Description
Book SynopsisMetabolism of Brain Peptides discusses neuropeptide metabolism in light of recent research. It describes the processing mechanisms in the production of biologically active peptides. It details distribution of the variety of neuropeptides in the brain and comprehensively reviews the effects of these neuropeptides on behavioral and physiological functions. The book also examines termination mechanisms for the biological activities of neuropeptides in light of recent knowledge of their distribution, their receptors and their possible inactivation enzymes in various functional regions of the brain and at the blood-brain barrier.
Table of ContentsThe Production of Biologically Active Peptides in Brain Tissues, J. Donlon, University College of Galway, Republic of Ireland
Specific Aspects of Peptide Proteins
Peptide Amidation
Biological Activity of Peptides in Brain Tissues, F. Roman, Institut de Recherche Jouveinal, France
Introduction
Neuropeptide Y
Calcitonin-gene Related Peptide
Cholecystokinin
Galanin
Neurotensin
Neuropeptide Receptor-Ion Channel Coupling in the Mammalian Brain, P. Boden, Parke-Davis Neuroscience Research Centre, Cambridge, England
Methodological Approaches
Neuropeptides and Ion Channels: Mechanistic Studies
Inactivation of Thyrotropin Releasing Hormone (TRH). The TRH-Degrading Enzyme as a Regulator and/or Terminator of TRH Signals, K. Bauer, Max-Planck-Institute for Experimental Endocrinology, Hannover, Germany
Characteristics of the TRH-Degrading Serum Enzyme and the membrane-Bound TRH-Degrading Enzyme
Cellular and Subcellular Localization
Purification and Cloning
Hormonal Regulation of the TRH-Degrading Enzymes
Intracellular Peptide Turnover: Properties and Physiological Significance of the Major Peptide Hydrolases of Brain Cystosol, S. Wilk, Mount Sinai School of Medicine, New York, New York
Endopeptidases
Oligopeptidases
Exopeptidases
Omega Peptidases
