Biochemistry Books

Book SynopsisTable of Contents1. The Structure and Function of Secondary Metabolites that are Secreted by Bacteria2. The Reagents, Supplies and Equipment that are Necessary to Grow Cultures of Bacteria in the Laboratory and to Purify Secreted Metabolites3. Overview of the Methods for Purification of Metabolites that are Secreted by Bacteria4. Absorption Spectrophotometry: Ultraviolet-visible and Infrared5. High-performance Liquid Chromatography6. Mass Spectrometry7. X-ray Crystallography8. Nuclear Magnetic Resonance Spectroscopy9. Exercises in Purifying and Characterizing a Quorum-sensing Signal10. Exercises in Purifying and Characterizing Iron-chelating Molecules11. Exercises in Purifying and Characterizing a Chloroplast-targeting Phytotoxin12. Designing your Own Experiments

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Book SynopsisBiochemistry: The Molecular Basis of Life is an intermediate, one-semester text written for students on degree pathways in Chemistry, Biology, and other Health and Life Sciences. Designed for students who need a solid introduction to biochemistry, but are not specializing in the subject, the text focuses on essential biochemical principles that underpin the modern life sciences, and offers the most balanced coverage of chemistry and biology of any text on the market. The text equips students with a complete view of the living state, emphasizes problem solving, and applies biochemical principles to the fields of Health, Agriculture, Engineering, and Forensics, to show students the relevance of their learning. McKee and McKee is respected for its balance of biology and chemistry, consistently placing biochemical principles into the context of the physiology of the cell and biomedical applications.Trade ReviewMcKee's Biochemistry is by far the best available textbook on the market for a one semester undergraduate Biochemistry course. It is very reader-friendly and has a better flow than most Biochemistry textbooks. This textbook goes beyond being a good reference book for students. Several features like key concepts, medical correlations, chapter summaries, 'Biochemistry in Perspective,' and end-of-chapter problems help guide learning and provide valuable study materials. * Niina Ronkainen, Benedictine University *McKee's Biochemistry is an excellent, one-semester biochemistry text that covers the major topics to an appropriate depth for health professions students. It is concise yet provides enough details to lay a solid biochemistry foundation. * Joe Deweese, Lipscomb University *The amount of material covered and the depth of the coverage is very good for a one-semester biochemistry course. The clinical examples to start each chapter are very nice and a good way to interest students in the material. The writing is at a level that will be helpful to students. * Michael Gunther, West Virginia University *Table of ContentsChapter Opening Vignettes Biochemistry in Perspective Essays Biochemistry in the Lab Boxes Preface General and Organic Chemistry Review Primer 1. Biochemistry: An Introduction 2. Living Cells 3. Water: The Matrix of Life 4. Energy 5. Amino Acids, Peptides, and Proteins 6. Enzymes 7. Carbohydrates 8. Carbohydrate Metabolism 9. Aerobic Metabolism I: The Citric Acid Cycle 10. Aerobic Metabolism II: Electron Transport and Oxidative Phosphorylation 11. Lipids and Membranes 12. Lipid Metabolism 13. Photosynthesis 14. Nitrogen Metabolism I: Synthesis 15. Nitrogen Metabolism II: Degradation 16. Integration of Metabolism 17. Nucleic Acids 18. Genetic Information 19. Protein Synthesis Appendix: Solutions Credits

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Book SynopsisYou are what you eat, and today's consumers care about the origins of their food. Artisanal food embodies those concerns, tailoring processes to raw materials to achieve the artisan's vision of the perfect product. The Science and Craft of Artisanal Food describes the science behind small and large-scale production of food, distinguishing artisanal production from normal commercial practice.Table of Contents1. Marketing Artisanal Products 2. Beer: Artfully Scientific on Every Level 3. Artist Winemaker 4. Artisanal Chocolate 5. Artisanal Coffee 6. Artisanal Cheese 7. The Chemistry and Flavor of Artisanal Honey 8. Industrial and Artisanal Olive Oil 9. Artisanal Fruits and Vegetables

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Book SynopsisThis work addresses the question of why minerals form in a large variety of organisms, from bacteria to man. The authors discuss the basic principles of mineral formation by organisms, and compare the various mineralization processes.Trade Review`The authors are to be congratulated on the hard work which has gone into a text which is highly informative, and does not get bogged down in details or dead-ends.' Mineralogical Society'... excellent book ... There is a wealth of new and newly synthesized information, including dozens of previously unpublished scanning electron micrographs ... This lucid and remarkably wide-ranging volume will provide a fine basis for the work to come.' Journal of Geology'The book provides an excellent introduction to the many aspects of the field, with extensive references to the literature. The text is generally very readable, with a smooth flow of words, and not excessively formal. Throughout the work the enthusiasm of the authors and their fascination with the topic shine through. Line drawings and photographs are well reproduced. The book is well bound and should survive frequent use.' C. Sancetta, Marine Geology, 110 (1993)Table of ContentsMinerals and macromolecules; Biomineralization processes; Protoctista; Cnidaria; Mollusca; Arthropoda; Echinodermata; Chordata; Some non-skeletal functions in biomineralization; Environmental influences on biomineralization; Evolution of biomineralization.

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Book SynopsisThis book is one of the first to apply engineering science and technology to biological cells and tissues that are electrically conducting and excitable. It describes the theory and a wide range of applications in both electric and magnetic fields. The similarities and differences between bioelectricity and biomagnetism are described in detail from the viewpoint of lead field theory. This book will enable readers to understand the properties of existing bioelectric and biomagnetic measurements and stimulation methods, and to design new systems. It includes carefully drawn illustrations and 500 references, and can be used as a textbook and as a reference.Trade Review"The book...is comprehensive and well-organized, and nicely edited and produced."--Engineering in Medicine and BiologyTable of ContentsPART I: ANATOMICAL AND PHYSIOLOGICAL BASIS OF BIOELECTROMAGNETISM; PART II: BIOELECTRIC SOURCES AND CONDUCTORS AND THEIR MODELLING; PART III: THEORETICAL METHODS IN BIOELECTROMAGNETISM; PART IV: ELECTRIC AND MAGNETIC MEASUREMENT OF THE ELECTRIC ACTIVITY OF NEURAL TISSUE; PART V: ELECTRIC AND MAGNETIC MEASUREMENT OF THE ELECTRIC ACTIVITY OF THE HEART; PART VI: ELECTRIC AND MAGNETIC STIMULATION OF NEURAL TISSUE; PART VII: ELECTRIC AND MAGNETIC STIMULATION OF THE HEART; PART VIII: MEASUREMENT OF THE INTRINSIC ELECTRIC PROPERTIES OF BIOLOGICAL TISSUES; PART IX: OTHER BIOELECTROMAGNETIC PHENOMENA

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Book SynopsisThis second and final volume of the biography of Hans Krebs covers his early years in England, 1933-1937, when he laid the foundations of our modern understanding of intermediary metabolism.Trade Review'This is not only a study of Krebs's research, it is also a comprehensive biography of Krebs's personal as well as scientific life ... These two volumes represent an extraordinary achievement, as a biography of a man, living in a time of turmoil and upheaval, who emerged as a great scientists. The story of both the man and the science is full and rewarding. Among studies of biochemists, I know of nothing in the least comparable with Holmes's achievement here, in its depth and breadth.' John T. Edsall, Harvard University, Nature, Vol. 366, December 1993'This is the second and concluding volume of Holmes' biography of Hans Krebs ... a remarkable ad detailed account of a significant period in the development of biochemistry, reflected in the work of a major "architect."' Nathaniel I. Berlin, University of Miami, JAMA, Vol. 271, No. 14, 1994'Tis is a substantial scientific biography covering four years of the life of Krebs ... There is an enormous amount of detail and the book will be of interest mainly to scientific historians.' Aslib Book Guide, Vol. 59, No. 6, June 1994Table of ContentsIntroduction ; 1. A new home for a career ; 2. Laboratory life in Cambridge ; 3. Progress under pressure ; 4. New moves ; 5. Arrivals and partings ; 6. The "Great Work" ; 7. Relocations and dismutations ; 8. Main routes and carriers ; 9. Full circle ; 10. Reflections ; Guide to structural formulas ; Notes

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Book SynopsisIn what will certainly be one of the key works in the emerging science of complexity, Kauffman here presents a brilliant new paradigm for evolutionary biology. It extends the basic concepts of Darwinian evolution to accommodate recent findings and perspectives from the fields of biology, physics, chemistry, and mathematics. The book drives to the heart of the exciting debate on the origins of life and maintenance of order in complex biological systems. It focuses on the concept of self-organization - the first time this concept has been incorporated into evolutionary theory. The book shows how complex systems, contrary to expectations, can spontaneously exhibit stunning degrees of order, and how this order in turn is essential for the emergence and development of life on Earth. Origins of Order will advance our understanding of evolution and provoke considerable discussion among evolutionary, molecular, and developmental biologists.Trade Review. . . an integrative book that will become a landmark and a classic as we grope towards a more comprehensive and satisfying theory of evolution. * Stephen Jay Gould *Stuart Kauffman's book . . . is a global representation of a new field, that will greatly enhance our physical understanding of Nature . . . A superb reading, not limited to physicists and biologists, having most important implications in natural philosophy. * Manfred Eigen *Here is a big book with a big purpose. . . . The Origins of Order is the first book to be written by any of the complexity theorists themselves, and it presents Kauffman's view of the biological realm. . . . The Origins of Order will be seen as a major work in the progression of biological theory. At the very least, Kauffman has made a persuasive case to have his bold hypothesis heard. * Roger Lewin *Table of ContentsPART I: ADAPTATION ON THE EDGE OF CHAOS; PART II: THE CRYSTALLIZATION OF LIFE; PART III: ORDER AND ONTOGENY

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Book SynopsisThis is a simple, but complete, description of synchrotron sources and free electron lasers and of the corresponding instrumentation and techniques. The emphasis is on basic concepts and the mathematical formalism is reduced to a minimum.Trade Review... a useful and refreshing treatment of synchrotron radiation * A.M. Glazer, University of Oxford *... a unique source of information * A. Snigirev, ESRF, Grenoble *... will appeal to all synchrotron radiation users. * D.M. Lawson, Biological Chemistry Dept, John Innes Centre, Norwich *Table of Contents1. Smart tourist guide to a synchrotron light facility ; 2. The Facility ; 3. Applications of synchrotron light ; 4. Free electron lasers (FELs) ; 5. Future directions

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Book SynopsisThe technique of nuclear magnetic resonance (NMR) spectroscopy is an important tool in biochemistry and biophysics for the understanding of the structure and ultimately, the function of biomolecules. This textbook explains the salient features of biological NMR spectroscopy to undergraduates and postgraduates taking courses in NMR, biological NMR, physical biochemistry, and biophysics. Unlike other books in the general field of NMR (except the advanced treatises), the approach here is to introduce and make use of quantum mechanical product operators as well as the classical vector method of explaining the bewildering array of pulse sequences available today. The book covers two- dimensional, three- dimensional, and four- dimensional NMR and their application to protein and DNA structure determination. A unique feature is the coverage of the biological aspects of solid- state NMR spectroscopy. The author provides many selected examples from the research literature, illustrating the applTrade Review... written in a vibrant, enthusiastic style ... It will appeal to a wide readership, from undergraduate chemists ... biochemists and some biologists, to postdoctoral scientists working in this specialized field ... it is good value. * Chemistry in Britain, February 1996 *a very useful book ... I plan on using this book in my course for the foreseeable future and I highly recommend Biomolecular NMR Spectroscopy to you. * Kevin H. Mayo, University of Minnesota Health Sciences Center, Biophysical Journal, Volume 70, June 1996 *The author writes clearly and enthusiastically ... the strength of the book is its broad coverage of scores of applications of NMR to important biological problems ... Another positive aspect of Biomolecular NMR Spectroscopy is the care with which the author places NMR in the context of the larger scientific picture. * Patricia J. Lodi, nature structular biology volume 3 number 5 may 1996 *Table of ContentsPART 1: THEORY ; Introduction ; 1. Methods for spectral assignment - multidimensional NMR ; 2. Obtaining NMR structures ; PART II: PROTEINS ; 3. Protein structure ; 4. Protein folding ; PART III: ENZYMES ; 5. Enzyme function ; 6. Acyl and phosphoryl transfer enzymes ; 7. Other enzymes ; PART IV: NUCLEIC ACIDS AND CARBOHYDRATES ; 8. Nucleic acids and carbohydrates ; PART V: MEMBRANES ; 9. Structure of membranes and membrane proteins ; Appendix 1 Examples of product operator calculations ; Appendix 2 Useful NMR data on amino acid residues ; Appendix 3 Useful NMR data on oligonucleotide residues ; Appendix 4 Useful NMR data on common solvents ; Index

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Book SynopsisThe book describes the importance and impact of a number of elements, other than carbon, in biological chemistry. There is a short background describing the interaction of inorganic molecules, especially metal ions, with biomolecules. The major part of the book contains a survey of biologically important elements and includes briefly the roles played in such varied species as humans, crocodiles, chickens, fish, beetles and plants and in diseases such as cysticfibrosis, methemoglobemia and thalassemia.Trade ReviewWilkins and his wife Pat have produced a readable introduction to the topic of inorganic chemistry in biology. It is bang up to date and is an excellent introduction to the area for students. * Robert W. Hay, Chemistry in Britain, November 1997 *This book illustrates the importance of an interdisciplinary approach to modern science ... The book will provide an excellent basis to a lively approach to the teaching of inorganic chemistry. It is packed with information, but concise, readable, well-illustrated and affordable - I shall recommend it to my undergraduate and graduate students. * Peter J. Sadler, Education in Chemistry, January 1998 *Table of Contents1. The important elements in biology ; 2. The composition of metallobiomolecules ; 3. The examination of the properties of metalloproteins ; 4. Structures and functions ; 5. The s-block ; 6. The d-block-redox chemistry ; 7. The d-block-non-redox chemistry ; 8. The p-block ; Further reading ; Answers to questions

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Book SynopsisWritten by a leading author in the field, Introduction to Protein Science provides a wide-ranging perspective on the study of protein structure and function in the context of bioinformatics and genomics. Opportunities for active learning are provided both in the text and online, enabling students to develop their problem solving skills.Trade ReviewThe third edition of Introduction to Protein Science continues to be a brilliant superior textbook for undergraduate and new postgraduate students in biology and chemistry. * Acta Crystallographica Section D, Volume D72, Part 12 (pp. 1227-1309, 1 December 2016) *It would be difficult to express the qualities of this book better than Doolittle (2005) in his review of the first edition: How can a book with only seven chapters cover so many topics so thoroughly and so well? For one thing, Lesk is a gifted writer with a knack for making complex material eminently understandable. For another, he has managed an adroit balancing of the carefully crafted main text with dozens of well-situated "boxes" and "case studies", each of which provides intriguing connections to the subject at hand. * Acta Crystallographica Section D, Volume D72, Part 12 (pp. 1227-1309, 1 December 2016) *This new edition is, above all, an excellent update of the previous one. * Acta Crystallographica Section D, Volume D72, Part 12 (pp. 1227-1309, 1 December 2016) *Table of Contents1. Introduction ; 2. Protein structure ; 3. Protein structure determination ; 4. Bioinformatics of protein sequence and structure ; 5. Proteins as catalysts: enzyme structure, kinetics, and mechanism ; 6. Proteins with partners ; 7. Evolution of protein structure and function ; 8. Protein folding and design ; 9. Proteomics and systems biology

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Book SynopsisLeaves are among the most abundant organs on earth and are a defining feature of most terrestrial ecosystems. However, a leaf is also a potential meal for a hungry animal and the question therefore arises, why does so much foliage survive in nature? What mechanisms protect leaves so that, on a global scale, only a relatively small proportion of living leaf material is consumed? Leaf survival is in large part due to two processes: firstly, leaf-eating organisms fall prey to predators (top-down pressure on the herbivore); secondly, leaves defend themselves (bottom-up pressure on the herbivore). Remarkably, these two types of event are often linked; they are controlled and coordinated by plants and the molecular mechanisms that underlie this are now beginning to emerge. This novel text focuses exclusively on the leaf, on the herbivorous organisms that attack leaves, and the mechanisms that plants use to defend these vital organs. It begins with an assessment of the scale of herbivory, befTrade ReviewAn essential resource for graduate students and faculty and valuable for upper-division undergraduates. * Choice *Leaf Defence provides an excellent review of the rapidly evolving literature in this field. * Ian T. Baldwin, Nature Review *In a very succinct yet comprehensive format, Farmer explores the remarkably diverse means by which leaves defend themselves against herbivores ... As a guide, Farmer is engaging, authoritative and didactic ... [His] text is an enjoyable read for anyone interested in plant defences with an evolutionary perspective, accessible to a general audience from students studying ecological courses to interested biologists and biochemists. * Maria Jose Endara and Natasha L. Wiggins, Edinburgh Journal of Botany *Leaf Defence ... definitively provides the perfect read for beginners in the field to get up to date and, more importantly, sparks interest that will motivate to follow through with some of the questions. However, it also provides a very helpful overall conceptual framework that integrates and balances the very diverse scientific approaches and views in the field, which will make the volume also valuable to experienced researchers as a guideline and reference. The structure of the book is ingenious in its simplicity and logic. * Andre Kessler, Quarterly Review of Biology *Table of Contents1. Introduction: The leaf and the pressures it faces ; 2. Leaf colour patterning and leaf form ; 3. Structural defences and specialised defence cells ; 4. Chemical defences ; 5. Inducible defences and the jasmonate pathway ; 6. Top-down pressures and indirect defences ; 7. Release and escape from herbivory ; 8. Escape in space : The cliff trees of Socotra

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Book SynopsisChemistry enables our eyes to detect the world around us; it determines whether something tastes sweet or sour; it helps genetic information pass accurately from one generation to the next. Ultimately, chemistry powers life itself. We don''t need to dig very deep to answer the question: why do biologists need chemistry? Building on the success of the first three editions, Chemistry for the Biosciences introduces students to all the chemistry they need to understand the biological world. Renowned for its clear and straightforward explanations, the book uses everyday examples and analogies throughout to help students get to grips with chemical concepts, and presents them in context of biological systems wherever possible so they can see how chemistry relates to their wider studies. With topics drawn from organic, physical, and inorganic chemistry, students will encounter a broad range of essential concepts. Chemistry for the Biosciences includes many learning features - both in print andTable of Contents1: Introduction: why biologists need chemistry 2: Atoms: the foundations of life 3: Compounds and chemical bonding: bringing atoms together 4: Molecular interactions: holding it all together 5: Moles, concentrations, and dilutions: making sense of chemical numbers 6: Hydrocarbons: the framework of life 7: Functional groups: adding function to the framework of life 8: Molecular shape and structure: life in three dimensions 9: Isomerism: generating chemical variety 10: Biological macromolecules: the infrastructure of life 11: Metals in biology: life beyond carbon 12: Chemical reactions, oxidation, and reduction: bringing molecules to life 13: Reaction mechanisms: the chemical changes that drive the chemistry of life 14: Energy: what makes reactions go? 15: Equilibria: how far do reactions go? 16: Kinetics: what affects the speed of a reaction? 17: Acids, bases, and buffer solutions: life in an aqueous environment 18: Chemical analysis: characterizing chemical compounds

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Book SynopsisA balanced presentation of the concepts of physical chemistry, and their applications to biology and biochemistry. Written to straddle the worlds of physical chemistry and the life sciences, it shows how the tools of physical chemistry can elucidate biological questions.Table of ContentsFocus 1: Biochemical Thermodynamics: The First Law Focus 2: Biochemical Thermodynamics: The Second Law Focus 3: Water and Aqueous solutions Focus 4: Chemical equilibrium Focus 5: Ion and Electron Transport Focus 6: The Rates of Reactions Focus 7: Biochemical kinetics Focus 8: Atoms Focus 9: Molecules Focus 10: Macromolecules and self-assembly Focus 11: Biochemical spectroscopy Focus 12: Scattering techniques Focus 13: Gravimetric methods

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Book SynopsisWritten primarily for students embarking on an undergraduate bioscience degree, this primer introduces students to the essential topics in protein science clearly and concisely by describing the basic chemical structure of proteins, the factors that stabilize protein structures, protein function, and protein evolution. It begins by placing proteins in their general context in life. They are synthesized as amino-acid sequences encoded in genomes, and fold spontaneously to three-dimensional structures. This is the point where life makes the tremendous leap from the one-dimensional world of genome and amino-acid sequences, to the three-dimensional world of protein structures - indeed, the world which we inhabit. Protein Science prepares readers for later more advanced study of the subject, but will also leave readers who do not go on to such advanced study with a satisfying grasp of the essentials of the subject.Protein Science is supported by online resources and is available for studenTable of Contents1: Introduction 2: Protein structure 3: Purification and structure determination of proteins 4: Survey of protein functions 5: Protein evolution

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Book SynopsisIn the past few decades, the field of ecology has made huge advancements thanks to stable isotopes. Ecologists need to understand the principles of stable isotopes to fully appreciate many studies in their discipline. Ecologists also need to be aware of isotopic approaches to enrich their toolbox for further advancing the discipline. A Primer on Stable Isotopes in Ecology is a concise and foundational resource for anyone interested in acquiring theoretical and practical knowledge for the application of stable isotopes in ecology.Readers will gain a more in-depth and complete knowledge of stable isotopes and explore isotopic methods used in ecological research, learning about stable isotope definitions, measurement, ecological processes, and applications in research. Chapters include in-depth descriptions of stable isotopes and their notation, isotope fractionation, isotope mixing, heavy isotope enrichment, and quantification methods by mass spectrometry and laser spectroscopy. The textTable of Contents1: Stable isotopes as a tool for ecologists 2: Stable isotopes, notations, and standards 3: Isotopic fractionation 4: Isotope mixing 5: Heavy isotope enrichments 6: Measuring stable isotopes

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Book SynopsisEssentials of Human Nutrition provides a complete and student-friendly introduction to the field for those embarking on courses in nutrition, or related subjects, for the first time. Written by an international team of experts, every chapter is carefully edited to give consistently clear and coherent explanations of all of the essential principles of nutrition. Key Features BL Chapters cover a broad range of disciplines to help students develop a complete understanding of the subject.BL Inter-chapter links help students see connections between different topics and build up a coherent picture of the subject as a whole.BL The text explains the impact of nutritional principles applied in practice, for example, in the context of sports and health care.New to this EditionThis sixth edition has been updated to incorporate new research and emerging topics such as biomarkers, assessment of nutritional status, and binge-eating disorders. Digital Formats and ResourcesEssentials of Human Nutrition is available for students and institutions to purchase in a variety of formats, and is supported by online resources.BL The e-book offers a mobile experience and convenient access: www.oxfordtextbooks.co.uk/ebooksBL Lecturer resources BL Image bankTrade ReviewReview from previous edition A great introduction to basic nutrition, diet, factors influencing dietary choice, dietary needs through the life course, and a taster of how diet and poor nutrition can be both a cause and a consequence of disease.An essential textbook for any introductory course in nutrition.A comprehensive, well written, and relevant textbook which provides an excellent overview of the current field of human nutrition.Table of ContentsPart 1: Introducing Human Nutrition 1: A. Stewart Truswell, Jim Mann, and Leanne Hodson: Introduction Part 2: Energy and Macronutrients 2: Jim Mann and Andrew Reynolds: Carbohydrates 3: C. Murray Skeaff, Jim Mann, and Leanne Hodson: Lipids 4: Colleen S. Deane, Daniel J. Wilkinson, and Philip J. Atherton: Protein 5: Andrew M. Prentice: Energy 6: A. Stewart Truswell: Alcohol Part 3: Organic and Inorganic Essential Nutrients 7: Lewis J. James and Gethin H. Evans: Water, Electrolytes, and Acid-base Balance 8: Helen Lambert, Ohood Hakim, and Susan A. Lanham-New: Major Minerals: Calcium and Magnesium 9: Patrick MacPhail: Iron 10: Samir Samman, Sheila Skeaff, Christine D. Thomson, and A. Stewart Truswell: Trace Elements 11: David I. Thurnham: Vitamin A and Carotenoids 12: A. Stewart Truswell: The B Vitamins 13: A. Stewart Truswell and Jim Mann: Vitamins C and E 14: A. Stewart Truswell: Vitamins D and K 15: Bernhard Watzl: Other Biologically Active Substances in Plant Foods: Phytochemicals 16: Anne-Marie Minihane: Nutrition, Genetics, and Personalized Nutrition Part 4: Nutrition-Related Disorders 17: Mike Lean: Overweight and Obesity 18: A. Stewart Truswell: Protein-Energy Malnutrition 19: Jim Mann and Rachael McLean: Cardiovascular Diseases 20: Kathryn E. Bradbury and Timothy J. Key: Nutrition and Cancer 21: Jim Mann: Diabetes Mellitus and the Metabolic Syndrome 22: Hannah Turner and Robert Peveler: The Eating Disorders: Anorexia Nervosa, Bulimia Nervosa, Binge-Eating Disorder, and OSFED Part 5: Foods 23: Andrew Reynolds, A. Stewart Truswell, Margaret Allman-Farinelli, Meika Foster, Anna Rangan, Leanne Hodson, and Kim Bell-Anderson: Food Groups 24: Martijn B. Katan: Functional Foods and Health Claims 25: Peter Williams and Paul Brent: Food Toxicity and Safety Part 6: Changing Food Habits 26: A. Stewart Truswell and Helen Leach: Food Habits 27: A. Stewart Truswell, Leanne Hodson, and Jim Mann: Nutritional Recommendations for the General Population 28: Susan A. Jebb: Public Health Approaches to Implement Dietary Recommendations 29: C. Murray Skeaff: Dietary Patterns 30: Wilma Waterlander and Boyd Swinburn: Food Systems: Challenges and Ways Forward 31: Tim Lang and Pamela Mason: Nutrition, the Environment, and Sustainable Diets Part 7: Life Stages 32: Annie S. Anderson: Pre-Pregnancy, Pregnancy, and Lactation 33: Anne-Louise Heath, Helen Crawley, and Rachael Taylor: Infant Feeding and Eating Well for Toddlers 34: Rachael Taylor and Anne-Louise Heath: Childhood and Adolescent Nutrition 35: Sian Robinson and Clare Corish: Nutrition and Ageing Part 8: Nutritional Assessment 36: Philippa Lyons-Wall: Food Analysis, Food Composition Tables, and Databases 37: Jim Mann and Silke Morrison: Dietary Assessment 38: A. Stewart Truswell: Assessment of Nutritional Status 39: Nita G. Forouhi and Albert Koulman: Biomarkers Part 9: Applications 40: Louise M. Burke: Sports Nutrition 41: Claire Smith and Winsome R. Parnell: Nutritional Consequences of Poverty and Food Insecurity in Developed Countries 42: Suzie Ferrie: Food in Hospitals 43: Ross C. Smith: Nutritional Support for Hospital Patients

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Book SynopsisThis is a pioneering cognitive psychological study of Ayahuasca, a plant-based Amazonian psychotropic brew. Benny Shanon presents a comprehensive charting of the various facets of the special state of mind induced by Ayahuasca, and analyzes them from a cognitive psychological perspective. He also presents some philosophical reflections. Empirically, the research presented in this book is based on the systematic recording of the author''s extensive experiences with the brew and on the interviewing of a large number of informants: indigenous people, shamans, members of different religious sects using Ayahuasca, and travellers. In addition to its being the most thorough study of the Ayahuasca experience to date, the book lays the theoretical foundations for the psychological study of non-ordinary states of consciousness in general.Trade Review... a great book ... it makes a substantial contribution to our understanding of consciousness ... The strength of the book lies in the rich descriptions and analyses of the ayahuasca experience ... deserves to be widely read by those who are seriously interested in understanding the nature of consciousness and reality. * Journal of Scientific Exploration *The experiences described in this book are quite literally mind-blowing and the cosmic vision it describes will be of great interest to TC readers. Highly recommended. * The Cauldron *It deserves to be read by anyone interested in religion, mysticism, and conciousness - and who is not? it should be required reading for psychologists, psychiatrists, and neuroscientists, because it shows how absurdly simplistic are the biochemical, darwinianm and genetic models now dominating mind-science. * John Horgan, Maps Vol XIII 2003 *Shanon's authorial persona is earnest, serious, straightforward, absolutely trustworthy. Antipodes is suffused with a sense of genuine adventure. * John Horgan, author of Rational Mysticism *Shanon's pioneering work * Thomas B Roberts, Northern Illinois University *Table of ContentsPROLOGUE ; GENERAL BACKGROUND; THEORETICAL FOUNDATIONS; METHODOLOGY AND GENERAL STRUCTURE ; ATMOSPHERE AND GENERAL EFFECTS; OPEN EYE VISUALIZATIONS; A STRUCTURAL TYPOLOGY OF AYAHUASCA VISUALIZATIONS; INTERACTION AND NARRATION; THE CONTENTS OF VISIONS; THE THEMES OF VISIONS; IDEAS, INSIGHTS, AND REFLECTIONS; NON-VISUAL PERCEPTIONS; CONSCIOUSNESS I; TRANSFORMATIONS; TIME; MEANING AND SEMANTICS; CONSCIOUSNESS II; LIGHT ; STAGES AND ORDER; CONTEXTUAL CONSIDERATIONS; COGNITIVE PARAMETERS; DYNAMICS; A GENERAL THEORETICAL PERSPECTIVE; CONCLUDING PHILOSOPHICAL REFLECTIONS ; EPILOGUE ; APPENDIX (QUANTITATIVE DATA) ; BIBLIOGRAPHY

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Book SynopsisIntroduction to Glycobiology reveals the true impact of the sugars on biological systems, explaining their function at the molecular, cellular, and organismal level and their clinical relevance.Trade ReviewReview from previous edition This book is an absolute must for all lecturers and students alike of glycobiology ... Wholeheartedly recommended. * Microbiology Today, November 2006 *It covers the breadth of glycobiology very well and provides sufficient depth to provide a platform for further research. * Dr Gavin M. Brown, Lancaster University *Others are not written as clearly or concisely as Taylor and Drickamer. * Prof Y.C. Lee, John Hopkins University *I prefer this book highly above the other text books available. * Prof Dr J.P. Kamerling, Utrecht University *Dr Taylor and Professor Drickamer should be congratulated on writing a textbook that presents the enormous subject of glycobiology with energy and enthusiasm and doing so in a manner that should be accessible to their target audience. * Biochemist e-volution, April 2006 *Table of ContentsPART 1: STRUCTURES AND BIOSYNTHESIS OF GLYCANS; PART 2: GLYCANS IN BIOLOGY

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Book SynopsisGives a perfectly balanced overview of the field, describing the key infectious agents our bodies encounter and how our immune system responds to them. It also explains how diseases are spread and what measures we can take to control this spread, from vaccination to increasing public awareness.Trade ReviewInfectious disease affects everyone. If you are hoping to understand the mechanism of infections and immunity at an introductory level, then you will find this an excellent reference book: my copy is well thumbed and already sports a forest of bookmarks. * Susan Omar, The Biologist *Table of ContentsTHE INFECTIOUS ORGANISMS; THE IMMUNE SYSTEM; THE HOST-PATHOGEN BALANCE

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Book SynopsisSignalling within and between cells is one of the most important aspects of modern biochemistry and cell biology. An understanding of signalling pathways is vital to a wide range of biologists, from those who are investigating the causes of cancer, to those who are concerned about the impact of environmental pollutants on the ecosystem. The way cells adapt to changing environments, and the way cell dysfunction causes disease, is underpinned by cell signalling events. Cell Signalling presents a carefully structured and highly accessible introduction to this intricate and rapidly growing field. Starting with an overview of cell signalling and highlighting its importance in many biological systems, the book goes on to explore the key components of extracellular and intracellular signalling mechanisms, before examining how these components come together to create signalling pathways. A focus on common components and concepts, rather than mechanistic detail, allows the reader to gain a thorough understanding of the principles that underpin cell signalling. Online Resource CentreThe Online Resource Centre to accompany Cell Signalling features:For students:- Links to useful websitesFor registered adopters of the text:- Journal Clubs: suggested research papers and discussion questions linked to topics featured in the book- Figures from the book in electronic format for use in lecturesTrade ReviewA good overview of the key underlying concepts and principles, allowing students to gain a solid grounding in the subject. I like the Case Study sections which link to research findings; these provide relevant context and help students to understand the key message in complex scientific articles. * Dr Andrew Chantry, University of East Anglia *It is really the best specialist text for undergraduates on this topic I have seen. * Dr Fergus Doherty, University of Nottingham *Review from previous edition: John Hancock's Cell Signalling is a straightforward introduction to a rapidly expanding field of biology. Its unintimidating writing style, simple and uncluttered figures, and competitive price make it a wonderful introductory text for undergraduates. * Dr Laura K. Palmer, Penn State University *Review from previous edition: Complexity and specificity are the hallmarks of cell signalling, yet Hancock in this third edition has gone a long way to simplify these complicated processes. His signalling examples are clever and well-conceived, his writing descriptive and his passion for his subject infectious ... this is marvellous value for money and is a worthy companion to an undergraduate/postgraduate reference library. * John P. Phelan, Waterford Institute of Technology, Ireland in The Biochemist *Table of ContentsPART 1: AN OVERVIEW OF SIGNALLING; PART 2: COMPONENTS THAT COMPRISE SIGNALLING PATHWAYS; PART 3: SELECTED EXAMPLES OF SIGNALLING PATHWAYS AND EVENTS; PART 4: FINAL THOUGHTS

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Book SynopsisHormones are vital to the workings of the body, and while many people are aware of what hormones do, few have an appreciation of the nature and importance of the endocrine system. In this Very Short Introduction, Martin Luck explains what hormones are, what they do, where they come from, and how they work.Trade Reviewan informative and readable overview to the subject * Guardian *Table of Contents1. Hormones, history, and the shoulders of giants ; 2. What and how ; 3. Nuns, catastrophes, and the mysteries of reproduction ; 4. Water, salt, and blood pressure ; 5. The hard stuff: calcium, cells, bones, and cancer ; 6. Appetite, fat, and obesity ; 7. The thyroid gland ; 8. Light and dark ; 9. Changing perspectives ; Further reading ; Index

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Book SynopsisBiomedical scientists are the foundation of modern healthcare, from cancer screening to diagnosing HIV, from blood transfusion for surgery to food poisoning and infection control. Without biomedical scientists, the diagnosis of disease, the evaluation of the effectiveness of treatment, and research into the causes and cures of disease would not be possible. The Fundamentals of Biomedical Science series has been written to reflect the challenges of practicing biomedical science today. It draws together essential basic science with insights into laboratory practice to show how an understanding of the biology of disease is coupled to the analytical approaches that lead to diagnosis. Assuming only a minimum of prior knowledge, the series reviews the full range of disciplines to which a Biomedical Scientist may be exposed - from microbiology to cytopathology to transfusion science.Clinical Biochemistry provides a clear and comprehensive introduction to the biochemical basis of disease proceTable of Contents1: David Cameron: Biochemical investigations and quality control 2: Tim James: Automation 3: Edmund Lamb: Kidney disease 4: Joanne Marsden: Hyperuricaemia and gout 5: Tim James: Fluid and electrolyte disorders 6: David Tierney: Acid-base disorders 7: Paul Collinson and Amy Lloyd: Clinical enzymology and biomarkers 8: Roy Sherwood: Liver function tests 9: Mike France: Abnormalities of lipid metabolism 10: Nessar Ahmed: Disorders of calcium, phosphate, and magnesium homeostasis 11: Garry McDowell: Abnormal pituitary function 12: Garry McDowell: Thyroid disease 13: Allen Yates and Ian Laing: Diabetes mellitus and hypoglycaemia 14: John Honour: Adrenal disease 15: Ian Laing and Julie Thornton: Reproductive endocrinology 16: Pat Twomey and William Simpson: Biochemical nutrition 17: Garry McDowell and Gordon Brydon: Gastrointestinal disorders and malabsorption 18: Gerald Maguire: Specific protein markers 19: Joanne Adaway and Gilbert Wieringa: Cancer biochemistry and tumour markers 20: Mary Anne Preece: Inherited metabolic disorders and newborn screening 21: Robin Whelpton, Nigel Brown, and Robert Flanagan: Therapeutic drug monitoring 22: Gwendolen Ayers: Chemical toxicology

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Book SynopsisCrucible of Science is the story of a unique laboratory at Washington University in St. Louis, and of Carl and Gerty Cori, the biochemists who established it. Carl and Gerty met and married at medical school in Prague in the 1920s. After graduation, they immigrated to the U.S. to escape deteriorating conditions in Europe. Carl soon received an offer from Washington University to become Pharmacology Chair, and the couple settled in St. Louis. Not only did both Coris go on to win the Nobel Prize, the laboratory they established at the University has since produced some of the most outstanding scientists the U.S. has ever seen. Six laboratory scientists also won Nobel Prizes; few, if any, laboratories can claim such an impressive record. The Coris themselves were instrumental in establishing the then new science of Biochemistry in the U.S. They applied chemical approaches to elucidating the transformations of compounds such as glucose in animal tissues and defined the enzyme BIOL15GENRthaTable of ContentsINTRODUCTION ; CHAPTER 1 - CARL AND GERTY CORI ; CHAPTER 2 - SIDNEY COLOWICK - THEIR FIRST GRADUATE STUDENT ; CHAPTER 3 - HERMAN KALCKAR - THE GREAT DANE ; CHAPTER 4 - SEVERO OCHOA - SPANISH GENIUS ; CHAPTER 5 - MOVE TO ENZYMOLOGY AND WORK OF ARDA GREEN ; CHAPTER 6 - LUIS LELOIR - ONE OF ARGENTINA'S GREATEST SCIENTISTS ; CHAPTER 7 - EARL SUTHERLAND - MASTER OF INTUITION ; CHAPTER 8 - CORI'S MOVE TO THE DEPARTMENT OF BIOLOGICAL CHEMISTRY - AWARD OF NOBEL PRIZES AND CAREER OF TOM CORI ; CHAPTER 9 - SIDNEY VELICK - MODEST ENZYMOLOGIST ; CHAPTER 10 - VICTOR NAJJAR - PEDIATRICIAN AND IMMUNOCHEMIST ; CHAPTER 11 - EDWIN KREBS - ACCIDENTAL BIOCHEMIST ; CHAPTER 12 - MILDRED COHN - AGAINST ALL ODDS ; CHAPTER 13 - CHRISTIAN de DUVE - BELGIAN WITH SAVOIR FAIRE ; CHAPTER 14 - ARTHUR KORNBERG - A GIANT OF BIOCHEMISTRY ; CHAPTER 15 - HORMONE EFFECTS ON MUSCLE CARBOHYDRATE METABOLISM ; CHAPTER 16 - CHARLES PARK - ARISTOCRATIC PHYSIOLOGIST ; CHAPTER 17 - JANE HARTING PARK - ENTHUSIAST FOR SCIENCE ; CHAPTER 18 - GERTY CORI'S WORK ON GLYCOGEN STRUCTURE AND GLYCOGEN STORAGE DISEASES ; CHAPTER 19 - JOSEPH LARNER - FOCUS ON GLYCOGEN SYNTHASE ; CHAPTER 20 - CONTRIBUTIONS OF BARBARA AND DAVID BROWN ; CHAPTER 21 - WILLIAM DAUGHADAY - ALL ABOUT GROWTH ; CHAPTER 22 - ROBERT CRANE - A DECADE WITH CARL CORI ; CHAPTER 23 - ALBERTO SOLS - SPANISH ENZYMOLOGIST ; CHAPTER 24 - LUIS GLASER - THE COMPLEXITY OF CARBOHYDRATES ; CHAPTER 25 - ERNST HELMREICH - JOVIAL BAVARIAN ; CHAPTER 26 - CARL FRIEDEN - ENZYME KINETICIST ; CHAPTER 27 - DAVID KIPNIS - DIABETOLOGIST ; CHAPTER 28 - WILLIAM DANFORTH - ACADEMIC LEADER ; CHAPTER 29 - THE INFLUENCE OF THE CORIS ON WASHINGTON UNIVERSITY AND CARL CORI'S RESEARCH AT BOSTON ; CHAPTER 30 - THE HERITAGE OF THE CORIS

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Book SynopsisWe''re all familiar with the idea that plant-derived chemicals can have an impact on the functioning of the human brain. Most of us reach for a cup of coffee or tea in the morning, many of us occasionally eat some chocolate, some smoke a cigarette or take an herbal supplement, and some people use illicit drugs. We know a great deal about the mechanisms by which the psychoactive components of these various products have their effects on human brain function, but the question of why they have these effects has been almost totally ignored. This book sets out to describe not only how, in terms of pharmacology or psychopharmacology, but more importantly why plant- and fungus-derived chemicals have their effects on the human brain. The answer to this last question resides, in part, with the terrestrial world''s two dominant life forms, the plants and the insects, and the many ecological roles the ''secondary metabolite'' plant chemicals are trying to play; for instance, defending the plant against insect herbivores whilst attracting insect pollinators. The answer also resides in the intersecting genetic heritage of mammals, plants, and insects and the surprising biological similarities between the three taxa. In particular it revolves around the close correspondence between the brains of insects and humans, and the intercellular signaling pathways shared by plants and humans. Plants and the Human Brain describes and discusses both how and why phytochemicals affect brain function with respect to the three main groups of secondary metabolites: the alkaloids, which provide us with caffeine, a host of poisons, a handful of hallucinogens, and most drugs of abuse (e.g. morphine, cocaine, DMT, LSD, and nicotine); the phenolics, including polyphenols, which constitute a significant and beneficial part of our natural diet; and the terpenes, a group of multifunctional compounds which provide us with the active components of cannabis and a multitude of herbal extracts such as ginseng, ginkgo and valerian.Trade ReviewThis is an impressive book. ... I recommend reading it -- the writing is clear, lucid, and engaging. If you don't believe me, just read the first two paragraphs -- you will be hooked! * Dale Walters, Scotland's Rural College, Edinburgh *This book is a scholarly masterpiece of David O. Kennedy. If you want to understand the pharmacological mode of action of the psychoactive natural products and their role in human history, Plants and the Human Brain, is fascinating read. * Michael Wink, Heidelberg University, Germany *For plant biology collections, this book is a jewel. Highly recommended. * Sam Blu, Choice *I enjoyed reading this book and learnt much from it. It deserves to be read widely as there must be few people who have the breadth of knowledge themselves which is found in it and for such it will enhance their application of this fascinating topic. * Peter Houghton, Journal of Ethnopharmacology *The book is extremely well referenced; therefore, not only is the text a treasure of amazing scientific discourses, but it is also an excellent factual resource that enables the reader to go beyond the book's scope. The exciting debate about the link between plants and humans continutes, and Kennedy has provided a fascinating new synthesis and exciting new insights based on a critical assesment of biochemical, pharmacological, and phytochemical evidence. * BioScience *[A] landmark contribution to psychopharmacology and human health ... Students, teachers, and researchers of herbal medicine, biochemistry and phytochemistry, nutrition, psychopharmacology, ecology, and entomology should all avail themselves of the opportunity and pleasure to read this beautifully written book. * HerbalGram: The Journal of the American Botanical Council *Table of ContentsChapter 1: From shamans to starbucks ; Chapter 2: Secondary metabolites and the life of plants ; Chapter 3: More alike than we are unalike - Why do plant chemicals affect the human brain? ; Chapter 4: Alkaloids and the lives of plants and humans ; Chapter 5: The Rewarding Or Addictive Drugs ; Chapter 6: The Hallucinogens ; Chapter 7: The Deliriants - The nightshade (Solanaceae) family ; Chapter 8: Phenolics and the Lives of Plants and Animals ; Chapter 9: Phenolics and the human brain ; Chapter 10: Terpenes and the Lives of Plants and Animals ; Chapter 11: The Lamiaceae sub-tribe Salviinae - the Salvia, Rosmarinus and Melissa genera ; Chapter 12: Cannabis and the cannabinoids ; Chapter 13: Some Miscellaneous Terpenes ; Chapter 14: In conclusion, comparing and contrasting the alkaloids, phenolics and terpenes

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Book SynopsisThe ABC of Acid-Base Chemistry provides physiologists, medical students, and physicians with an intelligible outline of the elements of physiological acid-base chemistry. This new edition of Horace W. Davenport's standard text takes into account different ways of looking at the problems of acid-base derived from new instrumentation. The exposition has been modified to allow the student to apply his understanding to other systems of description of the acid-base status. Although the pH system has been retained, there is increasing emphasis on the use of hydrogen ion concentration. Topics discussed include: partial pressure of gases, composition of alveolar gas, transport of oxygen and carbon dioxide in the blood, buffer action of hemoglobin and seperated plasma, oxygenated whole blood and reduced blood, concepts of base excess and base deficit, and chemical regulation of respiration. Any reader who clearly understands the subject matter of this book will have a firm grounding in the prin

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Book SynopsisBefore the hydrogen bomb indelibly associated radioactivity with death, many chemists, physicians, botanists, and geneticists believed that radium might hold the secret to life. This book recovers a forgotten history of the connections between radioactivity and the life sciences that existed long before the dawn of molecular biology.Trade Review"Radium and the Secret of Life probes the experimental and metaphorical connections between transmutation and mutation. As that coupling makes clear, it was a book waiting to be written. Campos provides a deeply researched, engagingly written, and provocatively argued history of this potent conjunction and how it disintegrated so fully as to be nearly forgotten." (Angela N. H. Creager, author of Life Atomic)

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Book SynopsisToday's science tells us that our bodies are filled with molecular machinery that orchestrates all sorts of life processes. When we think, microscopic channelsopen and close in our brain cell membranes; when we run, tiny motorsspin in our muscle cell membranes; and when we see, light operates molecular switchesin our eyes and nerves. A molecular-mechanical vision of life has become commonplace in both the halls of philosophy and the offices of drug companies, where researchers are developing proton pump inhibitors or medicines similar to Prozac. Membranes to Molecular Machines explores just how late twentieth-century science came to think of our cells and bodies this way. This story is told through the lens of membrane research, an unwritten history at the crossroads of molecular biology, biochemistry, physiology, and the neurosciences, that directly feeds into today's synthetic biology as well as nano- and biotechnology. Mathias Grote shows how these sciences not only have made us think differently about life, they have, by reworking what membranes and proteins represent in laboratories, allowed us to manipulate life as active matterin new ways. Covering the science of biological membranes in the United States and Europe from the mid-1960s to the 1990s, this book connects that history to contemporary work with optogenetics, a method for stimulating individual neurons using light, and will enlighten and provoke anyone interested in the intersection of chemical research and the life sciencesfrom practitioner to historian to philosopher. The research described in the book and its central actor, Dieter Oesterhelt, were honored with the 2021 Albert Lasker Basic Medical Research Awardfor his contribution to the development of optogenetics.

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Book SynopsisTrade ReviewThe dearth of promising new treatments for many a serious disease remains a major challenge not just for the pharmaceutical industry but for all of society. In this exhaustively researched book, Brent R. Stockwell surveys the history of drug development and offers insightful suggestions for innovative new approaches. This is critical reading for the many involved in and concerned about this urgent issue. -- Robert Bazell, chief science correspondent, NBC News, and author of Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer This is a terrific book! Stockwell's writing is clear and engaging as he presents a thoughtful analysis of drug development that can be understood and appreciated by a diverse readership. Stockwell beautifully combines scientific history and personal anecdotes with clear explanations of the principles and practices of chemical biology to make a fascinating story of the past, present, and future of drug discovery. His book is informative, accurate, and a good read all put together. -- Geoffrey Cooper, Boston University, author of The Cell: A Molecular Approach and Oncogenes This is a truly wonderful book. Stockwell's writing will open the door to a universe that many readers may know little about. Drugs are born, biotech companies are created, scientists' careers are made and unmade, egos are raised and dashed. This book is so readable, it is an absolute page-turner. Yet it is also authoritative and scientifically sophisticated, managing to distill a complex, changing field into a beautifully written, well-crafted story. -- Siddhartha Mukherjee, Columbia University, author of The Emperor of All Maladies: A Biography of Cancer By providing accessible explanations for the underlying biological and chemical principles that apply to the complex solutions he describes, Stockwell enables even the scientifically unsophisticated reader to gain a wider perspective on what future disease treatment might entail. Publishers Weekly This very readable, even exciting work takes us through the medical breakthroughs of the past century. Globe and Mail This book deserves a readership, and there is certainly a need for it. As a drug companyresearcher, I have often wished that more people understood what the field was likeand how simultaneously fascinating and frustrating it can be. -- Derek B. Lowe Cell In this well-researched look into the complexities of making medicines, a chemical biologist gives a history of drug making and details innovative methods of drug discovery. Science News Despite our current political paralysis, government leaders should listen to Stockwell and be certain to advance our capacity to generate the drugs that our society and the world need. Harvard Magazine The book is well organized and includes many interesting, clever analogies to explain what can be complicated scientific problems. Choice An engaging and rewarding read... -- Donald C. Lo Journal of Clinical Investigation The reader is not only left with a satisfying overview of the proud history and future challenges of finding new medicines but also encouragement that Stockwell and his contemporaries are creatively committed to academic drug discovery. -- David Kroll Nature Chemistry Stockwell writes well-his prose is accessible to the educated reader, irrespective of his or her background. All of the personalities, errors and successes in contemporary drug discovery are presented. Stockwell enlivens their stories with anecdotes... -- Garrett A. FitzGerald Nature Medicine It is impossible to read this relatively short book...without being captured by the author's optimism about the future of drug development. -- Robert C. Young, M.D. Oncology TimesTable of ContentsList of Illustrations Preface Acknowledgments Abbreviations Part I. The Vanishing Cures 1. The Drug Discovery Crisis 2. A New Science of Molecules 3. The Birth of the First Cancer Drugs 4. A New Company Creating Drug Combinations 5. The Undruggable RAS Protein 6. The Druggable Genome Part II. The Path to the Next Generation of Medicines 7. Peering Inside Proteins 8. The Nature of Interactions Between Proteins 9. From Protein-Protein Interactions to Personalized Medicines 10. A Revolution in Peptide Synthesis 11. A Vast Array of Drug Candidates 12. Moving Outside the Small Molecule Box 13. Accelerating the Arrival of Next-Generation Drugs Notes Glossary Index

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Book SynopsisPsychoneuroimmunology is the first textbook to examine the complex functional relationships between the nervous system, the neuroendocrine and the immune system. The international leaders in this field have been brought together to create this pioneering text; each contributing from their area of expertise. The result is a comprehensive yet accessible interdisciplinary introduction to psychoneuroimmunology which also takes you further than the foundations of those fascinating topics by covering the most recent research in HIV/AIDS, autoimmune diseases, and the reactivation of latent herpes viruses. Attention is also given to the effects of behavior such as physical exercise, sleep, acute and chronic stress, and conditioning of immune functions in animals and humans. The whole is brought together with a wealth of cited research studies, and over 200 illuTable of Contents1.Functional Anatomy of the Immune System; J. Westermann, M.S. Exton. 2.Foundations in Immunology; R. Jacobs, R.E. Schmidt. 3.Principles of Endocrinology; T. H. Schürmeyer, E. J. Wickings. 4.Concepts in Psychology; U.Tewes. 5 Psychological Methods; U.Tewes, M. Schedlowski. 6.Endocrinological Methods; T. H. Schürmeyer, E. J. Wickings. 7.Methods in Immunology; R. Jacobs. 8. Molecular Anatomical Basis of Interactions between Nervous and Immune Systems in Health and Disease; E. Weihe, et al. 9.Neuroendocrine System and Immune Functions; M. Schedlowski, R. J. Benschop. 10. Opioid Peptide Production by the Immune System; C. J. Heijnen, A. Kavelaars. 11.The Immune-Neuroendocrine Network; H. O. Besedovsky, A. del Rey. 12.Sickness Behavior: A Neuroimmune-Based Response to Infectious Disease; R. Dantzer. 13.Stress Effects on Immune Function in Rodents; M. K. Demetrikopoulos, et al. 14.Behavior/Immune Relationships in Nonhuman Primates; M. L. Laudenslager, J. M. Worlein. 15.Acute Psychological Stress; R. J. Benshop, M. Schedlowski. 16.Concepts and Models of Immunological Change during Prolonged Stress; C. L. Coe. 17.Does Psychological Depression Cause Immune Suppression in Humans? M. Irwin, E. Friedman. 18.Exercise and Immune Functions; B. Klarlund Pedersen. 19.Biobehavioral Influences on Respiratory Immunity; J. Kugler. 20.Effects of PsychosocialInterventions on the Immune System; M. E. Kemeny, G. Miller. 21.Sleep and Immune Functions; J. Born. 22.Functional Relationship between the Olfactory and Immune Systems; F. Eggert, R. Ferstl. 23.Behavioral Conditioning of Immunity; M. S. Exton, et al. 24.Psychoneuroimmunology in Oncology; D. H. Bovbjerg, et al. 25.Psychoneuroimmunology and HIV/AIDS; N. Schneiderman, et al. 26.Psychoneuroimmunology and Autoimmune Diseases; A. Kavelaars, et al. 27.The Effects of Stress on the Immune System: Implications for Reactivation of Latent Herpesviruses; K. L. Applegate, et al. References. Index

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Book Synopsis

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Book SynopsisTable of ContentsIntroduction 1-Introduction II Molecules and cells 2 Amino Acids and Proteins 3- Carbohydrates and Lipids 4- Cells, Membranes and Transport. III. Metabolism 5- Hemoglobin and oxygen transport. 6- Catalytic Proteins - Enzymes 7- Coenzymes Vitamins and Minerals 8- Bioenergetics and Oxidative Metabolism 9- Anaerobic metabolism of glucose carbohydrates in the red blood cell 10-The Tricarboxylic Acid Cycle 11-Oxidative Metabolism of Lipids in Liver and Muscle 12- Biosynthesis and Storage of Carbohydrates in Liver and Muscle: Glycogen metabolism and gluconeogenesis 13- Biosynthesis and Storage of Fatty Acids 14-"Metabolism of cholesterol and steroids". 15- Biosynthesis and Degradation of Amino Acids 16- Biosynthesis and Degradation of Nucleotides. 17- Complex Carbohydrates: Glycoproteins. 18- Complex Lipids 19-The Extracellular Matrix. IV Molecular basis of inheritance 20- Deoxyribonucleic Acid. 21- Ribonucleic Acid. 22- Protein Synthesis and Turnover. 23- Regulation of Gene Expression: Basic Mechanisms 24- Fundamentals of recombinant DNA technology, molecular hybridisation and cloning 25- Genomics, Proteomics and Metabolomics. V Signalling and growth 26- Membrane Receptors and Signal Transduction 27- Neurotransmitters. 28- Biochemical Endocrinology. 29- Cellular Homeostasis: Cell Growth and Cancer. 30- Aging VI. Fuels Nutrients and Minerals 31- Digestion and Absorption of Nutrients: The Gastrointestinal Tract. 32- Glucose Homeostasis and Fuel Metabolism: Diabetes Mellitus. 33- Nutrients and diets, malnutrition and obesity 34- Lipoprotein Metabolism and Atherogenesis. VII. Specialized Tissues and Their Function. 35- The Role of Liver in Metabolism. 36- Kidney: Water and Electrolytes Homeostasis 37- Lung and the Regulation of Hydrogen Ion Concentration (Acid-Base Balance) 38- Energy Metabolism and Contraction Exercise 39- Bone Metabolism and Calcium Homeostasis. 40- Neurochemistry VIII. Blood and immunity. Clinical biochemistry. 41- Blood and Plasma Proteins. 42- Haemostasis and Thrombosis. 43- Oxidative stress and inflammation. 44-The Immune Response: Innate and adaptive immunity. Appendix - selected clinical laboratory reference ranges. Index

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Book SynopsisTable of ContentsPreface to the sixth edition Preface to the seventh edition Acknowledgements Part 1: Introducing clinical biochemistry 1 The clinical biochemistry laboratory 2 The use of the laboratory 3 Interpretation of results: general 4 Interpretation of results: diagnosis 5 Interpretation of results: monitoring 6 Analytical aspects Part 2: Core biochemistry 7 Fluid and electrolytes: basic concepts 8 Water and sodium balance: physiological mechanisms 9 Hyponatraemia: pathophysiology 10 Hyponatraemia: assessment and management 11 Hypernatraemia 12 Hyperkalaemia 13 Hypokalaemia 14 Intravenous fluid therapy 15 Investigation of renal function (1) 16 Investigation of renal function (2) 17 Urinalysis 18 Proteinuria 19 Acute kidney injury 20 Chronic kidney disease 21 Acid-base: concepts and vocabulary 22 Metabolic acid-base disorders 23 Respiratory and mixed acid-base disorders 24 Acid-base disorders: diagnosis and management 25 Proteins and enzymes 26 Immunoglobulins 27 Myocardial infarction 28 Liver function tests 29 Jaundice 30 Liver disease 31 Glucose metabolism and diabetes mellitus 32 Diagnosis and monitoring of diabetes mellitus 33 Diabetic ketoacidosis 34 Hypoglycaemia 35 Calcium regulation and hypocalcaemia 36 Hypercalcaemia 37 Phosphate and magnesium 38 Metabolic bone disease 39 Osteoporosis and fragility fractures Part 3: Endocrinology 40 Endocrine control 41 Dynamic function tests 42 Pituitary function 43 Growth disorders and acromegaly 44 Thyroid pathophysiology 45 Hypothyroidism 46 Hyperthyroidism 47 Adrenocortical pathophysiology 48 Hypofunction of the adrenal cortex 49 Hyperfunction of the adrenal cortex 50 Gonadal function 51 Subfertility Part 4: Specialised investigations 52 Nutritional assessment 53 Nutritional support 54 Parenteral nutrition 55 The metabolic response to injury 56 Gastrointestinal disorders 57 Disorders of the pancreas 58 Iron 59 Zinc and copper 60 Therapeutic drug monitoring 61 Toxicology 62 Metal poisoning 63 Alcohol 64 Ascites 65 Pleural fluid 66 Cerebrospinal fluid 67 Identification of body fluids 68 Lipoprotein metabolism 69 Clinical disorders of lipid metabolism 70 Hypertension 71 Cancer and its consequences 72 Tumour markers 73 Multiple endocrine neoplasia 74 Hyperuricaemia 75 Myopathy 76 Fetal monitoring and prenatal diagnosis 77 Pregnancy 78 Antenatal screening 79 Screening the newborn for disease 80 Paediatric biochemistry 81 Inborn errors of metabolism 82 Methods involving antibodies: immunoassay 83 Methods to separate and identify molecules 84 Selected inherited disorders Case history comments Index

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