Description

Book Synopsis

Based on the author's academic and industrial experience and backed by a thorough review of the literature, this book provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis.

Table of Contents

Peptide Fragmentation/Deletion Premature FMOC Deprotection Elimination Side Reactions Peptide Global Deprotection/Scavenger-Induced Side Reactions Peptide Rearrangement Side Reactions Side Reactions Occurring at Amino Acid/Peptide Activation Step Intramolecular Cyclization Side Reactions Side Reactions in Amino Groups in Peptide Synthesis Side Reactions in Hydroxyl, Carboxyl, Ester Groups in Peptide Synthesis Oxidation and Reduction Side Reactions in Peptide Synthesis Racemization in Peptide Synthesis Solvent and Residual Impurities in the Reagents Induced Side Reactions Dipeptide Formation Side Reactions (Redundant Amino Acid Incorporation) Reattachment of Peptides to the Solid Supports Addition Side Reactions in Peptide Synthesis Side Reactions in Phosphor Peptides Side Reactions in CYS Protein Fragmentations

Side Reactions in Peptide Synthesis

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    A Hardback by Yi Yang

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      Book details

      Publisher Elsevier
      Published 8 September 2015
      ISBN-13 9780128010099
      978-0128010099
      ISBN-10 0128010096
      Also in:
      Biochemistry

      Description

      Book Synopsis

      Based on the author's academic and industrial experience and backed by a thorough review of the literature, this book provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis.

      Table of Contents

      Peptide Fragmentation/Deletion Premature FMOC Deprotection Elimination Side Reactions Peptide Global Deprotection/Scavenger-Induced Side Reactions Peptide Rearrangement Side Reactions Side Reactions Occurring at Amino Acid/Peptide Activation Step Intramolecular Cyclization Side Reactions Side Reactions in Amino Groups in Peptide Synthesis Side Reactions in Hydroxyl, Carboxyl, Ester Groups in Peptide Synthesis Oxidation and Reduction Side Reactions in Peptide Synthesis Racemization in Peptide Synthesis Solvent and Residual Impurities in the Reagents Induced Side Reactions Dipeptide Formation Side Reactions (Redundant Amino Acid Incorporation) Reattachment of Peptides to the Solid Supports Addition Side Reactions in Peptide Synthesis Side Reactions in Phosphor Peptides Side Reactions in CYS Protein Fragmentations

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