Medical research Books
Spektrum Akademischer Verlag Methoden der statistischen Inferenz: Likelihood
Book SynopsisVorwort.- 1 Einführung.- 2 Likelihood.- 3 Frequentistische Eigenschaften der Likelihood.- 4 Likelihood-Inferenz bei vektoriellem Parameter.- 5 Bayer-Inferenz.- 6 Modellwahl.- 7 Numerische Methoden zur Bayes-Inferenz.- 8 Prognose.- A Ergänzungen aus der Stochastik.- B Ergänzungen aus der linearen Algebra und Analysis.- C Ergänzungen aus der Numerik.- Literaturverzeichnis.- Index.
£31.34
Bohn,Scheltema & Holkema,The Netherlands Handboek Gezondheidszorgonderzoek
£54.14
Springer The Islets of Langerhans
Book SynopsisWhen new fellows join my lab, I give them some reading materials so that they can orient themselves in their assignment in a new eld. When fellows leave my lab, some after writing their dissertations, I prefer to give them a book as a symbolic present. I was longing for a book that contained something on more or less eve- thing about the islets. At the same time, I wished it contained information as recent as possible. There are a few such books in the market but they are pretty outdated. I started picking islets myself from October 1990, when I joined the Rolf Luft Center, Karolinska Institutet. Over the years my fascination for islet research remained high. Since last year, I felt a stronger urge to do more for these mysterious and hidden mini-organs that are directly or indirectly involved in the pathogenesis of all forms of diabetes that affects ?250 million people in the world. After I launched the Islet (landesbioscience. com/journals/islets) and founded the Islet Society (isletso- ety. org), there was a momentum that could be utilized to create something equally meaningful i. e. this book. The idea cracked in September 2008. Starting September 19, 2008, I contacted an estimated 90% of the authors who published anything on the islets during 2007–2008 and who could be traced from the internet.Trade Review"It looks very comprehensive and covers all current areas of interest and includes chapters written by world renowned contributors - very nice!"Matthias von Herrath, MDProfessor and Director, Center for Type 1 Diabetes ResearchLa Jolla Institute for Allergy and Immunology, La Jolla CA, USA "This book will be welcomed by islet researchers and clinicians interested in the latest developments and theories from which new therapeutics for diabetes can emerge". Martha Pavlakis, MDAssociate Professor of Medicine, Harvard Medical SchoolMedical Director, Kidney and Pancreas TransplantationBeth Israel Deaconess Medical CenterBoston, MA, USA "The field of islet biology is assuming increasing importance with the recognition that beta-cell dysfunction is a critical feature of type II diabetes. Improving b-cell function and/or b-cell mass may be the best approach to treating diabetes. Thus, the publication of a book covering so many aspects of this field is timely". Fred Levine, M.D., Ph.D.Professor, Burnham Institute for Medical ResearchDirector, Sanford Children's Health Research CenterLa Jolla, CA, USA "The growing prevalence of both type 1 and type 2 diabetes make islet cell biology a critical concern for a wide range of scientists and health professionals. From anatomy and developmental biology, through islet physiology and biochemistry, to issues of immunology and transplantation, this book is a terrific resource".Jonathan M.W.Slack, Ph.D., F.Med.Sci. Director, Stem Cell Institute, University of Minnesota, Medical SchoolMinneapolis, MN, USA "This book allows you to enjoy an adventurous and instructive guided tour in the archipelago of the islets of Langerhans. A team of expert and enthusiastic explorers will not only conduct the voyager through almost all niches of this complex and fascinating environment, but also provide him with clues and keys for future exploration of still hidden sites".Prof. Pellegrino MasielloDept. of Experimental Pathology,University of Pisa,Pisa, Italy "The pancreatic islet is a complex mini-organ whose dysfunction is critical in all forms of diabetes. This book provides a comprehensive review of the molecular and cellular processes in islet development, gene expression, and physiology and reviews how a better understanding of the pancreatic islet will advance efforts to develop new therapeutic approaches for diabetes. This book should be quite useful for anyone interested in the pancreatic islet or diabetes".Alvin C. Powers, M.D.Joe C. Davis Chair in Biomedical Science Professor of Medicine, Molecular Physiology and BiophysicsDirector, Vanderbilt Diabetes CenterVanderbilt UniversityNashville, TN USA "A very timely book on the Islet of Langerhans that coincides with the realization that pancreatic ß-cell failure is key to all forms of diabetes mellitus and research in the field is exploding. It contains very thoughtful chapters, each by renown experts in their field, and tackles the complexity of this micro-organ in health and disease very comprehensively and thoughtfully. It will likely become a Reference for years to come for basic researchers, clinicians and students interested is diabetes research"Marc Prentki, PhDProfessor of Nutrition and BiochemistryCanada Research Chair in Diabetes and MetabolismMDRC DirectorMontreal, QCCanada Table of ContentsCHAPTER 1 : Microscopic anatomy of the human islet of Langerhans - Peter In't Veld and Miriam Marichal CHAPTER 2 : The comparative anatomy of islets - Scott Heller CHAPTER 3: Approaches for imaging of islets: recent advances and future prospects - Ulf Ahlgren and Martin Gotthardt CHAPTER 4: Islet-cell Development - Anabel Rojas, Adrian Khoo, Juan R. Tejedo, Francisco J. Bedoya, Bernat Soria and Franz Martín CHAPTER 5: High fat programming of b-cell failure - Marlon. E. Cerf CHAPTER 6: Nutrient regulation of insulin secretion and b-cell functional integrity - Philip Newsholme, Celine Gaudel, and Neville H McClenaghan CHAPTER 7: Electrophysiology of islet cells - Gisela Drews, Peter Krippeit-Drews and Martina Düfer CHAPTER 8: ATP sensitive potassium channels in health and disease - Rebecca Clark and Peter Proks CHAPTER 9: Role of mitochondria in b-cell function and dysfunction - Pierre Maechler, Ning Li, Marina Casimir, Laurène Vetterli, Francesca Frigerio, Thierry Brun CHAPTER 10: Basement membrane in pancreatic islet function - Martin Kragl and Eckhard Lammert CHAPTER 11: Calcium signaling in the islets - Md. Shahidul Islam CHAPTER 12: Electrical bursting, calcium oscillations, and synchronization of pancreatic islets - Richard Bertram, Arthur Sherman, and Leslie S. Satin CHAPTER 13: Cyclic AMP signaling in pancreatic islets - Brian Furman, Wee Kiat Ong, and Nigel Pyne CHAPTER 14: Exocytosis in islet b-cells - Haruo Kasai, Hiroyasu Hatakeyama, Mitsuyo Ohno and Noriko Takahashi CHAPTER 15: The novel roles of glucagon-like peptide-1, angiotensin II, and vitamin D in islet function - Po Sing Leung CHAPTER 16: Proteomics and islets research - Meftun Ahmed CHAPTER 17: Wnt signaling in pancreatic islets - Zhengyu Liu and Joel F. Habener CHAPTER 18: Molecular pathways underlying the pathogenesis of pancreatic a-cell dysfunction - Dan Kawamori,Hannah J. Welters, and Rohit N. Kulkarni CHAPTER 19: Mechanisms of pancreatic b-cell apoptosis in diabetes and its therapies - James D. Johnson, Dan S. Luciani CHAPTER 20: b-cell function in obese-hyperglycaemic mice [ob/ob mice] - Per Lindström CHAPTER 21: Islet structure and function in the GK rat - B. Portha, G. Lacraz, A. Chavey, F. Figeac, M. Fradet, C. Tourrel-Cuzin, F. Homo-Delarche, M-H. Giroix, D. Bailbé, MN. Gangnerau, J. Movassat CHAPTER 22: The b-cell in human type 2 diabetes - Piero Marchetti, Roberto Lupi, Silvia Del Guerra, Marco Bugliani, Lorella Marselli and Ugo Boggi CHAPTER 23: Clinical approaches to preserve b-cell function in diabetes - Bernardo L. Wajchenberg CHAPTER 24: Immunology of b-cell destruction - Daria La Torre, and Åke Lenmark CHAPTER 25: Toll-like receptors and type 1 diabetes - Danny Zipris CHAPTER 26: Prevention of b-cell destruction in autoimmune diabetes: current approaches and future prospects - Saikiran K Sedimbi and Carani B Sanjeevi CHAPTER 27: In vivo regeneration of insulin-producing b-cell - Hee-Sook Jun CHAPTER 28: Customized cell-based treatment options to combat autoimmunity and restore b-cell function in Type I diabetes mellitus: current protocols and future perspectives - Fred Fändrich and Hendrik Ungefroren CHAPTER 29: The progammable cell of monocytic origin (PCMO): A potential adult stem/progenitor cell source for the generation of islet cells - Hendrik Ungefroren and Fred Fändrich CHAPTER 30: Islet isolation for clinical transplantation - Tatsuya Kin CHAPTER 31: Human islet autotransplantation: the trail thus far and the highway ahead - Martin Hermann, Raimund Margreiter and Paul Hengster CHAPTER 32: Modulation of early inflammatory reactions to promote engraftment and function of transplanted pancreatic islets in autoimmune diabetes - Lorenzo Piemonti, Luca G. Guidotti,
£237.49
World Health Organization Research priorities for zoonoses and marginalized
Book Synopsis
£41.13
World Health Organization World Report on Disability: 2011
Book Synopsis
£45.23
World Health Organization Summary report on the evaluation of short-term tests for carcinogens (collaborative study on In Vivo tests
£13.25
International Agency for Research on Cancer Statistical methods in cancer research Vol 1 The analysis of casecontrol studies Volume 1 The Analysis of CaseControl Studies v1 IARC scientific publications
£13.00
International Agency for Research on Cancer International Agency for Research on Cancer:
Book Synopsis
£30.23
International Agency for Research on Cancer A review of human carcinogens: D: Radiation
Book Synopsis
£57.39
International Agency for Research on Cancer Code of Good Scientific Practice: v. 4: IARC
Book Synopsis
£12.62
International Agency for Research on Cancer Sunscreens: IARC Handbook on Cancer Prevention:
Book Synopsis
£46.43
World Health Organization Verwirklichung Unserer Vision: Bericht Der
Book Synopsis
£28.50
World Health Organization Research Guidelines for Evaluating the Safety and
Book Synopsis
£10.69
WHO Regional Office for the Western Pacific Giving Adolescents a Voice: Conducting a Rapid
Book Synopsis
£10.53
Jaypee Brothers Medical Publishers Thesis Writing: The T, H, E, S, I, S Approach
Book SynopsisTable of Contents1 Role and Importance of Thesis in Postgraduate Training 2 Research Basic Concepts 3 Research Designs 4 Starting Research 5 Aim and Objectives 6 Review of Literature 7 Writing Synopsis 8 Material and Methods 9 Sample Size 10 Results and Inference 11 Managing Timeline: Forward Looking and Backward Looking Planning Tools 12 Ethical Issues in Thesis Research 13 Basic Statistics and Tests of Significance 14 Introduction to SPSS 15 Compilation of Thesis Work 16 Handling Revisions 17 Manuscript Based Thesis 18 Disseminating Thesis Research - Preparing a Quality Poster 19 Disseminating Thesis Research - Publication of Paper 20 Translational Education Research
£19.95
Jaypee Brothers Medical Publishers Research Methodology for Health Professionals:
Book SynopsisTable of Contents1. Introduction to Health Research What is Research? Why do Research? How to do Research? 2. Identification and Prioritization of Research Problems/Areas 3. Literature Search How to Find Out Available Information on the Research Problem/Area under Study? 4. Formulation of Objectives, Research Question, and Hypothesis 5. Planning the Measurements 6. Study Design Options in Medical and Health Research 7. Systematic Reviews and Meta-analysis 8. Research on Diagnostic Tests 9. Qualitative Research: Concepts and Methods 10. Variables 11. Determination of Sample Size and Power 12. Sampling Methods 13. Analysis of Quantitative Data 14. Analysis of Qualitative Data 15. Data Collection Methods and Techniques 16. Designing Research Instruments, Interview Guides, Skills and Validity of Questionnaire 17. Data Management, Processing, and Analysis 18. Quality Hospital Performance Indicators 19. Writing a Research Proposal 20. Scientific Research Funding 21. Steps in Thesis Writing The Art and Science of Writing Postgraduate Thesis/Dissertation 22. Writing and Publishing a Scientific Article 23. Plagiarism and its Prevention 24. Critical Review and Evaluation of Scientific Research Publications 25. Ethical Issues in Health Research Bibliography Index
£17.10
Jaypee Brothers Medical Publishers Interesting Cases in Echocardiography
Book SynopsisThis comprehensive text is a compilation of more than 250 clinical cases and 800 video clips from echocardiographers and cardiologists all over the world. Divided into eleven sections, cases cover all functions of the heart and associated disorders and infections. Most cases are presented in a uniform format, detailing patient history, clinical findings, echocardiographic images and video clips, one or more multiple choice questions with answers, followed by general discussion on the topic. The majority of cases have an emphasis in echocardiography, with some drawing comparisons with other techniques, predominantly magnetic resonance imaging (MRI) and computed tomographic (CT) scans. Edited by internationally recognised expert Navin C Nanda from University of Alabama, this book features nearly 600 images and a DVD ROM providing echocardiographic video clips. Key Points Compilation of more than 250 echocardiographic cases and 800 video clips Each case presented in uniform format with multiple choice questions and answers Edited by internationally recognised expert form University of Alabama Includes nearly 600 images and a DVD ROM Table of Contents Section 1. Mitral Valve Section 2. Aortic Valve, Aorta Section 3. Tricuspid And Pumonary Valves, Pulmonary Hypertension Section 4. Prostheses, Rings, Clips Section 5. Infection Endocarditis Section 6. Coronary Artery Disease Section 7. Left Ventricle, Right Ventricle & Cardiomyopathy Section 8. Pericardial Disorders Section 9. Tumors And Masses Section 10.Congenital Heart Disease Section 11. Miscellaneous
£216.00
Jaypee Brothers Medical Publishers Clinical Cases in Glaucoma: An Evidence Based
Book SynopsisGlaucoma is a condition of the eye in which the optic nerve is damaged due to increased fluid pressure in the eye. Left untreated, the condition may lead to permanent blindness. Presented as a collection of clinical case studies, this book is a complete guide to the treatment of glaucoma for both ophthalmologists and trainees. Beginning with an introduction to ocular hypertension, investigation techniques and the diagnosis of glaucoma, the following chapters describe different treatment methods. Potential surgical complications are discussed in detail to help clinicians determine the most appropriate management options. The final section covers clinical trials in glaucoma. Clinical photographs, flow charts and algorithms for patient management enhance learning. Key Points Comprehensive guide to diagnosis and treatment of glaucoma Presented as collection of clinical case studies In depth discussion on surgical complications Includes photographs, flow charts and algorithms to assist learning Table of Contents Ocular Hypertension Glaucoma Suspect Primary Open Angle Glaucoma Medical Therapy: Monotherapy, Fixed Combinations, Side Effects and Quality of Life Implications Laser Trabeculoplasty Angle Closure Glaucoma Trabeculectomy versus Tube Choice of Surgery: Nonpenetrating Deep Sclerectomy Transscleral Cyclophotocoagulation Endocyclophotocoagulation Complications after Trabeculectomy Tube Complications Complications of Nonpenetrating Deep Sclerectomy Complications of Newer Surgeries Glaucoma in Children Postrefractive Surgery Glaucoma Glaucoma after Vitreoretinal Surgery Neovascular Glaucoma Cataract and Glaucoma Compliance Informed Consents How to Overcome Imaging Artifacts and Prevent Misinterpretation of Imaging Results Sources of Errors While Interpreting Perimetry Sources of Errors While Performing and Interpreting Tonometry Clinical Trials in Glaucoma Basics of a Trial Design for Glaucoma
£63.65
Springer Advanced CMOS Biochips: Design and Fabrication
Book SynopsisBiochips incorporate a verity of means including electronic, photonic and microfluidic devices; biological materials (living cells, tissue, enzymes, nucleic acid and etc.) and chemical analysis to produce the detectable signals for identification of biological phenomena. Among several competing biochip technologies, Complementary Metal Oxide Semiconductor (CMOS) process offers the advantages of low cost, integrated, high precision and portable techniques suitable for point-of-care diagnostics. Advanced CMOS Biochip takes multi-path approach: microelectronic design and implementation of bio-interfaces offering a vital contemporary view of a wide range of integrated circuits and system for electrical, magnetic, optical and mechanical sensing and actuating blocks and much more; classical knowledge of biology, biochemistry as well as microfluidics. The coverage is both practical and in depth integrating experimental, theoretical and simulation examples. By using Advanced CMOS Biochip, readers will have the fundamentals and design techniques to grasp the situation which arise typically in CMOS biochip devices.Table of ContentsPromises of CMOS technology for biological applications.- Fundamental of Chemo-and bio-interfaces.- Electro-Microfluidics.- Integrated front-end devices.- Biochip circuit designs.- Micro-and nanofabrication post-processing methods.- Current and Emerging CMOS Technologies.
£81.00
Springer Clinical Laboratory Science in the Changing Scene of Health Care: Proceedings of the sixth ECCLS Seminar held at Cologne, West Germany, 8th–10th May, 1985
Book SynopsisList of Contributors ix PART 1 CURRENT CONCEPTS OF HEALTH AND HEALTH CARE 1 A European overview of the health care scene KS Johansen 3 Is there a European concept of health and health care? 2 JGW Wittkiimper 7 3 The effects of health and safety legislation on the practice of clinical laboratory science A Berlin, AE Bennett and WJ Hunter 19 4 Current economic, technical and political pressures at the laboratory level: some benefits towards health care delivery JG Lines and N Sanders 33 PART 2 THE CLINICAL LABORATORY IN THE CHANGING SCENE OF HEALTH CARE 5 The clinical laboratory in the changing scene of health care as seen by a professional society member M Roth 41 6 The clinical laboratory in the changing scene of health care as seen by an industry member JE Barclay 45 7 The clinical laboratory in the changing scene of health care as seen by a health agency member R Netter 55 8 The clinical laboratory in the changing scene of health care as seen in the USA R Nadeau 59 v CONTENTS PART 3 WOULD THE VALUE OF CLINICAL LABORATORY SCIENCE BE INCREASED BY FURTHER WRITTEN AND MATERIAL STANDARDS? 9 Would the value of clinical laboratory science be increased by further written and material standards in histology? J Rygaard 67 10 Would the value of clinical laboratory science be increased by further written and material standards in cytopathology? OAN Husain 73 11 Would the value of clinical laboratory science beTable of Contents1 Current Concepts of Health and Health Care.- 1 A European overview of the health care scene.- 2 Is there a European concept of health and health care?.- 3 The effects of health and safety legislation on the practice of clinical laboratory science.- 4 Current economic, technical and political pressures at the laboratory level: some benefits towards health care delivery.- 2 The Clinical Laboratory in the Changing Scene of Health Care.- 5 The clinical laboratory in the changing scene of health care as seen by a professional society member.- 6 The clinical laboratory in the changing scene of health care as seen by an industry member.- 7 The clinical laboratory in the changing scene of health care as seen by a health agency member.- 8 The clinical laboratory in the changing scene of health care as seen in the USA.- 3 Would The Value Of Clinical Laboratory Science be Increased by Further Written and Material Standards?.- 9 Would the value of clinical laboratory science be increased by further written and material standards in histology?.- 10 Would the value of clinical laboratory science be increased by further written and material standards in cytopathology?.- 11 Would the value of clinical laboratory science be increased by further written and material standards in microbiology?.- 12 Would the value of clinical laboratory science be increased by further written and material standards in immunology?.- 13 Would the value of clinical laboratory science be increased by further written and material standards in haematology?.- 14 Would the value of clinical laboratory science be increased by further written and material standards in clinical chemistry?.- 15 Would the value of clinical laboratory science be increased by further written and material standards in toxicology?.- 4 Future Eccls Involvement.- 16 Future ECCLS involvement as seen by industry.- 17 Future ECCLS involvement as seen by health agencies.- 18 Future ECCLS involvement as seen by professional societies.
£40.49
Springer Biomarkers of Radiation in the Environment:
Book SynopsisThis proceedings volume results from the NATO Advanced Research Workshop on 'Biomarkers of Radiation in the Environment: Robust Tools for Risk Assessment (BRITE)’. The BRITE workshop discussed insights from cancer research, epigenetics, non-human and human risk assessment, since many of the state-of-the-art biomarkers being developed for humans deserve consideration for environmental applications and vice versa. Sessions were very wide-ranging covering methods, mechanisms, cross disciplinary application and regulation.The chapters in this book have been grouped into five major themes that were covered by the BRITE workshop:· Techniques for biomarker development· Low-dose effect mechanisms· Biomarkers for risk evaluation· Biomarkers in wildlife· Biomarker use and responses Each chapter has been written independently and reflects the views of the chapter author(s). Therefore, the readers can form their own balanced view of the different perspectives on biomarkers of radiation in the environment. Given the breadth of topics covered and the state-of-the-art perspectives shared by leading experts in their respective fields, this book should form a valuable resource for anyone with an interest in how biomarkers can be used to improve our understanding of radiation in the environment and its potential impacts.Table of ContentsTECHNIQUES FOR BIOMARKER DEVELOPMENT.- Chapter 1. Reducing Uncertainties In Live Monitoring Of Radiation In Wildlife; T. Cresswell.- Chapter 2. Synchrotron Light Facilities And Applications In Life Sciences; V.M. Tsakanov.- Chapter 3. Elemental Imaging In Biology Using Synchrotron X-Ray Fluorescence Microscopy; K. Brown.-LOW-DOSE EFFECT MECHANISMS.- Chapter 4. Modelling Direct And Indirect Effects Of Radiation: Experimental, Clinical And Environmental Implications; S.C. Brueningk, G.P. Powathil.- Chapter 5. Immune Networks In The Context Of Low Dose Ionizing Radiation; D. Schaue et al.- Chapter 6. Learning From Nato Biomarker Research For Humans; A. Giovannetti et al.- BIOMARKERS FOR RISK EVALUATION.- Chapter 7. Exosomes As Radiation Biomarkers; K.K. Jella.- Chapter 8. Monitoring Very Low Dose Radiation Damage In Dna Using “Field-Friendly” Biomarkers; K. Rothkamm, S. Burdak-Rothkamm.- Chapter 9. The Development Of Bio-Assays Based On Non-Targeted Effects Of Radiation; A Potential Worm-Hole Into Ecosystem Level Biomarkers; C. Mothersill. BIOMARKERS IN WILDLIFE.- Chapter 10. Birds As Bioindicators Of Radioactive Contamination And Its Effects; A. Bonisoli-Alquati.- Chapter 11. Amphibians In Field Radioecology: A Review And Perspective; G. Orizaola.- Chapter 12. Measuring Adaptive Responses Following Chronic And Low Dose Exposure In Amphibians; M. Audette-Stuart et al.- Chapter 13. Are There Ecosystem-Relevant Endpoints For Measuring Radiation Impacts?; C. Bradshaw.-Chapter 14. Biomarkers And Ecological Indicators For Environmental Radioactivity In Invertebrates; K. Raines et al.- BIOMARKER USE AND RESPONSES.- Chapter 15. Biomarkers Of Radiation And Risk Assessment By Ionizing Radiation, Countermeasures For Radiation Protection Of Environment, Workers And Public; L. Qafmolla.- Chapter 16. Application Of The International System Of Radiation Protection In Fit-For-Purpose Assessment Of Impacts; T.L. Yankovich.- Chapter 17. Practicalities Of Mainstreaming Biomarker Use – A Canadian Perspective; S. Mihok, M. McKee.- Index.
£143.99
World Scientific Publishing Co Pte Ltd Optimal Control Of Drug Administration In Cancer
Book SynopsisThis monograph is a study of optimal control applied to cancer chemotherapy, the treatment of cancer using drugs that kill cancer cells. The aim is to determine whether current methods for the administration of chemotherapy are optimal, and if alternative regimens should be considered.The research utilizes the mathematical theory of optimal control, an active research area for many mathematicians, scientists, and engineers. It is of multidisciplinary nature, having been applied to areas ranging from engineering to biomedicine. The aim in optimal control is to achieve a given objective at minimum cost. A set of differential equations is used to describe the evolution in time of the process being modelled, and constraints limit the policies that can be used to attain the objective.In this monograph, mathematical models are used to construct optimal drug schedules. These are treatment guidelines specifying which drug to deliver, when, and at what dose. Many current drug schedules have been derived empirically, based upon “rules of thumb”.The monograph has been structured so that most of the high-level mathematics is introduced in a special appendix. In this way, a scientist can skip the more subtle aspects of the theory and still understand the biomedical applications that follow. However, the text is self-contained so that a deeper understanding of the mathematics of optimal control can be gained from the mathematical appendix.The mathematical models in this book and the associated computer simulations show that low intensity chemotherapy is a better choice of treatment than high intensity chemotherapy, under certain conditions.Table of ContentsBasic concepts; optimal control - theory and applications; multiple characteristic time (MCT) constraints; minimize the final tumour size; parameter uncertainty; forced decrease of tumour size; drug resistance I; drug resistance II; summary and conclusions; list of notation and symbols; appendix: elements of mathematical analysis.
£77.90
World Scientific Publishing Co Pte Ltd Statistical Methods for Biomedical Research
Book SynopsisThis book consists of four parts with 32 chapters adapted for four short courses, from the basic to the advanced levels of medical statistics (biostatistics), ideal for biomedical students . Part 1 is a compulsory course of Basic Statistics with descriptive statistics, parameter estimation and hypothesis test, simple correlation and regression. Part 2 is a selective course on Study Design and Implementation with sampling survey, interventional study, observational study, diagnosis study, data sorting and article writing. Part 3 is a specially curated course of Multivariate Analyses with complex analyses of variance, variety of regressions and classical multivariate analyses. Part 4 is a seminar course on Introduction to Advanced Statistical Methods with meta-analysis, time series, item response theory, structure equation model, multi-level model, bio-informatics, genetic statistics and data mining. The main body of each chapter is followed by five practical sections: Report Writing, Case Discrimination, Computer Experiments, Frequently Asked Questions and Summary, and Practice & Think. Moreover, there are 2 attached Appendices, Appendix A includes Introductions to SPSS, Excel and R respectively, and Appendix B includes all the programs, data and printouts for Computer Experiments in addition to the Tests for Review and the reference answers for Case Discrimination as well as Practice & Think.. This book can be used as a textbook for biomedical students at both under- and postgraduate levels. It can also serve as an importantguide for researchers, professionals and officers in the biomedical field.Table of ContentsIntroduction; Basic Concepts and Methods: Statistical Description; Probability Distribution; Parameter Estimation; Hypothesis Testing; Comparison of Means Between 2 Groups; Comparison of Means Among Multiple Groups; Comparison of Distributions of Categorical Variables; Analysis for Association; Simple Linear Regression; Design and Implementation of Bio-Medical Research: Sampling Survey; Interventional Study; Clinical Trial; Observational Comparative Effectiveness Research; Diagnostic Test; Sample Size Estimation; Missing Data; Statistical Guidelines for Medical Papers; Frequently Used Powerful Statistical Methods: Analysis of Variance for Complicated Designs; Multiple Linear Regression; Logistic Regression; Survival Analysis; Discriminant Analysis and Classification Tree; Cluster Analysis; Principal Component Analysis and Factor Analysis; Selected Topics of Advanced Statistics: Meta Analysis; Time Series; Structural Equation Model; Multi-Level Model; Item Response Theory; Statistics for Genetics; Statistics for Bio-Informatics; Data Mining; Appendices: Introduction for Statistical Software; Supplement for the Text; Statistical Tables; Index;
£198.00
Springer Verlag, Singapore Genome Data Analysis
Book SynopsisThis textbook describes recent advances in genomics and bioinformatics and provides numerous examples of genome data analysis that illustrate its relevance to real world problems and will improve the reader’s bioinformatics skills. Basic data preprocessing with normalization and filtering, primary pattern analysis, and machine learning algorithms using R and Python are demonstrated for gene-expression microarrays, genotyping microarrays, next-generation sequencing data, epigenomic data, and biological network and semantic analyses. In addition, detailed attention is devoted to integrative genomic data analysis, including multivariate data projection, gene-metabolic pathway mapping, automated biomolecular annotation, text mining of factual and literature databases, and integrated management of biomolecular databases. The textbook is primarily intended for life scientists, medical scientists, statisticians, data processing researchers, engineers, and other beginners in bioinformatics who are experiencing difficulty in approaching the field. However, it will also serve as a simple guideline for experts unfamiliar with the new, developing subfield of genomic analysis within bioinformatics.Table of Contents
£71.24
Springer Verlag, Singapore Human Epigenomics
Book SynopsisThe term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of epigenomics, the relation of which to human health and disease is discussed in this textbook. This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin). Moreover, this book discusses the principles of gene regulation, chromatin stability, genomic imprinting and the reversibility of DNA methylation and histone modifications. This information should enable a better understanding of cell type identities and will provide new directions for studies of, for example, cellular reprograming, the response of chromatin to environmental signals and epigenetic therapies that can improve or restore human health. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule “a picture tells more than thousand words”. The content of the book is based on the lecture course “Molecular Medicine and Genetics” that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. Thematically, this book is located between our textbooks “Mechanisms of Gene Regulation” (ISBN 978-94-017-7741-4) and “Nutrigenomics” (ISBN 978-3-319-30415-1), studying of which may also be interesting to our readers. The book is sub-divided into three sections and 13 chapters. Following the Introduction (section A), section B will explain the molecular basis of epigenomics, while section C will provide examples for the impact of epigenomics in human health and disease. The lecture course is primarily designed for Master level students of biomedicine, but is also frequented by PhD students as well as by students of other bioscience disciplines. Besides its value as a textbook, Human Epigenomics will be a useful reference for individuals working in biomedicine.Table of ContentsWhat is epigenomics?.- Methods and applications of epigenomics.- The structure of chromatin.- DNA methylation.- The histone code.- Chromatin modifiers.- Chromatin remodelers and organizers.- Embryogenesis and cellular differentiation.- Population epigenomics and aging.- Cancer epigenomics.- Neuroepigenetics.- Epigenomics of immune function.- Nutritional epigenomics.
£49.49
Springer Verlag, Singapore Molecular Hydrogen for Medicine: The Art of
Book SynopsisThis book provides a comprehensive account of the current status of molecular hydrogen medicine, a young field that emerged with the discovery that inhalation of hydrogen gas leads to the elimination of harmful reactive oxygen species in rats. Various physiologic effects have since been demonstrated, and possible medical applications identified. Numerous clinical projects have now been undertaken, yielding startling results. Despite this, molecular hydrogen medicine remains underappreciated among the medical community at large. The author aims to rectify this situation by fairly but critically evaluating the potential clinical benefits based on the latest scientific research. In addition, the observed physiological effects of hydrogen gas are considered within the broad context of the evolution of life on earth, offering new perspectives and helping to place molecular hydrogen medicine legitimately within the framework of life sciences. Written in an accessible manner, the book will be of value to students, researchers, clinicians, and the general public. Table of ContentsPart I What is Molecular Hydrogen Medicine?.- Chapter 1 The power of hydrogen molecules uncovered.- Chapter 2 Development of Molecular Hydrogen Medicine.- Chapter 3 From the front-line of research – Interviews.- Chapter 4 Physiological effects of the hydrogen molecule.- Chapter 5 Some fundamental properties of hydrogen and water.- Chapter 6 Functions of heavy water in living organisms.- Chapter 7 The future of Molecular Hydrogen Medicine.- Part II Tracing the History of Life and Hydrogen.- Chapter 8 The genesis of life in the world of hydrogen, Eons ago- Chapter 9 Drastic changes of living organisms in the oxygen age.- Chapter 10 Since the appearance of humans.
£21.84
Springer Verlag, Singapore Skin Cancer: Pathogenesis and Diagnosis
Book SynopsisThis book highlights the molecular and cellular mechanisms involved in the initiation and progression of skin cancer. It also explains the role of the environment in skin cancer development and explores the potential of microbiome in the diagnosis, prevention and treatment of skin cancer. The book also presents potential biomarkers for early detection of skin cancer and discusses recent advances in skin cancer prevention and treatment using photodynamic therapy. Lastly, it summarizes the applications of biomedical engineering, non-coding and nanotechnology in the diagnosis and therapeutics in skin cancer. It is a valuable resource for investigators in the field of skin cancer, including pathologists, medical and surgical oncologists, and dermatologists.Table of ContentsChapter 1. Cancer of the Skin:Type and Etiology.- Chapter 2. Therapeutic intervention in skin cancer: Future prospects.- Chapter 3. Melanin Based Classification of Skin Types and Their Susceptibility to UV-induced Cancer.- Chapter 4. The Epidemiology of Skin Cancer Worldwide.- Chapter 5. UV-R induced Vitamin D synthesis and skin cancer.- Chapter 6. The role of microbiome in the induction, diagnosis and therapy of skin cancer.- Chapter 7. Skin Cancer: Molecular Biomarker for Diagnosis, Prognosis, Prevention and Targeted Therapy.- Chapter 8. Therapeutics intervention of skin cancer in the OMICS era.- Chapter 9. Artificial intelligence in Skin Cancer: Diagnosis and Therapy.- Chapter 10. Biomedical engineering in cancer diagnosis and therapy.- Chapter 11. Skin cancer treatment with Emphasis on Nanotechnology.- Chapter 12. Non-long coding RNA and role in skin cancer diagnosis and therapy.- Chapter 13. Potential of long non-coding RNAs in the diagnosis and therapy of melanoma skin cancer.-
£134.99
Springer Verlag, Singapore Integrated Omics Approaches to Infectious
Book SynopsisThis book examines applications of multi-omics approaches for understanding disease etiology, pathogenesis, host-pathogen interactions. It also analyzes the genetics, immunological and metabolic mechanisms underlying the infections. The book also explores genomics, transcriptomics, translational-omics, and metabolomics approaches to understand the pathogenesis and identify potential drug targets. It reviews the role of epigenetic reprogramming in shaping the host-pathogen interactions and presents bioinformatics application in the identification of drug targets. Further, it examines the potential applications of RNA sequencing and non-coding RNA profiling to identify the pathogenesis. Lastly, it offers the current challenges, technological advances, and prospects of using multi-omics technologies in infectious biology.Table of ContentsChapter 1_Genomic Classification of Human Pathogens. –Chapter 2_Metagenomics of Human Microbiome. –Chapter 3_Genomic Landscape of Novel Coronavirus (2019-Ncov) Towards Better Diagnosis and Efficient Antiviral Therapies. –Chapter 4_Deciphering the Role of Epigenetic Reprogramming In Host-Pathogen Interactions. –Chapter 5_Applications of Next Generation Sequencing In Infectious Pathogens. –Chapter 6_Bioinformatics Applications in Human Pathogens. –Chapter 7_ Non-Coding RNA Profiling: Potential Application in Infectious Diseases. –Chapter 8_ Microarrays: A Road Map to Uncover Host Pathogen Interactions. –Chapter 9_RNA Sequencing as Strategy to Understand Pathogenesis. –Chapter 10_ Non-Coding RNA as Drug Target against Infectious Diseases. –Chapter 11_ Emerging Transcriptional Approach for Identification of Drug Targets in Human Pathogens. –Chapter 12_ Proteogenomics Applications in Human Pathogens.–Chapter 13_Proteomic Strategies for Understanding Host Pathogen Interactions.–Chapter 14_Antimicrobial and Therapeutic Peptides. –Chapter 15_ Structural Proteomics Guided Design of Antimicrobial Drugs and Vaccines. –Chapter 16_Mechanism of Action of Antimicrobial Agents against Clinically Important Pathogens: A Proteomic Approach. –Chapter 17_Application of Lipidomics in Understanding Host Pathogen Interaction. –Chapter 18_Metabolomics: Advances and Applications In Human Pathogens. –Chapter 19_Host-Pathogen Interactions: Nature Inspired Sialic Acid Based Biointerface Materials. –Chapter 20_Nanoparticles as Therapeutic Nanocargos Affecting Epigenome of Microbial Biofilms. –Chapter 21_Challenges and Prospects in Omics Approach to Pathogens
£161.99
Springer Verlag, Singapore BioSensing, Theranostics, and Medical Devices:
Book SynopsisThis book provides up-to-date information on the prototypes used to develop medical devices and explains the principles of biosensing and theranostics. It also discusses the development of biosensor and application-orientated design of medical devices. In addition to summarizing the clinical validation of the developed techniques and devices and the regulatory steps involved in their commercialization, the book highlights the latest research and translational technologies toward the development of point-of-care devices in the health care. Lastly, it explores the current opportunities, challenges and provides troubleshooting on the use of biosensors in precision medicine. The book is helpful for researchers and medical professionals working in the field of clinical theranostics, and medical-device development wanting to gain a better understanding into the principles and processes involved in the development of biosensors.Table of ContentsChapter 1_Biosensing: Material, methods and principle of detection.- Chapter 2_Biosensing applications in the development of medical devices.- Chapter 3_Theranostics: basic principles.- Chapter 4_Material and technique advancements in the development of theranostic products.- Chapter 5_Medical device development strategies.- Chapter 6_Research aspects for the development of medical devices.- Chapter 7_Biosensor-based commercialized point-of-care devices.- Chapter 8_Medical devices in clinical set up.- Chapter 9_Clinical validation of medical devices.- Chapter 10_Regulatory steps involved in the validation of medical devices.- Chapter 11_Protocol for registration process of point-of-care device at FDA or equivalent agencies.- Chapter 12_Opportunities and challenges in medical device development.- Chapter 13_Prospective journey of the research idea from laboratory to the user in the clinic.
£161.99
Springer Verlag, Singapore Crime Scene Management within Forensic science
Book SynopsisThis book provides deep insight into the significance of various forensic techniques underlying the methodical approaches in criminal investigations. The book comprises numerous case studies, examples, and reference materials. It emphasizes on the better practices for criminal investigations including contemporary examinations. The book also describes various methods for investigation of crime scene and evidence collection including biological evidences to the resources of law enforcement agencies. This book encompasses the procedure for crime scene-documentation through photography, video, and diagrams and highlights the best practices of packaging the biological evidences at a crime scene. Further, it summarizes the role of forensic autopsy to the criminal investigation system. As such, the book is helpful for forensic scientists, medical practitioners, educators and law enforcement personnel.Table of Contents1 Initial response at crime scenes and prioritization of efforts.- 2 Crime scene processing: documentation and evaluation.- 3 Crime Scene Searching: An Exploration of Forensic Evidence.- 4 Collection, Preservation and Packaging: Forensic Evidence Management.- 5 Paint, Soil and Glass Evidences: A Silent Witnesses.- 6 Questioned Document Examination: A Prevalent Dispute.- 7 Medicolegal Examination: A Guide to the Criminal Investigation System.- 8 Examination of Tampered Voice.
£116.99
Springer Verlag, Singapore How to Practice Academic Medicine and Publish
Book SynopsisThis is an open access book. The book provides an overview of the state of research in developing countries – Africa, Latin America, and Asia (especially India) and why research and publications are important in these regions. It addresses budding but struggling academics in low and middle-income countries. It is written mainly by senior colleagues who have experienced and recognized the challenges with design, documentation, and publication of health research in the developing world. The book includes short chapters providing insight into planning research at the undergraduate or postgraduate level, issues related to research ethics, and conduct of clinical trials. It also serves as a guide towards establishing a research question and research methodology. It covers important concepts such as writing a paper, the submission process, dealing with rejection and revisions, and covers additional topics such as planning lectures and presentations. The book will be useful for graduates, postgraduates, teachers as well as physicians and practitioners all over the developing world who are interested in academic medicine and wish to do medical research. Table of ContentsPart 1 Introduction 1 Academic Medicine and the Social Determinants of Health Part 2 Background 2 Why should we publish papers? 3 Overcoming the initial barriers to publication and the role of mentors? 4 When should we start doing research and publishing papers? 5 Does research improve patient care? 6 The status of biomedical research in some developing countries? Part 3 How to plan a study? 7 How to think of a research question? 8 What are the types of study design? 9 How to calculate an adequate sample size? 10 Understanding medical biostatistics 11 Applying biostatistics in medical research 12 Writing the research proposal: the art and the science 13 Ethics in research Part 4 How to write an original research paper? 14 Who should be an Author? 15 How to write an Abstract? 16 How to choose a Title? 17 How to write the Introduction to a scientific paper? 18 How to do a Review of the Literature? 19 How to write Material(Patients) and Methods? 20 How to write Results? 21 How to write the Discussion ? 22 How to Cite other papers and add References? 23 How to add Illustrations? 24 How to check for Plagiarism? 25 How to improve language and syntax in medical writing? Part 5 How to write other journal articles? 26 How to write an Editorial 27 How to write a Letter to the Editor? 28 How to write a Case Report 29 Systematic, Scoping and Narrative Reviews Part 6 After the paper is written 30 To which journal should you submit your article 31 Publication algorithm 32 How to do a Peer Review? 33 How to handle Rejection? 34 Bibliometrics Part 7 What else you should know about publication? 35 Is medical publishing lucrative? 36 How to start a New Medical Journal? Part 8 How to project your work further? 37 How to present a Poster in a conference 38 How to give an Oral presentation? Part 9 Education, planning and execution 39 Bedside teaching in Developing Countries 40 E-learning in the developing world 41 Develop learning objectives and evaluations- Multiple choice questions/ Objective Structured Practical Examination 42 How to prepare a lecture? 43 The Why and How of Problem based learning 44 How to conduct a Journal Club? Part 10 Other topics 45 Medical records 46 Clinical Audit 47 Clinical Drug Trials 48 Ethics in Genetic Testing
£33.24
Springer Verlag, Singapore Biomedical Translational Research: From Disease
Book SynopsisThe second volume of the Biomedical translational research discusses advancements in biomedical research for understanding the pathophysiology of various diseases towards improving diagnosis and treatment. It presents the integration of molecular-based technologies, clinical genomics, and medical informatics to improve diagnostic and treatment strategies. Further, the book reviews molecular genomics approaches for diagnosis and managing tuberculosis. It also covers the innovative strategies for cancer treatment through targeting metabolic pathways, tumor microenvironment, cancer stem cells, and immune cells. It also illuminates novel strategies for heart failure diagnosis and therapeutic approaches for the treatment of heart failure. It discusses improvements in translational research for discovery of new diagnostic tests, identifying novel biomarkers and drugable targets, and predicting optimal treatments based on understanding the underlying molecular basis of the disease. Lastly, it reviews the preclinical models of restenosis and their application and limitation in the evaluation of device-based interventional technologies for the treatment of coronary artery diseases.Table of Contents Application of clinical genomics in diagnosis and disease treatment Exosomes as novel biomarkers of disease Membrane Lipids: Implication for Diseases and Membrane Trafficking Human natural killer cells and their cytotoxic capacity Molecular genomic approaches for diagnosing and managing tuberculosis Exploring the origin of cancer with stem cell biology Therapeutic potential of skin stem cells in vitiligo Clinical applications of cancer stem cells Immuno therapeutic approaches for cancer treatment Future of uro-oncology Prostate Cancer: Circadian Gene Regulated Malignancy Role of adenosine pathway in cancer Immune modulation and VEGF Modulating tumour microenvironment in the treatment of cancer The endosymbiont role of mitochondria in cancer progression and therapy Interplay of cancer associated fibroblasts and tumour associated macrophages in metastasis Chimeric antigen receptor therapy : A cutting edge therapy for multiple myeloma The future therapies for heart failure Futuristic experimental studies on heart failure and ischemic heart diseases AGE-PAGE Stress in the pathophysiology of atherosclerosis and its treatment Genetics of Left Ventricular Dysfunction in Coronary Artery Disease Gene editing in liver disease Interrupting crystal to calculus conversion : The future of renal stone research Preclinical models of intimal hyperplastic and restenosis for the development of novel therapies Nanoparticles in counteracting multidrug resistant bacterial Rapid eye movement sleep and dream sleep
£161.99
Springer Verlag, Singapore Prebiotics, Probiotics and Nutraceuticals
Book SynopsisThe book titled ‘Prebiotics, Probiotics and Nutraceuticals’ is expected to direct many emerging research pathwaysneed at local and global levels for nutrition and food supplements for developing immunity for healthy life. This volume incorporates sixteen seminal papers on issue based research and their practical applications covering latest information and progress on different area of nutritional supplement research fight against disease. The book highlights the frontier issues and applications in nutritional biotechnology with wide coverage of the themes like Potentiality of Probiotics in Inactivation of Tetrodotoxin, Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics and Prospectives of Prebiotics, Probiotics and Synbiotics for Sustainable Development in Aquaculture.Plant based Bioactive compounds in Cancer Therapeutics, Recent Trends in Natural Medicines and Nutraceuticals Research, Probiotics as efficacious therapeutic option for treating gut-related diseases: molecular and immune-biological perspectives, The progressive development of probiotics, prebiotics, synbiotics research, and its multipurpose use in the ornamental fishery, The commercial perspective of probiotics, and bioremediating components in aquaculture pond management: A Case Study andPrebiotics as promising therapeutics for treating gut-related disorders : Biochemical and Molecular Perspectives. Prebiotics and Probiotics as Functional Foods: Prospect and Promises in Metabolic Diseases, Implications of probiotics and prebiotics on immune functions. Recent Trends in Natural Medicines and Nutraceuticals Research, Nutraceuticals are alternative to modern medicines, Socio-Economic Study of Prospective of probiotic, prebiotic and synbiotic for sustainable development of aquaculture in Indian Sunderban. This book will be very useful for the scholars, biotechnologists, agricultural scientists, nutritionist, medical doctors, researchers, teachers and students in the emerging field of biotechnology.Table of Contentsa. Advances in Microbial Fermentation and Fermented Food product for Health b. Application of Computational Intelligence Techniques for in Prebiotics, Probiotics, and Nutraceuticals. c. Advances in Genetic Engineering technologies leading to the development of Prebiotics, Probiotics, and Nutraceuticals. d.The Commercial Perspective of Prebiotics, Probiotics, and Nutraceuticals components. e. Innovative technologies linked with the Prebiotics, Probiotics and associated elements. f. Benefits of Probiotics components and effects in immunological purposes. g. Emerging prospects and challenges of Probiotics and Prebiotics to human health. h. Wild edible plants the rich source of Nutraceuticals i. Probiotics Microbes and Biomedical Applications j. Marine Probiotics and Prebiotics for therapeutic application k. Recent Trends in Natural Medicines and Nutraceuticals Research l. Prospective of Probiotic, Prebiotic and Synbiotic for sustainable development of aquaculture
£116.99
Springer Verlag, Singapore Sphingolipid Metabolism and Metabolic Disease
Book SynopsisThis book provides an up-to-date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases. Focusing on the sphingolipid de novo synthesis pathway, the effect of sphingomyelin, ceramide, and sphingosine-1-phosphate, and linkage between sphingolipids and other lipids, such as cholesterol, it covers serine palmitoyltransferase, ceramide synthases, ceramidases, sphingosine kinases, and sphingomyelin synthases, and more. While highlighting how rare diseases related to abnormal glycosphingolipid metabolism, this publication introduces sphingolipid metabolism-related diseases, such as lung diseases and cancers, as well as sphingolipid circadian regulation. The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases. It offers graduate students and researchers a coherent overview of sphingolipids, as well as the limitations of current research in the field, and promotes further studies on metabolic diseases, as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase.Table of ContentsChapter 1: Sphingolipids and Cholesterol.- Chapter 2: Sphingolipids in adipose: kin or foe?.- Chapter 3: De novo sphingolipid biosynthesis in atherosclerosis.- Chapter 4: Serine Palmitoyltransferase Subunit 3 and Metabolic Diseases.- Chapter 5: Molecular mechanisms of sphingolipid transport on plasma lipoproteins.- Chapter 6: Sphingosine 1-phosphate metabolism and signaling.- Chapter 7: Sphingomyelin synthase family and phospholipase Cs.- Chapter 8: Sphingolipid metabolism and signaling in endothelial cell functions.- Chapter 9: Cholesterol metabolism in chronic kidney disease: physiology, pathologic mechanisms, and treatment.- Chapter 10: Sphingolipids and asthma.- Chaper 11: Manifold Roles of Ceramide Metabolism in Nonalcoholic Fatty Liver Disease and Liver Cancer.- Chapter 12: Drug development in the field of sphinogolipid metabolism.- Chapter 13: Rare diseases in glycosphingolipid metabolism.
£125.99
Springer Verlag, Singapore Microfluidics and Multi Organs on Chip
Book SynopsisThis book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.Table of ContentsChapter 1. A Historical and Technological Background to Organs-on-a-Chip.- Chapter 2. Applications of microfluidics.- Chapter 3. Microfluidics based Organ-on-a-chip for cell biology studies.- Chapter 4. Microfluidics in Chemical biology.- Chapter 5. Role of microfluidics in drug delivery.- Chapter 6. Microfluidics in drug discovery.- Chapter 7. Microfludic based sensors.- Chapter 8. Background and Organs-on-a-Chip.- Chapter 9. Culture and co-culture of cells for multi organ on chip.- Chapter 10.Cells and organs on a chip in biomedical sciences.- Chapter 11. Futuristic aspects of organ on a chip.- Chapter 12. Development of Human on a chip.- Chapter 13. Multi-organ on a chip for personalized medicine.- Chapter 14. Development and application of Microfluids in organoid formation.- Chapter 15. Liver on a chip.- Chapter 16. Placenta on Chip: A Modern approach to probe feto-maternal interface.- Chapter 17. Microfluidic retina-on-chip.- Chapter 18. Heart on a chip.- Chapter 19. Kidney on a chip.- Chapter 20. Lungs on a chip.- Chapter 21. Brain on a chip.- Chapter 22. Skin on a chip.- Chapter 23. Organs-on-a-chip in preclinical studies.- Chapter 24. Application of organ on chip in blood brain barrier model.- Chapter 25. Multi organs on a chip in disease modeling.- Chapter 26. Prospects of Medical device on a chip.- Chapter 27. Lab on a chip for precision Medicine.- Chapter 28. Tumour-on-a-chip : Perfusion systems to model the extracellular breast tumour microenvironment:from tumour progression to metastasis formation.- Chapter 29. Building Human In Vitro 3D Models to Replace Animal Studies: During Drug Discovery Reearch: Scientific, Ethical and Regulatory Considerations.
£161.99
Springer Verlag, Singapore Drug Targets for Plasmodium Falciparum Historic
Book SynopsisThis book offers a comprehensive exploration of malaria, a life-threatening disease affecting millions globally, with a focus on the parasitic organisms of the genus Plasmodium that cause it.
£98.99
Springer Verlag, Singapore Cognizance of Schizophrenia:: A Profound Insight
Book SynopsisThis book provides the reader with a thorough understanding of schizophrenia as a complex brain disorder by explaining the various aspects investigated for its cognizance from epigenetics to chemistry and physics to computational approaches. The book covers the key notions of schizophrenia from a variety of facets such as neurogenetics, neurochemistry, neuropharmacology, neurobiology, psychotherapy, psychiatric treatment, cognitive studies, behavioral and societal studies, and computational neurosciences. Individual chapters are focused on crucial topics such as cognitive-behavioral therapy, brain functioning, computational neuroscience, neuro-imaging, and many more. This book explains each section and chapter with utmost clarity to maintain comprehensiveness for every kind of reader. This book covers various classical as well as recent topics from basic to advance level knowledge regarding schizophrenia. The book's contributions regarding its inclusivity of topics, comprehensiveness of language, diversity in knowledge, and focus on the subject will attract all kinds of readers. It can be considered a single comprehensive handy reference book for beginners, including medical students, neuroscientists, researchers, clinicians, and medical practitioners. Cognizance of Schizophrenia will be an invaluable asset for all who are involved in neuroscience research or clinical studies.Table of Contents Understanding schizophrenia: introductory aspect of the mental disorder from various perspectives Genetic mutations and Alternative splicing in schizophrenia Understanding the Chemical Interactions in the Brain of Schizophrenia Patients A diagnostic perspective of schizophrenia: from past to present Is it schizophrenia or not? - Different Biological characterization A neurobiological aspect of schizophrenia and the relationship between neurological disorders: depression, anxiety, epilepsy Clinical treatment available for schizophrenia Insights into the neuro-pharmacological treatment of schizophrenia: past, present, and future Managing Schizophrenia – A Challenge for Physicians Pharmacotherapy and Emerging Treatment Strategies for Schizophrenia Alternative Therapies used in Schizophrenia Different phases of schizophrenia patients: from the psychological perspective Stigmatizing Attitudes Towards Patients with Schizophrenia Among Medical Professionals and General Population Rehabilitation of Schizophrenia-Practical Interventions Consumption of Cannabis: A risk factor or a therapeutic agent for patients with Schizophrenia Medical Imaging and Schizophrenia: A Study on State-of-art Applications Schizophrenia and its Effect on Marital Satisfaction The mortality rate in schizophrenia
£116.99
Springer Verlag, Singapore Glycosignals in Cancer: Molecular Assembly and
Book SynopsisThis book, now in an extensively revised second edition, provides a comprehensive summary of the latest knowledge regarding glycosignals and a thorough analysis of their involvement in not only cancers but also other refractory conditions such as chronic inflammatory disorders. Many relevant topics are covered, including the search for novel tumor epitopes related to carbohydrates, the assembly of glycoconjugates, the modulation of signaling pathways by glycosylation, and interactions between complex carbohydrates and their recognition molecules. The role of various research approaches, for example advanced mass spectrometry, high-resolution imaging, and bioinformatics, is closely examined, and the results of novel therapeutic trials targeting glycosignals are discussed. The book will be essential reading for students and young researchers with an interest in glycoscience. In presenting new results and approaches and identifying areas for future research, it will also be of benefit for specialists in the field.Table of ContentsPart I. Search for novel tumor epitopes related to carbohydrates.- Chapter 1.1. The ganglioside structures: chemistry and biochemistry.- Chapter 1.2. Fucosylated proteins as cancer biomarkers.- Part II. Assembly of glycoconjugates.- Chapter 2.1. Siglec-7 and synthetic sialylpolymer.- Chapter 2.2. Role of Sialyl-Tn antigen in Cancer Metastasis.- Chapter 2.3. Insights into the Role of Chondroitin Sulfate in Cancer.- Part III. Signaling pathways modulated by glycosylation.- Chapter 3.1. Significance of FUT8in pancreatic cancer and others.- Chapter 3.2. Effects of Bullfrog sialic acid-binding lectin in cancer cells.- Part IV. Interaction between carbohydrate and carbohydrate-recognizing molecules.- Chapter 4.1. Opposite functions of mono- and disialylated glycosphingolipids on the membrane of cancer cells.- Chapter 4.2. Tumor progression through interaction of mucins with lectins and subsequent signal transduction.- Part V. Clinical trials targeting glycosignals.- Chapter 5.1. Immunotherapy of Neuroblastoma Targeting GD2 and Beyond.
£123.49
Springer Verlag, Singapore Microbial Genomic Islands in Adaptation and
Book SynopsisThis book elucidates the role of microbial genomic islands (GEIs) in genome stability, plasticity, evolutionary adaptation, and pathogenicity in the bacterial population. The initial chapters of the book present tools, including bioinformatics, artificial intelligence, machine learning, next-generation sequencing, and molecular biology techniques, for the analysis of the genomic islands. The book also discusses the importance of genomic islands in bacterial speciation, acquisition of genes related to resistome, nitrogen fixation, mobilomes, and nutritional fitness and adaptation. It provides recent advances in understanding microbial genomic islands' distribution, evolution, and mechanistic modes of behavior in pathogenic, non-pathogenic, and environmental species. This book is a valuable source for beginners in molecular microbiology, students, researchers, clinicians, stakeholders, and policymakers interested in understanding the role of GEIs in the adaptive evolution of microorganisms. Table of ContentsChapter 1. An introduction of microbial genomic islands for evolutionary adaptation and pathogenicity.- Chapter 2. Computation tools for prediction and analysis of genomic islands.- Chapter 3. An overview of genomic islands’ main features and computational prediction: the CMNR group of bacteria as a case study.- Chapter 4. Microbial genomic island discovery, visualization and analysis.- Chapter 5. Genomic islands in bacterial genome evolution and speciation.- Chapter 6. Genomic islands in the gut microbiome: current knowledge and the application in the probiotics field.- Chapter 7. Genomic islands in nutritional fitness and adaptation.- Chapter 8. Genomic islands involved in iron uptake.- Chapter 9. Genomic islands in uropathogeneic E. coli.- Chapter 10. Genomic islands in Helicobacter species.- Chapter 11. Genomic islands in Staphylococcus.- Chapter 12. Genomic islands in Pseudomonas species.- Chapter 13. Genomic islands in Klebsiella pneumonia.- Chapter 14. Molecular Insights into Genomic Islands and Evolution of Vibrio cholerae.- Chapter 15. Genomic islands in marine bacteria.- Chapter 16. Challenges in Eventing Horizontal Gene Transfer.- chapter 17. Artificial Intelligence and machine learning for prediction and analysis of genomic islands.
£151.99
World Scientific Publishing Co Pte Ltd Training Of Cancer Researchers, The
Book SynopsisAdvances in cancer research have grown exponentially in recent decades. What we now know about the disease owes a lot to breakthroughs in science and technology. Cancer researchers have had to solve increasingly difficult problems with methods that were unimaginable just a few years ago, and new generations of researchers have to be trained to face these challenges.One important aspect of their training is the framing of social, economic and cultural changes of the human population. Despite having state-of-the-art technology and specializations, researchers are still required to think faster than ever before, making new discoveries fit the practical situation of each type of cancer. This book discusses a number of topics that address these challenges and the origins of cancer research from a cultural and historical perspective.
£61.75
World Scientific Publishing Co Pte Ltd Memoirs Of A Cancer Researcher
Book SynopsisThis narrative of a cancer researcher spans a period in which biomedicine research has been so revolutionary. The educational background and socioeconomic circumstances of the author make the story unique, shedding light on many important intellectual achievements. The author also provides an insightful view on how decisions at the upper echelon of scientific institutions affect cancer researchers. The vivid account of scientific discovery and intellectual evolution provides a fine example for the next generation of cancer researchers.
£76.00
World Scientific Publishing Co Pte Ltd Tools Of Science, The: The Handbook For The
Book SynopsisThis book aims to provide useful tips for the understanding of scientific research processes and practical advice for people engaged in this field. It is a reflection of the author's more than 40 years of experience in medical and cancer research, and is written in a colloquial style to reach not only the young audience who are considering devoting their lives to biomedical research, but also to those who are already engaged in this field. The author emphasizes the unique traits and qualifications required for performing scientific research and also describes the different modalities which can be performed in our actual scientific environment. There are numerous practical advices in this book, such as guidelines on writing a grant proposal and the first peer-reviewed manuscript, the selection criteria of the training laboratory and mentors, as well as experimental record The author also provides his insight on the personal inner drive and motivation critical for conducting scientific research, as well as the importance of working on a problem without losing the human perspective of this specific and unique human endeavor.Table of ContentsProfile of a Scientific Researcher; Research Ideas; The Paper; The Grant Application; What is a Research Laboratory?; Interactive Groups in Scientific Research; Laboratory Protocol Books; The Ten Fatal Mistakes; What is Expected from the Apprentice of Science?; Reflections.
£43.70
World Scientific Publishing Co Pte Ltd Electrochemistry For Biomedical Researchers
Book SynopsisThis book is a brief introductory text of the fundamental electrochemistry that is essential for important biomedical areas including electrophysiology, biosensors and even gene technology. The book targets readers who generally lack a substantial background knowledge in physical chemistry or the basic concepts in electricity for understanding most of the electrochemical textbooks, monographs or research articles. The contents are expressed in a concise and concept-by-concept manner with basic material such as math or optional applications appended in the appendices. Hopefully, it will be a quick and efficient solution for those who are eager to understand, handle and even develop an electrochemical method or tool by themselves.Co-publish with National Taiwan University. Distributed worldwide by World Scientific Publishing Co. except Taiwan.Table of ContentsMembrane Potential; Conductivity; Redox Potential; Amperometric Measurement; Steady-State Voltammetry; Transient Voltammetry; Interface Impedance; Oscillation and QCM; Electrophoresis.
£53.20
World Scientific Publishing Co Pte Ltd Methods In Research And Development Of Biomedical
Book SynopsisThis book presents a road map for applying the stages in conceptualization, evaluation, and testing of biomedical devices in a systematic order of approach, leading to solutions for medical problems within a well-deserved safety limit. The issues discussed will pave the way for understanding the preliminary concepts used in modern biomedical device engineering, which include medical imaging, computational fluid dynamics, finite element analysis, particle image velocimetry, and rapid prototyping. This book would undoubtedly be of use to biomedical engineers, medical doctors, radiologists, and any other professionals related to the research and development of devices for health care.Table of ContentsIntroduction; Overview of Biomedical Technologies; Conceptualisation and Medical Image-Based Modelling; Medical Imaging and Visualisation; Treatment of Aneurysms; Endovascular Stent Grafts; Nasal Drug Delivery; Biomedical MEMS Micropump; Engineering and Production Management for Biomedical Devices.
£76.95
World Scientific Publishing Co Pte Ltd Selected Topics In Nanomedicine
Book SynopsisNanomedicine consists of the use of nanotechnology and nanobiotechnology in medicine. There have been extensive developments in the area of nanomedicine. The scope of this book is first to discuss the origin of nanomedicine. Following this, instead of a general overview of the whole area, 24 chapters on selected topics of important areas are described in detail. Authors are selected from around the world to give a representative and international view of the activities in the area of nanomedicine.Table of ContentsArtificial Cells: The Beginning of Nanomedicine (Thomas M S Chang); The Clinical Development of Hemopure(R): A Selective Commentary (A Gerson Greenburg); Glutaraldehyde Polymerized Porcine Haemoglobin (Chao Chen Zhu); Evidences Regarding Some Pharmacologic Characteristics of Haemoglobin based Oxtgen Carriers (Enrico Bucci); EAF PEG Hemoglobins: Novel Class of Non-Hypertensive Resuscitation Fluids: Simplicity and Advantages of Extension Arm Chemistry for Pegylation (Seetharama A Acharya, Amy G Tsai and Marcos Intaglietta); Biocompatibility of a Highly Concentrated Fluid of Hemoglobin-Vesicles as a Transfusion Alternative (Hiromi Sakai); Molecular Basis of Haptoglobin and Hemoglobin Complex Formation and Protection Against Oxidative Stress and Damage (Yiping Jia and Abdu I Alayash); Polynitroxylated Hemoglobin as a Multifunctional Therapeutic for Critical Care and Transfusion Medicine (Li Ma and Carleton Jen Chang Hsia); Surface Mediated Drug Delivery (Benjamin M Wohl, Betina Fejerskov, Siow-Feng Chong and Alexander N Zelikin); Use of Tunable Pores for Accurate Characterization of Micro- & Nano-Particle Systems in Nanomedicine (James Eldridge, Aaron H Colby, Geoff Willmott, Sam Yu and Mark W Grinstaff); Microfluidic Probes to Process Surfaces, Cells, and Tissues (Mohammad A Qasaimeh, Sebastien Ricoult and David Juncker); Subcompartmetalized Systems Toward Therapeutic Cell Mimics (Leticia Hosta-Rigau and Brigitte Stadler); Soft Magnetic Nanomaterials Towards Nanomedicine: Magnetism Principles, Preparation, Characterization and Potential Applications (G W Qin1, S Li1, Y P Ren1, F Darain and K Dimitrov); GoldMag Composite Particles and Their Applications in Nanomedicine (Mingli Peng, Xu Chao, Chao Chen and Yali Cui); Nanoparticles for Imaging and Therapy - Functionalization, Endocytosis and Characterization (Yu Zhang, Yi Li, Gurer Budak, Mihrimah Ozkan and Cengiz S Ozkan); Noscapines: Novel Carrier Systems to Target the Tumour Cells (Ramesh Chandra1, J Madan1, Prashant Singh, Pradeep Kumar, V Tomar1and Sujata and K Dass); High Throughput Methods for Miniaturization of Implantable Artificial Cells (Maryam Mobed-Miremadi); Core-Shell Nanoparticles Containing Hairy Polyethyleneimine Shells as Effective Nanocarriers for Gene Delivery (Yuen Shan Siu, Kin Man Ho and Pei Li); Polymeric and Metallic Nanoparticles for Imaging and Treating Inflammation in the Nervous System (S Boridy, and D Maysinger); Bio-Functional Polymer Vesicles for Applications in Nanomedicine (Hans-Peter M De Hoog, Bo Liedberg and Madhavan Nallani); Carbon Nanotubes in Cancer and Stem Cell Therapeutics (Wei Shao, Arghya Paul and Satya Prakash); Application of Polyethylenimine Based Nanoparticles for RNA Therapeutics (Surendra Nimesh and Ramesh Chandra); Chitosan Based Nanocarriers for Efficient and Targeted Sirna Delivery (Surendra Nimesh and Ramesh Chandra).
£171.00
World Scientific Publishing Co Pte Ltd Lost In Translation: Barriers To Incentives For
Book SynopsisThis book is all about the definition and finding ways to prioritize and accelerate translation research in biomedical sciences and rapidly turning new knowledge into first-in-human studies. It represents an effort to bring together scientists active in various areas of translational research to share science and, hopefully, generate new ideas and potential collaborations. The book provides a comprehensive overview of translational work that includes significant discoveries and pioneering contributions, e.g., in immunology, gene therapy, stem cells and population sciences. It may be used as an advanced textbook by graduate students and even ambitious undergraduates in biomedical sciences. It is also suitable for non-experts, i.e. medical doctors, who wish to have an overview of some of the fundamental models in translational research.Managing the translational enterprise remains a work in progress. The world is changing rapidly, and the scientific world needs to seek new ways to ensure that discoveries get translated for patients efficiently and as quickly as possible. In addition, everyone expects the investment in biomedical research should pay dividends through effective therapeutic solutions. This unique project provides a broad collaborative approach of the international scientific team to present its view and opinion how to cross barriers to incentives for translational research in medical sciences.Contributing to the book is an international team of prominent co-authors. The book consists of unique and widely treated topics, and includes new hypotheses, data and analyses.Table of ContentsIntegrating Emerging Science into Clinical Practice; Organization, Prioritization, Review and Funding for the Translational Research in the USA; Organization of the Translational Research elsewhere in the World; Translational Sciences in Cancer Research; Translational Science and Infectious Diseases; Translation Research and Neuroscience; Stem Cells and Translation Research; Translation Research in Nutrition and Endocrinology; The Role of Translational Research in Behavioral Sciences and Public Health; Translational Epidemiology, Biostatistics and Informatics; Translational Research Outcomes; Translational Research Resources.
£220.50
World Scientific Publishing Co Pte Ltd Debating Cancer: The Paradox In Cancer Research
Book SynopsisCancer research is at a crossroads. Traditionally, cancer has been thought of as a disease of gene mutation, where the stepwise accumulation of cancer gene mutations is the key, and the identification of common gene mutations has been considered to be essential for diagnosis and treatment. Despite extensive research efforts and accumulated knowledge on cancer genes and pathways, the clinical benefits of this traditional approach have been limited. Recently, cancer genome sequencing has revealed an extensive amount of genetic heterogeneity where the long-expected common mutation drivers have been difficult, if not impossible, to identify. These realities ultimately challenge the conceptual framework of current cancer biology.This book introduces a new concept of genome theory of cancer evolution, in an attempt to unify the field. Many important and representative, but often confusing, questions and paradoxes are critically analyzed. By comparing gene- and genome-based theories, the hidden flaws of many popular viewpoints are addressed. This discussion is intended to initiate a much-needed critical re-evaluation of current cancer research.Table of ContentsGene Mutation Theory vs. Genome Theory; Cancer Genome Landscape: The Untold Story of Cancer Genome Sequencing; Lottery Principle: The Gene, Genome, Environment, and the Perfect Storm; Examples of Popular but Flawed Concepts about Cancer; Why "Noise" is Important in Cancer Evolution; Why Basic Research Fails to Bridge the Gap with the Clinic World; Do Different Cancers Represent Different Species?; Challenging Current Molecular Methodologies for Cancer Research.
£124.20
World Scientific Publishing Co Pte Ltd Bioprinting: Principles And Applications
Book SynopsisAt labs around the world, researchers have been experimenting with bioprinting, first just to see whether it was possible to push cells through a printhead without killing them (in most cases it is), and then trying to make cartilage, bone, skin, blood vessels, small bits of liver and other tissues. There are other ways to try to “engineer” tissue — one involves creating a scaffold out of plastics or other materials and adding cells to it. In theory, at least, a bioprinter has advantages in manipulating control of the placement of cells and other components to mimic natural structures.But just as the claims made for 3-D printing technology sometimes exceed the reality, the field of bioprinting has seen its share of hype. The reality is that, although bioprinting researchers have made great strides, there are many formidable obstacles to overcome. Nobody who has any credibility claims they can print organs, or believes in their heart of hearts that that will happen in the next 20 years, but for operations like hip replacement, advance in Bio-printing has made customization of certain body parts possible.This book will start from the concept of Tissue Engineering, covering various approaches in Scaffolds for tissue engineering, Bioprinting techniques and Materials for bioprinting, Cell processing, 3D cell culture techniques, Computational design and simulation, multi-disciplinary approaches in bioprinting and finally cover the applications of bioprinting.
£57.00
