Cellular biology (cytology) Books

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Book SynopsisWhy do the best-known examples of evolutionary change involve the alteration of one kind of animal into another very similar one, like the evolution of a bigger beak in a bird? Wouldn''t it be much more interesting to understand how beaks originated? Most people would agree, but until recently we didn''t know much about such origins. That is now changing, with the growth of the interdisciplinary field evo-devo, which deals with the relationship between how embryos develop in the short term and how they (and the adults they grow into) evolve in the long term. One of the key questions is: can the origins of structures such as beaks, eyes, and shells be explained within a Darwinian framework? The answer seems to be yes, but only by expanding that framework. This book discusses the required expansion, and the current state of play regarding our understanding of evolutionary and developmental origins.Trade Review'Wallace Arthur treats his readers to an eminently readable but still deeply rooted introduction into one of the most significant achievements of evolutionary biology: how evolutionary developmental biology put the organism back into the centre of evolutionary thinking.' Günter P. Wagner, Yale University, USA'Evo-devo deals with the multiple connections that exist between the biological processes of evolution and development. However, as an interface subject, there is a plurality of views on its content and its boundaries. In spite of that, Wallace Arthur has succeeded in writing an extremely clear and highly accessible guide to this fascinating, multifaceted discipline. Using the concept of 'developmental repatterning' as a common thread, the book provides a balanced view of evo-devo, covering its main achievements and future challenges. This is an ideal entry point for the non-specialist, but also a stimulating read for the practitioner who wants to consider her/his research in a wider perspective.' Giuseppe Fusco, University of Padova, Italy'Occasionally I feel that the field of Evolution and Development has lost its way, becoming submerged in myriad examples and details that don't expand our understanding of life. Wallace's book expounds the intellectual underpinnings of Evolution and Development, leads us through the key questions, and finally shows how the details and examples inform our future understanding. This book provides not just a guide to Evolution and Development, but also a spur to refocus and redouble our efforts to use development to help understand the evolution of life on Earth.' Peter Dearden, University of Otago, New ZealandTable of ContentsPreface; Acknowledgements; 1. What is evo-devo and why is it important?; 2. Antecedents of evo-devo; 3. Evolutionary and developmental essentials; 4. Evo-devo essentials; 5. The evolution of variations on a theme; 6. The evolutionary origins of themes and novelties; 7. The evolutionary origins of body plans; 8. Body plan features and toolkit genes; 9. Bringing it all together; Concluding remarks; Summary of common misunderstandings; References; Index.

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Book Synopsis'One of my favourite science writers' Bill Gates 'Hugely important' Jim Al-Khalili 'A profound meditation on metabolism, the Krebs cycle & the origin of life' Anil Seth For decades, biology has been dominated by information - the power of genes. Yet there is no difference in information content between a living cell and one that died a moment ago. A better question goes back to the formative years of biology: what processes animate cells and set them apart from lifeless matter? In Transformer, Nick Lane turns the standard view upside down, capturing an extraordinary scientific renaissance that is hiding in plain sight. At its core is an amazing cycle of reactions that uses energy to transform inorganic molecules into the building blocks of life - and the reverse. To understand this cycle is to fathom the deep coherence of the living world. It connects the origin of life with the devastation of cancer, the first photosynthetic bacteria with our own mitochondria, sulphurous sludges with the emergence of consciousness, and the trivial differences between ourselves with the large-scale history of our planet.Trade ReviewA stone-cold classic -- Adam RutherfordOne of the most creative of today's biologists ... this is a book filled with big ideas, many of which are bold instances of lateral thinking * New Scientist *Bold ... passionate ... a dramatically revisionist account [of the] origins of life * New Yorker *A thrilling tour of the remarkable stories behind the discoveries of some of life's key metabolic pathways and mechanisms. He lays bare the human side of science ... The book brings to life the chemistry that brings us to life ... masterful * Science *Deeply researched and cogently written * Nature *Remarkable * New Humanist *Transformer is a complex yet accessible, illuminating, and thrilling exploration of the vitality and elemental mysteries of our existence * Booklist *Biochemist Nick Lane is one of our boldest thinkers and a key researcher into the origin and deep history of life. -- Peter Forbes * Prospect *Nick Lane challenges us to see life differently ... probably the best book on biology I've ever read -- Brian Clegg * Popular Science *A thrilling journey... the book is a tour de force. -- Laura Eme and Courtney W. Stairs * Nature Ecology & Evolution *In this compulsively readable book, Lane takes us on a riveting journey, ranging from the flow of energy to new ways of understanding cancer. Lane provides a luminous understanding of how scientists, including Lane himself, are rethinking energy and living organisms. -- Siddhartha Mukherjee, author * The Emperor of All Maladies, The Gene: An Intimate History *Nick Lane's exploration of the building blocks that underlie life's big fundamental questions - the origin of life itself, aging, and disease - have shaped my thinking since I first came across his work. He is one of my favourite science writers -- Bill GatesHugely important ... a powerfully persuasive case for life being about energy flow, flux and change. In Transformer, chemistry is quite literally brought to life -- Jim Al-Khalili, author * The World According To Physics *Amazing! Takes science writing to a new level ... with soaring prose but uncompromising on scientific detail, Transformer made me think about life on earth in a completely different way. -- Daniel M. Davis, author * The Secret Body *Hugely ambitious and tremendously exciting ... Transformer shows how a molecular dance from the dawn of time still sculpts our lives today. I read with rapt attention. -- Olivia Judson, evolutionary biologist and authorA thrilling and highly persuasive account of what makes life and how the miracle started, coaxed not by genes but a remarkable cycle of energy and matter - a chemical cycle able to conjure the material of life from the elements of a rocky blue planet. This hugely important book is set to become a landmark, transforming our understanding of how life works. Lane's infectious enthusiasm had me gripped on a tour down the aeons and deep into the inner workings of our cells, to discover the chemistry that gives me the sentience for such fundamental self-knowledge. Marvellous -- Gaia Vince, author * Nomad Century, Adventures in the Anthropocene *Nobody explains the inner secrets of the living cell better than Nick Lane. He clarifies the complexities of the chemistry that drives all life in a most engaging way. The stories of how this hidden world was revealed by remarkable scientists is explored as a series of riveting detective stories, leaving the reader with admiration for the ingenuity and sheer persistence of those who unscrambled the reactions that underlie all life. -- Richard Fortey FRS FRSL, author * Fossils: The Key to the Past *An exhilarating account of the biophysics of life, stretching from the first stirrings of living matter to the psychology of consciousness. I felt as if I was there, every step of the way -- Mark Solms, author * The Hidden Spring: A Journey to the Source of Consciousness *Nick Lane never writes about the living world without offering entirely new perspectives on how life itself works. Transformer is no exception. His subject here - the Krebs cycle - is often seen as one of the driest staples of biochemical textbooks. But in Lane's hands, it becomes a key to life's origins and driving forces, to health, disease and ageing, and even to our awareness of the world. Biochemistry has never looked more exciting. -- Phillip BallNick Lane's marvellously engaging Transformer refocused my astronomer's gaze on the vital chemistry of life on our own planet. Both a scientific adventure story and an original quest to understand life on Earth, Transformer also guides us on how to find life beyond -- John Grunsfeld, former NASA Chief Scientist and AstronautA profound meditation on metabolism, the Krebs cycle & the origin of life. -- Anil Seth, author * Being You: A New Science of Consciousness *

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Book SynopsisIn just a half century, humanity has made an astounding leap in its understanding of life. Now, one of the giants of biological science, Christian de Duve, discusses what we''ve learned in this half century, ranging from the tiniest cells to the future of our species and of life itself. With wide-ranging erudition, de Duve takes us on a dazzling tour of the biological world, beginning with the invisible workings of the cell, the area in which he won his Nobel Prize. He describes how the first cells may have arisen and suggests that they may have been like the organisms that exist today near deep-sea hydrothermal vents. Contrary to many other scientists, he argues that life was bound to arise and that it probably only took millennia--maybe tens of thousands of years--to move from rough building blocks to the first organisms possessing the basic properties of life. With equal authority, De Duve examines topics such as the evolution of humans, the origins of consciousness, the developmentTrade Review"A well-written, engaging scientific tour de force.... de Duve exhibits an extraordinary skill in conveying his deep knowledge of biology.... Both a first-rate scholar and an accomplished popularizer of science...de Duve moves with equal familiarity and eloquence from scientific papers to French poets.... Life Evolving forces the reader to avoid intellectual complacency and to articulate one's own arguments to effectively address his position. These are, in themselves, major reasons to appreciate the book."--Science "This book is addressed to the educated lay person interested in the origin of life, its evolution to the present day and its philosophical implications. The reader is in for a treat of unsurpassed lucid and poetic writing. It is the testament of one of the great biologist-philosophers of our time."--Gunter Blobel, Nobel Laureate in Physiology and Medicine "An original thinker and graceful writer, Christian de Duve is an E.O. Wilson for the cell. In Life Evolving, De Duve lays bare the molecular machinery of life, finding both explanation of our evolutionary past and signs of what it will mean to be human in the twenty-first century."--Andrew H. Knoll, Fisher Professor of Natural History, Harvard University "A well-written, engaging scientific tour de force.... de Duve exhibits an extraordinary skill in conveying his deep knowledge of biology.... Both a first-rate scholar and an accomplished popularizer of science...de Duve moves with equal familiarity and eloquence from scientific papers to French poets.... Life Evolving forces the reader to avoid intellectual complacency and to articulate one's own arguments to effectively address his position. These are, in themselves, major reasons to appreciate the book."--Science "This book is addressed to the educated lay person interested in the origin of life, its evolution to the present day and its philosophical implications. The reader is in for a treat of unsurpassed lucid and poetic writing. It is the testament of one of the great biologist-philosophers of our time."--Gunter Blobel, Nobel Laureate in Physiology and Medicine "An original thinker and graceful writer, Christian de Duve is an E.O. Wilson for the cell. In Life Evolving, De Duve lays bare the molecular machinery of life, finding both explanation of our evolutionary past and signs of what it will mean to be human in the twenty-first century."--Andrew H. Knoll, Fisher Professor of Natural History, Harvard UniversityTable of ContentsIntroduction ; 1. What is Life? (a: Chemistry) ; 2. What is Life? (b: Information) ; 3. Where Does Life Come From? ; 4. How Did Life Arise? (a: The Way to RNA) ; 5. How Did Life Arise? (b: From RNA to Protein-DNA) ; 6. How Did Life Arise? (c: The Birth of Cells) ; 7. The History of Life ; 8. The Invisible World of Bacteria ; 9. The Mysterious Birth of Eukaryotes (a: The Problem) ; 10. The Mysterious Birth of Eukaryotes (b: A Possible Pathway) ; 11. The Visible Revolution ; 12. The Arrow of Evolution ; 13. Becoming Human ; 14. The Riddle of the Brain ; 15. Reshaping Life ; 16. After Us, What? ; 17. Are We Alone? ; 18. How About God in All That?

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Table of ContentsPART I: Biologic and Molecular Basis for Regenerative Medicine PART II: Cells and Tissue Development PART III: Biomaterials for Regenerative Medicine PART IV: Therapeutic Applications Section A: Cell Therapy Section B: Tissue Therapy PART V: Regulation and Ethics

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Book SynopsisPraise for the prior editionThe author has done a magnificent job this book is highly recommended for introducing biophysics to the motivated and curious undergraduate student.?Contemporary Physicsa terrific text will enable students to understand the significance of biological parameters through quantitative examples?a modern way of learning biophysics. ?American Journal of PhysicsA superb pedagogical textbook Full-color illustrations aid students in their understanding ?Midwest Book ReviewThis new edition provides a complete update to the most accessible yet thorough introduction to the physical and quantitative aspects of biological systems and processes involving macromolecules, subcellular structures, and whole cells. It includes two brand new chapters covering experimental techniques, especially atomic force microscopy, complementing the updated coverage of mathematical and compTable of ContentsI. Introduction, Approach, and Tools 1 Introduction to a New World 2 How (Most) Physicists Approach Biophysics 3 Math Tools: First Pass II. Structure and Function 4 Water 5 Structures: From 0.1 to 10 nm and Larger 6 First Pass at Supramolecular Structures: Assemblies of Biomolecules 7 Putting a Cell Together: Physical Sketch III. Biological Activity: Quantum Microworld 8 Quantum Primer 9 Light, Life and Measurement 10 Photosynthesis 11 Direct Ultraviolet Effects on Biological Systems IV. Biological Activity: (Classical) Microworld 12 Classical Biodynamics and Biomechanics 13 Random Walks, Diffusion, and Polymer Conformation 14 Statistical Physics and Thermodynamics Primer 15 Reactions: Physical View 16 Molecular Machines: Introduction 17 Assembly 18 Preparation for Experimental Biophysics 19 Atomic Force Microscopy

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Book SynopsisTable of ContentsIntroduction 1 Part 1: The World of the Cell 5 Chapter 1: Exploring the World of the Cell 7 Chapter 2: Take a Tour inside the Cell 13 Chapter 3: Dead or Alive: Viruses 35 Part 2: Molecules: The Stuff of Life 51 Chapter 4: Better Living through Chemistry 53 Chapter 5: Carbohydrates: How Sweet They Are 77 Chapter 6: Proteins: Workers in the Cellular Factory 87 Chapter 7: DNA and RNA: Instructions for Life 103 Chapter 8: Lipids: Waterproof and Energy Rich 113 Part 3: The Working Cell 121 Chapter 9: Hello, Neighbor: How Cells Communicate 123 Chapter 10: Metabolism: Transferring Energy and Matter 139 Chapter 11: Cellular Respiration: Every Breath You Take 159 Chapter 12: Photosynthesis: Makin’ Food in the Kitchen of Life 187 Chapter 13: Splitsville: The Cell Cycle, Cell Division, and Cancer 203 Part 4: Genetics: From One Generation to the Next 219 Chapter 14: Meiosis: Getting Ready for Baby 221 Chapter 15: Genetics: Talkin’ ’Bout the Generations 233 Part 5: Molecular Genetics: How Cells Read the Book of Life 261 Chapter 16: DNA Replication: Doubling Your Genetic Stuff 263 Chapter 17: Transcription and Translation: What’s in a Gene? 273 Chapter 18: Control of Gene Expression: It’s How You Play Your Cards That Counts 291 Part 6: Molecular Biology: Harnessing the Power of DNA 311 Chapter 19: The Book of You: Reading Your Genes 313 Chapter 20: Rewriting the Code of Life: Recombinant DNA Technology and Genome Editing 331 Part 7: The Part of Tens 349 Chapter 21: Ten Important Rules for Cells to Live By 351 Chapter 22: Ten Ways to Improve Your Grade 361 Index 369

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Book SynopsisGet colouring and let yourself be inspired by the marvels of the microscopic world as you make your way through this fascinating and important book.' Professor Luke O'NeillThis distinctive colouring book explores the beauty of microscopic life, from vaccines and viruses to protozoa and algae. Go on a journey of scientific discovery as your colours illuminate a hidden world beyond the limits of our own vision.Bring to life the nucleocapsid protein of the Covid-19 virus, the overlapping frill of the delphinium peregrinum seed and the shell-like carapace of a water-flea as you discover the startling and unexpected beauty of life under the lens.Containing over 60 detailed illustrations from the natural world, including a coronavirus vaccine on the cover and inside, this book is a calming celebration of small science.

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Book SynopsisTrade Review"Murphy has gathered a huge amount of research material on longevity, giving the book a tone of meticulous authority" * Kirkus Reviews *"[An] informative deep dive into the research behind living longer and the aging process."---Tom Wilk, New Jersey Monthly"Meticulous. . . . [Murphy's] sweep is vast as she discourses on diet, exercise, insulin signaling and the genes that affect longevity. In her final, superb chapters, she takes on the associations between the human microbiome and cognitive deterioration, wrapping up with a look ahead to emerging drug therapies."---Hamilton Cain, Wall Street Journal"In How We Age, geneticist Coleen Murphy provides no silver bullets for remaining youthful. Rather, she offers a scholarly account of the state of ageing research that is both lively and personal. She also gives real insight into the ups and downs of leading a research laboratory. . . . How We Age will be particularly useful to researchers, but it should also appeal to general readers who want to know what it took to arrive at the current understanding of ageing — and the prospects of undergoing it in better shape."---Linda Partridge, Nature

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Book SynopsisCancer cells exist in an ever-changing âœecologyâ and are subject to evolutionary pressures just like any species in nature. This edited book explores the following themes: 1) how the dynamics of mutation, epigenetics, and gene expression noise are sources of genetic diversity; 2) how scarce resources influence cancer therapy resistance; 3) how predator-prey dynamics are mirrored in immune-cancer cross-talk; 4) how cancer cells parallel niche construction theory; 5) how changing fitness landscapes enable cancer growth; and 6) how cancer cells interact within the body. The book is a resource for understanding cancer as a disease of multicellularity grounded in evolutionary principles. By using this knowledge, researchers are starting to exploit these behaviors for treatment paradigms.Key Features Bridges disciplines exemplifying the ways disparate fields create new perspectives when integrated. Offers insights from leading scholars in cancer biology, ecolo

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Book SynopsisThe topic of stem cells has a high profile in the media. We''ve made important advances in our scientific understanding, but despite this the clinical applications of stem cells are still in their infancy and most real stem cell therapy carried out today is some form of bone marrow transplantation. At the same time, a scandalous spread of unproven stem cell treatments by private clinics represents a serious problem, with treatments being offered which are backed by limited scientific rationale, and which are at best ineffective, and at worse harmful. This Very Short Introduction introduces stem cells, exploring what they are, and what scientists do with them. Introducing the different types of stem cells, Jonathan Slack explains how they can be used to treat diseases such as retinal degeneration, diabetes, Parkinson''s disease, heart disease, and spinal trauma. He also discusses the important technique of bone marrow transplantation and some other types of current stem cell therapy, used for the treatment of blindness and of severe burns. Slack warns against fake stem cell treatments and discusses how to distinguish real from fake treatments. He also describes the latest scientific progress in the field, and looks forward to what we can expect to happen in the next few yearsVery Short Introductions: Brilliant, Sharp, Inspiring ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.Table of ContentsPreface 1: What are stem cells? 2: Embryonic stem cells 3: Personalised pluripotent stem cells 4: Therapy using pluripotent stem cells 5: Tissue-specific stem cells 6: Therapy using tissue-specific stem cells 7: Expectations: realistic and unrealistic Glossary Further Reading Index

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Book SynopsisPrinciples of Neurobiology, Second Edition presents the major concepts of neuroscience with an emphasis on how we know what we know. The text is organized around a series of key experiments to illustrate how scientific progress is made and helps upper-level undergraduate and graduate students discover the relevant primary literature. Written by a single author in a clear and consistent writing style, each topic builds in complexity from electrophysiology to molecular genetics to systems level in a highly integrative approach. Students can fully engage with the content via thematically linked chapters and will be able to read the book in its entirety in a semester-long course. Principles of Neurobiology is accompanied by a rich package of online student and instructor resources including animations, figures in PowerPoint, and a Question Bank for adopting instructors.Trade ReviewProf Liqun Luo is the recipient of the 2020 Award for Education in Neuroscience granted by the Society for Neuroscience in recognition of his continuing commitment to both cutting-edge research and neuroscience education. The first edition of his textbook has been adopted by over 150 courses taught by major universities all of the world."This textbook from Dr. Liqun Luo is fantastic for advanced undergraduate courses on neurobiology. The emphasis on experiment-led explanations of neurobiology is critical for students transiting from textbook learning to thinking like modern scientist." - Marla B. Feller, Paul Licht Distinguished Professor in Biological Sciences, Division of Neurobiology, Department of Molecular and Cell Biology & Helen Wills Neuroscience Institute, University of California, Berkeley"Principles of Neurobiology is a stellar achievement of scholarship - a synthesis of the most interesting and important discoveries in neuroscience, written by a leader in our field who has based his text on a careful reading of thousands of primary research papers. Remarkably, this book does not just describe each 'discovery': it also describes the path to discovery, noting the specific technologies and experimental designs that enabled each key result." - Rachel Wilson, Martin Family Professor of Basic Research in the Field of Neurobiology, Harvard Medical School and Investigator, Howard Hughes Medical Institute"… what an extraordinary achievement this is – I don’t think there are many out there any longer who can cover the entire field of neuroscience in such a scholarly manner, singlehandedly! The integration that results from this is likely unique to this book." - Edvard Moser, Professor of Psychology and Neuroscience, Founding Director of the Kavli Institute for Systems Neuroscience, Norwegian University of Science and TechnologyProf Liqun Luo is the recipient of the 2020 Award for Education in Neuroscience granted by the Society for Neuroscience in recognition of his continuing commitment to both cutting-edge research and neuroscience education. The first edition of his textbook has been adopted by over 150 courses taught by major universities all of the world."This textbook from Dr. Liqun Luo is fantastic for advanced undergraduate courses on neurobiology. The emphasis on experiment-led explanations of neurobiology is critical for students transiting from textbook learning to thinking like modern scientist." - Marla B. Feller, Paul Licht Distinguished Professor in Biological Sciences, Division of Neurobiology, Department of Molecular and Cell Biology & Helen Wills Neuroscience Institute, University of California, Berkeley"Principles of Neurobiology is a stellar achievement of scholarship - a synthesis of the most interesting and important discoveries in neuroscience, written by a leader in our field who has based his text on a careful reading of thousands of primary research papers. Remarkably, this book does not just describe each 'discovery': it also describes the path to discovery, noting the specific technologies and experimental designs that enabled each key result." - Rachel Wilson, Martin Family Professor of Basic Research in the Field of Neurobiology, Harvard Medical School and Investigator, Howard Hughes Medical Institute"… what an extraordinary achievement this is – I don’t think there are many out there any longer who can cover the entire field of neuroscience in such a scholarly manner, singlehandedly! The integration that results from this is likely unique to this book." - Edvard Moser, Professor of Psychology and Neuroscience, Founding Director of the Kavli Institute for Systems Neuroscience, Norwegian University of Science and TechnologyTable of Contents1. An Invitation to Neurobiology. 2. Signaling within Neurons. 3. Signaling across Synapses. 4. Vision. 5. Wiring the Visual System. 6. Olfaction, Taste, Audition, and Somatosensation. 7. Constructing the Nervous System. 8. Motor Systems. 9. Regulatory Systems. 10. Sexual Behavior. 11. Memory, Learning, and Synaptic Plasticity. 12. Brain Disorders. 13. Evolution of the Nervous System. 14. Ways of Exploring.

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Book SynopsisTable of Contents1. RNA and the Cellular Biochemistry Revisited2. Creating a Ribonuclease-free Environment3. RNA Isolation Strategies4. The Truth about Tissues5. Going Green: RNA and the Molecular Biology of Plants6. Quality Control for RNA Preparations7. cDNA: A Permanent Biochemical Record of the Cell8. RT-PCR: A Science and an Art Form9. Quantitative PCR Techniques10. miRNA11. RNA Interference - Take a RISC: Role the Dicer12. Stringency: Conditions that Influence Nucleic Acid Structure13. Electrophoresis of RNA14. Photodocumentation and Image Analysis15. Northern Analysis16. Nucleic Acid Probe Technology17. Isolation of Polyadenylated RNA18. Quantification of Specific mRNAs by Nuclease Protection19. Analysis of Nuclear RNA20. Non-Array Methods for Global Analysis of Gene Expression21. Genomes, Transcriptomes, Proteomes, and Bioinformatics22. RNA Biomarker Development23. High-Throughput Analysis of Gene Expression24: Functional Genomics and Transcript Profiling25. A Few RNA Success Stories AppendixA. Maintaining Complete and Accurate RecordsB. Converting Mass to MolesC. Disposal of Ethidium Bromide and SYBR Green SolutionsD. DNase I Removal of DNA from an RNA SampleE. RNase Incubation to Remove RNA from a DNA SampleF. Useful Stock Solutions for the Molecular BiologistG. Silanizing Centrifuge Tubes and GlasswareH. Dot Blot AnalysisI. Electrophoresis: Principles, Parameters, and SafetyJ. Polyacrylamide Gel ElectrophoresisK. Centrifugation as a Mainstream Tool for the Molecular BiologistL. Trypsinization Protocol for Anchorage-Dependent CellsM. Isolation of High-Molecular-Weight DNA by Salting-OutN. Phenol PreparationO. Deionization of Formamide, Formaldehyde, and GlyoxalP. Selected Suppliers of Equipment, Reagents, and ServicesQ. Useful SI UnitsR. Common AbbreviationsS. Trademark Citations

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Book SynopsisTable of Contents1. Functional principles and regulation of molecular chaperones Johannes Buchner 2. Chaperones and retinal disorders Nikolai O. Artemyev 3. Protein misfolding and degradation in genetic diseases Rasmus Hartmann-Petersen 4. Chaperone dysfunction in hereditary myopathic diseases Andreas Roos 5. Diseases caused by functional disorder of molecular chaperones residing in the endoplasmic reticulum Masafumi Sakono 6. Structural and functional insights on the roles of molecular chaperones in the mistargeting and aggregation phenotypes associated with primary hyperoxaluria type I Angel Luis Pey 7. Inflammatory response and its relation to sphingolipid metabolism proteins: Targeting inflammation with molecular chaperones Elif Ozkirimli 8. When safeguarding goes wrong: impact of oxidative stress on proteins homeostasis in health and neurodegenerative disorders Dana Reichmann 9. Computational approach to unravel the misfolding mechanism of Glucosylceramidase mutations in Gaucher Disease George Priya Doss P. C 10. Cytosolic quality control proteins, SGTA and the Bag6 complex, in disease Rivka L. Isaacson

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Book SynopsisTable of Contents1. Biological oxidation of iron sulfides Mathilde Monachon, Magdalena Albelda Berenguer and Edith Joseph 2. Microbes associated with fresh produce: Sources, types and methods to reduce spoilage and contamination Maciej Kaczmarek, Simon V. Avery and Ian Singleton 3. Toward rational selection criteria for selection of probiotics in pigs Weilan Wang and Michael Gänzle 4. Mucoid switch in Burkholderia cepacia complex bacteria: Triggers, molecular mechanisms and implications in pathogenesis Mirela R. Ferreira, Sara C. Gomes and Leonilde M. Moreira 5. Phenotypic instability in fungi Philippe Silar

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Book SynopsisTable of ContentsPART I – Foundations Chapter 1 – Introduction Bedir Tekinerdogan, Dominique Blouin, Hans Vangheluwe, Miguel Goulão, Paulo Carreira, Vasco Amaral Chapter 2 An Ontological Foundation for Understanding Multi-Paradigm Modeling for Cyber-Physical Systems R. Paige, M. van den Brand Chapter 3 Feature-based Survey of Cyber-Physical Systems B. Akesson, J. Hooman, R. Dekker, W. Ekkelkamp, B. Stottelaar PART II - Techniques Chapter 4 Current standards and best practices used in CPSG. Orhan & M. Aksit Chapter 5 Tools and techniques used in different disciplines for CPS development: Modeling languagesS. Schuster, I. Schaefer, C. Seidl Chapter 6 Tools and techniques used in different disciplines for CPS development: Interfaces for InteroperabilityO. Al-wadeai, A. García-Domínguez, A. Bagnato, A. Abhervé, K. Barmpis Chapter 7 Tools and techniques used in different disciplines for CPS development: ProcessesY. Luo, J. Mengerink, M. van den Brand, R. Schiffelers Chapter 8 Requirements for future MPM4CPS modelling tools and techniquesB. Tekinerdogan, D. Blouin PART III – Application Domains Chapter 9 Case Study: Alarm Detection and Monitoring of Smart Factory Environment using Hybrid Sensor Network L. Banjanovic-Mehmedovic, D. Blouin, F. Mehmedovic, M. Zukic Chapter 10 Case Study: Embedded Devices Constantin-Bala Zamfirescu and Peter Larsen Chapter 11 Case Study: SmartLab Cloud System for IoT H. Vangheluwe Chapter 12 Automated Analysis of Model-Driven Artifacts in Industry – Big Data Analytics Y. Luo, J. Mengerink, M. van den Brand, R. Schiffelers PART IV – Education Chapter 13 On a MPM4CPS CurriculaV. Amaral, M. Goulão Chapter 14Developing a mutually-recognized cross-domain study program in cyber-physical systems Paulo Carreira Glossary Author Index Subject Index

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Book SynopsisDeath, for bacteria, is not inevitable. Protect a bacterium from predators, and provide it with adequate food and space to grow, and it would continue living--and reproducing asexually--forever. But a paramecium (a slightly more advanced single-cell organism), under the same ideal conditions, would stop dividing after about 200 generations--and die. Death, for paramecia and their offspring, is inevitable. Unless they have sex. If at any point during that 200 or so generations, two of the progeny of our paramecium have sex, their clock will be reset to zero. They and their progeny are granted another 200 generations. Those who fail to have sex eventually die. Immortality for bacteria is automatic; for all other living beings--including humans--immortality depends on having sex. But why is this so? Why must death be inevitable? And what is the connection between death and sexual reproduction? In Sex and the Origins of Death, William R. Clark looks at life and death at the level of the cell, as he addresses such profound questions as why we age, why death exists, and why death and sex go hand in hand. Clark reveals that there are in fact two kinds of cell death--accidental death, caused by extreme cold or heat, starvation, or physical destruction, and programmed cell death, initiated by codes embedded in our DNA. (Bacteria have no such codes.) We learn that every cell in our body has a self-destruct program embedded into it and that cell suicide is in fact a fairly commonplace event. We also discover that virtually every aspect of a cell''s life is regulated by its DNA, including its own death, that the span of life is genetically determined (identical twins on average die 36 months apart, randomly selected siblings 106 months apart), that human tissue in culture will divide some 50 times and then die (an important exception being tumor cells, which divide indefinitely). But why do our cells have such programs? Why must we die? To shed light on this question, Clark reaches far back in evolutionary history, to the moment when inevitable death (death from ageing) first appeared. For cells during the first billion years, death, when it occurred, was accidental; there was nothing programmed into them that said they must die. But fierce competition gradually led to multicellular animals--size being an advantage against predators--and with this change came cell specialization and, most important, germ cells in which reproductive DNA was segregated. When sexual reproduction evolved, it became the dominant form of reproduction on the planet, in part because mixing DNA from two individuals corrects errors that have crept into the code. But this improved DNA made DNA in the other (somatic) cells not only superfluous, but dangerous, because somatic DNA might harbour mutations. Nature''s solution to this danger, Clark concludes, was programmed death--the somatic cells must die. Unfortunately, we are the somatic cells. Death is necessary to exploit to the fullest the advantages of sexual reproduction. In Sex and the Origins of Death, William Clark ranges far and wide over fascinating terrain. Whether describing a 62-year-old man having a major heart attack (and how his myocardial cells rupture and die), or discussing curious life-forms that defy any definition of life (including bacterial spores, which can regenerate after decades of inactivity, and viruses, which are nothing more than DNA or RNA wrapped in protein), this brilliant, profound volume illuminates the miraculous workings of life at its most elemental level and finds in these tiny spaces the answers to some of our largest questions.Trade ReviewAnyone who reckons that science writing is dry stuff may find their outlook broadened by this little book about the biology of death. * New Scientist *

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Book SynopsisIn Life Itself, Boyce Rensberger, science writer for The Washington Post, takes readers to the frontlines of cell research with some of the brightest investigators in molecular, cellular, and developmental biology. Virtually all the hottest topics in biomedical research are covered here, such as how do cells and their minute components move How do the body''s cells heal wounds? What is cancer? Why do cells die? And what is the nature of life? The solutions to the most pressing challenges facing scientists today -- from the efforts to conquer disease to the quest to understand life itself -- will be found in the innermost workings of the cell.In Life Itself, Rensberger paints a colourful and fascinating portrait of modern research in this vital area, an account which will enthrall anyone interested in state-of-the-art science or the incredible workings of the human body.Trade ReviewLife Itself is a wonderfully readable digest of everything currently known about the mechanisms by which living cells perform their myriad tasks. * The New York Times Book Review *An elegant, authoritative, yet felicitously written book that will appeal to anyone who is interested in how cells work....a compelling portrait of terrestrial life in its many guises. * New Scientist *Table of Contents1. A Particle of Life ; 2. Molecular Motors ; 3. Animation ; 4. The Living-Room Cell ; 5. How Genes Work ; 6. One Life Becomes Two ; 7. Two lives Become One ; 8. Constructing a Person ; 9. Pumping Protein ; 10. Heal Thyself ; 11. In Self-Defense ; 12. Revolution ; 13. The Immortality Within

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Book SynopsisWhat is life? Fifty years after physicist Erwin Schrodinger posed this question in his celebrated and inspiring book, the answer remains elusive. In The Way of the Cell, one of the world''s most respected microbiologists draws on his wide knowledge of contemporary science to provide fresh insight into this intriguing and all-important question. What is the relationship of living things to the inanimate realm of chemistry and physics? How do lifeless but special chemicals come together to form those intricate dynamic ensembles that we recognize as life? To shed light on these questions, Franklin Harold focuses here on microorganisms - in particular, the supremely well-researched bacterium E. coli - because the cell is the simplest level of organization that manifests all the features of the phenomenon of life. Harold shows that as simple as they appear when compared to ourselves, every cell displays a dynamic pattern in space and time, orders of magnitude richer than its elements. It integrates the writhings and couplings of billions of molecules into a coherent whole, draws matter and energy into itself, constructs and reproduces its own order, and persists in this manner for numberless generations while continuously adapting to a changing world. A cell constitutes a unitary whole, a unit of life, and in this volume one of the leading authorities on the cell gives us a vivid picture of what goes on within this minute precinct. The result is a richly detailed, meticulously crafted account of what modern science can tell us about life as well as one scientist''s personal attempt to wring understanding from the tide of knowledge.Trade Review"The work is like a breath of fresh air in a scientific world otherwise obsessed with excessive reductionism."--BioEssays"Witty and erudite, this scientific book hails as a literary achievement. Comprehensive and up to date, Franklin Harold traces the roots--historical, thermodynamic, and biochemical--of today's biological revolution."--Lynn Margulis, co-author (with Dorion Sagan) of both What is Life? and What is Sex?"This book helps us understand why the search for answers to the riddle 'What is life?' is a noble quest."--Howard C. Berg, author of Random Walks in Biology

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Book SynopsisNeural network research often builds on the fiction that neurons are simple linear threshold units, completely neglecting the highly dynamic and complex nature of synapses, dendrites, and voltage-dependent ionic currents. Biophysics of Computation: Information processing in single neurons challenges this notion, using richly detailed experimental and theoretical findings from cellular biophysics to explain the repertoire of computational functions available to single neurons. The author shows how individual nerve cells can multiply, integrate, or delay synaptic inputs and how information can be encoded in the voltage across the membrane, in the intracellular calcium concentration, or in the timing of individual spikes.Key topics covered include the linear cable equation; cable theory as applied to passive dendritic trees and dendritic spines; chemical and electrical synapses and how to treat them from a computational point of view; nonlinear interactions of synaptic input in passive anTable of Contents1. The membrane equation ; 2. Linear cable theory ; 3. Passive dendritic trees ; 4. Synaptic input ; 5. Synaptic interactions in a passive dendritic tree ; 6. The Hodgkin-Huxley model of action-potential generation ; 7. Phase space analysis of neuronal excitability ; 8. Ionic channels ; 9. Beyond Hodgkin and Huxley: calcium, and calcium-dependent potassium currents ; 10. Linearizing voltage-dependent currents ; 11. Diffusion, buffering, and binding ; 12. Dendritic spines ; 13. Synaptic plasticity ; 14. Simplified models of individual neurons ; 15. Stochastic models of single cells ; 16. Bursting cells ; 17. Input resistance, time constants, and spike initiation ; 18. Synaptic input to a passive tree ; 19. Voltage-dependent events in the dendritic tree ; 20. Unconventional coupling ; 21. Computing with neurons - a summary

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Book SynopsisCryoelectron microscopy of biological molecules is among the hottest growth areas in biophysics and structural biology at present, and Frank is arguably the most distinguished practitioner of this art. CryoEM is likely over the next few years to take over much of the structural approaches currently requiring X-ray crystallography, because one can now get good and finely detailed images of single molecules down to as little as 200,000 MW, covering a substantial share of the molecules of greatest biomedical research interest. This book, the successor to an earlier work published in 1996 with Academic Press, is a natural companion work to our forthcoming book on electron crystallography by Robert Glaeser, with contributions by six others, including Frank. A growing number of workers will employ CryoEM for structural studies in their own research, and a large proportion of biomedical researchers will have a growing interest in understanding what the capabilities and limits of this approachTable of Contents1: Introduction 2: Electron Microscopy of Macromolecular Assemblies 3: Two-Dimensional Averaging Techniques 4: Multivariate Data Analysis and Classification of Images 5: Three-Dimensional Reconstruction 6: Interpretation of Three-Dimensional Images of Macromolecules Appendix 1: Some Important Definitions and Theorems Appendix 2: Profiles, Point-Spread Functions, and Effects of Commonly Used Low-Pass Filters Appendix 2: Bibliography of Methods Appendix 2: Bibliography of Structures Appendix 2: Special Journal Issues on Image Processing Techniques

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Book SynopsisLeaves are among the most abundant organs on earth and are a defining feature of most terrestrial ecosystems. However, a leaf is also a potential meal for a hungry animal and the question therefore arises, why does so much foliage survive in nature? What mechanisms protect leaves so that, on a global scale, only a relatively small proportion of living leaf material is consumed? Leaf survival is in large part due to two processes: firstly, leaf-eating organisms fall prey to predators (top-down pressure on the herbivore); secondly, leaves defend themselves (bottom-up pressure on the herbivore). Remarkably, these two types of event are often linked; they are controlled and coordinated by plants and the molecular mechanisms that underlie this are now beginning to emerge. This novel text focuses exclusively on the leaf, on the herbivorous organisms that attack leaves, and the mechanisms that plants use to defend these vital organs. It begins with an assessment of the scale of herbivory, befTrade ReviewAn essential resource for graduate students and faculty and valuable for upper-division undergraduates. * Choice *Leaf Defence provides an excellent review of the rapidly evolving literature in this field. * Ian T. Baldwin, Nature Review *In a very succinct yet comprehensive format, Farmer explores the remarkably diverse means by which leaves defend themselves against herbivores ... As a guide, Farmer is engaging, authoritative and didactic ... [His] text is an enjoyable read for anyone interested in plant defences with an evolutionary perspective, accessible to a general audience from students studying ecological courses to interested biologists and biochemists. * Maria Jose Endara and Natasha L. Wiggins, Edinburgh Journal of Botany *Leaf Defence ... definitively provides the perfect read for beginners in the field to get up to date and, more importantly, sparks interest that will motivate to follow through with some of the questions. However, it also provides a very helpful overall conceptual framework that integrates and balances the very diverse scientific approaches and views in the field, which will make the volume also valuable to experienced researchers as a guideline and reference. The structure of the book is ingenious in its simplicity and logic. * Andre Kessler, Quarterly Review of Biology *Table of Contents1. Introduction: The leaf and the pressures it faces ; 2. Leaf colour patterning and leaf form ; 3. Structural defences and specialised defence cells ; 4. Chemical defences ; 5. Inducible defences and the jasmonate pathway ; 6. Top-down pressures and indirect defences ; 7. Release and escape from herbivory ; 8. Escape in space : The cliff trees of Socotra

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Book SynopsisA fresh approach to biology centred on a clear narrative, active learning, and confidence with quantitative concepts and scientific enquiry. Designed for flexible learning, it will give you a deeper understanding of the key concepts, and an appreciation of biology as a dynamic experimental science.Table of ContentsLife and its Exploration: Foundational Principles Topic 1: Exploring the science of life Topic 2: The emergence of life on Earth Topic 3: Defining Life Topic 4: Evolutionary processes Topic 5: The diversity, organisation, and classification of life Quantitative Toolkits Quantitative Toolkit 1: Understanding data Quantitative Toolkit 2: Size and scale Quantitative Toolkit 3: Describing data Quantitative Toolkit 4: Ratio and proportion Quantitative Toolkit 5: Understanding samples Quantitative Toolkit 6: Designing experiments Quantitative Toolkit 7: Assessing patterns Quantitative Toolkit 8: Formulae and equations Quantitative Toolkit 9: Rates of change Module 1 LIFE AT THE MOLECULAR LEVEL 1: Building blocks: molecules and macromolecules 2: Energy: powering biochemical processes 3: Information: genes and genomes 4: Mendelian genetics 5: Reading the genome: gene expression and protein synthesis 6: Proteins and proteomes 7: Metabolism: energy capture and release from food 8: Molecular tools and techniques Module 2 LIFE AT THE CELLULAR LEVEL 9: Characteristics of prokaryotic and eukaryotic cells 10: Cell division in prokaryotes and eukaryotes 11: Microbial diversity 12: The growth, measurement, and visualisation of cells 13: Microbes in life: harnessing their power 14: Microbes as agents of infectious disease 15: Viruses Module 3 THE HUMAN ORGANISM: TISSUES, ORGANS, AND SYSTEMS 16: Physiology overview 17: Communication and control 1: introducing the nervous and endocrine systems 18: Communication and control 2: sensory systems 19: Communication and control 3: controlling organ systems 20: Muscle and movement 21: Cardiovascular system 22: Respiratory system 23: Exercise physiology 24: Renal system 25: Digestive system 26: Reproductive system 27: Immune system

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Book SynopsisWritten primarily for students embarking on an undergraduate bioscience degree, this primer provides a clear introduction to the main aspects of cell signalling in biological systems, demystifying the subject for those new to the field. The primer provides an overview of cell signalling and highlights its importance in all organisms, before going on to describe the main components of cell signalling and examples of signal transduction pathways. The discussion then progresses on to key physiological conditions in which cell signalling has an instrumental role: cancer, apoptosis and diabetes. After getting to grips with the fundamentals of the subject, Cell Signalling opens a discussion on the future of the discipline, including how manipulation of cell signalling pathways is seen as the biggest target for the pharmaceutical industry, and how crop diseases, plant survival during stress, and post-harvest storage are all influenced by cell signalling pathways.Cell Signalling is supported bTable of Contents1: Introduction to cell signalling 2: Signals and their perception 3: Modifications to proteins that control cell signalling 4: Intracellular signals 5: Cell signalling disorders; cancers and apoptosis 6: Stress responses and the changing cell environment 7: Future challenges and perspectives in cell signalling

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Book SynopsisWritten primarily for 16-19-year-old students, this primer introduces the subject of developmental biology through a wide range of organisms, offering insights into the fundamental principles that shape life''s diverse and extraordinary forms. It covers all the essential topics, including cell biology, cell signalling, cell specialization, genomic control of development, evidence for evolution, and cell ageing and death.The author guides students carefully and gradually through the concise contents, providing a robust basis for understanding the molecular and morphological events that occur during embryo development, but that are also important in adult homeostasis, regeneration, and disease. Students will delve into the secrets of stem cells, the marvels of regeneration, and the paradox of how a broadly conserved genome can support the biodiversity we see throughout the natural world. Engaging case studies and ''scientific approach'' boxes challenge the reader to think critically and Table of Contents1: Why aren't we all worms? 2: How and why do cells talk to each other? 3: The secret lives of stem cells 4: Embryo origami 5: Creating diverse and extreme body plans 6: The good, the bad, and the old: developmental principles in regeneration and ageing

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Book SynopsisIntroduction to Glycobiology reveals the true impact of the sugars on biological systems, explaining their function at the molecular, cellular, and organismal level and their clinical relevance.Trade ReviewReview from previous edition This book is an absolute must for all lecturers and students alike of glycobiology ... Wholeheartedly recommended. * Microbiology Today, November 2006 *It covers the breadth of glycobiology very well and provides sufficient depth to provide a platform for further research. * Dr Gavin M. Brown, Lancaster University *Others are not written as clearly or concisely as Taylor and Drickamer. * Prof Y.C. Lee, John Hopkins University *I prefer this book highly above the other text books available. * Prof Dr J.P. Kamerling, Utrecht University *Dr Taylor and Professor Drickamer should be congratulated on writing a textbook that presents the enormous subject of glycobiology with energy and enthusiasm and doing so in a manner that should be accessible to their target audience. * Biochemist e-volution, April 2006 *Table of ContentsPART 1: STRUCTURES AND BIOSYNTHESIS OF GLYCANS; PART 2: GLYCANS IN BIOLOGY

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Book SynopsisSignalling within and between cells is one of the most important aspects of modern biochemistry and cell biology. An understanding of signalling pathways is vital to a wide range of biologists, from those who are investigating the causes of cancer, to those who are concerned about the impact of environmental pollutants on the ecosystem. The way cells adapt to changing environments, and the way cell dysfunction causes disease, is underpinned by cell signalling events. Cell Signalling presents a carefully structured and highly accessible introduction to this intricate and rapidly growing field. Starting with an overview of cell signalling and highlighting its importance in many biological systems, the book goes on to explore the key components of extracellular and intracellular signalling mechanisms, before examining how these components come together to create signalling pathways. A focus on common components and concepts, rather than mechanistic detail, allows the reader to gain a thorough understanding of the principles that underpin cell signalling. Online Resource CentreThe Online Resource Centre to accompany Cell Signalling features:For students:- Links to useful websitesFor registered adopters of the text:- Journal Clubs: suggested research papers and discussion questions linked to topics featured in the book- Figures from the book in electronic format for use in lecturesTrade ReviewA good overview of the key underlying concepts and principles, allowing students to gain a solid grounding in the subject. I like the Case Study sections which link to research findings; these provide relevant context and help students to understand the key message in complex scientific articles. * Dr Andrew Chantry, University of East Anglia *It is really the best specialist text for undergraduates on this topic I have seen. * Dr Fergus Doherty, University of Nottingham *Review from previous edition: John Hancock's Cell Signalling is a straightforward introduction to a rapidly expanding field of biology. Its unintimidating writing style, simple and uncluttered figures, and competitive price make it a wonderful introductory text for undergraduates. * Dr Laura K. Palmer, Penn State University *Review from previous edition: Complexity and specificity are the hallmarks of cell signalling, yet Hancock in this third edition has gone a long way to simplify these complicated processes. His signalling examples are clever and well-conceived, his writing descriptive and his passion for his subject infectious ... this is marvellous value for money and is a worthy companion to an undergraduate/postgraduate reference library. * John P. Phelan, Waterford Institute of Technology, Ireland in The Biochemist *Table of ContentsPART 1: AN OVERVIEW OF SIGNALLING; PART 2: COMPONENTS THAT COMPRISE SIGNALLING PATHWAYS; PART 3: SELECTED EXAMPLES OF SIGNALLING PATHWAYS AND EVENTS; PART 4: FINAL THOUGHTS

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Book SynopsisThe Fourth Edition of The Neuron features newly updated chapters and scores of full-color figures, making it an ideal first course in the cell and molecular biology of nerve cells.Trade ReviewThe text is impressively modern, with up-to date information on the trendiest areas of neurobiology . . .the book is highly visual, with figures on virtually every page. The figures deserve special comment because they are a teacher's dream: simple and uncluttered, but conceptually powerful. Frankly, although the recommendation is often absurd, The Neuron is one of those books that really does belong on every shelf. * Nature *The format of each chapter is ideally suited for easy, enjoyable, and almost effortless learning . . . This is a superbly written and well-illustrated text covering all of the major aspects of neuroscientific knowledge . . . every neuroscientist should keep a copy handy. * Journal of Psychiatry and Neuroscience *This is a first-rate textbook for a course in cellular neurobiology for upper-level university students. My colleagues and I took it out on a shakedown cruise with a class of 250 undergraduates. The wind really caught their sails, and we sped quickly through it in the ten weeks of the academic quarter. The students appreciated the consistent clarity and the uniformity of style. The illustrations are highly conceptual and were easily understood . . . The up-to-date presentation of many exciting recent findings is a great strength. General principles are illustrated with a useful blend of data from vertebrate and invertebrate systems. * William S Messer, Jr., in The Quarterly Review of Biology *An outstanding, easily readable, and quite up-to-date overview of fundamental neurobiology. * Canadian Journal of Neurological Sciences *Table of ContentsPreface to the Fourth Edition ; I. Introduction ; 1. Signaling in the Brain ; 2. Form and Function in Cells of the Brain ; II. Electrical Properties of Neurons ; 3. Electrical Signaling in Neurons ; 4. Membrane Ion Channels and Ion Currents ; 5. Ion Channels Are Membrane Proteins ; 6. Ion Channels, Membrane Ion Currents, and the Action Potential ; 7. Diversity in the Structure and Function of Ion Channels ; III. Intercellular Communication ; 8. Intercellular Communication: How Neurons Communicate: Gap Junctions and Neurosecretion ; 9. Synaptic Release of Neurotransmitters ; 10. Neurotransmitters and Neurohormones ; 11. Receptors and Transduction Mechanisms I: Receptors Coupled Directly to Ion Channels ; 12. Receptors and Transduction Mechanisms II: Indirectly Coupled Receptor/Ion Channel Systems ; 13. Sensory Receptors ; IV. Behavior and Plasticity ; 14. The Birth and Death of a Neuron ; 15. Neuronal Growth and Trophic Factors ; 16. Adhesion Molecules and Axon Pathfinding ; 17. Formation, Maintenance, and Plasticity of Chemical Synapses ; 18. Intrinsic Neuronal Properties, Neural Networks and Behavior ; 19. Learning and Memory

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Book SynopsisThe origin of cells remains one of the most fundamental problems in biology, one that over the past two decades has spawned a large body of research and debate. This book offers a comprehensive, impartial take on that research and the controversies that keep the field in turmoil.Trade Review"This book is a rare pleasure: a beautiful, rational, wise, and eloquent framing of life's greatest mysteries, what remains to be known, and how we might get there. It should be read by anyone who wonders, seriously, how we came to be. If it does not provide all the answers, that is because we honestly do not know." (Nick Lane, University College London)"

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Book SynopsisAn analysis of the role of metaphor in shaping the work and findings of science, using cell biology as the central case study.

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Book SynopsisAn analysis of the role of metaphor in shaping the work and findings of science, using cell biology as the central case study.

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Book SynopsisAllometry, the study of the growth rate of an organism's parts in relation to the whole, has produced various results in research on animals. This text applies allometry to studies of the evolution, morphology, physiology and reproduction of plants.Table of Contents1 Growth and Metabolism Introduction Growth and Development/Multicellularity and Modular Construction Size and Shape Scaling Principles/Dimensional Analysis The 2/3-Power Law The 3/4-Power Law Growth and Time Photosynthesis and Two Physical Laws Organs versus Organisms Summary 2 Aquatic Plants Introduction Absorption Coefficients of Water and Plant Cells The Package Effect and the Scaling of Cell Geometry and Shape The Transport Equations and Dimensionless Groupings of Variables Fluid Flow and Mass and Heat Transport: Phytoplankton Self-Propulsion: The Volvocales The Mechanics of Ciliary Motion Hydrodynamic Forces and the Mechanics of Attached Aquatic Plants Summary 3 Terrestrial Plants Introduction Heat and Mass Transfer and Boundary Layer Resistances Stomatal Resistances The Mechanical Scaling of Foliage Leaves Mechanical Design: General Considerations The Mechanical Scaling of Tree Height The Mechanical Scaling of Other Terrestrial Plants The Scaling of Self-Thinning Summary 4 Reproduction Introduction The Scaling of Reproductive Biomass Flowers, Fruits, and Seeds Branches and Reproductive Structures The Scaling of Long-Distance Dispersal Size and Gender Expression Summary 5 Evolution Introduction Heterochrony Heterauxesis and Allomorphosis On Being Small or Large The Scaling of the Plant Life Cycle The Evolution of Plant Life Histories Summary

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Book SynopsisAllometry, the study of the growth rate of an organism's parts in relation to the whole, has produced various results in research on animals. This text applies allometry to studies of the evolution, morphology, physiology and reproduction of plants.

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Book SynopsisTrade Review"That life is connected to death, and to evolution, is incontrovertible. But what might be the connection between death and evolution? That is, might death be an adaptation? That’s the startling conclusion reached by Durand in this brief volume, which combines philosophy, biological theory, and empirical science in often thrilling ways... Durand thinks big thoughts but is careful, in his prose, to involve readers whose interest in theoretical biology exceeds their grasp. A very important book. Highly recommended." * Choice Connect *"[The Evolutionary Origins of Life and Death] constitutes an impressive effort to integrate into a unified and coherent framework different and dispersed pieces of empirical work about how life and death emerged on Earth, and about how these two phenomena coevolved to become deeply entangled." * History and Philosophy of Life Sciences *“An eye opener for many readers, biologists, and others interested in visiting the frontiers of today’s conceptual thinking on evolution. This book, compact and simple but densely packed with information and ideas, presents the new edifice of evolutionary biology, a vibrant, progressing field that goes far beyond the confines of neo-Darwinism.” -- Eugene V. Koonin, National Center for Biotechnology Information, from the foreword“There is no question that Durand is deeply learned. The way that he lays out his argument linking life and death is certainly innovative and I am sure will attract attention. Insightful and stimulating, The Evolutionary Origins of Life and Death will forward discussion on important issues.” -- Michael Ruse, Florida State UniversityTable of ContentsForeword (by Eugene V. Koonin) Preface List of abbreviations An introduction to the scientific study of life and deathPart One: The origin of life 1 Philosophical considerations and the origin of life 2 The biotic world 3 The theory of life’s origins 4 Life at the very beginning I: the chemistry of the first biomolecules 5 Life at the very beginning II: the emergence of complex RNA molecules 6 The origin of life was an evolutionary transition in individuality 7 A synthesis for the origin of lifePart Two: The origin of death 8 Philosophical considerations and the origin of death 9 Observations of death 10 Mechanisms and measures of programmed cell death in the unicellular world 11 True PCD: when PCD is an adaptation 12 Ersatz PCD: the non-adaptive explanations for PCD 13 Programmed cell death and the levels of selection 14 A synthesis for the origin of programmed cell deathPart Three: Origins of life and death, and their coevolution 15 Group selection and the origins of life and death 16 Life and death coevolution, and the emergence of complexity Postface Additional notes Reference list Index

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Book SynopsisTrade Review"That life is connected to death, and to evolution, is incontrovertible. But what might be the connection between death and evolution? That is, might death be an adaptation? That’s the startling conclusion reached by Durand in this brief volume, which combines philosophy, biological theory, and empirical science in often thrilling ways... Durand thinks big thoughts but is careful, in his prose, to involve readers whose interest in theoretical biology exceeds their grasp. A very important book. Highly recommended." * Choice Connect *"[The Evolutionary Origins of Life and Death] constitutes an impressive effort to integrate into a unified and coherent framework different and dispersed pieces of empirical work about how life and death emerged on Earth, and about how these two phenomena coevolved to become deeply entangled." * History and Philosophy of Life Sciences *“An eye opener for many readers, biologists, and others interested in visiting the frontiers of today’s conceptual thinking on evolution. This book, compact and simple but densely packed with information and ideas, presents the new edifice of evolutionary biology, a vibrant, progressing field that goes far beyond the confines of neo-Darwinism.” -- Eugene V. Koonin, National Center for Biotechnology Information, from the foreword“There is no question that Durand is deeply learned. The way that he lays out his argument linking life and death is certainly innovative and I am sure will attract attention. Insightful and stimulating, The Evolutionary Origins of Life and Death will forward discussion on important issues.” -- Michael Ruse, Florida State UniversityTable of ContentsForeword (by Eugene V. Koonin) Preface List of abbreviations An introduction to the scientific study of life and deathPart One: The origin of life 1 Philosophical considerations and the origin of life 2 The biotic world 3 The theory of life’s origins 4 Life at the very beginning I: the chemistry of the first biomolecules 5 Life at the very beginning II: the emergence of complex RNA molecules 6 The origin of life was an evolutionary transition in individuality 7 A synthesis for the origin of lifePart Two: The origin of death 8 Philosophical considerations and the origin of death 9 Observations of death 10 Mechanisms and measures of programmed cell death in the unicellular world 11 True PCD: when PCD is an adaptation 12 Ersatz PCD: the non-adaptive explanations for PCD 13 Programmed cell death and the levels of selection 14 A synthesis for the origin of programmed cell deathPart Three: Origins of life and death, and their coevolution 15 Group selection and the origins of life and death 16 Life and death coevolution, and the emergence of complexity Postface Additional notes Reference list Index

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Book SynopsisExplore the miracles of the microscopic world.Find out all about the unique and beautiful kingdoms of life at a microscopic scale and how every organism meets the challenges of survival no matter its size. The perfect book for people who enjoy photography, nature, and biology.Inside the pages of this exciting nature book, you''ll find: - Microscopic life-forms (often neglected), and their larger life-forms in extreme close-ups, revealing details such as nerve cells and hair follicles - Artworks support the beautiful images, providing a deeper insight into structure and function and building a picture of how living organisms work at a microscopic level - Comprehensive coverage of the natural world, including all the main groups of living things- Explores overlooked groups that have a huge role in the natural world: insects, which make up 80 percent of the world''s animal species; and bacteria - of which there are more in a human mouth

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Book SynopsisThis volume brings together essays by an internationally distinguished and diverse group of scholars. Contributors thoughtfully explore the ethical, public policy, and scientific implications of embryonic and adult stem cell research. Part one of the book offers a variety of scientific and public policy perspectives, including essays on stem cell plasticity and using umbilical cord blood as an alternative source of pluripotent stem cells. Part two vigorously examines the ethics of stem cell research and considers issues of social justice, morality, and public policy. Scientific alternatives, a natural law perspective regarding federal funding, and a discussion of the possible moral complicity of Catholic researchers are among the distinctive contributions made to the stem cell research debate by this collection. The objective and balanced discussions contained in this volume serve as an accessible introduction to the bioethical questions, issues, and problems surroundiTrade Review“This collection covers a broad range of scientific, ethical, and public policy issues. Some articles provide general background and information, while others make highly original contributions to the ongoing debate. Ethical issues are discussed knowledgeably from a variety of religious and philosophical perspectives. Thoughtful disagreements among authors illustrate the difficulty of reaching a consensus on public policy.” —Carol A. Tauer, Professor of Philosophy Emerita, The College of St. Catherine, St. Paul, MN"In the book, Stem Cell Research, Nancy Snow provides a collection of essays that discuss different aspects of the stem cell debate. This is an important endeavor. . ." —Dialogue". . . this collection of essays is sure to speak to readers on either side of this divisive issue." —NationalJournal.com"[Stem Cell Research] provides a useful primer for many. . . of the ethical issues presented by the embryonic stem cell debate." —The Quarterly Review of Biology“This collection is an important resource for any bioethics course.” —Theological Studies“. . . so volatile and dynamic are the variables in the debates over this type of research, it would be a mistake not to look upon it as having lasting value. The authors are attentive to cutting edge science to be sure, but they effectively raise up time-tested principles from biomedical ethics and the natural law tradition in an effort to weigh the pros and cons.” —Catholic Library World“Snow’s volume is earnest . . . a plea for ethically informed science.” —Times Literary Supplement“. . . the contributions are thought-provoking and the arguments need to be addressed by proponents of the research.” —Conscience“This volume is a collection of ten essays developed out of a 2001 conference . . . the gathering convened scientists and ethicists to discuss scientific, public policy, and ethical issues concerning human stem cell research . . . the essays offer a wide range of topics, analyses, and arguments, and, as a whole, exhibit some of the complexity of issues involved in discussing human stem cell research-human embryonic stem cell research in particular. As such, the volume is an excellent introduction to the nuanced contours of this contentious realm.” —Pro Ecclesia

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Book SynopsisTable of Contents1 Front Matter; 2 Part I: CURRENT STUDY OF THE MINDBRAIN RELATIONSHIPS; 3 1 Theory of Mind and Darwin's Legacy--John Searle; 4 2 Affiliation, Empathy, and the Origins of Theory of Mind--Robert M. Seyfarth and Dorothy L. Cheney; 5 3 Evolution of Consciousness: Phylogeny, Ontogeny, and Emergence from General Anesthesia--George A. Mashour and Michael T. Alkire; 6 Part II: THE PRIMATE EVOLUTIONARY CONTINUITY; 7 4 Similarity in Form and Function of the Hippocampus in Rodents, Monkeys, and Humans--Robert E. Clark and Larry R. Squire; 8 5 Evolution of Working Memory--Peter Carruthers; 9 6 The Evolution of Episodic Memory--Timothy A. Allen and Norbert J. Fortin; 10 7 Neuroethology of Primate Social Behavior--Steve W. C. Chang, Lauren J. N. Brent, Geoffrey K. Adams, Jeffrey T. Klein, John M. Pearson, Karli K. Watson, and Michael L. Platt; 11 8 Synaptogenesis and Development of Pyramidal Neuron Dendritic Morphology in the Chimpanzee Neocortex Resembles Humans--Serena Bianchi, Cheryl D. Stimpson, Tetyana Duka, Michael D. Larsen, William G. M. Janssen, Zachary Collins, Amy L. Bauernfeind, Steven J. Schapiro, Wallace B. Baze, Mark J. McArthur, William D. Hopkins, Derek E. Wildman, Leonard Lipovich, Christopher W. Kuzawa, Bob Jacobs, Patrick R. Hof, and Chet C. Sherwood; 12 Part III: THE HUMAN DIFFERENCE: FROM ETHICS TO AESTHETICS; 13 9 Making Lasting Memories: Remembering the Significant--James L. McGaugh; 14 10 Concepts and Implications of Altruism Bias and Pathological Altruism--Barbara A. Oakley; 15 11 Justice- and Fairness-Related Behaviors in Nonhuman Primates--Sarah F. Brosnan; 16 12 Powering Up with Indirect Reciprocity in a Large-Scale Field Experiment--Erez Yoeli, Moshe Hoffman, David G. Rand, and Martin A. Nowak; 17 13 From Perception to Pleasure: Music and Its Neural Substrates--Robert J. Zatorre and Valorie N. Salimpoor; 18 14 Learning Where to Look for a Hidden Target--Leanne Chukoskie, Joseph Snider, Michael C. Mozer, Richard J. Krauzlis, and Terrence J. Sejnowski; 19 15 Impact of Contour on Aesthetic Judgments and Approach-Avoidance Decisions in Architecture-Oshin Vartanian, Gorka Navarrete, Anjan Chatterjee, Lars Brorson Fich, Helmut Leder, Cristin Modroo, Marcos Nadal, Nicolai Rostrup, and Martin Skov; 20 16 Dynamics of Brain Networks in the Aesthetic Appreciation--Camilo J. Cela-Conde, Juan Garca-Prieto, Jos J. Ramasco, Claudio R. Mirasso, Ricardo Bajo, Enric Munar, Albert Flexas, Francisco del-Pozo, and Fernando Maest; 21 References; 22 Index

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Book SynopsisKey features: High quality full color photographs and descriptive texts on the location and removal of the organs from the mouse Instructive methods and clear visuals for trimming and orienting the organs for paraffin histology to obtain the best possible sections for analysis Full color photomicrographs of the resulting section for each organ stained with hematoxylin and eosin demonstrating important features and landmarks for the histologist to ensure the optimal area for analysis is achieved All in one, easy to use guide organized by individual organs of the laboratory mouse Spiralbound for easy reference in the lab This one-stop guide offers an essential resource for any academic, research or development operation where mouse necropsy and/or histology are performed. Connecting the reader âfrom the mouse to the microscopeâ, it provides a detailed guide for locating, trimming, orientating and embedding of the most frequently investigated tissues collected in the laboratory mouse. It shows where the organs reside in the mouse, how to trim and embed them as well as the resulting optimal sections. This guide brings together the wealth of scattered information into one high-quality text, the emphasis is on providing knowledge that will help histologists and scientists get better results in any downstream assays where ideal sections are needed.Table of ContentsIntroduction. Adrenal glands. Brain. Brain: Trimming for coronal sections. Brain: Trimming for sagittal sections. Diaphragm. Esophagus, Trachea and Thyroid. Eyes. Female: Ovaries. Female: Uterus (uterine horn), cervix, vagina. Femur. Heart. Kidneys. Liver and Gallbladder. Lung (inflated). Lymph nodes: Axillary. Lymph nodes: Mesenteric. Male: Epididymes. Male: Preputial gland. Male: Seminal vesicle, coagulating gland and prostate. Male: Testes. Pancreas. Pituitary gland. Quadriceps. Salivary glands. Sciatic nerve. Skin with (or without) mammary gland. Spinal cord. Spine. Spleen. Sternum. Stomach: Open method. Stomach: Whole method. Stifle joint. Thymus. Tongue. Urinary bladder. Intestines. Small intestine: Duodenum. Small intestine: Jejunum. Small intestine: Ileum. Large intestine: Cecum. Large intestine: Colon. Large intestine: Rectum. Materials and Methods. References.

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Book SynopsisCell Signaling provides undergraduate and graduate students with the conceptual tools needed to make sense of the dizzying array of pathways that cells use to detect, process, and respond to signals from the environment. By emphasizing the common design principles and molecular processes that underlie all signaling mechanisms, the book develops a broad conceptual framework through which students can understand diverse signaling pathways and networks. The book first examines the common currencies of cellular information processing and the core components of the signaling machinery. It then shows how these individual components link together into networks and pathways to perform more sophisticated tasks. Many specific examples are provided throughout to illustrate common principles, and to provide a comprehensive overview of major signaling pathways.Thoroughly revised, this second edition includes two new chapters and substantial updates to the text and figures through

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Book SynopsisFew, if any, genes have had the same level of impact on the field of evolutionary-developmental biology (evo-devo) as the Hox genes. These genes are renowned for their roles in patterning the body plans and development of the animal kingdom. This is complemented by the distinctive organisation of these genes in the genome, with them frequently being found as clusters in which gene position is linked to when and where the individual genes are expressed, particularly during embryogenesis. This book provides the latest overviews of Hox gene organisation and function for major clades of animals from across the animal kingdom. With the rapidly increasing availability of high-quality whole genome sequences from an ever-expanding range of species, it is becoming increasingly evident that there is great diversity in the organisation of Hox genes. These great strides in genome sequencing are wedded to important developments in our ability to detect expression and disrupt gene function in speTable of ContentsSeries Preface. Preface. About the Editor. Contributors. Introduction to Hox Modules in Evolution and Development. Multiple Layers of Complexity in the Regulation of the Bithorax Complex of Drosophila. The Role of Hox Genes in the Origins and Diversification of Beetle Horns. Duplication and Evolution of Hox Clusters in Chelicerata (Arthropoda). Structural Constraints in Hox Clusters: Lessons from Sharks and Rays. Evolution of Cyclostome Hox Clusters. Hox Genes in Echinoderms. Hox Genes in Mollusca. The Evolution of Hox Genes in Spiralia. Index.

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Book SynopsisThe origin story and emergence of molecular biology is muddled. The early triumphs in bacterial genetics and the complexity of animal and plant genomes complicate an intricate history. This book documents the many advances, as well as the prejudices and founder fallacies. It highlights the premature relegation of RNA to simply an intermediate between gene and protein, the underestimation of the amount of information required to program the development of multicellular organisms, and the dawning realization that RNA is the cornerstone of cell biology, development, brain function and probably evolution itself. Key personalities, their hubris as well as prescient predictions are richly illustrated with quotes, archival material, photographs, diagrams and references to bring the people, ideas and discoveries to life, from the conceptual cradles of molecular biology to the current revolution in the understanding of genetic information.Key Features Documents the confused early history of DNA, RNA and proteins - a transformative history of molecular biology like no other. Integrates the influences of biochemistry and genetics on the landscape of molecular biology. Chronicles the important discoveries, preconceptions and misconceptions that retarded or misdirected progress. Highlights major pioneers and contributors to molecular biology, with a focus on RNA and noncoding DNA. Summarizes the mounting evidence for the central roles of non-protein-coding RNA in cell and developmental biology. Provides a thought-provoking retrospective and forward-looking perspective for advanced students and professional researchers. The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.Trade Review“Thrilling and provocative ... There is a need for such a book... There’s nothing quite like this out there.An epic tale of biology’s central molecule, RNA.DNA does only one thing, store information. RNA has a thrilling plethora of functions, including telling DNA what to do. This book takes the reader on an odyssey through the wonders of RNA and its central role in biology.DNA science dominated the second half of the 20th Century, but it’s clear that the 21st Century belongs to RNA. This long-overdue book reveals the diverse wonders of RNA in a series of thrilling and provocative stories.”Tom Cech, Nobel laureate, University of Colorado Boulder_____________________________________“The book is truly monumental and will be treasured by RNA scientists and others, as well. It beautifully captures the excitement and wonder that I have been lucky to experience working in the RNA field since the early 1960s.”Joan Steitz, Yale University_____________________________________“This book is really disruptive and presents a coherent view of our understanding of biology in terms of the genetic molecules, the nucleic acids, DNA and RNA. It covers an immense territory of molecular biology and its history of discoveries, all presented with a clear-cut intellectual thread.... It is very timely by its breadth and emphasis on the role of RNA in biology. It makes a strong case for RNA and its late acceptance... the fight uphill, like that of Sisyphus, was tough and demanded a lot of perseverance. It is really rather complete.”Eric Westhof, University of Strasbourg_____________________________________“The book is unique. It provides the long-overdue correction of the still widespread static views on evolution, development and genome organization and function. It has the potential to induce radical changes in widely held views and attitudes.”Peter Vogt, Scripps Research Institute, La Jolla_____________________________________"History is the key to our modern understanding of RNA. This magnum opus describes how science, scientific thought and landmark discoveries revealed the central role of RNA in molecular biology and evolution. The authors are not only modern pioneers of RNA science, but also the best histo-RNA-ians of our time.”John Rinn, University of Colorado, Boulder_____________________________________"RNA, the Epicenter of Genetic Information is much more than what its title might suggest. This epic book by Mattick and Amaral superbly reflects the continuing excitement about RNA research. It is not only a description of our current understanding of the role of RNA in cell and developmental biology but is also a useful history of molecular biology. Each of the eighteen chapters is a brilliantly written semi-autonomous essay on a particular segment of the RNA odyssey. I wholeheartedly recommend this book to anybody interested in the biology of RNA, in evolution, and in the organization and function of complex genomes." Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Basel_____________________________________"Those who might think that this book is only for the scientists, think again. It is not. It will appeal in equal measure to the thinking generalist and culturally curious interested in the thrilling history of molecular biology, the wonders of the long-overlooked central molecule RNA and its pivotal role in human development and evolution.An epic, provocative, and highly original book that highlights the way science is so often sidetracked by preconceptions and hubris, and explores the struggle to understand all that junk DNA we were told we had. The junk is not junk! The answers are all there. A story and a journey not to be missed!"Gabriel Farago (USA TODAY Bestselling author of the Jack Rogan Mysteries Series) Table of ContentsPreface, Chapter 1. Overview, Chapter 2. The genetic material?, Chapter 3. Halcyon days, Chapter 4. Worlds apart, Chapter 5. Strange genomes, strange genetics, Chapter 6. The Age of Aquarius, Chapter 7. All that junk, Chapter 8. The expanding repertoire of RNA, Chapter 9. Glimpses of a modern RNA world, Chapter 10. Genome sequences and transposable elements, Chapter 11. The human genome, Chapter 12. Small RNAs with mighty functions, Chapter 13. Large RNAs with many functions, Chapter 14. The epigenome, Chapter 15. The programming of development, Chapter 16. RNA and repeats rule, Chapter 17. Plasticity, Chapter 18. Beyond the jungle of dogmas, References

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Book SynopsisGenomes 5 has been completely revised and updated. It is a thoroughly modern textbook about genomes and how they are investigated. As with previous Genomes editions, techniques come first, then genome anatomies, followed by genome function, and finally genome evolution. The genomes of all types of organism are covered: viruses, bacteria, fungi, plants, and animals, including humans and other hominids.Genome sequencing and assembly methods have been thoroughly revised to include new developments in long-read DNA sequencing. Coverage of genome annotation emphasizes genome-wide RNA mapping, with CRISPR-Cas 9 and GWAS methods of determining gene function covered. The knowledge gained from these techniques forms the basis of the chapters that describe the three main types of genomes: eukaryotic, prokaryotic (including eukaryotic organelles), and viral (including mobile genetic elements). Coverage of genome expression and replication is truly genomic, concentrating on the genome-wide implications of DNA packaging, epigenome modifications, DNA-binding proteins, non-coding RNAs, regulatory genome sequences, and protein-protein interactions. Also included are examples of the applications of metabolomics and systems biology. The final chapter is on genome evolution, including the evolution of the epigenome, using genomics to study human evolution, and using population genomics to advance plant breeding. Established methods of molecular biology are included if they are still relevant today and there is always an explanation as to why the method is still important.Genomes 5 is the ideal text for upper-level courses focused on genomes and genomics.Key Features A highly accessible and well-structured book with chapters organized into four parts to aid navigation Superb artwork illustrates the key concepts and mechanisms Each chapter has a set of short-answer questions and in-depth problems to test the readerâs understanding of the material Thoroughly up to date with references to the latest research from the 2020s Trade Review"… a great resource for students wanting to understand genomes and the tremendous advancements in the field …" Ian Gonzales (Yale School of Medicine)"[The book] does exactly what it is supposed to do, describing the current and ever-expanding filed of genomics. I really liked this book and learned so much from reading it thoroughly. It has certainly updated my own knowledge and I would highly recommend it to all, … I am only disappointed I did not have a book as informative as this when I did my undergraduate study many years ago.” Tony Reynolds (The Biologist)Table of ContentsPART 1: HOW GENOMES ARE STUDIED 1. Genomes, Transcriptomes and Proteomes 2. Studying DNA 3. Mapping Genomes 4. Sequencing Genomes 5. Genome Annotation 6. Identifying Gene Functions PART 2: GENOME ANATOMIES 7. Eukaryotic Nuclear Genomes 8. Genomes of Prokaryotes and Eukaryotic Organelles 9. Virus Genomes and Mobile Genetic Elements PART 3: HOW GENOMES ARE EXPRESSED 10. Accessing the Genome 11. The Role of DNA-Protein Interactions in Genome Expression 12. Transcriptomes 13. Proteomes 14. Genome Expression in the Context of Cell and Organism PART 4: HOW GENOMES ARE REPLICATED AND EVOLVE 15. Genome Replication 16. Recombination and Transposition 17. Mutations and DNA Repair 18. How Genomes Evolve

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Book SynopsisMolecular Biology: Structure and Dynamics of Genomes and Proteomes second edition illustrates the essential principles behind the transmission and expression of genetic information at the level of DNA, RNA, and proteins. Emphasis is on the experimental basis of discovery and the most recent advances in the field while presenting a rigorous, yet still concise, summary of the structural mechanisms of molecular biology. Topics new to this edition include the CRISPR-Cas gene editing system, Coronaviruses â structure, genome, vaccine and drug development, and newly recognized mechanisms for transcription termination. The text is written for advanced undergraduate or graduate-level courses in molecular biology.Key Features Highlights the experimental basis of important discoveries in molecular biology Thoroughly updated with new information on gene editing tools, viruses, and transcription mechanisms, termination and antisense Provides learning objectives for each chapter Includes a list of relevant videos from the Internet about the topics covered in the chapter Trade Review"The authors draw a seamless connection between the classical molecular and cell biology techniques and numerous recent advances…[Their] efforts toward inculcating a sense of history in every discovery and concept is nailed in every chapter." - The Yale Journal of Biology and Medicine, December 2016, Volume 89, Issue 4Table of ContentsChapter 1: To the Cell and Beyond: The Realm of Molecular Biology. Chapter 2: From Classical Genetics to Molecular Genetics. Chapter 3: Proteins. Chapter 4: Nucleic Acids. Chapter 5: Recombinant DNA: Principles and Applications. Chapter 6: Protein-Nucleic Acid Interactions. Chapter 7: The Genetic Code, Genes, and Genomes. Chapter 8: Physical Structure of the Genomic Material. Chapter 9: Transcription in Bacteria. Chapter 10: Transcription in Eukaryotes. Chapter 11: Regulation of Transcription in Bacteria. Chapter 12: Regulation of Transcription in Eukaryotes. Chapter 13: Transcription Regulation in the Human Genome. Chapter 14: RNA Processing. Chapter 15: Translation: The Players. Chapter 16: Translation: The Process. Chapter 17: Regulation of Translation. Chapter 18: Protein Processing and Modification. Chapter 19: DNA Replication in Bacteria. Chapter 20: DNA Replication in Eukaryotes. Chapter 21: DNA Recombination. Chapter 22: DNA Repair. Glossary.

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Book SynopsisWritten by world experts in astacology, this book covers a range of aspects of the biology and ecology of freshwater crayfish. With a strong focus on wild crayfish, the book studies the taxonomy and genetics of this interesting group of animals. Under examination also are crayfish growth and reproduction, with detailed illustrations; behavior and chemical ecology of crayfish; diseases of crayfish; holistic understanding of drivers for crayfish population success; and methods for the control of non-native crayfish. Trade ReviewAs indicated in the preface, the editors agree with Thomas Henry Huxley, author of the foundational book The crayfish. An introduction to the Study of Zoology (1880), that "… crayfish are an ideal model organism for study." The editors carry out their intent in ten chapters that cover taxonomy and identification; population genetics; growth and reproduction; behavior; chemical ecology; parasites, commensals, pathogens, and diseases; environmental drivers for population success; field sampling techniques; laboratory methods; and the management of invasive crayfish. Most chapters have multiple authors, the majority of whom are from institutions outside of the United States—this book represents an international endeavor. Each chapter concludes with a helpful overview/summary, followed by many pages of references. The book abounds with diagrams, photos, and tables, all of which are clear and related to the textual material of the chapters. The book includes an adequate index to all chapters. Although the writing style is technical in nature and oriented towards aquatic biologists, hobbyists and field naturalists will find the book useful. Another edited book, published by CRC—Freshwater Crayfish: A Global Overview (2015)—covers many of the same topics as this volume.--L. T. Spencer, Plymouth State University, Appeared in February 2017 issue of CHOICEAs indicated in the preface, the editors agree with Thomas Henry Huxley, author of the foundational book The crayfish. An introduction to the Study of Zoology (1880), that "… crayfish are an ideal model organism for study." The editors carry out their intent in ten chapters that cover taxonomy and identification; population genetics; growth and reproduction; behavior; chemical ecology; parasites, commensals, pathogens, and diseases; environmental drivers for population success; field sampling techniques; laboratory methods; and the management of invasive crayfish. Most chapters have multiple authors, the majority of whom are from institutions outside of the United States—this book represents an international endeavor. Each chapter concludes with a helpful overview/summary, followed by many pages of references. The book abounds with diagrams, photos, and tables, all of which are clear and related to the textual material of the chapters. The book includes an adequate index to all chapters. Although the writing style is technical in nature and oriented towards aquatic biologists, hobbyists and field naturalists will find the book useful. Another edited book, published by CRC—Freshwater Crayfish: A Global Overview (2015)—covers many of the same topics as this volume.--L. T. Spencer, Plymouth State University, Appeared in February 2017 issue of CHOICETable of ContentsTaxonomy and Identification. Population Genetics of Crayfish: Endangered and Invasive Species. Crayfish Growth and Reproduction. Behavior of Freshwater Crayfish. Chemical Ecology of Crayfish. Parasites, Commensals, Pathogens and Diseases of Crayfish. Environmental Drivers for Population Success: Population Biology, Population and Community Dynamics. Sampling Techniques for Crayfish. Laboratory Methods for Crayfish Studies. The Management of Invasive Crayfish.

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Book SynopsisBridging the gap between textbook diagrams and the complex reality of histological preparations, this magnificent atlas of human microanatomy is designed to help students understand the complex structures encountered when viewing microscopic sections of tissues. Instead of simply depicting an individual section, each drawing is a compilation of the key structures and features seen in many preparations from similar tissues or organs. Invaluable to students in a range of life science and medical disciplines including human and veterinary medicine, dentistry, mammalian biology, pharmacy, and nursing.Table of Contents1. Epithelial Tissue.- 2. Connective Tissue.- 3. Cartilage and Bone.- 4. Blood Cells and Hemopoietic Cells.- 5. Muscular Tissue.- 6. Nervous Tissue and Nervous System.- 7. Circulatory System.- 8. Lymphatic Organs.- 9. Respiratory System.- 10. Digestive System.- 11. Urinary System.- 12. Male Reproductive System.- 13. Female Reproductive System.- 14. Endocrine Organs.- 15. The Integument.- 16. The Eye.- 17. The Ear.- References.

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Book SynopsisForty years ago, three medical researchers—Oswald Avery, Colin MacLeod, and Maclyn McCarty—made the discovery that DNA is the genetic material. With this finding was born the modern era of molecular biology and genetics.

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