Biochemistry Books
Springer-Verlag New York Inc. Arachidonic Acid Metabolism and Tumor Promotion
Book SynopsisProstaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from and lipoxygenase pathways, respec arachidonic acid) via the cyclooxygenase tively. Cyclooxygenase products consist of diverse products such as prosta glandin E2 (POE), prostacyclin (POI) and thromboxane A2 (TXA), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy Table of Contents1. Arachidonic Acid Metabolism in the Skin.- 2. Arachidonic Acid Metabolism and Tumor Promotion.- 3. Prostaglandins, Epidermal Hyperplasia and Skin Tumor Promotion.- 4. Effects of Phorbol Esters on Phospholipid Metabolism in Vitro.- 5. Tumor Promoting Phorbol Esters May Affect Cell Membrane Signal Transmission by Protein Kinase.- 6. Active Oxygen and Promotion.- 7. Possible Involvement of Arachidonate Products in Tumor Promoter Inhibition of Cell-Cell Communication.- 8. Proteases and Cyclic Nucleotides.- Perspectives.
£999.99
Apple Academic Press Inc. Environmental Problems in Marine Biology
Book SynopsisMarine environment can be affected by several pollutants such as the presence of elements and their chemical species, pharmaceuticals, nanoparticles and other emerging contaminants. Environmental monitoring can be assessed by genomics, proteomics (i.e. redox proteomics), chemical speciation analysis and metallomics, metabolomics as well as other advanced strategies. The present book is a useful methodological tool for researchers and specialists in the field of analytical chemistry, environmental sciences, biochemistry, genomics and toxicology. The book includes for the first time the methodological aspects and applications related to chemical speciation and omics strategies applied to marine environment. Table of ContentsElement Speciation in Seawater: From Free Metal Determination to Proteomic Analysis. The Decisive Role of ICPMS and Related Hyphenated Techniques in Multielement and Speciation Analysis of Marine Biota. Mercury Speciation in Marine Biota and its Influence on Human Health: Metallomic and Metabolomic Approaches. Selenium Speciation in the Marine Environment. Arsenic Occurrence in Marine Biota: The Analytical Approach. Biological Effects of Organotins on the Marine Environment. Functional Genomics Approaches in Marine Pollution and Aquaculture. New Trends in Aquatic Pollution Monitoring: From Conventional Biomarkers to Environmental Proteomics. Protein Expression Profiles in Marine Organisms Exposed to Nanoparticles. Effects of Climate Change in Marine Organisms: A Proteomic Approach. Environmental Metabolomics and Toxicometabolomics in Marine Pollution Assessment. Fate and Toxicity of Inorganic Engineered Nanomaterials in the Marine Environment: Analytical Techniques and Methods. Pharmaceuticals in the Marine Environment: Analytical Techniques and Applications. Biological Effects of Pharmaceuticals on the Marine Environment.
£171.00
Taylor & Francis Inc Introduction to Proteins
Book SynopsisIntroduction to Proteins provides a comprehensive and state-of-the-art introduction to the structure, function, and motion of proteins for students, faculty, and researchers at all levels. The book covers proteins and enzymes across a wide range of contexts and applications, including medical disorders, drugs, toxins, chemical warfare, and animal behavior. Each chapter includes a Summary, Exercises, and References.New features in the thoroughly-updated second edition include: A brand-new chapter on enzymatic catalysis, describing enzyme biochemistry, classification, kinetics, thermodynamics, mechanisms, and applications in medicine and other industries. These are accompanied by multiple animations of biochemical reactions and mechanisms, accessible via embedded QR codes (which can be viewed by smartphones) An in-depth discussion of G-protein-coupled receptors (GPCRs) A wider-scale description of Trade Review"This is the most interesting to read and complete text I have found for senior undergraduate or early graduate-level coverage of protein structure and function, and a great reference book to have on hand. This text is significantly updated and printed in a hardcover format with easy-to-read text (larger font and pages than usual, with margins for note-taking) and comes with annotatable ebook access for free. Overall, this is a significantly enriched 2nd edition of a book we have used successfully for several years now, which I enthusiastically recommend!" --Leslie Kuhn, Departments of Biochemistry & Molecular Biology and Computer Science & Engineering, Michigan State University, USA "I used this book when studying for a course on the Mechanisms of Enzyme Catalysis. The book made everything I was struggling with so clear! It is extremely well organized and very, very thorough which makes studying from it easy! 10/10 would recommend to anyone studying proteins and/or enzymes, or even someone who just wants to learn more. Anyone looking for a supplementary reading for your course should have this text book - even if you think you don't need it, trust me, you do." --Customer review on Amazon.com Praise for the First edition: "This book offers a unique combination of structure, thermodynamics and biology. I was impressed both by the breadth of the topics covered and by the depth in which they are treated. General principles are made intuitively clear based on well-chosen examples, many of them having relevance to disease. The book could fit well as a textbook in structural biology and molecular biophysics courses." --Barry Honig, Columbia University, New York, New York, USA "I’ve just lately used this textbook for a presentation on electrostatics. Although I have an organic background, I discovered that the explanations of electrostatic interactions are very clear and informative. The language isn’t too technical and may be easily understood by biology students. The textbook covers numerous examples and colorful illustrations, which made it easy to understand the principles discussed. The book is well organized in chapters for all the fundamental topics. I feel this book would be appropriate for any undergraduate and graduate scholar who’s keen on proteins. … It’s complete, easy to observe and (something I at least discover uncommon for textbooks) pleasing to read. The authors don’t shrink back from any subjects, but clarify things in a straightforward method supported by ample examples. Highly recommended." --Physics Book Reviews at dowdawgs.com, May 2013 "Introduction to Proteins is an excellent, state-of-the-art choice for students, faculty, or researchers needing a monograph on protein structure. …The book is clear, well organized, aptly illustrated in color, and a pleasure to read. The first two chapters are an impressive textbook unto themselves … The book is thoroughly documented with citations to the literature gathered at the end of each chapter. … Overall, this is an immensely informative, thoroughly researched, up-to-date text, with broad coverage and remarkable depth. Introduction to Proteins would provide an excellent basis for an upper level or graduate course on protein structure, and a valuable addition to the libraries of professionals interested in this centrally important field." --Eric Martz, Biochemistry and Molecular Biology Education, Vol. 40, 2012 "This is an important book. It captures in a very accessible way a growing body of literature on the structure, function and motion of proteins, and links this to more established paradigms such as a reader might find in a mainstream biochemistry text. The text is littered with excellent examples of the wider relevance of the material covered. The book is also exceptionally well written. I learned new things from each chapter. Overall, a superb publication that would be very useful to undergraduates, graduate students, postdoctoral researchers and instructors involved in structural biology or biophysics courses or in research on protein structure–function relationships. I would recommend it highly." --David Sheehan, ChemBioChem, 2011 "The book provides general guidelines for understanding protein structure and demonstrates how we can use the structure to phrase testable hypotheses about biological function. The repeated use of the same example makes it easier for the reader to grasp the general principles. The book gives a coherent picture of each topic and includes ample references, making it possible for the interested reader to dig deeply into various topics. The book also covers structural aspects of intrinsically unstructured proteins and how this property facilitates their biological function. It provides background in cell biology, basic chemistry and thermodynamics, making it useful for newcomers to the protein structure field who want to catch up quickly. It is also easy for experts to dive into the more specialized aspects quickly. The book provides references to user-friendly web tools in the field. The publisher’s website provides exercises on both theory and practice. Sample solutions and PowerPoint presentations are available for qualified teachers. These make the book attractive as the main textbook in an undergraduate course on protein structure, for parts of freshman biochemistry, and as a supplement for many undergraduate and graduate courses." --Burkhard Rost, Technische Universität München, Germany Table of ContentsIntroduction. Protein Structure. Methods of Structure Determination and Prediction. Energetics and Protein Stability. Protein Dynamics. Intrinsically Unstructured Proteins. Membrane-Bound Proteins. Protein-Ligand Interactions. Enzymatic Catalysis
£80.74
Nova Science Publishers Inc Trehalose: Sources, Chemistry and Applications
Book Synopsis
£76.49
Cold Spring Harbor Laboratory Press,U.S. Cell-Cell Junctions, Second Edition
Book Synopsis
£999.99
Basic Health Publications NADH: The Biological Hydrogen: The Secret of Our
Book SynopsisThe most promising natural substance in our body is NADH, the biological form of hydrogen. It reacts with the oxygen present in every living cell, producing energy and water. The more energy it can produce the better it function, and the longer the cell, and the entire organism, lives. This book describes the many positive benefits of this new energy supplement that is a potent antioxident, lowers cholesterol and high blood pressure, and boosts the immune system.
£19.04
Apple Academic Press Inc. Clinical Biochemistry and Drug Development: From
Book SynopsisThis new volume focuses on clinical biochemistry fundamentals, cell culture techniques, and drug discovery and development concepts. It deals with three different fields of clinical research: cell culture, clinical biochemistry, and drug discovery and development.The book introduces cell animal and bacterial culture techniques and their potential uses as well as cell culture techniques. The biochemistry aspect of the book covers the principles of clinical biochemistry and biochemical analysis, biochemical aids to clinical diagnosis, measurement, and quality control. The book also presents important concepts in cell membrane receptor signal transduction pathways as drug targets.The drug development focus of the book discusses the fundamentals of human disease and drug discovery. Various in silico, in vitro, and in vivo approaches for drug discovery are examined, along with a discussion on drug delivery carriers and clinical trials. Overall, the volume provides an overview of the journey from clinical fundamentals to clinical output.Table of Contents1. An Introduction to Cell Culture 2. Animal Cell Culture 3. Bacterial Cell Culture 4. Potential Use of Cell Cultures 5. Principles of Clinical Biochemistry and Biochemical Analysis 6. Biochemical Aids to Clinical Diagnosis 7. Clinical Measurements and Quality Control 8. Cell Membrane Receptor 9. Mechanisms of Signal Transduction 10. Human Disease Drug Therapy and Drug Discovery 11. Drug Development: In Silico, In Vivo and System Biology Approach 12. Drug Development: Drug Delivery Carriers and Clinical Trial 13. Role of Micro RNA in Prostate Cancer Therapy 14. Pathogenesis, Molecular Mechanisms of Progression, and Therapeutic Targets of Liver Fibrosis: An Update 15. Prostate Cancer: Molecular Aspects, Biomarkers, and Chemo-Preventive Agents 16. Overview of Tuberculosis Biomarkers: An Update
£78.84
Royal Society of Chemistry Drug Discovery for Leishmaniasis
Book SynopsisFor human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance to current treatments. Chemotherapy remains the only treatment option for the bulk of patients. However, this is largely unaffordable for most. In the past three years numerous advances in drug discovery have been made for treating this disease by exploiting diverging metabolic pathways between the Leishmania enzymes and their hosts, using nanotechnology to target the immune cell phagolysosomes where Leishmania resides. Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in Leishmania. Recent studies have shown that leishmaniasis affects some of the poorest people in the world, with 95% of fatal cases occurring in only 6 countries. With the WHO goal of eliminating this public health problem in the South-east Asia Region by 2020, this book will be important for anyone who is interested in neglected tropical diseases.Trade ReviewThis is a timely and highly relevant book that provides a comprehensive and in-depth overview of the current state and future directions of drug discovery for leishmaniasis. It has a broad scientific scope and wonderful insights from leading experts in the field which ensures that there is something for everyone, and that this book is truly a must-have for anyone working in the area of leishmaniasis. -- Dr. Steven L. Cobb, Durham University (UK) * ChemMedChem, DOI: 10.1002/cmdc.201800266 *Table of ContentsLeishmaniasis, Impact and Therapeutic Needs; Anti-leishmanial Drug Discovery: Past, Present and Future Perspectives; From Bench to Bedside: Development and Optimization of Clinical Therapies for Visceral Leishmaniasis; Drug Assay Methodology in Leishmaniasis: From the Microplate to Image Analysis; The Pursuit of Novel Anti-leishmanial Agents by High-throughput Screening (HTS) of Chemical Libraries; Omics and Their Impact on the Development of Chemotherapy Against Leishmania; In silico Tools for Target Identification and Drug Molecular Docking in Leishmania; Medicinal Chemistry Strategies to Discover New Leishmanicidal Drugs; Natural Products as a Source of New Drugs Against Leishmania; Organometallic Compounds in Chemotherapy Against Leishmania; New Avenues for Drug Delivery in Leishmania: Using Treatment of Visceral Leishmaniasis with Amphotericin B as an Exemplar; Addressing the Molecular Biology of Leishmania for Drug Development; The Physical Matrix of the Plasma Membrane as a Target: The Charm of Drugs with Low Specificity; Nutrient Transport and Sensing as Pharmacological Targets for Leishmaniasis; Carbon Metabolism as a Drug Target in Leishmania; The Redox Metabolism and Oxidative Stress in Leishmania as a Crossroads for the Lethal Effect of Drugs; DNA Topoisomerases as Promising Targets for Leishmania Chemotherapy; Molecular Basis of Drug Resistance in Leishmania; The Macrophage–Parasite Interface as a Chemotherapeutic Target in Leishmaniasis
£141.55
Royal Society of Chemistry RNA Polymerases as Molecular Motors: On the Road
Book SynopsisTo thrive, every living cell must continuously gauge and respond to changes in its environment. These changes are ultimately implemented by modulating gene expression, a process that relies on transcription by Nature’s most multivalent molecular machine, the RNA polymerase. This book covers progress made over the past decade understanding how this machine functions to compute the cellular state, from the atomistic structural level responsible for chemistry to the integrative level at which RNA polymerase interacts with the other key molecular machineries of the cell.Table of ContentsThe Transition from Transcription Initiation to Transcription Elongation: Start Site Selection, Initial Transcription, and Promoter Escape; Molecular Basis for Transcriptional Fidelity Control by RNA Polymerase II; 1RNA Polymerase as a Torsional Motor; RNA Polymerase-associated Transcription Elongation Factors; Rho Termination Factor: One Ring to Bind Them All; Global Regulation of Transcription by Nucleotides and (p)ppGpp; Helicases and the Obstructive RNAP; Transcription/Replication Conflicts, Resolution and Coregulation; Using Single-cell RNA Measurements to Decipher the Stochastic Kinetics of Transcription; Molecular Dynamics Simulations and Kinetic Network Models Elucidate RNA Polymerase Transcription Elongation Mechanisms
£999.99
Royal Society of Chemistry Conference on Drug Design and Discovery
Book SynopsisThis publication is based on peer-reviewed manuscripts from the 2019 Conference on Drug Design & Discovery Technologies (CDDT) held at Ramaiah University of Applied Sciences, India. Providing a wide range of up to date topics on the latest advancements in drug design and discovery technologies, this book ensures the reader receives a good understanding of the scope of the field. Aimed at scientists, students, regulators, academics and consultants throughout the world, this book is an ideal resource for anyone interested in the state of the art in drug design and discovery.Table of ContentsPart 1: Structure Based Drug Design Approach; MOLECULAR DYNAMICS SIMULATIONS ON BACILLUS SUBTILIS EngA – FOR EXPLORING NUCLEOTIDE DEPENDENT CONFORMATIONS; ERRORS MADE IN AB INITIO+ HOMOLOGY-BASED PROTEIN STRUCTURE PREDICTION TOOLS ARISE DUE TO LACK OF CONSIDERATION OF IMPACT FORCES; PARADIGM SHIFT IN RESEARCH FOCUS: COMPUTATIONAL SOFTWARES IN CANCER BIOLOGY; VIRTUAL SCREENING OF BIO-ACTIVE COMPOUNDS AS AN INHIBITOR OF C-FLIP PROTEIN FOR CANCER TREATMENT; FRAGMENT-BASED DESIGN OF NOVEL INHIBITORS OF HPV 16 E6 ONCOPROTEIN: MOLECULAR DOCKING, MOLECULAR DYNAMICS SIMULATION AND IN SILICO ADME ANALYSIS; DESIGN AND SYNTHESIS OF NOVEL POLY ADP-RIBOSE POLYMERASE 1 (PARP1) INHIBITORS FOR THE TREATMENT OF SOLID TUMORS; IN SILICO EVALUATION OF THE ROLE OF PHYTOCHEMICALS IN ALZHEIMER’S DISEASE THROUGH WNT SIGNALING MODULATION; IDENTIFICATION OF POTENTIAL VEGFR2 INHIBITORS EMPLOYING E-PHARMACOPHORE MODEL, VIRTUAL SCREENING, MOLECULAR DYNAMIC SIMULATION AND ADME ANALYSIS; DEVELOPMENT OF NEW NEPRILYSIN INHIBITOR AS A MODULATOR OF CHRONIC KIDNEY AND HEART DISEASE USING IN SILICO DRUG REPURPOSING APPROACH; ANTICANCER POTENTIAL OF PHYTOCONSTITUENTS MODULATING NA/ K ATPASE PUMP; A NOVEL REPURPOSING STRATEGY; IN SILICO HIT IDENTIFICATION, DRUG REPURPOSING, PHARMACOKINETIC AND TOXICITY PREDICTION OF c-MET KINASE INHIBITORS FOR CANCER THERAPY; DESIGN OF POTENT TELOMERASE INHIBITORS USING STRUCTURE BASED APPROACHES; MOLECULAR DOCKING BASED SCREENING OF “NITROGEN CONTAINING BISPHOSPHONATE CONJUGATE WITH HYDROXYAPETITE” ACTIVE CONSTITUENTS TOWARDS MELVONATE PATHWAY IN FINDING POTENT INHIBITORS FOR ANTI-OSTEOPOROTIC ACTIVITY; ZANAPEZIL, A POTENTIAL REPURPOSABLE DRUG AGAINST HUNTINGTON DISEASE: AN IN SILICO FORECAST; DRUG REPURPOSING FOR HEPATOCELLULAR CARCINOMA VIA VIRTUAL SCREENING INTEGRATED WITH BIOINFORMATICS ANALYSIS; AN IN SILICO TARGET SPECIFIC DRUG REPURPOSING APPROACH FOR MULTIPLE SCLEROSIS; Part 2: Structure Based Drug Design and Biological Evaluation; DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF 3-PHENYLISOXAZOLO[5,4-D]PYRIMIDINE DERIVATIVES AS ANTICANCER AGENTS.; QSAR AND DOCKING STUDIES ON TRIAZOLE BENZENE SULFONAMIDES WITH HUMAN CARBONIC ANHYDRASE IX INHIBITORY ACTIVITY; DESIGN AND SYNTHESIS OF SOME NOVEL ERLOTINIB DERIVATIVES AS POTENTIAL EGFR KINASE INHIBITORS; DESIGN, SYNTHESIS AND CHARACTERIZATION OF NOVEL SERIES OF 1,3-THIAZOLE CONTAINING HETEROCYCLES AS INHIBITORS OF DHFR FOR USE AS ANTICANCER AGENTS; IN SILICO AND IN VITRO STUDIES OF BENZOHYDRAZIDE ANALOGUES AS POTENT ANDROGEN RECEPTOR ANTAGONIST; DESIGN, MOLECULAR DOCKING, SYNTHESIS AND ANTI-FUNGAL ACTIVITY OF NOVEL BENZIMIDAZOLE DERIVATIVES; SYNTHESIS, ANTIOXIDANT ACTIVITY AND COMPUTATIONAL STUDIES OF 2-SUBSTITUTED-L-THIAPROLINES; DESIGN, SYNTHESIS, CHARACTERISATION AND ANTIFUNGAL ACTIVITY OF NOVEL PYRIMIDONE DERIVATIVES; Part 4: Chemical Synthesis and Biological Evaluation; MICROWAVE-ASSISTED SYNTHESIS OF 4-BENZYLIDENE-2-(2-FLUOROPHENYL) OXAZOL-5(4H)-ONE DERIVATIVES CATALYSED BY EGG SHELL POWDER AND EVALUATION OF THEIR ANTI-MICROBIAL ACTIVITY; SYNTHESIS OF OXAZOLOQUINOLONE DERIVATIVES AND EVALUATION OF THEIR POTENCY TO REACTIVATE RAT BRAIN ACETYLCHOLINESTERASE INHIBITED BY CHLORPYRIFOS; Part 5:
£118.75
Royal Society of Chemistry Bird and Reptile Species in Environmental Risk
Book SynopsisWith the expansion of human settlements and the environmental changes brought on by human activity and pollutants, toxicology and risk assessment of bird and reptile species is becoming increasingly of interest to toxicologists involved in environmental research. This book focuses specifically on environmental risk assessment in non-conventional bird and reptile species. Bird and Reptile Species in Environmental Risk Assessment Strategies will be an ideal companion to toxicologists and ecologists interested in risk assessment in the environments of birds and reptiles, particularly those with an interest in the impact introduced by human activity. The book will also be of interest to those working in conservation biology, biological invasion, biocontrol and habitat management.Table of ContentsGeneral Aspects – Current and Further Perspectives; Development of Aquatic Bird Indicators of Sublethal Mercury Exposure and Risk in Wild Populations of Water Birds in the Everglades;The Importance of Ecological Traits in Assessing Seabird Vulnerability to Environmental Risks;A Review on Levels and Distribution Pattern of Organochlorine Pesticides in Eggs of Wild Birds in India;Impacts of Agricultural Intensification on Farmland Birds and Risk Assessment of Pesticide Seed Treatments;Teratological Effects of Pesticides in Reptiles - A Review;Combined Impact of Pesticides and other Environmental Stressors on Reptile Diversity in Irrigation Poinds Compared to other Animal Taxa;Current Progress in Developing Standardized Methods for Reptilian Toxicity Testing to Inform Ecological Risk Assessment;Morphological and Molecular Evidence of Active Principle Glyphosphate Toxicity on the Liver of the Field Lizard Podarcis siculus;What is Caiman latirostris teaching us about Endocrine Disruptors;The Broad Snouted Caiman (Caiman latirostris): A Model Species for Environmental Pesticide Contamination Assessment through Molecular Markers; Epilogue and Final Remarks
£999.99
Royal Society of Chemistry Turn On and Tune In: Psychedelics, Narcotics and
Book SynopsisTimothy Leary's advice to "tune in, turn on and drop out" was a 1960s exhortation to experiment with LSD, but humans had been consuming ergot alkaloids related to lysergic acid diethylamide for at least a thousand years. Opium has been around even longer with its medicinal uses being known to the Ancient Sumerians as long ago as 3400 BC. This is the first book to cover all of the major psychoactive drugs (both natural and synthetic) in one volume, and the only one to cover all aspects of these drugs from their anthropological and sociological influences through to their chemistry and pharmacology. It covers a range of substances including LSD, opium, heroin, cocaine, cannabis, peyote, belladonna, mandrake, and absinthe. The book is highly readable and concentrates on the characters (e.g. authors, painters, pop stars, hippies, politicians and drug barons), both famous and infamous, who have ensured that psychoactive drugs hold an enduring fascination and interest for everyone. The basic chemistry and pharmacological activity covered together with a brief account of useful drugs that have emerged from a study of the psychoactive ones.Trade Review"This fascinating book...introduces us to the history of the various groups of mind-altering chemicals, beginning with ergot and LSD.""The book is beautifully produced and well illustrated.""...would make excellent background reading for pharmacy students." * The Pharmaceutical Journal, April 2010 *Table of ContentsChapter 1: From Ergotism to LSD; Chapter 2: From Opium to Heroin; Chapter 3: Coca and Cocaine; Chapter 4: Cannabis: Hashish, Marijuana, Chaeas and Bhang; Chapter 5: Belladonna, Mandrake and Daturas; Chapter 6: Peyote and Amphetamines; Chapter 7: Fly Agaric; Chapter 8: Absinthe
£23.70
Royal Society of Chemistry Emerging Drugs and Targets for Alzheimer's
Book SynopsisAlzheimer's disease is the most prevalent neurodegenerative disorder in the elderly. A recent study from the Bloomberg School of Public Health recently estimated that over 26 million people were living with the disease in 2006 and that the global prevalence of the disease will grow to 106 million by 2050. By that time, 43 per cent of those living with the disease will need high-level care, equivalent to that of a nursing home. However, even if modest advances in preventing or delaying the disease's progression were made, it could have a huge impact on global public health. According to this study, interventions that could delay the onset of the disease by as little as one year would reduce the prevalence of the disease by 12 million fewer cases in 2050. These figures reinforce how important it is to find an effective intervention for Alzheimer's disease. Emerging Drugs and Targets for Alzheimer's Disease collects some of the most outstanding examples of new drugs currently under pharmaceutical development or new targets in the validation process that will reach the Alzheimer's drug market over the next few years as disease modifying drugs. Written by a team of distinguished experts, these volumes are an essential resource for scientists in the pharmaceutical and biotechnology industries and academics working in the neurosciences field.Table of ContentsBeta-Amyloid as target; Chapter 1: The amyloid hypothesis of AD and prospects for therapeutics; Chapter 2: Targeting Alzheimer's ?-Secretase: Genetic and Chemical Modulation; Chapter 3: Cholesterol and AD: the molecules, the targets; Chapter 4: The Bimodal Features of Butyrylcholinesterase in Cholinergic Neurotransmission and Amyloid Suppression; Chapter 5: Scyllo-inositol, a potential therapy for Alzheimer's disease; Chapter 6: Immunotherapeutic strategies toward treatment of AD; Tau protein as target; Chapter 7: Alzheimer Neurofibrillary Degeneration: Pivotal Role and Therapeutic Targets; Chapter 8: Multiple roles of glycogen synthase kinase-3 in AD; Chapter 9: Tau protein kinases inhibitors: from the bench to the clinical trials; Chapter 10: Activating PP2A as a therapeutic intervention strategy in AD; Chapter 11: Rationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies; Glucose Metabolism as target; Chapter 12: Insulin Insulin Resistance and neurodegeneration: Type 2 versus type 3 diabetes mellitus; Chapter 13: Insulin-like Growth Factor I as a disease-modifying therapy in Alzheimer¦s disease; Chapter 14: Ketone bodies as a therapeutic for Alzheimer¦s disease
£137.75
Royal Society of Chemistry Extracellular and Intracellular Signaling
a huge range and FREE tracked UK delivery on ALL orders.
£126.34
Royal Society of Chemistry Stability of Complex Carbohydrate Structures: Biofuels, Foods, Vaccines and Shipwrecks
Book SynopsisComplex carbohydrates such as high molecular weight polysaccharides like starch and cellulose, are well known for their importance in foodstuffs, paper and wood, but their importance extends far beyond that into the biopharmaceutical, healthcare, oil and printing industries. This book, based on a discussion meeting organised by RSC Biotechnology and Carbohydrate Groups, brings together leading experts from the polysaccharide and glycoconjugate communities to review, discuss and assess in detail one specific topic, namely the importance of the stability and degradation of carbohydrate structures. Coverage includes applications as diverse as food, biopharmaceuticals, vaccines, biofuels and preservation of Viking boats. Providing essential reading for anyone interested in these structures and the diversity of their applications, it will appeal to a broad, multidisciplinary group from industry, academia and research institutions.Table of ContentsCarbohydrates: First cousins of Water; Enzymic degradation of cell wall polysaccharides; Dietary Fibre: Functional Components and Mechanisms of Action in the Gastrointestinal Tract; Enzymatic treatment of polysaccharides; Stability of polysaccharide encapsulates; Polysaccharide and glycoconjugate vaccines; Mucin turnover; Some advances in hydrodynamic stability probes; Stability of chitosan and pectin as nasal and intestinal mucoadhesives; Cellulose crystallinity: perspectives from spectroscopy and diffraction; Cellulose; Cellulose de-construction: what can be learned from molecular modeling and dissolution experiments?; Lignin; Observations on bacterial degradation of historical wood timbers found in near anaerobic waterlogged environments; Subject Index
£113.95
Royal Society of Chemistry Mechanisms and Metal Involvement in
Book SynopsisDementia and neurodegenerative diseases such as Parkinson’s and Alzheimer’s are becoming an increasingly important cause of medical and social concern due to the growth in the ageing population. Mechanisms and Metal Involvement in Neurodegenerative Diseases delivers in one volume a streamlined source of information on each of the main neurodegenerative diseases including mild cognitive impairment, Parkinson's, Alzheimer's, Freiderich's ataxia, prion disease, multiple sclerosis and alcoholic brain damage. Each chapter is structured to give the definition of disease, proteins involved with structure of normal protein and abnormal proteins, pathology associated with the abnormal proteins, oxidative stress and inflammation, iron homeostatic mechanisms, primary neurotransmitter involved, other metal involvement and therapeutic strategies. Structures of the adherent protein involved in the disease process are also presented with emphasis on the chemical structures used in the treatment of each neurodegenerative disease together with their biochemical mode of action. Written by acknowledged experts in their respective areas this new book provides readers with readily accessible information on each of the neurodegenerative diseases.Table of ContentsIntroduction; Mild cognitive impairment; Parkinson's Disease; Alzheimer's Disease; Freiderich's Ataxia; Prion Disese; Multiple Sclerosis; Alcoholic brain damage;
£132.99
Caister Academic Press Real-time PCR in Microbiology: From Diagnosis to
Book Synopsis
£208.05
Cold Spring Harbor Laboratory Press,U.S. Signaling by Receptor Tyrosine Kinases
Book Synopsis
£999.99
Springer Nature Switzerland AG Critical Dietetics and Critical Nutrition Studies
Book SynopsisThis second volume in the Food Policy series focuses on critical nutrition and dietetics studies, offering an innovative and interdisciplinary exploration of the complexities of the food supply and the actors in it through a new critical lens. The volume provides an overview of the growth of critical nutrition and dietetics since its inception in 2009, as well as commentary on its continuing relevance and its applicability in the fields of dietetic education, research, and practice. Chapters address key topics such as how to bring critical dietetics into conventional practice, applying critical diets in clinical practice, policy applications, and new perspectives on training and educating a critical nutrition and dietetic workforce. Contributing authors from around the globe also discuss the role of critical nutrition dietetics in industry, private practice, and consultancy, as well the role of critical dietetics in addressing the food, hunger, and health issues associated with the world economic crisis. The authors designed the volume to be a reference work for students enrolled in undergraduate and postgraduate courses in Critical Nutrition, Critical Food Studies, and Critical Dietetics. Each chapter offers concise aims and learning outcomes, as well as assignments for students and a concise chapter summary. These features enhance the value of the volume as a learning tool. Table of ContentsForeword by John Coveney and Martin CaraherChapter 1: Foundations of critical aspects of food and nutrition studiesJacqui GingrasChapter 2: Critical perspectives in clinical practice of nutrition and dieteticsDebbie MacLellanChapter 3: Community nutrition and dietetics practices and food democracySue BoothChapter 4: Policy and practice: what does this gap look like using a critical nutrition and dietetics lens?Yuka AsadaChapter 5: Training and educating a critical nutrition and dietetic workforce: new perspectivesDaphne LordlyChapter 6: Why is a critically reflexive practice critical to nutrition and dietetics?Angela CuddyChapter 7: Swimming against the tide: 12 ways of bringing critical nutrition and dietetics into conventional practicesCathy MorleyChapter 8: Critical nutrition and dietetics in industry, private practice and consultancy: the importance of ethicsJohn CoveneyChapter 9: World economic crisis: food, hunger and health disparitiesJill WhiteChapter 10: Dietitian as Advocate and Activist: Our Past, Present, and Future PossibilitiesJennifer BradleyChapter 11: Toward critical nutrition counselling practice and pedagogyIan WisemanSummary: Summing it all up criticallyJohn Coveney and Martin Caraher
£58.49
Springer Nature Switzerland AG Strigolactones - Biology and Applications
Book SynopsisThis book describes the exciting biology and chemistry of strigolactones. Outgrowth of shoot branches? Development of lateral roots? Interactions with beneficial microorganisms? Avoiding parasitic plants? Responding to drought conditions? These important “decisions” that plants make are all regulated by a group of hormones called strigolactones.The latest research has yielded a number of new biological concepts, such as a redefinition of plant hormones and their crosstalk, new functional diversity of receptors, hormonal “smoke and mirrors,” core signaling pathways, and even phloem transport of receptor proteins. Another important aspect of strigolactones is the related synthetic chemistry, which could pave the way for a variety of potential applications in agriculture and medicine.The book explains in detail the role that strigolactones play in plant development, and addresses the interaction of plants with soil biota and abiotic stress conditions, prospects of strigolactone biochemistry and evolution, and chemical synthesis of natural strigolactones and analogs, together with their potential applications. Including a glossary and end-of-chapter synopses to aid in comprehension, it offers a valuable asset for teachers, lecturers and (post-) graduate students in biology, agronomy and related areas..Table of Contents1. Strigolactone natural biosynthesis.- 2. Strigolactones as plant hormones.- 3. Strigolactones and parasitic plants.- 4. Strigolactones and the soil microbiota.- 5. Strigolactones likes and evolution.- 6. Strigolactones synthetic chemistry and applications.- 7. Synopses.
£40.49
Springer Nature Switzerland AG The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation
a huge range and FREE tracked UK delivery on ALL orders.
£79.20
Springer International Publishing AG Nuclear Receptors in Human Health and Disease
a huge range and FREE tracked UK delivery on ALL orders.
£999.99
Springer International Publishing AG Understanding Kinetic Resolution by Hydrolases: Maximizing Enantioselectivity
Book SynopsisThis brief is a concise guide that explores the theory and practical aspects of improving enantioselectivity in enzymatic kinetic resolution, with a specific focus on the role of hydrolases in this process. Enzymatic kinetic resolution is a valuable technique for obtaining enantiopure compounds, and hydrolases are highlighted as a crucial class of enzymes widely used in industries for chiral synthesis involving kinetic resolution. The book emphasizes the importance of tuning and optimizing the enzymatic kinetic resolution process to achieve the highest possible enantiomeric excess in the final product or starting material while maintaining the desired yield. Through illustrative examples, the text aims to make the concept accessible and appealing to graduate students, researchers, and young organic chemists seeking to incorporate hydrolases in their stereoselective synthesis endeavors.Table of ContentsUnderstanding Enzymatic Kinetic Resolution.- Essential Parameters: Determination and Significance - Enantioselectivity: The Decisive Factors.- Dynamic Kinetic Resolution.
£999.99
De Gruyter Chemistry of Nucleic Acids
Book SynopsisLife in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses the main aspects of synthesis, hydrolytic stability, solution equilibria of nucleosides and nucleotides as well as base modifications of nucleic acids. The author further describes their structural analogues used as therapeutic drugs, such as antivirals and anticancer agents, and prodrug strategies of nucleotides.
£59.25
Springer International Publishing AG Advanced Technologies for Protein Complex
Book SynopsisThis book presents advanced expression technologies for the production of protein complexes. Since complexes lie at the heart of modern biology, the expression, purification, and characterization of large amounts of high-quality protein complexes is crucial for the fields of biomedicine, biotechnology, and structural biology. From co-expression in E. coli, yeast, mammalian and insect cells to complex reconstitution from individual subunits, this book offers useful insights and guidance for successful protein expressionists. Across several sections readers will discover existing opportunities for the production of protein complexes in bacterial systems (including membrane proteins and cell-free co-expression), methylotrophic and non-methylotrophic yeasts, protozoa (Leishmania terantolae and Dictyostelium discoideum), baculovirus-infected insect cells, mammalian cells, plants and algae. Complex reconstitution from individually purified subunits or subcomplexes is discussed as a complementary strategy. A last section introduces briefly some of the biophysical and structural characterization techniques for macromolecular complexes using state-of-the-art solution scattering and nuclear magnetic resonance. This work is a guided tour over some of the most powerful and successful protein expression technologies, with a focus on co-expression and high-throughput applications. It is addressed to everyone interested in the production and characterization of macromolecular complexes, from university students who want an accessible description of the major co-expression systems to researchers in biomedicine and the life sciences seeking for an up-to-date survey of available technologies.Table of ContentsPreface. Complex Biologics: Engineering the Tools and the Hosts. M. Cristina Vega, Francisco J. Fernández and Imre Berger Section 1: Introduction 1. Protein complex production from the drug discovery standpoint; Ismail Moarefi <2. Choose a suitable expression host: a survey of available protein production platforms; Francisco J. Fernández and M. Cristina Vega Section 2: Prokaryotic expression hosts 3. ACEMBL Tool-Kits for High-Throughput Multigene Delivery and Expression in Prokaryotic and Eukaryotic Hosts; Yan Nie, Maxime Chaillet, Christian Becke, Matthias Haffke, Martin Pelosse, Daniel Fitzgerald, Ian Collinson, Christiane Schaffitzel and Imre Berger 4. Complex reconstitution and characterization by combining co-expression techniques in Escherichia coli with high-throughput; Renaud Vincentelli and Christoph Romier 5. Membrane protein production in E. coli for applications in drug discovery; Harm Jan (Arjan) Snijder and Jonna Hakulinen6. Cell-free Synthesis of Macromolecular Complexes; Matthieu Botte, Aurélien Deniaud and Christiane Schaffitzel 7. A Bacillus megaterium system for the production of recombinant proteins and protein complexes; Rebekka Biedendieck 8. Protein complex production in alternative prokaryotic hosts; Sara Gómez, Miguel López-Estepa, Francisco J. Fernández and M. Cristina Vega Section 3: Lower Eukaryotic expression hosts 9. Production of Protein Complexes in Non-methylotrophic and Methylotrophic Yeasts; Francisco J. Fernandez, Miguel López-Estepa, Javier Querol-García and M. Cristina Vega 10. Leishmania tarentolae for the Production of Multi-Subunit Complexes; Tomoaki Niimi 11. Alternative Eukaryotic Expression Systems for the Production of Proteins and Protein Complexes; Sara Gómez, Miguel López-Estepa, Francisco J. Fernández, Teresa Suárez and M. Cristina Vega Section 4: Higher Eukaryotic expression hosts 12. Fundamentals of baculovirus expression and applications; Tom A. Kost and Christopher W. Kemp 13. The MultiBac Baculovirus / Insect Cell Expression Vector System for Producing Complex Protein Biologics; Duygu Sari, Kapil Gupta, Deepak Balaji Govinda Raj, Alice Aubert, Petra Dmcova, Frederic Garzoni, Daniel Fitzgerald and Imre Berger 14. Fundamentals of expression in mammalian cells; Michael R. Dyson 15. Assembling multi-subunit complexes using mammalian expression; Bahar Baser and Joop van den Heuvel Section 5: Plant expression 16. Microalgae as solar-powered protein factories; Franziska Hempel and Uwe G. Maier 17. Strategies and methodologies for the co-expression of multiple proteins in plants; Albert Ferrer, Montserrat Arró, David Manzano and Teresa Altabella 18. Transient expression systems in plants—potentialities and constraints; Tomas Canto Section 6: Complex reconstitution 19. Complex reconstitution from individual protein modules; Jérome Basquin, Michael Taschner and Esben Lorentzen 20. Structural reconstruction of protein-protein complexes involved in intracellular signaling; Klára Kirsch, Péter Sok, and Attila Remény Section 7: Biophysical methods to assess protein complexes 21. The use of small-angle scattering for the characterization of multi subunit complexes; Adam Round22. Application of nuclear magnetic resonance and hybrid methods to structure determination of complex systems. Filippo Prischi and Annalisa Pastore
£143.99
Birkhauser Verlag AG Molecular Determinants of Head and Neck Cancer
Book SynopsisSquamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.Trade Review“The book is intended primarily for clinicians, fellows, interns, and trainees, but medical students who may be interested in head and neck cancer but face the challenge of updating themselves on the latest innovations may also find this book very useful. … this is an informative and authoritative book on the subject that includes experiences from clinicians and scientists working on head and neck cancer at some of the most renowned cancer centers in the world.” (Ravi Salgia, Doody's Book Reviews, March, 2019)Table of ContentsChapter 1: Overview: B. Burtness and E. GolemisChapter 2: HER inhibition in HNC: E. Golemis and B. BurtnessChapter 3: MET: T Beck, Fox Chase Cancer CenterChapter 4: PI3K/mTOR/AMPK: C. Chung, Moffit Cancer CenterChapter 5: Jak/STAT: J.R. Grandis, UCSFChapter 6: TGFb: Neiman and Wang, University of ColoradoChapter 7: Wnt and catenin Signaling: MA Kukurusinska, Boston UniversityChapter 8: P53/p63/p73: B. BurtnessChapter 9: DNA damage: R. Bindra, Yale UniversityChapter 10: APOBEC Proteins: K.S. Anderson, Yale UniversityChapter 11: Hypoxia, including HIF1: Q. Le, Stanford UniversityChapter 12: VEGF/Angiogenesis and Antiangiogenic Therapy: A Argiris, Thomas Jefferson UniversityChapter 13: Sequencing/genomic insights: J.Myers, MD AndersonChapter 14: Gene expression, Methylation, and histones: R.Mehra, A.Andrews, S.Peri, Fox Chase Cancer Center and A.Bhatia, Yale UniversityChapter 15: Inflammation: Carter Van Waes, NIHChapter 16:Immunotherapy: Ferris and Baumann, UPMCChapter 17: FAK/Integrin pathway inhibitors: Nils Cordes, DresdenChapter 18: Targeting cell cycle controls: E.GolemisChapter 19: Head and neck cancer stem cells: L.Bourguignon, UCSFChapter 20: Non-coding RNAs: C.Punyadeera, Queensland UniversityChapter 21: Epidemiology of HPV: Ragin and Lui, Fox Chase Cancer CenterChapter 22: DNA damage in HPV-positive SCCHN: WG Yarbrough, Yale UniversityChapter 23: Treatment paradigms in HPV-positive SCCHN: A Cmelak, Vanderbilt University
£999.99
Springer International Publishing AG Pollen Tip Growth: From Biophysical Aspects to Systems Biology
a huge range and FREE tracked UK delivery on ALL orders.
£116.99
Springer International Publishing AG Psychrophiles: From Biodiversity to Biotechnology
a huge range and FREE tracked UK delivery on ALL orders.
£999.99
Springer International Publishing AG RNA Metabolism and Gene Expression in Archaea
Book SynopsisThis book focuses on the regulation of transcription and translation in Archaea and arising insights into the evolution of RNA processing pathways. From synthesis to degradation and the implications of gene expression, it presents the current state of knowledge on archaeal RNA biology in 13 chapters. Topics covered include the modification and maturation of RNAs, the function of small non-coding RNAs and the CRISPR-Cas defense system. While Archaea have long been considered exotic microbial extremophiles, they are now increasingly being recognized as important model microorganisms for the study of molecular mechanisms conserved across the three domains of life, and with regard to the relevance of similarities and differences to eukaryotes and bacteria. This unique book offers a valuable resource for all readers interested in the regulation of gene expression in Archaea and RNA metabolism in general.Table of ContentsI. RNA synthesis Systems approaches to genome occupancy and output of the archaeal transcription machineryMechanisms of transcription regulation in archaea2. RNAdegradingenzymesArchaeal ExosomeRNA-degrading enzymes in Archaea3.Translation, tRNA&rRNA processingArchaeal translationLife and Death of Ribosomes in ArchaeaStructure and Function of archaeal RNase PComplex Biosynthesis of N6-threonyl-carbamoyl adenosine - an anti-frameshift nucleoside4.Non codingRNAsEvolution of C/D box sRNAsComputational Screens for C/D Box and H/ACA sRNAs, and Potential New Roles in RegulationSmall non coding RNAs in methanogenic ArchaeaSmall non coding RNAs in halophilic Archaea5.CRISPR defense systemCRISPR-Cas systems in Haloarchaea
£999.99
Wiley-VCH Verlag GmbH Modern Biophysical Chemistry: Detection and
Book SynopsisThis updated and up-to-date version of the first edition continues with the really interesting stuff to spice up a standard biophysics and biophysical chemistry course. All relevant methods used in current cutting edge research including such recent developments as super-resolution microscopy and next-generation DNA sequencing techniques, as well as industrial applications, are explained. The text has been developed from a graduate course taught by the author for several years, and by presenting a mix of basic theory and real-life examples, he closes the gap between theory and experiment. The first part, on basic biophysical chemistry, surveys fundamental and spectroscopic techniques as well as biomolecular properties that represent the modern standard and are also the basis for the more sophisticated technologies discussed later in the book. The second part covers the latest bioanalytical techniques such as the mentioned super-resolution and next generation sequencing methods, confocal fluorescence microscopy, light sheet microscopy, two-photon microscopy and ultrafast spectroscopy, single molecule optical, electrical and force measurements, fluorescence correlation spectroscopy, optical tweezers, quantum dots and DNA origami techniques. Both the text and illustrations have been prepared in a clear and accessible style, with extended and updated exercises (and their solutions) accompanying each chapter. Readers with a basic understanding of biochemistry and/or biophysics will quickly gain an overview of cutting edge technology for the biophysical analysis of proteins, nucleic acids and other biomolecules and their interactions. Equally, any student contemplating a career in the chemical, pharmaceutical or bio-industry will greatly benefit from the technological knowledge presented. Questions of differing complexity testing the reader's understanding can be found at the end of each chapter with clearly described solutions available on the Wiley-VCH textbook homepage under: www.wiley-vch.de/textbooksTable of ContentsIntroduction: What is Biophysical Chemistry? - An Example from Drug Screening PART I: Basic Methods in Biophysical Chemistry BASIC OPTICAL PRINCIPLES Introduction What Does the Electronic Structure of Molecules Look Like? Orbitals, Wave Functions and Bonding Interactions How Does Light Interact with Molecules? Transition Densities and the Transition Dipole Moment Absorption Spectra of Molecules in Liquid Environments. Vibrational Excitation and the Franck-Condon Principle What Happens After Molecules have Absorbed Light? Fluorescence, Nonradiative Transitions and the Triplet State Quantitative Description of all Processes: Quantum Efficiencies, Kinetics of Excited State Populations and the Jablonski Diagram Problems OPTICAL PROPERTIES OF BIOMOLECULES Introduction Experimental Determination of Absorption and Fluorescence Spectra Optical Properties of Proteins and DNA Optical Properties of Important Cofactors BASIC FLUORESCENCE TECHNQUES Introduction Fluorescent Labelling and Linking Techniques Fluorescence Detection Techniques Fluorscence Polarization Anisotropy Forster Resonance Energy Transfer Fluorescence Kinetics Fluorescence Recovery after Photobleaching Biochemiluminescence CHIROPTICAL AND SCATTERING METHODS Chiroptical Methods Light Scattering Vibrational Spectra of Biomolecules MAGNETIC RESONANCE TECHNIQUES Nuclear Magnetic Resonance of Biomolecules Electron Paramagnetic Resonance MASS SPECTROMETRY Introduction MALDI-TOF ESI-MS Structural and Sequence Analysis Using Mass Spectrometry PART II: Advanced Methods in Biophysical Chemistry FLUORESCENCE MICROSCOPY Introduction Conventional Fluorescence Microscopy Total Internal Reflection Fluorescence Microscopy Light-Sheet Microscopy SUPER-RESOLUTION FLUORESCENCE MICROSCOPY Stimulated Emission Depletion (STED) Microscopy Photoactivated Localization Microscopy (PALM) and Stochastic Optical Reconstruction Microscopy (STORM) 3D Super-Resolution Fluorescence Microscopy Imaging of Live Cells Multicolour Super-Resolution Fluorescence Microscopy Structured Illumination Microscopy SOFI Final Comparison SINGLE-BIOMOLECULE TECHNIQUES Introduction Optical Single-Molecule Detection Fluorescence Correlation Spectroscopy Optical Tweezers Atomic Force Microscopy of Biomolecules Patch Clamping ULTRAFAST- AND NONLINEAR SPECTROSCOPY Introduction Nonlinear Microscopy and Spectroscopy Ultrafast Spectroscopy DNA SEQUENCING AND NEXT-GENERATION SEQUENCING METHODS Sanger Method Next-Generation Sequencing Methods SPECIAL TECHNIQUES Introduction Fluorescing Nanoparticles Surface Plasmon Resonance Detection DNA Origami DNA Microarrays Flow Cytometry Fluorescence In Situ Hybridization Microspheres and Nanospheres ASSAY DEVELOPMENT, READERS AND HIGH-THROUGHPUT SCREENING Introduction Assay Development and Assay Quality Microtitre Plates and Fluorescence Readers Application Example: Drug Discovery and High-Throughput Screening Index
£51.00
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Stereochemistry - Workbook: 191 Problems and Solutions
Book SynopsisThis workbook in stereochemistry is designed for students, lecturers and scientists in chemistry, pharmacy, biology and medicine who deal with chiral chemical compounds and their properties. It serves as a supplement to textbooks and seminars and thus provides selected examples for students to practice the use of the conventions and terminology for the exact three-dimensional description of chemical compounds. It contains 191 problems with extended solutions. Trade ReviewThe late Edgar Heilbronner, one of the great physical and organic chemists of the 20th century, had a particularly effective lecture. He started it as follows: "You know pretty much everything I am going to say. So let us begin with the questions." And up on the screen flashed the first question. The lecture continued in the same vein; Heilbronner’s carefully structured answers to just the right questions led to a fascinating seminar, and a learning experience. I thought of Edgar Heilbronner’s lecture as I read the Hellwich and Siebert "Stereochemistry Workbook." In it are 191 graduated problems, along with succinct and clear solutions. One has to know a little stereochemical lore to begin with, for instance the priority rules of the CIP system. But otherwise everything is taught, in exemplary fashion, just through the progression of questions and answers. Complexities of naming coordination compounds, and dealing with chirality planes and axes are not avoided. The examples grow increasingly challenging. The success of this small volume lies in the fact it has a hidden narrative structure. Complexity is introduced in stages; solutions to the problems are attainable goals. One is drawn in, it is fun to go on. And the book is decorated with fascinating short stories of pharmaceutical design and utility. We have here a rare instance of a well-designed workbook that constructs a learning experience better than that found in most textbooks. What more would I want to see in it? The ordinary (of reasonable Lewis structures, normal bond lengths, moderate temperature [T less than ~100 °C]) which is the province of the beautiful compounds that are discussed in this book, needs to be defined. The ordinary is not diminished by what constrains it, for the fantastic variety the normal world generates suffices. But it is good to be aware of just what the assumptions are. Let me give an example. In one problem, a set of isomers of a bicyclic compound (cyclothiazide) is eliminated from discussion because a bridge can be formed only by cis fusion. In another example, two isomers of a [CoCl2(H2NNH2)(PPh3)2] complex are said to be not possible, those where the H2NNH2 would bridge trans-positions on the octahedral metal. Indeed, both statements make sense, but it would be interesting to mention why they are true (strain, the long N–N bond necessary). And how it is in the nature of chemists to subvert the impossible, and what ingenious molecules might do if there is no option but the energetically costly impossible. "Stereochemistry Workbook," one of the most effective pedagogical texts I’ve encountered, re-emphasizes the fundamental role of geometry in chemistry. Molecules have shapes. The logic of isomerism, in all its manifestations, the life-and-death-determining necessity of describing three-dimensional geometry, our representational struggles to do so – these define the beauty of chemistry. (Roald Hoffmann, Cornell University, Beilstein Journal of Organic Chemistry 2009, 5, No. 38)Table of ContentsQuestions.- Answers.
£29.69
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Colloid Chemistry II
a huge range and FREE tracked UK delivery on ALL orders.
£161.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG New Aspects in Phosphorus Chemistry III
a huge range and FREE tracked UK delivery on ALL orders.
£170.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Biotechnology for the Future
a huge range and FREE tracked UK delivery on ALL orders.
£161.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Immobilisation of DNA on Chips I
a huge range and FREE tracked UK delivery on ALL orders.
£999.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Heterocyclic Antitumor Antibiotics
a huge range and FREE tracked UK delivery on ALL orders.
£161.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Bioactive Heterocyles I
a huge range and FREE tracked UK delivery on ALL orders.
£221.27
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Bioactive Heterocycles II
a huge range and FREE tracked UK delivery on ALL orders.
£161.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Bioactive Heterocycles III
a huge range and FREE tracked UK delivery on ALL orders.
£999.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Bioactive Heterocycles IV
a huge range and FREE tracked UK delivery on ALL orders.
£999.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Sparking Signals: Kinases as Molecular Signaltransducers and Pharmacological Drug Targets in Inflammation
a huge range and FREE tracked UK delivery on ALL orders.
£999.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Bioactive Molecules and Medicinal Plants
a huge range and FREE tracked UK delivery on ALL orders.
£250.92
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Anthracycline Chemistry and Biology II: Mode of Action, Clinical Aspects and New Drugs
Book SynopsisThis series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts. The series is still valid and useful after five or ten years. More information as well as the electronic version of the whole content is available at: springerlink.com.Table of ContentsG.L. Beretta, F. Zunino: Molecular Mechanisms of Anthracycline Activity.- P. Menna, E. Salvatorelli, L. Gianni, G. Minotti: Anthracycline Cardiotoxicity.- M.L. Capobianco, C.V. Catapano: Daunomycin-TFO Conjugates for Downregulation of Gene Expression.- F. Kratz: Acid-Sensitive Prodrugs of Doxorubicin.- J.-C. Florent, C. Monneret: Doxorubicin Conjugates for Selective Delivery to Tumors.- T.H. Koch, B.L. Barthel, B.T. Kalet, D.L. Rudnicki, G.C. Post, D.J. Burkhart: Anthracycline–Formaldehyde Conjugates and Their Targeted Prodrugs - F.-M. Arcamone: Sabarubicin.- M. Broggini: Nemorubicin
£179.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Sulfur Assimilation and Abiotic Stress in Plants
a huge range and FREE tracked UK delivery on ALL orders.
£161.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Enzyme Handbook 7: Class 1.5–1.12: Oxidoreductases
a huge range and FREE tracked UK delivery on ALL orders.
£85.49
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research
Book SynopsisMetabolic research and especially that which focuses on the monooxygenase cytochrome P450 system has gone through dramatic progressive changes within the last decade. Availability of highly sophisticated analytical techniques has contributed to increased molecular understanding of biotransformation pathways. Nowadays designer drugs are computer composable focussing on metabolic stability. The rapid development of recombinant enzymes has, in many cases, replaced the intensive work on P450 isolation from naturally occurring sources. Recombinant P450s can be expressed in cell lines and thus made available for reproducible and constant use addressig a large number of scientific questions. This book describes the present position of such research.Table of Contents1 Xenobiotic Metabolism: From Intact Biosystem to Single Enzymes.- 2 Regulation of Xenobiotic-Metabolizing Cytochromes P450.- 3 Cytochrome P450 in Human Drug Metabolism: How Much Is Predictable?.- 4 Metabolic Activation of Anticancer Oxazaphosphorines by Cytochrome P450s: Development of a Model for Cancer Gene Therapy.- 5 The Use of Bacteria for Cytochrome P450 Expression.- 6 Expression of Cytochromes P450 in Yeast: Practical Aspects.- 7 Human Cells as an Expression System for Cytochromes P450.- 8 Metabolic Reactions and Recombinant Isoenzymes of Cytochrome P450: Information Generated and Value for Pharmaceutical Development.- 9 The Importance of Cytochrome P450 3A Enzymes in Drug Metabolism.- 10 Strategies for Verifying the Involvement of Specific Cytochrome P450 Enzymes in Xenobiotic Metabolism.- 11 Regulation of Cytochromes P450 by Substrate Interactions.- 12 Strategies for the Use of Single Cytochrome P450 Enzymes in Drug Research and Future Prospects.
£40.49
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Biopolymers · PVA Hydrogels Anionic Polymerisation Nanocomposites
a huge range and FREE tracked UK delivery on ALL orders.
£161.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Sensing with Ion Channels
a huge range and FREE tracked UK delivery on ALL orders.
£123.49
