Cellular biology (cytology) Books
Nova Science Publishers Inc Stem Cells Origins of Cytokine Interactions
Book SynopsisCD34+ pluripotent hematopoietic stem cells (HSCs) are generally involved in all aspects of the human system as well as in the stem cell therapeutic strategies, as in bone marrow transplantation (BMT). This book deals with several original research articles on HSC proliferation and containment. Lineage directed differentiation of HSCs and use of easily available herbal extracts for greatly increased proliferation into erythrocytes to treat thrombocytopenia are herein reported.HSCs respond to the growth factors and the herbal medicine is a welcome substitute with lack of known side effects for treatment purposes. However molecular mechanisms as in signal transduction are more easily deciphered than those derived from the herbs which may well be taken up for future studies. Mutations in the signal transduction genes such as JAK-2 have been shown to cause dysregulation of the CD34+ cell differentiation causing erythrocytosis, which is the reverse of thrombocytopenia, both of which are undesirable clinical consequences! Erythrocytes have been shown to date back to ancient tissues from the fossils.
£163.19
Nova Science Publishers Inc Beta-Galactosidase: Properties, Structure and
Book Synopsisβ-galactosidase is an enzyme responsible for catalyzing the hydrolysis of the lactose β-1,4 linkage into α-D-glucose and β-D-galactose. β-galactosidase is found in plants, animals and microorganisms. In Beta-Galactosidase: Properties, Structure and Functions, the authors discuss the main microorganisms that produce β-galactosidase, the characteristics of the culture media, bioprocessing parameters, the most relevant downstream steps used in the recovery of microbial β-galactosidase, as well as the main immobilisation techniques. Next, this compilation examines β-galactosidases classification, mechanisms, characterization and applications. Recent advances in galacto-oligosaccharides production and purification are also covered, and different challenges and future perspectives are discussed. In the closing study, strains with β-Galactosidase activity were isolated from 25 Yak Yoghourt samples collected from the Gannan pasturing area of Gansu Province. An efficient β-galactosidase producing strain SYA2 screened out from 21 strains was identified as Enterobacter sp. by means of morphological feature observation, physiological and biochemical characteristics measurement, and 16S rDNA sequence analysis.Table of ContentsFor more information, please visit our website at:https://novapublishers.com/shop/beta-galactosidase-properties-structure-and-functions/
£999.99
Nova Science Publishers Inc Lipid Bilayers: Properties, Behavior and
Book SynopsisThe book provides a broad overview of an important biological system -- 'cell membrane'. The cell is the powerhouse where processes of life are controlled. Cell membranes consist of lipid bilayers that make biological boundaries. The bilayer participates in determining most of the cell-based uptakes of materials, exchanging of information between both sides and ensuring helping vital biological processes to continue. We have focused specifically on an understanding of various aspects of lipid membrane bilayers. The book is focused on a detailed description of the diverse mechanisms and phenomena associated with membranes. Lipid bilayers exist in various parts of the cell, namely, across the plasma membrane, mitochondrial membrane, and nuclear membrane. While exploring lipid bilayers we shall, therefore, need to consider structures and functions of various sections of biological cells. Besides spectroscopic observations and electrical measurements of membrane bilayers, we address here the phenomena of coexistence and independent existence of different membrane components using various theoretical and experimental methodologies popularly used in biology, physics, mathematics, chemistry, biomedical engineering, and general medical sciences. The focus has been made on explaining diverse mechanisms that play crucial roles in molecular level in the construction of lipid bilayers and maintaining the relevant biological functions. This book will be helpful for readers who want to understand biological processes by applying both simple observations and fundamental scientific analysis. It provides a deep understanding of the causes and effects of molecular processes inside lipid bilayer membranes. A group of eminent scientists from around the globe contributed chapters focusing on different aspects. Each chapter may be found to present an individual topic and elaborate on a specific problem. But the chapters altogether have covered most of the basic aspects relevant to the title of the book. The book will be a vital reference for scientific understanding of lipid bilayers.Table of ContentsPrefaceFundamentals of Plasma, Nuclear and Mitochondrial Lipid MembranesMechanical Stresses in the Lipid Bilayer of Erythrocyte MembranesThe Role of the Lipid Bilayer in the Erythrocyte Membrane Structural ChangesMicrobial-Derived Bioactive Lipopeptides: Pore-Forming Metabolites in Lipid BilayersColchicine Induced Ion Channel Formation into Membranes as a Mechanism behind Chemotherapy Drug Cytotoxicity of Cancer CellsMolecular Stability Analysis of Reverse Micelles Role in Breast Cancer Drug Delivery and It's Dynamics and Simulation StudiesIndex.
£113.59
Nova Science Publishers Inc Membrane Potential: An Overview
Book Synopsis
£999.99
Nova Science Publishers Inc A Closer Look at Fibroblasts
Book SynopsisA Closer Look at Fibroblasts first summarizes the molecular mechanisms of fibroblasts induced by photobiomodulation, reviewing current therapeutic approaches. Photobiomodulation, previously called low intensity laser irradiation, is a safe and efficient mechanism used to stimulate a positive response through absorbed light or light emitting diodes, and to reduce pain and inflammation promoting healing of the wound area. Following this, the authors demonstrate the importance of fibroblasts in the process of development and progression of ovarian cancer, helping to establish new therapeutic management targeted towards cancer-associated fibroblasts. In the penultimate study, the effects of the combination of andiroba, copaíba and guarana in the form of biphasic oil and emulsion is examined in the context of wound healing. The concluding study focuses on the implications of the previously mentioned guarana in the context of skin aging and the oxy-inflammatory metabolism.Table of ContentsPreface; Molecular Mechanism of Photobiomodulation Associated with Fibroblasts; The Role of Fibroblasts in Ovarian Cancer; Analysis of the Effect of an Andiroba, Copaíba and Guaraná Combination on in Vitro and in Vivo Scar Models; Laser Therapy Associated With Guaraná as a Therapeutic Alternative on the Skin of Oxy-Inflammatory Metabolism; Index.
£72.24
Nova Science Publishers Inc A Closer Look at Hormones
Book SynopsisThis book provides the essential information necessary for students and scientists in the life and health sciences and chemistry of biologically active substances. The book adopts a readable, friendly style that helps introduce the reader to this fascinating and exciting world of hormones. This book is devoted to highlight the recent progress on the extraction, analysis, physico-chemical properties and the use of hormones. Much attention is paid in several chapters to steroid hormones, which play an important role in human biochemistry. Information on phytohormones and hormones in mushrooms is also original. The book presents revolutionary results in clinical trials of hormones, comparative genomic analysis, and the use of these substances as a tool for biosynthesis. The logic of the whole book is subordinated to the scheme "presence in living organisms -- identification and analysis -- properties -- application and safety" of hormones. It also includes some of the vital pieces of work being conducted across the world on various topics related to the study of biologically active substances. Through it, we attempt to further enlighten the readers about the new concepts in this field. Altogether, presented in an organized, concise, and simple-to-use format, "A Closer Look at Hormones" allows quick access to the most frequently used data.
£138.39
Nova Science Publishers Inc Leydig Cells: Structure, Functions and Clinical
Book SynopsisThe main function of the Leydig cells is to synthesize testosterone, but growing evidence supports the idea that Leydig cells are important in regulating the testicular immune environment. As such, Leydig Cells: Structure, Functions and Clinical Aspects discusses Leydig cells serving as immunological sentinels in the testis. Next, the authors explore the commercially available immortalized Leydig cell lines (TM3, R2C, MA-10 and MLTC-1) derived from rat or mouse and the results of studies using these cells. Additionally, the effects of the most commonly used environmental contaminants on Leydig cell function are discussed in the context of the impaired of steroidogenic pathway. The results of several studies are presented which demonstrate that lycopene supplementation improves and maintaines the normal level of testosterone by improving the expression of StAR protein and steroidogenic enzymes in the Leydig cells of polychlorinated biphenyl exposed rats.Table of ContentsPrefaceImmunological Function of Leydig CellsLeydig Cell Lines: In Vitro Models for Testosterone BiosynthesisThe Role of Environmental Contaminants in Leydig Cell SteroidogenesisEffect of Endocrine Disruptors (PCBs/DEHP) on Testicular Leydig Cells in Adult and f1 Male Offspring RatsBibliographyIndex.
£62.04
Nova Science Publishers Inc Cadherins: Types, Structure and Functions
Book Synopsis
£999.99
Nova Science Publishers Inc New Research on Antioxidants
Book SynopsisIn biological systems, the normal processes of oxidation (plus a minor contribution from ionising radiation) produce highly reactive free radicals. These can readily react with and damage other molecules. In some cases the body uses free radicals to destroy foreign or unwanted objects, such as in an infection. However, in the wrong place, the body''s own cells may become damaged. Should the damage occur to DNA, the result could be cancer. Antioxidants decrease the damage done to cells by reducing oxidants before they can damage the cell. Virtually all studies of mammals have concluded that a restricted calorie diet extends the lifespan of mammals by as much as 100%. This remarkable finding suggests that food is actually more damaging than smoking. As food produces free radicals (oxidants) when metabolised, antioxidant-rich diets are thought to stave off the effects of ageing significantly better than diets lacking in antioxidants. The reduced levels of free radicals, resulting from a reduction in their production by metabolism, is thought to be a major cause of the success of caloric restriction in increasing life span. Antioxidants consist of a group of vitamins including vitamin C, vitamin E, selenium and carotenoids, (such as beta-carotene, lycopene, and lutein). This book brings together the latest research in this dynamic field.
£149.99
Nova Science Publishers Inc Research Progress in Stem Cells
Book SynopsisThis book presents the latest research in the field of stem cells from around the globe. Two broad categories of mammalian stem cells exist: embryonic stem cells, derived from blastocysts, and adult stem cells, which are found in adult tissues. In a developing embryo, stem cells are able to differentiate into all of the specialised embryonic tissues. In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing specialised cells. As stem cells can be readily grown and transformed into specialised tissues such as muscles or nerves through cell culture, their use in medical therapies has been proposed. In particular, embryonic cell lines, autologous embryonic stem cells generated therapeutic cloning, and highly plastic adult stem cells from the umbilical cord blood or bone marrow are touted as promising candidates. Among the many applications of stem cell research are nervous system diseases, diabetes, heart disease, autoimmune diseases as well as Parkinson''s disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, and Alzheimer''s disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources.
£113.24
Nova Science Publishers Inc New Cell Adhesion Research
Book SynopsisCell adhesion is the binding of a cell to another cell or to a surface or matrix. This book discusses the mitochondrial retrograde signalling, a recently discovered cellular signalling pathway, that may work in irradiated mammalian cells. The question whether radiation of visible and near IR radiation can activate this cellular signalling pathway is also reviewed. Novel experimental techniques that probe cellular forces exerted at the sites of adhesive contacts are examined, as well as how these forces can explain the roles of cell adhesion in orchestrating multi-cellular behaviour. Furthermore, the cell adhesion molecule trophinin is discussed, which is uniquely involved in the process of human embryo implantation. The roles of nano and microtopography in the substratum upon cell adhesion are addressed, as well as the effects of substratum and near-substratum mechanical properties on cell adhesion. CADM1, a new mast-cell adhesion molecule that mediates interaction with fibroblasts, nerves, and smooth muscles is discussed in this book, as well as carbon nanoparticles that are used as substrates for cell adhesion and growth. In addition, by reducing cell adhesion and inducing cell proliferation, diabetes increases the risk for oral carcinogenesis. The results of this animal model study are looked as well. Finally, the epithelial cell adhesion molecule, EpCAM, has been studied and subsequently discussed in this book.
£999.99
Nova Science Publishers Inc Glycolysis: Regulation, Processes & Diseases
Book SynopsisGlycolysis literally means "splitting sugars". In glycolysis, glucose (a six carbon sugar) is split into two molecules of a three-carbon sugar. Glycolysis yields two molecules of ATP (free energy containing molecule), two molecules of pyruvic acid and two "high energy" electron carrying molecules of NADH. Glycolysis can occur with or without oxygen. In the presence of oxygen, glycolysis is the first stage of cellular respiration. Without oxygen, glycolysis allows cells to make small amounts of ATP. This process is called fermentation. This book presents the latest research in the field.
£129.74
Nova Science Publishers Inc Handbook of Cell Proliferation
Book SynopsisCell proliferation is an increase in the number of cells as a result of cell growth and cell division. A series of growth disorders can occur at the cellular level, often causing cancer. This book examines and discusses recent developments in this field. In particular, the changes that occur in cell viability, cell proliferation and cytotoxicity following therapy and laser irradiation are studied. Furthermore, the effects that probiotic bacteria and gastrointestinal mucosa have on cell proliferation are looked at. Data from literature suggests a possible use for probiotics in the therapeutic management of different diseases. This book reviews the ways to estimate cell proliferation and a general view about the principal methods used to evaluate cell populations kinetics are given. Also, research has shown that reductions in cell proliferation by nutrition interventions may indicate a decrease in cancer risk. Thus, this book examines the ability of dietary restriction regiments to reduce cell proliferation rates and cancer risks in humans and animals.
£182.99
Nova Science Publishers Inc Cell Determination During Hematopoiesis
Book SynopsisFor many years the mammalian blood cell system has provided cell biologists and haematologists with one of the best experimental models in which to unravel how one stem cell -- the hematopoietic stem cell -- gives rise to many different types of progeny. Numerous models of lineage relationships have emerged, but the most influential of these, in which differentiating cells undergo a series of binary choices, has been increasingly challenged in recent years -- to the extent that the accumulation of new findings recently culminated in a Nature commentary suggesting that "the latest research will necessitate revision of textbook accounts". This book brings together contributions from many leading experts in the field of blood cell development who each discuss both the overall process of hematopoiesis and the origins and development of each of the cells of the blood and immune systems. It describes how new molecular, cellular and -- particularly -- transgenic tools are helping us understand the processes that control the lineage fates of hematopoietic stem and progenitor cells and how lineage-committed progeny develop along particular maturation pathways.
£86.99
Nova Science Publishers Inc Basophil Granulocytes
Book SynopsisThis book examines the latest research developments in the field of basophil granulocytes, sometimes referred to as basophils, which are the least common of the granulocytes, representing about 0.01% to 0.3% of circulating white blood cells. The name comes from the fact that these leucocytes are basophilic, i.e., they are susceptible to staining by base dyes, as shown in the picture. Basophils contain large cytoplasmic granules which obscure the cell nucleus under the microscope. However, when unstained, the nucleus is visible and it usually has 2 lobes. The mast cell, a cell in tissues, has many similar characteristics.
£86.99
Nova Science Publishers Inc Handbook of Free Radicals: Formation, Types &
Book SynopsisFree radicals are molecules, ions, or atoms with unpaired electrons in their outermost shell of electrons. Although it is a relatively recent discovery, the occurrence of free radicals in biological processes is now widely accepted. Free radicals are involved in the pathogenesis of many diseases, such as diabetes, cardiovascular and pulmonary diseases and also in inflammation. Free radicals are also involved in important physiological processes, such as ageing. Free radicals are constantly formed in the human body, but they can become toxic when generated in excess or in the presence of a deficiency in the naturally occurring antioxidant defences. In general, the body has adequate antioxidant defences to cope with the production of free radicals under physiological conditions. This book reviews the updated knowledge on free radicals and its possible mechanisms in neurological disorders and in some oxidative stress processes, such as in intractable epilepsy and febrile seizures. Some approaches useful to elucidate the effects of free radical exposure on the overall protein structure are also discussed. Additionally, the potential risk factors and major cellular events contributing to the generation of reactive oxygen species and retinal pigment epithelium (EPI)/photoreceptor cell damage, and their roles in the pathogenesis of AMD are examined. Furthermore, thyroid cells are a unique model to study free radical processes involving reactive oxygen and iodine species. The role of oxidative stress in impairment in the thyroid function is explored. Other chapters in this book explore free radicals and its role in the in vivo disease control of malaria, as well as the monitoring of free radical in ultrasonic field in vitro and in vivo, its role in laboratory medicine, the relationship between rabies and free radicals, the correlation between exercise and free radical production, and the role of free radicals in several homeostatic processes through methods that can be used to detect free radicals either directly or indirectly (also known as fingerprinting methods).
£262.49
Nova Science Publishers Inc Handbook of Molecular Chaperones: Roles,
Book SynopsisMolecular chaperones are a ubiquitous class of proteins that play important roles in protein folding and in the protection of cells from several stresses associated with the disruption of three native dimensional structures of proteins. The most important of these proteins are the so-called heat shock proteins (HSPs), also known as stress proteins. This book examines some of the biological aspects of this intriguing family of proteins that are important for consideration of the "proteiomics of HSPs". This book also reviews current research on protein folding in the endoplasmic reticulum (ER) and the functions of ER-resident molecular chaperones in protein folding in the ER. The biochemical, structural and functional information on Redox Enzyme Maturation Proteins (REMPs) are also reviewed in detail. Furthermore, recent progress in molecular biology has provided new insights into the molecular basis of diseases and molecular targets for diagnosis and therapy of human diseases. The role of molecular biology research in molecular imaging is examined, as well as the applications of molecular imaging in diagnostics, gene therapy and drug development. Other chapters in this book explore the role of protists as promising objects for the study of adaptive mechanisms at the biochemical and the molecular level, the different trends in the evolution of molecular adaptations to adverse environmental conditions, and a review of the molecular mechanisms of bicyclol in the protection against liver damage.
£262.49
Nova Science Publishers Inc Cell Respiration & Cell Survival: Processes,
Book SynopsisIn this book, the current understanding of the mechanisms of each beta cell toxins are reviewed, reported toxin resistant insulinoma or immortalised beta cells are summarised, and the different nature of those toxin resistant cells are analysed. With advancements in cancer stem cell research, the possible involvement of stem cells enrichment after various toxin challenges is also discussed. Moreover, there is a renewed interest in the study of the function of fatty acid synthase (FASN) and fatty-acid synthesis in cancer pathogenesis. This book outlines the role of FASN in cancer development and the pre-clinical development of FASN inhibitors and their anti-tumour effects. In addition, Parkinson disease (PD) is a neurodegenerative disorder characterised by a progressive loss of the nigrostriatal dopaminergic neurons. The authors discuss the roles of oxidative modification of the proteins of mitochondrial respiration in the pathogenesis of PD. Furthermore, it has been currently understood that the key role in the physiological and regenerative restoration of adult tissues belongs to adult stems cells. Adult stem cell survival after the action ionizing radiation, hyperthermia and in the conditions of the "ischemia/reperfusion" reaction development are examined.
£185.99
Nova Science Publishers Inc Daughter Cells: Properties, Characteristics &
Book SynopsisThis book summarises some of the major processes involved in the production of daughter cells as they have been reported from work mainly with synchronous cultures of microalgae over the 50 years or so since that technique was first developed. It highlights the key findings that have led to our present understanding of cell cycle processes in microalgae with particular reference to those that control daughter-cell production. The authors of this book also systematise the data on molecular genetic system controlling drosophila bristle morphogenesis and proposes an integral scheme of its functioning. In addition, the current understanding of kidney regeneration after injury are examined from the perspective of renotropic factors, renal stem/progenitor cells, and stem cell therapies. In unicellular and multicellular organisms, asymmetric division enables segregation of damaged molecules into one daughter cell. The authors suggest that partition of damaged proteins and organelles and segregation of template DNA may function together to produce long-lived stem cells. Daughter cells'' behavior of the chlorarachniophytes are also described and the evolution and biological implications are discussed. Lastly, recent advances in stem cell biology are summarised, and ways in which clinical medicine could take advantage of this fascinating field of biology are examined.
£155.99
Nova Science Publishers Inc Cell Division: Theory, Variants & Degradation
Book SynopsisCell division is a highly co-ordinated process by which the living organisms grow, develop and reproduce. This book presents original research results on the leading edge of cell division research. Each article has been carefully selected in an attempt to present substantial research results across a broad spectrum.
£116.24
Nova Science Publishers Inc Golgi Apparatus: Structure, Functions &
Book SynopsisThe Golgi apparatus is an organelle found in most eukaryotic cells. The primary function of the Golgi apparatus is to process and package macromolecules, such as proteins and lipids, after their synthesis and before they make their way to their destination. This book presents topical research data in the study of Golgi apparatus, including Golgi organisation and stress sensing; signalling pathways controlling mitotic Golgi breakdown in mammalian cells; the role of Golgi apparatus in the biological mechanisms of hypericin-mediated photodynamic therapy; the role of the Trans-Golgi Network (TGN) in the sorting of nonenzymic lysosomal proteins; and the mechanisms involving the role of Golgi apparatus alteration in neurological disorders triggered by manganese.
£999.99
Nova Science Publishers Inc Leptin: Hormonal Functions, Dysfunctions &
Book SynopsisThis book presents topical research in the study of leptin, including the interaction of leptin with stress system components; the effects of serum leptin levels of some drugs; leptin as a novel therapeutic reagent in the fight against neurodegenerative diseases; the role of leptin in the activation of the immune system; gender difference in leptin production and leptin senstitivity and neonatal leptin surge.
£166.49
Nova Science Publishers Inc CACO-2 Cells & their Uses
Book SynopsisCACO-2 cell cultures are widely used in vitro models in several scientific fields such as nutrition, physiopathology, pharmacology, and toxicology. When cultured onto filters, these cells form a highly polarised epithelium that allows discrimination between apical and basolateral compartments. This book presents topical research in the study of CACO-2 cells and their uses. Topics discussed include the application of CACO-2 cell models as a supportive in vitro tool during drug discovery and formulation; co-culture systems with CACO-2 cells to evaluate the bioactivity of plant extracts and the use of CACO-2 cells in intestinal transport, cell-matrix interactions and wound healing in intestinal villus cells.
£86.99
Nova Science Publishers Inc Encyclopedia of Cell Biology Research
Book SynopsisThis book presents and discusses current research in the study of cell biology. Topics discussed include a new mast-cell adhesion molecule; carbon nanoparticles as substrates for cell adhesion; stress and pancreatic ß cell function; beta cell glucotoxicity; toxin resistant beta-cells; cell division and cell elongation of corynebacterium glutamicum; cell cycle checkpoints and cancer and cyanobacterial cell division.
£278.99
Nova Science Publishers Inc Potassium Channels: Types, Structure & Blockers
Book Synopsis
£106.49
Nova Science Publishers Inc Endocytosis: Structural Components, Functions &
Book SynopsisEndocytosis is the process by which cells absorb molecules (such as proteins) from outside the cell by engulfing it with their cell membrane. It is used by all cells of the body because most substances important to them are large polar molecules that cannot pass through the hydrophobic plasma membrane or cell membrane. Endocytosis is required for a vast number of functions that are essential for the well being of a cell. It intimately regulates many processes, including nutrient uptake, cell adhesion and migration, receptor signalling pathogen entry, neurotransmission, receptor down-regulation, antigen presentation, cell polarity, mitosis, growth and differentiation, and drug delivery. This book examines the functions and benefits of endocytosis in regards to cells within the body.
£999.99
Nova Science Publishers Inc Dendritic Cells: Types, Life Cycles & Biological
Book SynopsisDendritic cells (DCs) are professional antigen presenting cells (APCs) that were discovered several decades ago. They play a crucial role in the innate and adaptive immune response against bacteria or viruses. This book reviews research in the field of dendritic cells including a review of the recent progress in understanding the correlation between the approach used to obtain dendritic cells and their related properties, in order to indicate a correct application of DCs for research or clinical studies.
£176.24
Nova Science Publishers Inc Chemotaxis: Types, Clinical Significance, &
Book SynopsisChemotaxis is the phenomenon in which bodily cells, bacteria, and other single-cell or multicellular organisms direct their movements according to certain chemicals in their environment. This is important for bacteria to find food by swimming towards the highest concentration of food molecules, or to flee from poisons. In multicellular organisms, chemotaxis is critical to early and subsequent phases of development, as well as in normal function. This book discusses research in the study of chemotaxis including the cell migration signalosome, the role of chemotaxis in the association of the azospirillum brasilense plant, the role of CD46 in the control of chemotaxis of activated T cells in MS pathogenesis and the regulation of chemotaxis by heterotrimeric G proteins.
£86.99
Nova Science Publishers Inc Stem Cells & Regenerative Medicine: Volume VI -
Book SynopsisStem cells are the building blocks of the body. They can develop into any of the cells that make up our bodies. Stem cells carry a lot of hope for the treatment of a broad range of diseases and injuries, spanning from cancers, diabetes, genetic diseases, graft-versus-host disease, eye, heart and liver diseases, inflammatory and autoimmune disorders, to neurological diseases and injuries, particularly neurodegenerative diseases, like Alzheimer''s and Parkinson''s diseases, cerebral strokes, and traumatic brain and spinal cord injuries. Stem cell research is therefore as important for understanding the Physio- and pathology of the body as for development and therapy as well as for understanding the nervous system. This book provides an overview and in depth analysis of recent developments in stem cell research and therapy.
£162.74
Nova Science Publishers Inc Stem Cell, Regenerative Medicine & Cancer
Book SynopsisOf the estimated trillion cells that build up our bodies, only a little number can self-renew and give rise to many different cell types. These unspecialised cells are called stem cells. Stem cell division and differentiation is fundamental to the development of the mature organism. Stem cells have recently attracted significant attention largely due to their potential medical benefits in the fields of therapeutic cloning and regenerative medicine. Because stem cells can become many specialised types of cells of the organs, they have the potential to treat many diseases, including Alzheimer''s disease, Parkinson''s disease, type-1 diabetes, spinal cord injury, stroke, burns, heart disease, osteoarthritis, and rheumatoid arthritis. This book focuses on the application of stem cells in regeneration and repair of the organs in disease and ageing.
£189.74
Nova Science Publishers Inc Beta Cells: Functions, Pathology & Research
Book SynopsisBeta cells or ß-cells, are a type of cell in the pancreas in areas called the islets of Langerhans. They make up 65-80% of the cells in the islets. Pancreatic B-cell is the only cell type that produces insulin to regulate glucose metabolism in the body. The insufficiency of insulin-producing B-cells results in dysregulation of blood glucose control, termed as type 1 diabetes. This book presents current research from across the globe in the study of Beta-cells, including the induction of pancreatic cancer cell death by elevated concentrations of extracellular zinc; the role of Rab GTPases and their effectors in the insulin secretory pathway of the pancreatic beta cell; In vivo reprogramming of pancreatic A-cells into B-like cells; and the role of glucocortoids, exercise and glucolipotoxicity with regard to stress and pancreatic B-cell function.
£999.99
Nova Science Publishers Inc Microglia: Biology, Functions & Roles in Disease
Book Synopsis
£185.99
Nova Science Publishers Inc Autophagy: Principles, Regulation & Roles in
Book SynopsisThis book gives an up-to-date overview of the biomedical aspects of autophagy research, a large interdisciplinary field emerging on intersection of (i) cell, developmental, and cancer biology, (ii) tissue remodelling and plasticity, ageing and longevity; (iii) immunology, microbiology, toxicology, and pathobiology; (iv) regenerative and adaptive biomedicine; and (v) pharmacology.
£192.74
Nova Science Publishers Inc Dysplasia: Causes, Types & Treatment Options
Book SynopsisIn this book, the authors present topical research in the study of the causes, types and treatment options for dysplasia. Topics discussed include colonic polyps and hereditary polyposis syndromes; developmental hip dysplasia; the causes and treatment options for bone dysplasia; a discussion on whether elevated intracellular chloride causes epilepsy in cortical dysplasia and dysplasia in ulcerative colitis.
£106.49
Nova Science Publishers Inc Eosinophils: Structure, Biological Properties &
Book SynopsisThe eosinophil is an enigmatic cell with a continuing ability to fascinate. In this book, experts in the field of eosinophil biology comprehensively update our knowledge on the human eosinophil in health and disease. Topics discussed include a synopsis of eosinophil characteristics, properties and role in disease. Important information on how eosinophils release their potent and toxic granule proteins will be covered and how these basic proteins give rise to pathologies including issues such as the function of the nerves.
£152.99
Nova Science Publishers Inc Granulocytes: Production, Types & Roles in
Book SynopsisThis book examines the latest research developments in the study of the production, types and roles in disease of granulocytes. Topics include the regulation of granulocyte differentiation by microRNA and transcription factors; chemotactic assay of human neutrophils and eosinophils; basophilic granulocytes; and the role of granulocytes on the onset of tissue-destructive diseases.
£67.99
Nova Science Publishers Inc Leukocytes: Biology, Classification & Role in
Book SynopsisWhite blood cells, or leukocytes are cells of the immune system involved in defending the body against both infectious disease and foreign materials. Five different and diverse types of leukocytes exist, but they are all produced and derived from a multipotent cell in the bone marrow known as a hematopoietic stem cell. They live for about 3 to 4 days in the average human body. In this book, the authors present current research in the study of the biology, classification and role in disease of leukocytes. Topics include an analysis of peptides and proteins isolated from alligator leukocytes; modification of immune cell activity by neuroendocrine mediators and development of disease; congenital defects of phagocytes; leukocyte mitochondrial membrane potential in type 1 diabetes; biology of human myeloid dendritic cells; and the leukocyte expression of CD36 as a biomarker for Alzheimer''s disease.
£149.99
Nova Science Publishers Inc Bilirubin: Chemistry, Regulation & Disorder
Book Synopsis
£146.24
Nova Science Publishers Inc Proline: Biosynthesis, Regulation & Health
Book SynopsisProline might be the most studied amino acid in nature. Many authors have reviewed its many functions in cell homoeostasis. Not only it is essential in primary metabolism, but it is also involved in cell defence response to a variety of stresses. This book presents topical research data in the study of pro-line functions, including role of pro-line in plant subject to salinity, pro-line cycle and its role in secondary metabolite accumulation, role of pro-line in catalysing the asymmetric reaction, studies of polyproline peptides, structural characteristics and transition mechanisms of proline-rich peptides, functions of proline in behaviour of neonatal chicks and tumour suppressor activities of proline oxidase.
£119.99
Nova Science Publishers Inc Antimicrobial Peptides: Properties, Functions &
Book SynopsisAntimicrobial peptides (AMPs) are small peptides which exhibit broad-spectrum antimicrobial activity and often activity against virus. In addition, AMPs exert several functions including endotoxin neutralization, chemotactic and immunomodulating activities, angiogenesis, and wound repair. In this book, the authors discuss the innate immune system and lipopolysaccharides; the biological role of fish antimicrobial peptides; casein-derived peptides; antimicrobial peptides in intestinal inflammation and infection; insect antimicrobial peptides in immunity and mechanisms of action; potential of AMPs as therapeutic tools against infectious disease; and how LC-MS/MS-based quantitative protein profiling can aid mechanistic studies of antimicrobial peptides.
£159.74
Nova Science Publishers Inc Cell Proliferation: Processes, Regulation &
Book SynopsisCellular proliferation, as a result of cell growth and cell division, is one of the most fundamental biological processes. Although there is a great deal which remains unclear, significant advances have been made in past decades in our understanding of the process and regulation of cell proliferation. There is considerable evidence that this understanding of different cells and cell proliferation behaviour provides useful information that may be of major importance in disease control, drug discovery, biomaterial development and medical device improvement. This book studies and discusses recent developments in the field of cell proliferation including: the controlling factors for cell proliferation; changes occurring in the cells; therapeutic effects of the biological molecules to the cells; and analysis of cell proliferation based on the quantal concept. Furthermore, the effects that biomaterials and drugs have on cell proliferation are also reviewed in this book.
£159.74
Nova Science Publishers Inc Osteoblasts: Morphology, Functions & Clinical
Book SynopsisOsteoblasts are highly specialised mesenchymal cells that are mainly responsible for the formation and maintenance of the skeletal architecture. They produce extracellular matrix proteins and are regulators of matrix mineralisation during bone formation and remodelling. In this book, the authors discuss the morphology, functions and clinical implications of osteoblasts. Topics include osteoblasts under mechanical strain; mesenchymal stem cells (MSC) into osteoblasts for bone tissue engineering; osteoblast function and their role in skeletal bone diseases; bone morphogenetic proteins (BMP) and osteoblastogenesis inhibitors; the effect of molecular and biochemical differentiation agents on bone formation; and the evaluation of characteristics of osteoblasts and factors related to osteoblastic differentiation and mineralisation.
£159.74
Nova Science Publishers Inc Angiogenesis: Insights from a Systematic Overview
Book SynopsisThis book provides an overview of the scientific methods used to search, analyse, appraise and synthesise studies on angiogenesis. It is intended to serve as a comprehensive piece of literature that encompasses all aspects from the molecular features of angiogenesis to the clinical value and potential pitfalls of angiogenic-based therapies. The primary motion to write this book is to provide an overview of the current status of the research in this field, with a focus on both tumoural and non-tumoural disease. Effects of various anti-angiogenic and pro-angiogenic molecules are also addressed in detail. This book comes at an important time in the development of so-called "translational medicine". Its purpose is to explain all the molecular bases underlying the angiogenic process and apply them to the clinical world. Reviewed and addressed are the basic concepts and importance of new drugs in clinical trials to inhibit or promote angiogenesis. This book may be considered as a scholarly reference work for libraries and researchers across the world and as a supplementary text for courses in medicine, physiology, biochemistry, molecular and cellular biology. It is expected that readers, both basic researchers and clinicians, will gain a good understanding of the essential value of angiogenesis in health and disease.
£159.74
Nova Science Publishers Inc Keratinocytes: Structure, Molecular Mechanisms &
Book SynopsisThe human skin is constantly exposed to a large number of external pathogens, due to daily contact with the environment. The observation that extensive skin infections are relatively rare suggests the presence of an efficient host defence system at the skin surface. Recent findings indicate the importance of keratinocytes as effectors of innate immunity, but also as regulators of acquired immune responses, inflammation and wound repair. This book considers the current findings regarding the role of keratinocytes in the epidermis with special interest to mechanisms involved in host defence. Finally, the clinical relevance of the functions of keratinocytes in the innate immunity is also discussed.
£106.49
Nova Science Publishers Inc Cell Membrane: Molecular Structure,
Book SynopsisIn this book, the authors present current research in the study of the molecular structure, physiochemical properties and interactions with the environment of cell membranes. Topics discussed in this compilation include the generation and characterisation of recombinant HM-1 single-chain anti-idiotypic antibodies and their applications; large conductance of calcium activated potassium channels from protein complexes to function in mitochondrial associated ER membranes; unexpected plasma membrane location for a disulphide isomerase protein; and the effects of surface charge and particle size of cell-penetrating peptide/nanoparticle complexes on cellular internalisation.
£73.49
Nova Science Publishers Inc Stellate Cell (Vitamin A-Storing Cell) System
Book SynopsisPast, present, and future research of hepatic stellate cells (HSCs; also called vitamin A-storing cells, lipocytes, interstitial cells, fat-storing cells, Ito cells) are summarised and discussed in this review. Kupffer discovered black-stained cells in the liver by the gold chloride method and named the cells the stellate cells (Sternzellen in German) in 1876. Wake re-discovered the cells in 1971 using the same gold chloride method and various modern histological techniques including electron microscopy. Between the discovery and re-discovery, the HSCs disappeared from the history of research. Identification, establishment of cell isolation and culture methods, and the development of cellular and molecular biological techniques have promoted HSC research after the re-discovery of the cell. The research is entering a new era, namely, the golden age after the dark ages. In the future, the research of HSCs will develop more into not only the clinical field but also into the basic research fields. In this book, we describe the past, present, and future of HSC research.
£146.24
Nova Science Publishers Inc B Cells: Molecular Biology, Developmental Origin
Book SynopsisB cells belong to a group of white blood cells known as lymphocytes, making them a vital part of the immune system. The human body makes millions of different types of B cells each day that circulate in the blood and lymphatic system performing the role of immune surveillance. They do not produce antibodies until they become fully activated. In this book, the authors present current research in the study of the molecular biology, developmental origin and impact on the immune system of B cells. Topics discussed include the role of B cells in intracellular bacterial pathogen infections; dynamic clustering of BCR-lipid rafts in antigen affinity discrimination by B cells; and B cells as a key player in the pathogenesis of multiple sclerosis.
£73.49
Nova Science Publishers Inc Progenitor Cells: Biology, Characterization &
Book SynopsisIn this book, the authors present current research in the study of the biology, characterisation and potential clinical application of progenitor cells. Topics discussed include endothelial progenitor cells and cardiovascular disease; isolation, expansion and clinical therapy of human corneal epithelial stem/progenitor cells; genetically engineered blood pharming; regulation of neural progenitor cells by Wnt5a-signaling in the developmental central nervous system; endothelial progenitor cells in a clinical setting; role of microRNAs in endothelial progenitor cells and their implication for cardiac repair; and cellular origins in amphibian regeneration.
£106.49
