Medical research Books

Book Synopsis This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers. It also discusses the current challenges of using immunotherapy for the treatment of gastrointestinal malignancies. The book reviews highly sensitive and specific immunomarkers for the detection of GI malignancies, and examines therapeutic vaccines and the major cytokines involved in GI immunotherapy, as well as their basic biology and clinical applications. In closing, the book explores various aspects of computational biology for the detection and treatment of GI malignancies. Table of Contents1 Tumor heterogeneity: challenges and perspectives for gastrointestinal cancer therapy.- 2 immune composition of gastrointestinal tract of Gut.- 3 Immunomarkers for detection of GI malignancies.- 4 Immuno-therapeutics of gastrointestinal malignancies.- 5 Immune cell therapy against gastrointestinal tract cancers.- 6 Immune checkpoint inhibitors in gastrointestinal malignancies.- 7 Monoclonal Antibody therapy against gastrointestinal tract cancers.- 8 Therapeutic Vaccines for Gastrointestinal Malignancies.- 9 Immuno-Oncology of Oesophageal Cancer.- 10 Association between IL6 gene polymorphisms and gastric cancer risk: A meta-analysis of case-control studies.- 11 Immuno-oncology of colorectal cancer.- 12 Immune targets in colorectal cancer.- 13 Applications of computational biology in gastrointestinal malignancies.

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Book SynopsisThis book examines applications of multi-omics approaches for understanding disease etiology, pathogenesis, host-pathogen interactions. It also analyzes the genetics, immunological and metabolic mechanisms underlying the infections. The book also explores genomics, transcriptomics, translational-omics, and metabolomics approaches to understand the pathogenesis and identify potential drug targets. It reviews the role of epigenetic reprogramming in shaping the host-pathogen interactions and presents bioinformatics application in the identification of drug targets. Further, it examines the potential applications of RNA sequencing and non-coding RNA profiling to identify the pathogenesis. Lastly, it offers the current challenges, technological advances, and prospects of using multi-omics technologies in infectious biology.Table of ContentsChapter 1_Genomic Classification of Human Pathogens. –Chapter 2_Metagenomics of Human Microbiome. –Chapter 3_Genomic Landscape of Novel Coronavirus (2019-Ncov) Towards Better Diagnosis and Efficient Antiviral Therapies. –Chapter 4_Deciphering the Role of Epigenetic Reprogramming In Host-Pathogen Interactions. –Chapter 5_Applications of Next Generation Sequencing In Infectious Pathogens. –Chapter 6_Bioinformatics Applications in Human Pathogens. –Chapter 7_ Non-Coding RNA Profiling: Potential Application in Infectious Diseases. –Chapter 8_ Microarrays: A Road Map to Uncover Host Pathogen Interactions. –Chapter 9_RNA Sequencing as Strategy to Understand Pathogenesis. –Chapter 10_ Non-Coding RNA as Drug Target against Infectious Diseases. –Chapter 11_ Emerging Transcriptional Approach for Identification of Drug Targets in Human Pathogens. –Chapter 12_ Proteogenomics Applications in Human Pathogens.–Chapter 13_Proteomic Strategies for Understanding Host Pathogen Interactions.–Chapter 14_Antimicrobial and Therapeutic Peptides. –Chapter 15_ Structural Proteomics Guided Design of Antimicrobial Drugs and Vaccines. –Chapter 16_Mechanism of Action of Antimicrobial Agents against Clinically Important Pathogens: A Proteomic Approach. –Chapter 17_Application of Lipidomics in Understanding Host Pathogen Interaction. –Chapter 18_Metabolomics: Advances and Applications In Human Pathogens. –Chapter 19_Host-Pathogen Interactions: Nature Inspired Sialic Acid Based Biointerface Materials. –Chapter 20_Nanoparticles as Therapeutic Nanocargos Affecting Epigenome of Microbial Biofilms. –Chapter 21_Challenges and Prospects in Omics Approach to Pathogens

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Book SynopsisThis book provides up-to-date information on the prototypes used to develop medical devices and explains the principles of biosensing and theranostics. It also discusses the development of biosensor and application-orientated design of medical devices. In addition to summarizing the clinical validation of the developed techniques and devices and the regulatory steps involved in their commercialization, the book highlights the latest research and translational technologies toward the development of point-of-care devices in the health care. Lastly, it explores the current opportunities, challenges and provides troubleshooting on the use of biosensors in precision medicine. The book is helpful for researchers and medical professionals working in the field of clinical theranostics, and medical-device development wanting to gain a better understanding into the principles and processes involved in the development of biosensors.Table of ContentsChapter 1_Biosensing: Material, methods and principle of detection.- Chapter 2_Biosensing applications in the development of medical devices.- Chapter 3_Theranostics: basic principles.- Chapter 4_Material and technique advancements in the development of theranostic products.- Chapter 5_Medical device development strategies.- Chapter 6_Research aspects for the development of medical devices.- Chapter 7_Biosensor-based commercialized point-of-care devices.- Chapter 8_Medical devices in clinical set up.- Chapter 9_Clinical validation of medical devices.- Chapter 10_Regulatory steps involved in the validation of medical devices.- Chapter 11_Protocol for registration process of point-of-care device at FDA or equivalent agencies.- Chapter 12_Opportunities and challenges in medical device development.- Chapter 13_Prospective journey of the research idea from laboratory to the user in the clinic.

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Book SynopsisThis book provides deep insight into the significance of various forensic techniques underlying the methodical approaches in criminal investigations. The book comprises numerous case studies, examples, and reference materials. It emphasizes on the better practices for criminal investigations including contemporary examinations. The book also describes various methods for investigation of crime scene and evidence collection including biological evidences to the resources of law enforcement agencies. This book encompasses the procedure for crime scene-documentation through photography, video, and diagrams and highlights the best practices of packaging the biological evidences at a crime scene. Further, it summarizes the role of forensic autopsy to the criminal investigation system. As such, the book is helpful for forensic scientists, medical practitioners, educators and law enforcement personnel.Table of Contents1 Initial response at crime scenes and prioritization of efforts.- 2 Crime scene processing: documentation and evaluation.- 3 Crime Scene Searching: An Exploration of Forensic Evidence.- 4 Collection, Preservation and Packaging: Forensic Evidence Management.- 5 Paint, Soil and Glass Evidences: A Silent Witnesses.- 6 Questioned Document Examination: A Prevalent Dispute.- 7 Medicolegal Examination: A Guide to the Criminal Investigation System.- 8 Examination of Tampered Voice.

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Book SynopsisThis is an open access book. The book provides an overview of the state of research in developing countries – Africa, Latin America, and Asia (especially India) and why research and publications are important in these regions. It addresses budding but struggling academics in low and middle-income countries. It is written mainly by senior colleagues who have experienced and recognized the challenges with design, documentation, and publication of health research in the developing world. The book includes short chapters providing insight into planning research at the undergraduate or postgraduate level, issues related to research ethics, and conduct of clinical trials. It also serves as a guide towards establishing a research question and research methodology. It covers important concepts such as writing a paper, the submission process, dealing with rejection and revisions, and covers additional topics such as planning lectures and presentations. The book will be useful for graduates, postgraduates, teachers as well as physicians and practitioners all over the developing world who are interested in academic medicine and wish to do medical research. Table of ContentsPart 1 Introduction 1 Academic Medicine and the Social Determinants of Health Part 2 Background 2 Why should we publish papers? 3 Overcoming the initial barriers to publication and the role of mentors? 4 When should we start doing research and publishing papers? 5 Does research improve patient care? 6 The status of biomedical research in some developing countries? Part 3 How to plan a study? 7 How to think of a research question? 8 What are the types of study design? 9 How to calculate an adequate sample size? 10 Understanding medical biostatistics 11 Applying biostatistics in medical research 12 Writing the research proposal: the art and the science 13 Ethics in research Part 4 How to write an original research paper? 14 Who should be an Author? 15 How to write an Abstract? 16 How to choose a Title? 17 How to write the Introduction to a scientific paper? 18 How to do a Review of the Literature? 19 How to write Material(Patients) and Methods? 20 How to write Results? 21 How to write the Discussion ? 22 How to Cite other papers and add References? 23 How to add Illustrations? 24 How to check for Plagiarism? 25 How to improve language and syntax in medical writing? Part 5 How to write other journal articles? 26 How to write an Editorial 27 How to write a Letter to the Editor? 28 How to write a Case Report 29 Systematic, Scoping and Narrative Reviews Part 6 After the paper is written 30 To which journal should you submit your article 31 Publication algorithm 32 How to do a Peer Review? 33 How to handle Rejection? 34 Bibliometrics Part 7 What else you should know about publication? 35 Is medical publishing lucrative? 36 How to start a New Medical Journal? Part 8 How to project your work further? 37 How to present a Poster in a conference 38 How to give an Oral presentation? Part 9 Education, planning and execution 39 Bedside teaching in Developing Countries 40 E-learning in the developing world 41 Develop learning objectives and evaluations- Multiple choice questions/ Objective Structured Practical Examination 42 How to prepare a lecture? 43 The Why and How of Problem based learning 44 How to conduct a Journal Club? Part 10 Other topics 45 Medical records 46 Clinical Audit 47 Clinical Drug Trials 48 Ethics in Genetic Testing

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Book SynopsisThe second volume of the Biomedical translational research discusses advancements in biomedical research for understanding the pathophysiology of various diseases towards improving diagnosis and treatment. It presents the integration of molecular-based technologies, clinical genomics, and medical informatics to improve diagnostic and treatment strategies. Further, the book reviews molecular genomics approaches for diagnosis and managing tuberculosis. It also covers the innovative strategies for cancer treatment through targeting metabolic pathways, tumor microenvironment, cancer stem cells, and immune cells. It also illuminates novel strategies for heart failure diagnosis and therapeutic approaches for the treatment of heart failure. It discusses improvements in translational research for discovery of new diagnostic tests, identifying novel biomarkers and drugable targets, and predicting optimal treatments based on understanding the underlying molecular basis of the disease. Lastly, it reviews the preclinical models of restenosis and their application and limitation in the evaluation of device-based interventional technologies for the treatment of coronary artery diseases.Table of Contents Application of clinical genomics in diagnosis and disease treatment Exosomes as novel biomarkers of disease Membrane Lipids: Implication for Diseases and Membrane Trafficking Human natural killer cells and their cytotoxic capacity Molecular genomic approaches for diagnosing and managing tuberculosis Exploring the origin of cancer with stem cell biology Therapeutic potential of skin stem cells in vitiligo Clinical applications of cancer stem cells Immuno therapeutic approaches for cancer treatment Future of uro-oncology Prostate Cancer: Circadian Gene Regulated Malignancy Role of adenosine pathway in cancer Immune modulation and VEGF Modulating tumour microenvironment in the treatment of cancer The endosymbiont role of mitochondria in cancer progression and therapy Interplay of cancer associated fibroblasts and tumour associated macrophages in metastasis Chimeric antigen receptor therapy : A cutting edge therapy for multiple myeloma The future therapies for heart failure Futuristic experimental studies on heart failure and ischemic heart diseases AGE-PAGE Stress in the pathophysiology of atherosclerosis and its treatment Genetics of Left Ventricular Dysfunction in Coronary Artery Disease Gene editing in liver disease Interrupting crystal to calculus conversion : The future of renal stone research Preclinical models of intimal hyperplastic and restenosis for the development of novel therapies Nanoparticles in counteracting multidrug resistant bacterial Rapid eye movement sleep and dream sleep

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Book SynopsisThe book titled ‘Prebiotics, Probiotics and Nutraceuticals’ is expected to direct many emerging research pathwaysneed at local and global levels for nutrition and food supplements for developing immunity for healthy life. This volume incorporates sixteen seminal papers on issue based research and their practical applications covering latest information and progress on different area of nutritional supplement research fight against disease. The book highlights the frontier issues and applications in nutritional biotechnology with wide coverage of the themes like Potentiality of Probiotics in Inactivation of Tetrodotoxin, Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics and Prospectives of Prebiotics, Probiotics and Synbiotics for Sustainable Development in Aquaculture.Plant based Bioactive compounds in Cancer Therapeutics, Recent Trends in Natural Medicines and Nutraceuticals Research, Probiotics as efficacious therapeutic option for treating gut-related diseases: molecular and immune-biological perspectives, The progressive development of probiotics, prebiotics, synbiotics research, and its multipurpose use in the ornamental fishery, The commercial perspective of probiotics, and bioremediating components in aquaculture pond management: A Case Study andPrebiotics as promising therapeutics for treating gut-related disorders : Biochemical and Molecular Perspectives. Prebiotics and Probiotics as Functional Foods: Prospect and Promises in Metabolic Diseases, Implications of probiotics and prebiotics on immune functions. Recent Trends in Natural Medicines and Nutraceuticals Research, Nutraceuticals are alternative to modern medicines, Socio-Economic Study of Prospective of probiotic, prebiotic and synbiotic for sustainable development of aquaculture in Indian Sunderban. This book will be very useful for the scholars, biotechnologists, agricultural scientists, nutritionist, medical doctors, researchers, teachers and students in the emerging field of biotechnology.Table of Contentsa. Advances in Microbial Fermentation and Fermented Food product for Health b. Application of Computational Intelligence Techniques for in Prebiotics, Probiotics, and Nutraceuticals. c. Advances in Genetic Engineering technologies leading to the development of Prebiotics, Probiotics, and Nutraceuticals. d.The Commercial Perspective of Prebiotics, Probiotics, and Nutraceuticals components. e. Innovative technologies linked with the Prebiotics, Probiotics and associated elements. f. Benefits of Probiotics components and effects in immunological purposes. g. Emerging prospects and challenges of Probiotics and Prebiotics to human health. h. Wild edible plants the rich source of Nutraceuticals i. Probiotics Microbes and Biomedical Applications j. Marine Probiotics and Prebiotics for therapeutic application k. Recent Trends in Natural Medicines and Nutraceuticals Research l. Prospective of Probiotic, Prebiotic and Synbiotic for sustainable development of aquaculture

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Book SynopsisThis book provides an up-to-date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases. Focusing on the sphingolipid de novo synthesis pathway, the effect of sphingomyelin, ceramide, and sphingosine-1-phosphate, and linkage between sphingolipids and other lipids, such as cholesterol, it covers serine palmitoyltransferase, ceramide synthases, ceramidases, sphingosine kinases, and sphingomyelin synthases, and more. While highlighting how rare diseases related to abnormal glycosphingolipid metabolism, this publication introduces sphingolipid metabolism-related diseases, such as lung diseases and cancers, as well as sphingolipid circadian regulation. The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases. It offers graduate students and researchers a coherent overview of sphingolipids, as well as the limitations of current research in the field, and promotes further studies on metabolic diseases, as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase.Table of ContentsChapter 1: Sphingolipids and Cholesterol.- Chapter 2: Sphingolipids in adipose: kin or foe?.- Chapter 3: De novo sphingolipid biosynthesis in atherosclerosis.- Chapter 4: Serine Palmitoyltransferase Subunit 3 and Metabolic Diseases.- Chapter 5: Molecular mechanisms of sphingolipid transport on plasma lipoproteins.- Chapter 6: Sphingosine 1-phosphate metabolism and signaling.- Chapter 7: Sphingomyelin synthase family and phospholipase Cs.- Chapter 8: Sphingolipid metabolism and signaling in endothelial cell functions.- Chapter 9: Cholesterol metabolism in chronic kidney disease: physiology, pathologic mechanisms, and treatment.- Chapter 10: Sphingolipids and asthma.- Chaper 11: Manifold Roles of Ceramide Metabolism in Nonalcoholic Fatty Liver Disease and Liver Cancer.- Chapter 12: Drug development in the field of sphinogolipid metabolism.- Chapter 13: Rare diseases in glycosphingolipid metabolism.

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Book SynopsisThis book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.Table of ContentsChapter 1. A Historical and Technological Background to Organs-on-a-Chip.- Chapter 2. Applications of microfluidics.- Chapter 3. Microfluidics based Organ-on-a-chip for cell biology studies.- Chapter 4. Microfluidics in Chemical biology.- Chapter 5. Role of microfluidics in drug delivery.- Chapter 6. Microfluidics in drug discovery.- Chapter 7. Microfludic based sensors.- Chapter 8. Background and Organs-on-a-Chip.- Chapter 9. Culture and co-culture of cells for multi organ on chip.- Chapter 10.Cells and organs on a chip in biomedical sciences.- Chapter 11. Futuristic aspects of organ on a chip.- Chapter 12. Development of Human on a chip.- Chapter 13. Multi-organ on a chip for personalized medicine.- Chapter 14. Development and application of Microfluids in organoid formation.- Chapter 15. Liver on a chip.- Chapter 16. Placenta on Chip: A Modern approach to probe feto-maternal interface.- Chapter 17. Microfluidic retina-on-chip.- Chapter 18. Heart on a chip.- Chapter 19. Kidney on a chip.- Chapter 20. Lungs on a chip.- Chapter 21. Brain on a chip.- Chapter 22. Skin on a chip.- Chapter 23. Organs-on-a-chip in preclinical studies.- Chapter 24. Application of organ on chip in blood brain barrier model.- Chapter 25. Multi organs on a chip in disease modeling.- Chapter 26. Prospects of Medical device on a chip.- Chapter 27. Lab on a chip for precision Medicine.- Chapter 28. Tumour-on-a-chip : Perfusion systems to model the extracellular breast tumour microenvironment:from tumour progression to metastasis formation.- Chapter 29. Building Human In Vitro 3D Models to Replace Animal Studies: During Drug Discovery Reearch: Scientific, Ethical and Regulatory Considerations.

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Book SynopsisRecurrent Miscarriages (RM) & Implantation Failure (IF) have remained an enigma to clinicians and researchers. Even after ruling out all possible causative factors, 50-60% cases still remain “Unexplained’. A majority of these so called “Unexplained” cases are now found to have immunological basis.This book is going into the Immunological aspects of these clinical dilemmas, demystifying the role of Immunology and Immunotherapy in RM and IF. The authors have been working in the field of Reproductive Immunology and Immunotherapy for the last 25 years and they have come out with this book combining the international studies with their own experience. The purpose of writing this book is to provide a comprehensive treatise about Immunotherapy, so that it can become an acceptable modality of treatment in cases where it is needed and is effective.The book discusses the basics in Reproductive Immunology. The immunological changes occurring during pregnancy, the role of Cell mediated Immunity (T cells), Humoral Immunity including cytokines is explained. The normal immunological mechanisms protecting the embryo are highlighted and how these mechanisms are disturbed leading to RM and IF, is also explained.The first and the most discussed method of Immunotherapy is Lymphocyte Immunization Therapy (LIT). The book has given a complete overview of LIT, describing how it created euphoria when it was first introduced, how it gradually went into disrepute and how it is now making a comeback. As the authors have personal experience of LIT, the book gives a detailed and complete information about this active form of immunotherapy.The book has a special section on case studies where the authors have given some clinical case reports (including some of their own), who were treated for immunological factor in RM/IF and were treated with Immunotherapy. These cases can be a useful guide to the readers.The book will be useful not only for undergraduate and postgraduate students but also for clinicians in their practice and for researchers for review of developments in the field.Table of ContentsPart I.- Chapter 1: Introduction.- Chapter 2: Recurrent Pregnancy Loss and Recurrent Implantation Failure.- Chapter 3: Immune System.- Chapter 4: Immunology of Pregnancy (Reproductive Immunology) .- Chapter 5: Diagnosis of Alloimmune factor.- Part II.- Chapter 6: Introduction.- Chapter 7: History of LIT.- Chapter 8: Mechanism of Action of LIT.- Chapter 9: Procedure of LIT.- Chapter 10: Safety of LIT.- Chapter 11: Controversies about LIT – REMIS Study.- Chapter 12: Cochrane Reviews & LIT.- Chapter 13: Recent Meta-analyses & LIT.- Chapter 14: Review of International studies of LIT.- Chapter 15: Case Studies.- Chapter 16: Future of LIT.

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Book SynopsisThis book offers a comprehensive exploration of malaria, a life-threatening disease affecting millions globally, with a focus on the parasitic organisms of the genus Plasmodium that cause it.

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Book SynopsisThis book provides the reader with a thorough understanding of schizophrenia as a complex brain disorder by explaining the various aspects investigated for its cognizance from epigenetics to chemistry and physics to computational approaches. The book covers the key notions of schizophrenia from a variety of facets such as neurogenetics, neurochemistry, neuropharmacology, neurobiology, psychotherapy, psychiatric treatment, cognitive studies, behavioral and societal studies, and computational neurosciences. Individual chapters are focused on crucial topics such as cognitive-behavioral therapy, brain functioning, computational neuroscience, neuro-imaging, and many more. This book explains each section and chapter with utmost clarity to maintain comprehensiveness for every kind of reader. This book covers various classical as well as recent topics from basic to advance level knowledge regarding schizophrenia. The book's contributions regarding its inclusivity of topics, comprehensiveness of language, diversity in knowledge, and focus on the subject will attract all kinds of readers. It can be considered a single comprehensive handy reference book for beginners, including medical students, neuroscientists, researchers, clinicians, and medical practitioners. Cognizance of Schizophrenia will be an invaluable asset for all who are involved in neuroscience research or clinical studies.Table of Contents Understanding schizophrenia: introductory aspect of the mental disorder from various perspectives Genetic mutations and Alternative splicing in schizophrenia Understanding the Chemical Interactions in the Brain of Schizophrenia Patients A diagnostic perspective of schizophrenia: from past to present Is it schizophrenia or not? - Different Biological characterization A neurobiological aspect of schizophrenia and the relationship between neurological disorders: depression, anxiety, epilepsy Clinical treatment available for schizophrenia Insights into the neuro-pharmacological treatment of schizophrenia: past, present, and future Managing Schizophrenia – A Challenge for Physicians Pharmacotherapy and Emerging Treatment Strategies for Schizophrenia Alternative Therapies used in Schizophrenia Different phases of schizophrenia patients: from the psychological perspective Stigmatizing Attitudes Towards Patients with Schizophrenia Among Medical Professionals and General Population Rehabilitation of Schizophrenia-Practical Interventions Consumption of Cannabis: A risk factor or a therapeutic agent for patients with Schizophrenia Medical Imaging and Schizophrenia: A Study on State-of-art Applications Schizophrenia and its Effect on Marital Satisfaction The mortality rate in schizophrenia

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Book SynopsisThis book elucidates the role of microbial genomic islands (GEIs) in genome stability, plasticity, evolutionary adaptation, and pathogenicity in the bacterial population. The initial chapters of the book present tools, including bioinformatics, artificial intelligence, machine learning, next-generation sequencing, and molecular biology techniques, for the analysis of the genomic islands. The book also discusses the importance of genomic islands in bacterial speciation, acquisition of genes related to resistome, nitrogen fixation, mobilomes, and nutritional fitness and adaptation. It provides recent advances in understanding microbial genomic islands' distribution, evolution, and mechanistic modes of behavior in pathogenic, non-pathogenic, and environmental species. This book is a valuable source for beginners in molecular microbiology, students, researchers, clinicians, stakeholders, and policymakers interested in understanding the role of GEIs in the adaptive evolution of microorganisms. ​Table of ContentsChapter 1. An introduction of microbial genomic islands for evolutionary adaptation and pathogenicity.- Chapter 2. Computation tools for prediction and analysis of genomic islands.- Chapter 3. An overview of genomic islands’ main features and computational prediction: the CMNR group of bacteria as a case study.- Chapter 4. Microbial genomic island discovery, visualization and analysis.- Chapter 5. Genomic islands in bacterial genome evolution and speciation.- Chapter 6. Genomic islands in the gut microbiome: current knowledge and the application in the probiotics field.- Chapter 7. Genomic islands in nutritional fitness and adaptation.- Chapter 8. Genomic islands involved in iron uptake.- Chapter 9. Genomic islands in uropathogeneic E. coli.- Chapter 10. Genomic islands in Helicobacter species.- Chapter 11. Genomic islands in Staphylococcus.- Chapter 12. Genomic islands in Pseudomonas species.- Chapter 13. Genomic islands in Klebsiella pneumonia.- Chapter 14. Molecular Insights into Genomic Islands and Evolution of Vibrio cholerae.- Chapter 15. Genomic islands in marine bacteria.- Chapter 16. Challenges in Eventing Horizontal Gene Transfer.- chapter 17. Artificial Intelligence and machine learning for prediction and analysis of genomic islands. ​

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Book SynopsisMachine Learning based Classification of Early and Late Mild Cognitive Impairment Conditions using Structural MR Images of Fornix and Geometric Features.- A study on extraction of pectin from citrus fruits and its therapeutic implications.- Aromatic π – π Interactions in Self-assembled Nanostructured Materials.- In-silico and in-vivo evaluation of synthesized ursolic acid derivative as anti-hyperlipidemic agent.- Development of Electronic Tongue (e-tongue) Based Technique for Classification of Dairy Products.- Molecular cloning, expression, and generation of UPF3B-3'UTR stable expression mammalian cell line.- Anti-Oxidant Assays in Biological Fluids and Their Potential for Detection of Diseases.- Phytochemical profile, antioxidant and antimicrobial potential of the extract    of various Curcuma spp. from Manipur.- Use of dopant-free vanadium oxide (V2Ox) as hole selective layer while fabrication of single side silicon heterojunction solar cell.- Study of the Effective Electron Neutrino Mass of the Neutrino Mass Matrix with Vanishing Trace and One Vanishing Minor.- Advanced Porous Carbon Aerogels for High-Performance Energy Storage Applications.- Lane formation in 3D Pair-Ion Plasmas: effect of magnetic field and time varying nature of non-parallel electric field.- Rapid and Cost-Effective In situ Fabrication of Nanoporous Membranes in Microfluidic Devices for Biomedical and Environmental Applications.- etc.

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Book SynopsisThe book, intended for biomedical researchers, attempts to foster a comprehensive understanding of the elements that impact scientific research, such as clinical trial design, communication, and publication methods. It introduces the process of idea generation and creative/critical thinking, leading to the development of key concepts that coalesce into theoretical constructs and working hypotheses. The book systematically delineates research phases associated with a bench-to-bedside translational approach, providing the full depth and breadth of drug discovery and development: design, synthesis, and optimization of drug candidates interacting with targets linked to diseases, as well as clinical trial design to acquire substantial evidence of efficacy and safety for candidate drugs in the target patient population. New and evolving topics such as artificial intelligence, machine and deep learning, drug repurposing approaches, and bioinformatics, are incorporated into the text as these features are becoming integrated into drug research and development. Additionally, it covers publication strategies, including literature search, manuscript preparation, data presentation, relevant discussion, editorial processes, elements of peer review, and bibliometrics. Finally, the book addresses grantsmanship, key strategies for building effective networks, mentorships, maintaining research integrity, and forging career advancement opportunities, including entrepreneurship.Table of ContentsPlease refer to the attachments tab.

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Book SynopsisThe book gives an insight into the theoretical background, conceptual understanding, latest developments, and applications in the field of pharmaceuticals in general and drug design, discovery, biosystems, and biomedical and drug delivery technologies in particular. Knowledge is drawn from various disciplines such as Chemistry, Biology, Material Science and Engineering, Statistics, Biomedicine, and Genetics . A host of applications like bio-imaging, novel biological agents, testing, characterization and validation of drugs, computer-based models in drug design, and application of statistical tools in data analysis, design, and development of drug delivery systems, and ecosystems are dealt with in detail. The said book undoubtedly confirms the requirements of the postgraduate students, research scholars, academicians, scientists, and researchers from the academia, pharmaceutical, biotechnology, and chemical engineering domain. The book covers a conceptual understanding of the exploration of drugs in tandem with intended uses, sound ecosystem development, and carriers for drug and supplement delivery.Table of ContentsChapter 1. Editorial: Biosystems.- 2. Potential of Biotechnology in cancer management.- 3. Biosimilars: Promising and Rapidly Emerging Biotherapeutics.- 4. Applications of Nanomaterials in Medicine: Current status and future scope.- 5. Biomedical Applications of Nanofluids in Drug Delivery.

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Book SynopsisThis book provides a comprehensive review of the latest advances in translational pain and itch research, and presents the cutting-edge developments in the study of our two principal, yet most mysteries sensations. Despite the slow progress in the discovery of effective therapies for chronic pain and pruritus, scientists around the globe now have a better understanding of why and how these conditions occur. Based on these findings, a series of novel treatment strategies are currently under development, and hopefully in a few years, medical practitioners will become more confident and optimistic when facing patients with these annoying and sometimes severe disorders. The contributing authors are world-renowned research scientists, who have made significant discoveries. The book is of interest to neuroscientists, neurologists and pharmacologists in both clinical and basic medical research field. In this second edition of the book, five existing chapters have been updated. Five new chapters have been added to reflect the lasted developments in the related field of research.Table of ContentsChapter 1 Assessment of Itch and Pain in Animal Models and Human Subjects.- Chapter 2 Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse.- Chapter 3 Modulation of C-nociceptive Activities by Inputs from Myelinated Fibers.- Chapter 4 Pathophysiologic basis of the treatment of spontaneous pain.- Chapter 5 Neuropathic Pain: Sensory Nerve Injury or Motor Nerve Injury?.- Chapter 6 T cell and subsets in neuropathic pain.- Chapter 7 Astrocyte and microglia in chronic postsurgical pain.- Chapter 8 Dorsal spinal modulation of neuraxial opioids induced pruritus.- Chapter 9 Peripheral Nociceptors as Immune Sensors in the Development of Pain and Itch.- Chapter 10 Mas-Related G Protein-Coupled Receptors Offer Potential New Targets for Pain Therapy.- Chapter 11 Pain Modulation and the Transition from Acute to Chronic Pain.- Chapter 12 Integrated, Team-Based Chronic Pain Management: Bridges from Theory and Research to High Quality Patient Care.- Chapter 13 Research progress of long-acting analgesics for the treatment of chronic pain.- Chapter 14 Update in the Treatment of Neuropathic Pain.- Chapter 15 Mechanisms of peripheral sensitization in neuropathic pain.

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Book SynopsisThis book reviews the etiology of major zoonotic diseases, their impact on human health, and control mechanisms for better management. It also examines factors influencing transmission, diagnosis, treatment, management, and prevention of zoonotic diseases caused by different human pathogens, including bacteria, viruses, fungi, protozoans, and parasites. It also introduces zoonoses with a wildlife reservoir and discusses different transmission modes, and factors that influence the epidemiology of zoonoses. It further discusses the holistic strategies for the cost-effective prevention and control of these zoonoses. Towards the end, the book also discusses infections that have spread from non-human primates to humans and strategies to improve disease control and elimination. This book is very useful for students, academicians, and researchers of veterinary sciences, veterinary medicine, and, veterinary public health.Table of Contents ) Chapter 1- ZOONOSES • Definition • Classification • Origin, emergence and re-emergence of zoonoses • Evolution of methods of managing/controlling zoonoses 2) Chapter 2-VIRAL ZOONOSES A) Human to human transmission (1-129) 1. Ebola 2. Marburg 3. SARS -1 4. MERS 5. SARS-2 6. Dengue 7. Chikungunya 8. Zika 9. Yellow Fever B) TRANSITION -TO ZOONOTIC VIRUSES 10. Influenza viruses- some basics a. Evolution- antigenic shift, host switching b. The Hong Kong (H5N1) virus 1997 c. Avian influenza d.H7N9 e. H1N1 f. H3N2 11. Nipah Chapter 3- Mosquito borne viruses 1. Japanese Encephalitis 2. St. Louis encephalitis 3. EEE 4. WEE 5. Australian Encephalitis 6. Ross River 7. WN-Kunjin 8. California, La Crosse 9. Rift Valley Fever 10. West Nile 11. O’ Nyong Nyong 12. Colorado Tick fever 13. Powassan virus 14. Kyasanur Forest Disease 15. Crimean Congo Haemorrhagic Fever VIRAL ZOONOSES (1-72) 1. Hanta 2. Rabies 3. RVF Chapter 4- BACTERIAL ZOONOSES 1. Anthrax 2. Anaplasmosis: A phagocytophilum 3. Bartonellosis • Bacillary angiomatosis (BA): B. henselae and B. quintana • Cat scratch fever/disease (CSF/CSD): B. henselae, B. clarridgeiae • Oroya Fever or Carrion’s disease: B. bacilliforms • Trench fever: B. quintana 4. Ehrlichiosis: E.chaffeensis; E. ewingii; E. canis, Neorickettsia sennetsu and recently described Panola mountain Ehrlichia species genetically closely related to E. ruminantium 5. Borreliosis 6. Lyme Disease: B. burgdorferi sensu lato 7. Southern Tick-Associated Rash Illness (STARI) or Masters’ disease: B. lonestari 8. Louse borne relapsing fever: B. recurrentis 9. Tularemia: Francisella tularensis 10. Q fever 11. Leptospirosis 12. Glanders 13. Mycobacteriosis -Part 1 Classical tuberculosis 14. Mycobacteriosis - Part 2 Zoonotic mycobacteriosis 15. Plague 16. Brucellosis Chapter 5- CHLAMYDIAL AND RICKETTSIAL ZOONOSES 1. Rocky Mountain Spotted fever 2. Indian tick typhus 3. African tick typhus 4. Scrub typhus-O. tsutsugamushi 5. Murine (Epidemic) typhus 6. Rickettsial pox – R. akari Chapter 6- MYCOTIC ZOONOSES Introduction Mycotoxicosis Aspergillosis Blastomycosis Candidiasis Coccidioidomycosis Cryptococcosis Dermatomycosis Histoplasmosis Mucoromycosis Rhinosporidiosis Sporotrichosis Chapter 7-Parasitic zoonoses Epidemiology of parasitic zoonoses A) PROTOZOAL ZOONOSES Trypanosomiasis Amoebiasis Babesiosis Chagas ’ disease Cryptosporidiosis Giardiasisis Leishmaniasis- Cutaneous & Visceral Sarcocystosis Toxoplasmosis B) HELMINTHIC ZOONOSES 1. Trematodiases Epidemiology of fish borne trematodiasis Clonorchiasis Dicroceliasis Echinostoma Fascioliasis Gastrodiscoidiasis Intestinal flukes- Fasciolopsis buski Heterophyiasis Opisthorchiasis Paragonimiasis-Lung fluke 2. Cestodiases Coenurosis Cysticercosis Diphyllobothriasis Dipylidiasis Dipylinum caninum Hydatidosis Taeniasis Rallietina spp. Sparagonosis Hymenolpiasis 3. Nematodiases Fish-borne nematodiasis Ancylostomiasis Anisakiasis Angiostrogylosis Capillariasis Dracunculiasis Gnathostomiasis Larva Migrans Schistosomiasis Trichinellosis Trichostrongylus Toxocariasis Chapter 9- Ectoparasites Louse borne diseases Tick paralysis Zoonotic ectoparasites Chapter 10-Wildlife as Reservoir of Zoonoses • Introduction • Opportunities of contact and transmission • Preventive measures • Preventing wildlife originated zoonoses Chapter 11-Non-human primates as reservoir Chapter 12-Rodents as Reservoir Chapter 13-Bat- natural reservoir of zoonotic viruses Chapter 14-Vectors as carrier of zoonoses ​

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Book SynopsisReal-world evidence (RWE) has been at the forefront of pharmaceutical innovations. It plays an important role in transforming drug development from a process aimed at meeting regulatory expectations to an operating model that leverages data from disparate sources to aid business, regulatory, and healthcare decision making. Despite its many benefits, there is no single book systematically covering the latest development in the field.Written specifically for pharmaceutical practitioners, Real-World Evidence in Drug Development and Evaluation, presents a wide range of RWE applications throughout the lifecycle of drug product development. With contributions from experienced researchers in the pharmaceutical industry, the book discusses at length RWE opportunities, challenges, and solutions.Features Provides the first book and a single source of information on RWE in drug development Covers a broad array of topics on outTable of Contents1 Using Real-world Evidence to Transform Drug Development: Opportunities and Challenges. 2. Evidence derived from real world data: utility, constraints and cautions. 3. Real-World Evidence from Population-Based Cancer Registry Data. 4. External Control using RWE and Historical Data in Clinical Development. 5. Bayesian method for assessing drug safety using real-world evidence. 6. Real-World Evidence for Coverage and Payment Decisions. 7. Causal Inference for Observational Studies/Real-World Data. 8. Introduction to Artificial Intelligence and Deep Learning with a Case Study in Analyzing Electronic Health Records for Drug Development.

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Book SynopsisThe second volume in the CURRENT TOPICS IN NONCLINICAL DRUG DEVELOPMENT SERIES explores the critical issues and current topics in nonclinical drug development. This second volume covers individual topics and strategies in drug development from compound characterization to drug registration. Written by a variety of experts in the field, recent and rapid advances in technologies and associated changes in regulatory guidance are discussed.Select topics include: Evolution of Artificial Intelligence (AI) technologies and the impact on toxicologic pathology. Current approaches to carcinogenicity testing. Predicting drug-drug interactions. Current understanding of idiosyncratic drug reaction. Assessing cardiovascular risks beyond QT interval. Use of 3D cell cultures in toxicology and ADME. Development of small molecule-antibody complexes. Differentiating adverse from non-adverse findings in nonclinical studiesTable of Contents1. Introduction and History of Digital Toxicologic Pathology 2. Carcinogenicity Testing of Human Pharmaceuticals 3. Differentiating Adverse and Non-adverse Findings in Nonclinical Studies 4. Current Understanding of Idiosyncratic Drug Reactions 5. Three-Dimensional Cell Culture Models in Toxicology and ADME 6. Assessing Cardiovascular Risk Beyond the hERG Channel and the QT Interval 7. Fundamentals of Drug-Drug Interactions 8. Development of Small Molecule-Antibody Complexes

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Book SynopsisMeta-analysis is the application of statistics to combine results from multiple studies and draw appropriate inferences. Its use and importance have exploded over the last 25 years as the need for a robust evidence base has become clear in many scientific areas, including medicine and health, social sciences, education, psychology, ecology, and economics.Recent years have seen an explosion of methods for handling complexities in meta-analysis, including explained and unexplained heterogeneity between studies, publication bias, and sparse data. At the same time, meta-analysis has been extended beyond simple two-group comparisons of continuous and binary outcomes to comparing and ranking the outcomes from multiple groups, to complex observational studies, to assessing heterogeneity of effects, and to survival and multivariate outcomes. Many of these methods are statistically complex and are tailored to specific types of data.Key featuresRigorous coverage of tTrade Review"Handbook of Meta-Analysis is a most laudable and detailed treatise on meta-analysis. It successfully covers – with gusto and substance – the full range of statistical methodology used in meta-analysis in a statistically rigorous and up-to-date manner, exuding a good balance of theory and applications (with real data and software syntax provided). It provides a comprehensive, coherent, and unified overview of the statistical foundations behind meta-analysis. Crafted by experts on the topic, each chapter is written with lucidity and surgical precision. It is elegantly organized, encyclopedic in breadth and depth, and fluent in exposition on the multidimensional role of meta-analysis: core material (background, systematic review process, data extraction, study-level results, frequent and Bayesian approaches); key extensions (meta-regression, individual data, multivariate meta-analysis, network meta-analysis, model checking, bias); and advances in particular fields of biomedical and social research (control risk regression, survival data, correlation matrices, genetic data, dose-response relationships, diagnostic tests, surrogate endpoints, complex observational data, prognostic models). It is a tour de force, a premier, and an indispensable reference that is highly recommended – and a must for serious researchers and practitioners engaged in meta-analysis. This state-of-the-science handbook is destined to be a classic."- Joseph C. Cappelleri, PhD, MPH, MS, Executive Director of Biostatistics, Pfizer Inc "For many researchers in social, medical, life and environmental sciences, it has become an essential part of their activities to synthesize evidence from the body of relevant research. The Handbook of Meta-analysis provides the most comprehensive and up-to-date coverage of the quantitative part of evidence synthesis, i.e., meta-analysis. Therefore, this handbook is a must-have for all researchers who wish to unlock and understand the power and potential of meta-analysis, but also for those who have already found and benefited from it. The authors of this edited volume are an interdisciplinary all-star team of statisticians and methodologists; probably, each of them could have written a textbook on meta-analysis. Here, they introduce both basics and advanced techniques that they have been leading to develop over their career. For many statisticians, a meta-analysis may be just one type of linear models (Chapters 1-11), yet, as this book demonstrates, meta-analyses can come in diverse forms and serve different purposes (see Chapters 14-22). Further, there are specific statistical issues meta-analysis needs to grapple with, such as publication bias (Chapters 12-13). The book ends with a chapter on how to use meta-analysis to plan our future work (Chapter 23) – what all scientists should be doing to reduce research waste and to accelerate scientific progress."- Shinichi Nakagawa, Professor of Evolutionary Biology and Synthesis, University of New South Wales, Sydney, Australia "This is an important book on an important subject, covering both theory and application, and it should be valuable to a wide range of readers in statistics and applied fields."- Andrew Gelman, Columbia University "...The Handbook of Meta-Analyses is a “must have” resource for: 1) statisticians, other professionals, and students conducting statistical research in meta-analysis; 2) practitioners conducting meta-analyses as part of systematic reviews or otherwise; and 3) educators and students who want to either start, or continue, to learn more about meta-analysis. The breadth and depth of up-to-date coverage of meta-analysis methods, wide range of areas of application, and examples, including online software code and data, is impressive. The contents are weighted towards frequentist strategies, but Bayesian strategies are highlighted in the core materials and revisited elsewhere. The Handbook is a pleasure to read. The editors and other co-authors guide the reader in a cohesive, unified fashion, from the foundational core material through increasingly sophisticated and wider ranging methods and applications. Their tone is conversational, with forwards-and-backwards sign-posting which integrates the contents in a tutorial-like fashion. Statistical notation is used with purpose, without excess, while maintaining statistical rigor in content. An abundance of graphs, figures, and tables reinforce the statistical concepts and methods, and visualize the examples. Both novice and more experienced readers will benefit...The Handbook of Meta-Analysis is a significant contribution which provides a palpable opportunity to improve future decision-making and policy setting."- Thomas Bradstreet, Appeared in the Journal of Biopharmaceutical Statistics "The handbook is intended for a relatively wide audience of statisticians, to be used as a textbook in a graduate course, as a reference book, a handbook or an introduction. The first part easily accomplishes these aims. There is a fair number of formulas, but they are well-explained and thus the text should be accessible for any statistician or quantitative researcher." -Anikó Lovik, International Society for Clinical Biostatistics, 72, 2021 Table of Contents1. Introduction to systematic review and meta-analysis2. General themes in meta-analysis3. Choice of effect measure and issues in extracting outcome data4. Analysis of univariate study-level summary data using normal models5. Exact likelihood methods for group-based summaries6. Bayesian methods for meta-analysis7. Meta-regression 8. Individual participant data meta-analysis9. Multivariate meta-analysis10. Network meta-analysis11. Model Checking in meta-analysis12. Handling internal and external biases: quality and relevance of studies13. Publication and outcome reporting bias14. Control risk regression15. Multivariate meta-analysis of survival proportions16. Meta-analysis of correlations, correlation matrices and their functions17. The meta-analysis of genetic studies18. Meta-analysis of dose-response relationships19. Meta-analysis of diagnostic tests20. Meta-analytic approach to evaluation of surrogate endpoints21. Meta-analysis of epidemiological data, with a focus on individual participant data22. Meta-analysis of prediction models23. Using meta-analysis to plan further research

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Book SynopsisDrawing on the knowledge and experiences of world-renowned scientists and healthcare professionals, this important book brings together academic, medical and health systems accounts of the impact of applying qualitative research methods to transform healthcare behaviours, systems and services. It demonstrates the translation of tried-and-tested and new interventions into high-quality care delivery, improved patient pathways, and enhanced systems management. It melds social theory, health systems analysis and research methods to address real-life healthcare issues in a rich and realistic fashion. The systems and services examined include those affecting patient care and patient and professional wellbeing, and the roles and responsibilities of people providing and receiving care. Some chapters delve deeply into the human psyche, examining the very private face of health and illness. Others concentrate on public health and how people's needs can be met through healthTable of ContentsPart 1 Ideas 1.Introduction:Why this book 2.Qualitative Evidence Synthesis and Conceptual Development 3.The Life-Project of personal Wellbeing: Modern Healthcare and the Individuality of Health 4.Socio-Narratology and the Clinical Encounter Between human Beings 5.Interrupted Body Projects and the Narrative Reconstruction of Self 6.The Fourth Research Paradigm: Activating Researchers for Real World Need Part 2 Systems 7.Slack Resources in Healthcare Systems: Waste or Reslilance? 8.Using Qualitative Methods to Understand Resiliance in Complex Systems 10.Narrativising Cancer Patients' Longitudinal Experiences of Care: Qualitative Inquiry into Lived and Online Melanoma Stories 11.Look the Other Way: Patient-Centred Care Begisn with Care for Our Physicians 12.Resilient Healthcare in Refractory Epilepsy: Illuminating Successful People-Centred Care Part 3 Solutions 13.Sensemaking as a Strategy for Managing Uncertainty: Change and Surprise in Hospital Settings 14.Simulation to Solve Health System Problems 15.Cross-Boundary Teaming to Establish Resiliance Among Isolated 'Silos' 16."What on Earth is Going on and What Should I Do Now?" Sensemaking as a Qualitative Process 17.Deep Inside the Genomics Revoltion: On The Frontlines of Care 18.Much More Than Old Wine in New Bottles: Soft Systems Methodology (SSM) for healthcare improvement 19.Conclusion: On progress, directions and signposts to a transformed healthcare system

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