Description
Book SynopsisAfter a century of research, several lines of evidence now indicate that the ability of adenosine to directly control inflammatory cells has a major impact on the functions of the inflammatory and immune systems. Consequently, many promising therapeutic approaches are beginning to emerge that focus on the modulation of adenosine, including the development of compounds that interfere with the breakdown of adenosine, as well as specific agonists and antagonists of various adenosine subtypes. Some of these compounds have already entered clinical trials. While information on the role of adenosine is growing rapidly, until now it has remained scattered in the literature.
Edited by three pioneering researchers in the field, Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases presents the first single volume compilation of reviews on how adenosine, acting on its cellular receptors, regulates immune responses. The book is organized to provide the reade
Trade Review
"… written by a number of prime experts in the field. … highly recommended to readers who are interested in the pharmacology of adenosine receptors."
– Christa E. Muller, PharmaCenter Bonn, Germany in ChemMedChem, 3, 2008
Table of ContentsIntroduction. Adenosine Receptor Pharmacology. Regulation of Macrophage Function by Adenosine Receptor Engagement. Anti-inflammatory Effects of Inosine. Regulation of Adenosine Receptor Expression in Inflammation. A2a Adenosine Receptors in Ischemia. Adenosine, Toll-like Receptors, and Angiogenesis. Adenosine Signaling and Lung Fibrosis. Adenosine and Endothelial Cell Function. Regulation of Peripheral Inflammation by Spinal Adenosine. Adenosine, Hypoxia, and Immunity. Adenosine Regulation of Dendritic Cell Function. A2b Receptors in Intestinal Epithelial Cells. Adenosine Receptors in Multiple Sclerosis. Adenosine Receptors in Infectious Disease. Adenosine, Tumors, and Immunity. Adenosine in Atherosclerosis. Adenosine in Neuroimmunomodulation.
