Description

Book Synopsis

The second volume in the CURRENT TOPICS IN NONCLINICAL DRUG DEVELOPMENT SERIES explores the critical issues and current topics in nonclinical drug development. This second volume covers individual topics and strategies in drug development from compound characterization to drug registration. Written by a variety of experts in the field, recent and rapid advances in technologies and associated changes in regulatory guidance are discussed.

Select topics include:

  • Evolution of Artificial Intelligence (AI) technologies and the impact on toxicologic pathology.
  • Current approaches to carcinogenicity testing.
  • Predicting drug-drug interactions.
  • Current understanding of idiosyncratic drug reaction.
  • Assessing cardiovascular risks beyond QT interval.
  • Use of 3D cell cultures in toxicology and ADME.
  • Development of small molecule-antibody complexes.
  • Differentiating adverse from non-adverse findings in nonclinical studies

    Table of Contents

    1. Introduction and History of Digital Toxicologic Pathology 2. Carcinogenicity Testing of Human Pharmaceuticals 3. Differentiating Adverse and Non-adverse Findings in Nonclinical Studies 4. Current Understanding of Idiosyncratic Drug Reactions 5. Three-Dimensional Cell Culture Models in Toxicology and ADME 6. Assessing Cardiovascular Risk Beyond the hERG Channel and the QT Interval 7. Fundamentals of Drug-Drug Interactions 8. Development of Small Molecule-Antibody Complexes

Current Topics in Nonclinical Drug Development

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    £166.25

    Includes FREE delivery

    RRP £175.00 – you save £8.75 (5%)

    Order before 4pm tomorrow for delivery by Sat 27 Jun 2026.

    A Hardback by Philip Bentley, Pritam S. Sahota, Zbigniew Wojcinski

    15 in stock


      View other formats and editions of Current Topics in Nonclinical Drug Development by Philip Bentley

      Publisher: Taylor & Francis Ltd
      Publication Date: 11/9/2023 12:00:00 AM
      ISBN13: 9780367466688, 978-0367466688
      ISBN10: 0367466686
      Also in:
      Medical research Pharmacology

      Description

      Book Synopsis

      The second volume in the CURRENT TOPICS IN NONCLINICAL DRUG DEVELOPMENT SERIES explores the critical issues and current topics in nonclinical drug development. This second volume covers individual topics and strategies in drug development from compound characterization to drug registration. Written by a variety of experts in the field, recent and rapid advances in technologies and associated changes in regulatory guidance are discussed.

      Select topics include:

      • Evolution of Artificial Intelligence (AI) technologies and the impact on toxicologic pathology.
      • Current approaches to carcinogenicity testing.
      • Predicting drug-drug interactions.
      • Current understanding of idiosyncratic drug reaction.
      • Assessing cardiovascular risks beyond QT interval.
      • Use of 3D cell cultures in toxicology and ADME.
      • Development of small molecule-antibody complexes.
      • Differentiating adverse from non-adverse findings in nonclinical studies

        Table of Contents

        1. Introduction and History of Digital Toxicologic Pathology 2. Carcinogenicity Testing of Human Pharmaceuticals 3. Differentiating Adverse and Non-adverse Findings in Nonclinical Studies 4. Current Understanding of Idiosyncratic Drug Reactions 5. Three-Dimensional Cell Culture Models in Toxicology and ADME 6. Assessing Cardiovascular Risk Beyond the hERG Channel and the QT Interval 7. Fundamentals of Drug-Drug Interactions 8. Development of Small Molecule-Antibody Complexes

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