Description
Book SynopsisClinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more.
Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field.
Table of ContentsPart I: Overview
1. The History of Cellular Therapies
2. Basics of Immunity
Part II: CAR-T
3. Biology of CAR-T
4. Cell Types Used for CAR-T Generation
5. Combination Therapeutics with CAR-T Cell Therapy
6. Safety Switches Used for Cellular Therapies
7. Off the Shelf CAR-T
8. Manufacturing of CAR-T Cells: the Assembly Line
9. Navigating Regulations in Gene and Cell Immunotherapy
10. Bringing CAR-T to the Clinic
11. CAR-T Cell Complications
12. Mechanisms of Resistance and Relapse after CAR-T Cell Therapy
Part III: TIL
13. Tumor Infiltrating Lymphocytes (TIL): From Bench to Bedside
Part IV: TCR
14. T-cell Receptor (TCR) Engineered Cells and Their Transition to Clinic
Part V: Viral CTLs
15. Viral Cytotoxic T Lymphocytes (CTLs): from Bench to Bedside
Part VI: NK Cell
16. Biology of NK Cells and NK Cells in Clinic
Part VII: T/NK cell engagers
17. Biology and Clinical Evaluation of T/NK Cell Engagers
Part VIII: Logistics
18. Roadmap for Starting an Outpatient Cellular Therapy Program
