticancer Drugs. Recent Advances and Insights. The Effect of Cytoprotective Agents in Platinum Anticancer Therapy. Antitumor Activity of Trans-Platinum Species. Polynuclear Platinum Drugs. Platinum(IV) Anticancer Complexes. Ruthenium Anticancer Drugs. Antitumor Titanium Compounds and Related Metallocenes. Gold Complexes as Antitumor Agents. Gallium and Other Main Group Metal Compounds as Antitumor Agents. Metal Ion Dependent Antibiotics in Chemotherapy.
£285.00
Taylor & Francis Inc Genetics of Bacterial Polysaccharides
Book SynopsisUses studies of enteric bacteria to set the stage for the analysis of the genetics of polysaccharides and other bacterial pathogens. This volume presents the genetic analysis of polysaccharides from a number of bacteria pathogenic to humans and one symbiotic with plants in hopes that similarities in the experimental approaches.Table of ContentsIntroduction Chapter 1 Genetics of Pseudomonas aeruginosa polysaccharides Chapter 2 Molecular genetics of Yersinia lipopolysaccharide Chapter 3 Rhizobial cell surface carbohydrates: Their structures, biosynthesis, and functions Chapter 4 The genetics of capsule and lipooligosaccharide biosynthesis in Haemophilus influenzae Chapter 5 The genetics of LPS synthesis by the gonococcus Chapter 6 Genetics of Vibrio cholerae O1 and O139 surface polysaccharides Chapter 7 Common themes in the genetics of streptococcal capsular polysaccharides Chapter 8 Capsular polysaccharides of Staphylococcus aureus Chapter 9 Arabinogalactan in mycobacteria: Structure, biosynthesis, and genetics
£237.50
Taylor & Francis Inc Micronutrients and HIV Infection
Book SynopsisAnalogous to other infections, evidence suggests that improved micronutrient intake may reduce HIV transmission and progression, as well as morbidity from common and opportunistic infections. This is important information, considering many in the world's HIV-infected population do not yet have access to anti-retroviral drugs. Micronutrients and HIV Infection presents current knowledge on the role of micronutrients in HIV and other infections - knowledge that can be used to improve case management and public health interventions.The book provides a comprehensive overview of micronutrients and HIV infection through a review of recently published human studies and intervention trials and other important epidemiology based literature. It begins by introducing the malnutrition-infection complex, Nutritionally Acquired Immune Deficiency Syndrome, and the role of oxidative stress in infection. Then the book covers the history, biochemistry, biological functions, and food sources ofTrade Review"Nineteen authors from 6 countries, 11 of them with medical degrees, contributed the 11 chapters (citing 1009 references) of this very readable and well-edited book. …For a multi-authored volume, Micronutrients and HIV Infection has remarkably and refreshingly little redundancy. Moreover, some authors discuss the adverse consequences of excessive nutrient exposure on the course of HIV and opportunistic infections and the nutrient-nutrient interactions that can arise from nutrient interventions. The book also offers some priceless teaching illustrations." - Noel W. Solomons and Monica Orozco in American Journal of Clinical Nutrition, Vol. 25Table of ContentsIntroduction. Nutritionally Acquired Immune Deficiency. Oxidative Stress and Infections. Vitamin A and Carotenoids. B-Complex Vitamins. Vitamin C. Vitamin E. Iron. Selenium. Other Micronutrients. Micronutrients in the Case-Management of HIV: Developed Countries. Micronutrients in Public Health and Interventions: Developing Countries.
£199.50
Taylor & Francis Inc Atlas of Cell Organelles Fluorescence
Book SynopsisContaining over 150 original photomicrographs accompanied by protocol information, Atlas of Cell Organelles Fluorescence delineates organelles' structures, interaction, and organization into complexes. It provides a collection that shows living cells under physiopathological conditions and in the context of treatment with carcinogens, xenobiotics, and chemotherapeutic drugs as well as photosensitizers. A guide for therapeutic, diagnostic, or prognostic interpretation of images, and for further research, the atlas helps you identify critical points of attack and suggests possible strategies for investigation. Each section provides a brief introduction and the technical details of the staining methods used. The text identifies the organelles and gives explanations of unusual appearances and the cytochemical reactions when necessary. Additional text is provided where appropriate for extension and implementation of methods being utilized to generate similar results. In all cases Table of ContentsVital Fluorescence Probes of Cell Organelles. Metabolic Probes. Cytotoxic Drugs. Genetic Diseases. Cell Differentiation and Cell Pathology. Cell-to-Cell Communication. The Study of Microecosystems. Biotechnology. Instrumentation. Novel Methods and Instrumental Designs. Conclusion. Index.
£228.00
Taylor & Francis Inc Molecular Morphology in Human Tissues
Book SynopsisMolecular Morphology in Human Tissues: Techniques and Applications presents the most advanced molecular morphological techniques to date. This integrated approach to molecular morphology provides powerful analytical and diagnostic tools at the genome level, making the diagnosis and management of cancer, viral infections, and other diseases more precise and reliable. The pioneers of these techniques contribute step-by-step protocols with tips, guidelines, and other suggestions from their own notebooks, enabling experienced scientists as well as beginners to apply the most progressive detection methods available and to obtain optimal results.Table of ContentsMolecular Morphology in Human Tissues: Techniques and Applications presents the most advanced molecular morphological techniques to date. This integrated approach to molecular morphology provides powerful analytical and diagnostic tools at the genome level, making the diagnosis and management of cancer, viral infections, and other diseases more precise and reliable. The pioneers of these techniques contribute step-by-step protocols with tips, guidelines, and other suggestions from their own notebooks, enabling experienced scientists as well as beginners to apply the most progressive detection methods available and to obtain optimal results.
£228.00
Taylor & Francis Inc Carcinogenic and Anticarcinogenic Food Components
Book SynopsisDietary cancer prophylaxis is based on the detailed knowledge of carcinogenic and anticarcinogenic properties of food constituents. Although much data has been collected on these elements, an understanding of the causal mechanisms that link diet and cancer is still evolving. Carcinogenic and Anticarcinogenic Food Components explains the broad spectrum of information available on these compounds and examines what is behind their complexities. Internationally renowned biochemists, toxicologists, epidemiologists, and food scientists present the most recent studies that relate cancer risk to particular dietary components and discuss the latest clinical trials that evaluate the benefits of nutritional interventions. They discuss dietary sources containing carcinogenic compounds, their abundance in foods, and their possible cancer risks. Conversely, they explain the cancer- preventive potential of food components and the basic mechanisms and targets of chemoprevention. ChaTrade Review"... The three editors and their 33 contributors of the 17 chapters have covered this subject very well. … covers wide-ranging subjects, with interesting information on the causes and the likelihood of prevention of cancer from the consumption of selective foods. …gives a good understanding of this interesting and controversial issue, which could be of interest to research scientists in trying to understand the importance of diet on human health in general. It also gives an insight into this issue to professionals working within the food industry and to researchers in food science and nutrition."—Ara Kanekanian, in International Journal of Dairy Technology, Vol 61, No 3 August 2008Table of ContentsFood and Cancer: Development of an Association. Molecular Mechanisms of Carcinogenesis. Metabolism of Chemical Carcinogens. Genotoxic Food Components. Impact of Food Preservation, Processing, and Cooking on Cancer Risk. Environmental Contamination of Food. Dietary Anti- and Prooxidants: Their Impact on Oxidative DNA Damage and Cancer Risk. Dietary Polyunsaturated Fatty Acids, Eicosanoids, and Intestinal Tumorigenesis. Chemoprevention of Cancer: Basic Mechanisms and Molecular Targets. Chemopreventive Phenolic Compounds in Common Spices. Cancer Prevention by Tea and Tea Constituents. Cancer Chemoprevention by Wine Polyphenols and Resveratrol. Flavonoids: Common Constituents of Edible Fruits and Vegetables. Carotenoids in Cancer Prevention. Chemopreventive Potential of Compounds in Cruciferous Vegetables. Phytoestrogens and Their Effects on Cancer. Diet and Cancer Prevention: Current Knowledge and Future Direction. Index.
£199.50
Taylor & Francis Inc Treatments from Toxins
Book SynopsisAs little as two decades ago, deliberately injecting botulinum toxin into patients would have seemed foolhardy at best and criminal at worst. The increased clinical use of botulinum toxins has expanded the body of knowledge available on the structure and function of these proteins. This knowledge can be applied to topics as varied as therapies based on the endopeptidase activity of the toxins, vaccine development, protection against botulism, and vectors for neuronal drug delivery. Based on recent scientific and clinical information from top international authorities, Treatments from Toxins: The Therapeutic Potential of Clostridial Neurotoxins reviews the status of current research and development and identifies significant developments. Drawing on their vast experience in this field, the editors present the basic background of the bacteriology and genetics of the neurotoxigenic clostridia, a history of the discovery of the neurotoxins, and an overview of the tetanus and botTable of ContentsIntroduction and Historical Perspective. Three-Dimensional Protein Structures of Light Chains of Botulinum Neurotoxin Serotypes A, B, and E and Tetanus Neurotoxin. Mechanisms of Actions of Neurotoxins. Vaccines to Protect against Neurotoxins. Inhibitors of Clostridial Neurotoxin Proteinase Activities. Introduction to Clinical Use of Botulinum Neurotoxins. Expanding Clinical Uses of Botulinum Neurotoxins. Development of Therapeutics Based upon Clostridial Endopeptidase Activity. Use of Neurotoxins as Drug Delivery Systems. Conclusions and Future Perspectives: Botulinum Neurotoxins as Paradigms for Development of Microbial Effector-Derived Drugs. Index.
£237.50
Taylor & Francis Inc Cell Death During HIV Infection
Book SynopsisThis work provides the first comprehensive compendium of the progress made in understanding the process of cell death related to HIV and the potential breakthroughs in treatment that offer much promise. Combining the work of more than two dozen top researchers, this seminal volume provides clinicians and researchers with an excellent reference while also serving as an incubator to stimulate future research. It explains the fundamental biology involved with apoptosis, explains its clinical impact in HIV, and examines the newest therapeutic approaches.Table of ContentsSection 1 Basic Concepts Chapter 1 Lentiviral Biology and Cell Death Chapter 2 Regulation of Apoptosis Chapter 3 Approaches Used to Detect Apoptosis Chapter 4 Consequences of HIV Infection on Thymus Function and T Cell Development Chapter 5 Deadly Intentions: Apoptosis in the Peripheral Immune System Section 2 Mechanisms of HIV-Associated Cell Death Viral Factors Chapter 6 Cell Death in HIV Infection: gp120 Chapter 7 Vpr Chapter 8 Interference of the Nef Protein of HIV-1 with Pro- and Antiapoptotic Pathways of T Cells Chapter 9 HIV-1 Tat and Apoptotic Death Chapter 10 HIV Protease (PR) and Cell Death Immune Mechanisms Chapter 11 Immune Activation Chapter 12 Impairment of HIV-Specific Immune Effector Cell Function Infected vs. Uninfected Death Chapter 13 Mechanisms of HIV-Infected vs. Uninfected T Cell Killing Chapter 14 Elevated Apoptosis of CD8+ T Lymphocytes during HIV-1 Infection Chapter 15 Autologous Cell-Mediated Killing Chapter 16 Molecular Mechanisms of HIV-1 Syncytial Apoptosis Chapter 17 Nonapoptotic HIV-Induced T Cell Death Chapter 18 Apoptosis in Organ Culture and Animal Models of HIV Disease Section 3 Clinical Consequences of HIV-Induced Cell Death Chapter 19 T Cell Dynamics and the Role of Apoptosis in HIV Infection Chapter 20 Alteration of the Apoptotic Pathways in the Thymus during HIV Infection Chapter 21 Correlations between Apoptosis and HIV Disease Progression Chapter 22 HIV-1 Infection and Cell Death in the Nervous System Chapter 23 Involvement of Apoptosis in Complications of HIV and Its Treatment Chapter 24 Apoptosis as a Pathogenic Mechanism of HIV-Associated Opportunistic Infections Section 4 Therapeutic Issues Chapter 25 Direct Effects of Anti-HIV Therapeutics on Apoptosis Chapter 26 HIV-1 Reservoirs and Residual Viral Replication during Highly Active Antiretroviral Therapy Chapter 27 Therapeutic Approaches to Modulation of Cell Death (non-HIV) Chapter 28 Immunotherapy of HIV Disease
£194.75
Taylor & Francis Inc Analysis of Growth Factor Signaling in Embryos
Book SynopsisDevelopmental biologists have been driven to investigate growth factor signaling in embryos in order to understand the regulatory mechanisms underlying a given developmental process. Thus, it is critical to explore the technical methods and experimental designs for growth factor signaling in embryos.Focusing on specific pathways or pathway components, Analysis of Growth Factor Signaling in Embryos provides the methods and guidelines for experimental design to study major aspects of cell signaling in vertebrate embryos. The book covers a broad range of topics in signaling and a variety of current model organisms. Section I explores specific signaling pathways or pathway components. In this section, some chapters highlight the biochemistry of signaling pathways during development, which is often distinctive from that observed in cell culture systems. Section II discusses ionic regulatory mechanisms and the two chapters in Section III examine ways of investigating gene reTable of ContentsSignals and Pathways. Ionic Signals. Transcription Regulation of Target Genes. Emerging Strategies for the Analysis of Signaling in Development. Index.
£218.50
Taylor & Francis Inc Molecular and Cellular Methods in Developmental
Book SynopsisThis new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic antisense oligonucleotides, studies of the role of cell death in abnormal development, and the identification of sparingly expressed developmental control genes are featured. This is the perfect manual for scientists trained in classical developmental toxicology who want to add molecular and cellular methods to their research.Table of ContentsPart I. Molecular Techniques -- Chapter 1. Molecular Techniques for Developmental Toxicology: An Introduction/George P Daston -- Chapter 2. Visualization of Gene Expression Patterns by In Situ Hybridization/ Urs Albrecht, Gregor Eichele, Jill A. Helms, and Hui-Chen Lu -- Chapter 3. Utilizing Transgenic Mice to Study Gene Regulation and Function/Michael R. Blackburn and Rodney E. Kellems -- Chapter 4. The Use of Antisense Oligonucleotide Technology and Mouse Whole-Embryo Culture to Study Gene Function During Organogenesis/Linda Foerst Potts and T W. Sadler -- Chapter 5. Nucleic Acid Amplification Technologies/Richard H. Finnell, Scott J. Vacha, and Scott A. Mackler -- Part II. Protein Identification -- Chapter 6. Fundamentals of Protein Identification: Biochemical and Immunological Analysis of Developmentally Altered Protein Expression/Gerald B. Grunwald -- Chapter 7. Immunohistochemistry/Philip E. Mirkes and Sally A Little -- Part III. Cellular Techniques -- Chapter 8. Cellular Techniques for Teratological Cell Death/Thomas B. Knudsen -- Chapter 9. Applications of Flow Cytometry in Developmental and Reproductive Toxicology/Kenneth H. Elstein and Robert M. Zucker -- Chapter 10. Modern Techniques for Cell Labeling in Avian and Murine Embryos/Diana K. Darnell and Gary C. Schoenwolf -- Index.
£114.00
Taylor & Francis Inc Methods in Inhalation Toxicology
Book SynopsisThis book focuses on an important aspect of the methods in laboratory animal inhalation toxicology. It is targeted to students in toxicology programs and scientists contemplating performing inhalation studies.Trade Review[The authors] have written a clearly delineated introduction, appropriate for graduate students beginning a career in laboratory-based inhalation toxicology, but equally useful for seasoned investigators whose work leads them into one or more aspects of the field."-Journal of Aerosol MedicineTable of ContentsChapter 1. Introduction/Phalen -- Chapter 2. Animal Quality and Protocol Approval/Mautz and Kleinman -- Chapter 3. Cleaning the Air/Phalen -- Chapter 4. Exposure Atmosphere Generation and Characterization/Kleinman and Phalen -- Chapter 5. Inhalation Exposure Methods/Phalen -- Chapter 6. Animal Monitoring/Mautz -- Chapter 7. Tissue Acquisition and Processing/Rasmussen -- Chapter 8. Specialized Sampling Techniques/Bhalla -- Index.
£190.00
Taylor & Francis Inc Desk Reference for Hematology
Book SynopsisA cross between a dictionary and an encyclopedia, Desk Reference for Hematology, Second Edition presents a concise yet thorough examination of hematology and its relationship with other systems and disorders. The 1500 alphabetically listed articles provide quick and easy access to expert information, the 150 tables put precise data at your fingertips, and the 100 figures are a visual tool that clarify the text. The book also includes 500 references on state-of-the-art guidelines and recent developments.See whatâs new in the Second Edition: Revised articles emphasizing genetics, physiology, pathological mechanisms Updated coverage of treatments for leukemia, lymphoma, coagulation, and thrombotic disorders Hundreds of completely new articles, new illustrations, and new explanatory diagrams as well as revised tables Completely revised, this edition covers hematopoiesis, red blood cells, granulocytes, lymphocytes, platelets and hemostasis where the respective physiology is described anemias, leukemias, lymphomas, auto-immune disorders, hemorrhagic disorders, and thrombosis where etiology, pathogenesis, diagnosis and treatment is described. The book includes coverage of blood groups and the practice of blood component therapy. The editor pays particular attention to recent developments in hematological molecular genetics and leukemogenesis. The information is cross-referenced with words highlighted in bold face within an article to indicate that further information on the subject is available under the emboldened heading. A separate table provides common abbreviations used widely throughout the text. Carefully designed for ease of use, the book provides speedy access to authoritative information on the scientific basis of blood disorders and their treatment.Table of ContentsContents are listed alphabetically by subject.
£228.00
Taylor & Francis Inc The Handbook of Microbiological Media for the
Book SynopsisResponding to an estimated 14 million cases of food-borne disease that occur every year in the United States alone, the Food and Drug Administration and US Department of Agriculture have begun implementing new regulations and guidance for the microbial testing of foods. Similarly, Europe and other regions are implementing stricter oversight, as foodborne pathogens that cause deadly diseases such as e. coli 0157:H7 have raised the stakes everywhere. Food safety scientists have acted on this growing public health risk by developing improved media for the cultivation of bacteria, fungi, and viruses, much of it geared toward specific rapid detection.Reflecting the development of these new media and the latest FDA recommendations, the second edition of the Handbook of Microbiological Media for the Examination of Foodprovides an essential resource for anyone involved with the monitoring of both food production and post-production quality control. Organized alphTrade Review“This book provides descriptions and recipes for a very wide range of media… There is also a short introduction to food microbiology. … a useful reference source in a media laboratory or departmental library…” — Alan Varnam, London Metropolitan University, in Society for General Microbiology, (SGM), current Issue, Quarterly Review"This book is undoubtedly a valuable resource for investigators of foodborne pathogens." – Christian T. K. –H. Stadtländer, University of St. Thomas, in Microbe, 2007, Vol. 2, No. 7Table of ContentsIntroduction to Food Microbiology. Alphabetical Listing of Media. Appendix. Index.
£204.25
Taylor & Francis Inc Cytokine Gene Polymorphisms in Multifactorial
Book SynopsisThe literature on cytokine genetics is vast, so vast that it is now practically beyond the time or logistical constraints of most scientists to successfully keep pace with it. A compilation of the latest research, Cytokine Gene Polymorphisms in Multifactorial Conditions brings together, reviews, and structures up-to-date information on polymorphisms in cytokine genes. It discusses haplotype structures and linkage disequilibrium patterns in cytokine gene loci; functional biological effects of polymorphisms; and genetic associations with disease. The book documents polymorphisms in the most important cytokine genes, or gene clusters, and their biological and genetic effects in a multitude of distinct multifactorial conditions. Unique to this book are the disease-centered chapters examining the role of cytokine gene polymorphisms in a multitude of multifactorial conditions. The conditions include autoimmune or chronic inflammatory diseases, cardiovascular disease, infectious diTrade Review"As this volume so capably demonstrates, genetic variation in cytokines, the messengers of the immune system, and their receptors is now recognized as playing an important role in disease susceptibility and outcome...This book is a timely anthology of knowledge, techniques as well as informed speculation…The chapters in this book represent an excellent and timely means of addressing questions related to the study of cytokine gene polymorphisms and will serve as an important reference work.."- From the foreword by Grant Gallagher and Michael F. Seldin, Editors, "Genes and Immunity", March 2006Table of ContentsGeneral Concepts. Cytokine Gene Polymorphisms. Polymorphic Cytokine Networks in Multifactorial Conditions.
£194.75
Taylor & Francis Inc Immunotoxicology and Immunopharmacology
Book SynopsisContinuing the tradition set by the first and second editions, each a bestseller in its own right, the third edition of Immunotoxicology and Immunopharmacology provides reviews of environmental agents, updated to reflect the latest information on how these agents influence immune system function and health. For the first time in the book's history, an entire section covers the phylogeny and ontogeny of the immune system, spanning levels of biological complexity from earthworms to marine mammals.Table of ContentsImmunotoxicology and Hazard Identification. Immunopharmacology and Immunotoxicology of Therapeutics. Environmental Agents. Immunotoxicology in the Lung. Developmental Immunotoxicity. Wildlife Immunotoxicology. Autoimmunity and Autoimmune Diseases. Neuroimmunology. Allergy and Hypersensitivity.
£166.25
Taylor & Francis Inc Adenosine Receptors
Book SynopsisAfter a century of research, several lines of evidence now indicate that the ability of adenosine to directly control inflammatory cells has a major impact on the functions of the inflammatory and immune systems. Consequently, many promising therapeutic approaches are beginning to emerge that focus on the modulation of adenosine, including the development of compounds that interfere with the breakdown of adenosine, as well as specific agonists and antagonists of various adenosine subtypes. Some of these compounds have already entered clinical trials. While information on the role of adenosine is growing rapidly, until now it has remained scattered in the literature.Edited by three pioneering researchers in the field, Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases presents the first single volume compilation of reviews on how adenosine, acting on its cellular receptors, regulates immune responses. The book is organized to provide the readeTrade Review"… written by a number of prime experts in the field. … highly recommended to readers who are interested in the pharmacology of adenosine receptors." – Christa E. Muller, PharmaCenter Bonn, Germany in ChemMedChem, 3, 2008Table of ContentsIntroduction. Adenosine Receptor Pharmacology. Regulation of Macrophage Function by Adenosine Receptor Engagement. Anti-inflammatory Effects of Inosine. Regulation of Adenosine Receptor Expression in Inflammation. A2a Adenosine Receptors in Ischemia. Adenosine, Toll-like Receptors, and Angiogenesis. Adenosine Signaling and Lung Fibrosis. Adenosine and Endothelial Cell Function. Regulation of Peripheral Inflammation by Spinal Adenosine. Adenosine, Hypoxia, and Immunity. Adenosine Regulation of Dendritic Cell Function. A2b Receptors in Intestinal Epithelial Cells. Adenosine Receptors in Multiple Sclerosis. Adenosine Receptors in Infectious Disease. Adenosine, Tumors, and Immunity. Adenosine in Atherosclerosis. Adenosine in Neuroimmunomodulation.
£237.50
Taylor & Francis Inc Posttranslational Modifications of Proteins
Book SynopsisPost-Translational Modifications of Proteins discusses several important topics of interest to researchers and students in protein chemistry and biochemistry, including the occurrence and function of hydroxylated residues and the three enzymes required for their formation; the damaging effects of reactions between sugars and proteins; ADP-riboosylation of proteins outside the nucleus; and Monod, Wyman, and Changeux's concerted model for allosteric control of enzyme activity exemplified by studies on glycogen phosphorylase. The application of Fast Atom Bombardment Mass Spectometry (FAB-MS) to studies on the structure and biosynthesis of various oligosaccharide moieties in protein is examined, and the understanding of the structural diversity and function of glycoprotein oligosaccharides is discussed in this volume.Table of ContentsHydroxylation of Proline and Lysine Residues in Collagens and Other Animal and Plant Proteins (K.I. Kivirikko, R. Myllyla and T. Pihlajaniemi). Advanced Glycosylation Endproducts (R. Bucala, H. Vlassara and A. Cerami). Rabbit Muscle Glycogen Phosphorylase b. The Structural Basis of Activation and Catalysis (N.G. Oikonomakos, K.R. Acharya and L.N. Johnson). Mono-ADP-Ribosylation of Proteins (S. van Heyningen). Glycan Structures in Glycoproteins and Their Analysis by Fast Atom Bombardment Mass Spectrometry (A. Dell, R.A. McDowell and M.E. Rogers). Glycoproteins of Mammalian and Avian Cells (F.W. Hemming).FEATURES:
£427.50
Taylor & Francis Inc Kinetic Models of Trace Element and Mineral
Book SynopsisKinetic models are becoming standard tools in the research of biological systems. They are used to represent hypotheses, analyze data, and design experiments to maximize the information obtained from a study. Kinetic Models of Trace Element and Mineral Metabolism During Development describes models for calcium, chromium, copper, iron, iodide, lead, mercury, selenium, zinc, and others in health and disease.Table of ContentsPregnancy and Lactation: Use of Mineral Stable Isotopes in the Study of Nutrient Homeostasis During Human Pregnancy and Lactation. Kinetic Overview: Modeling Calcium Metabolism in Pregnant and Lactating Cows. Calcium Metabolism in Pregnancy and Lactation: An Individual Study. Copper Metabolism in Dairy Cows: Development of a Model Based on a Stable Isotope Tracer. Neonates and Children: Zinc Kinetics in Humans. Stable Isotope Studies of Zinc Kinetic Metabolism in Infants. Determination of Mineral Absorption by Very Low Birthweight Preterm Infants with the Stable Isotope Extrinsic Tag Approach. Adolescents and Adults: Determination of Requirements. Contributions of Mathematical Models to Understanding of Human Iodide Metabolism. Zinc that Exchanges with Zinc in Plasma Within Two Days: Variation with Dietary Zinc. Calcium Metabolism in Adolescents. Stable Isotopes of Copper, Molybdenum, and Zinc Used Simultaneously for Kinetic Studies of Their Metabolism. Reference Values for Trace Elements in Human Clinical Specimens: With Special Reference to Biomonitoring and Specimen Suitability. Disorders: Studies of Calcium Metabolism in Children with Chronic Illnesses. Historical Overview of Copper Kinetics. Compartmental Analysis of Intestinal Iron Absorption and Mucosal Iron Kinetics. Chromium (III) Metabolism in Diabetic Patients. A Calcium-Based Model of Human Lead Kinetics. Environmental Health: Some Constitutive Modifiers of the Kinetic and Dynamic Behavior of Non-Essential Metals. An Overview of Selenium Kinetics in Humans. The Kinetics of Intravenously Administered Inorganic Mercury in Humans. Calcium Metabolic Dynamics: Overview of Calcium Metabolic Dynamics. Interpretation of Stable Isotope Studies of Calcium Absorption and Kinetics. Calcium Homeostasis-An Old Problem Revisited. Generalized Stochastic Compartmental Models of Calcium Metabolism. Frequency Response of the Calcium Control System. Regulation in Oscillatory Models. Optimal Sampling for the Determination of
£194.75
Taylor & Francis Inc The Amphipathic Helix
Book SynopsisThe Amphipathic Helix is a comprehensive volume discussing amphipathic helices in systems as diverse as serum lipoproteins, lung surfactant, cytotoxic peptides, ion channels, mitochondrial targeting, peptide hormones, G proteins, T-cell recognition, DNA binding proteins, and antifreeze proteins. The book also includes general introductory material that defines amphipathic helices, discusses methods to identify amphipathic helical segments from the amino acid sequence of a protein, illustrates how amphipathic helices can be used in the de novo design of peptide and protein structures, and describes how these helices stabilize protein structures. There is also a section on techniques to determine helix orientation in a membrane environment using polarized attenuated total reflection infrared spectroscopy or solid state NMR spectroscopy. Recent developments on all these topics have been discussed by leading experts in this reference for researchers and students in biochemistry, biophysicsTable of ContentsIntroduction and Overview (R.M. Epand). Design of Amphipathic Helices: Computational Techniques to Predict Amphipathic Helical Segments (I.E. Auger). Amphipathic Helices in Designed Peptide Structures (J.M. Stewart). The Role of Amphipathic Helices in Stabilizing Peptide and Protein Structure (C.T. Mant, N.E. Zhou, and R.S. Hodges). Experimental Methods for Studying Amphipathic Helices in Membranes: Polarized Attenuated Total Reflection Infrared Spectroscopy as a Tool to Investigate the Structure and Orientation of Amphipathic Peptides in a Lipid Bilayer (E. Goormaghtigh, V. Cabiaux, and J.-M. Ruysschaert). NMR Spectroscopy of Amphipathic Helical Peptides in Membrane Environments (S.J. Opella, J. Gesell, and B. Bechinger). Biological Roles for the Interactions of Amphipathic Helices with Lipids: An Atlas of the Amphipathic Helical Domains of the Human Exchangeable Plasma Apolipoproteins (G.M. Anantharamaiah, M.K. Jones, and J.P. Segrest). Amphipathic Helical Segments in Lung Surfactant Proteins (A.J. Waring, L.M. Gordon, H.W. Taeusch, and R. Bruni). The Amphipathic Helix in Cytotoxic Peptides (I. Cornut, E. Thiaudière, and J. Dufourcq). Amphipathic Helices and Ion Channels (J. Tomich). Other Biological Roles for Amphipathic Helices in Membrane-Related Phenomenon: The Amphipathic Helix in Mitochondrial Targeting Sequences (D. Roise). Amphiphilic Helices in Neuropeptides (J.W. Taylor). Activation of G Proteins by Membrane Receptors and Peptides. Putative Role for Amphipathic Helices (M. Mousli and Y. Landry). The Amphipathic Helix as a Structural Feature Involved in T-Cell Recognition (J.L. Cornette, H. Margalit, C. DeLisi, and J.A. Berzofsky). Other Biological Roles of Amphipathic Helices: Amphipathic Helices in Proteins that Bind to DNA: The bZIP and bHLH-Zip DNA Binding Motifs (C.R. Vinson). Protein-Ice Interactions: Antifreeze Proteins (D.S.C. Yang).
£308.75
Taylor & Francis Inc The Experimental Animal in Biomedical Research
Book SynopsisThe Experimental Animal in Biomedical Research provides a concise, useful survey of knowledge regarding laboratory animal care. Volume I addresses researchers who use animals and focuses on how to maximize the welfare of animals used in research.
£593.75
Taylor & Francis Inc Cell Interactions in Atherosclerosis
Book SynopsisCell Interactions in Atherosclerosis covers the scientific foundations of the most important disease inflicting the developed world today. It presents a collection of topical aspects on the general theme of cell interactions in atherosclerosis, providing authoritative, up-to-the-minute accounts of how new developments in cell biology have advanced our understanding of these cellular interactions. The book is amply illustrated with electron micrographs and light micrographs incorporating modern cytochemical procedures. Cell Interactions in Atherosclerosis will interest all medical and scientific professionals dealing with atherosclerosis and heart disease.Table of ContentsConstituents of the Arterial Wall and Atherosclerotic Plaque: An Introduction to Atherosclerosis (Nicholas J. Severs and Horst Robenek). Three-Dimensional Organization of the Intima of Rabbit Aorta in Early Atherosclerotic Lesion Development as Viewed by Quick-Freeze, Deep-Etch Electron Microscopy (Joy S. Frank and Patricia F.E.M. Nievelstein). Renal Transplant Arteriopathy; Similarities to Atherosclerosis (Ekkehard Vollmer and Albert Roessner). Collagens and Collagen Synthesis in the Atherosclerotic Vessel Wall (Jürgen Rauterberg and Elisabeth Jaeger). Regulation of Biosynthetic Activity in Aortic Smooth Muscle Cells by Extracellular Matrix Components (Michael Thie). Vascular Cell Responses to Injury: Modulation by Extracellular Matrix and Soluble Factors (Joseph A. Madri and Leonard Bell). Cytochemical Characterization and Mapping of Glycoconjugates in Arterial Tissues and Vascular Cell Cultures by Light and Electron Microscopy (Wolfgang Völker). Role of Modified Lipoproteins in Atherosclerosis (Wulf Palinksi). Characterization of Lipoprotein Metabolism in Cells Isolated from Atherosclerotic Arteries (Olli Jaakkola). Endocytosis of Lipoproteins and Cholesterol Homeostasis (Horst Robenek and Nicholas J. Severs). c. 250 pp., 6-1/8 x 9-1/4, due September 1992, ISBN 0-8493-5505-2.FEATURES:
£403.75
Taylor & Francis Inc Epidermal Langerhans Cells
Book SynopsisEpidermal Langerhans Cells focuses on epidermal Langerhans cells (LCs) and the important role they play in the induction of contact hypersensitivity and graft rejection. This in-depth work discusses how these antigen-presenting cells are modulated by various physicochemical agents (such as UV light) and how they can be infected by the AIDS virus. It also reveals that cytokines mediate their development into potent T cell-stimulatory dendritic cells. This comprehensive review covers important experimental details and methods, and fascinating information on LCs. It also provides an overview of the immune system as it relates to the skin in health and disease. This up-to-date publication is an indispensable resource for all investigative and clinical dermatologists, as well as immunologists interested in antigen-presenting cells.Table of ContentsThe Fascinating Story That Began in 1868. Origin, Cell Lineage, Ontogeny, Tissue Distribution, and Kinetics of Langerhans Cells. Identification and Phenotype of Epidermal Langerhans Cells. Structural Organization and Biological Properties of Langerhans Cells. Enrichment of Epidermal Langerhans Cells. Langerhans Cells as Antigen-Presenting Cells. Langerhans Cells as Immature Dendritic Cells. Epidermal Cell Derived Secretory Regulins. The Influence of Ultraviolet Radiation and Other Physical and Chemical Agents on Epidermal Langerhans Cells. Tolerizing Versus Sensitizing Signals Derived from the Epidermis. Role of Langerhans Cells in Disease. Index.
£999.99
Taylor & Francis Inc Endothelin Receptors
Book SynopsisSince the discovery of endothelin, major advances have been made in understanding the molecular structure and function of the endothelin receptors. At least two subtypes of receptors, designated ETA and ETB, have been identified through biochemical and pharmacological techniques. These subtypes are cloned and expressed and additional subtypes appear to exist. The biochemical events involved in the signal transduction processes that ultimately activate the cellular machinery involved in the end-organ responses are presented, as are the mechanisms by which the receptors recognize specific and different G-proteins. Functions mediated by the receptors at the cellular, tissue and, organ level are reviewed in detail, as well as the roles that they may play a part in the physiologic and pathophysiologic processes in animals and in humans.This book is unique in its breadth of scope. The most recent and important advances, from the intracellular level of the nucleus to the functional effTrade Review"This book is recommended as an addition to the libraries of institutions and individual researchers actively studying the physiological and/or pathophysicological role of endothelin."- J. Med. Chem., 1996, 39(3)Table of ContentsIntroduction: Endothelin Receptors, E.H. Ohlstein and R.R. Ruffolo, Jr.Endothelin Receptor Subclassification, E.H. Ohlstein, P. Nambi, and R.R. Ruffolo, Jr.Molecular Biology of Endothelin Receptors, D.J. Bergsma, N. Elshourbagy, and C. Kumar Signal Transduction Processes Involved in Endothelin-Mediated Responses, P. Nambi, C. Kumar, and E.H. OhlsteinEndothelin Receptor Antagonists, J.D. Elliott, M.A. Lago, and C.E. PeishoffFunctions Mediated by Peripheral Endothelin Receptors, E.H. Ohlstein, S. Douglas, D.P. Brooks, D.W.P. Hay, G.Z. Feuerstein, and R.R. Ruffolo, Jr.Endothelin in the Central Nervous System, R.N. Willette, G.Z. Feuerstein, and F.C. BaroneThe Role of Endothelin in Human Disease: Implications and Potential Therapeutic Intervention, D.K. Jorkasky, D.W.P. Hay, and M.I. FreedIndex
£427.50
Taylor & Francis Inc Immune System Accessory Cells
Book SynopsisImmune System Accessory Cells provides a comprehensive survey of all types of antigen-presenting and accessory cells. Macrophages are emphasized through descriptions of different types of endocytosis, other major properties, and all basic and new information concerning macrophages as antigen-presenting cells. Other topics covered include the impact of the immunodeficient state on accessory functions, the evolutionary emergence of accessory functions, and the role of various cell types in defense reactions in major assemblages of Metazoa. The book also presents a chapter describing the phylogenetic aspects of accessory functions, which traces the first accessory cells during the evolution of living matter.Immune System Accessory Cells is an excellent reference for immunologists, cell biologists, and others interested in developing an understanding of the roles of accessory cells in all facets of immune reactions.Table of ContentsEvolution of Immune Accessory Functions (P. Síma and V. Vetvicka). Ontogeny of the Stroma of Lymphoid Tissues (M. Holub). Endocytosis (V. Vetvicka). Antigen Processing (O. Werdelin and S. Mouritsen). Macrophages (V. Vetvicka and L. Fornusek). Antigen Presentation by Macrophages and Dendritic Cells (V. Vetvicka and L. Fornusek). Dendritic Cells as Accessory Cells (J. G. Tew, G.F. Burton, A. Masuda, Z.F. Kapasi, and A.K. Szakal). Langerhans' Cell Surface Molecules Involved in Accessory Functions (G.C. Mudde, T.T. Hansel, and C.A.F.M. Bruijnzeel-Koomen). The Dual Role of B Cells in Antigen Presentation: Induction and Regulation of Immune Responses (L. Leserman and J.-C. Grivel). Cell-Cell Interactions: In Situ Studies of Splenic Humoral Immune Responses (J.D. Laman, A.J.M. Van den Eertwegh, E. Claassen, and N. Van Rooijen). The Role of Accessory Cells in Positive and Negative Selection in the Thymus (P. Naquet and H. Lepesant). Function of Neutrophils in Host Defense and Immunity (G.D. Ross). Molecular Biology of Antigen Presentation (D. Gerlier, V. Calin-Laurens, P. Bertolino, and C. Rabourdin-Combe). Mediators Involved in Accessory Functions (U. Yamashita). Antigen Processing in B Lymphocytes: A Role for Stress Proteins (D.C. DeNagel and S.K. Pierce). Accessory Cells in Murine Immunodeficiencies (V. Vetvicka and L. Fornusek). Index.
£308.75
Taylor & Francis Inc ImmunoGold Electron Microscopy in Virus Diagnosis
Book SynopsisThis book presents a wide variety of immuno-gold techniques for use in virus diagnosis and research. Protocols are presented for state-of-the-art techniques, including in situ hybridization, freeze substitution, and the utilization of ultra-small probes and replicas for use by virologists and electron microscopists identifying and studying viruses, their components, and replication in cells. The procedures are described by eminent scientists and are pertinent to both experienced researchers and newcomers to this field who are interested in the localization of low antigenic mass structures.Table of ContentsImmuno-Gold Electron Microscopy for Virus Diagnosis: Immune Complexing (E.L. Palmer and M.L. Martin). Solid-Phase Immune Electron Microscopy of Virus Preparations (R.G. Milne). Gold Labeling in Negative Stain Immune Electron Microscopy (P.J.C. Dopping-Hepenstal and J.E. Beesley). The Grid-Cell-Culture Technique (A.D. Hyatt and B.T. Eaton). Use of Microspheres for Immune Scanning Electron Microscopy (J.P. Andersson, U.G. Andersson, and A. Sonnerborg). Immuno-Gold Electron Microscopy in Virus Research: The Colloidal Gold Probe, An Overview of Its Application in Viral Cytochemistry (S. Garzon and M. Bendayan). Detection of Viral and Cellular Structures by Post-Embedding Immunocytochemistry (G.N. Williams and P. Faulkner). Multiple Labeling of Thin Sections (M. Nielsen and L. Bastholm). Immuno-Gold Replica Technique for Study of Virus-Infected Cells (K. Mannweiler, H. Hohenberg, G. Rutter, and W. Bohn). Detection and Analysis of Viral Proteins by Immuno-Gold Labeling (K.G. Murti). Cryo-Sectioning (H.K. Hagler). Improvements of Immuno Dection Using Ultra-Small Gold Probes and Cryosections (J.L.M. Leunissen and P. van de Plas). Freeze Substitution in Virus Research: A Preview (H. Schwartz, H. Hohenberg, and B.M. Humbel). Ultrastructural In Situ Hybridization Using Immuno-Gold (G.L. Bassell and R.H. Singer). Use of Colloidal Gold and Silver Enhancement in Scanning Electron Microscopy (A.D. Hyatt and S.M. Brookes).
£308.75
Taylor & Francis Inc Proteins and Nonprotein Nitrogen in Human Milk
Book SynopsisFor the first time, an entire publication has been dedicated to providing a critical review of the identification and analysis of the milk specific proteins such as lactalbumin, lactoferrin and casein; the non-milk specific proteins such as plasma and membrane proteins; and the minor nitrogen-containing components such as enzymes, hormones, and growth factors. Biological roles, whether nutritional, endocrinological or immunological, of the specific nitrogen compounds in mammary milk production and/or growth and development of the breast-fed infant are also presented. Identification of the molecular weight compounds that have led to questions about their function in milk and their inclusion in modern infant formulas is thoroughly discussed and of great value to scientists in sub-specialties of biochemistry, nutrition, physiology and immunology, as well as to pediatric practitioners with primary interests in the infant food industry, academia, or clinical nutrition. The thoroughness oTable of ContentsSection A: Overview, Chapter 1 Overview: The Biochemistry of Nitrogen-Containing Compounds in Human Milk and Their Physiological Significance, Section B: Proteins in Human Milk, Chapter 2 Casein Micelles and Casein Subunits in Human Milk, Chapter 3 Whey Proteins in Human Milk, Chapter 4 Immunoglobulins in Human Milk, Chapter 5 Peptide Hormones and Hormone-Like Substances in Milk, Chapter 6 Enzymes in Human Milk, Chapter 7 Growth Factors in Human Milk: Sources and Potential Physiological Roles, Chapter 8 Fat Globule Proteins, Section C: Non-Protein Nitrogen in Human Milk, Chapter 9 Non-Protein Nitrogen Components in Human Milk: Biochemistry and Potential Functional Role, Section D: Physiological Significance of the Nitrogen Composition of Human Milk, Chapter 10 Protein Quantity and Whey-Casein Ratio in Infant Formulas, Chapter 11 Is Taurine an Essential Nutrient for Neonates?, Chapter 12 Excretion of Human Milk Proteins by Term and Premature Infants, Chapter 13 Amino Acid Metabolism in Human Milk-Fed and Formula-Fed Term Infants, Chapter 14 Amino Acid Metabolism and Requirements of the Premature Infant: Is Human Milk the “Gold Standard”?, Chapter 15 Nonimmunoglobulin Components in Human Milk — Candidates for Prophylaxis Against Infantile Infections, Chapter 16 Milk Lipases and In Vivo Lipolysis, Index
£475.00
Taylor & Francis Inc Protein Methylation
Book SynopsisThis significant volume provides reviews on protein methylation reactions which occur ubiquitously in nature. Written in a comprehensive style, this work covers knowledge on the natural occurrence of methylated amino acids, their chemical synthesis, plus the enzymology, biological regulator, and biological significance of free methylated amino acids. It also includes various specific biological systems where posttranslational methylation reactions have been demonstrated. This text is unique because the chapters are critically reviewed by authorities in each respective field. This well-written volume is an excellent reference to researchers as well as graduate students interested in post-synthetic modifications of macromolecules.Table of ContentsThe Occurrence and Analysis of Methylated Amino Acids. Reevaluation of the Enzymology of Protein Methylation. Calmodulin and Protein Methylation. Cytochrome c Methylation. Protein-Arginine Methylation: Myelin Basic Protein as a Model. Amino Acid Sequence of Arginine Methylation Sites. Histone Methylation and Gene Regulation. Post-translational Methylation of Histones and Heat Shock Proteins in Response to Heat and Chemical Stresses. Ribosomal Protein Methylation. The Function and Enzymology of Protein D-Aspartyl/L-Isoaspartyl Methyltransferases in Eukaryotic and Prokaryotic Cells. Identities, Origins, and Metabolic Rates of the Substrates for Eukaryotic Protein Carboxyl Methyltransferases. Protein Carboxylmethylation in Nervous Tissues. Protein Methylesterase from Mammals. Chemotactic Methylation in Bacillus subtilis. The Chemotaxis-Specific Methylesterase of Enteric Bacteria. Role of Protein Carboxyl Methylation in Bacterial Chemotaxis. Self-Methylation by Suicide DNA Repair Enzymes. Natural and Synthetic Analogues of S-Adenosylhomocysteine and Protein Methylation. Update on the Synthesis of N-Methylamino Acids. Biological Effects of Methylated Amino Acids. Methylated Polypeptide Models. Nonenzymatic Protein Methylation and Its Biological Significance
£475.00
Taylor & Francis Inc Soil Solarization
Book SynopsisSoil Solarization describes the principles and technology of soil solarization and the use of soil solarization for different crops and cropping systems. The book evaluates and interprets the extensive amount of literature available on soil solarization in relation to climatic effects and changes in populations of soil-borne microorganisms and weeds. It also compares the advantages and disadvantages of soil solarization with other methods of soil disinfestation, such as soil steaming and fumigation. Soil Solarization explores the effects of soil solarization, covering such points as biological control, changes in soil chemistry involving mineral elements, as well as other changes, such as soil salinity and soil structure. It is suitable for solarizers, researchers working with soil-borne pathogens and soil microbiology, plant protection experts, and other plant researchers and extension specialists.Table of ContentsSECTION I: SOIL SOLARIZATION AS A CONTROL METHOD: AN INTRODUCTION (Jaacov Katan and James E. DeVay). Population Dynamics of Plant Pathogens and Associated Organisms in Soil in Relation to Infectious Inoculum (Gary J. Griffin and Ralph Baker). Soil Solarization: Historical Perspectives, Principles, and Uses (Jaacov Katan and James E. DeVay). Soil Solarization: Pathogen and Disease Control and Increases in Crop Yield and Quality - Short- and Long-Term Effects and Integrated Control (James R. Davis). Management of Phytoparasitic Nematodes by Soil Solarization (James J. Stapleton and Charles M. Heald). Weed Control by Solarization (Clyde L. Elmore). SECTION II: MECHANISMS: PHYSICAL, MICROBIAL, AND CHEMICAL CHANGES IN THE SOLARIZED SOIL - AN INTRODUCTION (Jaacov Katan and James E. DeVay). Physical Principles of Solar Heating of Soils by Plastic Mulching in Field and in Glasshouses and Simulation Models (Y. Mahrer). Mechanisms of Pathogen Control in Solarized Soils (James E. DeVay and Jaacov Katan). Chemical, Physical, and Microbial Changes Related to Plant Growth in Disinfected Soil (Yona Chen, A. Gamliel, James J. Stapleton, and Tsila Aviad). Pesticide Behavior in Solarized and Disinfected Soils (Nadav Aharonson and Jaacov Katan). SECTION III: TECHNOLOGY AND APPLICATION: AN INTRODUCTION (Jaacov Katan and James E. DeVay). Plastic Chemistry and Technology as Related to Plasticulture and Solar Heating of Soil (C. Stevens, V.A. Kahn, J.E. Brown, G. Hochmuth, W.E. Splittstoesser, and D.M. Granberry). The Technology of Soil Solarization (Avshalom Grinstein and Amotz Hetztroni). Economic Evaluation of Soil Solarization and Disinfestation (D. Yaron, A. Regev, and R. Spector). SECTION IV: IMPLEMENTATION OF SOIL SOLARIZATION IN DIFFERENT CROPPING SYSTEMS: AN INTRODUCTION (Jaacov Katan and James E. DeVay). Soil Solarization in Israel (A. Grinstein and R. Ausher). Soil Solarization in Greece (E.C. Tjamos). Soil Solarization in Japan (Seizo Horiuchi). Soil Solarization in Southern E
£308.75
Taylor & Francis Inc HighThroughput Lead Optimization in Drug
Book SynopsisA Single Source on Parallel Synthesis for Lead Optimization The end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening. Over time, it became clear that more thought in the design phase of library development is necessary to generate high quality hits. More recently, the use of parallel synthesis techniques has shifted to applications beyond screening collections. Exploring the nuances of this technology, High-Throughput Lead Optimization in Drug Discovery describes the application of parallel synthesis to lead optimization and the design and synthesis of targeted libraries. Examine Case Studies that Cover a Range of Different Biological Targets Featuring real-world examples and contributions from well-known scientists, the book explores the shift to conducting parallel lead optimization in-house while outsourcing most of the screening libraries synthesis. Trade Review"Overall, this book is a successful attempt to provide in one volume many illustrative examples in this evolving field and it presents a wealth of information on topics that demonstrate the versatility and power of the technology." – Jan W. F. Wasley, Simpharma LLC, in Journal of Medicinal Chemistry, 2008, Vol. 51, No. 23Table of ContentsIntroduction and Review. Application of Parallel Synthesis to the Optimization of Inhibitors of the ZipA-FtsZ Protein-Protein Interaction. Case Studies of Parallel Synthesis in Hit Identification, Hit Exploration, Hit-to-Lead, and Lead Optimization Programs. A Successful Application of Parallel Synthesis to Computer-Assisted Structural Optimization of New Leads Targeting Human Immunodeficiency Virus-1 Reverse Transcriptase: The Case of Acylthiocarbamates and Thiocarbamates. How High-Throughput Medicinal Chemistry Can Expedite Lead Discovery, Lead Optimization, and Beyond. Rapid Lead Identification of Inhibitors of Adenine Nucleotide Translocase: A Case Study of Applying Combinatorial Chemistry Techniques in Drug Discovery. Parallel Synthesis of Anticancer, Antiinflammatory, and Antiviral Agents Derived from L-and D-Amino Acids. Application of Solid-Phase Parallel Synthesis in Lead Optimization Studies. High-Throughput Solid-Phase Synthesis of Nucleoside-Based Libraries in the Search for New Antibiotics.
£175.75
Taylor & Francis Inc Comprehensive Handbook of Chemical Bond Energies
Book SynopsisUnderstanding the energy it takes to build or break chemical bonds is essential for scientists and engineers in a wide range of innovative fields, including catalysis, nanomaterials, bioengineering, environmental chemistry, and space science. Reflecting the frequent additions and updates of bond dissociation energy (BDE) data throughout the literature, the Comprehensive Handbook of Chemical Bond Energies compiles the most recent experimental BDE data for more than 19,600 bonds of 102 elements. The author organizes the data by bond type, functional group, bond order, bond degree, molecular size, and structure for ease of use. Data can also be located using the Periodic table. The book presents data for organic molecules, biochemicals, and radicals as well as clusters, ions, hydrogen- and surface-bonded species, van der Waals complexes, isotopic species, and halogen-clusters/complexes. It also introduces entirely new data for inorganics and organometallics. The final chapter summTrade Review"This book offers quick access to experimental BDE data in the most inclusive, well-organized, and up-to-date collection available today." – In Anticancer Research, September/ October 2007, Vol. 57, No. 5ATable of ContentsOrganic and Non-metallic Compounds, and Their Radicals. Metallic Compounds, Ions, Complexes, and Cluster. Non-Metallic Ions, Complexes, and Clusters. Enthalpy of Formation of Radicals and Ions, References, and Indexes.
£570.00
Taylor & Francis Inc Applied Biomedical Microbiology
Book SynopsisFrom the slippery covering on rocks in a stream, to the clogging slime in a bathtub drain, biofilms are present in everyday life in a variety of forms. This seemingly harmless build-up also accounts for 80 percent of all microbial infections. With chapters authored by experienced contributors from academia and industry, Applied Biomedical Microbiology: A Biofilms Approach demonstrates effective ways to combat the health and economic havoc that biofilms are wreaking, while also tapping into their positive potential. Replete with Tables and Illustrations, Many in ColorUnder the editorial guidance of esteemed industrial microbiologist Dr. Daryl Paulson, this book presents an in-depth discussion of medically challenging biofilms. It provides a solid foundation in the basic microbiology of biofilms and then goes on to discuss the biofilms associated with medical devices, catheters, and dental unit water lines as well as those that impact cardiovasTable of ContentsBiofilms before biofilms. Efficacy of preoperative antimicrobial skin preparation solutions on biofilm bacteria. Oral biofilms and transferable antibiotic resistance. Inhibition of foundation colonization of biofilm by surface modification with organofunctional silanes. Biofilms and device implants. A simulated-use evaluation of a strategy for preventing biofilm formation in dental unit waterlines. Biofilms in hospital water distribution systems. Disinfection and its influence on the ecology of biofilms in drinking water distribution systems. Understanding the importance of biofilm growth in hot tubs.
£199.50
Taylor & Francis Inc Metabolism of Brain Peptides
Book SynopsisMetabolism of Brain Peptides discusses neuropeptide metabolism in light of recent research. It describes the processing mechanisms in the production of biologically active peptides. It details distribution of the variety of neuropeptides in the brain and comprehensively reviews the effects of these neuropeptides on behavioral and physiological functions. The book also examines termination mechanisms for the biological activities of neuropeptides in light of recent knowledge of their distribution, their receptors and their possible inactivation enzymes in various functional regions of the brain and at the blood-brain barrier.Table of ContentsThe Production of Biologically Active Peptides in Brain Tissues, J. Donlon, University College of Galway, Republic of IrelandSpecific Aspects of Peptide ProteinsPeptide AmidationBiological Activity of Peptides in Brain Tissues, F. Roman, Institut de Recherche Jouveinal, FranceIntroductionNeuropeptide YCalcitonin-gene Related PeptideCholecystokininGalaninNeurotensinNeuropeptide Receptor-Ion Channel Coupling in the Mammalian Brain, P. Boden, Parke-Davis Neuroscience Research Centre, Cambridge, EnglandMethodological ApproachesNeuropeptides and Ion Channels: Mechanistic StudiesInactivation of Thyrotropin Releasing Hormone (TRH). The TRH-Degrading Enzyme as a Regulator and/or Terminator of TRH Signals, K. Bauer, Max-Planck-Institute for Experimental Endocrinology, Hannover, GermanyCharacteristics of the TRH-Degrading Serum Enzyme and the membrane-Bound TRH-Degrading EnzymeCellular and Subcellular LocalizationPurification and CloningHormonal Regulation of the TRH-Degrading EnzymesIntracellular Peptide Turnover: Properties and Physiological Significance of the Major Peptide Hydrolases of Brain Cystosol, S. Wilk, Mount Sinai School of Medicine, New York, New YorkEndopeptidasesOligopeptidasesExopeptidasesOmega Peptidases
£999.99
Taylor & Francis Inc Macroelements Water and Electrolytes in Sports
Book SynopsisAddresses the relationship of macroelement needs and interactions to sports and exercise. This book examines the connection between exercise and sports activities and the nutrient status of individuals. It reviews topics related to water, macroelements, and exercise.Trade Review"This text is perhaps the most comprehensive publication available on macrominerals and sports nutrition."-Mark Kern, Ph.D., R.D., Assistant Professor, Department of Exercise and Nutritional Sciences, San Diego State University, California"Dietitians interested in the specific biochemical, physiological aspects of the body, and nutrition will find this a good tool for understanding the connection between sport activities and nutritional status…provide convincing evidence for their conclusions and offer enough data to assist the sports nutritionist in the development of recommendations for the athlete regarding electrolytes and macroelements most likely to contribute to performance enhancement."--Mary Anne Clairmont, R.D., Today's Dietitian"…an excellent source of information especially for athletes and researchers who have questions concerning proper nutrition for performance…is designed to help everyone understand how specific macro elements, water, and certain electrolytes are important for cellular processes and sports performance…is well written and not only will help athletes but can stimulate further research in this area."-A.H. Goldfarb, CHOICE, January 2000Table of ContentsIntroduction: Macroelements, Water, and Electrolytes in Sports NutritionMacroelementsCalcium in Exercise and Sport - F. BronnerPhosphorus in Exercise and Sport - R.B. KreiderMagnesium in Exercise and Sport - L.R. Brilla and V. P. LombardiWater and Electrolytes Water in Exercise and Sport - P.N. Taylor, I. Wolinsky, and D.J. KlimisSodium in Exercise and Sport - E.R. Buskirk and W.B. FarquharChloride in Exercise and Sports - C.R. Roman-Shriver and L. M. BoylanPotassium in Exercise and Sport - L.C. SenayFluid and Electrolyte Replacement - C. Minson and J.R. HalliwillSupplements Containing MacroelementsMagnesium, Phosphate, and Calcium Supplements - H. LukaskiSports Beverages - J.H. Burns and J.R. BerningSummary - Macroelements, Water , and Electrolytes in Sports Nutrition - J. Driskell and I. WolinskyIndex
£166.25
Taylor & Francis Inc Manual of Immunological Methods Handbooks in
Book SynopsisThe Manual of Immunological Methods represents the collaboration of the Canadian Network of Toxicology Centers, a non-profit network of university-based scientists dedicated to research, training, risk assessment, and communication. This manual provides detailed immunological methods that can be utilized by researchers or practitioners who want to enhance the successful application of this science. It emphasizes the need for continuously improving the quality of experiments performed and maintaining consistency in the results obtained.The Manual of Immunological Methods presents validated assays that are accompanied by a series of tools that will guide readers in performing their own laboratory work in the spirit of the Good Laboratory Practices. It covers specific methodologies including sample collection, preparation of cells, assay conditions, and data evaluation. Discussion of species differences and comparisons of a wide variety of species is an important feature. Both graduatTable of ContentsIdentification, Anaesthesia, and Euthanasia. Collection of Peripheral Blood Samples. Removal of Organs. Preparation of Cell Suspensions. Assessment of Cell Viability. Cell Cryopreservation. Oxidative Burst Assay Using Flow Cytometry. Cell Cytotoxicity. Lymphoblastic Transformation. Determination of Antibody-Producing Cells to a Specific Antigen. Mixed Lymphocyte Reaction (MLR). Intracellular Levels of Calcium Assay Using Flow Cytometry. Phenotyping of Blood Mononuclear Cells. Evaluation of Intracellular Level of Thiols. Apoptosis.OTIsAtlas of Immunology, Julius M. Cruse and Robert E. Lewis, University of Mississippi Medical Center, Jackson, Catalog no. 9489, January 1998, c. 350 pp., 7x10, ISBN: 0-8493-489-9, $69.95Illustrated Dictionary of Immunology, Julius M. Cruse and Robert E. Lewis, Jr., University of Mississippi, Jackson, Catalog no. 4557, 1995, 352 pp., 8.5x11, ISBN: 0-8493-4557-X, $75.00Handbook of Human Immunology, Mary S. Leffell, Noel R. Rose, and Albert D. Donnenberg, Catalog no. 134, April 1997, 656 pp., 6x9, ISBN: 0-8493-0134-3, $99.95
£78.84
Taylor & Francis Inc Neurobiology of Huntingtons Disease
Book SynopsisIn 1993, the genetic mutation responsible for Huntingtonâs disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntingtonâs Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntingtonâs disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation ofTrade ReviewThe book is written lucidly by authorities in their respective fields, covering clinical features, pathogenic mechanisms, protein interactions, preclinical models, biomarkers, small molecules and other approaches (eg, recombinant antibodies), screening strategies, and drug development. Informative figures and tables are provided, and reproduction of key figures as a set of colour plates provides a useful centrepiece. One unifying message is that the polyglutamine xpansion leads to a complex cascade of diverse molecular and cellular events, the progress of which is difficult to slow or halt. Innovative approaches described, such as the target validation process of the Cure Huntington's Disease Initiative (CHDI) Foundation, will be of interest to those studying other neurological diseases.--Anthony J Hannan, writing in The Lancet Neurology, March 2011Table of ContentsIntroduction. Clinical Overview of HD. Genetics of HD. Molecular Pathology of Hungtingtin Function. Genomic, Protemoics, and Metabonomics of HD. High-throughput Screening in HD. High-content Screening in HD. Animal Models for HD. Pharmaceutical Development for HD. HD Clinical Trials.
£185.25
Legend Press Ltd A Silent Gene Theory Of Evolution
Book Synopsis
£14.39
