Description

Book Synopsis
The main function of the Leydig cells is to synthesize testosterone, but growing evidence supports the idea that Leydig cells are important in regulating the testicular immune environment. As such, Leydig Cells: Structure, Functions and Clinical Aspects discusses Leydig cells serving as immunological sentinels in the testis. Next, the authors explore the commercially available immortalized Leydig cell lines (TM3, R2C, MA-10 and MLTC-1) derived from rat or mouse and the results of studies using these cells. Additionally, the effects of the most commonly used environmental contaminants on Leydig cell function are discussed in the context of the impaired of steroidogenic pathway. The results of several studies are presented which demonstrate that lycopene supplementation improves and maintaines the normal level of testosterone by improving the expression of StAR protein and steroidogenic enzymes in the Leydig cells of polychlorinated biphenyl exposed rats.

Table of Contents
PrefaceImmunological Function of Leydig CellsLeydig Cell Lines: In Vitro Models for Testosterone BiosynthesisThe Role of Environmental Contaminants in Leydig Cell SteroidogenesisEffect of Endocrine Disruptors (PCBs/DEHP) on Testicular Leydig Cells in Adult and f1 Male Offspring RatsBibliographyIndex.

Leydig Cells: Structure, Functions and Clinical

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    A Paperback / softback by Bruno Solomon

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      Book details

      Publisher Nova Science Publishers Inc
      Published 1 April 2020
      ISBN-13 9781536172829
      978-1536172829
      ISBN-10 1536172820
      Also in:
      Cellular biology (cytology)

      Description

      Book Synopsis
      The main function of the Leydig cells is to synthesize testosterone, but growing evidence supports the idea that Leydig cells are important in regulating the testicular immune environment. As such, Leydig Cells: Structure, Functions and Clinical Aspects discusses Leydig cells serving as immunological sentinels in the testis. Next, the authors explore the commercially available immortalized Leydig cell lines (TM3, R2C, MA-10 and MLTC-1) derived from rat or mouse and the results of studies using these cells. Additionally, the effects of the most commonly used environmental contaminants on Leydig cell function are discussed in the context of the impaired of steroidogenic pathway. The results of several studies are presented which demonstrate that lycopene supplementation improves and maintaines the normal level of testosterone by improving the expression of StAR protein and steroidogenic enzymes in the Leydig cells of polychlorinated biphenyl exposed rats.

      Table of Contents
      PrefaceImmunological Function of Leydig CellsLeydig Cell Lines: In Vitro Models for Testosterone BiosynthesisThe Role of Environmental Contaminants in Leydig Cell SteroidogenesisEffect of Endocrine Disruptors (PCBs/DEHP) on Testicular Leydig Cells in Adult and f1 Male Offspring RatsBibliographyIndex.

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