Medical research Books
John Wiley and Sons Ltd Handbook of Service User Involvement in Nursing
Book SynopsisHandbook of User Involvement in Nursing and Healthcare Research is an invaluable guide to those working in nursing and healthcare research, helping them understand service users' expectations about involvement.Trade Review“The book is clearly written with pertinent examples drawn from real life. The index is clear and easy to use.” (Nursing Times, 17 September 2012) Table of ContentsContributors viii About the authors x Preface xii Structure of the book xv Acknowledgements xviii Part I Preparing 1 1 Perspectives and expectations 3 Approaching service user involvement 4 Political and research contexts of involvement 7 Historical roots and social movements 8 Perspectives of service user involvement 12 What is known about the impact of involvement? 14 Current challenges 15 2 Concepts 18 Service users 19 Involvement 21 Representation 22 Experiential knowledge 24 Empowerment 25 Participation 26 Models of involvement 27 A theoretical framework for approaching service user involvement in research 30 3 Designing involvement 36 Deciding who to involve 37 Building in opportunities for involvement 40 Research methods and approaches to involvement 42 Planning involvement 48 Payments 48 Research ethics and governance 54 4 Working relationships 59 Making connections 60 Working environments 61 Roles and responsibilities 66 Legal and ethical issues 67 Training and support 68 Communication 70 Feedback and reflection 72 Embedding service user involvement 72 Part II Learning 77 5 Patients, clients and carers 79 Patients who are receiving health care 80 People who are very sick 83 People with rare clinical conditions 85 People who find it difficult to access services 85 People who do not have the capacity to consent 87 Carers 89 6 Involvement over the life course 93 Children and their parents 93 School-age children 97 Young people 100 Adults 102 Older people 103 7 Seldom-heard groups 106 Involving seldom-heard groups 107 People with physical disabilities 108 The deaf and people who are hard of hearing 110 People who are blind or partially sighted 111 People with learning disabilities 111 People with degenerative cognitive impairment 113 People with mental health problems 113 Black and minority ethnic groups 116 8 Service user-led research 120 Personal health research 121 Volunteer networks 121 Service user-led organisations 123 Charities and not-for-profit organisations 125 Experienced service user representatives 127 Academic service user researchers 128 Part III Evaluating 133 9 Quality 135 Indicators of successful involvement 136 Documenting service user involvement work 137 Using reflective techniques 139 Reflexivity and service user involvement 142 Quality experiences of involvement 143 Quality environments for involvement 146 10 Impact 151 Why we need to know about impact 152 Designing an assessment of impact 153 Recognising impact 154 Recording impact 157 Reporting impact 161 11 International perspectives 165 Europe 166 The USA 168 Canada 169 Australia and New Zealand 170 Developing countries 172 12 Conclusion 176 Summary conclusions 177 Service user involvement enhancing evidence-based practice 178 Enriching professional education 179 Teaching service user involvement in research 180 Developing professional roles 184 Securing service user’s commitment to involvement 185 Further reading 188 Web-based resources 189 Index 191
£37.00
Springer London Ltd An Introduction to Toxicology
Book SynopsisThe Emergence of Modern Toxicology.- Core Concepts in Toxicology.- Toxicokinetics - The Fate of Chemicals within the Body.- Toxicodynamics - How Chemicals Induce Toxicity.- Fightback - Adaptive Responses to Toxicant Exposure.- Target Organ Toxicity: Liver and Kidney.- Chemical Toxicity to the Unborn.-Chemicals and Cancer.-Everyday Toxicology I - Alcohol.-Everyday Toxicology II - Tobacco. ? ? ?Trade ReviewFrom the book reviews:“I found this to be an excellent text book, in fact one of the best I have referred to in recent times. Whether one is a non-toxicologist seeking an overview of the subject or an Industrial Toxicologist working every day to tackle the issues of product development, there is something for everybody. … This book should be a point of reference for any modern toxicologist – it will be for me!” (Jim Ridings, bts News Magazine of The British Toxicology Society, Vol. 1 (2), September, 2014)Table of ContentsThe Emergence of Modern Toxicology.- Core Concepts in Toxicology.- Toxicokinetics - The Fate of Chemicals within the Body.- Toxicodynamics - How Chemicals Induce Toxicity.- Fightback - Adaptive Responses to Toxicant Exposure.- Target Organ Toxicity: Liver and Kidney.- Chemical Toxicity to the Unborn.- Chemicals and Cancer.- Everyday Toxicology I - Alcohol.- Everyday Toxicology II - Tobacco.
£71.24
John Wiley & Sons Human Caring Science A Theory of Nursing
Book Synopsis
£80.10
University of Toronto Press Recent Progress in Microbiology VIII
Book SynopsisThis important volume presents the symposia and panel discussions held at the VIII International Congress for Microbiology, Montreal, 1962. The topics reported on include: Structure and Function ("Membrane Permeation"; "Properties of Isolated Cellular Particles"); Agricultural Microbiology ("Insect Microbiology"; Psychrophilic Microorganisms"; "Enzymes in Soils"; "Effect of Chemical and Biological Control Measures on Soil Micro-organisms"); Industrial Microbiology ("Genetics Applied to Industrial Microbiology"; "Microbial Production of Amino Acids"; "Evolutionary Operation and Horizons in Industrial Microbiology"); Virology ("Mechanisms of Immunity in Infectious Diseases"; "Interference and Interferon"; "Demonstrations of Viruses in Neoplasia"); Medical and Veterinary Microbiology ("Pleuropneumonia-like Organisms as Agents of Human and Animal Diseases"; "The Virulence of Staphylococci"); general subjects ("Microbial Classification"; "Influence of the Environment on the Epidemiology
£49.30
O'Reilly Media Genomics in the Cloud
Book SynopsisData in the genomics field is booming. With this practical book, researchers will learn how to work with genomics algorithms using open source tools including the Genome Analysis Toolkit (GATK), Docker, WDL, and Terra.
£53.99
Cornell University Press Research as Development
Book SynopsisIn Research as Development, Salla Sariola and Bob Simpson show how international collaboration operates in a setting that is typically portrayed as resource-poor and scientifically lagging. Based on their long-term fieldwork in Sri Lanka, Sariola and Simpson bring into clear ethnographic focus the ways international scientific collaborations feature prominently in the pursuit of global health in which research operates as development and not merely for it. The authors follow the design, inception, and practice of two clinical trials: one a global health charity funded trial and the other a pharmaceutical industry-sponsored trial. Research as Development situates these two trials within their historical, political and cultural contexts and thus counters the idea that local actors are merely passive recipients of new technical and scientific rationalities. While social studies of clinical trials are beginning to be an established niche in academic writing, ReseTrade ReviewEthnographic inquiry reveals that international clinical research and collaboration engages many stakeholders at multiple levels of society. The implications of these multilevel research interactions are changes in culture, technological innovation, and expertise that impacts national development, particularly in health and economics. The derived ethnographic conclusions, while important, are not earth-shattering. * Choice *In sum, this is a very inspiring book that incites us to think in novel ways about the crucial theme of ethics in global bio- and inter-medical collaboration. It will be highly relevant to scholars in both social and medical sciences and accessible to students. * Medical Anthropology Quarterly *
£39.60
John Wiley and Sons Ltd Resveratrol and Health: 2nd International
Book SynopsisResveratrol (3,5,4'-trihydroxy-trans-stilbene) is a phenol phytoalexin derived from grapes, berries, and other plants possessing a spectrum of pharmacologic properties. Resveratrol has been shown to modulate LDL levels, a major risk factor for cardiovascular disease, to interfere with or inhibit oncogenesis and tumor proliferation in in vivo animal cancer models and in human tumor cells in vitro, to significantly extend the lifespan of the yeastSaccharomyces cerevisiae, Caenorhabditis elegans and the fruit fly Drosophila melanogaster, and to produce wide-ranging benefits in animal models of obsesity and diabetes.Resveratrol has gained mainstream attention as “the red wine pill,” with widespread claims made of human health benefits that have outpaced the existing evidence. Over the past few years, many clinical trials have been conducted to evaluate the health effects of resveratrol in humans, in the treatment of cancer, cardiovascular disease, obesity, diabetes, osteopenia and osteoporosis, and others. Considerable work is also underway exploring the optimization of resveratrol delivery and bioavailability in nutraceutical and pharmaceutical paradigms. NOTE: Annals volumes are available for sale as individual books or as a journal. For more information on institutional journal subscriptions, please visit: http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.
£99.00
John Wiley and Sons Ltd The Evolution of Human Handedness, Volume 1288
Book SynopsisHandedness, or manual laterality of function, is thought to be both universal and unique to humans, making it a highly derived trait, based on an equally specialized neural substrate. By contrast, in various non-human species, both living and extinct, extent of lateralization varies. All known populations of living human beings apparently favor the right hand, motorically, culturally, and symbolically, thus right-handedness is species-typical, as well as species-specific. This laterality of function is correlated with asymmetry of structure, that is, neural, skeletal and muscular, for example as manifest especially in skilled movement, such as handwriting. Human brains are lop-sided, and sagitally-paired organs (hand, foot, eye, ear, etc.) are skewed in their use, usually biased to the right; explaining this variation appears to require both cultural and environmental causal variables. To tackle these questions and advance our knowledge of this basic human trait requires genuinely multi-disciplinary input by scholars willing to think inter-disciplinarily. Thus, participants in this Annals volume come from anthropology, archaeology, genetics, neurosciences, palaeo-anthropology, primatology, psychology, and psychiatry. NOTE: Annals volumes are available for sale as individual books or as a journal.Table of Contentsv Introduction to The Evolution of Human Handedness William C. McGrew, Wulf Schiefenhövel, and Linda F. Marchant Comparative 1 Handedness is more than laterality: lessons from chimpanzees Linda F. Marchant and William C. McGrew 9 Laterality in the gestural communication of wild chimpanzees Catherine Hobaiter and Richard W. Byrne 17 Neuroanatomical asymmetries and handedness in chimpanzees (Pan troglodytes): a case for continuity in the evolution of hemispheric specialization William D. Hopkins Substrates 36 The protocadherin 11X/Y (PCDH11X/Y) gene pair as determinant of cerebral asymmetry in modern Homo sapiens Thomas H. Priddle and Timothy J. Crow 48 Multilocus genetic models of handedness closely resemble single-locus models in explaining family data and are compatible with genome-wide association studies J.C. McManus, Angus Davison, and John A. L. Armour 59 Laterality and the evolution of the prefronto-cerebellar system in anthropoids Jeroen B. Smaers, James Steele, Charleen R. Case, and Katrin Amunts Human evolution 70 Primate laterality and the biology and evolution of human handedness: a review and synthesis W. Tecumseh Fitch and Stephanie N. Braccini 86 Skeletal evidence for variable patterns of handedness in chimpanzees, human hunter-gatherers, and recent British populations Jay T. Stock, Meghan K. Shirley, Lauren A. Sarringhaus, Tom G. Davies, and Colin N. Shaw 100 The fighting hypothesis in combat: how well does the fighting hypothesis explain human left-handed minorities? Ton G.G. Groothuis, I.C. McManus, Sara M. Schaafsma, and Reint H. Geuze 110 The fighting hypothesis as an evolutionary explanation for the handedness polymorphism in humans: where are we? Charlotte Faurie and Michel Raymond Modern Humans 114 The nature and nurture of human infant hand preference Jacqueline Fagard 124 Laterality of handgrip strength: age- and physical training-related changes in Lithuanian schoolchildren and conscripts Janina Tutkuviene and Wulf Schiefenhövel 135 Biased semantics for right and left in 50 Indo-European and non-Indo-European languages Wulf Schiefenhövel
£99.00
Humana Press Inc. Skeletal Atlas of Child Abuse
Book SynopsisThis illustrated guide to the role of the forensic anthropologist in investigating child abuse is an essential resource in one of the most contentious areas of forensic pathology. Not only does it supply a review of the literature in this field, but it illustrates the material with photographs from real cases investigated by the Harris County Institute of Forensic Sciences, which serves a population of four million people. Broken down into body regions and skeletal elements for ease of reference, the atlas facilitates the vital work performed by forensic anthropologists, who bring to the autopsy table a store of specialist knowledge that can turn a case.Despite the frequency of child fatalities (in America, 2.3per 100,000) attributed to physical abuse, merely recognizing the offense is a major forensic challenge. The tell-tale signatures of non-accidental injury can be very subtle, making it difficult to differentiate between accidental and non-accidental injury. Yet successful adjudication of a child abuse case often rests on the correct interpretation of skeletal injury.In this volume the authors guide the reader through published data regarding the mechanics and interpretation of injuries,including the agencies they indicate. The material includes discussion of the limitations faced in interpreting some injuries, where making a judgment on cause is tricky. In addition, a chapter on natural diseases affecting the bones provides a good overview of several conditions that are often invoked as 'mimics' of child abuse. Finally, this publication evinces the value of collaboration between the pathologist and the anthropologist.Trade ReviewFrom the reviews:“The atlas is a detailed guide to the role of the forensic anthropologist in the investigation of skeletal injuries. … Not only does the book give a good overview of the relevant literature on the topic, it also provides many excellent images of cases, both in situ and after processing. … very informative for both forensic pathologists and forensic anthropologists, especially in regions where the disciplines do not work together in cases of fatal child abuse, which is the case in most European countries.” (Saskia S. Guddat, Forensic Science, Medicine and Pathology, April, 2013)Table of ContentsSkeletal Examination Method.- Skull Fractures.- Rib Fractures.- Fractures of the Vertebral Column, Sternum, Scapulae, and Clavicles.- Long Bone Fractures.- Healing and Interpretation.- Natural Disease May Mimic Child Abuse
£208.99
John Wiley & Sons Inc Research Methods in Communication Disorders
Book SynopsisMany communication disorders are poorly understood and many treatments used in therapy remain unproven. Speech and Language therapists are increasingly involved in research in these areas but may lack the training and experience required to conduct it. Not the least of their problems is that few textbooks discuss the specific problems of research design in communication disorders. Research Methods in Speech and Language Therapy fills this gap. It will serve as an introductory text for students who are training to be therapists and as an introduction to more advanced methods for clinicians involved in research. Different approaches to research are described and the basic principles of research design and statistical analysis described. The book uses a wide range of published research to illustrate how research may be conducted in these areas and gives particular attention to the problems of researching the effectiveness of therapy.Trade Review"...a highly accessible volume...I would urge any therapist, student or researcher in communication disorders to have this text to hand..." (Child Language Teaching & Therapy, Vol 21 (3) 2005)Table of ContentsForeward. Preface. Chapter 1 Introduction. Chapter 2 Designing experiments. Chapter 3 Describing data. Chapter 4 The normal distribution and staandardized tests. Chapter 5 Some statistical tests. Chapter 6 Analysis of variance I. Chapter 7 Analysis of variance II. Chapter 8 Into the storm. Chapter 9 Analysising categorical data. Chapter 10 Correlation and regression. Chapter 11 Measurement. Chapter 12 Asking questions. Chapter 13 Observational research. Chapter 14 Efficacy: are we going about it in the right way? Chapter 15 Single cases and specific therapies. Answers to exercises. Appendices. References. Index.
£41.75
John Wiley & Sons Inc Implementing Research in the Clinical Setting
Book SynopsisThis practical handbook aims to give the practising nurse and health-care professional the tools to implement research in the clinical setting. There is no intention here of revisiting the deep theoretical issues related to research; rather the book seeks to offer a clear toolkit on how the research might be implemented. Chris Bassett has drawn together the work of six acknowledged experts in this field.Trade Review"... this book is very readable..." (Musculoskeletal Care, October 2006)Table of ContentsThe Importance of Research in Nursing Practice. The Relevance of research in Nursing. Commonly-used Research Methods. Reading and Understanding research Reports. Exploring and Overcoming The Barriers to Research. Local and national Context of Research.
£43.65
John Wiley & Sons Inc Physical Assessment of Patients
Book SynopsisAssessment is arguably the most important stage of nursing. It forms the basis for any planned nursing intervention and a baseline against which subsequent events in the hospital stay can be compared. Assessment is an ongoing activity where the patient is continually reviewed and care reappraised to ensure that the patient’s needs are being met. The main aim of this study is to evaluate the reliability and validity of the Byron Physical Assessment Framework (BPAF). the study involved scrutinising the BPAF to describe its purpose, conceptual basis and how it was developed. The BAF was then refined using extensive literature review and expert opinion to improve its comprehensiveness and clarity for its intended purpose. This monograph should be useful to all those attempting to construct and validate clinical assessment and measuring tools. Ruth Harris has the expertise necessary to do this in a sophisticated yet realistic way for practice colleagues.Table of ContentsAssessment Tools. Development and Refinement of The Byron Physical assessment Framework. Evaluation of The Reliability of The Byron Physical assessment Framework. Evaluation of The Validity of The Byron Physical assessment Framework. Discussion. Appendix 1 - Physical Assessment Teaching information for Staff. Appendix 2 - Second Version of The Nursing-led Inpatient unit (nliu) Physical Assessment Framework. Appendix 3 - First Version of The nliu Physical Assessment Framework. Appendix 4 - Abnormal Physiological Signs and Symptoms of The Cardiovascular System. Appendix 5 - Abnormal Physiological signs and Symptoms of The Neurological System. Appendix 6 - Abnormal physiological Signs and Symptoms of The Gastrointestinal System. Appendix 7 - abnormal Physiological Signs and Symptoms of The Genitourinary System. Appendix 8 - Definition of Items on The Byron Physical Assessment Framework Before refinement by Expert Group. Appendix 9 - Definition of Items on The Bryon physical Assessment Framework After Refinement by Expert Group.
£53.15
John Wiley & Sons Inc Qualitative Research in Health Care
Book SynopsisThis is a comprehensive book with theoretical and practical input for health care researchers exploring the humanistic and individual aspects of health and illness. It covers the main qualitative research methods and provides clear, concise and well-evidenced clinical information for researchers from all disciplines.Table of ContentsUsing Qualitative Research in Health Care. Using Focus Groups in qualitative Healthcare Research. Using Action Research in Qualitative healthcare Research. Using Grounded Theory in Qualitative Healthcare Research. Using Illuminative Case Studies in Qualitative Healthcare Research. Using ethnography Case Studies in Qualitative Healthcare Research. Using Phenomenolgy in Qualitative Healthcare Research. Using Historic Analysis in Qualitative healthcare Research. Index.
£43.65
John Wiley & Sons Inc Profound Deafness and Speech Communication
Book SynopsisDrawing together contributions from a broad selection of internationally recognized experts in the field, this book aims to provide an up-to-date summary of research concerned with speech perception and production in profoundly hearing-impaired children and adults. Following introductory chapters provided by Professor Gunnar Fant of the Department of Speech Communication and Music Acoustics in Stockholm, and Professor Harry Levitt of the City University of New York, the main body of the book is divided into four sections covering tactile aids, cochlear implants, speech perception and speech production.Table of ContentsList of Contributors. Foreword (Gunnar Fant). Preface (Geoff Plant and Karl-ERik Spens). 1. Sensory Aids for Deaf People: Past, Present and Future (Harry Levitt). PART I: TACTILE AIDS. 2. Tactile Aids: A Personal Perspective (James M. Pickett). 3. Tactiling and Tactile Aids: A User's Viewpoint (Gustaf Soderlund). 4. Tadoma: An Overview of Research (Charlotte M. Reed). 5. Design Fundamentals for Eletrotactile Devices. The Tickle Talker Case Study (Robert S.C. Cowan, Karyn L. Galvin, Peter J. Blamey and Julia Z. Sarant). 6. Education of Deaf Children with Tactual Aids: The Miami Experience (D. Kimbrough Oller, Kathleen Vergara and Rebecca E. Eilers). 7. Tactile Aid Usage in Young Deaf Children (Adele Proctor). 8. Toward Future Tactile Aids (Lynne E. Bernstein). PART II: COCHLEAR IMPLANTS. 9. Cochlear Implants: Historical Perspectives (Graeme M. Clark). 10. The Cochlear Implant: A Weapon to Destroy Deafness or a Support for Lipreading?: A Personal View (Anita Wallin). 11. Speech Perception and Production Skills in Children with Cochlear Implants (Mary Joe Osberger). 12. Speech Perception for Adults Using Cochlear Implants, (Richard C. Dowell). 13. Speech Production by Adults Using Cochlear Implants (David House). PART III: SPEECH PERCEPTION AND TESTING. 14. Speech Related to Pure Tone Audiograms (Gunnar Fant). 15. What Makes a Good Speech Test? (Harvey Dillon and Teresa Ching). 16. Speech Perception Tests and Heating-impaired Children (Arthur Boothroyd). 17. Speech Perception Tests for Use with Australian Children (Geoff Plant). 18. What Makes a Skilled Speechreader? (Jerker Ronnberg). 19. Evaluation of Speech Tracking Results: Some Numerical Considerations and Examples (Karl-Erik Spens). PART IV: SPEECH PRODUCTION. 20. Principles for a Complete Description of the Phonological System of Deaf Children as a Basis for Speech Training (Anne-Marie Oster). 21. The Use of Sensory Aids for Teaching Speech to Children who are Deaf (James Mahshie). 22. Speech Pattern Elements in Assessment, Training and Prosthetic Provision (Adrian Fourcin and Evelyn Abberton). 23. Speakers and Hearers are People: Reflections on Speech Deterioration as a Consequence of Acquired Deafness (Roddy Cowie and Ellen Douglas-Cowie). 24. Speech Visualization System as a Basis for Speech Training and Communication Aids (Akira Wartanabe). PART V: COMPUTER-BASED TRAINING. 25. A Multi-media Program for Exercising the Basics in Lipreading, Cued Speech and Sign Language Vocabulary (Birgit Cook). 26. Computer-assisted Interactive Video Methods for Speechreading Instruction: A Review (Donald G. Sims and Linda Gottermeier). Index.
£144.85
Springer Nature Switzerland AG Bioinformatics: An Introduction
Book SynopsisThis invaluable textbook presents a self-contained introduction to the field of bioinformatics. Providing a comprehensive breadth of coverage while remaining accessibly concise, the text promotes a deep understanding of the field, supported by basic mathematical concepts, an emphasis on biological knowledge, and a holistic approach that highlights the connections unifying bioinformatics with other areas of science.The thoroughly revised and enhanced fourth edition features new chapters focusing on regulation and control networks, the origins of life, evolution, statistics and causation, viruses, the microbiome, single cell analysis, drug discovery and forensic applications. This edition additionally includes new and updated material on the ontology of bioinformatics, data mining, ecosystems, and phenomics. Also covered are new developments in sequencing technologies, gene editing methods, and modelling of the brain, as well as state-of-the-art medical applications. Of special topicality is a new chapter on bioinformatics aspects of the coronavirus pandemic.Topics and features: Explains the fundamentals of set theory, combinatorics, probability, likelihood, causality, clustering, pattern recognition, randomness, complexity, systems, and networks Discusses topics on ontogeny, phylogeny, genome structure, and regulation, as well as aspects of molecular biology Critically examines the most significant practical applications, offering detailed descriptions of both the experimental process and the analysis of the data Provides a varied selection of problems throughout the book, to stimulate further thinking Encourages further reading through the inclusion of an extensive bibliography This classic textbook builds upon the successful formula of previous editions with coverage of the latest advances in this exciting and fast-moving field. With its interdisciplinary scope, this unique guide will prove to be an essential study companion to a broad audience of undergraduate and beginning graduate students, spanning computer scientists focusing on bioinformatics, students of the physical sciences seeking a helpful primer on biology, and biologists desiring to better understand the theory underlying important applications of information science in biology.Dr. Jeremy Ramsden is Hon. Prof. of Nanotechnology in the Department of Biomedical Research at the University of Buckingham, UK.Table of Contents
£75.99
Springer Nature Switzerland AG Mechanisms of Gene Regulation: How Science Works
Book SynopsisThis textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.Table of Contents1 Genes and chromatin1.1 Central dogma of molecular biology1.2 Impact of chromatin structure1.3 Epigenetics enables gene expression1.4 Gene regulation in the context of nuclear architecture2 Basal transcriptional machinery2.1 Core promoter2.2 TATA box and other core promoter elements2.3 Genome-wide core promoter identification2.4 TFIID and Mediator as paradigms of multi-protein complexes3 Transcription factors and signal transduction3.1 Site-specific transcription factors and their domains3.2 Classification of transcription factors3.3. Activation of transcription factors3.4 Programing cellular differentiation by transcription factors3.5 Inflammatory signaling via NF-B3.6 Sensing cellular stress via p534 A key transcription factor family: Nuclear receptors4.1 The nuclear receptor superfamily4.2 Molecular interactions of nuclear receptors4.3 Physiological role of nuclear receptors5 Genome-wide principles of gene regulation5.1 Next-generation sequencing5.2 Gene regulation in the context of Big Biology5.3 Exploring genome-wide transcription factor binding5.4 Integrating epigenome-wide datasets6 Chromatin modifiers6.1 Cytosines and their methylation6.2 Histone modifications6.3 Gene regulation via chromatin modifiers6.4 Sensing energy metabolism via chromatin modifiers7 Epigenetics7.1 Epigenetics and chromatin7.2 Genome-wide understanding of epigenetics7.3 CTCF and genetic imprinting7.4 Epigenetics in health and disease8 Chromatin remodeling and organization8.1 Nucleosome positioning at promoters8.2 Chromatin remodeling8.3 Transcriptional dynamics in the presence of chromatin8.4 Organization of the nucleus9 Regulatory impact of non-coding RNA9.1 Non-coding RNAs9.2 miRNAs and their regulatory potential9.3 Long ncRNAs9.4 Enhancer RNAs
£56.99
Springer Nature Switzerland AG Studies of Epithelial Transporters and Ion
Book SynopsisThis book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. The focus of this volume lies with different ion channel and transporter families. Additionally, this volume benefits from pharmaceutical contributors and their insights into recent pre-clinical drug discovery efforts and results from clinical trials. Overall, these chapters offer a more thorough coverage of individual epithelial ion channels and transporters from the 1st Edition, along with eleven new chapters. That makes Volume 3 an insightful contribution for physiology students, scientists and clinicians.Table of Contents1. Na+/K+-ATPase Drives Most Asymmetric Transports and Modulates the Phenotype of Epithelial Cells.- 2. Na+-K+-2Cl- Cotransporter.- 3. Thiazide-sensitive NaCl Cotransporter.- 4. NBCe1, an Electrogenic Na+ Bicarbonate Cotransporter, in Epithelia.- 5. Na+/H+ Exchangers in Epithelia.- 6. Sugar Transport Across Epithelia.- 7. Amino Acid Transporters of Epithelia.- 8. Structure-Dynamic and Regulatory Specificities of Epithelial Na+/Ca2+ Exchangers (NCX).- 9. Urea Transporters in Health and Disease.- 10. H,K-ATPases in Epithelia.- 11. Zinc Transporters Involved in Vectorial Zinc Transport in Intestinal Epithelial Cells.- 12. Properties, Structure and Function of the Solute Carrier 26 Family of Anion Transporters.- 13. ClC-2 Chloride Channels.- 14. The Role of the Endosomal Chloride/Proton Antiporter ClC-5 in Proximal Tubule Endocytosis and Kidney Physiology.- 15. CFTR and Cystic Fibrosis: A Need for Personalized Medicine.- 16. Molecular Physiology and Pharmacology of the Cystic Fibrosis Transmembrane Conductance Regulator.- 17. TMEM16 Proteins (Anoctamins) in Epithelia.- 18. Epithelial Sodium Channels (ENaC).- 19. ROMK and Bartter Syndrome Type 2.- 20. Inwardly-rectifying K+ channel 4.1 regulates renal K+ excretion in the aldosterone-sensitive distal nephron.- 21. Small-molecule Pharmacology of Epithelial Inward Rectifier Potassium Channels.- 22. KCa3.1 in Epithelia.- 23. BK Channels in Epithelia.- 24. Recent Developments in the Pharmacology of Epithelial Ca2+-Activated K+ channels.- 25. KCNE regulation of KCNQ channels.- 26. Orai Channels.- 27. Trp Channels in Renal Epithelia.- 28. P2X receptors in Epithelia.- 29. The Polycystins and Polycystic Kidney Disease.- 30. Renal Aquaporins in Health and Disease.
£999.99
Springer Nature Switzerland AG Biomedical Visualisation: Volume 9
Book SynopsisThis edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will also be able to learn about the use of visualisation techniques and technologies for the historical and forensic settings.The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences.In this volume, there are chapters which examine forensic and historical visualisation techniques and digital reconstruction, ultrasound, virtual learning resources and patient utilised software and hardware. The use of HoloLens as a disruptive technology is discussed as well as historical items as a feature in a modern medical curriculum. It concludes with a fascinating chapter on pulse extraction from facial videos. All in all, this volume has something for everyone whether that is faculty, students, clinicians and forensic practitioners, patients, or simply having an interest in one or more of these areas.Table of ContentsPlease see attachment
£98.99
Springer Nature Switzerland AG Tumor Suppressor Par-4: Structural Features,
Book SynopsisPar-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar’s laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule’s structural features, key functional domains, regulation and relevant basic and clinical/translational facets.Table of ContentsIntroductionChapter 1. Discovery and Overview of Par-4Chapter 2. Significance of Par-4 Interaction with aPKCChapter 3. Structural Analysis of the C-terminal domain of Par-4Chapter 4. Crystallization and crystallographic analysis of the C-terminal domain of Par-4 (PAWR)Chapter 5. Role of ubiquitinase FBX045 in Par-4 regulationChapter 6. Regulation of Par-4 by type II phosphatidylinositol 4-kinase βChapter 7. Role of Par-4 in regulation of cell death by circumin and ceramideChapter 8. Par-4 in dissociation induced cell death in human pluripotent stem cellsChapter 9. Role of Par-4 in EMTChapter 10. Bacillus thuringiensis Induced Par-4 and Apoptosis in Human CellsChapter 11. Role of Par-4 in ZebrafishChapter 12. Role of Par-4 in GRP78 translocationChapter 13. Interaction of THAP1 with Par-4 in PML bodiesChapter 14. Regulation of DAPK and AMIDA by Par-4Chapter 15. Regulation of Par-4 by CK2 kinase
£134.99
Springer Nature Switzerland AG Broadly Engaged Team Science in Clinical and
Book SynopsisDespite the large U.S. investment in health science, and the vast and growing body of peer-reviewed research findings it has produced, a compelling body of evidence suggests that research too often has been slow, inefficient, and fallen short of desired impacts on health. A key question is how research might be changed to be more innovative, less wasteful, and more responsive to unmet health needs. One emerging response within clinical and translational science is to advance an approach that attempts to close the gap between research scientists and key stakeholders; the individuals and groups responsible for or affected by health-related decisions. Broadly engaged team science promises to support this aim by transforming the gold standard, multi-disciplinary team science, to include key stakeholders in activities across the research spectrum. These new roles and responsibilities range from generating research questions to implementing research projects, to aiding in the translation of discoveries from the laboratory to the community. A transition to broadly engaged team science reflects the idea that inclusivity and a diversity of perspectives are necessary to achieving progress in addressing complex health issues while representing a new benchmark for ethical research practice. This is one of the first collections of papers describing how clinical and translational science researchers are defining and implementing new research practices, and the successes and challenges involved. This book represents a first and critical step towards organizing knowledge of broadly engaged team science and advancing the development of evidence-based practices. Written in an accessible style, this book is intended to highlight the breadth of broadly engaged team science within one community, motivate researchers and stakeholders to build inclusive teams, bring rigor to often informal stakeholder engagement research practices and encourage people to think more broadly about the development of scientific knowledge. It includes examples of multi-disciplinary, broadly engaged team science projects, the perspectives of academic leaders about the changes needed to encourage scientists to conduct broadly engaged team science, and a resource directory.Table of Contents1. IntroductionAlice Rushforth and Harry SelkerPart I Transforming Research with Broad Engagement2. The Transformative Power of Broadly Engaged Team Science: A Mother’s Quest to Understand PXESharon Terry3. Broadly Engaged Team Science in Neonatal ResearchJonathan M. Davis4. Patient Advocates in Cancer Care: A Rich Tradition and Evolving RoleSusan K. Parsons5. National Kidney Foundation Patient Network Silvia Ferrè, Silvia Titan and Lesley A. Inker6. Broadly Engaged Team Science Comes to Life in a Design LabMarisha E. Palm, Harry Selker, Theodora Cohen, Kenneth Kaitin, Kay Larholt, Mark Trusheim and Gigi Hirsch7. Tufts Center for the Study of Drug Development Employs Broadly Engaged Team Science to Explore the Challenges of Pharmaceutical Research and DevelopmentKenneth I. Kaitin and Kenneth GetzPart II. Integrating Communities and Stakeholders into Broadly Engaged Team Science8. Social Movements and Stakeholder Engagement Peter Levine9. A Basic Scientist’s Journey: Engaging Public Stakeholders Through Civic ScienceJonathan Garlick10. Lessons in Public Involvement from Across the PondMarisha E. Palm, Tina Coldham and David Evans11. Leveling the Playing Field for Community Stakeholders: Examining Practices to Improve Engagement and Address Power DynamicsSara Folta, Linda B. Hudson, Beverly Cohen and Apolo Cátala12. A Theory of Stakeholder-driven Community DiffusionErin Hennessy and Christina Economos13. Monitoring and Evaluation of Stakeholder Engagement in Health ResearchThomas W. Concannon and Marisha E. PalmPart III. Applying Broadly Engaged Team Science: Case Studies14. Insiders and Outsiders: A Case Study of Fostering Research Partnerships between Academic Health Centers and Corrections InstitutionsAlysse G. Wurcel, Julia Zubiago, Deirdre J. Burke, Karen M. Freund, Stephenie Lemon, Curt Beckwith, John B. Wong, Amy LeClair and Thomas W. Concannon15. Responding to the Community: HOPE (Healthy Outcomes from Positive Experiences)Robert Sege, Dina Burstein and Chloe Yang16. Students as Key Collaborators in Tackling Early Stage Research IdeasAlissa Dangel and Mallory Whalen17. Engaging Stakeholders to Decrease Study Start-up DelaysDenise H. Daudelin, Alyssa Cabrera, Alicea Riley and Jaime Chisholm18. Health Literacy and Broadly Engaged Team Science: How One Study Team Used Plain Language Principles to Share Findings with Affected CommunitiesSabrina Kurtz-Rossi, Doug Brugge and Sylvia Baedorf Kassis19. Utilizing Patient Navigators to Promote Equitable and Accountable ResearchMingqianLin, Douglas Hackenyos, Fengqing Wang, Nicole Savidge, Angela Wimmer, Antonia Maloney, Susan Mohebbi, Michele Guard and Susan K. Parsons20. Asian American Research in the Post-Atlanta Era: Driving Community-engaged Research That Is More Meaningful, Responsive, and Actionable for Local CommunitiesCarolyn Leung Rubin, Ben Hires, Dawn Sauma and Yoyo Yau21. Stakeholder Engagement in Predictive Model Development for Clinical Decision SupportDenise H. DaudelinPart IV. Creating an Institutional Environment of Support for Broadly Engaged Team Science22. Research Administration Practices for Proposal Development and Post-Award Management of Stakeholders and Community ParticipantsCarol Seidel23. Starting Off Right: Supporting Community Involvement in the Evaluation of Research ProposalsRobert Sege and Marguerite Fenwood24. Role of Broadly Engaged Team Science in the Inclusion of Minority Populations as Research Participants and in All Roles on Research TeamsPamela B. Davis and Harry P. Selker25. Rewarding Team Science in Tenure and Promotion Practices: An Operational Imperative for the Academic Research Enterprise of the 21st CenturyAugusta Rohrbach and Caroline Attardo GencoEpilogueDebra Lerner, Thomas W. Concannon and Marisha E. PalmResource Guide
£999.99
Springer Nature Switzerland AG Gene and Cellular Immunotherapy for Cancer
Book SynopsisClinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more. Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field.Table of ContentsPart I: Overview1. The History of Cellular Therapies 2. Basics of Immunity Part II: CAR-T3. Biology of CAR-T 4. Cell Types Used for CAR-T Generation5. Combination Therapeutics with CAR-T Cell Therapy 6. Safety Switches Used for Cellular Therapies7. Off the Shelf CAR-T8. Manufacturing of CAR-T Cells: the Assembly Line9. Navigating Regulations in Gene and Cell Immunotherapy10. Bringing CAR-T to the Clinic11. CAR-T Cell Complications 12. Mechanisms of Resistance and Relapse after CAR-T Cell Therapy Part III: TIL13. Tumor Infiltrating Lymphocytes (TIL): From Bench to Bedside Part IV: TCR14. T-cell Receptor (TCR) Engineered Cells and Their Transition to Clinic Part V: Viral CTLs15. Viral Cytotoxic T Lymphocytes (CTLs): from Bench to BedsidePart VI: NK Cell16. Biology of NK Cells and NK Cells in Clinic Part VII: T/NK cell engagers17. Biology and Clinical Evaluation of T/NK Cell Engagers Part VIII: Logistics 18. Roadmap for Starting an Outpatient Cellular Therapy Program
£116.99
Springer Nature Switzerland AG The Pathway to Publishing: A Guide to
Book SynopsisWriting manuscripts is central to the advance of scientific knowledge. For an early career aspiring scientist, writing first author manuscripts is an opportunity to develop critical skills and to credential their expertise. Writing manuscripts, however, is difficult, doubly so for scientists who use English as a second language. Many science students intentionally avoid a writing-intensive curriculum. Careful, thorough reviews of draft manuscripts are difficult to secure, and experienced scientific supervisors face more demands on their time than they have time available. Weak draft manuscripts discourage supervising scientists investing the time to coach revisions. It is easier for experienced scientists to ignore the request, or to simply rewrite the article. Early career scientists are motivated to address these barriers but specific advice is difficult to find, and much of this advice is behind a pay wall. This essential, open access text presents writing lessons organized as common errors, providing students and early-career researchers with an efficient way to learn, and mentors with a quick-reference guide to reviewing. Error descriptions include specific examples drawn from real-world experiences of other early-career writers, and suggestions for how to successfully address and avoid these in the future. Versions of this book have been used by Stanford University, UC Davis, Johns Hopkins, and numerous international institutions and organizations for over a decade. Table of Contents1. Introduction1.1 The pathway to publishing1.2 Think before you write approach1.2.1 Develop a framing document1.2.2 Focus on the high level outline (HLO)1.2.3 Use the ‘most common errors’1.2.4 Understand authorship and mentoring responsibilities1.2.5 Structure the writing and feedback process1.3 The scientific writing style1.4 Converting preliminary work into manuscripts1.4.1 Converting reports into manuscripts1.4.2 Converting posters and verbal presentations into manuscripts1.5 The process of peer review2. Most common errorsA. General research and writing practicesA1. Insufficient knowledge of the literatureA2. Not referencing statementsA3. Weak citations A3a. Citing a secondary sourceA3b. Presenting conclusions rather than data from referencesA3c. Arguing from authorityA4. Endnotes not in standard styleA4a. Varying endnote notationA5. Not using standard draft manuscript formA6. Repeating informationA7. Labelling a scientific document as ‘final’A8. Characterizing an observation as ‘the first’A9. Errors in reasoningA9a. Casual assertion of causalityA9b. Assuming association is causalityA9c. Assuming reported behavior reflects actual behaviorA9d. Confusing imperfect recall with recall biasA9e. Confusing absence of recognition with absenceA9f. Asserting seasonality with a single year of dataA9g. Drawing conclusions using confirmation biasA10. Constructing a multivariate model using only statistical criteriaA11. PlagiarismB. Content of quantitative papersB1. Improper focus or format of title and abstractB2. Confusing the role of Introduction, Methods, Results, and DiscussionB3. Not writing the Methods section in chronological orderB4. Not emphasizing steps taken to protect human subjectsB5. Listing interpretations, but not defending one in the DiscussionB6. Not fully explaining limitationsB7. Writing generic recommendationsB8. Presenting new data in the DiscussionB9. Reporting the number of enrolled subjects in the MethodsB10. Specifying the contents of a questionnaireB11. Naïve theories of changeB11a. Recommending a massive increase in fundingB11b. Ignoring incentives and barriersB11c. Assuming weak states can implementB12. An insufficiently focused IntroductionB13. Failure to clarify key sample size assumptionsB14. A high level outline that is not high levelB15. Specifying software used for routine data analysisB16. Presenting rationale in the last sentence of the IntroductionC. Mechanics of writingC1. Using non-standard abbreviationsC2. Using non-standard spacesC3. Improper spellingC4. Capitalization problems C4a. USING ALL CAPITAL LETTERSC4b. Capitalizing non-proper nounsC5. Failure to spell out an isolated numeral < 10C6. Starting a sentence with a numeralC7. Not indenting paragraphsC8. Not aligning text to the leftC9. Problems with parenthesesC10. Not recognizing when an abbreviation has become a nameC11. Misplaced commas in large numbersC12. Varying fonts within the narrativeC13. Using bulleted lists rather than sentencesC14. Uninformative document namesD. Grammatical structures and stylistic strategiesD1. Using present rather than past tenseD2. Failure to use definite and indefinite articlesD3. Excessive use of passive voiceD4. Improper use of “we”D5. Writing from a psychological perspectiveD6. Using excessive sub-headings in the discussion sectionD7. Misplaced modifiersD8. Using nouns with awkward syntax in place of verbsD9. Using different terms for the same object or the same ideaE. Achieving clarity and concisenessE1. Labelling rather than explainingE2. Using weak opening phrases for sentencesE3. Using adjectives and qualifiersE4. Overusing studies or authors as sentence subjectsE5. Using non-descriptive numeric or alphabetical labelsE6. Using respectivelyE7. Using the word etceteraE8. Using foreign wordsE9. Using local words, expressions or monetary figuresE10. Using the term ‘developing country’E11. Using the term ‘socio-economic status’ as a synonym for wealthE12. Using a technical term in its non-technical senseE12a. Using the term ‘random’ in its non-technical senseE12b. Using the term ‘reliable’ in its non-technical senseE12c. Using the term ‘significant’ in its non-technical senseE12d. Using the term ‘valid’ in its non-technical senseE12e. Using the term ‘incidence’ incorrectlyE12f. Using the term ‘correlated’ incorrectly E13. Using the verb ‘documented’E14. Framing an argument in terms of needE15. Using the term ‘illiterate’ as a synonym for ‘no formal education’E16. Using the word ‘challenging’ as a synonym for ‘difficult’E17. Describing a laboratory test result as positiveE18. Using increase or decrease in the absence of a time trendE19. Describing a test as a gold standardF. Recording scientific dataF1. Using statistics in place of the study question to frame resultsF1a. Framing narrative results around p-valuesF2. Not presenting the core dataF3. Using too many decimal placesF4. Using too few decimal placesF5. Using incomplete headings for tables and figuresF6. Imbalance between table and narrative presentation of the resultsF7. Pointing too explicitly to tables and figuresF8. Using inappropriate figuresF9. Using the wrong symbol to designate degreeF10. Using non-standard footnote symbols in tablesF11. Comparing to a varying baselineF12. Generic data tables that lack a clear messageF13. Table layout that impairs comparisons*F14. Maps with irrelevant detailsF15. Numbering figures or tables out of sequenceF16. Listing results in a paragraph that are more clear in a tableF17. Using less informative denominators in a tableF18. p-value in a baseline table of a randomized controlled trialF19. Emailing draft manuscripts with figures that are not compressedG. Approaching publicationG1. Failure to respond to reviewers’ commentsG2. Incomplete response to reviewsG3. Invalid authorship line G4. Missing acknowledgement sectionG5. Choosing an inappropriate journalG6. Not following a specific journal’s details of styleG7. Not using a checklist to review your paper before submissionG8. Exceeding the journal word limitG9. Asking your senior author to recommend reviewersG10. Responding to journal reviewers using the first person singularG11. Retaining comments in subsequent draftsG12. Not finding a description of the error codeG13. Requesting an unprofessionally short turnaround timeG14. Sending blank forms for co-authors to completeG15. Not providing co-authors a copy of the submitted manuscriptG16. Not keeping co-authors informed of journal discussionsG17. Re-using an email thread when circulating a revised manuscriptG18. Not proofreading references prior to submissionG19. Not including text of the manuscript changes in response to reviewersG20. Not including readability statisticsH. Slide and poster presentationsH1. Bullets on the wallH2. Chart junkH3. Copying a manuscript figure instead of developing a custom figureH4. Photos with an unnatural aspect ratioH5. Too many photographs on a single slideH6. Field workers as the dominant subject of photographsH7. Using bullets without hanging indentsH8. Using a pie chartH9. Using vertical bars when horizontal bars would communicate betterH10. Including a final “Thank you” slideH11. Using sentences for bullet pointsH12. Too much space between bulletsH13. Failure to separate ideas in a multi-lined titleH14. Using 3 dimensional chart features as decorationsAppendix 1: Flowchart for reviewing scientific documents Appendix 2: Concept note outlineAppendix 3: Critical questions for protocol developmentAppendix 4: Framing documentAppendix 5: Conference/scientific meeting abstractsAppendix 6: Quantitative manuscript high level outline (HLO)Appendix 7: Example of quantitative manuscript HLOAppendix 8:Authorship Scorecard Appendix 9:JANE (Journal/Author Name Estimator)Appendix 10: STROBE StatementAppendix 11: CONSORT StatementAppendix 12: List of common errors Appendix 13: Concept note exampleReferences
£34.99
Springer Nature Switzerland AG Fundamentals and Advances in Medical
Book SynopsisThis book serves as an introduction to the concepts of medical biotechnology, with great details about fundamentals and early disciplines of study as well as emerging fields and the latest research. The book follows a chronological order from the earliest discoveries and breakthroughs of medical biotechnology to the latest areas of study. The book contains up-to-date citations for each chapter and section, which makes it easy for the reader to understand the concept and also to follow the latest developments in the particular area. It is an ideal book for undergraduate and graduate students who aspire to derive basic knowledge and are also keen on learning about the latest advancements in the field of medical biotechnology. Table of ContentsChapter 1. The Advent of Medical Biotechnology Dr. Zeenat Farooq, Dr. Mumtaz AnwarChapter 2. Biotechnology in Medicine: FundamentalsDr. Pooja MalhotraChapter 3. Biotechnology in Medicine: Advances-IDr. Hafeez Faridi, Dr. Mohd ShahidChapter 4. Biotechnology in Medicine: Advances IIDr. Zeeshan Zahoor BandayChapter 5. Analytical Techniques in Medical BiotechnologyDr. Shubha PriyamvadaChapter 6. Immunology in Medical BiotechnologyDr. Sajad Ahmad BhatChapter 7. Epigenetics and Medical BiotechnologyDr. Altaf Bhat, Dr. Zeenat FarooqChapter 8. Stem Cell TechnologyDr. Willayat Yousuf WaniChapter 9. Pharmaceutical BiotechnologyD.r Mohammad TauseefChapter 10. Diagnostic and Therapeutic BiotechnologyDr. Ashvinder Raina, Dr. Aadil Hussain BhatChapter 11. Nanotechnology and NanomedicineDr. Abhalaxmi SinghChapter 12. Laboratory Protocols in Medical Biotechnology - IDr. Mohsin MaqboolChapter 13. Laboratory Protocols in Medical Biotechnology - IIDr. Medha PriyadarshiniChapter 14. Ethics and Medical BiotechnologyDr. Mohd Saleem Dar, Dr. Syed Mudasir AhmadChapter 15. Career Opportunities in Medical BiotechnologyDr. Saroj Nepal
£161.99
Springer Nature Switzerland AG Are Electromagnetic Fields Making Me Ill?: How
Book SynopsisElectricity and Magnetism (E&M) underlies many lifesaving medical devices, such as magnetic resonance imaging scanners, neural stimulators, and heart pacemakers. But E&M also attracts its share of bogus health claims, such as biomagnetic therapy. How do you separate the good from the bad? Sometimes it’s not easy: experiments are prone to artifacts, theories are limited by assumptions, and clinical trials can result in ambiguities. In this book, the author separates the wheat from the chaff, showing which applications of E&M are bogus and which are not. This book takes the reader on a tour through a range of fascinating phenomena, from effects that are constant in time at one extreme, such as transcranial direct current stimulation of the brain, to the millimeter-wave whole-body scanners which are familiar to frequent flyers at the other. Along the way, the author looks in depth at the dispute about power line magnetic fields and leukemia, a case study in what can go wrong when dubious claims inflame unjustified fears. The debate about cell phones and brain cancer still rages today, particularly for the microwave frequencies encountered with new 5G technology. Recently, the so-called Havana Syndrome has been attributed to microwave weapons, but the underlying biophysics of such weapons is unclear. For all these encounters with electricity and magnetism, the author, an eminent biophysicist, uses science and evidence to sort out fact from fantasy. This book is aimed at general readers who want to make sense of the mysterious and often controversial ways in which E&M interacts with the human body. It is also ideal for students and professionals in bioscience and health-related fields who want to learn more without getting overwhelmed by theory.Trade Review“This book is an essential reference that would be a great addition to every skeptic’s bookshelf. It summarizes the evidence about the health effects of electromagnetism and provides ammunition for debunking pseudoscientific rumors. It’s short, inexpensive, well-written, and full of interesting facts. I was particularly intrigued to learn that an electric eel has its own Twitter account.” (Harriet Hall, Science-Based Medicine, sciencebasedmedicine.org, June 14, 2022)Table of ContentsChapter 1: Can Magnets Cure All Your Ills?Chapter 2: Can a 9-Volt Battery Make You Smarter? Chapter 3: Do Power Lines Cause Cancer? Chapter 4: Can Electrical Stimulation Eliminate Pain? Chapter 5: Is Your Cell Phone Killing You? Chapter 6: Did Cubans Attack an American Embassy with Microwaves? Chapter 7: Are Whole Body Scanners at Airports Dangerous?
£23.74
Springer Nature Switzerland AG Microscopic Techniques for the Non-Expert
Book SynopsisThis book covers fundamental microscopic techniques for Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Atomic Force Microscopy (AFM), and other microscopic tools. It provides step-by-step instructions and explanations of the basic fundamental concepts and mechanisms and guides the reader on resolving queries related to taking and analyzing microscopy images. The latest advancements and developments in microscopic equipment are described. Theoretical background on microscopy is also provided to enhance the reader’s understanding of microscopy techniques and tools. Microscopic Techniques for the Non-Expert is an ideal book for undergraduate and postgraduate students, as well as researchers with a background in environmental science, materials science, biomedicine, engineering, or bio-nanotechnology.Table of ContentsA Beginner’s Guide to Different Types of Microscopes Principles of Light and Fluorescence Microscopy Confocal and Multiphoton Microscopy Scanning Probe Microscopy: tipping the path towards atomic visions Atomic Force Microscopy - An Advanced Imaging Technique: From Molecules to Morphologies Exploring the microcosm at atomic precision using Atomic Force Microscopy Scanning Electron Microscopy (SEM): Learning to generate and interpret the topographical aspects of materials Recent updates on methods, applications, and practical uses of scanning electron microscopy in various life sciences Transmission electron microscopy - A powerful and novel scientific technique with nanoscale resolution for characterization of materials Preparation of Biological Samples for SEM: Techniques and Procedures
£104.49
Springer International Publishing AG Novel Innovation Design for the Future of Health:
Book SynopsisThis book highlights the reasons for an urgently needed revision of the current global healthcare setup, discusses the needed mindset for a future of health, and provides a comprehensive development toolset for disruption (and for the needed incremental innovations towards disruption).Today’s biomedical and health innovation related research in universities encourages activities that lead to incremental innovations with a relatively low risk of failure. The healthcare industry on the other hand provides tools and devices for established healthcare providers to improve the diagnosis and therapy/ treatment of the patients’ health problems. The patient is not in the center of healthcare provision however, and prevention and prediction are not core goals. The current health setup needs to be challenged and disrupted.Disruptions are coming from technologies or processes that lead to a significant (>10x) reduction in cost or price/ performance and that also come with new business models. The need for change, effects of exponential technologies, and the needed shift to prevention and to homecare for health democratization and patient empowerment will be discussed in detail in the first parts of the book. The subsequent sections address several innovation methods with a focus on a novel meta methodology named Purpose Launchpad Health. This is followed by a comprehensive discussion on health entrepreneurship activities and needs. The final section of the book addresses how to train students to become entrepreneurial health innovators, presenting successful curricula and examples of health incubation and accelerator setups. All of the innovation tools presented and used in this book are summarized in the final chapter to help the reader get started planning an entrepreneurial venture.Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments. Chapters are concise and enriched with key messages, learning objectives and real innovation examples to bridge theory and practice. This book aims to serve as a teaching base for health innovation design and to prepare for health-related entrepreneurial ventures.Readers with medical, biomedical, biotechnology, and health economics backgrounds - and anyone who wants to become a future oriented health innovator or who believes in disruptive approaches - will find this book a useful resource and teaching tool for developing validated products/ services and processes for the future of health.Table of ContentsPart I. What Is Wrong with Health? What Should the Future of Health Be?.- INNOVATION DESIGN for the FUTURE of HEALTH.- Health Innovations from an Innovators’ Perspective.- From SICKCARE to HEALTHCARE to HEALTH.- Future Look on Health: Opportunities.- Navigating Towards a Future of “One Health”.- Part II. Exponential Medicine + Technologies + Mindset.- Exponential Technologies for an Exponential Medicine.- Exponential Medicine: Challenges of Human Spaceflight Bringing Innovations for Earth—A Case Study.- Healthy Longevity.- The Science of Health Longevity.- Space Healthtech: Innovation Base for Longevity.- Part III. Future Health Value Propositions.- Healthcare the Melting Pot of Technology, Humanity, and Confusion.- Democratize Health Delivery.- Health Innovation Process: Definitions and Short Methodology Introductions.- Prevention, Prediction, Personalization, and Participation as Key Components in Future Health.- Digital Health Business Models: Transformation Is on the Horizon.- Value Propositions for Future Health Developments: Digital, Portable, Connected, Experience-Enhancing, Supportive, Patient-Centric, and Affordable.- (Digital) Patient Journey and Empowerment: Digital Twin.- Part IV. Innovation Methodology Basics.- Stanford Biodesign as Base: Empathy and Patient Centricity as the Main Driver.- Purpose Launchpad Methodology: Introduction.- Design Thinking for Innovations in Healthcare.- VPC to BMC to Exponential Canvas: Canvas Interconnectivity for Exponential Scaling.- Innovation Methodology I3 EME: Awareness for Biomedical Engineers.- Part V. Ethics + Health Innovation.- Integrating Ethical Considerations into Innovation Design.- Part VI. Health Innovation Design.- Case Studies Used Throughout the Book: Innovation Categories Explained.- Why Is Healthcare Different with Respect to Innovation and Entrepreneurial Activities?.- Purpose Launchpad Health (PLH) Methodology Introduction.- Part VII. Purpose Launchpad Health.- Purpose Launchpad Health: Exploration and Evaluation Phases—Actual Case Studies.- Part VIII. Health Leadership, Skills and other Methodologies.- Soft Skills Needed for Problem Understanding and Innovation Generation.- Leadership in Healthcare: A Novel Approach. Healthcare Executives’ Traits, Styles, and Approaches.- Future Skills Framework in Healthcare.- Porter’s Five Forces Analysis: Quo Vadis Immunotherapy Industry.- Part IX. Health Entrepreneurship.- Global Health Markets and Their Different Needs.- Patient: Health Relation and Digital Health Entrepreneurship.- Health Start-Up: Create Impact and be Investment Ready Intra- and Entre-Preneurs.- Regulatory Issues for Health Innovations.- Innovation Think Tank Frameworks for Resolving “The Innovator’s Dilemma” in Healthcare.- A Primer on Patents and IP for Health Innovations.- Successfully Implementing Ambidexterity in the Medical Industry.- Reverse Innovation: Circumvent Digital Health Transformation Issues.- Part X. Health Innovation Education and Incubation.- Health Innovation Design: “CAMPing” for the Unmet Clinical Need.- Health Technology Innovation Generation (HTIG) Lecture and Project Classes at AGH University.- Health Innovation Design at a University: INKA INNOLAB at Otto-von-Guericke-University.- Clinical Innovation at Acibadem Biodesign Center.- Example of a Needs-Driven Innovation Training Program: The BioMedical Design Novo Nordisk Foundation Fellowship Program.- Addressing the Healthcare Needs with Innovation Think Tank Global Infrastructure and its Methodology.- The Power of a Collaborative Ecosystem: Introducing the Edison™ Accelerator.- HealthTec Networks and Clusters (Global): Innovation Clusters in Medtech in Europe.- Leadership-Compass: “Networking and Synapting Empowered by Health Captains”.- Part XI. Purpose Launchpad Health: Toolset Templates and Principles.- PLH Templates and Principles.
£94.99
Springer International Publishing AG Biomedical Visualisation: Volume 12 ‒ The
Book SynopsisThis image-rich book explores the practice as well as the theory of visual representation and presents us with the importance of designing appropriate images for communication to specific target audiences. This includes the appropriate choice of high-tech digital or low-tech analogue technologies in image-making for communication within the medical education, biological research and community health contexts. We hear from medical students about the value of using clay modelling in their understanding of anatomy, from educators and curriculum designers about visual affordances in medical education and from a community-driven project in South Africa about their innovative use of locally designed images and culture-specific narratives for communicating important health information to marginalised communities. A chapter explores the evolution of scientific visualisation and representation of big data to a variety of audiences, and another presents the innovative 3D construction of internal cellular structures from microscopic 2D slices. As we embrace blended learning in anatomy education, a timely chapter prompts us to think further about and contribute to the ongoing discourse around important ethical considerations in the use and sharing of digital images of body donors. This book will appeal to educators, medical illustrators, curriculum designers, post-graduate students, community health practitioners and biomedical researchers.Table of Contentssee attachment
£116.99
Springer International Publishing AG Cancer Stem Cell Markers and Related Network
Book SynopsisThis book entitled “Cancer Stem Cell Markers and Related Network Path-ways” is about cancer stem cell (CSC) markers and the molecular network pathways. CSCs play an important role in the cancer drug resistance, metastasis and recurrence. Epithelial-mesenchymal transition (EMT) is closely related to CSC phenotype.This book covers various aspects of the molecular networks related to CSCs including the important phenotypic change such as EMT. Readers will discover the importance of the identification of CSC markers and EMT-related molecules in CSC network pathways.The CSC signaling pathways and EMT molecular network pathways attract researchers in the field to define the cancer therapeutic targets. Cancer environment is important in the acquisition of CSC phenotype in cells. The revealing of this CSC mystery is across 7 chapters. The topic of this book is particularly relevant to research in the field of cancer and stem cells, as well as the network pathways. We hope that this book helps the readers to be interested in understanding why the CSC concept is important and attractive.Table of Contents1. Epithelial-mesenchymal transition and cancer stem cellsby Shihori Tanabe2. The transcription factors Zeb1 and Snail induce cell malignancy and can-cer stem cell phenotype in prostate cells, increasing androgen synthesis ca-pacity and therapy resistanceby Fernanda López-Moncada, Enrique A Castellón, Héctor R Contreras3. ERBB signaling pathway in cancer stem cellsby Ghmkin Hassan and Masaharu Seno4. Functional and molecular characters of cancer stem cells through devel-opment to establishmentby Said M Afify, Ghmkin Hassan, Hiroko Ishii, Sadia Monzur, Hend M Nawara, Amira Osman, Hagar A Abu Quora, Mona Sheta, Maram H Zah-ra, Akimasa Seno, Masaharu Seno5. Microenvironment in cancer stem cellsby Shihori Tanabe6. Cancer stem cells contribute to drug resistance in multiple different waysby Maram H Zahra, Hend M Nawara, Ghmkin Hassan, Said M Afify, Akimasa Seno, Masaharu Seno7. Abnormal glycosylation in cancer cells and cancer stem cells as a thera-peutic targetby Sabina Quader, Shihori Tanabe, Horacio Cabral
£98.99
Springer International Publishing AG Biomedical Visualisation: Volume 14 ‒ COVID-19
Book SynopsisThis book focuses on the challenges to biomedical education posed by the lockdowns and restrictions to on campus teaching brought about by the COVID-19 pandemic and highlights the tools and digital visualization technologies that have been successfully developed and used for remote teaching. Biomedical education for science, medical, dental and allied health professionals relies on teaching visual and tactile knowledge using practice-based approaches. This has been delivered for decades via on-campus lectures, workshops and laboratories, teaching practical skills as well as fundamental knowledge and understanding. However, the arrival of the COVID-19 pandemic meant that education across the globe had to pivot very quickly to be able to deliver these skills and knowledge in a predominantly online environment. This brought with it many challenges, as Higher Education staff, had to adapt to deliver these visual subjects remotely. This book addresses the challenges and solutions faced by Higher Education staff in teaching visual content in distance education. Chapters include literature reviews, original research, and pedagogical reflections for a wide range of biomedical subjects, degrees such as medicine, dentistry and veterinary sciences with examples from undergraduate and postgraduate settings. The goal of the book is to provide a compendium of expertise based on evidence gathered during the COVID-19 pandemic, as well as reflections on the challenges and lessons learned from this dramatic shift in teaching. It also presents new examples of best practices that have emerged from this experience to ensure that they are not lost as we return to on-campus learning in a new era of biomedical teaching. This book will be of interest to anyone looking for a helpful reference point when designing online or blended teaching for visual practice-based subjects.Table of Contents
£116.99
Springer International Publishing AG Teaching Biostatistics in Medicine and Allied
Book SynopsisThis book discusses the theory and practice of teaching biostatistics to students in the life sciences, in particular medical and dental trainees and researchers, as well as its crucial importance to biomedical research and evidence-based health care. Specific tools and resources to biostatistics teaching (e.g., “R shiny”) are described, and how they can be used effectively to increase interaction with students and improve engagement with the subject. The book is structured into three parts: teaching and learning of statistics in medicine and allied health sciences; the move to online learning and online learning methods, especially in light of the impact of COVID-19; and computer tools and resources. It provides a unique insight into teaching biostatistics to medical and dental students from some of the most prominent biostatisticians who also have a very strong interest in biostatistics pedagogy. Biostatistics teaching is important for maintaining the quality of biomedical research and also in evidence-based medicine, both of which are key to the health and well-being of the world population. This book is particularly useful to readers who are new to the field of biostatistics teaching as well as to more experienced teachers as it presents the latest accounts of the teaching and learning of biostatistics, recent experiences of increased use of online teaching, and useful computer resources and tools for teaching biostatistics.Table of Contents1. A Survey of Biostatistics Teaching in Medicine and Dentistry in Higher Education in the UK2. Evidence-based practice teaching for undergraduate dental students3. Teaching Medical Statistics within the context of Evidence Based Medicine4. Teaching Null Hypothesis Significance Testing (NHST) in the Health Sciences: The Significance of Significance5. Teaching conceptual understanding of p-values and of confidence intervals, whilst steering away from common misinterpretations 6. Using directed acyclic graphs (DAGs) to represent the data generating mechanisms of disease and healthcare pathways: a guide for educators, students, practitioners and researchers7. Statistics without maths: using Random Sampling to teach Hypothesis Testing.8. COVID-19: Online not distant – MSc students’ feedback on an alternative approach to teaching ‘Research Methods and Introduction to Statistics’ at UCL Queen Square Institute of Neurology.9. Common misconceptions of online statistics teaching 10. Authentic project-based assessment using the Islands: Instructor’s view. 11. An interactive application demonstrating frequentist and Bayesian inferential frame-works12. Teaching data analysis to life scientists using “R” statistical software: challenges, opportunities, and effective methods13. Statistics in a world without science14. Killing me softly with your stats teaching: How much stats is too much stats?15. Life as a medical statistician.
£94.99
Springer International Publishing AG Systems Biology: Functional Strategies of Living
Book SynopsisThis open-access textbook is an excellent introduction to systems biology, which has developed rapidly in recent years. It discusses the processes in living organisms in an integrated way, enabling the reader to understand the fundamental principles and cause-effect relationships in biology and biochemistry. The authors have chosen an original but at the same time clear way of presenting the topics, repeatedly drawing comparisons and models from the macroscopic world and making the reader aware of the unity of the laws of physics, chemistry and biology. The fully updated 2nd edition also contains information that has only become available as a result of the increase in knowledge in recent years. This includes information on tumorigenesis, where significant progress has been made due to the explosive development of genetic knowledge as well as bioengineering with a highly effective technique adopted from the solutions of the bacterial world, such as CRISPR/CAS. This richly illustrated book is essential for postgraduate students and scientists of the following disciplines: biology, biotechnology, medicine, bioinformatics, robotics and automation, biocybernetics, and biomedical engineering. It is also an exciting read for anyone interested in biology. Table of ContentsSee attachments
£33.24
Springer International Publishing AG Biology of Women’s Heart Health
Book SynopsisCardiovascular disease (CVD) is the leading cause of morbidity and mortality in women and men worldwide and represents a major financial burden to world health care systems. Importantly, CVD has eclipsed cancer as the leading cause of death for women globally. Through advancements in research and clinical testing, the symptoms and risk factors for CVD have been well established for men, but not for women. Consequently, there is an immediate need for new innovative research that will bridge this gap and allow for improved early diagnosis and treatment of CVD in women. This book will serve as a guide for health care providers to better understand the physiological, biochemical, and genetic differences in heart disease in women with the goal of providing improved education, awareness and treatment of cardiovascular disease in women. The book will cover topics such as: sex dependent clinical outcomes of cardiovascular disease, cardiac protection by estrogen, cardiac health during menopause, cardiac rehabilitation programs, fitness and exercise, cardio-oncology, shift work and the CVD risk, and pregnancy related CVD.Table of Contents1. Lorrie KirshenbaumInstitute of Cardiovascular Sciences, Departments of Physiology and Pathophysiology, and Pharmacology and Therapeutics, University of Manitoba Winnipeg, Manitoba, CanadaEmail: LKirshenbaum@sbrc.ca Title: Attenuation of Bnip3 Mediated Doxorubicin-Induced Cell Death in Cardiac Myocytes2. Inna Rabinovich-NikitinInstitute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, University of ManitobaWinnipeg, Manitoba, CanadaEmail: IRabinovich-Nikitin@sbrc.ca Title: Sex Dependent Regulation of Circadian Rhythms in Health and Disease3. Tami MartinoOntario Veterinary College, Centre for Cardiovascular Investigations, Guelph University Guelph, Ontario, CanadaEmail: tmartino@uoguelph.ca Title: Circadian Pharmacological Approach to Treat Myocardial Infarct4. Ross FeldmanInstitute of Cardiovascular Sciences, St. Boniface HospitalWinnipeg, Manitoba, CanadaEmail: RFeldman@sbrc.ca Title: GPER Function as a Determinant of the Progression of Atherosclerotic Disease in Women5. Paula HarveyDepartment of Medicine, Women’s College HospitalToronto, Ontario, CanadaEmail: paula.harvey@wchospital.ca Title: Novel Therapeutic Approach to Treat Cardiac-Rheumatology in Females6. Moira K. KapralDepartment of Medicine and Institute of Health Policy, Management and Evaluation, University Health Network and Toronto General HospitalToronto, Ontario, CanadaEmail: moira.kapral@uhn.ca Title: Correlation between Sex, Immigration Status, Ethnicity, and Long-term Outcomes of Ischemic Stroke7. Jodi EdwardsSchool of Epidemiology and Public Health, University of Ottawa Heart InstituteOttawa, Ontario, CanadaEmail: jedwards@ottawaheart.ca Title: Risk Assessment and Predictive Modelling for The Heart-Brain Interface in Women8. Heather TullochDepartment of Medicine, Faculty of Medicine, University of Ottawa Heart Institute Ottawa, Ontario, CanadaEmail: hetulloch@ottawaheart.ca Title: Insomnia Interventions for Female Cardiac Patients9. Maurice Enriquez-SaranoAmerican College of Cardiology, Mayo ClinicRochester, Minnesota, United StatesEmail: sarano.maurice@mayo.edu Title: Aortic Stenosis Progression, Cardiac Damage, and Survival: Comparison Between Men and Women10. Anita AsgarMontreal Heart Institute, Universite de MontrealMontreal, Québec, CanadaEmail: anita.asgar@umontreal.ca Title: Treatment and Management of Valvular Heart Disease and Cost-Effectiveness Analysis11. Maral OuzounianPeter Munk Cardiac Centre, University Health NetworkToronto, Ontario, CanadaEmail: maral.ouzounian@uhn.ca Title: Association of Mortality and Acute Aortic Events with Ascending Aortic Aneurysm12. Sharonne HayesDepartment of Cardiovascular Medicine, Mayo ClinicRochester, Minnesota, United StatesEmail: hayes.sharonne@mayo.edu Title: Improving Diagnosis and Treatment for Patients Who Suffer Spontaneous Coronary Artery Dissection (SCAD)13. Mamas A. MamasInstitute for Primary Care and Health Sciences, Keele UniversityKeele, EnglandEmail: m.mamas@keele.ac.uk Title: Preeclampsia and Future Cardiovascular Health14. Kara NerenbergDepartment of Medicine, University of CalgaryCalgary, Alberta, CanadaEmail: kara.nerenberg@ucalgary.ca Title: Cardiovascular Disease in Women with a History of Pregnancy Complications15. Michele TurekDepartment of Medicine, Cumming School of Medicine, University of Ottawa Heart Institute and The Ottawa HospitalOttawa, Ontario, CanadaEmail: mturek@ottawaheart.ca Title: Hormone Replacement Treatment for Cardiovascular Disease16. Husam Abdel-QadirDepartment of Medicine, Women’s College Hospital and University Health Network Toronto, Ontario, CanadaEmail: husam.abdel-qadir@wchospital.ca Title: Cardiovascular Mortality Following Early-Stage Breast Cancer17. Erin MichosCiccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of MedicineBaltimore, Maryland, United StatesEmail: edonnel1@jhmi.edu Title: Lipid Management for the Prevention of Atherosclerotic Cardiovascular Disease in Women18. Tracey J.F. ColellaKITE Research Institute, University Health NetworkToronto, Ontario, CanadaEmail: tracey.colella@uhn.ca Title: Sex Differences in Cardiac Rehabilitation Enrollment19. Robert ReidDepartment of Obstetrics and Gynaecology, University of Ottawa Heart InstituteOttawa, Ontario, CanadaEmail: breid@ottawaheart.ca Title: Promoting Exercise and Physical Activity in Female Patients with Heart Disease20. Karin H. HumphriesCentre for Improved Cardiovascular Health, University of British ColumbiaVancouver, British Columbia, CanadaEmail: khumphries@icvhealth.ubc.ca Title: Sex and Gender Differences in the Diagnosis, Treatment, and Outcomes of Coronary Artery Disease21. Thais CoutinhoCanadian Women's Heart Health Centre, University of Ottawa Heart InstituteOttawa, Ontario, CanadaEmail: tcoutinho@ottawaheart.caTitle: Sex Differences in Arterial Aging and its Implications on Cardiovascular Diseases22. Amy West PollakCardiovascular Medicine, Mayo Clinic Jacksonville, Florida, United StatesEmail: pollak.amy@mayo.eduTitle: Impact of a Novel Community-Based Lifestyle Intervention Program on Type 2 Diabetes and Cardiovascular Risk23. Lisa MielniczukDivision of Cardiology, University of Ottawa Heart InstituteOttawa, Ontario, CanadaEmail: lmielniczuk@ottawaheart.ca Title: Clinical Outcomes Related to Heart Failure and Pulmonary Hypertension24. Colleen NorrisFaculty of Nursing, University of AlbertaEdmonton, Alberta, CanadaEmail: colleen.norris@ualberta.ca Title: Examination of Health-Related Quality of Life in Women with Coronary Artery Disease25. Krystina B. LewisFaculty of Health Sciences, University of OttawaOttawa, Ontario, CanadaEmail: klewi3@uottawa.ca Title: The Risks and Benefits of Implantable Cardioverter-Defibrillator Generator Replacement26. Beth L. AbramsonDivision of Cardiology, St. Michael's Hospital and University of TorontoToronto, Ontario, CanadaEmail: abramsonb@smh.ca Title: The Effects and Roles of Estrogen in Managing Hypertension in Menopausal Women27. Sharon L. MulvaghDepartment of Cardiovascular Medicine, Mayo ClinicRochester, Minnesota, United StatesEmail: smulvagh@mayo.edu Title: The Effects of Menopausal Hormone Therapy on the Vascular System28. Tara L. SedlakLeslie Diamond Women's Heart Center, Vancouver General, St. Paul’s, and UBC Hospitals, Vancouver, British Columbia, CanadaEmail: Tara.Sedlak@vch.ca Title: Influence of Sex Differences in Non-Obstructive Coronary Artery Disease29. Karen ReueDepartment of Human Genetics, University of California at Los Angeles (UCLA)Los Angeles, California, United StatesEmail: reuek@ucla.eduTitle: Diet1 and Resistance to High Cholesterol Levels and Cardiovascular Disease30. Harriette G.C. Van SpallDepartment of Medicine and Department of Health Research Methods, McMaster UniversityHamilton, Ontario, CanadaEmail: harriette.vanspall@phri.ca Title: Interventions to Improve Clinical Outcomes Following Hospitalization for Heart Failure31. Shelley ZierothInstitute of Cardiovascular Sciences, Institute of Cardiovascular SciencesWinnipeg, Manitoba, CanadaEmail: SZieroth@sbgh.mb.ca Title: Sex-Dependent Cardioprotective Effects of the Phytoestrogen Resveratrol32. Mary Norine WalshHeart Failure and Cardiac Transplantation Program, St. Vincent Heart Centre, Indianapolis, Indiana, United StatesEmail: macwalsh@iquest.net Title: Blood Pressure Across a Woman's Life Cycle33. Martha GulatiDepartment of Medicine, College of Medicine - Phoenix and the University of Arizona Phoenix, Arizona, United StatesEmail: marthagulati@email.arizona.edu Title: Women’s Fitness Levels and Heart Rate Response to Exercise34. Paul OhCardiovascular Prevention and Rehabilitation Program, University Health Network Toronto, Ontario, CanadaEmail: paul.oh@uhn.ca Title: Supervised Exercise Therapy Through Cardiac Rehabilitation following Peripheral Arterial Disease35. Delphine BaetzCarMeN Laboratory, Claude Bernard University Lyon 1Lyon, FranceEmail: delphine.baetz@univ-lyon1.frTitle: Sex Differences in ANT2-Mediated ATP Import into Mitochondria for Protection Against Hypoxia Lethal Injury
£151.99
Springer Sustainable Nanocomposites with Green
Book SynopsisChapter 1. Bioinspired green biomaterials for advanced therapeutics, diagnostics and biosensors.- Chapter 2. Sustainable nanocomposites with green biomaterials: Synthesis, properties, and applications.- Chapter 3. Biomaterials for Tissue Engineered Cartilage Product for Orthopedic (osteoarthritis) Reconstruction .- Chapter 4. Bioresorbable Polymeric Scaffold: Advancing minimally invasive surgical procedure for Cardiovascular and its applications.- Chapter 5. Plant-derived biomaterial and their use in cardiac tissue repair.- Chapter 6. Conductive Polymers and Hydrogels for Brain-Computer Interfaces.- Chapter 7. Green biopolymers as carriers for innovative drug delivery.- Chapter 8. Selective bioadsorption of gold and platinum by varying the amount of dead biomass of aspergillus niger in binary aqueous systems.- Chapter 9. Terpenes: Nature's Plasticizers for Sustainable Biopolymer Enhancement.- Chapter 10. Tailore-made sustainable nanocomposites for injection moulding and fused granulate fabrication.- Chapter 11. Advancing Eco-Friendly Biomedicine: Sustainable Nanocomposites as Platforms for Genetic Vaccines.- Chapter 12. Biodegradable materials for customized medical devices improve personalized medicine.- Chapter 13. Antimicrobial Biomaterial for Dental Healthcare Application.- Chapter 14. Recent Trends in Polyhydroxyalkanoates: Bridging the Gap Between Bench and Bedside.- Chapter 15. Attractive potential of alginate-based oil-in-water emulsion Liquid Marbles for the promising carrier of the controlled release of limonene.- Chapter 16. Suitability of 3D-printed cellulose-based polymer materials for electrical insulation applications.- Chapter 17. Advances in Green Biomaterials for Biomedical Implants and Tissue Engineering.
£132.99
Springer Python Essentials for Biomedical Data Analysis An Introductory Textbook
Book SynopsisChapter 1. Introduction to Python.- Chapter 2. Python Basics.- Chapter 3. Working with Biomedical Data – Basic Data Handling.- Chapter 4. Biomedical Data Preprocessing.- Chapter 5. Basic Biomedical Data Exploration Techniques.- Chapter 6. Data Visualization in Biomedicine.- Chapter 7. Statistical Analysis in Biomedicine.- Chapter 8. Machine Learning in Biomedicine.- Chapter 9. Image Processing in Biomedical Research.- Chapter 10. Genomic Data Analysis.- Chapter 11. Pharmacokinetics and Pharmacodynamics Analysis.- Chapter 12. Natural Language Processing (NLP) Basics.- Chapter 13. Single-cell RNA Sequencing Data Analysis.
£67.05
Springer Sustainable biopolymers and composites for
Book SynopsisChapter 1. Letter from the Editors: Sustainable Biopolymers and Composites for Biomedical Applications.- Chapter 2. Current Trends in Sustainable Biopolymers for Biomedical Engineering and Pharmaceutical Applications.- Chapter 3. Green Synthesis of Sustainable Materials from Biomass for Bioengineering.- Chapter 4. Sustainable Materials for Tissue Engineering. - Chapter 5. Advancements in Lignin-Based Binders in Medical Application: From Extraction to Applications.- Chapter 6. Polysaccharide-Based Encapsulation of Active Ingredients for Biomedical Applications: From Macroscale to Nanoscale.- Chapter 7. Lignin Chemistry and Functionalization for Potential Medical Applications.- Chapter 8. Lignin as an Emerging Sustainable Biosensing Platform for Medical Applications.- Chapter 9. Lignin Composites for Biomedical Applications.- Chapter 10. Lignin Hybrid Materials and Blends for Biomedical Applications – A life cycle analysis.- Chapter 11. Lignin Based Nanomaterials for Potential Biomedical Applications.- Chapter 12. Lignin Based Nanocomposites for Biomedical Applications.- Chapter 13. Lignin as a Drug Encapsulant.- Chapter 14. Lignin-based Hydrogels for Pharmaceutical and Biomedical Applications.- Chapter 15. Sustainable carbon fibres and Piezoelectric Sensors for Possible Integration in Future Biomedical Devices.- Chapter 16. Three-Dimensional Printing of Lignin-Based Materials.- Chapter 17. Lignin Based Energy Materials for Biomedical Applications.- Chapter 18. Bioinspired Corona Nanomaterials for Point-of-care Testing Sensors and Drug Delivery Systems.- Chapter 19. Sustainable Marine-based Biopolymers and Biocomposites for Advanced Biomedical Applications.
£134.99
Springer Biomaterialbased Additive Manufacturing in Tissue Engineering and Regeneration
Book SynopsisChapter 1. Introduction to biomaterials in design of regenerative medicine - Amol D Gholap, Nitin K Sen, Prashant J Shinde, Prakash D Khandagale and Sagar Pardeshi.- Chapter 2. Biomaterials for regenerative medicine: Historical perspectives and current trends - Ayush Madan, Abhik Paul, Krishnendu Adhikary, Anas Islam, Sumel Ashique, Radheshyam Pal, Masoumeh Bagheri and Naheed Mojgani.- Chapter 3.- Overview of additive manufacturing for tissue engineering and regeneration - Safiya Mohammed Saeed, Samiha Binte Sadiq, Rehnuma Binta Hafiz, Jahida Yeasmin, Farjana Yesmin, Amol D. Gholap and Md Jasim Uddin.- Chapter 4.- Advances in additive manufacturing in tissue engineering and regeneration - Yogesh V Ushir, Akanksha M Kamble, Sudarshan Singh and Shekhar Kokate.- Chapter 5. Advanced smart biomaterials and constructs for hard tissue engineering and regeneration through additive manufacturing - Amol D Gholap, Pankaj R. Khuspe, Swapnil A. Phade, Dipali V. Mane, Navnath T. Hatvate, Abhijeet V. Puri and Satish Rojekar.- Chapter 6. Biomaterials-based additive manufactured scaffolds for tissue engineering and regenerative medicine - Viola Colaco, Sony Priyanka Bandi, Namdev Dhas, Prabhanjan S. Giram and Deepanjan Datta.- Chapter 7. Natural polymer-based additive manufactured product for tissue engineering and regenerative medicine - Bahareh Alizadeh, Shreya Shashank Chauhan, Sony Priyanka Bandi and Deepanjan Datta.- Chapter 8. Synthetic polymer-based additive manufactured goods for regenerative medicine and tissue engineering - Pooja Bhane, Rachana Hajare, Vishal Pande and Sachin Kothawade.- Chapter 9. Biomaterials-based additive manufactured products for chronic wound healing - Popat Mohite, Abhijeet Puri, Ramdas Pandhare, Sudarshan Singh, Manisha Sonawane and Anil Pawar.- Chapter 10. Biomaterials-based additive manufactured products for diabetic wound healing - Popat Mohite, Sudarshan Singh, Yogesh Chaudhari, Manisha Chaudhari, Yunus Ansari, Amol Gholap and Abhijeet Puri.- Chapter 11. Biomaterials-based additive manufactured products for in situ tissue engineering - Yash Tarwate, Akshay Khandke, Madhur Kulkarni, Kunal Banode Mital Patel, Krutika Pardeshi and Amarjitsing Rajput.- Chapter 12. Biomaterials-based additive manufacturing of veterinary products - Himanshu Paliwal, K. Prem Ananth and Pijush Kumar Paul - Chapter 13. Hydrogel-based strategies: tailoring biomaterial properties for additive manufacturing in tissue regeneration - Himanshu Paliwal, K. Prem Ananth and Pijush Kumar Paul.- Chapter 14. Innovative bioengineering solutions for otolaryngology management: customized additive manufacturing with biomaterials - Rajdip Goswami, Subhajit Das, Sourav Ghosh, Swarupananda Mukherjee, Sudarshan Singh and Biswajit Basu.- Chapter 15. Biomaterials-based additive manufactured constructs for drug testing - Helen Jalaja Shibu, Hega Vincent, Anugya Bhatt, Naresh Kasoju and Renjith P Nair.- Chapter 16. Challenges and future directions biomaterial-based additive manufacturing in tissue engineering and regeneration - Pankaj R. Khuspe, Dipali V. Mane, Vishal Galave, Audumbar Mali, Popat B, Mohite, Abhijeet V Puri, Md. Jasim Uddin and Amol Gholap.- Chapter 17. Regulatory aspects, future prospects, and challenges associated with biomaterials-based additive manufacturing for tissue engineering - Abhijeet Puri, Amol D. Gholap, Yogesh Chaudhari, Pooja V Nagime, Sudarshan Singh and Popat Mohite.
£107.99
£107.99
Springer-Verlag GmbH Nanocrystals in Cancer Theranostics
£37.39
De Gruyter Biomechanics of Dance: Applications of Classical
Book SynopsisThis book provides a detailed analysis of human movement, building from simple physical models to more complex analyses and biomechanical models, including forces internal to the body. The book integrates principles of Physics with the functioning of the nervous and musculoskeletal systems to understand how movement in general, and dance movements specifically, can be executed to enhance performance and reduce injury risk.
£69.75
Thieme Publishing Group The Coordination of Clinical Research
Book SynopsisA novel and indispensable handbook for clinical research coordinators worldwideBecause saying isn''t doing; doing is doing: This fourth volume in Mohit Bhandari''s series of methodology books, conceived as a transformational guide to executing research for those who coordinate it on a daily basis, focuses not on the design of research projects, but rather on the actual execution of such projects.Key Features: International group of authors and practicing research coordinators with decades of collective hands-on experience Includes many crucial, but often neglected, topics such as principles of successful grant writing, working with study budgets, ethics and consent forms, regulatory versus standard trials, coordinating and conducting observational research and randomized clinical trials, and much more Many helpful templates and sample forms with checklists, consent forms, budget outlines, and more
£999.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Biophilosophy: Analytic and Holistic Perspectives
Book SynopsisThis book is an introduction to biophilosophy, written primarily for the student of biology, the practicing biologist, and the educated layperson. It does not presuppose technical knowledge in biology or philosophy. However, it requires a willingness to examine the most basic foundations of biology which are so often taken for granted. Furthermore, it points to the bottomlessness of these foundations, the mystery of life, the Unnamable .,. I have tried to further the awareness that biological statements are based on philosophical assumptions which are present in our minds even before we enter the laboratory. These assumptions, which often harbor strong commitments, are exposed throughout the book. I have tried to show how they influence concrete biolog ical research as well as our personal existence and society. Thus, emphasis is placed on the connection between biophilosophy and biological research on the one hand, and biophilosophy and the human condition on the other.Table of Contents- On the importance of Biophilosophy; Definitions.- 1 Theories and Hypotheses.- 1.1 Introduction - Questions and problems.- 1.2 The Aim of Science - General and singular propositions. Theories, laws, rules, hypotheses, auxiliary hypotheses, ad hoc hypotheses, working hypotheses, models, facts.- 1.3 Scientific Methodology or How We Gain Scientific Knowledge.- 1.3.1 General Considerations - Importance of methodology. Laboratory methodology.- 1.3.2 Induction and the Hypothetico-deductive Method.- 1.3.3 Validation of Hypotheses, or: Is Certainty Attainable?.- 1.3.3.1 The First Postulate of Validation - Hypotheses may be proved (justificationism). Criticism.- 1.3.3.2 The Second Postulate of Validation - Hypotheses cannot be proved, but may be disproved (falsified) (falsificationism). Criticism.- 1.3.3.3 The Third Postulate of Validation - Hypotheses can neither be proved, nor disproved; they may only be either confirmed or disconfirmed. Internal and external factors of science.- 1.3.4 A Systems Model of Scientific Methodology (Laszlo’s Model) - Empirical input, ideals (values) of science, and the relation of resistance factors to innovation. Irrationally in science. Demarcation of science.- 1.4 Is Scientific Progress Possible? - Incommensurability. Progress within paradigms. Coexistence of schools of thought. Unity of science. Complementarity and perspectivism.- 1.5 The Semantic View of Theories.- 1.6 Conclusions.- 1.7 Summary.- 2 Laws, Explanation, Prediction, and Understanding.- 2.1 Laws - Definition. Deterministic and probalistic laws. Accidental generalizations. Process and coexistence laws. Law and order versus chaos: is nature lawful?.- 2.2 Explanation - Two basic requirements for scientific explanation. Deductive-nomological explanation. Probabilistic explanation. Covering-law model of explanation versus narrative explanation. Other notions of explanation.- 2.3 Prediction - Characterization. Comparison of prediction and explanation. Predictive power and its limitations.- 2.4 Understanding - Understanding and explanation.- 2.5 Summary.- 3 Facts.- 3.1 Introduction - Facts as singular propositions.- 3.2 First Definition of ‘Fact’ : A proposition of a real particularity. Criticism of naive realism.- 3.3 Second Definition of ‘Fact’ : A proposition of an objective datum of perception. Perceiving and sensing. Primary realm. Culture- and theory-dependence of facts.- 3.4 Objectivity - Two definitions. Relativity and culture-dependence of objectivity. States of consciousness.- 3.5 Facts and Reality - ‘Datum’ (‘donné’),‘observation’, ‘factum’ (‘fait’; ‘Tatsache’). Absolute and moderate relativism. Criticism of absolute relativism. Patterned continuum.- 3.6 Experience - Perceiving, sensing, and experience as being (Zen).- 3.7 Summary.- 4 Concepts and Classification.- 4.1 Concepts.- 4.1.1 Introduction - Concepts as abstractions. Abstraction as selection. Examples.- 4.1.2 Nominalism Versus Realism - Controversy over universals.- 4.1.3 Degree of Adequacy of Concepts - Woodger’s map analogy. Restriction of map analogy. Examples. Complementarity.- 4.1.4 Limits of Concepts - Intension and extension of concepts. Meaninglessness. Example.- 4.1.5 Classification of Concepts - Qualitative, comparative, and quantitative concepts. Individual, class, relation, and quantitative concepts.- 4.1.6 Term, Concept, and Reality - Three level scheme.- 4.1.7 Definition - Importance of definition. Primitive terms.- 4.1.8 Operationism - Advantages and disadvantages.- 4.1.9 Are There Biological Kinds of Concepts? - Historical, functional, and polytypic (= polythetic) concepts. Significance of polytypic concepts. Fuzzy sets. Injunction. Types as injunctions.- 4.1.10 Fundamental Conclusions and Consequences - Fragmentation and wholeness (unity).- 4.2 Classification.- 4.2.1 Classes - Definitions of taxonomy and systematics. Class concepts. Species concepts. The biological species as an individual.- 4.2.2 Systems of Classification - Three steps in the construction of systems. Sameness. Qualitative, comparative (= semiquantitative) and quantitative homology. Weighting of characters. Phenetic versus phylogenetic systems. Are there natural systems? Complementarity. Hierarchical systems versus nets. Classifying versus ordering. Social and existential relevancy of classification and order.- 4.3 Summary.- 5 Comparative Plant Morphology: A Biophilosophical Case Study - An illustration and discussion of the major concepts dealt with in Chapters 1 to 4.- 6 Causality, Determinism, and Free Will.- 6.1 Causality.- 6.1.1 Introduction - Controversy over causality. Plato, Aristotle, Hume, Kant, Comte, Russell, Wittgentein, Collingwood, and Bunge on causality.- 6.1.2 Linear Causality - Causal chains, simple and branched (= hierarchical).- 6.1.3 Circular Causality - Feedback loops.- 6.1.4 Network Causality - Linear and circular causality as special cases of network causality. Network thinking. Wholeness.- 6.1.5 Mohr’s Model of Factor Analysis - Relation of causal analysis and factor analysis. Examples.- 6.1.6 Consequences of Network Thinking - Integration and systems thinking in science, society and our personal life. Relation of “cause” and “guilt”. Fire-walkers and kavadi bearers.- 6.1.7 Network Thinking in Medicine - Cancer; Myopia.- 6.2 Causalism - Two formulations of the principle of causality. Spontaneity and chance.- 6.3 Determinism - Definition. Indeterminism s. str. Methodological and ontological interpretations of Heisenberg’s uncertainty principle. Determinism s. lat. Four types of determination. Indeterminism s. lat. Order and chaos.- 6.4 Free Will - Rejection of free will. Defense of free will through scientific argumentation or existential experience (Jaspers).- 6.5 Beyond Free Will - Schrödinger’s mystical solution of the apparent contradiction between determination and the experience of free will.- 6.6 Summary.- 7 Teleology.- 7.1 Introduction - Purpose and function. Semantic confusion and complexity of phenomena.- 7.2 Terminology - Four definitions of teleology. Teleonomy. External and internal teleology. Teleology of unique events. Purposiveness. Six definitions of function. Adapted systems. Finality.- 7.3 Goal-intendedness - Mohr’s model of human teleology. Relaxations of Mohr’s model applied to animals and plants. Degrees of consciousness. Do plants have emotions and consciousness?.- 7.4 Goal-directedness - Genetic “programs” are open. Cybernetics and its application to ontogeny and phylogeny. Integration.- 7.5 Function - Two meanings of function and their consequences: function as necessary for survival, and function as any activity that relates to the system. Functionality as complementary to causality. Network functionality and network causality. Linear functionality and linear causality. Can functional statements be reduced to causal ones? Integration and function.- 7.6 Teleology and Reality - Adequacy of teleological and teleonomic concepts. No ends and no purpose in nature. Functions as an aspect of nature, but not inherently natural. No-purpose. Going nowhere.- 7.7 Summary.- 8 Evolution and Change.- 8.1 Introduction - Basic kinds of questions in biology.- 8.2 Universality of Change - Everything flows. Slow and rapid changes. Catastrophes. Change of laws. Dynamism in other cultures.- 8.3 Historicity - Problems of historical science: prediction, explanation, and uniqueness.- 8.4 Evolution and Progress - Definitions of “evolution” and “progress”. Criticism of the idea of general progress and superiority.- 8.5 Modern Evolutionary Theory.- 8.5.1 Three Aspects of Evolutionary Theory.- 8.5.2 Chance and Necessity - External and internal selection. Systems theory of evolution.- 8.5.3 The Status of Evolutionary Theory and Tautology.- 8.6 Evolutionary Epistemology - Seven problems and Riedl’s solutions. Criticism of Riedl’s assumptions, postulates, and basic concepts. Merits of evolutionary epistemology.- 8.7 Evolutionary Theory and Human Values - Feedback between science and human values. Values underlying Darwinism, neo-Darwinism, and sociobiology. Alternative values. Pluralism. Deconstruction.- 8.8 Summary.- 9 What is Life?.- 9.1 Introduction - Ways of defining life.- 9.2 Vitalism - Animism. Vital principle. H. Driesch. Four criticism of vitalism.- 9.3 Mechanism - Four meanings of mechanism.- 9.4 Reductionism - Two kinds of mechanism in reductionist terms. Three kinds of reduction: ontological, epistemological and methodological. Emergence. No-thingness. Derivability and connectability. Replacement instead of reduction. Perspectivism. Compositionism.- 9.5 Machine Theory of Life - Two meanings. The computational metaphor.- 9.6 Organicism - Organizing relations. Directiveness. Historicity. Autonomy of biological theory.- 9.7 What is Life? - Monotypic, polytypic, and “fuzzy” definitions. Limitations of definitions. Life as direct experience. Oneness.- 9.8 The Mind-Body Problem - Statement of the problem. Several different approaches.- 9.9 Summary.- 10 World Hypotheses (World Views) and Truth.- 10.1 Introduction - The relevance of world hypotheses (world views).- 10.2 Pepper’s Seven World Hypotheses.- 10.2.1 Formism.- 10.2.2 Mechanism.- 10.2.3 Contextualism.- 10.2.4 Organicism.- 10.2.5 Modern Biology in Relation to the Above Four World Hypotheses.- 10.2.6 The Generating-substance Hypothesis.- 10.2.7 Animism.- 10.2.8 Mysticism.- 10.3 Truth.- 10.4 Summary.- Epilogue: On the Importance of Living.- References.
£42.74
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Glycoscience: Chemistry and Chemical Biology
Book SynopsisAs a reflection of the quantum leap that has been made in the study of glycostructures, the first edition of this book has been completely revised and updated. The editors give up-to-date information on glycostructures, their chemistry and chemical biology in the form of a completely comprehensive survey. Glycostructures play highly diverse and crucial roles in a myriad of organisms and important systems in biology, physiology, medicine, bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and the chemistry behind them. While many facts remain undiscovered, this MRW has been contributed to by a large number of the world’s leading researchers in the field.Table of Contents1 General Principles.- 1.1 Structure and Conformation of Carbohydrates.- 1.2 General Occurance and Properties of Carbohydrates.- 2 General Synthetic Methods.- 2.1 Reactions at Oxygen Atoms.- 2.2 Oxidation, Reduction and Deoxygenation.- 2.3 Heteroatom Exchange.- 2.4 Anhydrosugars.- 2.5 C-C Bond Formation.- 2.6 C=C Bond Formation.- 2.7 Degradations and Rearrangement Reactions.- 3 Chemical Glycosylation Reactions.- 3.1 Introduction to Glycosylation Reactions.- 3.2 Glycosyl Halides.- 3.3 Glycosyl Trichloroacid Imidates.- 3.4 Other Anomeric Esters.- 3.5 O-Glycosyl Donors.- 3.6 S-Glycosylation.- 3.7 Glycal Derivatives.- 3.8 Anomeric Anhydro Sugars.- 3.9 C-Glycosylation.- 4 Monosaccharides.- 4.1 Occurance, Significance and Properties.- 4.2 Monosaccharides and Polyols in Foods.- 4.3 De Novo Synthesis of Monosaccharides.- 4.4 Monosaccharides as Chiral Pools for the Synthesis of Complex Natural Compounds.- 4.5 Monosaccharides as Scaffolds for the Synthesis of Novel Compounds.- 4.6 Monosaccharides as Chiral Auxiliaries and Ligands for Asymmetric Synthesis.- 4.7 Carbohydrate Metal Complexes.- 5 Oligosaccharides.- 5.1 Occurrence, Significance and Properties.- 5.2 Sucrose and Related Oligosaccharides.- 5.3 Oligosaccharides in Food and Agriculture.- 5.4 Combinatorial Methods in Oligosaccharide Synthesis.- 5.5 Solid Phase Methods.- 5.6 Stereoselective Synthesis of ß-Manno Glycoside.- 5.7 Silalylation.- 5.8 Enzymatic Glycosylation by Tranferases.- 5.9 Enzymatic Glycosylation by Hydrolases.- 6 Complex Polysaccharides.- 6.1 Occurence, Significance and Properties.- 6.2 Starch.- 6.3 Cellulose and Hemicellulose.- 6.4 Gums and Related Polysaccharides.- 6.5 Bacterial Cell Wall Components.- 6.6 Fungal Cell Wall Components.- 6.7 Structure-Activity Relationship of Glycosaminoglycans.- 7 Glycolipids.- 7.1 Occurence, Significance and Properties.- 7.2 Synthesis.- 7.3 Biosynthesis and Degradation.- 7.4 Glycosylphosphatidylinositols.- 8 Glycoproteins.- 8.1 Occurence and Significance.- 8.2 Properties.- 8.3 Synthesis and Applications of Biologically Relevant Glycopeptides and Glycoproteins.- 8.4 Glycosilylation Engineering of Glycoproteins.- 8.5 Glycoprotein Analysis.- 9 Glycomimetics.- 9.1 Azaglycomimetics: Synthesis and Chemical Biology.- 9.2 Carbasugars: Synthesis and Functions.- 9.3 Sulfur Containing Glycomimetics.- 9.4 C-Glycosyl Analogs of Oligosaccharides and Glycosyl Amino Acids.- 9.5 Non-Sugar Glycomimetics.- 10 Key Technologies and Tools for Functional Glycobiology.- 10.1 Introduction.- 10.2 Microarrays.- 10.3 Chemical Probes and Monitoring.- 10.4 Glycomics and Mass Spectrometry.- 10.5 Bioinformatical Tools.- 11 Biosynthesis and Degradation.- 11.1 Introduction.- 11.2 Biosynthesis and Degradation of Monosaccharides.- 11.3 Biosynthesis of Oligosaccharides and Polysaccharides.-11.4 Degradation of Oligosaccharides and Polysaccharides.- 12 Glycomedicine.- 12.1 Novel Approaches for Glycodrug Discovery.- 12.2 Biomedicine of Monosaccharides.- 12.3 Mammalian Carbohydrate-Lectin Interactions.- 12.4 Multivalency in Protein-Carbohydrate Recognition.- 12.5 Synthesis of Heparin-Fragments.- 12.6 Biomedicine of Glycolipids and Glycosphingolipids.- 12.7 Biomedicine of Enkephalin-Derived Glycopeptide Analgesics.- 12.8 Antitumor and Antimicrobial Glycoconjugates.- 12.9 Biomedicine of Glycosylated Natural Compounds.- 12.10 Mucin-based Vaccines.- 12.11 Polysaccharide-based Vaccines
£404.99
Springer Fachmedien Wiesbaden Einfache lineare Regression: Die Grundlage für
Book SynopsisDieses essential befasst sich mit der einfachen linearen Regression, der simpelsten Form von Regressionsmodellen, in der für die Modellbildung nur eine einzige Einflussvariable berücksichtigt wird. Leser finden in diesem Buch die Methode der kleinsten Quadrate zur Schätzung der Modellparameter, Residualanalysen zur Überprüfung der Modellannahmen sowie weitere statistische Verfahren zur Beurteilung des Modells. Zudem erfahren sie, wie das Modell als ein Prognoseinstrument eingesetzt werden kann. Somit erwerben Leser eine solide Grundlage zum Verständnis komplexer Regressionsansätze, bei denen mehrere Variablen die Zielgröße beeinflussen und nichtlineare Zusammenhänge vorliegen.Table of ContentsDefinition des einfachen Regressionsmodells.- Überprüfung der Modellvoraussetzungen.- Beurteilung des Modells durch den Korrelations- und den Determinationskoeffizienten.- Regressionsgerade als ein Instrument für eine Prognose.- Umkehrregression.
£11.77
Springer Fallzahlberechnung in der medizinischen
Book SynopsisMeinhard Kieser vermittelt anhand realer Beispiele die grundlegenden Prinzipien der Fallzahlberechnung und demonstriert deren Anwendung. Für die häufigsten Anwendungssituationen werden die entsprechenden Fallzahlberechnungsformeln hergeleitet. Einsteiger haben somit die Möglichkeit, die Grundlagen der Fallzahlplanung zu erlernen und einzuüben. Es werden außerdem die statistischen Hintergründe der Formeln und allgemeinere Zusammenhänge erläutert und Hinweise gegeben, was bei jeder Fallzahlberechnung beachtet werden sollte. Damit geht das essential deutlich über eine reine Formelsammlung hinaus und ist eine wertvolle Ergänzung für Personen, die bereits in der medizinischen Forschung tätig sind und Erfahrung bei der Fallzahlberechnung gesammelt haben.Table of ContentsDas Prinzip der Fallzahlberechnung.- Fallzahlberechnung für Zwei- und Mehr-Gruppen-Vergleiche bei normalverteilter und binärer Zielgröße.- Ausblick auf weitere Methoden zur Fallzahlberechnung in anderen Anwendungssituationen.- Hinweise auf Aspekte, die bei jeder Fallzahlberechnung beachtet werden sollten.
£11.77
Springer Fachmedien Wiesbaden Parametrische Statistik: Verteilungen, maximum likelihood und GLM in R
Book SynopsisBeispielreich baut dieses Buch Schritt für Schritt die statistischen Grundlagen moderner Datenanalysen auf. Im Gegensatz zu anderen einführenden Werken legt dieses Buch großen Wert auf einen umfassend gespannten Bogen, einen roten Faden, der alle Methoden zusammenführt. Dabei werden klassische statistische Methoden (etwa t-Test oder multiple Regression) als Spezialfall des Generalisierten Linearen Modells entwickelt. Entsprechend legt das Buch zunächst eine Grundlage in beschreibender Statistik, Verteilungen und maximum likelihood, aus der dann alle anderen Verfahren abgeleitet werden (ANOVA, multiple Regression). Jeder Schritt ist auf zwei Kapitel verteilt: Im ungradzahligen Kapitel wird anhand von vielen Beispielen und Abbildungen die Idee der statistischen Herangehensweise erläutert. Im sich daran anschließenden gradzahligen Kapitel wird die Umsetzung in der freien Statistiksoftware R gezeigt. Ein Kapitel zur Wissenschafts- und Forschungstheorie und eines zum Design von Experimenten und Stichprobeverfahren komplettiert dieses einleitende Werk. Das Buch legt großen Wert auf Verständlichkeit und Umsetzung. Mathematische Herleitungen treten demgegenüber stark in den Hintergrund. Jedes Kapitel enthält explizit ausgewiesene Lerninhalte, die durch Übungen zu jedem R-Kapitel geprüft werden können. Ein ausführliches Schlagwortverzeichnis inklusive der R-Funktionen macht das Buch auch als Nachschlagewerk nutzbar. Die zweite Auflage wurde ergänzt um Schätzung mittels der Momentenmethode, Residuendiagnostik für nicht-normalverteilte Daten und die erschöpfende Modellsuche.Table of ContentsStichprobenstatistik.- Stichprobenstatistiken in R.- Verteilungen, ihre Parameter und deren Schätzer.- Verteilungen, Parameter und Schätzer in R.- Korrelation und Assoziation.- Korrelation und Assoziation in R.- Regression - Teil I.- Regression in R Teil I.- Regression Teil II.- Regression in R Teil II.- Das Lineare Modell: t-Test und ANOVA.- Das Lineare Modell: t-Test und ANOVA in R.- Hypothesen und Tests.- Experimentelles Design.- Multiple Regression.- Multiple Regression in R.- Ausblick.
£28.49
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Löffler/Petrides Biochemie und Pathobiochemie
Book SynopsisJetzt kommt Bewegung in die Biochemie!Die ganze Welt der Biochemie und Pathobiochemie in 74 überschaubaren Kapiteln und über 1000 Abbildungen erklärt – da bleibt keine Frage offen.Und mehr noch, damit Sie die komplexen Vorgänge in Stoffwechsel, Signaltransduktion und Molekularbiologie schneller verstehen, sind mit der kostenlosen MoreMediaApp fast 400, teils vertonte Videos direkt aus dem Buch abrufbar – einfach das Bild mit dem Smartphone oder Tablet scannen und schon werden Citratzyklus, DNA-Replikation und Co. lebendig! So lässt sich auch später in der Klinik schnell etwas wiederholen – Film ab und das biochemische Hintergrundwissen ist aufgefrischt.Außerdem bietet die Biochemie und Pathobiochemie: 74 überschaubare Kapitel für einen guten Überblick Auflistung der Schwerpunkte am Kapitelanfang Einen Roten Faden, der kleine Abschnitte kurz zusammenfasst Zusammenfassungen am Kapitelende Tafelteil mit den wichtigsten Strukturformeln zum Nachschlagen Wie wichtig das Wissen über Moleküle, Mechanismen und Signalwege für das Verständnis pathologischer Vorgänge ist, wird anhand zahlreicher spezieller Abschnitte oder eigener Kapitel zur Pathobiochemie herausgestellt. Schließlich geben spannende Exkurse und Hintergrundinfos einen Blick über den Tellerrand oder weiter in die Tiefe.Biochemie ausführlich und animiert – Ihr Begleiter durchs ganze Studium!Table of ContentsI Grundlagen der Biochemie und Molekulären Zellbiologie: Ohne Wasser kein Leben.- Vom Molekül zum Organismus.- Kohlenhydrate, Lipide, Aminosäuren und Nucleotide - Bausteine des Lebens,mitTafelteil.- Thermodynamik und Bioenergetik.- Proteine - Struktur und Funktion.- Proteine – Analytische Untersuchungsmethoden, Synthese und Isolierung.- Enzyme - Molekulare und funktionelle Grundlagen der Biokatalyse.- Regulation der Enzymaktivität.- Enzyme in Analytik, Diagnoste und Therapie.- Nucleinsäuren - Struktur und Funktion.- Biokatalyse.- Zellorganellen und Vesikeltransport. Cytoskelett.-II Zellulärer Metabolismus: Glucose – Schlüsselmolekül des Kohlenhydratstoffwechsels.- Mechanismen der Glucosehomöostase.- Zucker - Bausteine von Glycoproteinen und Heteroglycanen.- Pathobiochemie des Kohlenhydratstoffwechsels.- Der Citratzyklus – Abbau von Acetyl-CoA zu CO2 und H2O.- Mitochondrien – Organellen der ATP-Gewinnung.- Oxidoreduktasen und reaktive Sauerstoffspezies.- Lipogenese und Lipolyse - Bildung und Verwertung der Fettspeicher.- Stoffwechsel von Phosphoglyceriden und Sphingolipiden.- Stoffwechsel von Cholesterin.- Lipoproteine - Transportformen der Lipide im Blut.- Pathobiochemie des Lipidstoffwechsels.- Prinzipien von Aminosäurestoffwechsel und Stickstoffumsatz.- Funktioneller Aminosäurestoffwechsel.- Pathobiochemie des Aminosäurestoffwechsels.- Purinnucleotide – Biosynthese, Wiederverwertung und Abbau.- Pyrimidinnucleotide – Biosynthese, Wiederverwertung und Abbau.- Pathobiochemie des Purin- und Pyrimidinstoffwechsels.- Porphyrine - Synthese und Abbau.- III Zelluläre Kommunikation: Prinzipien zellulärer Kommunikation.- Mediatoren.- Rezeptoren und ihre Signaltransduktion.- Insulin - das wichtigste anabole Hormon.- Glucagon und Katecholamine - Gegenspieler des Insulins.- Integration und hormonelle Regulation des Energiestoffwechsels.- Hormone des Hypothalamus und der Hypophyse.- Steroidhormone – Produkte von Nebennierenrinde und Keimdrüsen.- Schilddrüsenhormone – Zentrale Regulatoren von Entwicklung, Wachstum, Grundumsatz, Stoffwechsel und Zelldifferenzierung.- Wachstumshormon und Prolactin.- IV Molekularbiologie: Zellzyklus – Koordination der Zellteilung.- Replikation –Die Verdopplung der DNA.- DNA-Mutationen und ihre Reparatur.- Transkription und Prozessierung von RNA.- Regulation der Transkription – Aktivierung und Inaktivierung der Genexpression.-Translation – Synthese von Proteinen.- Proteine - Transport, Modifikation und Faltung.- Proteine – Mechanismen ihres Abbaus.- Der programmierte Zelltod - Apotose, Nektrotose, Ferroptose und Pyroptose.- Prinzipien der zellulären Tumorgenese und –progression.- Das Tumorstroma.- Gentechnik.- Gentechnik in höheren Organismen – Transgene Tiere und Gentherapie.- V Funktionelle Biochemie der Organe: Energiebilanz und Ernährungszustand.- Makronährstoffe und ihre Bedeutung.- Fettlösliche Vitamine.- Wasserlösliche Vitamine.- Spurenelemente.- Gastrointestinaltrakt.-Leber - Zentrales Stoffwechselorgan.- Quergestreifte Muskulatur.- Die glatte Muskulatur.- Niere – Ausscheidung von Wasser und Elektrolyten.- Niere – Der Säure-Basen- und Mineralhaushalt.- Blut – Zelluläre Bestandteile und Blutplasma.- Blut – Hämatopoese und Erythrocyten.- Blut – Thrombocyten und Leukocyten.- Immunologie.- Extrazelluläre Matrix - Struktur und Funktion.- Knorpel- und Knochengewebe.- Haut.- Nervensystem.- Anhang.
£66.49
Spektrum Akademischer Verlag Methoden der statistischen Inferenz: Likelihood
Book SynopsisVorwort.- 1 Einführung.- 2 Likelihood.- 3 Frequentistische Eigenschaften der Likelihood.- 4 Likelihood-Inferenz bei vektoriellem Parameter.- 5 Bayer-Inferenz.- 6 Modellwahl.- 7 Numerische Methoden zur Bayes-Inferenz.- 8 Prognose.- A Ergänzungen aus der Stochastik.- B Ergänzungen aus der linearen Algebra und Analysis.- C Ergänzungen aus der Numerik.- Literaturverzeichnis.- Index.
£31.34
Springer Biomarkers of Radiation in the Environment:
Book SynopsisThis proceedings volume results from the NATO Advanced Research Workshop on 'Biomarkers of Radiation in the Environment: Robust Tools for Risk Assessment (BRITE)’. The BRITE workshop discussed insights from cancer research, epigenetics, non-human and human risk assessment, since many of the state-of-the-art biomarkers being developed for humans deserve consideration for environmental applications and vice versa. Sessions were very wide-ranging covering methods, mechanisms, cross disciplinary application and regulation.The chapters in this book have been grouped into five major themes that were covered by the BRITE workshop:· Techniques for biomarker development· Low-dose effect mechanisms· Biomarkers for risk evaluation· Biomarkers in wildlife· Biomarker use and responses Each chapter has been written independently and reflects the views of the chapter author(s). Therefore, the readers can form their own balanced view of the different perspectives on biomarkers of radiation in the environment. Given the breadth of topics covered and the state-of-the-art perspectives shared by leading experts in their respective fields, this book should form a valuable resource for anyone with an interest in how biomarkers can be used to improve our understanding of radiation in the environment and its potential impacts.Table of ContentsTECHNIQUES FOR BIOMARKER DEVELOPMENT.- Chapter 1. Reducing Uncertainties In Live Monitoring Of Radiation In Wildlife; T. Cresswell.- Chapter 2. Synchrotron Light Facilities And Applications In Life Sciences; V.M. Tsakanov.- Chapter 3. Elemental Imaging In Biology Using Synchrotron X-Ray Fluorescence Microscopy; K. Brown.-LOW-DOSE EFFECT MECHANISMS.- Chapter 4. Modelling Direct And Indirect Effects Of Radiation: Experimental, Clinical And Environmental Implications; S.C. Brueningk, G.P. Powathil.- Chapter 5. Immune Networks In The Context Of Low Dose Ionizing Radiation; D. Schaue et al.- Chapter 6. Learning From Nato Biomarker Research For Humans; A. Giovannetti et al.- BIOMARKERS FOR RISK EVALUATION.- Chapter 7. Exosomes As Radiation Biomarkers; K.K. Jella.- Chapter 8. Monitoring Very Low Dose Radiation Damage In Dna Using “Field-Friendly” Biomarkers; K. Rothkamm, S. Burdak-Rothkamm.- Chapter 9. The Development Of Bio-Assays Based On Non-Targeted Effects Of Radiation; A Potential Worm-Hole Into Ecosystem Level Biomarkers; C. Mothersill. BIOMARKERS IN WILDLIFE.- Chapter 10. Birds As Bioindicators Of Radioactive Contamination And Its Effects; A. Bonisoli-Alquati.- Chapter 11. Amphibians In Field Radioecology: A Review And Perspective; G. Orizaola.- Chapter 12. Measuring Adaptive Responses Following Chronic And Low Dose Exposure In Amphibians; M. Audette-Stuart et al.- Chapter 13. Are There Ecosystem-Relevant Endpoints For Measuring Radiation Impacts?; C. Bradshaw.-Chapter 14. Biomarkers And Ecological Indicators For Environmental Radioactivity In Invertebrates; K. Raines et al.- BIOMARKER USE AND RESPONSES.- Chapter 15. Biomarkers Of Radiation And Risk Assessment By Ionizing Radiation, Countermeasures For Radiation Protection Of Environment, Workers And Public; L. Qafmolla.- Chapter 16. Application Of The International System Of Radiation Protection In Fit-For-Purpose Assessment Of Impacts; T.L. Yankovich.- Chapter 17. Practicalities Of Mainstreaming Biomarker Use – A Canadian Perspective; S. Mihok, M. McKee.- Index.
£143.99
