Biology, life sciences Books

Book SynopsisContinuing a long tradition, Luâs Basic Toxicology, Seventh Edition, combines relatively comprehensive coverage of toxic substances in food, air, and water with brevity, thereby continuing to serve as an updated introductory text for toxicology students and for those involved in allied sciences that require a background in toxicology. The new edition, which now becomes an edited work with contributions from experts around the globe, features four new chapters and a number of existing chapters that have been updated and expanded, notably those on mechanisms of toxic effects, conventional toxicity studies, the cardiovascular system, and risk assessment and regulatory toxicology. The book consists of four parts (Part IâPart IV) that provide guidance on principles of toxicology and testing procedures for toxicities as well as a concise, yet detailed, mechanism of both target organ and nontarget organ toxicities. The book is rounded off with a final sectionTable of ContentsPART I: General Principles of Toxicology. History of Toxicology. Absorption, Distribution, and Excretion of Toxicants. Metabolism of Toxicants. Toxic Effects (Mechanisms of Toxic Effects). Modifying Factors of Toxic Effects. Conventional Toxicity Studies. Systems Toxicology. PART II: Testing Procedures for Nontarget Organ Toxicities. Carcinogenesis. Mutagenesis. Developmental Toxicology. Lactation. PART III: Target Organs and Systems. Toxicology of the Liver. Toxicology of the Kidney. Toxicology of the Immune System. Respiratory System Inhalation Toxicology. Toxicology of the Skin. Toxicology of the Eye. Toxicology of the Nervous System. Cardiovascular System. Toxicology of Reproductive Systems. Toxicology of the Endocrine System. PART IV: Toxic Substances and Risk Assessment. Food Additives and Contaminants. Toxicity of Pesticides. Nanotoxicology. Toxicity of Metals. Environmental Pollutants. Occupational Toxicology. Chemicals and Children. Clinical Toxicology. Risk Assessment and Regulatory Toxicology.

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Book SynopsisThis book is a detailed and comprehensive synthesis of the scientific study of aging. Dozens of contributions from leading scholars review various theories of aging, and molecular, cellular, biochemical and microbial aspects of aging, among just a few of the topics included. Authoritative, wide ranging and thorough, this book will act as a source for experimental design, a comprehensive description of age related diseases, and provide information of the latest molecular theories underlying their causes. Additionally, it will target industries involved in developing anti-aging drugs, post-graduate medical students, and university libraries.Table of ContentsWhat is aging. Biological theories of aging. Free radical theory. Mitochondrial dysfunction theory. Error catastrophe theory. Evolutionary theory of aging. Fading electricity theory. Quasi-program theory for aging. Multiple hormone deficiency theory of aging. Oxidation–inflammation theory of aging. Reproductive-cell cycle theory of aging. Telomeres and telomerase theory of aging. Markov Models of aging. Immunological theory of aging. Social theory of aging. Genetic program theory of aging. Psychological theory of aging. Healthy living and its effects on aging. Longevity in aging. Impact of climate on aging. Centenarians in Okinawa. Genetics of the population. Caloric restriction, healthy diet. Staying young at heart. Genetics of aging and longevity. Metabolic programming, exercise, caloric restriction and aging. Premature aging. Progeria and Werner’s syndrome. Stem cell aging in progeria. Oxidative and nitrosative stress and accelerative aging. Progeria: Genetics, and lamin disorder. Molecular aspect of aging. Hematopoietic stem cells aging. Immune system and aging. Sirtuins in aging and age related diseases. AMPK function in aging. Aging mechanisms and lipid changes. Biochemical aspects of aging. GABA(A) receptors in aging. The ubiquitin-proteasome system and aging. Autophagy and aging. Oxidation of potassium channels and aging. Proteins and lipids in aging. Spatial protein quality control and aging. Klotho protein and aging. Glutathione as antioxidant. Neuropeptide Y as an anti-aging agent. Adipokines and aging. Lamins and aging. Sestrins and aging. HDL metabolism and aging. Growth hormone and aging. DNA damage, repair and aging. DNA damage, repair and neurodegenerative diseases. yH2AX molecular marker for DNA damage and aging. DNA repair in organelles and aging. Transcriptional blocking and DNA damage in aging. Microbiota and aging. Neuroscience of aging. Thermal stress in human and aging. Age related diseases. Ischemic heart disease and aging. Endothelial and vascular aging. The aging heart. Age related eye disease. Age related inflammation and osteoarthritis. Aging and musculoskeletal health. Cancer and aging. Sexual health in aging. Sleep disturbance in aging. Anxiety in aging. Female sexuality and aging. Aging and circadian rhythm. Metabolic syndrome and aging. Environmental toxicants and aging. Stem cell and aging. Non-human models for aging studies. Aging modulation in multiple species. Mouse models. Murine genetic models. C. elegans model. S. cerevisiae model. Drosophila model. Pig model. Mammalian hibernation and aging. Neobiosis as a predecessor of mammalian hibernation. Chemosensory and chemosensory systems and aging. Molecular biology of freezing tolerance. Freezing susceptibility in arthropods. Proteomic approach to study mechanisms of aging. Therapeutic approach for facial aging. Integrative medicine research on aging population. Meditation and aging. Life after death: Fact or fiction.

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Book SynopsisPhylonyms is an implementation of PhyloCode, which is a set of principles, rules, and recommendations governing phylogenetic nomenclature. Nearly 300 clades - lineages of organisms - are defined by reference to hypotheses of phylogenetic history rather than by taxonomic ranks and types. This volume will document the Real World uses of PhyloCode and will govern and apply to the names of clades, while species names will still be governed by traditional codes.Key Features Provides clear regulations for implementing new guidelines for naming lineages of organisms incorporates expressly evolutionary and phylogenetic principles Works with existing codes of nomenclature Eliminates the reliance on rank-based classification in favor of phylogenetic relationships Related Titles:Laurin, M. The Advent of PhyloCode: The Continuing Evolution of Biological Nomenclature (ISBTable of ContentsA-Z list of cladesSECTION 1 1.Pan-Biota 2.Biota 3.Eukarya 4.Metamonada 5.Discoba 6.Discicristata 7.Euglenozoa 8.Sar 9.Stramenopila 10.Rhizaria 11.Foraminifera 12.Alveolata 13.Ciliophora 14.Postciliodesmatophora 15.Intramacronucleata 16.Amorphea 17.Opisthokonta 18.Fungi 19.Dikarya 20.Basidiomycota 21.Ascomycota Metazoa SECTION 2 22.Archaeplastida 23.Rhodoplantae 24.Cyanidiales 25.Rhodophyta 26.Proteorhodophytina 27.Compsopogonophyceae 28.Porphyridiophyceae 29.Rhodellophyceae 30.Stylonematales 31.Eurhodophytina 32.Bangiales 33.Florideophyceae 34.Hildenbrandiales 35.Nemaliophycidae 36.Corallinophycidae 37.Ahnfeltiophycidae 38.Rhodymeniophycidae 39.Viridiplantae 40.Chlorophyta 41.Charophyta 42.Klebsormidiophyceae 43.Phragmoplastophyta 44.Zygnematophyceae 45.Coleochaetophyceae46.Charophyceae Embryophyta SECTION 3 47.Embryophyta 48.Hepaticae 49.Musci 50.Anthocerotae 51.Pan-Tracheophyta 52.Apo-Tracheophyta 53.Tracheophyta 54.Pan-Lycopodiophyta 55.Lycopodiophyta 56.Pan-Euphyllophyta 57.Euphyllophyta 58.Monilophyta 59.Pan-Spermatophyta 60.Apo-Spermatophyta 61.Spermatophyta 62.Pan-Gnetophyta 63.Gnetophyta 64.Pan-Coniferae 65.Coniferae 66.Cupressophyta 67.Pan-Angiospermae Angiospermae SECTION 4 68.Angiospermae 69.Mesangiospermae 70.Magnoliidae 71.Monocotyledoneae 72.Petrosaviidae 73.Commelinidae 74.Poineae 75.Tricolpatae 76.Eudicotyledoneae 77.Gunneridae 78.Pentapetalae 79.Superrosidae 80.Rosidae 81.Malvidae 82.Myrtales 83.Fabidae 84.Leguminosae 85.Superasteridae 86.Caryophyllales 87.Asteridae 88.Ericales 89.Ericaceae 90.Gentianidae 91.Campanulidae 92.Apiidae 93.Campanulaceae 94.Campanuloideae 95.Lobelioideae 96.Lamiidae 97.Lamianae 98.Gentianales 99.Rubiaceae 100.Solanales 101.Solanaceae 102.Convolvulaceae 103.Lamiales 104.Bignoniaceae 105.Orobanchaceae 106.Labiatae107.Nepetoideae SECTION 5 108.Metazoa 109.Porifera 110.Demospongiae 111.Hexactinellida 112.Homoscleromorpha 113.Calcispongia 114.Cnidaria 115.Anthozoa 116.Hexacorralia 117.Octocorallia 118.Medusozoa 119.Cubozoa 120.Hydrozoa 121.Trachylina 122.Hydroidolina 123.Siphonophora 124.Bilateria 125.Protostomia 126.Lophotrochozoa 127.Annelida 128.Rhabdocoela 129.Dalytyphloplanida 130.Kalyptorhynchia 131.Schizorhynchia 132.Pan-Brachiopoda 133.Brachiopoda 134.Pan-Neoarticulata 135.Neoarticulata 136.Cephalopoda 137.Nautilus 138.Neocoleoidea 139.Decapodiformes 140.Vampyroteuthis 141.Octopoda 142.Ecdysozoa 143.Nematomorpha 144.Pan-Nematoda 145.Nematoda 146.Branchiopoda 147.Insecta 148.Trichoptera 149.Polycarpidea 150.Prochaelata 151.Araneae 152.Mesothelae 153.Opisthothelae 154.Mygalomorphae 155.Araneomorphae 156.Orbicularae 157.Deuterostomia 158.Ambulacraria 159.Hemichordata 160.Enteropneusta 161.Pterobranchia 162.Pan-Echinodermata 163.Echinodermata 164.Edrioasterida† 165.Isorophida† 166.Isorophina† 167.Agelacrinitidae† 168.Lepidodiscina† 169.Discocystinae† 170.Chordata 171.Cephalochordata 172.Tunicata SECTION 6 173.Pan-Gnathostomata 174.Apo-Gnathostomata 175.Gnathostomata 176.Pan-Osteichthyes 177.Osteichthyes 178.Pan-Actinopterygii 179.Actinopterygii 180.Pan-Actinopteri 181.Actinopteri 182.Pan-Neopterygii 183.Neopterygii 184.Pan-Teleostei 185.Teleostei 186.Ostariophysi 187.Otophysi 188.Pan-Siluriformes 189.Siluriformes 190.Stegocephali 191.Labyrinthodontia 192.Anthracosauria† 193.Seymouriamorpha† 194.Tetrapoda 195.Amphibia 196.Lissamphibia 197.Gymnophiona 198.Caudata 199.Pan-Amniota 200.Amniota SECTION 7 201.Pan-Mammalia1 202.Synapsida1 203.Therapsida 204.Cynodontia 205.Mammaliamorpha 206.Mammaliaformes 207.Mammalia 208.Pan-Monotremata 209.Monotremata 210.Pan-Xenarthra 211.Xenarthra 213.Scandentia 214.Pan-Primates 215.Primates 216.Apo-Chiroptera 217.Chiroptera 218.Yinpterochiroptera 219.Yangochiroptera 220.Ungulata 221.Artiodactyla 222.Pan-Cetacea 223.Cetacea 224.Pan-Bovidae 225.Cavicornia 226.Bovidae 227.Bovinae 228.Antilopinae 229.Pan-Carnivora 230.Carnivora 231.Pan-Feliformia 232.Feliformia 233.Pan-Caniformia 234.Caniformia 235.Pan-Arctoidea 236.Arctoidea 237.Pan-Pinnipedia 238.Pinnipedia SECTION 8 239.Reptilia 240.Diapsida 241.Pan-Testudines 242.Testudinata 243.Testudines 244.Pan-Pleurodira 245.Pleurodira 246.Pan-Cryptodira 247.Cryptodira 248.Sauria 249.Pan-Lepidosauria 250.Lepidosauria 251.Pan-Squamata 252.Squamata 253.Mosasauridae† 254.Pan-Gekkota 255.Gekkota 256.Pan-Amphisbaenia 257.Amphisbaenia 258.Pan-Serpentes 259.Serpentes 260.Pan-Iguania 261.Iguania 262.Pan-Iguanidae 263.Iguanidae 264.Pan-Acrodonta 265.Acrodonta 266.Pan-Archosauria 267.Archosauromorpha 268.Archosauriformes 269.Archosauria 270.Pterosauromorpha† 271.Pterosauria† 272.Pterodactyloidea† 273.Dinosauria 274.Saurischia 275.Sauropodomorpha† 276.Theropoda 277.Aves 278.Galloanserae 279.Cuculidae 280.Mirandornithes 281.Charadriiformes 282.Procellariiformes 283.Strigiformes 284.Picidae 285.Psittaciformes 286.Daedalornithes 287.Apodiformes

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Book SynopsisStem Cell Research takes a multi-disciplinary approach to the topic of human embryonic stem cell research, starting with the breakthrough discovery up through the present day controversy. The book invites the reader to join the conversation by providing a well balanced approach to many of the issues surrounding the development of this controversial scientific field. It includes the thoughts and experiences of scientists, journalists and ethicists as it tried to approach the topic through a variety of different academic disciplines.The book will help the non-scientist understand the biology, research regulations and funding; and simultaneously it will help the scientist better comprehend the full spectrum of ethical, religious, and policy debates.Table of ContentsStem Cells and the Research Controversy. The Biology of Stem Cells. The Role of the Media. Regulation of the Research: Who Cares or Should Care. Who Pays for the Research: Public and Private Funding. The ethics of Stem Cell Research. Conclusion.

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Book SynopsisAbout our authors Gerard J. Tortora (Chapters 1-5 and 14-16) is professor of biology and former biology coordinator at Bergen Community College in Paramus, New Jersey. He received his bachelor's degree in biology from Fairleigh Dickinson University and his master's degree in science education from Montclair State College. He has been a member of many professional organizations, including the American Society of Microbiology (ASM), the Human Anatomy and Physiology Society (HAPS), the American Association for the Advancement of Science (AAAS), the National Education Association (NEA), and the Metropolitan Association of College and University Biologists (MACUB). Above all, Jerry is devoted to his students and their aspirations. In recognition of this commitment, MACUB presented Jerry with the organization's 1992 President's Memorial Award. In 1995, he was selected as one of the finest faculty scholars of Bergen Community College and was named Distinguished Faculty Scholar. In 1996, he received a National Institute for Staff and Organizational Development (NISOD) excellence award from the University of Texas and was selected to represent Bergen Community College in a campaign to increase awareness of the contributions of community colleges to higher education. Jerry is the author of several best-selling science textbooks and laboratory manuals, a calling that often requires an additional 40 hours per week beyond his full-time teaching responsibilities. Nevertheless, he still makes time for four or five weekly aerobic workouts. He also enjoys attending opera performances at the Metropolitan Opera House, Broadway plays, and concerts. He spends his quiet time at his beach home on the New Jersey Shore. To all my children, the most important gift I have: Lynne, Gerard Jr., Kenneth, Anthony, and Drew, whose love and support have been such an important part of my personal life and professional career. Christine L. Case (Chapters 6-13 and 20-28) taught microbiology at Skyline College in San Bruno, California for 51 years. She received her Ed.D. in curriculum and instruction from Nova Southeastern University and her M.A. in microbiology from San Francisco State University. She was Director for the Society for Industrial Microbiology and is an active member of the ASM. She received the ASM and California Hayward outstanding educator awards. Chris received the SACNAS Distinguished Community College Mentor Award for her commitment to her students, several of whom have presented at undergraduate research conferences and won awards. Chris contributes regularly to the professional literature, develops innovative educational methodologies, and maintains a personal and professional commitment to conservation and the importance of science in society. Chris is also an avid photographer, and many of her photographs appear in this book. I owe my deepest gratitude to Don Biederman and our three children, Daniel, Jonathan, and Andrea, for their unconditional love and unwavering support. Warner B. Bair III (In-the-Clinic videos, eText Media Integration, eText assessments, Dynamic Study Modules) is a professor of biology at Lone Star CollegeCyFair in Cypress, Texas. He has a bachelor of science in general biology and a Ph.D. in cancer biology, both from the University of Arizona. He has over 10 years of higher education teaching experience, teaching both general biology and microbiology classes. Warner is the recipient of multiple educational awards, including the National Institute for Staff and Organizational Development (NISOD) excellence award from the University of Texas and the League for Innovation in the Community College John and Suanne Roueche Excellence Award. Warner has previously authored Interactive Microbiology videos and activities for the Mastering Microbiology website and is a member of the American Society for Microbiology (ASM). He is also a certified Instructional Skill Workshop (ISW) facilitator, where he assists other professors in the development of engaging and active classroom instruction. When not working, Warner enjoys outdoor activities and travel. Warner would like to thank his wife, Meaghan, and daughter, Aisling, for their support and understanding of the many late nights and long weekends he spends pursuing his writing. Derek Weber (In-the-Clinic videos, eText Media Integration, eText assessments, Dynamic Study Modules) is a professor of biology and microbiology at Raritan Valley Community College in Somerville, New Jersey. He received his B.S. in chemistry from Moravian College and his Ph.D. in biomolecular chemistry from the University of WisconsinMadison. His current scholarly work focuses on the use of instructional technology in a flipped classroom to create a more active and engaging learning environment. Derek has received multiple awards for these efforts, including the Award for Innovative Excellence in Teaching, Learning and Technology at the International Teaching and Learning Conference. As part of his commitment to foster learning communities, Derek shares his work at state and national conferences and is a regular attendee at the annual American Society for Microbiology Conference for Undergraduate Educators (ASMCUE). He has previously authored MicroBooster Video Tutorials, available in MasteringMicrobiology, which remediate students on basic concepts in biology and chemistry as they apply to microbiology. Derek is grateful to his wife Lara and his children Andrew, James, and Lilly for their unconditional love and support. Berdell R. Funke (1926-2020) received his Ph.D., M.S., and B.S. in microbiology from Kansas State University. He spent his professional years as a professor of microbiology at North Dakota State University. He taught introductory microbiology, including laboratory sections, general microbiology, food microbiology, soil microbiology, clinical parasitology, and pathogenic microbiology. As a research scientist in the Experiment Station at North Dakota State, he published numerous papers in soil microbiology and food microbiology. In December 2019 Bert received an honorary doctorate from NDSU. The Bison statue he was given at the awards ceremony was a source of great pride for him. His name will live on at NDSU through the Berdell Funke Microbiology Scholarship and the Dr. Berdell Funke Medal of Excellence in Microbiology, which is presented each year to an outstanding graduate. We thank Bert and his family for his contributions over the past thirty years to the first edition of Microbiology, An Introduction, and its subsequent editions.

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Book SynopsisTable of Contents Chapter 1 Basic Concepts Chapter 2. Atoms, Periodicity and Chemical Bonding Chapter 3. An Introduction to the Chemistry of Carbon Chapter 4 Energetics Chapter 5 Equilibria: How far does a reaction go? Chapter 6 Aqueous Equilibria Chapter 7 Biomolecules and biopolymers Chapter 8 Reaction mechanisms Chapter 9. Chemical kinetics Chapter 10 Bioenergetics and Bioelectrochemistry Chapter 11 The role of elements other than carbon Chapter 12 Metabolism Chapter 13 Structural Methods Appendix 1 Basic Mathematical Tools for Biological Chemistry Appendix 2 Answers to end of chapter questions Appendix 3 Periodic Table of the Elements

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Book SynopsisThe latest tools for investigating stress response in organisms, genomic technologies provide great insight into how different organisms respond to environmental conditions. However, their usefulness needs to be tested, verified, and codified. Genomic Approaches for Cross-Species Extrapolation in Toxicology provides a balanced discussion drawn from the experience of thirty-five scientists and professionals from diverse fields including environmental toxicology and chemistry, biomedical toxicology, molecular biology, genetics, physiology, bioinformatics, computer science, and statistics. The book introduces genomic, transcriptomic, proteomic, and metabolomic technologies. It describes the advantages and challenges associated with these approaches compared to traditional methodologies, particularly from the perspective of cross-species extrapolation within human and environmental toxicology, and explores solutions that will facilitate the incorporation of these technologies into Table of Contents"Omic" Approaches in the Context of Environmental Toxicology. Selection of Surrogate Animal Species for Comparative Toxicogenomics. Species Differences in Response to Toxic Substances: Shared Pathways of Toxicity. Bioinformatic Approaches and Computational Models for Data Integration and Cross-Species Extrapolation in the Post-Genomic Era. The Extension of Molecular and Computational Information to Risk Assessment and Regulatory Decision-Making.

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Book SynopsisThe recognition of oxidative stress as a major factor in health, aging, and disease has led to a surge in research aimed at uncovering effective countermeasures in the form of antioxidants. Unique in its two-fold protective function, alpha-lipoic acid has drawn unprecedented interest as a coenzyme in mitochondrial energy metabolism and as an antioxidant and cell redox modulator. Mounting data regarding its potential health benefits demands an authoritative, single-source reference to codify current knowledge and guide future research. A state-of-the-science compilation, Lipoic Acid follows the history of this potent coenzyme and the latest discoveries regarding the chemistry, biological action, and significance in energy production, antioxidant activity, and health. The book is divided into three sections:          Section I: Discovery and Molecular Structure reviews the early studies leading to the discovery of alpha-lipoic Table of ContentsDiscovery molecular structure,A Trail of Research on Lipoic Acid, Lipoic Acid Biosynthesis, The Search for Potent α-lipoic Acid Derivatives: Chemical and Pharmacological Aspects, Novel Indole Lipoic Acid Derivatives: Synthesis and their Antioxidant Effects, Metabolic aspects, The α-keto Acid Dehydrogenase Complexes and Glycine Cleavage System: Their Involvement in Pathways of Carbohydrate, Protein, and Fat Metabolism, Pyruvate Dehydrogenase Complex Regulation and Lipoic Acid, Role of Lipoyl Domains in the Function and Regulation of the Mammalian Pyruvate Dehydrogenase Complex, Inactivation and Inhibition of α-ketoglutarate Dehydrogenase: Oxidative Modulation of Lipoic Acid, Lipoate-Protein Ligase A: Structure and Function, A Review of the Stability & Preliminary Evaluation of the Plasma Pharmacokinetics of R-lipoic acid & R-Dihydrolipoic Acid Dosage Forms in Human Plasma from Healthy Volunteers, The Pharmacokinetics, Metabolism and Renal Excretion of α-lipoic Acid and its Main Metabolites in Humans, Modulation of Cellular Redox and Metabolic Status by Lipoic Acid, The “Redoxin” Connection of Lipoic Acid, Lipoic Acid as an Inducer of Phase II Detoxification Enzymes through Activation of Nrf2-dependent Gene Expression, Clinical aspects, Deficiency Disorders of Components of the PDH Complex: E2, BP & E3 Deficiencies, The Relationship between Primary Biliary Cirrhosis and Lipoic Acid, Effects of Lipoic Acid on Insulin Action in Animal Models of Insulin Resistance, Activation of Cytoprotective Signaling Pathways by Alpha-Lipoic Acid, Selenotrisulfide Derivatives of Alpha Lipoic Acid: Potential Use as a Novel Topical Antioxidant, Alpha-Lipoic Acid: A Potent Mitochondrial Nutrient for Improving Memory Deficit, Oxidative Stress, and Mitochondrial Dysfunction, Effects of Alpha-Lipoic Acid on AMP-Activated Kinase in Different Tissues: Therapeutic Implications for the Metabolic Syndrome

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Book SynopsisComputerized Tomography for Scientists and Engineers is a collection of state-of-the-art articles on computerized tomography (CT). Each article covers a broadband spectrum of CT applications that are related to non-destructive testing (NDT), measurements of solid objects and non-invasive measurements (NIM) in fluids/gases/plasmas. The book addresses essential topics such as: þNon-destructive testing of solid cross-sections þNon-invasive measurements in fluid/gas flows/plasmasþClassical techniques vs. tomographic techniques þGamma-ray, X-ray, laser, and ultrasonic tomographyþData collection techniques þTomographic inversion methods þError analysis of CT images þMeasurement of density/temperature/time-of-light þApplication of CT in multi-phase flows þTomographic extension of classical NDT methods Computerized Tomography for Scientists and Engineers is a thorough, essential reference that provides an excellent account of the present Table of ContentsProcess Tomography: Development and Application of Non-intrusive Measuring Techniques for Multiphase Flows. Impedance Techniques for the Measurement of Two Phase Flow Parameters: Possibilities and Challenges. X-Ray Computed Tomography for Solid Objects. Steady-State Multi-Phase Flow Measurement Facility at FCRI. Bone Imaging Using Compound Ultrasonic Tomography. Challenges in Quantitative Ultrasound Bone Strength Assessment: Status and Perspectives. Computerized Tomography in Blast Furnace. Electrical Process Tomography: Imaging Fluid Mixing Processes Inside Stirred Vessels. Convection in Differently Heated Fluid Layers and Its Reconstruction Using Radial Tomography in an Octagonal Cavity. Tomography in Fusion Plasma Research. Tomographic Reconstructive Techniques for Void Fraction Distribution in Heavy Density Liquid Metal Two-phase Flows. Imaging Buoyancy-Driven Convective Field Around a KDP Crystal Using Schlieren Tomography.

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Book SynopsisUses Computational Tools to Simulate Endocrine Disruption PhenomenaEndocrine Disruption Modeling provides a practical overview of the current approaches for modeling endocrine activity and the related potential adverse effects they may induce on environmental and human health. Based on the extensive research of an international panel of contributors from industry, academia, and regulatory agencies, this is the first book devoted to using computer tools to better understand and simulate the multifaceted aspects of endocrine disruption in humans and wildlife. Explores Diverse Modeling Techniques and ApplicationsThis up-to-date resource focuses on xenobiotics that are accidentally released into the environment with the potential to disturb the normal functioning of the endocrine system of invertebrates and vertebrates but also on the specific agro-chemistry design of chemicals that take controlTable of ContentsIn Silico Methods for Modeling Endocrine Disruption. Mechanisms of Endocrine Disruptions, A Tentative Overview. Population Dynamics Modeling: A Tool For Environmental Risk Assessment of Endocrine Disrupting Chemicals. Application of Pharmacokinetic Modeling to Understand the Mechanism of Action of Endocrine Disrupting Chemicals. Comparative Modeling Review of Nuclear Hormone Receptor Superfamily. The FDA’s Endocrine Disruptor Knowledge Base (EDKB): Lessons Learned in QSAR Modeling and Applications. A Structure-Activity Relationship (SAR) Analysis for the Identification of Environmental Estrogens: The Categorical-SAR (cat-SAR) Approach. Kohonen and Counterpropagation Neural Networks Employed for Modeling Endocrine Disruptors. Quantitative Spectrometric Data-Activity Relationships (QSDAR) Models of Endocrine Disruptor Binding Activities. Mechanism-Based Modeling of Estrogen Receptor Binding Affinity: A COREPA Implementation. Molecular Field Analysis Methods for Modeling Endocrine Disruptors. Structure-Activity Modeling of a Diverse Set of Endrogen Receptor Ligands. SAR and QSAR Analyses of Substituted Dibenzoylhydrazines for Their Mode of Action as Ecdysone Agonists. e-Endocrine Disrupting Chemical Databases for Deriving SAR and QSAR Models.

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Book SynopsisAlthough the amount of research on copper amine oxidases has grown rapidly and substantially in the past decade, the field unfortunately suffers from lack of cohesion and significant confusion surrounds aspects as simple as confirmation of enzyme identities. This book describes the structure of the enzymes, the role of copper, and of the unusual cofactor 6-hydroxydopa quinine derived from a posttranslational modification of a tyrosine residue. It also covers the differences of between AOs from bacteria, plants, and mammals. Finally, the text examines the importance of this ubiquitous class of enzymes in physiology and in metabolism of biogenic amines.Table of ContentsHistory. Nomenclature and Potential Functions of Copper Amine Oxidases. Cofactors of Amine Oxidases: Copper Ion and Its Substitution and the 2, 4, 5-Trihydroxylphenylalanine Quinone. Copper Amine Oxidases from Plants. Soluble Copper Amine Oxidases from Mammals. Membrane-Bound Copper Amine Oxidases. Copper Amine Oxidase Genes. Mechanism of TPQ Biogenesis in Prokaryotic Copper Amine Oxidase. Copper Amine Oxidase Crystal Structures. Plasma Amine Oxidases in Various Clinical Conditions and in Apoptosis. Copper Amine Oxidases in Intestine Diseases. Copper Amine Oxidases in Adipose Tissue-Related Disorders. Copper Amine Oxidases in Adhesion Molecules in Renal Pathology and in Alzheimer’s Disease and VAP-1 in Leukocyte Migration. Inhibitors of Copper Amine Oxidases: Past, Present, and Future. Pharmacological Applications of Copper Amine Oxidases. Copper Amine Oxidases as Antioxidant and Cardioprotective Agents. Biotechnological Aspects of Copper Amine Oxidases. Concluding Remarks. References.

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Book SynopsisThoroughly revised and expanded, the third edition of the Encyclopedia of Chromatography is an authoritative source of information for researchers in chemistry, biology, physics, engineering, and materials science. This quick reference and guide to specific chromatographic techniques and theory provides a basic introduction to the science and technology of the method, offering key references dealing with the methodology for analysis of specific chemicals and applications in industry. With a focus on emerging technologies and uses, the text contains tables and figures that cogently illustrate and clarify technical points in the articles. The Third Edition provides a valuable, reader-friendly reference for all those who employ chromatographic methods for analysis of complex mixtures of substances, as well as practitioners across the entire spectrum of science.What's New in the Third Edition:Bioanalysis: Silica- and Polymer-Based Monolithic Columns

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Book SynopsisThis book details chiroptical spectroscopic methods: electronic circular dichroism (ECD), optical rotatory dispersion (ORD), vibrational circular dichroism (VCD), and vibrational Raman optical activity (VROA). For each technique, the text presents experimental methods for measurements and theoretical methods for analyzing the experimental data. It also includes a set of experiments that can be adopted for undergraduate teaching laboratories. Each chapter is written in an easy-to-follow format for novice readers, with necessary theoretical formalism in appendices for advanced readers. Table of ContentsPolarized Light; Chiral Molecules; Interaction of Circularly Polarized Light with Chiral Molecules; Quantum Chemical Formulation of Chiroptical Spectroscopy; Prediction of Chiroptical Spectra; Conformational Analysis; Experimental Methods for Measuring Chiroptical Spectra; Comparison of Experimental and Calculated Spectra; Chiral Aggregation, Equilibria and the Horeau effect; Applications of Chiroptical Spectra

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Book SynopsisHistochemistry and cytochemistry are important fields for studying the inner workings of cells and tissues of the body. While visualization techniques have been in use for many years, new methods of detection developed recently help researchers and practitioners better understand cell activity. Histochemical and Cytochemical Methods of Visualization describes the essential techniques that can be used for histochemical investigations in both light and transmission electron microscopy. The book begins by discussing techniques in light microscopy. It reviews classical methods of visualization, histochemical and histoenzymatic methods, and methods used to visualize cell proliferation and apoptosis. Next, the book examines the cytochemical methods used in electron microscopy with traditional techniques, as well as more specialized methods. The final section provides an overview of image analysis and describes how image processing methods can be used to extract vital Table of ContentsHistological and Histochemical Methods with Light Microscopy. Classical Methods of Visualization. Histochemical Methods. Enzyme Histochemistry Methods. Visualization of Cell Proliferation. Visualization of Apoptosis. High-Speed Tissue Proteomic. Preparation of Products for Histology and Histochemistry. Cytological Methods in Electron Microscopy. General Techniques in Electron Microscopy. Cytochemical Techniques. Ultrastructural Cytoenzymology. The Acetylation Method. Preparation of Products for Electron Microscopy. Image Quantification. Image Quantification in Histology and Cytology. Index.

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Book SynopsisKnown as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering.Biomedical Engineering Fundamentals, the first volume of the handbook, presents material from respected scientists with diverse backgrounds in physiological systems, biomechanics, biomaterials, bioelectric phenomena, and neuroengineering. More than three dozen specific topics are examined, including cardiac biomechanics, the mechanics of blood vessels, cochlear mechanics, biodegradable biomaterials, soft tissue replacements, cellular biomechanics, neural engineering, electrical stimulation for paraplegia, and visual prostheses. The material is presented in a systematic manner and has been updated to reflect the latest applications and research findings.Table of ContentsPhysiologic Systems. Biomechanics. Biomaterials. Bioelectric Phenomena. Neuroengineering.

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Book SynopsisSince the publication of the pioneering first edition of Chemical Genomics and Proteomics more than seven years ago, the area of chemical genomics has rapidly expanded and diversified to numerous novel methods and subdisciplines, such as chemical glycomics and lipidomics. This second edition has been updated to uniquely reflect this interdisciplinary feature as well as the remarkable developments that have occurred. The new edition also covers innovative applications from cell biology to drug discovery to, more recently, clinical diagnostics and medical practice, which utilize the concepts of chemical genomics.The text provides an overview of the strategies and methodologies of chemical genomics, focusing on emerging technologies and recent applications in the areas of combination chemical genetics, toxicogenomics, drug chemical genomics and proteomics, and orthogonal chemical genetics. It describes the development and application of novel analytical methods used in lTrade ReviewPraise for the First Edition"I thoroughly enjoyed this book and have already had to retrieve it from my PhD students who are anxious to read it ...make sure your library has a copy!"—Journal of Chemical Technology and Biotechnology, Vol. 80, Issue 8, August 2005"[This book] is the first book dedicated solely to chemical genomics. It presents the most important research and developments in chemical genomics … The plentiful tables and figures are well-designed and effectively support the content. … highly recommended for academic and special libraries with relevant programs, and for research scientists in the field."—E-StreamsTable of ContentsUtilizing small molecules in chemical genomics: Toward high-throughput approaches. Development and application of novel analytical methods in lipidomics. From chemical genomics to chemical proteomics: The power of microarray technology. Genomic and proteomic biomarkers in the drug R&D process. Quo vadis biomedical sciences in the omics era: Toward computational biology and medicine. Novel chemogenomic approaches to drug design.

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Book SynopsisEven though enormous advancements have been made in identifying evidence-based lifestyle strategies for hypertension prevention and management, little progress has been made in implementing these proven strategies. Nutrition, Lifestyle Factors, and Blood Pressure compiles practical, science-based information for health care providers to provide effective lifestyle interventions for blood pressure care. Divided into three sections, the book features: Evidence-based blood pressure control and relevant considerations for real-life situations Special considerations in blood pressure control and lifestyle modification among children and adolescents, during pregnancy, and among those with diabetes Practical tools that health care providers can put into practice in particular settings An excellent supplement to existing resources, Nutrition, Lifestyle Factors, and Blood Pressure shortensTable of ContentsEvidence Behind Lifestyle Factors and Blood Pressure. Behavioral Strategies and Blood Pressure Control. Special Considerations.

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Book SynopsisSince the completion of the Human Genome Project, food and nutrition sciences have undergone a fundamental molecular transformation. New discoveries in molecular biology, analytical chemistry, and biochemistry have led to the development of new tools that are likely to revolutionize the study of food. OMICS Technologies: Tools for Food Science explores how these tools reveal the fundamental pathways and biochemical processes that drive food and nutrition sciences.In this volume, an international panel of researchers examines the rise of these new technologiesincluding metabolomics, metagenomics, nutrigenomics, transcriptomics, and proteomicsand describes how they translate to food science research and productive technologies. The book explains how these methods can be used to assess the quality attributes of foods and food production systems. It explores the principles that regulate food production, analyzes processing and ethical issues, and documentsTable of ContentsNutrition Science and "Omics" Technologies: Ethical Aspects in Global Health. Array Platform for Food Safety and Quality. Metabolomics and Food Science: Concepts and Serviceability in Plant Foods and Nutrition. Foodomics: A New Omics for a New Food Era. Proteomics in Food Biotechnology. Challenges in Feasible Problem Construction in Nutritional Genomics: An Empirical Study. Genomics and Breeding in Food Crops. Genomics of Fruit Quality and Disorders. Systems Biology Approaches Reveal New Insights into the Molecular Mechanisms Regulating Flesh Fruit Quality. Coffee Genomics. Omics Approaches to Meat Quality Management. Functional Genomics to Improve Meat Quality in Pigs. Meat Science and Proteomics. Wine-Omics: New Platforms for the Improvement of Yeast Strains and Wine Quality. Aspergillus flavus Genetics and Genomics in Solving Mycotoxin Contamination of Food and Feed. Index.

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Book SynopsisThe fractionation of human blood plasma can be considered to be a mature industry, with the basic technology, alcohol fractionation, dating back at least to the 1940s. Many of the products described in the current work have been approved biologics since the 1950s. The information gathered from the development of plasma proteins has proved vital to the development of recombinant therapeutic proteins. Discussing the role of plasma proteins in current biotechnology, Biotechnology of Plasma Proteins describes the protein composition of human plasma, the fractionation of plasma to obtain therapeutic proteins, and the analysis of these products. It delineates the path from plasma products to recombinant products, and highlights products from albumin, intravenous immunoglobins, and coagulation. It offers a comprehensive review of current techniques for the analysis of proteins including electrophoresis, chromatography, spectrophotometry, mass spectrometry, and updates not pubTable of ContentsBlood, Plasma, Cells, and Other Biological Fluids. Plasma Fractionation and Plasma Protein Products. Methods for the Analysis of Plasma and Plasma Protein Fractions. Albumin. Plasma Immunoglobulins. Factor VIII and von Willebrand Factor. Plasma Proteinase Inhibitors. Vitamin K-Dependent Proteins. Miscellaneous Plasma Proteins.

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Book SynopsisExercise and diet are key factors in the etiology and prevention of chronic disease. While most books on chronic disease have a decided clinical approach, Diet, Exercise, and Chronic Disease: The Biological Basis of Prevention brings together the latest cellular- and molecular-based research on the etiology of chronic diseases and the impact of various aspects of diet and exercise on the causal mechanisms. By focusing on cellular biology, details of the integrative nature of the many different underlying factors are revealeddetails that are not evident with the prevailing clinical approach to chronic disease.This book highlights chronic diseases that are major causes of mortality, and which have sufficient molecular evidence for dietary and activity-related components to their etiology. Individual chapters examine the role of diet and exercise in diabetes, atherosclerosis, osteoporosis, cancer, and neurodegenerative disease. They cover aspects such as disease etiologyTable of ContentsIntroduction. Inflammation. Diabetes. Atherosclerosis. Osteoporosis. Cancer. Neurodegenerative Disease. Hunger and Satiety Signaling. Summary and Recommendations. Index.

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Book SynopsisThe Book provides knowledge on the diversity of disease causing microbes including bacteria, viruses, fungi and Protozoans- the major diseases they cause and the environmental factors that influence the occurrence, transmission and spread of microbes along with the epidemiological factors determining the occurrence of disease.

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Book SynopsisBacterial nanocellulose (BNC) is an emerging nanomaterial with unique properties produced by several species of ubiquitous fermentation bacteria, most importantly Gluconacetobacter xylinus, previously known as Acetobacter xylinum. BNC has been used for a variety of commercial applications including textiles, cosmetics, and food products, and it has a high potential for medical applications. Bacterial NanoCellulose: A Sophisticated Multifunctional Material provides the state of the art of scientific knowledge about the mechanism of cellulose production by bacteria along with pointing out challenges in expansion of BNC production in large scale. It provides the latest update on BNC structure and its modification, as well as comprehensive information about current and future applications of BNC. This seminal work covers the basic science, technology, and economic impact of this bulk chemical as well as the companies and patents that are driving the field. ItTable of ContentsBiosynthesis of Bacterial Cellulose. Effect of Cultivation Conditions on the Structure and Morphological Properties of BNC Biomaterials with a Focus on Vascular Grafts. Large-Scale Production of BNC: State and Challenges. Tough Bacterial Nanocellulose Hydrogels Based on the Double-Network Technique. Bacterial Cellulose Surface Modifications. Nematic Ordered Cellulose Templates. Applications and Products—Nata de Coco. Wound Dressings and Cosmetic Materials from Bacterial Nanocellulose. Bacterial Nanocellulose Hydrogels Designed as Bioartificial Medical Implants. Bacterial Nanocellulose Biomaterials with Controlled Architecture for Tissue Engineering Scaffolds and Customizable Implants. Biomimetic Mineralization of Apatite on Bacterial Cellulose. Bacterial Nanocellulose as a Structured Platform for Conductive Biopolymers.

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Book SynopsisTake Control of Your Data and Use Python with ConfidenceRequiring no prior programming experience, Managing Your Biological Data with Python empowers biologists and other life scientists to work with biological data on their own using the Python language. The book teaches them not only how to program but also how to manage their data. It shows how to read data from files in different formats, analyze and manipulate the data, and write the results to a file or computer screen. The first part of the text introduces the Python language and teaches readers how to write their first programs. The second part presents the basic elements of the language, enabling readers to write small programs independently. The third part explains how to create bigger programs using techniques to write well-organized, efficient, and error-free code. The fourth part on data visualization shows how to plot data and draw a figure for an article or slide pTrade Review“… a significant step forward … The book is cleverly designed to cover a wide range of subjects in a pleasant, easy-to-follow sequence of chapters. These have been carefully prepared so that the minimum level of interdependence is kept, making it possible to begin working at virtually any level without falling into intricate cross-references. A beginner will find the first chapters quite welcoming while a person with medium or even high levels of programming experience can easily find a suitable entry point in the middle.The book is written using an entertaining style that pushes the reader into a naturally built engaging experience … the authors have chosen a collection of underlying subject areas that cover a very wide variety of interests, ensuring that mixed audiences are kept engaged. In that sense, the content becomes adaptable to the wide diversity of learners that are found in today's communities of specialised biologists.… also usable as a reference guide, due to the richness of its worked examples that will prove valuable as seeds for code development for programmers at any level. … as a single book to support learning Python for problem solvers in the life sciences, this book is certainly a very smart choice. It is also ready for creative teachers to develop more in the same direction.”—Pedro L. Fernandes, Instituto Gulbenkian de Ciência"Having read Managing Your Biological Data with Python brings back memories of the times I started writing my first lines of code nearly a decade ago. As a beginning structural biologist without any coding experience, this book would have been a welcome companion to quickly get me started on my bioinformatical projects with Python. It is this, often pragmatic, attitude scientists have towards programming that makes Python the language of choice for many. A clear syntax, powerful build-in functions and a lively ecosystem of user contributed modules allow you to do advanced things with only little lines of code. The book introduces you to the basic principles of programming in Python using the many build-in functions. It does so using practical examples that you can start using right away in your day-to-day research.Python’s modular design principles could even be seen in the organization of this book. If you have never written a line of code in your life, the first chapters are indispensable to teach you basic coding principles but if you have some experience, you can safely skip these. I would however, recommend to read the ones introducing the build-in functions. It never hurts to refresh your memory on the many powerful build-ins Python actually has; I certainly forgot about one or two of them. Working your way through the first chapters will help you get comfortable with Python and lay the foundation for writing more advanced programs in the remaining chapters. These chapters introduce some of the powerful community contributed Python modules that make your life as a biologist a whole lot easier. Again, the example code introducing these modules is of high practical value and together with the coding recipes in the ‘cookbook’ chapter they provide a solid blueprint for you to build your own code upon. I’m confident that reading Managing Your Biological Data with Python will quickly allow you to get the most out of your data and start answering those trilling scientific questions you have, and do all of that while having fun. "—Marc van Dijk, Structural biologist, bioinformaticien, and eScience entrepreneur, Bijvoet Center for Biomolecular Research, Utrecht University, The Netherlands"For many biologists faced with computational challenges, Python has become the language of choice, due to its power, elegance, and simplicity. Managing Your Biological Data with Python by Allegra Via et al. teaches Python using biological examples and discusses important Python-driven applications, such as PyMol and Biopython. The book is an excellent resource for any biologist needing relevant programming skills."—Thomas Hamelryck, Associate Professor, Bioinformatics Center, University of Copenhagen, Denmark"Biological data volumes are growing rapidly as high-throughput technologies (e.g., DNA microarrays or DNA/RNA sequencing) improve. Managing and analyzing biological data are becoming more demanding and the application of programming techniques has simply become a standard. Managing Your Biological Data with Python is one of very few user-friendly books for biologists. It is amazing how clearly authors explain the possible applications of Python for data management (parsing data records, filtering and sorting data) and data visualization (also using the Python interface to R). The book also offers the description of modular programming, which is simply excellent! It guides readers from writing simple functions through writing classes to building program pipelines—everything according to Python coding standards and in an easy-to-follow way. This is absolutely the best book to start learning Python. Intermediate Python users can use this book to learn some new tricks that they could implement in their own code. I can highly recommend this book to researchers, students, and their lecturers."—Dr. Barbara Uszczynska, Centre de Regulació Genòmica (CRG), Barcelona, SpainTable of ContentsGetting Started: The Python Shell. Your First Python Program. Data Management: Analyzing a Data Column. Parsing Data Records. Searching Data. Filtering Data. Managing Tabular Data. Sorting Data. Pattern Matching and Text Mining. Modular Programming: Divide a Program into Functions. Managing Complexity with Classes. Debugging. Using External Modules: The Python Interface to R. Building Program Pipelines. Writing Good Programs. Data Visualization: Creating Scientific Diagrams. Creating Molecule Images with PyMOL. Manipulating Images. Biopython: Working with Sequence Data. Retrieving Data from Web Resources. Working with 3D Structure Data. Cookbook. Appendices.

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Book SynopsisWhile the interdisciplinary field of materials science and engineering is relatively new, remarkable developments in materials have emerged for biological and medical applications, from biocompatible polymers in medical devices to the use of carbon nanotubes as drug delivery vehicles. Exploring these materials and applications, Materials in Biology and Medicine presents the background and real-world examples of advanced materials in biomedical engineering, biology, and medicine.With peer-reviewed chapters written by a select group of academic and industry experts, the book focuses on biomaterials and bioinspired materials, functional and responsive materials, controlling biology with materials, and the development of devices and enabling technologies. It fully describes the relevant scientific background and thoroughly discusses the logical sequences of new development and applications.Presenting a consistent scientific treatment of all tTrade Review" … a timely addition to the field … Cutting-edge articles by leading experts review critical areas covering biomaterials and biomimetic materials, materials function and response modification, and medical device development. Each application-oriented chapter provides the relevant scientific and engineering background with extensive references for further study and research. The contributors use multiple examples to provide rich insights into a broad array of biomaterial applications for a target audience consisting of graduate students, materials scientists, research engineers, and academic physicians and surgeons."—Dr. Sunil K. Kesavan, Akebono Inc., Farmington Hills, Michigan, USA"… a timely addition to the field of … Cutting-edge articles by leading experts review critical areas covering biomaterials and biomimetic materials, materials function and response modification, and medical device development. Each application-oriented chapter provides the relevant scientific and engineering background with extensive references for further study and research. The contributors use multiple examples to provide rich insights into a broad array of biomaterial applications for a target audience consisting of graduate students, materials scientists, research engineers, and academic physicians and surgeons." —Dr. Sunil K. Kesavan, Akebono Inc., Farmington Hills, Michigan, USATable of ContentsIntroduction: Materials in Biology and Medicine. Biomaterials. Hydrophilic Polymers for Biomedical Applications. Hydrogels. Polyanhydrides. Functional Biomaterials. Molecularly Imprinted Polymers. Functionalization of Carbon Nanotubes. Animal Cell Culture. Tissue Engineering. Bioactive Devices. Cell Encapsulation. BioMEMS. Immobilized Enzyme Technology. Biocompatibility-Imparting Nanofilm Coating.

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Book SynopsisClinicians undergoing competency testing, certification, and periodic recertification are frequently faced with computer-based exams designed to evaluate clinical acumen and judgment. Test questions often include an image or radiograph followed by a vignette of the clinical encounter and a series of questions. Designed to better prepare practitioners for image-intense, computer-based examinations in their respective fields, Atlas of Human Poisoning and Envenoming is a visual and written reminder of the ubiquitous sources of toxins and toxoids in the environment and the outcomes of accidental or intentional toxic exposures in humans. The Second Edition has been restructured with bulleted text, tables, and figures resembling the vignettes that accompany national examinations. Combining the four specialties of toxicologyanalytical, medical, environmental, and industrialinto one comprehensive atlas, the book presents photographs and diagrams of toxic plants aTrade Review"Compared to other narrative-based references in this exceptionally complicated and detail-driven field, this atlas presents small bites of easily digestible information."—Sean P. Boley, MD, Regions Hospital and Level 1 Trauma Center for Doody's Review ServiceTable of ContentsGeneral Medical Toxicology. The Pharmacology of Human Poisoning and Envenoming. General Poisoning Management. Diagnostic Work-Up of the Poisoned Patient. Poison Antidotes. Toxicity of Antiseptics and Drug Additives. Poisonings with Over-the-Counter and Opioid Analgesics. Household Product Poisonings. Drug and Illicit Substance Abuse. Anticonvulsants and Sedative-Hypnotics. Reproductive and Perinatal Toxicology and Teratogenesis. Hypoglycemic and Other Endocrine Agent Toxicity. Cardiovascular Drug Toxicity. Antibiotic Toxicity. Anticancer Drug Toxicity. Environmental and Occupational Nephrotoxicology. Neurotoxicology. Environmental Toxicology. Food Poisoning. Seafood Poisoning. Mushroom Poisonings. Herbal Poisonings. Common Poisonous Household and Garden Plants. Bites and Stings: Terrestrial Envenomings. Common Arthropod Vectors of Infectious Diseases. Tick Paralysis. Bites and Stings: Marine Envenomings. Voodoo, Hoodoo, and Cajun Traditions and Poisonings. Industrial and Occupational Toxicology. Volatile Organic Chemicals. Petrochemical Toxicity. Industrial Gas Exposures and Occupational Lung Diseases. Metal and Metalloid Poisonings. Pesticide Poisonings: Insecticides, Rodenticides, and Herbicides. Radiation Toxicology. Chemical, Biological, and Radiological Weapons and Warfare. Workplace Substance Abuse Monitoring. Miscellaneous Toxicants. Epidemiology and Statistics for Toxicology. Epidemiology and Statistics for Toxicology. Index.

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Book SynopsisThis book discusses the structure, synthesis, and reactivity of heterocyclic compounds. It covers nomenclature, conformational aspects, aromatic stabilization and biological activity of heterocyclic compounds. The book also includes discussions of biochemical processes involving destruction of heterocyclic rings. It includes problem sets that help readers to understand and apply the principles of heterocyclic reactivity and synthesis. The inclusion of more advanced material and references make the book a valuable reference text for postgraduate taught courses, postgraduate researchers, and chemists at all levels working with heterocyclic compounds in industry, particularly in the pharmaceutical and agrochemical industries. Table of ContentsIntroduction. Nomenclature of Heterocyclic Compounds. Three-Membered Heterocyclic Compounds with One Hetero Atom. Three-Membered Heterocyclic Compounds with Two Hetero Atoms. Four-Membered Heterocyclic Compounds with One Hetero Atom. Four-Membered Heterocyclic Compounds with Two Hetero Atoms. Five-Membered Heterocyclic Compounds with One Hetero Atom. Bicyclic Ring Systems Derived from Pyrrole, Furan and Thiophene. Five-Membered Heterocyclic Compounds with Two Hetero Atoms. Bicyclic Ring Systems Derived from pyrazole, imidazole, oxazole,isoxazole and thiazole. Six-Membered Heterocyclic Compounds with One Hetero Atom. Bicyclic Ring Systems Derived from Pyridine. Tricyclic Ring System Derived from Pyridine. Six-Membered Heterocyclic Compounds with Two Hetero Atoms. Bicyclic Ring Systems Derived from Pyridazine, pyrimidine, pyrazine. Seven-Membered Heterocyclic Compounds.

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Book SynopsisIn computational science, reproducibility requires that researchers make code and data available to others so that the data can be analyzed in a similar manner as in the original publication. Code must be available to be distributed, data must be accessible in a readable format, and a platform must be available for widely distributing the data and code. In addition, both data and code need to be licensed permissively enough so that others can reproduce the work without a substantial legal burden.Implementing Reproducible Research covers many of the elements necessary for conducting and distributing reproducible research. It explains how to accurately reproduce a scientific result. Divided into three parts, the book discusses the tools, practices, and dissemination platforms for ensuring reproducibility in computational science. It describes: Computational tools, such as Sweave, knitr, VisTrails, Sumatra, CDE, and the Declaratron syTrade Review"This collection brings together the expertise and experience of numerous authors and is likely to be valuable to scientists and statisticians alike. … This book should have broad appeal … introduces some extremely useful tools and practices from leaders in the field. On top of that, it also contains an exciting vision for the future of scientific research. … The challenge of reproducibility in the computational era is being confronted across the sciences, with each field developing its own tools and best practices. This book is an important step in bringing together a broad group of scientists to share what has been learned."—Journal of the American Statistical Association, June 2015 "The book as a whole has something for everybody and provides an interesting snapshot of the available tools, platforms, and good practices for researchers as the scientific community aims to be more self-correcting."—Journal of Statistical Software, October 2014 "Three recent books have significantly influenced how I use R in reproducible work: Dynamic Documents with R and knitr by Yihui Xie, Reproducible Research with R and RStudio by Christopher Gandrud, and Implementing Reproducible Research edited by Victoria Stodden, Friedrich Leisch, and Roger D. Peng … I recommend all three books to R users at any level. There really is something here for everyone."—Richard Layton, PhD, PE, Rose-Hulman Institute of Technology, Terre Haute, Indiana, USA "In total, this book provides information on almost all aspects of reproducible research in the open science environment … I would recommend this book to anybody who wants to learn more about reproducible research in the context of open science."—Biometrical Journal Table of ContentsTools: knitr: A Comprehensive Tool for Reproducible Research in R. Reproducibility Using VisTrails. Sumatra: A Toolkit for Reproducible Research. CDE: Automatically Package and Reproduce Computational Experiments. Reproducible Physical Science and the Declaratron. Practices and Guidelines: Developing Open-Source Scientific Practice. Reproducible Bioinformatics Research for Biologists. Reproducible Research for Large-Scale Data Analysis. Practicing Open Science. Reproducibility, Virtual Appliances, and Cloud Computing. The Reproducibility Project: A Model of Large-Scale Collaboration for Empirical Research on Reproducibility—Open Science Collaboration. What Computational Scientists Need to Know about Intellectual Property Law: A Primer. Platforms: Open Science in Machine Learning. RunMyCode.org: A Research-Reproducibility Tool for Computational Sciences. Open Science and the Role of Publishers in Reproducible Research. Index.

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Book SynopsisShallow water marine molluscan faunas are distributed in a pattern of distinct, geographically definable areas. This makes mollusks ideal for studying the distribution of organisms in the marine environment and the processes and patterns that control their evolution. Biogeography and Biodiversity of Western Atlantic Mollusks is the first book to use quantitative methodologies to define marine molluscan biogeographical patterns. It traces the historical development of these patterns for the subtropical and tropical western Atlantic. The book discusses the multistage process of evolving new taxa caused by eustatic fluctuations, ecological stress, and evolutionary selection. Drawing on his decades of intensive field work, the author defines three western Atlantic molluscan provinces and 15 subprovinces based on his Provincial Combined Index, a modern refinement of Valentineâs 50% rule. The faunal provincesâCarolinian, Caribbean, and Brazilianâare discussed in detail. TheTrade Review"Professor Petuch draws upon an extraordinary wealth of personal experience and many decades of field work studying both recent and fossil mollusks throughout the western Atlantic, and has produced a prolific body of publications on these faunas. … [He] is to be commended for clearly and succinctly defining a useful tool for quantifying faunal distinctions among geographic regions. This methodology can also be used to produce a series of testable hypotheses that will serve both as a foundation and as a point of departure for additional research into the effects of geography and ecology on the evolution and diversification of faunas."—From the Foreword by M. G. Harasewych, Ph.D., National Museum of Natural History, Smithsonian InstitutionTable of ContentsIntroduction: American Molluscan Faunas in Time and Space. The Molluscan Provincial Concept in the Tropical Western Atlantic. Provinces of the Tropical Western Atlantic. Molluscan Biodiversity in the Georgian Subprovince. Molluscan Biodiversity in the Subprovinces of the Florida Peninsula. Southern and Western Subprovinces of the Carolinian Province. Northern Subprovinces of the Caribbean Province. Molluscan Biodiversity in the Nicaraguan Subprovince. Molluscan Biodiversity in the Venezuelan Subprovince. Molluscan Biodiversity in the Grenadian and Surinamian Subprovinces. Northern Subprovinces of the Brazilian Province. Molluscan Biodiversity in the Paulinian Subprovince. Bibliography. Appendices. Index.

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Book SynopsisMany varieties of new, complex diseases are constantly being discovered, which leaves scientists with little choice but to embrace innovative methods for controlling the invasion of life-threatening problems. The use of nanotechnology has given scientists an opportunity to create nanomaterials that could help medical professionals in diagnosing and treating problems quickly and effectively. Bioengineered Nanomaterials presents in-depth information on bioengineered nanomaterials currently being developed in leading research laboratories around the world. In particular, the book focuses on nanomaterials for biomedical applications.This collection brings together novel methodologies and strategies adopted in the research and development of bioengineered nanomaterials and technology. Renowned international researchers discuss topics including: Nanoemulsions as a vaccine adjuvant Bioceramic nanomaterials in medical applications NaturaTable of ContentsEmerging Potential of Nanoparticles for the Treatment of Solid Tumors and Metastasis. Aptamer–Nanomaterial Conjugates for Medical Applications. Recent Advances in Immobilization Strategies in Biomaterial Nanotechnology for Biosensors. Nanofibers and Nanoparticles in Biomedical Applications. Nanoemulsions as a Vaccine Adjuvant. Inorganic Nanomaterials of Carbonate Apatite as Intracellular Nucleic Acid/Drug Transporters. Bioceramic Nanomaterials in Medical Applications. Imaging and Triggered Release through Design of Ultrastable Core–Shell Iron Oxide Nanoparticles. Natural and Synthetic Nanoporous Membranes for Cell Encapsulation Therapy. Lipid and Cyclodextrin Nanocarriers Loading Bioactive Agents: Stabilization on Polymeric Supports. Silver Nanoparticles: Nanotoxicity Testing and Bioapplications. Nanoparticle Production for Biomedical Applications via Laser Ablation Synthesis in Solution. Nanomedicine in Brain Tumors. Inorganic Nanoparticle Materials for Controlled Drug Delivery Systems. Gold Nanoshells and Carbon Nanotubes as a Therapeutic Tool for Cancer Diagnosis and Treatment. Bioinspired Nanomaterials for Bone Tissue Engineering. Index.

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