Biochemistry Books

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

Book SynopsisIdeal for readers encountering biochemistry for the first time, Garrett and Grisham's BIOCHEMISTRY, Seventh Edition, makes even complex course concepts more accessible while revealing the beauty and usefulness of biochemistry in the everyday world. This engaging text illuminates the fundamental principles governing the structure, function and interactions of biological molecules, providing a solid foundation in biochemistry whether you are an undergraduate majoring in life sciences, chemistry or premedical programs, or a medical or graduate health sciences student seeking a deeper understanding of human physiology. Updated to reflect tremendous recent developments in biochemistry, the Seventh Edition features new and revised material and presentations throughout the text, incorporating additional content while maintaining a balanced and streamlined presentation. In addition, the authors emphasize the interrelationships of ideas to help you appreciate the overarching questions of biocheTable of ContentsPart I: MOLECULAR COMPONENTS OF CELLS. 1. The Facts of Life: Chemistry is the Logic of Biological Phenomena 1. 2. Water: The Medium of Life. 3. Thermodynamics of Biological Systems. 4. Amino Acids and the Peptide Bond. 5. Proteins: Their Primary Structure and Biological Functions. 6. Proteins: Secondary, Tertiary and Quaternary Structure. 7. Carbohydrates and the Glycoconjugates of Cell Surfaces. 8. Lipids. 9. Membranes and Membrane Transport. 10. Nucleotides and Nucleic Acids. 11. Structure of Nucleic Acids. 12. Recombination, Cloning, Gene Editing and Synthetic Biology--An Introduction. Part II: PROTEIN DYNAMICS. 13. Enzymes--Kinetics and Specificity. 14. Mechanisms of Enzyme Action. 15. Enzyme Regulation. 16. Molecular Motors. Part III: METABOLISM AND ITS REGULATION. 17. Metabolism: An Overview. 18. Glycolysis. 19. The Tricarboxylic Acid Cycle. 20. Electron Transport and Oxidative Phosphorylation. 21. Photosynthesis. 22. Gluconeogenesis, Glycogen Metabolism and the Pentose Phosphate Pathway. 23. Fatty Acid Catabolism. 24. Lipid Biosynthesis. 25. Nitrogen Acquisition and Amino Acid Metabolism. 26. Synthesis and Degradation of Nucleotides. 27. Metabolic Integration and Organ Specialization. Part IV: INFORMATION TRANSFER. 28. DNA Metabolism: Replication, Recombination and Repair. 29. Transcription and the Regulation of Gene Expression. 30. Protein Synthesis. 31. Completing the Protein Life Cycle: Folding, Processing and Degradation. 32. The Reception and Transmission of Extracellular Information.

Read more less

Book SynopsisOxidative Eustress in Exercise Physiology unravels key physiological responses and adaptations to different redox-regulated exercise paradigms at the cell, tissue, and whole-body level in model systems and humans in health and disease. While the mechanistic details are still unclear, key intracellular redox indices seem to be dysregulated with age. Consequently, beneficial molecular responses to acute endurance exercise decline in older individuals. Recent research suggests that manipulating mitochondrial redox homeostasis by supplementing with the mitochondria-targeted coenzyme Q10 for six weeks markedly improves physical function in older adults; i.e. it may be possible to maximise the benefits of exercise by manipulating the redox environment. The research described in this book suggests that significant translational potential exists with respect to cardiovascular disease, neurodegeneration and cancer. An international team of researchers documents the

Read more less

Book SynopsisProteomics aims to study all the proteins of human and other living systems, as well as their properties to provide an integrated view of cellular processes. The study of proteomics involves the application of rapidly evolving high-throughput technologies and new platforms that are coming forward regularly, providing versatile novel tools for biomedical and pharmaceutical applications. This book provides a detailed understanding of the basics of proteins and proteomics, gel based-proteomics techniques, basics of mass spectrometry and quantitative proteomics, interactomics: basics and applications, and advancements in proteomics. It also covers basic knowledge about sample preparation, mass spectrometry workflow, different chromatography technologies and quantitative proteomics.The text highlights the application and challenges of various high-throughput integrated proteomics technologies capable of fast and accurate screening of thousands of biomolecules, which are fouTable of ContentsModule 1: Basics of proteins and proteomicsBasics of amino acids and proteinsProtein chemistry to proteomicsModule 2: Gel-based proteomics techniquesGel-based proteomics2-d difference in gel electrophoresis (2d-dige)Gel-based proteomic data analysisModule 3: Basics of mass-spectrometry and quantitative proteomicsIntroduction to mass spectrometryHybrid mass spectrometry configurationsTandem mass spectrometry for protein identificationIn vitro quantitative proteomics using itraqIn vivo quantitative proteomics using silacModule 4: Interactomics: basics and applicationIntroduction to interactomicsAntigen and antibody microarraysCell-free expression based protein microarraysNucleic acid programmable protein arraysLabel-free proteomicsSurface plasmon resonanceSurface plasmon resonance imagingProtein interaction analysis using spr and spriModule 5: Advancement in proteomicsProteomics for translational researchFuture of proteomics for clinical applicationsChallenges in clinical proteomics

Read more less

Book SynopsisThe IACUC Administratorâs Guide to Animal Program Management supports IACUC administrators who assist with developing, managing, and overseeing a program of animal care and animal use. It provides many options and possibilities for specific operational practices (e.g., how to build a well-functioning IACUC, what a functional protocol template looks like) to satisfy regulatory requirements.The material provided is a compilation of several years of Best Practices (BP) meetings among IACUC administrators across the country. The BP meetings included representatives from the NIH/OLAW, AAALAC, and the USDA, whose presence and dialogue assured the BP discussion met or exceeded all regulatory or accreditation minimum standards. BP meeting attendees from private, public, governmental, and academic organizations have helped to shape and develop the information offered herein. It is through the insight of several hundred colleaguesâtheir successes as well as theiTrade Review"The IACUC Administrator’s Guide to Animal Program Management is tailored to meet the needs of IACUC Administrators, Attending Veterinarians (AVs) and/or Animal Research Directors involved with developing, managing, and overseeing a program of animal care and use. While the Federal regulations (AWA act) and standards such as the guide for "The care and use of laboratory animals" help set the expectations for lab animal programs they do not provide clear guidance on the methods that need to be in place especially at the IACUC level to help balance compliance and animal welfare adequately. The authors have tried to bridge this gap by compiling shared best practices from animal program administrators across a wide spectrum of institutions ranging from academia, government and private organizations. …A special feature of the book is the inclusion of chapters on FOIA, Sunshine laws and the DOD/VA regulations. This has not been traditionally addressed in other books of this nature. We especially loved reading chapter 4, The Animal Care and Use Program and chapter 5, Protocol Review and Approval for the content and concise detail. …The authors have done a great job highlighting the issue as well as providing different practices that IACUC’s can adopt to overcome this situation. Chapter 8, Animal Care and Use Program Review was also very well written and could act as a significant resource for administrators to use when training IACUC members on how to conduct and participate in a program reviews. Overall the details, real life scenarios and wide range of topics makes this a must have book for IACUC administrators and program directors. This could be especially valuable to individuals new to the field, lab animal residents and a resource book for those seeking certification as a professional IACUC administrator." Jennifer McElroy, RVT, CPIA and Dr. Jeetendra Eswaraka, DVM, PhD, DACLAM in Laboratory AnimaTable of ContentsAn Introduction to Best Practices Meetings. The IACUC Administrator’s Office Structure. The IACUC Administrator’s Role and Responsibilities. The Animal Care and Use Program. Protocol Review and Approval. Protocol Noncompliance. Protocol and Grant Congruency. Animal Care and Use Program Review. Semiannual Facility Inspection. Monitoring the Animal Care and Use Program. Facilitating Communication. Field Studies. Personnel Qualifications and Training Programs. Tracking Animal Use on Protocols. Veterinary Care Programs. Whistle-Blower Policy. Occupational Health and Safety Program. Emergency Disaster Plans. The Role of a Primary Grantee. FOIA, Sunshine Laws, and Confidential Information. DOD and VA Regulations—Know the Differences. Data Management and Electronic Systems. Policies, Guidelines, and Standard Operating Procedures. Appendices.

Read more less

Book SynopsisMedical Biochemistry at a Glance is a concise, illustrated summary of biochemistry and its relevance to clinical medicine. It is intended for students of medicine and the biomedical sciences such as nutrition, biochemistry, sports science, medical laboratory sciences, physiotherapy, pharmacy, physiology, pharmacology and veterinary science.Trade ReviewI have taught biochemistry to medical students and to undergraduates and graduate students, at both Temple University School of Medicine and at Case Western Reserve University, since 1968, so that I have had a great deal of experience in the field and have a feel for what works well for medical students. Medical Biochemistry at a Glance would be an excellent book for USMLE Step 1. In my experience, medical students (and pre-medical students) would greatly benefit from reading it in preparation for the exam. This compares very well with Lippincott’s Biochemistry - this has the right price and approach to compete with Lippincott for a less expensive and more accessible alternative to the larger text books that are out there. I like the way it combines the metabolic pathways and principles in such a creative fashion, and the metabolism sections are among the best I have read and the easiest to understand. Metabolism is a very complicated subject and, in my experience, most teachers of the subject would really benefit from your text. (Richard W. Hanson, Case Western Reserve University School of Medicine)Table of ContentsPreface to the third edition 7 Acknowledgements to the third edition 7 Figure key 8 SI/mass unit conversions 9 Part 1 Acids, bases and pH 1 Acids, bases and hydrogen ions (protons) 10 2 Understanding pH 12 3 Production and removal of protons into and from the blood 14 4 Metabolic alkalosis and metabolic acidosis 16 5 Respiratory alkalosis and respiratory acidosis 18 Part 2 Structure of amino acids and proteins 6 Amino acids and the primary structure of proteins 20 7 Secondary structure of proteins 22 8 Tertiary and quaternary structure and collagen 24 Part 3 Formation of ATP: oxidation and reduction reactions 9 Oxidation/reduction reactions, coenzymes and prosthetic groups 26 10 Anaerobic production of ATP by substrate-level phosphorylation, from phosphocreatine and by the adenylate kinase (myokinase) reaction 28 11 Aerobic production of ATP 30 12 Biosynthesis of ATP by oxidative phosphorylation I 32 13 Biosynthesis of ATP by oxidative phosphorylation II 34 14 What happens when protons or electrons leak from the respiratory chain? 36 15 Free radicals, reactive oxygen species and oxidative damage 38 16 Aerobic oxidation of glucose to provide energy as ATP 40 17 Anaerobic oxidation of glucose by glycolysis to form ATP and lactate 42 18 Anaerobic glycolysis in red blood cells, 2,3-BPG (2,3-DPG) and the Bohr effect 44 Part 4 Carbohydrates 19 Carbohydrates 46 20 Absorption of carbohydrates and metabolism of galactose 48 21 Fate of glucose in liver: glycogenesis and lipogenesis 50 22 Fructose metabolism 52 23 Glucose homeostasis 54 24 Glucose-stimulated secretion of insulin from β-cells 56 25 Regulation of glycogen metabolism 58 26 Glycogen breakdown (glycogenolysis) and glycogen storage diseases 60 27 Insulin signal transduction and diabetes mellitus 62 28 Diabetes mellitus 64 29 Alcohol metabolism: hypoglycaemia, hyperlactataemia and steatosis 66 Part 5 Enzymes and regulation of pathways 30 Enzymes: nomenclature, kinetics and inhibitors 68 31 Regulation of enzyme activity 70 32 Regulation of glycolysis and Krebs cycle 72 33 Oxidation of fatty acids to produce ATP in muscle and ketone bodies in liver 74 34 Regulation of lipolysis, β-oxidation, ketogenesis and gluconeogenesis 76 Part 6 Lipids and lipid metabolism 35 Structure of lipids 78 36 Phospholipids I: phospholipids and sphingolipids 80 37 Phospholipids II: micelles, liposomes, lipoproteins and membranes 82 38 Metabolism of carbohydrate to cholesterol 84 39 VLDL and LDL metabolism I: “forward” cholesterol transport 86 40 VLDL and LDL metabolism II: endogenous triacylglycerol transport 88 41 HDL metabolism: “reverse” cholesterol transport 90 42 Absorption and disposal of dietary triacylglycerols and cholesterol by chylomicrons 92 43 Steroid hormones: aldosterone, cortisol, androgens and oestrogens 94 Part 7 Metabolism of amino acids and porphyrins 44 Urea cycle and overview of amino acid catabolism 96 45 Non-essential and essential amino acids 98 46 Amino acid metabolism: to energy as ATP; to glucose and ketone bodies 100 47 Amino acid disorders: maple syrup urine disease, homocystinuria, cystinuria, alkaptonuria and albinism 102 48 Phenylalanine and tyrosine metabolism in health and disease 104 49 Products of tryptophan and histidine metabolism 106 50 Haem, bilirubin and porphyria 108 Part 8 Vitamins 51 Fat-soluble vitamins I: vitamins A and D 110 52 Fat-soluble vitamins II: vitamins E and K 112 53 Water-soluble vitamins I: thiamin, riboflavin, niacin and pantothenate 114 54 Water-soluble vitamins II: pyridoxal phosphate (B6) 116 55 Water-soluble vitamins III: folate and vitamin B12 118 56 Water-soluble vitamins IV: biotin and vitamin C 120 Part 9 Molecular biology 57 The cell cycle 122 58 Pyrimidine metabolism 124 59 Purine metabolism 126 60 Structure of DNA 128 61 The “central dogma” of molecular biology 130 62 Organisation of DNA in chromosomes 132 63 Replication of DNA (part 1) 134 64 Replication of DNA (part 2) 136 65 DNA damage and repair 138 66 Transcription of DNA to make messenger RNA (part 1) 140 67 Transcription of DNA to make messenger RNA (part 2) 142 68 Transcription of DNA to make transfer RNA 144 69 Transcription of DNA to make ribosomal RNA 146 70 Translation and protein synthesis 148 71 Comparison of DNA replication, DNA transcription and protein synthesis in eukaryotes and prokaryotes 150 Part 10 Diagnostic clinical biochemistry 72 Diagnostic clinical biochemistry (with Dr J. W. Wright FRCP, MRCPath) 152 Index 154

Read more less

Book SynopsisMedicinal Chemistry teaches essential concepts by focusing on how the field is actually practiced, melding real-world research experience with basic principles and modern methods. Written by practicing medicinal chemists, this textbook is intended for advanced undergraduates and first-year graduate students in biology, chemistry, and biochemistry. Pre-medical or pre-pharmacy students and professionals entering the drug discovery field will also find it a useful reference. Building on a foundation of synthetic organic chemistry and structural biology, the book interweaves therapeutics, case studies, historical context, and techniques for discovering, developing, and optimizing new drugs. Chapters are richly illustrated and include problems and annotated journal references with accompanying exercises and answers. Authored by practicing medicinal chemistsâmelding real-world research experience with basic concepts and up-to-date methods Flexible in presentationâ the first five chapters provide a conceptual foundation and historical understanding of the field; subsequent chapters explore the application of concepts. Chapters can be assigned in order of instructor preference and desired emphasis Presents easy-to-follow tables and descriptions of assays next to their relevance to medicinal chemistry and drug discovery, along with target valuesâinformation rarely found all in one place, but is a crucial reference Case studies and Journal Club use current literature to apply concepts from the text to real-life examples. They are also suitable for flipped classrooms and self-study Table of ContentsPART I: Drug Discovery and Development 1. Historical Perspective and Overview of Drug Discovery 2. Drug discovery: Hit and Lead Discovery 3. Drug Discovery: Optimization of Lead Properties PART II: Classes of Drug Targets 4. Medicinal Chemistry Strategies Used in Lead Optimization 5. The Process of Developing a Drug from an Optimized Lead 6. Receptors as Drug Targets 7. Enzymes as Drug Targets 8. Protein-Protein Interactions and Lipids as Drug Targets 9. DNA and RNA as Drug Targets PART III: Selected Therapeutic Areas 10. Anti-Cancer Drugs 11. Infectious Diseases I: Antiviral and Antifungal Drugs 12. Infectious Diseases II: Antibacterial and Antiparasitic Drugs 13. Drugs Acting on the CNS

Read more less

Book SynopsisThis leading textbook in the field examines the mechanisms underlying toxicity, particularly the events at the molecular level and the factors that determine and affect toxicity. The new edition is updated to reflect the latest research into the biochemical basis of toxicology and the growing concerns over the adverse effects of drugs, environmental pollution, and occupational hazards.Principles of Biochemical Toxicology, Fourth Edition thoroughly explains dose-response relationships, disposition and metabolism, and toxic responses to foreign compounds, and presents detailed examples to make the mechanisms of toxicity more accessible to students encountering the subject for the first time. Comprehensive in scope with a clear and concise approach, the text includes summary sections, questions and model answers, and thoroughly revised artwork that serves as an essential aid to learning and teaching.New to the Fourth Edition: reorganized sections that cover basic principles followed by sections on different types of toxicity extensive use of examples throughout and numerous explanatory diagrams new material on risk assessment, export systems, oxidative stress, Thalidomide, Tamoxifen and asbestos proliferators, domoic acid, bone marrow (benzene), heart (adriamycin), blood (primaquine), biomarkers, cytochrome P450 and other enzymes, receptor mediated effects, endocrine disruption, ethanol, botox, arsenic, and more questions with answers for each chapter for review and self-checking expanded and updated chapter bibliographies Table of Contents1. Dose-response Relationships. 2. Factors Affecting Toxic Responses: Disposition. 3. Factors Affecting Toxic Responses: Metabolism. 4. Factors Affecting Metabolism, Disposition and Toxicity. 5. Toxic Responses to Foreign Compounds. 6. Biochemical Mechanisms of Toxicity: Specific Examples.

Read more less

Book Synopsis Biophysical Chemistry explores the concepts of physical chemistry and molecular structure that underlie biochemical processes. Ideally suited for undergraduate students and scientists with backgrounds in physics, chemistry or biology, it is also equally accessible to students and scientists in related fields as the book concisely describes the fundamental aspects of biophysical chemistry, and puts them into a biochemical context.This second edition has been fully updated throughout with novel techniques, with a new chapter on advances in cryo-electron microscopy and exciting new content throughout on big data techniques, structural bioinformatics, systems biology and interaction networks, and artificial intelligence and machine learning.The book is organized in four parts, covering thermodynamics, kinetics, molecular structure and stability, and biophysical methods. Cross-references within and between these parts emphasize common themes and highlight recurrent

Read more less

Book SynopsisFood ingredients are important molecules of the most diverse chemical classes responsible for conferring nutrition, stability, color, flavor, rheological and sensorial characteristics, in addition to several other important uses in the food industry. In this way, the production routes of these ingredients have gained more and more attention from consumers and producing industries, who expect that, in addition to their technological properties, these ingredients are still obtained without synthetic means, with savings of natural resources and mainly with less environmental impact. This book is intended for bioengineers, biologists, biochemists, biotechnologists, microbiologists, food technologists, enzymologists, and related professionals/ researchers. â Explores recent advances in the valorization of agri-food waste into food ingredients â Provides technical concepts on the production of various food ingredients of commercial interestâ Explores novel technologically advanced strategies for the extraction of bioactive compounds from food wastesâ Presents important classes of food ingredients obtained from alternative raw materialsâ Presents sustainable food waste resources and management strategiesâ Presents different pretreatment technologies and green extraction methodologies to support a green environment in the circular economy concept.â Challenges in applications of re-derived bioactive compounds from food wastes in food formulations

Read more less

Book SynopsisOriginally published in 1990, this volume addresses issues surrounding global ecological changes and sustainability of present patterns of urbanisation and industrialisation.

Read more less

Book SynopsisThis book provides detailed concepts and information on principles and processes of signal analysis in pharmacovigilance along with case studies. It covers the fundamental concepts and principles of pharmacovigilance, emphasizing the need for robust signal detection and analysis methods. The book reviews the diverse array of databases and tools employed for signal detection, including electronic health records (EHRs), social media mining, claims data, and distributed data networks. In turn, the book discusses the application of molecular dynamics, molecular docking, and the use of the FDA Adverse Event Reporting System (FAERS) database in signal analysis. Toward the end, the book explores the identification, validation, and assessment of signals associated with vaccines. This book is useful for graduate, post-graduate students of pharmaceutical sciences, and scientists in pharmacology research and drug development.

Read more less

Book SynopsisEvery Molecule Matters is a successor to the authorâs earlier Every Molecule Tells a Story, and tells the story of a wide range of molecules. These range from the familiar odours which give pleasure to eating (and the spices that add piquancy) and the vitamins that are vital to our survival, to the way in which insects and plants use chemicals to protect themselves. Thereâs controversy, with the compounds of chlorine which range from life-supporting anaesthetics and natural antibiotics to insecticides like DDT, which saved innumerable lives but became an environmental cause-celebre. Through the addictive power of nicotine, smoking tobacco morphed from being a curiosity imported from the Americas to a megapound industry that left human illness and death in its wake. And how safe is vaping? Find out about the painkillers that have become drugs of abuse. And smile at the smelly sulphur compounds that are unpleasant human odorants (and defence molecules for skunks), control natural cycles in the environment or act as flavourings to wine. You will discover them all in here.This book displays the structures of hundreds of compounds, used by humans, animals and plants. Some are beneficial; some are not. Find out here why you should be better informed about them. This collection of molecules illustrates the relevance of chemistry in our everyday lives. The second edition is considerably expanded, and new areas include food chemistry, vitamins, drugs of abuse. New discoveries are reflected in existing chapters. The chemicals are frequently put in context of their human associations, so that the book goes beyond just âthe chemistryâ. A celebration of the molecules of chemistry.

Read more less

Book SynopsisESSENTIAL DEVELOPMENTAL BIOLOGY Discover the foundations of developmental biology with this up to date and focused resource from two leading experts The newly revised Fourth Edition of Essential Developmental Biology delivers the fundamentals of the developmental biology of animals. Designed as a core text for undergraduate students in their first to fourth years, as well as graduate students in their first year, the book is suited to both biologically based and medically oriented courses. The distinguished authors presume no prior knowledge of development, animal structure, or histology. The new edition incorporates modern single cell transcriptome sequencing and CRISPR/Cas9, as well as other methods for targeted genetic manipulation. The existing material has also been reorganized to provide for easier reading and learning for students. The book avoids discussions of history and experimental priority and emphasizes instead the modern advances in developmental biology. The authors have kept the text short and focused on the areas truly central to developmental biology. Readers will benefit from the inclusion of such topics as: A thorough discussion of the groundwork of developmental biology, including developmental genetics, cell signaling and commitment, and cell and molecular biology techniques An exploration of major model organisms, including Xenopus, the zebrafish, the chick, the mouse, the human, Drosophila, and Caenorhabditis elegans A treatment of organogenesis, including postnatal development, and the development of the nervous system, mesodermal organs, endodermal organs, and imaginal discs in drosophila A final section on growth, stem cell biology, evolution, and regeneration Perfect for undergraduate students, especially those preparing to enter teaching or graduate studies in developmental biology, Essential Developmental Biology will also earn a place in the libraries of those in the pharmaceutical industry expected to be able to evaluate assays based on developmental systems.Table of ContentsPreface, ix About the companion website, xi Section 1: Groundwork, 1 1 The excitement of developmental biology, 3 Where the subject came from, 3 Impact of developmental biology, 4 Future impact, 5 2 How development works, 7 Ultrashort summary, 7 Gametogenesis, 10 Early development, 13 Growth and death, 19 3 Approaches to development: developmental genetics, 25 Developmental mutants, 25 Sex chromosomes, 27 Maternal and zygotic, 27 Genetic pathways, 28 Genetic mosaics, 30 Screening for mutants, 31 Cloning of genes, 32 Gain-and loss-of-function experiments, 32 Transgenesis, 32 Other gain-of- function techniques, 34 Targeted mutagenesis, 34 Other loss-of- function systems, 35 Gene duplication, 36 Limitations of developmental genetics, 37 4 Approaches to development: experimental embryology and its molecular basis, 39 Normal development, 39 Developmental commitment, 42 Criteria for proof, 48 Transcription factors, 48 Transcription factor families, 50 Other controls of gene activity, 51 Signaling systems, 51 Genetic regulatory networks, 57 5 Approaches to development: cell and molecular biology techniques, 61 Microscopy, 61 Optical techniques, 61 Confocal, multi-photon, and light sheet microscopes, 63 Image capture, 63 Anatomical and histological methods, 64 Microinjection, 66 Study of gene expression by molecular biology methods, 67 Study of gene expression by in situ methods, 72 Reporter genes, 75 Cell-labeling methods, 76 6 Cells into tissues, 81 Cells in embryos, 81 Cytoskeleton, 82 Small GTP-binding proteins, 84 Extracellular matrix, 84 Cell movement, 85 Epithelial organization, 86 Morphogenetic processes, 88 Section 2: Major model organisms, 97 7 Major model organisms, 99 The big six, 99 Access and micromanipulation, 101 Genetics and genomes, 101 Relevance and tempo, 102 Other organisms, 102 8 Xenopus, 107 Oogenesis, maturation, and fertilization, 108 Normal development, 109 Fate maps, 114 Experimental methods, 115 Processes of regional specification, 119 9 The zebrafish, 135 Normal development, 135 Fate map, 140 Genetics, 141 Reverse genetic methods, 144 Embryological techniques, 145 Regional specification, 145 Other roles of the zebrafish, 150 10 The chick, 153 Normal development, 154 Fate map, 158 Regional specification of the early embryo, 159 Description of organogenesis in the chick, 164 11 The mouse, 173 Mammalian fertilization, 173 Normal development of the mouse, 177 Fate map, 184 Regional specification in the mouse embryo, 185 Transgenic mice, 190 Embryonic stem cells, 192 Knockouts and knock-ins, 192 Nuclear transplantation and imprinting, 196 X-inactivation, 196 Teratocarcinoma, 198 12 Human early development, 203 Human reproduction, 203 Preimplantation development, 205 Human embryonic stem cells, 207 Human postimplantation development, 208 Postimplantation diagnosis: chorionic villus sampling and amniocentesis, 211 Ethics of human development, 211 13 Drosophila, 217 Insects, 217 Normal development, 219 Fate map, 222 Pole plasm, 224 Drosophila developmental genetics, 224 The developmental program, 227 The dorsoventral pattern, 228 The anteroposterior system, 232 14 Caenorhabditis elegans, 247 Adult anatomy, 248 Embryonic development, 249 Regional specification in the embryo, 251 Analysis of postembryonic development, 259 The germ line, 262 Programmed cell death, 264 Section 3: Organogenesis, 269 15 Techniques for studying organogenesis and postnatal development, 271 Genetics, 271 Clonal analysis, 275 Tissue and organ culture, 278 Cell analysis and separation, 279 16 Development of the nervous system, 283 Overall structure and cell types, 283 Regional specification, 286 Neurogenesis and gliogenesis, 292 The neural crest, 299 Development of neuronal connectivity, 303 17 Development of mesodermal organs, 315 Somitogenesis, 315 Myogenesis, 322 The kidney, 323 Germ cell and gonadal development, 326 Sex determination, 330 Limb development, 330 Blood and blood vessels, 340 The heart, 343 18 Development of endodermal organs, 355 Normal development, 355 Organization of the gut tube, 356 Fate map of the endoderm, 359 Experimental analysis of endoderm development, 359 The pancreas, 366 19 Drosophila imaginal discs, 373 Metamorphosis, 373 Genetic study of larval development, 374 Disc development, 378 Compartments and selector genes, 378 Regional patterning of the wing disc, 381 Regeneration and transdetermination, 384 Morphogen gradients and polarity, 387 Section 4: Growth, evolution, regeneration, 391 20 Tissue organization and stem cells, 393 Types of tissue, 393 Tissue renewal, 397 Stem cells, 401 Intestinal epithelium, 403 Epidermis, 408 Hair follicles, 410 Hematopoietic system, 415 Mesenchymal stem cells and “transdifferentiation”, 419 Spermatogonia, 419 21 Growth, aging, and cancer, 425 Growth: control of size and proportion, 425 Biochemical pathways of growth control, 426 Growth control in insects, 429 Growth control in mammals, 431 Liver regeneration, 433 Growth in stature, 434 Aging, 436 Cell autonomous processes, 437 The insulin pathway and aging, 438 Caloric restriction, 438 Cancer, 440 Classification of tumors and precursor lesions, 440 Molecular biology of cancer, 442 Cancer stem cells, 443 Cancer progression, 444 Cancer therapy, 445 22 Pluripotent stem cells and their applications, 449 Human embryonic stem cells, 449 Induced pluripotent stem cells, 451 Somatic cell nuclear transfer, 453 Direct reprogramming, 454 Applications of human pluripotent stem cells, 455 Cell transplantation therapy, 457 Cell transplantation therapies using pluripotent stem cells, 459 Transplantation therapy for diabetes, 460 Retinal pigment epithelium, 462 Spinal repair, 463 Cardiomyocytes, 463 Parkinson’s disease, 463 Introduction of new therapies, 465 23 Evolution and development, 469 Macroevolution, 470 Molecular taxonomy, 471 Phylogeny of animals, 472 The fossil record, 473 The primordial animal, 474 Basal animals, 479 What really happened in evolution?, 481 Segmented body plans and Hox genes, 482 Insect wings and legs, 483 Atavisms, 483 Vertebrate limbs, 485 24 Regeneration of missing parts, 491 Types of regeneration, 491 Distribution of regenerative capacity, 491 Planarian regeneration, 492 Insect limb regeneration, 497 Vertebrate limb regeneration, 499 The process of limb regeneration, 499 The source of cells for regeneration, 501 Regeneration of regional pattern, 502 Regeneration: ancestral or adaptive property?, 508 General properties of regeneration, 509 Glossary, 513 Index, 527

Read more less

Book SynopsisBringing this best-selling textbook right up to date, the new edition uniquely integrates the theories and methods that drive the fields of biology, biotechnology and medicine, comprehensively covering both the techniques students will encounter in lab classes and those that underpin current key advances and discoveries. The contents have been updated to include both traditional and cutting-edge techniques most commonly used in current life science research. Emphasis is placed on understanding the theory behind the techniques, as well as analysis of the resulting data. New chapters cover proteomics, genomics, metabolomics, and bioinformatics, as well as data analysis and visualisation. Using accessible language to describe concepts and methods, and with a wealth of new in-text worked examples to challenge students'' understanding, this textbook provides an essential guide to the key techniques used in current bioscience research.Trade Review'After seven editions between 1975 and 2010 this essential textbook has undergone a major update. The new editors, Drs Hofmann and Clokie, recruited many experts to revise individual chapters and added a significant amount of new material, thus making the book even more valuable. This eighth edition is basically a new book that covers the techniques of biochemistry and molecular biology in a very comprehensive manner - it does not go into great detail, but gives the reader a good introduction to all of them. Each chapter contains suggestions for further reading for those in need of a follow-up. Excellent diagrams and illustrations provide help in comprehension of the presented material. Since this text is largely aimed at undergraduate students, it fulfils its role extremely well.' Alexander Wlodawer, National Cancer Institute at FrederickReview from previous edition: 'This book deserves a place in any modern pathology department and brings together a body of information which is traditionally scattered across several texts … it also represents excellent value for money.' Annals of Clinical BiochemistryReview from previous edition: 'It is necessary to have a practical up to date guide to experimental techniques at hand in a laboratory. This book belongs to such kind of texts. It covers all branches of basic as well as advanced techniques. The book represents a fundamental guidebook for work in a laboratory.' PhotosyntheticaReview from previous edition: 'The book is well illustrated, indexed, free of errors and most chapters have problem sets with worked answers. The book is written for 'all bioscience undergraduate students and pre-medical students for whom practical biochemistry, molecular biology and immunology form part of the syllabus' … it is a very good supplement for undergraduate courses in general biochemistry or a text for courses in biochemical techniques. [This book] is also recommended for graduate students and other researchers in applied sciences such as food biochemistry.' Journal of Food BiochemistryReview from previous edition: '… well-written and comprehensive … what truly distinguishes this text from others of its kind are the outstanding chapters on proteins, mass spectrometry and spectroscopic techniques. … a valuable resource for undergraduate or graduate students taking introductory or advanced techniques/laboratory courses in cell/molecular biology, biochemistry or biotechnology.' Microbiology TodayReview from previous edition: 'I found this volume remarkably satisfying in that it answered all those 'why do you do it like this?' type questions. … This book has already received extensive reference value on my bookshelf.' Journal of Biological EducationTable of ContentsForeword Keith Wilson and John Walker; Preface Samuel Clokie and Andreas Hofmann; Tables and resources Andreas Hofmann; 1. Life science studies Samuel Clokie and Andreas Hofmann; 2. Basic principles Parisa Amani and Andreas Hofmann; 3. Cell culture techniques Anwar Baydoun; 4. Recombinant DNA techniques and molecular cloning Ralph Rapley; 5. Preparative biochemistry Samuel Clokie; 6. Electrophoresis Ralph Rapley; 7. Immunochemical techniques Katja Fischer; 8. Flow cytometry John Grainger and Joanne Konkel; 9. Radioisotope techniques Robert Slater; 10. Clinical biochemistry Gillian Rumsby; 11. Microscopy Stephen Paddock; 12. Centrifugation Kay Ohlendieck and Stephen Harding; 13. Spectroscopic techniques Anne Simon and Andreas Hofmann; 14. Basic techniques probing molecular structure and interactions Anne Simon and Joanne Macdonald; 15. Mass spectrometric techniques Sonja Hess and James MacRae; 16. Fundamentals of bioinformatics Cinzia Cantacessi and Anna Protasio; 17. Fundamentals of cheminformatics Paul Taylor; 18. The Python programming language Timothy Stevens; 19. Processing and visualisation of experimental data Jean-Baptiste Cazier; 20. Fundamental genome sequencing and annotation Pasi Korhonen and Robin Gasser; 21. Fundamentals of proteomics Sonja Hess and Michael Weiss; 22. Fundamentals of metabolomics James MacRae; 23. Enzymes and receptors Megan Cross and Andreas Hofmann; 24. Drug discovery and development David Camp.

Read more less

Book SynopsisPrefaceIAppendix I - Basic Statistical Concepts for Sensory EvaluationIIAppendix A II- Nonparametric and Binomial-based Statistical MethodsIIIStatistical Appendix III- Analysis of Variance IVAppendix IV- Correlation, Regression and Measures of associationVAppendix V - Statistical Power and Test Sensitivity1Chapter 12Physiological and Psychological Foundations of Sensory Function3Principles of Good Practice4Discrimination Testing5Similarity, Equivalence Testing and Discrimination Theory6Measurement of Sensory Thresholds7Scaling8Time-intensity Methods9Context Effects and Biases in Sensory Judgment10Descriptive Judgment 11Texture Evalution12Color and Appearance 13Preference Testing14Acceptance Testing15Consumer Field Tests and Questionnaire Design16Qualitative Consumer Research Methods17Quality Control and Shelf-life (Stability) Testing18Data relationships and multivariate applications19Strategic ResearchTables A-QTrade ReviewFrom the reviews of the second edition:“This volume is an academic text, bringing together theory, methodologies and analysis techniques of sensory evaluation and references to thousands of research articles on sensory science in a logical and practical manner. … its primary aim is as a textbook for university-level sensory science modules. … also serves as an over-arching technical manual and resource for practicing food and drink technologists and sensory scientists. … The book is essential reading for those in the sensory evaluation sphere and serves as an excellent and practical reference.” (Patricia Stefanowicz, Journal of Wine Research, Vol. 24 (1), 2013)Table of ContentsPreface I Appendix I - Basic Statistical Concepts for Sensory Evaluation II Appendix A II- Nonparametric and Binomial-based Statistical Methods III Statistical Appendix III- Analysis of Variance IV Appendix IV- Correlation, Regression and Measures of association V Appendix V - Statistical Power and Test Sensitivity 1 Chapter 1 2 Physiological and Psychological Foundations of Sensory Function 3 Principles of Good Practice 4 Discrimination Testing 5 Similarity, Equivalence Testing and Discrimination Theory 6 Measurement of Sensory Thresholds 7 Scaling 8 Time-intensity Methods 9 Context Effects and Biases in Sensory Judgment 10 Descriptive Judgment 11 Texture Evalution 12 Color and Appearance 13 Preference Testing 14 Acceptance Testing 15 Consumer Field Tests and Questionnaire Design 16 Qualitative Consumer Research Methods 17 Quality Control and Shelf-life (Stability) Testing 18 Data relationships and multivariate applications 19 Strategic Research Tables A-Q

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

Book SynopsisThe aim this volume is to present the methods, challenges, software, and applications of this widespread and yet still evolving and maturing field. Computational Protein Design, the first book with this title, guides readers through computational protein design approaches, software and tailored solutions to specific case-study targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Protein Design aims to ensure successful results in the further study of this vital field.Table of ContentsPart I: Computational Protein Design1. The Framework of Computational Protein DesignIlan Samish2. Achievements and Challenges in Computational Protein DesignIlan Samish3. Production of Computationally Designed Small Soluble- and Membrane-Proteins: Cloning, Expression and PurificationBarsha Tripathy and Rudresh Acharya4. Deterministic Search methods for Computational Protein DesignSeydou Traoré, David Allouche, Isabelle André Thomas Schiex, and Sophie Barbe5. Geometric Potentials for Computational Protein Sequence DesignJie Li and Patrice Koehl 6. Modeling Binding Affinity of Pathological Mutations for Computational Protein DesignMiguel Romero-Durana, Chiara Pallara, Fabian Glaser, and Juan Fernández-Recio7. Multistate Computational Protein Design with Backbone EnsemblesJames A. Davey and Roberto A. Chica8. Integration of Molecular Dynamics Based Predictions into the Optimization of de novo Protein Designs: Limitations and BenefitsHenrique F. Carvalho, Arménio J. M. Barbosa, Ana C. A. Roque, Olga Iranzo, and Ricardo J. F. Branco9. Applications of Normal Mode Analysis Methods in Computational Protein DesignVincent Frappier, Matthieu Chartier, and Rafael NajmanovichPart II: Software of Computational Protein Design Applications10. Computational Protein Design Under a Given backbone Structure with a Statistical Energy FunctionPeng Xiong, Quan Chen, and Haiyan Liu11. Computational Protein Design Through Grafting and StabilizationCheng Zhu, David D. Mowrey, and Nikolay V. Dokholyan12. An Evolution Based Approach to de novo Protein DesignJeffrey R. Brender, David Shultis, Naureen Aslam, and Yang Zhang13. Parallel Computational Protein Design Yichao Zhou, Bruce R. Donald, and Jianyang Zeng14. BindML/BindML+: Detecting Protein-Protein Interaction Interface Propensity from Amino Acid Substitution PatternsQing Wei, David La, and Daisuke Kihara15. OSPREY Predicts Resistance Mutations using Positive and Negative Computational Protein DesignAdegoke Ojewole, Anna Lowegard, Pablo Gainza, Stephanie M. Reeve, Ivelin Georgiev, Amy C. Anderson, and Bruce R. DonaldPart III: Computational Protein Design of Specific Targets16. Evolution-inspired Computational Design of Symmetric ProteinsArnout R.D. Voet, David Simoncini, Jeremy R.H. Tame, and Kam Y. J. Zhang17. A Protocol for the Design of Protein and Peptide Nanostructure Self-assemblies Exploiting Synthetic Amino Acids18. Probing Oligomerized Conformations of Defensin in the MembraneWenxun Gan, Dina Schneidman, Ning Zhang, Buyong Ma, and Ruth Nussinov19. Computational Design of Ligand Binding ProteinsChristine E. Tinberg and Sagar D. Khare20. EpiSweep: Computationally-driven Reengineering of Therapeutic Proteins to Reduce Immunogenicity while Maintaining FunctionYoonjoo Choi, Deeptak Verma, Karl E. Griswold, and Chris Bailey-Kellogg21. Computational Tools for Aiding Rational Antibody DesignKonrad Krawczyk, James Dunbar, and Charlotte M Deane22. Computational Design of Membrane Curvature-Sensing PeptidesArmando Jerome de Jesus and Hang Yin23. Computational Tools for Allosteric Drug Discovery: Site Identification and Focus Library DesignWenkang Huang, Ruth Nussinov, and Jian Zhang

Read more less

Book SynopsisThe application of biocatalysis in organic synthesis is rapidly gaining popularity amongst chemists. Compared to traditional synthetic methodologies biocatalysis offers a number of advantages in terms of enhanced selectivity (chemo-, regio-, stereo-), reduced environmental impact and lower cost of starting materials. Together these advantages can contribute to more sustainable manufacturing processes across a wide range of industries ranging from pharmaceuticals to biofuels. The biocatalytic toolbox has expanded significantly in the past five years and given the current rate of development of new engineered biocatalysts it is likely that the number of available biocatalysts will double in the next few years. This textbook gives a comprehensive overview of the current biocatalytic toolbox and also establishes new guidelines or rules for “biocatalytic retrosynthesis”. Retrosynthesis is a well known and commonly used technique whereby organic chemists start with the structure of their target molecule and generate potential starting materials and intermediates through a series of retrosynthetic disconnections. These disconnections are then used to devise a forward synthesis, in this case using biocatalytic transformations in some of the key steps. Target molecules are disconnected with consideration for applying biocatalysts, as well as chemical reagents and chemocatalysts, in the forward synthesis direction. Using this textbook, students will be able to place biocatalysis within the context of other synthetic transformations that they have learned earlier in their studies. This additional awareness of biocatalysis will equip students for the modern world of organic synthesis where biocatalysts play an increasingly important role. In addition to guidelines for identifying where biocatalysts can be applied in organic synthesis, this textbook also provides examples of current applications of biocatalysis using worked examples and case studies. Tutorials enable the reader to practice disconnecting target molecules to find the ‘hidden’ biocatalytic reactions which can be applied in the synthetic direction. The book contains a complete description of the current biocatalyst classes that are available for use and also suggests areas where new enzymes are likely to be developed in the next few years. This textbook is an essential resource for lecturers and students studying synthetic organic chemistry. It also serves as a handy reference for practicing chemists who wish to embed biocatalysis into their synthetic toolbox.Table of ContentsIntroduction and Aims of the Book; Biocatalysis Basics and Principles; Hydrolysis; Reverse Hydrolysis: Reduction; Oxidation; C–X Bond Formation; C–C Bond Formation, Miscellaneous Biocatalysts; Biocatalytic Disconnections and Functional Group Interconversions; Comparison of Different Biocatalytic Routes to Target Molecules; Applications of Biocatalytic Retrosynthesis

Read more less

Book SynopsisThe effects of inadequate diets on the population include malnutrition, non-communicable diseases and obesity. 'Hidden hunger', also known as micronutrient deficiencies, leads to various health-related disorders and diseases. Indigenous plants, in the form of indigenous fruits and leafy vegetables are gaining interest as a source of nutrients and bioactive phytochemicals, satisfying both food demand and health needs. Moreover, with the impact of climate change, and the importance of sustainability of food systems, it is essential that we investigate new, forgotten and alternative crops that can thrive in harsh conditions, require low fertilizer input, and are easily harvestable.This book contains chapters on 33 understudied indigenous fruits and vegetables from all around the world, including African nightshade, amaranth, baobab fruit, Indian gooseberry, red bush apple and snake melon. Each chapter provides:An overview of plant botany.An understanding of the phytonutrient constituents and health-promoting properties of bioactive compounds or metabolites.Information on the biological activity of the functional compounds that will improve productivity and increase utilization of indigenous fruits and vegetables to sustain food security.Impacts of postharvest storage, processing, and traditional food preparation methods.Potential for new product development.This is an essential resource for academic researchers and industry professionals in the fields of horticulture, agriculture, crop science, human health and nutrition.

Read more less

Book Synopsis'My concern is not to persuade people that they should stop eating. My hope is that they will begin to change their way of thinking, including the way they think about eating and drinking' - Michael Werner. In 1923, Therese Neumann, a nun in Southern Germany, stopped eating and drinking. Apart from the wafer given at Mass, she did not eat again, despite living for a further 35 years. Other similar cases have been reported over the years - often holy men from the East - and have taken on something of a mythical status. However, they remain obscure enough to be brushed aside by modern scientists. Michael Werner presents a new type of challenge to sceptics. A fit family man in his 50s, he has a doctorate in Chemistry and is the managing director of a research institute in Switzerland. In this remarkable account he describes how he stopped eating in 2001 and has survived perfectly well without food ever since. In fact, he claims never to have felt better! Unlike the people who have achieved this feat in the past, he is an ordinary man who lives a full and active life. Michael Werner has an open challenge to all scientists: 'Test me using all the scientific monitoring and data you wish!' In fact, he describes one such test here in which he was kept without food in a strictly monitored environment for ten days. Werner also describes in detail how and why he came to give up food, and what his life is like without it. This book features other reports from those who have attempted to follow this way of life, as well as supplementary material on possible scientific explanations of how one could 'live on light'.Trade Review'[What] can only be ignored with difficulty is the phenomenon itself, for it is crying out to be noticed. One wonders why mainstream science has paid so little attention to it...' - Harald Walach, Research Professor of Psychology, University of Northampton, and Director of the European Office of the Samueli Institute 'What Michael Werner wants is to demonstrate that the generally held view of the world being solely physical and solid cannot be the whole story' - Neue Luzerner Zeitung

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

Book SynopsisWarum brauchen wir Schlaf? Wie entsteht Durst? Oder ein Herzinfarkt? In der Physiologie lernen Sie alles über die Funktionen des menschlichen Körpers. Die 32. Auflage der Physiologie des Menschen wurde komplett überarbeitet, der Stoff ist nun in 84 übersichtliche Kapitel gegliedert. Gleich die erste Seite eines Kapitels bietet einen hervorragenden Überblick über den Lernstoff: In einer Box wird kurz und knapp erklärt, worum es im Kapitel geht. Danach kommen die visuellen Lerner auf ihre Kosten: eine zusammenfassende Abbildung bringt das Wesentliche auf den Punkt. Beim Lernen und Wiederholen unterstützen Sie außerdem: Grüne Zwischenüberschriften – fassen die einzelnen Abschnitte in einem Satz zusammen, ideal zum Wiederholen! Rote Merksätze – machen auf besonders wichtige Inhalte aufmerksam Zusammenfassungen zu allen Abschnitten Fast 200 Klinikboxen – machen die klinischen Bezüge deutlich Über 1000 Abbildungen für das visuelle Lernen Interessante Hintergrundinformationen als Kleingedrucktes Nicht nur für die Vorklinik, auch im klinischen Abschnitt sind die physiologischen Zusammenhänge Grundlage, um Krankheiten und ihre Entstehung zu verstehen. Machen Sie den Brandes/Lang/Schmidt zu Ihrem Begleiter durch das gesamte Studium!Table of ContentsI. Allgemeine Grundlagen.- II. Nervenzelle und Umgebung.- III. Erregungsübertragung von Zelle zu Zelle.- IV. Muskel.- V. Herz.- VI. Kreislauf.- VII. Blut und Immunabwehr.- VIII. Lunge.- IX. Niere.- X. Magen-Darm-Trakt.- XI. Energie und Leistung.- XII. Neuronale Kontrolle von Haltung und Bewegung.- XIII. Allgemeine Sinnesphysiologie und somatosensorisches System.- XIV. Hören, Sprechen und Gleichgewicht.- XV. Sehen.- XVI. Riechen und Schmecken.- XVII. Höhere zentralnervöse Funktionen.- XVIII. Neuroendokrines System.- XIX. Lebenszyklus.

Read more less

Book SynopsisThe focus of this textbook is on application, rather than pure knowledge transfer of the results of all chemical biological work (which would also be beyond the scope of a book). It gives the reader, through the specific selection of chemical biological techniques and concepts, the necessary tools to be able to develop new ways of thinking and thus new therapeutic options in the complex field of chemical biology and drug development. The stated aim of this book is to provide concrete solutions and inspiration to students, (post)graduate students, and experienced scientists at universities as well as in industry in their problems. After an introduction to the problems addressed by chemical biology in drug discovery, the three levels of molecular biology dogma: DNA, RNA and proteins and their role as drug targets serve as the common thread of this book.This book is a translation of the original German 1st edition Chemische Biologie by Marco F. Schmidt, published by Springer-Verlag GmbH Germany, part of Springer Nature in 2020. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors.Table of ContentsForeword.- Introduction.- Part I: Chemical Biology and Drug Development.- Chemical Biology - a Holistic Science.- Drug Development.- From Genomics to Chemical Biology.- Part II: DNA.- DNA - blueprint of proteins.- Genomic Variation.- Gene Therapy and Genome Editing.- Part III: RNA.- RNA - information and function carrier.- RNA Interference in Drug Development.- Part IV: Proteins.- Peptides & proteins.- Proteins as drug targets.- Chemical genomics - From target protein to drug.- From target protein to macromolecular drug - Biologics.- Chemical proteomics: From drug to target protein.- Chemical genetics: validation of drug target by elucidation of signaling pathway.- Chemical biology - Addressing new drug targets.

Read more less

Book SynopsisThis definitive volume will provide the reader with up to date information and the most recent science of the fast-evolving area of nanobiotherapeutic-based blood substitutes. Long studied, there are recent updates that make their use in patients more promising, and with one product approved for human use, many more in the pipeline. These include 2nd generations and even third generation ones, the later with enhancement of red blood cell functions. In addition, there are carefully written and referenced updates on the recent history and products in the field, complete with pathophysiologic and pharmacologic studies to validate and verify the efficacy and safety of many of these new products.Table of ContentsUnlimited Potential of Nanobiotechnology Based Blood Substitutes, Artificial Cells and Nanobiotherapeutics (TMS Chang); General: Development and Future of Chinese Transfusion Medicine and Blood Substitutes (J Liu and C Yang); The Clinical Impact of Red Blood Cell Storage: What Have the RCTs Told Us? (CP Stowell); Rational, Evidence-Based Transfusion: A Physiologist's Perspective (GP Biro); Hemoglobin-based Oxygen Carriers, Volume Expansion, Fluid Management and Anemia (TN Estep); Hemoglobin-Based Oxygen Carriers: Biotechnology-based Oxygen Carriers (TMS Chang); Hemoglobin-Glutamer 250 (bovine) [HBOC-201, Hemopure (R)] Clinical Use in South Africa and Comprehensive Review of Cardiac Outcomes and Risk/Benefit in Peer-Reviewed, Indexed Studies in Humans and Animal Models (JS Jahr, K Tseng, AP Brown and GP Dube); Immune Safety Evaluation of Polymerized Porcine Hemoglobin (pPolyHb) - Potential Red Blood Cell Substitutes (H Zhu, K Yan, X Dang, H Huang, E Chen, B Chen, Chan Luo, TMS Chang, P Dai and C Chen); Hemoglobin-Based Oxygen Carriers and Inhaled Nitric Oxide (B Yu and WM Zapol); Hemoglobin-Based Oxygen Carriers and Myocardial Infarction: Assessment of Potential Mechanisms (TN Estep); Insights Into the Possible Mechanisms of Hemoglobin-based Oxygen Carrier-Mediated Bradycardia and Adverse Cardiac Effects Observed in Clinical Trials (HW Kim); Modulation of Oxygen Affinity in Hemoglobin-based Oxygen Carriers (EAM Alomari, L Ronda, S Bettati, A Mozzarelli and S Bruno ); Cysteine Mutations in Recombinant Fetal Hemoglobin Influence Oxidative Side-Reactions (K Kettisen and L Bulow); Analysis of Dimeric A Subunit Exchange between Bis-PEGylated and Native Hemoglobins (T Matsuhira, K Yamamoto and H Sakai); Ring-Opening Polymerization of Hemoglobin Based on Supramolecular Chemistry (T Matsuhira, K Yamamoto and H Sakai); Hemoglobin-Based Oxygen Carriers with Antioxidant Activities: Unraveling of Hemoglobin Oxidative Toxicity: Thirty Years of Investigation (AI Alayash ); A Nanobiotechnologic Therapeutic that Transport Oxygen and Removes Oxygen Radicals (TMS Chang); Effects of Crosslinked Polyhemoglobin-Superoxide Dismutase-Catalase on Blood-Brain Barrier and Brain Edema in a Hemorrhagic Shock Transient Global Ischemia Rat Model (DD Powanda and TMS Chang); Strategies to Decrease the Oxidative Toxicity of Hemoglobin-Based Oxygen Carriers (L Zhoa); Enhancing the Stability of Lumbricus terrestris Erythrocruorin (LtEc) for Use as a Blood Substitute (B Timm and J Elmer); Dual Antioxidant and Pro-Oxidation Effects of Ascorbic Acid on Bovine Hemoglobin (G Chan and TMS Chang); Hemoglobin-Based Oxygen Carriers with Enhancement in Both Antioxidant Functions and Carbon Dioxide Transport: Soluble Nanobiotherapeutics with Enhancements of All Three Major Red Blood Cell Functions (TMS Chang); A Novel Nanobiotherapeutical Poly-[Hemoglobin-Superoxide Dismutase-Catalase-Carbonic Anhydrase] with No Cardiac Toxicity for the Resuscitation of a 90-minute Sustained Severe Hemorrhagic Shock Rat Model with Two-third Blood Volume Loss (Y Bian and TMS Chang); Long Term Safety and Immunological Effects of a Nanobiotherapeutic, Bovine Poly-[Hemoglobin-Catalase-Superoxide Dismutase-Carbonic Anhydrase], After Four Weekly 5% Blood Volume Toploading Followed by a Challenge of 30% Exchange Transfusion (G Chen and TMS Chang); Extraction of Superoxide Dismutase, Catalase and Carbonic Anhydrase from Stroma-free Red Blood Cell Hemolysate for the Preparation of the Nanobiotechnological Complex of PolyHemoglobin-superoxide Dismutase-Catalase-Carbonic anhydrase (C Guo, M Gynn and TMS Chang); Temperature Stability of Poly-[hemoglobin-superoxide Dismutase-Catalase-Carbonic anhydrase] in the Form of a Solution or In the Lyophilized Form During Storage at -80 DegreesC, 4 DegreesC, 25 DegreesC and 37 DegreesC or Pasteurization at 70 DegreesC (Y Bian, C Guo and TMS Chang); Biodegradable and Lipid Membrane Nanoencapsulated Nano-Artificial Cells: Nanotechnology-based Complete Artificial Red Blood Cells (TMS Chang ); Analysis of Polyethylene-Glycol-Polylactide Nano-Dimension Artificial Red Blood Cells in Maintaining Systemic Hemoglobin Levels and Prevention of Methemoglobin Formation (TMS Chang, DD Powanda D and WP Yu); Effects of PEG-PLA-Nano Artificial Cells Containing Hemoglobin on Kidney Function and Renal Histology in Rats (ZC Liu and TMS Chang); Long Term Effects on the Histology and Function of Livers And Spleens in Rats after 33% Toploading of PEG-PLA Nano-Artificial Red Blood Cells (ZC Liu and TMS Chang); Polylactide-Polyethylene Membrane Nanoencapsulated Polyhemoglobin-superoxide Dismutase-Catalase-Carbonic anhydrase. Nano-Artificial Red Blood Cells that Act as O2 and CO2 Carriers with Enhanced Antioxidant Activity (W Gao, Y Bian and TMS Chang); Possibility of Pre-Hospital Resuscitation using Hemoglobin Vesicles for Trauma Hemorrhagic Shock with Coagulopathy - Our Resuscitation Strategy (M Kinoshita and K Hagisawa); Translational Research of Hemoglobin Vesicles (Artificial Red Cells) for a Transfusion Alternative and O2/CO Therapeutics (H Sakai, H Azuma, H Horinouchi and K Kobayashi); Hemoglobin Vesicles as a Transfusion Alternative for Perioperative Hemorrhage in Thoracic Surgery (M Kohno, R Hashimoto, H Onozawa, K Oiwa, H Horinouchi, H Sakai, K Kobayashi and M Iwazaki); Prevention of Methemoglobin Formation in Artificial Red Cells (Hemoglobin-Vesicles) (H Sakai and M Yamada); Carbon Monoxide-Bound Hemoglobin-Vesicles: Current Facts and Potential Medical Applications (K Taguchi, K Matsumoto, H Sakai, T Maruyama and M Otagiri); Influence of Hemoglobin Vesicles on Immune Function (H Azuma, M Fujihara and H Sakai); Cells, Tissues and Organs Preservation: Development of a New HBOC for Liver Allograft Preservation in Combination with Machine Perfusion - Clearing the Wait List (KD Vandegriff, A Malavalli and WR Light); OxyVita (R) Hb: A Step Forward in Delivering Oxygen Carrying Capacity for Therapeutic Applications (H Wollocko, J Harrington, JS Jahr, K Steier and J Wollocko); Functionality of Albumin-Derived Perfluorocarbon-Based Artificial Oxygen Carriers in the Langendorff Heart (KB Ferenz and M Kirsch); Nanobiotherapeutics as Preservation Fluids for Organs and Cells (TMS Chang, W Jiang, F D'Agnillo and S Razack ); Platelet: Polyhemoglobin-Fibrinogen: A Novel Oxygen Carrier with Platelet-like Properties in a Hemodilution Setting (NSW Wong and TMS Chang); Megakaryocytes and Platelets from Novel Human Adipose Tissue-Derived Mesenchymal Stem Cells: Development of Cell-based Regenerative Medicine (Y Ono-Uruga, K Tozawa, Y Ikeda and Y Matsubara);

Read more less

Book SynopsisThis book presents fundamental and practical information on food chemistry. Using 2-D barcodes, it illustrates the specific reactions and potential transformation mechanisms of food constituents during various manufacturing and storage processes, and each chapter features teaching activities, such as questions and answers, and discussions. Further, it describes various local practices and improvements in Asia. Divided into 12 chapters covering individual nutrients and components, including water, proteins, carbohydrates, lipids, vitamins, minerals, enzymes, pigments, flavoring substances, additives, and harmful constituents, it addresses their food chemistry, as well as their transformations during manufacturing processes, and typical or advanced treatments to improve food quality and safety. This book helps college students to gain a basic understanding of nutrients and food components, to discover and implement the practical industrial guidelines, and also to learn the latest developments in food chemistry.Table of ContentsIntroduction.Water.- Proteins.- Carbohydrates.- Lipids.- Vitamins.- Minerals.- Enzyme.- Pigments.- Food Flavor Substances.- Food additives.- Harmful Constituents.

Read more less

Book SynopsisBiochemistry is a major new textbook designed and created specifically for briefer courses in the subject. Written by Prof. Terry Brown of the University of Manchester (author of Genomes and Gene Cloning), the book provides the necessary detail and rigour expected for these courses, but without the extraneous material found in the larger textbooks. With an increasing number of students taking a short course in biochemistry there is a growing need for a book that covers the subject concisely and succinctly. Biochemistry has been designed from the outset for these shorter courses; it is not a cut-down version of one of the larger books that dominate the market. Although it is shorter, there is no compromise in content, style and coverage. The book is attractively designed in full colour throughout with all the pedagogical features expected in a major textbook. It covers what students should be expected to know and is written in the clear and accurate writing style for which Terry Brown is widely lauded. With its competitive price and resources for adopting lecturers (all of the illustrations and diagrams from the book, and answers to the end of chapter questions), Biochemistry will become the textbook of choice for any brief biochemistry course. Confirmed Adoptions Biochemistry is already the required text at the following institutions: Becker College, USA Bishop Burton College, UK Bournemouth University, UK Charles R. Drew University of Medicine and Science, USA Charleston Southern University, USA Colorado State University - Pueblo, USA Idaho State University, USA Liverpool John Moores University, UK Montclair State University, USA Newcastle University, UK Rivier University, USA Southeast Missouri State University, USA Staffordshire University, UK Stephen F Austin State University, USA Texas Christian University, USA The University of Texas at Austin, USA Umeå University, Sweden University of Aberdeen, UK University of Bradford, UK University of Bedfordshire, UK University of Brighton, UK University of the Incarnate Word, USA University of Kansas, USA University of Miami Miller School of Medicine, USA University of Nottingham, UK University of Roehampton, UK University of Salford, UK University of the West of England, UK University of Tulsa, USA Valley City State University, USA Yale University School of Medicine, USATrade ReviewFive-star reviews: Helpful, informative, and cheap too!"This is one of the recommended textbooks for the first year of my course. It is very easy to read, and finding the information that I need is also very simple. The illustrations are great, as they are easy to follow whilst also including all of the important knowledge. This book is also pretty cheap, which is amazing considering that I've used this book a lot more than the other more expensive recommended texts!" Very nice book "This is a very nice, well-written book with lots of illustrations. I highly recommend it for biomedical science degrees." All the pretty pictures! "I love the content in this book. There's lots of colorful pictures and different side stories that relate to the content of each section. I sound like a child, but I can't stress enough how helpful colorful pretty pages are for me when it comes to information retention. The book presents the chemistry aspect of the content in easy little squares/boxes of information. Just relevant details without drowning you. I am a chemistry major, but's definetly refreshing to read such a friendly book. Did I mention how easy it is to read? It is. You could sit down at the laundromat while all of your 3 pairs of pants and 4 shirts wash, and read this book like a novel." -- Amazon reviewersTable of ContentsChapter 1 Biochemistry in the modern world PART I CELLS, ORGANISMS AND BIOMOLECULES Chapter 2 Cells and Organisms Chapter 3 Proteins Chapter 4 Nucleic acids Chapter 5 Lipids and biological membranes Chapter 6 Carbohydrates PART II ENERGY GENERATION AND METABOLISM Chapter 7 Enzymes Chapter 8 Energy generation: glycolysis Chapter 9 Energy generation: the TCA cycle and electron transport chain Chapter 10 Photosynthesis Chapter 11 Carbohydrate metabolism Chapter 12 Lipid metabolism Chapter 13 Nitrogen metabolism PART III STORAGE OF BIOLOGICAL INFORMATION AND SYNTHESIS OF PROTEINS Chapter 14 DNA replication and repair Chapter 15 RNA synthesis Chapter 16 Protein synthesis Chapter 17 Control of gene expression PART IV STUDYING BIOMOLECULES Chapter 18 Studying proteins, lipids and carbohydrates Chapter 19 Studying DNA and RNA

Read more less

Book SynopsisTable of Contents Section 1 Methodological foundations of health research 1 Foundations of health research 2 Quantitative and qualitative methods 3 The research process Section 2 Research planning 4 The formulation of research questions 5 Sampling methods and external validity 6 Ethics Section 3 Research designs 7 Experimental designs and randomized controlled trials 8 Surveys and quasi-experimental designs 9 Qualitative research Section 4 Data collection 10 Questionnaires and survey design 11 Mixed methods 12 Interviewing techniques 13 Measurement and observation Section 5 Descriptive statistics 14 Organization and presentation of data 15 Measures of central tendency and variability 16 Standard scores and normal distributions 17 Correlation Section 6 Data analysis and inference 18 Probability and confidence intervals 19 Hypothesis testing: selection and use of statistical tests 20 Effect size and the interpretation of evidence 21 Qualitative data analysis 22 Critical evaluation of published research Section 7 Evaluation and dissemination of research results 23 Synthesis of research evidence: systematic reviews and meta-analyses 24 Translational research

Read more less

Book SynopsisArguing for the primacy of the material arrangements of the laboratory in the dynamics of modern molecular biology, the author develops a new epistemology of experimentation in which research is treated as a process for producing epistemic things.Trade Review“This is one of the most profound works in the history and philosophy of science in decades. One seldom encounters works of such depth and originality; its conceptual framework and analytical tools are truly pathbreaking. The literary style of the work is inspiring in its poetic qualities, and the blend of wit, playfulness, rigor, and succinctness makes for captivating reading.”—Lily E. Kay, Massachusetts Institute of TechnologyTable of ContentsContents 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13.

Read more less

Book SynopsisProlog.- CONDITIONS NECESSARY FOR LIFE: TAKE MINERALS, WATER, OXYGEN AND STIR.-WHAT ARE THESE THINGS DOING IN MY BODY? OVERVIEW OF LIVING CELLS.-OUR SUPERBEES: HOW FAST ARE ENZYMES?.-WHAT ARE THESE THINGS DOING IN MY BODY? OVERVIEW OF LIVING CELLS.-HOW DID WE GET HERE? STARTING CONDITIONS FOR LIFE ON EARTH.-THE NUTS AND BOLTS OF METABOLISM: HOW CELLS FUNCTION.-THE ABC’S OF PROTEINS STRUCTURE AND SYNTHESIS.-OUR AMAZING HEMOGLOBIN: BLOOD AND THE CIRCULATORY SYSTEM.-ALLOSTERIC ENZYMES: SHAPE SHIFTERS.-SEX AND NUCLEIC ACID ENZYMES.-UH, OH MY GENES ARE CHANGING: EVOLUTION AND DISEASES.-CONTROL YOUR SUGAR: SPECIAL ENZYMES CONTROL GLUCOSE METABOLISM.-ENEMIES WITHIN? OUR OWN ENZYMES HELP VIRUSES TO INFECT US.-TRAITORS: CANCER RESULTS WHEN REGULATORY PROTEINS BECOME MUTATED.-Epilog.-INDEX.

Read more less

Book SynopsisDespite competition from an ever-growing range of alternative adult beverages, beer remains a vastly important beverage globally. There is a huge diversity of beer styles, drinks suited not only to refreshment and delight in themselves, but also to suit any drinking occasion, including alongside food of all types. There is nutritional value in beer and evidence that, consumed responsibly, it can be a valuable part of a well-balanced diet. This relates to the wholesomeness of the basic materials employed for the brewing of beer, notably malt and hops, but also the nature of the longstanding processes that are employed in converting cereals such as barley and wheat into malt and thence through the time-honored stages of brewing. This book explains these issues- history, nature and complexity of the modern brewing business, types of beer, quality attributes of beer, the underpinning processes, and much more. Any reader, from those who know little about the subject through to the beer aficTrade ReviewThis book is a good read for anyone interested in the science of beer or its consumption." -Chemistry WorldTable of ContentsForeword by Dr Tim Cooper Preface Preface to the Third Edition Preface to the Second Edition Preface to the First Edition Acknowledgments Introduction Chapter 1: FERTILE CRESCENT TO FRANKFURT: The World of Beer and Breweries Chapter 2: A BRIEF HISTORY OF BEER Chapter 3: BARLEY TO BARREL: The Basics of Malting and Brewing Chapter 4: PERSONAL CHOICE: Beer Styles Chapter 5: SEE, SMELL, SAVOR: The Quality of Beer Chapter 6: BEER AND BODY Chapter 7: THE HEART AND SOUL OF BEER: Malt Chapter 8: WATER: And Genuine Terroir Chapter 9: RICE, CORN AND OTHER TOUCHY SUBJECTS Chapter 10: THE WICKED AND PERNICIOUS WEED: Hops Chapter 11: HOT STUFF: The Brewhouse Chapter 12: GODESGOOD: Yeast and Fermentation Chapter 13: REFINING MATTERS: Downstream Processing Chapter 14: ENVIRONMENTAL MATTERS Chapter 15: MEASURE FOR MEASURE: How Beer Is Analyzed Chapter 16: REVERENCE FOR BEER Chapter 17: TO THE FUTURE: Malting and Brewing in Years to Come Glossary Further Study Index

Read more less

Book SynopsisOffers information on basic biochemical and cellular processes in brain function and neurological diseases for continuing medical education and qualifying examinations. This text explores the translational nature of neuroscience. It covers a range of cellular, molecular and medical neuroscience.Table of ContentsPart I: Cellular Neurochemistry and Neural Membranes Cell Biology of the Nervous SystemCell Membrane Structures and FunctionsMembrane TransportElectrical Excitability and Ion Channels Lipids The Cytoskeleton of Neurons and Glia Intracellular Trafficking Axonal Transport Cell Adhesion Molecules Myelin Structure and Biochemistry Energy Metabolism of the Brain PART II: Intercellular Signaling Synaptic Transmission and Cellular Signaling: An Overview Acetylcholine Catecholamines Serotonin Histamine Glutamate and Glutamate ReceptorsGABA Purinergic Signaling Peptides PART III: Intracellular SignalingG Proteins Cyclic Nucleotides in the Nervous System Phosphoinositides Calcium Serine and Threonine Phosphorylation Tyrosine Phosphorylation Transcription Factors in the Central Nervous System PART IV: Growth, Development and Differentiation Development of the Nervous SystemGrowth Factors Stem Cells in the Nervous System Formation and Maintenance of MyelinAxonal Growth in the Adult Mammalian Nervous System PART V: Cell Injury and Inflammation Molecular Mechanisms and Consequences of Immune and Nervous System ReactionsNeuroinflammationBrain Ischemia and Reperfusion: Cellular and Molecular Mechanisms in Stroke InjuryLipid Mediators: Eicosanoids, Docosanoids and Platelet-Activating Factor Apoptosis and Necrosis PART VI: Inherited and Neurodegenerative Diseases Peripheral Neuropathy Diseases Involving Myelin The Epilepsies: Phenotypes and Mechanisms Genetics of Neurodegenerative Diseases Disorders of Amino Acid Metabolism Inborn Metabolic Defects of Lysosomes, Peroxisomes, Carbohydrates, and Fatty Acids and MitochondriaDisorders of Muscle Excitability Motor Neuron Diseases Neurobiology of Alzheimer's Disease Synucleinopathies and Tauopathies Cellular and Molecular Basis of Neurodegeneration in the CAG-Polyglutamine Repeat DiseasesNeurotransmitters and Disorders of the Basal Ganglia Molecular Basis of Prion Diseases PART VII: Sensory Transduction Molecular Biology of Vision Molecular Biology of Olfaction and Taste Molecular Biology of Hearing and Balance Pain PART VIII: Neural Processing and Behavior Endocrine Effects on the Brain and Their Relationship to Behavior Learning and Memory The Neurochemistry of Sleep and WakefulnessThe Neurochemistry of Schizophrenia The Neurochemistry of AutismNeurobiology of Severe Mood and Anxiety Disorders Addiction

Read more less

Book SynopsisBased on the author's academic and industrial experience and backed by a thorough review of the literature, this book provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis.Table of ContentsPeptide Fragmentation/Deletion Premature FMOC Deprotection Elimination Side Reactions Peptide Global Deprotection/Scavenger-Induced Side Reactions Peptide Rearrangement Side Reactions Side Reactions Occurring at Amino Acid/Peptide Activation Step Intramolecular Cyclization Side Reactions Side Reactions in Amino Groups in Peptide Synthesis Side Reactions in Hydroxyl, Carboxyl, Ester Groups in Peptide Synthesis Oxidation and Reduction Side Reactions in Peptide Synthesis Racemization in Peptide Synthesis Solvent and Residual Impurities in the Reagents Induced Side Reactions Dipeptide Formation Side Reactions (Redundant Amino Acid Incorporation) Reattachment of Peptides to the Solid Supports Addition Side Reactions in Peptide Synthesis Side Reactions in Phosphor Peptides Side Reactions in CYS Protein Fragmentations

Read more less

Book SynopsisThis is a very simple but complete description of synchrotron sources and free electron lasers and of the corresponding instrumentation and techniques written primarily for scientists and students in the life sciences, medical research and chemistry. Scientists and students in other fields can also profit from a clear and elementary introduction to this rapidly expanding field. The emphasis is on simple concepts and the mathematical formalism is reduced to a minimum. No advanced knowledge of physics and mathematics is required beyond a standard elementary background.The reading is facilitated by a two-level presentation including a very simple descriptive treatment, and slightly more in-depth discussions of specific topics. With the first-level treatment, the readers will be able to understand the notions, terms, and techniques that are required to use a synchrotron facility. The book is therefore an ideal first step for all those beginning to use synchrotron light for their work or arTrade Reviewa useful and refreshing treatment of synchrotron radiation. * A.M. Glazer, University of Oxford *a unique source of information, * A. Snigirev, ESRF Grenoble *will appeal to all synchrotron radiation users * D.M. Lawson, Biological Chemistry Dept, John Innes Centre, Norwich *Table of Contents1. Smart tourist guide to a synchrotron light facility ; 2. The Facility ; 3. Applications of synchrotron light ; 4. Free electron lasers (FELs) ; 5. Future directions

Read more less

Book SynopsisEssentials of Human Nutrition provides a complete and student-friendly introduction to the field for those embarking on courses in nutrition, or related subjects, for the first time. Written by an international team of experts, every chapter is carefully edited to give consistently clear and coherent explanations of all of the essential principles of nutrition. Key Features BL Chapters cover a broad range of disciplines to help students develop a complete understanding of the subject.BL Inter-chapter links help students see connections between different topics and build up a coherent picture of the subject as a whole.BL The text explains the impact of nutritional principles applied in practice, for example, in the context of sports and health care.New to this EditionThis sixth edition has been updated to incorporate new research and emerging topics such as biomarkers, assessment of nutritional status, and binge-eating disorders. Digital Formats and ResourcesEssentials of Human Nutrition is available for students and institutions to purchase in a variety of formats, and is supported by online resources.BL The e-book offers a mobile experience and convenient access: www.oxfordtextbooks.co.uk/ebooksBL Lecturer resources BL Image bankTrade ReviewReview from previous edition A great introduction to basic nutrition, diet, factors influencing dietary choice, dietary needs through the life course, and a taster of how diet and poor nutrition can be both a cause and a consequence of disease.An essential textbook for any introductory course in nutrition.A comprehensive, well written, and relevant textbook which provides an excellent overview of the current field of human nutrition.Table of ContentsPart 1: Introducing Human Nutrition 1: A. Stewart Truswell, Jim Mann, and Leanne Hodson: Introduction Part 2: Energy and Macronutrients 2: Jim Mann and Andrew Reynolds: Carbohydrates 3: C. Murray Skeaff, Jim Mann, and Leanne Hodson: Lipids 4: Colleen S. Deane, Daniel J. Wilkinson, and Philip J. Atherton: Protein 5: Andrew M. Prentice: Energy 6: A. Stewart Truswell: Alcohol Part 3: Organic and Inorganic Essential Nutrients 7: Lewis J. James and Gethin H. Evans: Water, Electrolytes, and Acid-base Balance 8: Helen Lambert, Ohood Hakim, and Susan A. Lanham-New: Major Minerals: Calcium and Magnesium 9: Patrick MacPhail: Iron 10: Samir Samman, Sheila Skeaff, Christine D. Thomson, and A. Stewart Truswell: Trace Elements 11: David I. Thurnham: Vitamin A and Carotenoids 12: A. Stewart Truswell: The B Vitamins 13: A. Stewart Truswell and Jim Mann: Vitamins C and E 14: A. Stewart Truswell: Vitamins D and K 15: Bernhard Watzl: Other Biologically Active Substances in Plant Foods: Phytochemicals 16: Anne-Marie Minihane: Nutrition, Genetics, and Personalized Nutrition Part 4: Nutrition-Related Disorders 17: Mike Lean: Overweight and Obesity 18: A. Stewart Truswell: Protein-Energy Malnutrition 19: Jim Mann and Rachael McLean: Cardiovascular Diseases 20: Kathryn E. Bradbury and Timothy J. Key: Nutrition and Cancer 21: Jim Mann: Diabetes Mellitus and the Metabolic Syndrome 22: Hannah Turner and Robert Peveler: The Eating Disorders: Anorexia Nervosa, Bulimia Nervosa, Binge-Eating Disorder, and OSFED Part 5: Foods 23: Andrew Reynolds, A. Stewart Truswell, Margaret Allman-Farinelli, Meika Foster, Anna Rangan, Leanne Hodson, and Kim Bell-Anderson: Food Groups 24: Martijn B. Katan: Functional Foods and Health Claims 25: Peter Williams and Paul Brent: Food Toxicity and Safety Part 6: Changing Food Habits 26: A. Stewart Truswell and Helen Leach: Food Habits 27: A. Stewart Truswell, Leanne Hodson, and Jim Mann: Nutritional Recommendations for the General Population 28: Susan A. Jebb: Public Health Approaches to Implement Dietary Recommendations 29: C. Murray Skeaff: Dietary Patterns 30: Wilma Waterlander and Boyd Swinburn: Food Systems: Challenges and Ways Forward 31: Tim Lang and Pamela Mason: Nutrition, the Environment, and Sustainable Diets Part 7: Life Stages 32: Annie S. Anderson: Pre-Pregnancy, Pregnancy, and Lactation 33: Anne-Louise Heath, Helen Crawley, and Rachael Taylor: Infant Feeding and Eating Well for Toddlers 34: Rachael Taylor and Anne-Louise Heath: Childhood and Adolescent Nutrition 35: Sian Robinson and Clare Corish: Nutrition and Ageing Part 8: Nutritional Assessment 36: Philippa Lyons-Wall: Food Analysis, Food Composition Tables, and Databases 37: Jim Mann and Silke Morrison: Dietary Assessment 38: A. Stewart Truswell: Assessment of Nutritional Status 39: Nita G. Forouhi and Albert Koulman: Biomarkers Part 9: Applications 40: Louise M. Burke: Sports Nutrition 41: Claire Smith and Winsome R. Parnell: Nutritional Consequences of Poverty and Food Insecurity in Developed Countries 42: Suzie Ferrie: Food in Hospitals 43: Ross C. Smith: Nutritional Support for Hospital Patients

Read more less

Book SynopsisSection 1: Structure and Biosynthesis of Arabinogalactan-Proteins.- 1. A Brief History of Arabinogalactan-Proteins.- 2. Structural Classes of Arabinogalactan-Proteins.- 3. Molecular Analysis of Genes Encoding Arabinogalactan-Proteins.- 4. The C-Terminal PAC Domain of a Secreted Arabinogalactan-Protein from Carrot Defines a Family of Basic Proline-Rich Proteins.- 5. Structure and Biosynthesis of L-Fucosylated Arabinogalactan-Proteins in Cruciferous Plants.- Section 2: Localization and Action of Arabinogalactan-Proteins at the Subcellular and Cellular Levels.- 6. Characterization and Localization of a Novel Tomato Arabinogalactan-Protein (LeAGP-1) and the Involvement of Arabinogalactan-Proteins in Programmed Cell Death.- 7. Cell Cycle Arrest by Perturbation of Arabinogalactan-Proteins with Yariv Phenylglycoside.- 8. A Major Antimicrobial Hybrid Chitin-Binding Protein from French Bean with Features Common to Arabinogalactan-Proteins and Hydroxyproline-Rich Glycoproteins.- Section 3: Arabinogalactan-Proteins in Somatic Embryogenesis.- 9. Arabinogalactan-Proteins and Cell Development in Roots and Somatic Embryos.- 10. Effect of Arabinogalactan-Proteins and Chitinases on Somatic Embryogenesis.- Section 4: Arabinogalactan-Proteins in Reproductive Development.- 11. Arabinogalactan-Proteins in Reproductive Tissues of Flowering Plants.- 12. Transcriptional, Post-Transcriptional and Post-Translational Regulation of a Nicotiana Stylar Transmitting Tissue-Specific Arabinogalactan-Protein.- 13. Characterization of Arabinogalactan-Proteins and a Related Oligosaccharide in Developing Rice Anthers.- 14. Arabinogalactan-Proteins in Pollen Tube Growth.- Section 5: Arabinogalactan-Proteins in Vegetative Development.- 15. Arabinogalactan-Proteins, Place-Dependent Suppression and Plant Morphogenesis.- 16. Xylem-Specific Expression of Arabinogalactan-Protein-Like Genes.- 17. Induction of Phyletic Phenocopies in Streptocarpus (Gesneriaceae) by Three Antagonists of Hydroxyproline-Protein Synthesis.- 18. Evidence for the Interrelated Actions of Auxin, Ethylene, and Arabinogalactan-Proteins on the Transition from Non-Apical to Apical Growth of Physcomitrella patens Hedw. (Funariaceae).- Section 6: Medically and Industrially Important Arabinogalactan-Proteins and Related Macromolecules.- 19. Bioactive Arabinogalactan-Proteins and Related Pectic Polysaccharides in Sino-Japanese Herbal Medicines.- 20. Uses of Gum Arabic (Acacia sp.) in the Food and Pharmaceutical Industries.- 21. Structural Analysis of Gum from Acacia senegal (Gum Arabic).- 22. Promising Gums from Sources other than Acacia senegal.- 23. Immunochemical, Structural and Functional Properties of Mesquite Gum Compared with Gum Arabic.- Section 7: Short Papers and Abstracts.- Structure of an Arabinogalactan-Protein Glycosylphosphatidylinositol Anchor.- Glycosylphosphatidylinositol Ceramide Lipid Anchor on Rose Arabinogalactan-Proteins.- Characterization of Arabinogalactan-Proteins Secreted by Suspension Cells and Protoplasts of Sugar Beet.- A Proteoglycan from Saffron Corm (Crocus sativus L.) Inhibits Root Elongation of Nicotiana tabacum Seedlings and is Highly Cytotoxic on Tobacco Cells and Protoplasts.- Arabinogalactan-Protein Epitopes Are Host-Derived in Frankia-Alnus Symbiosis.- The Role of Chitinases, Arabinogalactan-Proteins, and Nodulation Factors in the Regulation of Somatic Embryogenesis in Norway Spruce.- The Class III Pistil-Specific Extensin-Like Proteins of Nicotiana tabacum Show Arabinogalactan-Protein-Like Characteristics and are Non-Specifically Translocated Through Pollen Tube Walls InVivo.- Arabinogalactan-Proteins, Pollen Tube Growth and Effect of Yariv Phenylglycoside.- Pollination in Arabidopsis thaliana: Cell-Cell Interaction During Pollen Tube Growth.- Adhesion Molecules in Lily Pollination.- A Role for Arabinogalactan-Proteins in Root Growth.- Cytochemical Analysis of Cell Wall Composition in Non-Articulated Laticifers.- A Glycoconjugate Isolated from the Saffron Plant (Crocus sativus L.) is Cytolytic Against Tumoral Cells and Activates Macrophages In Vitro.- Production of Arabinogalactan-Proteins in Beta vulgaris Cell Suspension Cultures: A Response to Hydrodynamic Stress.- Quantitative and Qualitative Study of Arabinogalactan-Peptide During Bread Making.- The Effect of Larch Arabinogalactan on Mixing Characteristics of Wheat Flour Dough.Trade Review`Overall, this book is an excellent source of information to all scientists interested in AGPs and cell surface components. It provides a basis for further investigations on the involvement of AGPs in plant cell signalling.' Plant Science, 160 (2001)Table of ContentsAbbreviations. Section 1: Structure and Biosynthesis of Arabinogalactan-Proteins. 1. A Brief History of Arabinogalactan-Proteins; B.A. Stone, K. Valenta. 2. Structural Classes of Arabinogalactan-Proteins; A. Bacic, et al. 3. Molecular Analysis of Genes Encoding Arabinogalactan-Proteins; C. Reuzeau, et al. 4. The C-Terminal PAC Domain of a Secreted Arabinogalactan-Protein from Carrot Defines a Family of Basic Proline-Rich Proteins; T.C. Baldwin, et al. 5. Structure and Biosynthesis of L-Fucosylated Arabinogalactan-Proteins in Cruciferous Plants; Y. Hashimoto. Section 2: Localization and Action of Arabinogalactan-Proteins at the Subcellular and Cellular Levels. 6. Characterization and Localization of a Novel Tomato Arabinogalactan-Protein (LeAGP-1) and the Involvement of Arabinogalactan-Proteins in Programmed Cell Death; A.M. Showalter, et al. 7. Cell Cycle Arrest by Perturbation of Arabinogalactan-Proteins with Yariv Phenylglycoside; J.A. Eyvazzadeh, E.A. Nothnagel. 8. A Major Antimicrobial Hybrid Chitin-Binding Protein from French Bean with Features Common to Arabinogalactan-Proteins and Hydroxyproline-Rich Glycoproteins; G.P. Bolwell, et al. Section 3: Arabinogalactan-Proteins in Somatic Embryogenesis. 9. Arabinogalactan-Proteins and Cell Development in Roots and Somatic Embryos; C.G. Steele-King, et al. 10. Effect of Arabinogalactan-Proteins and Chitinases on Somatic Embryogenesis; M. Kreuger, et al. Section 4: Arabinogalactan-Proteins in Reproductive Development. 11. Arabinogalactan-Proteins in Reproductive Tissues of Flowering Plants; A.E. Clarke, et al. 12. Transcriptional, Post-Transcriptional and Post-Translational Regulation of a Nicotiana Stylar Transmitting Tissue-Specific Arabinogalactan-Protein; A.Y. Cheung, et al. 13. Characterization of Arabinogalactan-Proteins and a Related Oligosaccharide in Developing Rice Anthers; K. Kawaguchi, N. Shibuya. 14. Arabinogalactan-Proteins in Pollen Tube Growth; E.M. Lord, et al. Section 5: Arabinogalactan-Proteins in Vegetative Development. 15. Arabinogalactan-Proteins, Place-Dependent Suppression and Plant Morphogenesis; D.V. Basile, et al. 16. Xylem-Specific Expression of Arabinogalactan-Protein-Like Genes; C.A. Loopstra, et al. 17. Induction of Phyletic Phenocopies in Streptocarpus (Gesneriaceae) by Three Antagonists of Hydroxyproline-Protein Synthesis; R.A. Rauh, D.V. Basile. 18. Evidence for the Interrelated Actions of Auxin, Ethylene, and Arabinogalactan-Proteins on the Transition from Non-Apical to Apical Growth of Physcomitrella patens Hedw. (Funariaceae); M.M. Mignone, D.V. Basile. Section 6: Medically and Industrially Important Arabinogalactan-Proteins and Related Macromolecules. 19. Bioactive Arabinogalactan-Proteins and Related Pectic Polysaccharides in Sino-Japanese Herbal Medicines; H. Yamada. 20. Uses of Gum Arabic (Acacia sp.) in the Food and Pharmaceutial Industries; F.M. Ward. 21. Structural Analysis of Gum from Acacia senegal (Gum Arabic); P.A. Williams, et al. 22. Promising Gums from Sourc

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less