Description
Book SynopsisProstaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from and lipoxygenase pathways, respec arachidonic acid) via the cyclooxygenase tively. Cyclooxygenase products consist of diverse products such as prosta glandin E2 (POE), prostacyclin (POI) and thromboxane A2 (TXA), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy
Table of Contents1. Arachidonic Acid Metabolism in the Skin.- 2. Arachidonic Acid Metabolism and Tumor Promotion.- 3. Prostaglandins, Epidermal Hyperplasia and Skin Tumor Promotion.- 4. Effects of Phorbol Esters on Phospholipid Metabolism in Vitro.- 5. Tumor Promoting Phorbol Esters May Affect Cell Membrane Signal Transmission by Protein Kinase.- 6. Active Oxygen and Promotion.- 7. Possible Involvement of Arachidonate Products in Tumor Promoter Inhibition of Cell-Cell Communication.- 8. Proteases and Cyclic Nucleotides.- Perspectives.
