Description

Book Synopsis

Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more.

Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field.



Table of Contents

Part I: Overview

1. The History of Cellular Therapies

2. Basics of Immunity


Part II: CAR-T

3. Biology of CAR-T

4. Cell Types Used for CAR-T Generation

5. Combination Therapeutics with CAR-T Cell Therapy

6. Safety Switches Used for Cellular Therapies

7. Off the Shelf CAR-T

8. Manufacturing of CAR-T Cells: the Assembly Line

9. Navigating Regulations in Gene and Cell Immunotherapy

10. Bringing CAR-T to the Clinic

11. CAR-T Cell Complications

12. Mechanisms of Resistance and Relapse after CAR-T Cell Therapy

Part III: TIL

13. Tumor Infiltrating Lymphocytes (TIL): From Bench to Bedside

Part IV: TCR

14. T-cell Receptor (TCR) Engineered Cells and Their Transition to Clinic

Part V: Viral CTLs

15. Viral Cytotoxic T Lymphocytes (CTLs): from Bench to Bedside


Part VI: NK Cell

16. Biology of NK Cells and NK Cells in Clinic

Part VII: T/NK cell engagers

17. Biology and Clinical Evaluation of T/NK Cell Engagers

Part VIII: Logistics

18. Roadmap for Starting an Outpatient Cellular Therapy Program

Gene and Cellular Immunotherapy for Cancer

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    RRP £129.99 – you save £13.00 (10%)

    Order before 4pm tomorrow for delivery by Thu 2 Jul 2026.

    A Hardback by Armin Ghobadi, John F. DiPersio

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      Publisher: Springer Nature Switzerland AG
      Publication Date: 20/12/2021
      ISBN13: 9783030878481, 978-3030878481
      ISBN10: 3030878481
      Also in:
      Medical microbiology and virology Medical research Pharmacology

      Description

      Book Synopsis

      Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more.

      Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field.



      Table of Contents

      Part I: Overview

      1. The History of Cellular Therapies

      2. Basics of Immunity


      Part II: CAR-T

      3. Biology of CAR-T

      4. Cell Types Used for CAR-T Generation

      5. Combination Therapeutics with CAR-T Cell Therapy

      6. Safety Switches Used for Cellular Therapies

      7. Off the Shelf CAR-T

      8. Manufacturing of CAR-T Cells: the Assembly Line

      9. Navigating Regulations in Gene and Cell Immunotherapy

      10. Bringing CAR-T to the Clinic

      11. CAR-T Cell Complications

      12. Mechanisms of Resistance and Relapse after CAR-T Cell Therapy

      Part III: TIL

      13. Tumor Infiltrating Lymphocytes (TIL): From Bench to Bedside

      Part IV: TCR

      14. T-cell Receptor (TCR) Engineered Cells and Their Transition to Clinic

      Part V: Viral CTLs

      15. Viral Cytotoxic T Lymphocytes (CTLs): from Bench to Bedside


      Part VI: NK Cell

      16. Biology of NK Cells and NK Cells in Clinic

      Part VII: T/NK cell engagers

      17. Biology and Clinical Evaluation of T/NK Cell Engagers

      Part VIII: Logistics

      18. Roadmap for Starting an Outpatient Cellular Therapy Program

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