Industrial chemistry and chemical engineering Books

Book SynopsisFundamentals of Interfacial Engineering provides chemical, electronic, mechanical, and biomedical engineers with a coherent, integrated introduction to the fundamental concepts that relate to interfacial phenomena with applications to different processes and product situations.Table of ContentsDefining Interfacial Engineering. Interaction Forces in Interfacial Systems. General Properties of Systems Containing Fluid Interfaces. Colloids. Amphiphilic Systems--Liquid-Liquid Interfaces. Polymers. Polymer Composites. Liquid Coating Processes. General Properties of Crystalline Solid Surfaces. Thin Films--Solid-Solid Interfaces Processed from the Vapor Phase. Grain Boundary Surfaces and Interfaces in Crystalline Solids. Index.

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Book SynopsisThis book is a welcome response to the general concerns for the generation and conservation of energy in the future. It gives a comprehensive overview of both the fundamental and applied aspects of solid polymer electrolytes. Topics discussed include: * Polymer Electrolyte-based Devices * Homopolymer Hosts * The Interaction between Polymer and Salt * Conductivity in Polymer Electrolytes * Polymer Electrolyte Architecture * Transport Properties Effects of Dynamic Disorder * The Electrode-Electrolyte Interface Newcomers and experts alike will greatly benefit from the lucid and objective analysis this book provides.Table of Contents2.2 Poly(ethylene imine). 2.3 Thia-alkanes. References. Chapter 3. The Interaction Between Polymer and Salt. 3.1 Ion Solvation by the Polymer. 3.2. Hard-Soft Acid-Base Principle. 3.3. Artions. 3.4. Complex Formation. References. Chapter 4. Structure and Morphology. 4.1 Crystalline Phases in Polymers. 4.2 Preparation of Polymer Electrolyte Films. 4.3 Solvent Deposited and Melt Recrystallized Films. 4.4 Solvent Effects on Morphology. 4.5 Trace Impurities. 4.6 Intercrystalline Amorphous Phases. 4.7 Polymer Electrolyte Structural Determination by EXAFS. 4.8 Phase Diagrams. 4.8.1 Thiocyanates of Monovalent Cations. 4.8.2 Halide Systems. 4.8.3 Tetraphenyl Borate Systems. 4.8.4 Halogen-Containing Complex Anionic Systems. 4.8.5 Perchlorate Systems. 4.8.6 Trifluoromethanesulfonate Systems. 4.9 Mesogenic PEO-Salt Systems. References. Chapter 5. Aspects of Conductivity in Polymer Electrolytes. 5.1 Total Direct-Current Conductivity. 5.1.1 Crystallinity in Polymer Electrolytes. 5.1.2 Salt Concentration. 5.2 Pressure Dependence of the Conductivity. 5.3 Mixed Salt Systems. 5.4 Mixed Conductors. References. Chapter 6. Polymer Electrolyte Architecture. 6.1 Non-Ether-Based Polymer Electrolytes. 6.2 Amorphous Polyether-Based Polymer Architecture. 6.3 Enhanced Chain Flexibility. 6.4 Mechanical Stability. 6.4.1 Networks. 6.4.2 Comb-Branched Copolymers. 6.4.3 Block Copolymers. 6.4.4 Random Polyethers. 6.5 Blends. 6.6 Single-Ion Conductors. 6.7 Salts. References. Chapter 7. Further Developments in Polymer Electrolyte Materials. 7.1 Proton Conductors. 7.1.1 Polyethers. 7.1.2 Polyamides. 7.1.3 Poly(acrylic acid). 7.1.4 Polyamines. 7.1.5 Poly(vinyl alcohol). 7.2 Ormocers. 7.2.1 The Sol-Gel Process. 7.2.2 Ormolytes. 7.3 Multivalent Cation-Based Polymer Electrolytes. 7.3.1 Preparation of Materials. 7.3.2 Physical Properties. 7.3.2.1 Alkaline Earth Metal Cations. 7.3.2.2 Zinc(II). 7.3.2.3 Cadmium(II). 7.3.2.4 Lead(II). 7.3.2.5 Cobalt(II), Nickel(II), and Manganese(II). 7.3.2.6 Mercury(II). 7.3.2.7 Copper(II). 7.3.2.8 Trivalent Cation-Containing Electrolytes. References. Chapter 8. Transport Properties: Effects of Dynamic Disorder. 8.1 Macroscopic Models. 8.2 Microscopic Approach. 8.3 Experimental Techniques Relating to Microscopic Dynamic Properties. 8.3.1 Brillouin Scattering. 8.3.2 Dielectric Relaxation. 8.3.3 Nuclear Magnetic Resonance Spectroscopy. 8.3.4 Quasi-elastic Neutron Scattering. References. Chapter 9. Transport Properties: Ionic Species and Mobility. 9.1 Ion-Ion Interactions. 9.2 Spectroscopic Studies. 9.2.1 General Interpretation of Spectral Data. 9.3 Transference Numbers. 9.3.1 Transport Numbers from Diffusion Coefficient Determinations. 9.3.1.1 Radiotracer Studies. 9.3.1.2 Pulsed Field Gradient NMR. 9.3.1.3 Electrochemical Determination of Diffusion Coefficients. 9.3.2 Measurement of the Transport of Charged Species Only. 9.3.2.1 Hittorf/Tubandt Method. 9.3.2.2 Concentration Cell Techniques. 9.3.2.3 Cells in Force Fields. 9.3.3 Transport under a Chemical Potential and Electrical Gradient. 9.3.3.1 Alternating-Current Impedance. 9.3.3.2 Direct-Current Polarization Methods. Fully Dissociated Electrolytes. Systems Containing Mobile Ion Pairs. Systems Containing Triple Ions. References. Chapter 10. The Electrode-Electrolyte Interface. 10.1 The Lithium-Polymer Electrolyte Interface. 10.2 Electrochemical Stability. 10.3 Intercalation. 10.4 Electrochromism of Intercalation Compounds. References. Index.

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Book SynopsisThe various techniques used to analyze the microstructures of polymers are presented in this book. High resolution and solid state techniques are described, and applications to both synthetic and biological polymers are discussed in detail. Particular emphasis is placed on the determination of polymer microstructure by NMR spectroscopy. Here attention is drawn to the connection between the microstructures and NMR spectra of polymers, and it is demonstrated that the local polymer conformation provides this link. The numerous examples illustrating this connection are a special feature of the book.Table of ContentsPreface 1. The Microstructure of Polymer Chains 1.1 Introduction 1.2 Polymers Are Macromolecules 1.3 Polymer Microstructures from Polymerization of Monomers 1.3.1 Directional Isomerism 1.3.2 Stereochemical Isomerism 1.3.3 Geometrical Isomerism 1.3.4 Truly Asymmetric Polymers 1.3.5 Copolymer Sequences 1.4 Organization of Polymer Chains 1.5 Polymer Properties and Their Relation to Microstructure 2. Nuclear Magnetic Resonance 2.1 Introduction 2.2 The NMR Phenomenon 2.2.1 Resonance 2.2.2 Interactions and Relaxations of Nuclear Spins 2.2.3 Chemical Shift 2.2.4 Spin-Spin Coupling 2.3 Experimental Observation of NMR 3. High-Resolution NMR of Polymers 3.1 Introduction 3.2 ¯1H NMR 3.3 ¯13C NMR 3.4 High-Resolution ¯13C NMR in the Solid State 3.4.1 Dipolar Broadening 3.4.2 Chemical-Shift Anisotropy 3.4.3 Cross-Polarization 3.5 Two-Dimensional NMR 3.6 Other Nuclei-¯15N, ¯19F, ¯29Si, and ¯31p 4. ¯13C NMR of Polymers 4.1 Introduction 4.2 ¯13C Chemical Shifts and Their Dependence on Microstructure 4.2.1 ¯13C Nuclear Shielding 4.2.2 Substituent Effects on ¯13C Chemical Shifts 4.2.3 The -Substituent Effect in ¯13C NMR 4.2.4 -gauche Effects in ¯13C NMR 5. -gauche Effect Method of Predicting ¯13C NMR Chemical Shifts 5.1 Introduction 5.2 Polymer Conformations 5.2.1 Rotational Isomeric-State Model of Polymers 5.2.2 Average Bond Conformations 5.3 -gauche Effect Calculation of ¯13C NMR Chemical Shifts 5.3.1 Small-Molecule Example 5.3.2 Macromolecular Example 6. Determination of Stereosequences in Vinyl Polymers 6.1 Introduction 6.2 Traditional Methods 6.2.1 Stereoregular Polymers 6.2.2 Epimerization of Stereoregular Polymers 6.2.3 Model Compounds 6.2.4 Assumed Polymerization Mechanism 6.3 2D NMR Determination of Vinyl Polymer Stereosequence 6.4 Application of -gauche Effect Method 6.5 Establishing Vinyl Polymerization Mechanisms from Stereosequence Analysis 7. Microstructural Defects in Polymers 7.1 Introduction 7.2 Determining the Regiosequence of PVF_2 7.2.1 ¯13C NMR 7.2.2 ¯19F NMR 7.2.3 2D ¯19F NMR 7.3 Regiosequence Defects in PPO 8. Copolymer Microstructure 8.1 Introduction 8.2 Comonomer Sequences 8.3 Copolymer Stereosequences 8.4 Copolymer Conformations 8.5 Copolymerization Mechanisms 9. Chemically Modified Polymers 9.1 Introduction 9.2 Transformation of PVC to Ethylene-Vinyl Chloride Copolymers 9.2.1 Tri-n-butyltin Hydride Reduction of PVC 9.2.2 Microstructures of E-V Copolymers 9.2.3 (n-Bu)_3SnH Reduction of PVC Model Compounds 9.2.4 Computer Simulation of TCH and PVC Reduction 9.3 Modification of 1,4-Poly(butadienes) with Dihalocarbenes 9.3.1 Possible Microstructures in the Dihalocarbene Adducts of PBD 9.3.2 NMR of Dihalocarbene Adducts of PBD 10. Biopolymers 10.1 Introduction 10.2 Polypeptides 10.2.1 2D NMR Assignment of ¯1H Resonances 10.2.2 Determination of Polypeptide Conformation by 2D NMR 10.3 Polynucleotides 10.4 Polysaccharides 11. Solid Polymers 11.1 Introduction 11.2 Solid-State Polymer Conformation 11.3 Interchain Packing in Solid Polymers 11.4 Molecular Motion in Solid Polymers 11.5 Application of CPMAS/DD ¯13C NMR to Solid Polymers 11.5.1 Morphology and Motion in Polymer Crystals 11.5.2 Solid-Solid Polymer Phase Transitions 11.6 Other Nuclei Observed In Solid-State Polymer Spectra 11.6.1 CPMAS/DD ¯29Si NMR 11.6.2 MAS/DD ¯31p NMR 11.6.3 CPMAS/DD ¯15N NMR 11.7 Concluding Remarks

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Book SynopsisThis is a how to book that gives a brief but succinct and relevant information about US EPA's Toxic Substances Control Act (TSCA) to chemistry professionals working in corporate environment of a chemical industry followed by directions in complying with the TSCA inventory requirements.Trade Review"...presents step-by-step instructions for complying with regulations in the Environmental Protection Agency's Toxic Substances Control Act." (SciTech Book News, Vol. 26, No. 2, June 2002)Table of Contents1. Introduction. 2. Toxic Substances Control Act (TSCA). 2.1. Definition of Certain Terms under TSCA. 2.2. Provisions of the TSCA. 2.3. Who Is Subject to TSCA Compliance? 3. CAS Registry Numbers and TCSA Inventory Chemicals. 3.1. What Is a CAS Registry Number (CASRN)? 3.2. CASRN and TSCA Inventory Chemicals. 4. TSCA Inventory Requirements. 4.1. TSCA Inventory. 4.2. Bona Fide Intent to Manufacture (BIFM) Requests. 4.3. The Premanufacture Notice (PMN) Process. 4.4. Inventory Correction. 5. Processes for Assessing TSCA Inventory Requirements. 5.1. Process for Assessing TSCA Inventory Requirements of a Chemical for Chemical Processors. 5.2. Process for Assessing TSCA Inventory Requirements of a Chemical for Chemical Manufacturers. 5.3. Process for Assessing TSCA Inventory Requirements of a Chemical for Chemical Importers. 6. References. 7. Appendixes. 7.1. 15 USC OO2601–2629 as Amended through 1996. 7.2. 19 CFR 141.20. 7.3. 19 CFR 144.21 through 144.28. 7.4. 40 CFR OO721.90 and 721.91. 7.5. Notice of Commencement Form (EPA Form 7710–56). 7.6. Premanufacture Notice (PMN) Form (EPA Form 7710–25). 7.7. Compliance Verification Form (CVF). 7.8. PMN and NOC Instruction Manual. 7.9. Polymer Exemption Guidance Manual. 7.10. The PMN Review Process. 7.11. Chemical Information Needed for Risk Assessment. Index.

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Book SynopsisPlastic product design relies on the same formulas and procedures used for the design of metal, yet plastics are unique building materials that require more knowledge to produce acceptable results. This book states that plastic product designers must address specific quality control concerns to produce quality products at acceptable costs.Trade Review"...recommended to chemical engineers, materials scientists, technologists, and plastics manufacturers." (Polymer News) "...an excellent resource of practical information covering all the critical areas of thermoplastic part development." (IEEE Electrical Insulation Magazine, Vol. 19, No. 4, July-August 2003)Table of ContentsPreface. Introduction: Standard Plastic Terminology. Plastic Program Analysis and Development. Checklists for Product Design, Development, and Manufacture. Product Manufacturing Methods. Versatility of Design and Assembly with Plastics. Material Property Considerations. Property Considerations When Designing Products in Plastic. Temperature and Electrical Property Effects on Plastics. Design Analysis of Material Properties. Product Design Considerations. Structural Product Analysis. Design for Product Performance. Product and Tooling Design Guidelines. Plastic Product Design and Development Program Analysis. Appendix A: Checklist Forms. Appendix B: Glossary of Terms Used in Design and Development of Plastic Products. Index.

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Book SynopsisProvides a discussion of the regulatory requirements of FDA, ICH, Europe, and Japan as they pertain to calibration of instruments and validation of methods. This book offers practical tips on how to validate techniques. It explains why different approaches are necessary in biopharmaceutical and bioanalytical methods validation.Trade Review“It is a treasure of helpful hints and techniques which can aid even experienced analysts through some of the ICH procedures.” (Metrohm Information, 4th July 2005) "While most useful for pharmaceutical laboratories, it may also be useful in certain university and government laboratories." (E-STREAMS, February 2005) "…a treasure of helpful hints and techniques that can aid even experienced analysts through some of the ICH procedures." (Inside Laboratory Management, July/August 2004) "Given the need for generating reliable analytical data, this book provides practical guidance for validating common and not-so-common analytical methods and for verifying the performance of instruments…" (Journal of the American Chemical Society, June 9, 2004) “…a very useful reference text…warmly recommended” (Organic Process Research & Development Journal)Table of ContentsContributors. Preface. 1. Overview of Pharmaceutical Product Development and Its Associated Quality System (C. Chan & E. Jensen). 2. Potency Method Validation (C. Chan). 3. Method Validation for HPLC Analysis of Related Substances in Pharmaceutical Drug Products (Y. Lee). 4. Dissolution Method Validation (C. Chan, et al.). 5. Development and Validation of Automated Methods (C. Incledon & H. Lam). 6. Analysis of Pharmaceutical Inactive Ingredients (X. Zhang). 7. Validation Study of JP Heavy Metal Limit Test (Y. Nishiyama). 8. Bioanalytical Method Validation (F. Garofolo). 9. Procurement, Qualification, and Calibration of Laboratory Instruments: An Overview (H. Lam). 10. Performance Verification of UV-Vis Spectrophotometers (H. Lam). 11. Performance Verification of HPLC (H. Lam). 12. Operational Qualification of a Capillary Electrophoresis Instrument (N. Baryla). 13. LC-MS Instrument Calibration (F. Garofolo). 14. Karl Fisher Apparatus and Its Performance Verification (R. Jairam, et al.). 15. The pH Meter and Its Performance Verification (Y. Tse, et al.). 16. Qualification of Environmental Chambers (G. Wong & H. Lam). 17. Equipment Qualification and Computer System Validation (L. Huber). 18. Validation of Excel Spreadsheet (H. Brunner). Index.

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Book SynopsisThe indispensable resource for health professionals on potentially unsafe chemicals--now fully updated Proctor and Hughes'' Chemical Hazards of the Workplace, Fifth Edition provides a comprehensive reference text for health professionals who need toxicology data on chemicals that may be encountered in various work settings. Building on the success of the Fourth Edition-already a standard text-this new edition updates and revises the more than 600 entries of that text, and also adds monographs on new compounds. Introductory chapters cover toxicological concepts, clinical manifestations of exposure, the diagnosis of occupational disease, and industrial hygiene aspects of chemical exposures. The rest of the text consists of more than 625 alphabetically arranged entries on individual compounds, each of which includes: * Chemical formula * CAS number * 2003 ACGIH (American Conference of Government Industrial Hygienists) threshold limit value * SynonymsTrade Review“ … (this book) is a bit of a rare beast in that it is actually an easy-to-read reference book written in a narrative form.” (Health & Safety at Work, July 2005) "A good medical, university or special library serving safety professionals or students of these fields will want to have all of these reference works available for their patrons, and that includes the Proctor and Hughes." (E-STREAMS, January 2005) "...users of this reference may rely on this book to be the 'health' tile in a comprehensive chemical health and safety mosaic." (Facilities Manager, February 2005) "This book provides clinical information emphasizing human studies and cases rather than animal data whenever possible." (Industrial Hygiene News, January 2005) “…a substantial and well-organized text…” (Journal of Applied Toxicology, Vol24.No.6, November/ December 2004) “…(a) detailed book…explained in terms that are easily understood”. (Health & Safety Review, Vol.9, No.8, October 2004) "…an excellent and easy-to-use reference.” (Chemical Health & Safety, September-October 2004) "Health professionals should be pleased to have this updated volume available." (Vet Human Toxicology, 46 (4) August 2004)Table of ContentsI. Introduction: Toxicological Concepts. Toxicological Concepts—Setting Exposure Limits. II. The Chemical Hazards. Acetaldehyde. Acetamide. Acetic Acid. Acetic Anhydride. Acetone. Acetonitrile. 2-Acetylaminofluorene. Acetylene Tetrabromide. Acrolein. Acrylamide. Acrylic Acid. Acrylonitrile. Aldrin. Allyl Alcohol. Allyl Chloride. Allyl Glycidyl Ether. Allyl Propyl Disulfide. Aluminum. Aluminum Oxides. 4-Aminodiphenyl. p-Aminophenol. 2-Aminopyridine. Amitrole. Ammonia. Ammonium Chloride Fume. Ammonium Perfluorooctanoate. Ammonium Sulfamate. n-Amyl Acetate. sec-Amyl Acetate. Aniline. Anisidine. Antimony. Antu. Arsenic. Arsine. Asbestos. Asphalt Fumes. Atrazine. Azinphos-Methyl. Barium. Bauxite. Benomyl. Benz(A)Anthracene. Benzene. Benzidine. 2,3-Benzofuran. Benzoic Acid. Benzotrichloride. Benzoyl Peroxide. Benzo[A]Pyrene. Benzyl Chloride. Beryllium. Biphenyl. Bismuth Telluride. Bisphenol A. Borates. Boron Oxide. Boron Tribromide. Boron Trifluoride. Bromine. Bromine Pentafluoride. Bromodichloromethane. Bromoform. 1,3-Butadiene. n-Butane. n-Butyl Acetate. sec-Butyl Acetate. tert-Butyl Acetate. n-Butyl Acrylate. n-Butyl Alcohol. sec-Butyl Alcohol. tert-Butyl Alcohol. Butylamine. tert-Butyl Chromate. n-Butyl Glycidyl Ether. n-Butyl Mercaptan. Butylamine. o-sec-Butylphenol. p-tert-Butyl toluene. Cadmium. Calcium Carbonate. Calcium Cyanamide. Calcium Hydroxide. Calcium Oxide. Calcium Silicate. Calcium Sulfate. Camphor. Caprolactam. Carbaryl. Carbon Black. Carbon Dioxide. Carbon Disulfide. Carbon Monoxide. Carbon Tetrabromide. Carbon Tetrachloride. Catechol. Cellulose. Cesium Hydroxide. Chlordane. Chlordecone. Chlorinated Dibenzo-P-Dioxins . Chlorinated Diphenyl Oxide. Chlorine. Chlorine Dioxide. Chlorine Trifluoride. Chloroacetaldehyde. Chloroacetone. a-Chloroacetophenone. Chloroacetyl Chloride. Chlorobenzene. o-Chlorobenzylidene Malonitrile. Chlorobromomethane. p-Chloro-m-cresol. Chlorodibromomethane. Chlorodifluoromethane. Chlorodiphenyl, 42% chlorine. Chlorodiphenyl, 54% chlorine. Chloroform. bis(Chloromethyl)ether. Chloromethyl Methyl Ether. 1-Chloro-1-nitropropane. Chloropentafluoroethane. Chloropicrin. ß-Chloroprene. o-Chlorostyrene. Chlorothalonil. o-Chlorotoluene. Chlorpyrifos. Chromium. Chromyl Chloride. Chrysene. Coal Dust. Coal Tar Pitch Vol. Cobalt. Cobalt Hydrocarbonyl. Copper. Cotton Dust. Cresol. Crotonaldehyde. Cumene. Cyanamide. Cyanides. Cyanogen. Cyanogen Chloride. Cyclohexane. Cyclohexanol. Cyclohexanone. Cyclohexene. Cycloheximide. Cyclohexylamine. Cyclopentadiene. Cyclopentane. Cymene. Ddt. Decaborane. Decalin. Demeton. Di(Ethylhexyl) Phthalate. Diacetone Alcohol. Diaminotoluene. Diazomethane. Dibenz(A,H) Anthracene. Diborane. Dibromochloroproane. Dibutyl Cresol. Dibutyl Phenyl Phosphate. Dibutyl Phosphate. Dibutyl Phthalate. Dibutylaminoethanol. Dichloroacetylene. Dichlorobenzene-O. Dichlorobenzene-P. Dichlorobenzidine. Dichlorodifluormethane. Dichlorodimethylhydantoin. Dichloroethane. Dichloroethyl Ether. Dichloroethylene. Dichlorofluoromethane. Dichloronitroethane. Dichlorophenol. Dichlorophenoxyacetic Acid. Dichloropropene. Dichloropropionic Acid. Dichlorotetrafluoroethan. Dichlorvos. Dicyclopentadiene. Dicyclopentadienyl Iron. Dieldrin. Diepoxybutane. Diethanolamine. Diethyl Ketone. Diethyl Phthalate. Diethyl Sulfate. Diethylamine. Diethylaminoethanol. Diethylene Triamine. Diethylhexyl Adipate. Difluorodibromomethane . Diglycidyl Ether . Diisobutyl Ketone. Diisopropylamine. Dimethoxyethyl Phthalate. Dimethyl Acetamide. Dimethyl Carbamoyl Chloride. Dimethyl Hydrogen Phosphite. Dimethyl Methylphosphonate. Dimethyl Phthalate. Dimethyl Sulfate. Dimethylamine. Dimethylaminoazobenzene. Dimethylaniline. Dimethylformamide. Dimethylhydrazine. Dimethylphenol. Dinitro-O-Cresol. Dinitrobenzene. Dinitrophenol-2,4. Dinitrotoluene. Dioxane. Diphenylamine. Diphenylhydrazine. Dipropyl Ketone. Dipropylene Glycol Methyl. Diquat. Disulfiram. Disulfotone. Divinyl Benzene. Endosulfan. Endrin. Enflurane. Epichlorohydrin. Epn. Epoxy Resins. Epoxybutane. Ethane. Ethanolamine. Ethoxyethanol. Ethoxyethyl Acetate. Ethyl Acetate. Ethyl Acrylate. Ethyl Alcohol. Ethyl Amyl Ketone. Ethyl Benzene. Ethyl Bromide. Ethyl Butyl Ketone. Ethyl Chloride. Ethyl Ether. Ethyl Formate. Ethyl Mercaptan. Ethyl Silicate. Ethylamine. Ethylene. Ethylene Chlorohydrin. Ethylene Dibromide. Ethylene Dichloride. Ethylene Glycol. Ethylene Glycol Dinitrate. Ethylene Glycol Monobutyl Ether. Ethylene Oxide. Ethylene Thiourea. Ethylenediamine. Ethylenimine. Ethylhexyl Acrylate. Ethylidene Norbornene. Ethylmorpholine. Fenthion. Ferbam. Ferrovanadium Dust. Fibrous Glass. Fluoranthene. Fluorides. Fluorine. Formaldehyde. Formic Acid. Fuel Oils. Furfural. Furfuryl Alcohol. Gasoline. Germanium Tetrahydride. Glutaraldehyde. Glycidol. Graphite, Natural. Graphite, Synthetic. Hafnium. Halothane. Helium. Heptachlor. Heptachlor Epoxide. Heptane. Hexachlorobenzene. Hexachlorobutadiene. Hexachlorocyclopentadiene. Hexachloroethane. Hexachloronaphthalene. Hexafluoroacetone. Hexamethyl Phosphoramide. Hexamethylene Diisocyanate. Hexane. Hexyl Acetate. Hexylene Glycol. Hmx. Hydrazine. Hydrogen Bromide. Hydrogen Chloride. Hydrogen Cyanide. Hydrogen Fluoride. Hydrogen Peroxide. Hydrogen Selenide. Hydrogen Sulfide. Hydrogenated Terphenyls. Hydroquinone. Hydroxylamine. Hydroxypropyl Acrylate. Indene. Indenol Pyrene. Indium. Iodine. Iodoform. Iron Oxide Fume. Iron Pentacarbonyl. Isoamyl Acetate. Isoamyl Alcohol. Isobutane. Isobutyl Acetate. Isobutyl Alcohol. Isooctyl Alcohol. Isophorone. Isophorone Diisocyante. Isopropoxyethanol. Isopropyl Acetate. Isopropyl Alcohol. Isopropyl Ether. Isopropyl Glycidyl Ether. Isopropylamine. Isopropylaniline. Jet Fuel. Ketene. Lead. Lead Arsenate. Lead Chromate. Lindane. Liquified Petroleum. Lithium Hydride. Magnesite. Magnesium Oxide Fume. Malathion. Maleic Anhydride. Manganese. Manganese Cyclopentadienyl Tricarbonyl. Manganese Tetroxide. Mercury. Mercury (Alkyl). Mesityl Oxide. Methacrylic Acid. Methane. Methomyl. Methoxychlor. Methoxyethanol. Methoxyethyl Acetate. Methoxyphenol. Methyl Acetate. Methyl.Acetylene. Methyl Acrylate. Methyl Alcohol. Methyl Amyl Ketone. Methyl Aniline. Methyl Bromide. Methyl Butyl Ketone. Methyl Chloride. Methyl Cyanoacrylate. Methyl Ethyl Ketone. Methyl Ethyl Ketone Peroxide. Methyl Formate. Methyl Hydrazine. Methyl Iodide. Methyl Isbutyl Carbinol. Methyl Isoamyl Ketone. Methyl Isobutyl Ketone. Methyl Isocyanate. Methyl Isopropyl Ketone. Methyl Mercaptan. Methyl Methacrylate. Methyl Parathion. Methyl Propyl Ketone. Methyl Pyrrolidone. Methyl Silicate. Methyl Styrene. Methylacrylonitrile. Methylal. Methylamine. Methylcyclopentadienyl Manganese Tricarbonyl. Methylcyclohexane. Methylcyclohexanol. Methylcyclohexanone. Methylene Hexylisocyanate. Methylene Bis Chloroaniline. Methylene Bisphenyl Isocyanate. Methylene Chloride. Methylene Dianiline. Mevinphos. Mica. Molybdenum. Morpholine. Mustard Gas. Naled. Naphtha Coal Tar. Naphthalene. Naphthylamine. Natural Rubber Latex. Nickel . Nickel Carbonyl. Nicotine. Nitric Acid. Nitric Oxide. Nitroaniline. Nitrobenzene. Nitrochlorobenzene-O. Nitrochlorobenzene-P. Nitrodiphenyl. Nitroethane. Nitrogen Dioxide. Nitrogen Mustards. Nitrogen Trifluoride. Nitroglycerin. Nitromethane. Nitropropane-1. Nitropropane-2. Nitrosodi-N-Propylamine. Nitrosodimethylamine. Nitrosodiphenylamine. Nitrosomorpholine. Nitrotoluene. Nitrous Oxide. Nonane. Nonylphenol. Nuisance Particulates. Octachloronaphthalene. Octane. Oil Mist. Osmium Tetroxide. Oxalic Acid. Oxygen Difluoride. Ozone. Paraquat. Parathion. Particulate Matter. Pentaborane. Pentachloroethane. Pentachloronapthalene. Pentachlorophenol. Pentaerythritol. Pentane. Pentanedione. Perchloroethylene. Perchloromethyl.Mercaptan. Perchloryl.Fluoride. Phenol. Phenyl Ether. Phenyl Glycidyl Ether. Phenyl Mercaptan. Phenyl Naphthylamine. Phenylenediamine. Phenylethanol. Phenylhydrazine. Phenylphosphine. Phosgene. Phosphine. Phosphoric Acid. Phosphorus. Phosphorus Oxychloride. Phosphorus Pentachloride. Phosphorus Pentasulfide. Phosphorus Trichloride. Phthalic Anhydride. Phthalodinitrile-M. Picric Acid. Pindone. Piperazine Dihydrochloride. Platinum. Polybrominated Biphenyls. Polytetrafluoroethylene. Portland Cement. Potassium Hydroxide. Propane. Propane Sultone. Propargyl Alcohol. Propene. Propiolactone. Propionic Acid. Propyl Acetate. Propyl Alcohol. Propyl Nitrate. Propylene Dichloride. Propylene Glycol Dinitrate. Propylene Glycol Monomethyl. Propyleneimine. Propylene Oxide. Pyrethrum. Pyridine. Quinone. Radon. Rdx. Resorcinol. Rhodium. Ronnel. Rotenone. Selenium. Selenium Hexafluoride. Silica Amorphous-Diatomaceous. Silica Amorphous-Fume. Silica Crystal. Silicon. Silicon Carbide. Silicon Tetrahydride. Silver. Soapstone. Sodium Metabisulfite. Sodium Fluoroacetate. Sodium Hydroxide. Stibine. Stoddard Solvent. Strychnine. Styrene Monomer. Styrene Oxide. Sulfolane. Sulfur Dioxide. Sulfur Hexafluoride. Sulfur Monochloride. Sulfur Pentafluoride. Sulfur Tetrafluoride. Sulfuric Acid. Sulfuryl Fluoride. Talc (nonasbestos form). Tantalum. Tellurium. Tellurium Hexafluoride. Terphenyl. 1,1,2,2-Tetrachloro-1,2-difluoroethane. 1,1,2,2-Tetrachloroethane. Tetrachloronaphthalene. Tetraethyl Lead. Tetraethyl Pyrophosphate. Tetrahydrofuran. Tetralin. Tetramethyl Lead. Tetramethylsuccinonitrile. Tetranitromethane. Tetrasodium Pyrophosphate. Tetryl. Thallium. Thiazoles— Rubber Components. Thioacetamide. 4,4'-Thiobis(6-tert-butyl-m-cresol). Thioglycolic Acid. Thionyl Chloride. Thiram. Tin, Inorganic. Tin, Organic. Titanium Dioxide. Toluene. Toluene-2,4-Diisocyante. Toluidine. Toxaphene. Tributyl Phosphate. Trichloroacetic Acid. 1,2,4-Trichlorobenzene. 1,1,1-Trichloroethane. 1,1,2-Trichloroethane. Trichloroethylene. Trichlorofluoromethane. Trichloronaphthalene. 2,4,6-Trichlorophenol. 2,4,5-Trichlorophenoxyacetic Acid. 1,2,3-Trichloropropane. 1,1,2-Trichloro-1,2,2-trifluoroethane. Triethanolamine. Triethylamine. Triethylene Tetramine. Trifluoromonobromomethane. Trimellitic Anhydride. Trimethyl Phosphite. Trimethyl Benzene. Trimethylamine. 2,4,6-Trinitrotoluene. Triorthocresyl Phosphate. Triphenyl Amine. Triphenyl Phosphate. Triphenyl Phosphite. Tungsten. Turpentine. Uranium. Used Mineral-Based Crankcase Oil. n-Valeraldehyde. Vanadium Pentoxide. Vinyl Acetate. Vinyl Bromide. Vinyl Chloride. 4-Vinylcyclohexene Vinyl Cyclohexene Dioxide. Vinylcyclohexene. Vinylidene Chloride. Vinyltoluene. Vmp Naphtha. Warfarin. Wood Dust. Xylene. Xylidine (mixed isomers). Yttrium. Zinc Chloride. Zinc Dithiocarbamates—Rubber Components. Zinc Oxide. Zirconium Compounds. 3. Index Of Cas Numbers. 4. Index Of Compounds And Synonyms.

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Book SynopsisEcological Assessment of Polymers Strategies for Product Stewardship and Regulatory Programs John D. Hamilton and Roger Sutcliffe The expense of providing ecological assessments of new commercial products is formidable. The cost of the failure to comply with the current regulations--measured in fines, liability damages, and loss of public trust--is potentially much, much higher. Establishing effective environmental product stewardship strategies for assessment upfront not only promotes initial and continued compliance, it can reduce costs via the more efficient development of new products. Based on the collaboration of the Rohm and Haas Company and S.C. Johnson Wax with other manufacturers, contract laboratories, universities, and government agencies, Ecological Assessment of Polymers is the first complete reference to provide environment-oriented information about polymers from a product development and regulatory compliance perspective. A number of books deal with the potential hazarTable of ContentsINTRODUCTION AND OVERVIEW. Overview of Ecological Toxicity Test Methods. Overview of Ecological Fate Test Methods. Biodegradation Testing of Polymers in Soil. Biodegradation Testing of Polymers in Compost. ECOLOGICAL TOXICITY AND FATE ASSESSMENT. Polycarboxylates and Polyacrylate Superabsorbents. Water Treatment Polymers. Dispersion Polymers. Plastics. ENVIRONMENTAL REGULATIONS. Environmental Assessment of Polymers Under the U.S. Toxic Substances Control Act. Regulation of New Polymers in Canada. Regulation of New Polymers in the Pacific Region -- Part I. Regulation of New Polymers in the Pacific Region -- Part II. European Environmental Legislation for Polymers. NEW DIRECTIONS. Environmentally Biodegradable Polymers. Life-Cycle Assessment of Polymers. Index.

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Book SynopsisThis authoritative reference work provides a comprehensive overview of the current state of fullerene research. It covers topics of research interest such as solid state, metallofullerenes, nanotubes and organic functionalization.Trade Review"Chemists, physicists, pharmacologists, materials scientists, and chemical engineers survey the current understanding and application of the carbon-based materials." (SciTech Book News, Vol. 24, No. 4 December 2000)Table of ContentsElectrochemistry of Fullerenes (L. Echegoyen, et al.). Solubility of the Fullerenes (M. Korobov & A. Smith). Organic Chemistry of Fullerenes (S. Wilson, et al.). Structural Inorganic Chemistry of Fullerenes and Fullerene-Like Compounds (A. Balch). Photophysical Properties of Pristine Fullerenes, Functionalized Fullerenes, and Fullerene-Containing Donor-Bridge Acceptor Systems (D. Guldi & P. Kamat). Calculations of Higher Fullerenes and Quasi-Fullerenes (Z. Slanina, et al.). Polymer Derivatives of Fullerenes (L. Chiang & L. Wang). Endohedral Metallofullerenes: Production, Separation, and Structural Properties (H. Shinohara). Endohedral Metallofullerenes: Theory, Electrochemistry, and Chemical Reactions (S. Nagase, et al.). Biological Aspects of Fullerenes (S. Wilson). Carboxyfullerenes as Neuroprotective Antioxidants (L. Dugan, et al.). Fullerenes and Fullerene Ions in the Gas Phase (D. Bohme, et al.). Fullerene-Surface Interactions (A. Hamza). Structures of Fullerene-Based Solids ( K. Prassides & S. Margadonna). Fullerenes Under High Pressure (B. Sundqvist). Superconductivity in Fullerenes (V. Buntar). Boron Nitride-Containing Nanotubes (N. Chopra & A. Zettl). Synthesis and Characterization of Materials Incorporated within Carbon Nanotubes (J. Sloan & M. Green). Synthesis, Structure, and Properties of Carbon Encapsulated Metal Nanoparticles (M. McHenry & S. Subramoney). Molecular and Solid C_36 (J. Grossman, et al.). Index.

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Book SynopsisHow to hone your analytical skills and obtain high-quality data in the era of GMP requirements With increased regulatory pressures on the pharmaceutical industry, there is a growing need for capable analysts who can ensure appropriate scientific practices in laboratories and manufacturing sites worldwide.Trade Review"...chemists...explain how to comply with US Food and Drug Administration's Good Manufacturing Practice rules as analytical technologies are changing rapidly." (SciTech Book News, Vol. 24, No. 4, December 2000) "Anyone...involved in training exercises and in...gathering...pertinent material from different sources will find this book very helpful." (Journal of Medicinal Chemistry, Vol. 44, No. 21, 2001) "I recommend this book for anyone who recognizes a need for more and better training of pharmaceut9ical laboratory analysts...a remarkably rich resource." (Clinical Chemistry, Vol. 48, No. 3, 2002) "...provides a much needed perspective on the role of analytical chemistry in the pharmaceutical industry and is a welcome addition...a useful resource." (Journal of Chemical Education, December 2002)Table of ContentsThe Laboratory Analyst's Role in the Drug Development Process (J. Crowther, et al.). Laboratory Controls and Compliance (H. Avallone). The USP, ICH, and Other Compendial Methods (J. Feldman). Statistics in the Pharmaceutical Analysis Laboratory (A. Melveger). Basic Analytical Operations and Solution Chemistry (N. Snow & W. Murphy). Spectroscopy (P. Abauf & A. Melveger). Chromatographic Principles (J. Miller). Gas Chromatography (J. Miller & H. McNair). Liquid Chromatography: Basic Overview (L. Polite). HPLC Column Parameters (R. Hartwick). Dissolution (R. Kirchhoefer & R. Peeters). Analytical Method Development for Assay and Impurity Determination in Drug Substances and Drug Products (J. Crowther, et al.). Some Principles of Quantitative Analysis (J. Miller). Laboratory Data Systems (R. McDowall). Qualification of Laboratory Instrumentation, Validation, and Transfer of Analytical Methods (J. Crowther, et al.). Appendices. Index.

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Book SynopsisThis book brings together the most useful and important data on chemicals and gases used in the manufacture of semiconductor devices. It offers an A-to-Z listing of physical properties and safety information for more than 270 chemicals and gases used in the manufacture of semiconductor chips.Table of ContentsThin Film Deposition Materials. Wafer Cleaning Chemicals. Photolithography Materials. Wet and Dry Etching Materials. Chemical Mechanical Planarizing Materials. Carrier Gases. Uncategorized Materials. Semiconductor Chemicals Analysis. Index.

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Book SynopsisFrom the reviews of the First Edition: The book has admirably met its stated goal. The whole gamut of surface and colloid science has been presented in a comprehensive manner without any undue oversimplification. The author should be congratulated for his clarity. -Advanced Materials Now in its second edition, this work remains the single most useful introduction available to the complex area of surface and colloids science. Industry expert Drew Myers walks readers through concepts, theories, and applications-keeping the mathematics to a minimum and presenting real-world case studies to illustrate key technological and biological processes. He substantially reorganizes and updates the material to reflect the current state of knowledge in the field, offering new chapters on absorption and biological systems in addition to the important areas of colloid stability, emulsions and foams, monolayer films, surfactants, and wetting. This revision also boasts an improved index, more than 200 neTrade Review"Overall the book is very wordy, which may appeal to some readers, and in many cases the very qualitative approach may be useful to those coming to the subject from a very non-mathematical background." --Journal of Surfactants and Detergents Vol. 4, Issue 1 January 2001Table of ContentsSurfaces and Colloids: The Twilight Zone. Surfaces and Interfaces: General Concepts. Surface Activity and Surfactant Structures. Attractive Forces. Electrostatic Forces and the Electrical Double Layer. Capillarity. Solid Surfaces. Liquid-Fluid Interfaces. Adsorption. Colloids and Colloidal Stability. Emulsions. Foams. Aerosols. Polymers at Interfaces. Association Colloids: Micelles, Vesicles, and Membranes. Solubilization, Micellar Catalysis, and Microemulsions. Wetting and Spreading. Friction, Lubriation, and Wear. Adhesion. Bibliography. Index.

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Book SynopsisThe "HPLC Methods for Pharmaceutical Analysis" series allowed researchers to develop HPLC methods and analyze the most popular pharmaceutical compounds without the time and effort associated with intensive literature searches. This CD-ROM brings together volumes 1-4 of the series.

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Book SynopsisPeter Mirau presents an introduction to the theory and practice of NMR. He covers the fundamental principles of NMR and the applications to polymers. This book helps readers understand how these methods can be used to determine the chemical structure of polymers that influences the macroscopic properties.Trade Review"...useful for researchers or upper level undergraduate and graduate students exploring NMR for characterizing polymers." (E-STREAMS, April 2006) "...this book presents an introduction to the theory and practice of NMR..." (Apollit, 13th December 2005) "Students and researchers in polymer and analytical chemistry will find this book a useful resource." (Analytical Chemistry, February 1, 2005)Table of Contents1. Introduction to NMR. 1.1 Introduction. 1.2 Basic Principles of NMR. 1.2.1 Introduction. 1.2.2 Magnetic Resonance. 1.2.3 The Rotation Reference Frame. 1.2.4 The Bloch Equations. 1.2.5 Pulsed NMR. 1.2.6 The Fourier Transform. 1.2.7 The Product Operator Formalism. 1.3 Chemical Shifts and Polymer Structure. 1.3.1 Molecular Structure and Chemical Shifts. 1.3.2 Proton Chemical Shifts. 1.3.3 Carbon Chemical Shifts. 1.3.4 Other Nuclei. 1.4 Spin-Spin Coupling. 1.4.1 Introductions. 1.4.2 Nomenclature for Spin-Spin Coupling. 1.4.3 Spin-Spin Coupling Patterns. 1.4.4 Proton-Proton Coupling. 1.4.5 Proton-Carbon Coupling. 1.4.6 Other Nuclei. 1.4.7 Homonuclear Couplings in Insensitive Nuclei. 1.5 NMR Relaxation. 1.5.1 Introduction. 1.5.2 Relaxation Mechanisms. 1.5.3 Spin-Lattice Relaxation. 1.5.4 Spin-Spin Relaxation. 1.5.5 The Nuclear Overhauser Effect. 1.6 Solid State NMR. 1.6.1 Chemical Shift Anisotropy. 1.6.2 Magic-Angle Sample Spinning. 1.6.3 Dipolar Broadening and Decoupling. 1.6.4 Cross Polarization. 1.6.5 Quadrupolar NMR. 1.7 Multidimensional NMR. 1.7.1 Magnetization Transfer in nD NMR. 1.7.2 Solution 2D NMR Experiments. 1.7.3 Solid-State 2D NMR Experiments. 2. Experimental Methods. 2.1 Introduction. 2.2 The NMR Spectrometer. 2.2.1 The Magnet. 2.2.2 Shim Coils. 2.2.3 RF Console. 2.2.4 NMR Probes. 2.2.5 Computer. 2.3 Tuning the NMR Spectrometer. 2.3.1 Adjusting the Homogeneity. 2.3.2 Adjusting the Gain. 2.3.3 Tuning the Probe. 2.3.4 Adjusting the Pulse Widths. 2.4 Solution NMR Methods. 2.4.1 Sample Preparation. 2.4.2 Data Acquisition. 2.4.3 Decoupling. 2.4.4 Data Processing. 2.4.5 Quantitative NMR. 2.4.6 Sensitivity Enhancement. 2.4.7 Spectra Editing. 2.5 Solid-State NMR Methods. 2.5.1 Magic-Angle Sample Spinning. 2.5.2 Gross Polarization. 2.5.3 Decoupling. 2.5.4 Wideline NMR. 2.5.5 Solid-State Proton NMR. 2.6 NMR Relaxation. 2.6.1 NMR Relaxation in Solution. 2.6.2 Solid-State NMR Relaxation. 2.7 Multidimensional NMR. 2.7.1 Data Acquisition. 2.7.2 Data Processing. 3. The Solution Characterization of Polymers. 3.1 Introduction. 3.1.1 Polymer Microstructure. 3.1.2 Spectral Assignments in Polymers. 3.2 Stereochemical Characterization of Polymers. 3.2.1 The Observation of Stereochemical Isomerism. 3.2.2 Resonance Assignments for Stereosequences. 3.3 Regioisomerism in Polymers. 3.4 Defects in Polymers. 3.4.1 Branching. 3.4.2 Endgroups. 3.5 Polymer Chain Architecture. 3.6 Copolymer Characterization. 3.6.1 Random Copolymers. 3.6.2 Alternating Copolymers. 3.6.3 Block Copolymers. 3.7 The Solution Structure of Polymers. 3.7.1 Polymer Chain Conformation. 3.7.2 Intermolecular Interactions in Polymers. 4. The Solid-State NMR of Polymers. 4.1 Introduction. 4.2 Chain Conformation in Polymers. 4.2.1 Semicrystalline Polymers. 4.2.2 Amorphous Polymers. 4.2.3 Elastomers. 4.2.4 Reactivity and Curing in Polymers. 4.3 Structure and Morphology in Polymers. 4.3.1 Introduction. 4.3.2 Spin Diffusion and Polymer Morphology. 4.3.3 Semicrystalline Polymers. 4.3.4 Block Copolymers. 4.3.5 Multiphase Polymers. 4.3.6 Polymer Blends. 5. The Dynamics of Polymers. 5.1 Introduction. 5.2 Chain Motion of Polymers in Solution. 5.2.1 Modeling the Molecular Dynamics of Polymers in Solution. 5.2.2 Relaxation Measurements in Solution. 5.2.3 NMR Relaxation Measurements in Solution. 5.2.4 The Relaxation of Polymers in Solution. 5.3 NMR Relaxation in the Solid State. 5.3.1 Introduction. 5.3.2 NMR Relaxation in Solid Polymers. 5.3.3 Spin Exchange in Solid Polymers. 5.3.4 Polymer Dynamics and Lineshapes.

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Book SynopsisPolymer science is concerned with the structure, synthesis, physical properties, and utility of polymers. Polymers are macromolecular building blocks used to construct natural and man-made materials. Polymers from the Inside Out: An Introduction to Macromolecules provides an all-encompassing introduction to polymers and how they affect the world.Trade Review"The authors explain polymers' unique properties; contrast step-and chain-growth polymerization; and conclude with a focus on naturally-occurring biopolymers." (SciTech Book News, Vol. 25, No. 3, September 2001) "...introduces students to both synthesis and properties, but does so as a broad overview 'to facilitate either a one-semester or two-semester course in polymer science.'" (Choice, Vol. 39, No. 3, November 2001) "A really nice concise book for an introductory polymer course.... Well done!!!" (Polymer News, Vol. 26, No. 10, 2001) "...recommended reading for all those of us who have anything to do with plastics in any of its areas." ("...que es recomendable su lectura por parte de todos aquellos que nos relacionamos con los plasticos en cualquiere de sus ambitos.") (Centro Espanol de Plasticos, January/February 2002) "...an essential resource for the practising scientist..." (DKILit) "This book…will be of great use for professors of physics and chemistry." (Centro Espanol de Plasticos, August 2007)Table of ContentsPreface. Acknowledgments. Chapter Summary. Introduction. Step-Growth Polymerization. Chain-Growth Polymerization. The Microstructures of Polymers. The Conformational Characteristics of Polymers. Solution Properties of Polymers. Bulk Properties of Polymers. Naturally Occurring Biopolymers. Index.

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Book SynopsisThe book focuses on drug discovery for psychiatric and neurological diseases, which is in a phase of explosive growth. Chapters are divided into two major sections. The first section presents fundamentals of drug discovery, highlighting the modern techniques and approaches of drug discovery in biotech and pharmaceutical companies.Trade Review"It is a book I enjoyed reading; it is both expression and science." (Journal of Natural Products, October 2005) "…an outstanding overview of the current state of drug discovery…" (Drug Development and Industrial Pharmacy, No. 10, 2005) "…handy for old-timers who need a quick refresher on current therapy for neurological disorders." (Current Separations, August 2005) "…highly readable and informative. The entire book is carefully organized and very well written. It provides an excellent resource…" (American Journal of Pharmaceutical Education, Volume 69, Issue 4, 2005) "…recommended for all practitioners and advanced students who have an interest in this field." (E-STREAMS, August 2005) "...unique in providing an overview and synthesis of the current state of research on diseases of the nervous system, relevant pharmacological principles, and…the drug discovery process." (Doody's Book Review Service) "The text gives an overview of the state of current research, but also gives an outlook on possible future drug targets." (Drug Discovery & Development, February 2005) “...a marvelous text that offers the medical community a new perspective on both treatment and research.…” (Electric Review, November 2004)Table of ContentsPreface. 1. Introduction. 2. Drug Receptors and the Fundamentals of Pharmacology. 3. Drug Discovery. 4. Drug Target Selection for Nervous System Diseases. 5. From Drug Target to Drug, Neuroscience Specific Problems. 6. Schizophrenia. 7. Depression. 8. Anxiety Disorders. 9. Alzheimer’s Disease. 10. Parkinson’s Disease. 11. Ischemic Stroke, Brain and Spinal Cord Injury. 12. Other Neurodegenerative Diseases. 13. Sleep Disorders. 14. Epilepsy. 15. Pain. Index.

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Book SynopsisThe fifth edition of the Kirk-Othmer Encyclopedia of Chemical Technology builds upon the solid foundation of the previous editions, which have proven to be a mainstay for chemists, biochemists, and engineers at academic, industrial, and government institutions since publication of the first edition in 1949.Table of ContentsAlcohols, Higher Aliphatic, Survey 1 Alcohols, Higher Aliphatic, Synthetic Processes 26 Alcohols, Polyhydric 46 Aldehydes 58 Alkaloids 71 Alkanolamines from Nitro Alcohols 113 Alkanolamines from Olefin Oxides and Ammonia 122 Alkyd Resins 147 Alkylation 169 Alkylphenols 203 Allyl Alcohol and Monoallyl Derivatives 234 Allyl Monomers and Polymers 250 Aluminates 273 Aluminum and Aluminum Alloys 279 Aluminum Compounds, Survey 344 Aluminum Halides and Aluminum Nitrate 360 Aluminum Oxide (Alumina), Activated 391 Aluminum Oxide, Calcinated, Tabular, Cements 403 Aluminum Oxide (Alumina), Hydrated 421 Aluminum Sulfate and Alums 434 Amides, Fatty Acid 442 Amine Oxides 463 Amines by Reduction 476 Amines, Cycloaliphatic 498 Amines, Fatty 518 Amines, Lower Aliphatic Amines 537 Amino Acids 554 Amino Resins and Plastics 618 Aminophenols 652 Ammonia 678 Ammonium Compounds 711 Amyl Alcohols 762 Aniline and Its Derivatives 783 Antiaging Agents 810

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Book SynopsisThe fifth edition of the Kirk-Othmer Encyclopedia of Chemical Technology builds upon the solid foundation of the previous editions, which have proven to be a mainstay for chemists, biochemists, and engineers at academic, industrial, and government institutions since publication of the first edition in 1949.Table of ContentsAbrasives 1 Absorption 26 Acetaldehyde 99 Acetic Acid 115 Acetic Acid, Halogenated Derivatives 136 Acetic Anhydride 146 Acetone 160 Acetylene 177 Acetylene-Derived Chemicals 227 Acrolein and Derivatives 265 Acrylamide 288 Acrylamide Polymers 304 Acrylic Acid and its Derivatives 342 Acrylic Ester Polymers 369 Acrylonitrile 397 Acrylonitrile-Butadiene-Styrene (ABS) Polymers 414 Acrylonitrile Polymers, Survey and Styrene-Acrylonitrile (SAN) 439 Actinides and Transactinides 463 Adhesion 501 Adhesives 524 Adipic Acid 553 Adsorption 582 Adsorption, Gas Separation 617 Adsorption, Liquid Separation 664 Advanced Materials, Economic Evaluation 691 Aeration, Biotechnology 730 Aerogels 748 Aerosols 769 Air Pollution 787 Air Pollution and Control, Indoor 816

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Book SynopsisProvides a comprehensive introduction to the mechanical behaviour of solid polymers. Extensively revised and updated throughout, the second edition now includes new material on mechanical relaxations and anisotropy, composites modelling, non-linear viscoelasticity, yield behaviour and fracture of tough polymers. The accessible approach of the book has been retained with each chapter designed to be self contained and the theory and applications of the subject carefully introduced where appropriate. The latest developments in the field are included alongside worked examples, mathematical appendices and an extensive reference. * Fully revised and updated throughout to include all the latest developments in the field * Worked examples at the end of the chapter * An invaluable resource for students of materials science, chemistry, physics or engineering studying polymer scienceTable of ContentsPreface. 1 Structure of Polymers. 2 The Deformation of an Elastic Solid. 3 Rubber-like Elasticity. 4 Principles of Linear Viscoelasticity. 5 The Measurement of Viscoelastic Behaviour. 6 Experimental Studies of Linear Viscoelastic Behaviour as a Function of Frequency and Temperature: Time-Temperature Equivalence. 7 Anisotropic Mechanical Behaviour. 8 Polymer Composites: Macroscale and Microscale. 9 Relaxation Transitions: Experimental Behaviour and Molecular Interpretation. 10 Creep, Stress Relaxation and Non-linear Viscoelasticity. 11 Yielding and Instability in Polymers. 12 Breaking Phenomena. Appendix 1. Appendix 2. Answers to Problems. Index.

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Book SynopsisExplores the way in which peptides, proteins, nucleic acids and carbohydrates use therapeutically. With help of illustrations, this book covers both compounds and how therapeutics exert their influence through an understanding of biological processes.Trade Review"...an excellent introduction to biomacromolecular drugs..." (Chemistry in Britain, July 2002) "...a welcome addition to the library of any pharmacy student, chemistry instructor, or laboratory researcher." (The Annals of Pharmacotherapy, Vol. 36, October 2002 "...this is an excellent book..." (Organic Process Research and Development) "...many interesting snippets..." (Chemistry & Industry, 2 December 2002)Table of ContentsPreface. Abbreviations. Introduction. Endogenous Peptides and Proteins. Modification of Endogenous Peptides and Proteins. The Immune System. Oligonucleotides. Oligosaccharides. Appendix. Glossary. Index.

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Book SynopsisProviding a broad introduction to the growing field, this book explores the way in which peptides, proteins, nucleic acids and carbohydrates used therapeutically. With help of numerous illustrations, it covers both the compounds and how therapeutics exert their influence throuhg an understanding of biological processes. * Includes the latest developments in the field * Covers the various strategies behind the development and production of a range of key clinically useful compounds * Focuses on the concepts and ideas of why compounds are developed as pharmaceuticals * Provides many examples and problems Invaluable to all students of chemistry, medicinal and pharmaceutical chemistry, pharmacy and pharmacology. Will also be of interest to researchers and professionals needing a concise, up-to-date account of this subject.Trade Review"...explains the synthesis and applications of peptides, proteins, nucleic acids, and oligosaccharides as therapeutic agents..." (SciTech Book News, Vol. 26, No. 2, June 2002) "...an excellent introduction to biomacromolecular drugs..." (Chemistry in Britain, July 2002) "...a very good value...a useful addition to the personal library of many biomedical and pharmaceutical scientistscould serve as a textbook or as supplemental reading.... This book...should be in the holdings of academic and pharmaceutical industry libraries." (Journal of Medicinal Chemistry, Vol. 45, No. 19, 2002) "...a welcome addition to the library of any pharmacy student, chemistry instructor, or laboratory researcher." (The Annals of Pharmacotherapy, Vol. 36, October 2002) "...this is an excellent book..." (Organic Process Research and Development) "...readable and interesting...recommended..." (Angewandte Chemie International Edition, Vol. 41, No. 20, 2002) "...many interesting snippets..." (Chemistry & Industry, 2 December 2002)Table of ContentsIntroduction Endogenous Peptides and Proteins Modification of Endogenous Peptides and Proteins The Immune System Oligonucleotides Oligosaccharides Appendix Index

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Book SynopsisModern Polyester Polymers provides an overview of the family of polyester polymers which comprise an important group of plastics that span the range of commodity polymers to engineering resins. It describes the preparation, properties and applications of polyesters.Trade Review"…a very informative book." (IEEE Electrical Insulation Magazine, March/April 2006) "…for those involved in research or in manufacturing or polyester processing, this book will be essential.” (E-STREAMS, August 2004) "...examines the chemistry and technology of polyester and copolyesters and illustrates the diversity and importance of these materials..." (Materials World, Thursday 1 January 2004) "...successful in presenting and discussing its technical topics...an excellent collection of data...an essential and invaluable resource..." (Materials World, Vol 12(8), August 2004) “…informative…written clearly in a consistent style…should be a key acquisition for any research chemist seeking to investigate polyesters…” (Applied Organometallic Chemistry, Vol.19, No.1, January 2005)Table of ContentsContributors. Series Preface. Preface. About the Editors. I HISTORICAL OVERVIEW. 1 The Historical Development of Polyesters (J. Eric McIntyre). 1 Introduction. 2 Alkyd and Related Resins. 3 Fibres from Partially Aromatic Polyesters. 3.1 Early Work Leading to Poly(ethylene Terephthalate). 3.2 Spread of Polyester Fibre Production. 3.3 Intermediates. 3.4 Continuous Polymerisation. 3.5 Solid-phase Polymerisation. 3.6 End-use Development. 3.7 High-speed Spinning. 3.8 Ultra-fine Fibres. 4 Other Uses for Semi-aromatic Polyesters. 4.1 Films. 4.2 Moulding Products. 4.3 Bottles. 5 Liquid-crystalline Polyesters. 6 Polyesters as Components of Elastomers. 7 Surface-active Agents. 8 Absorbable Fibres. 9 Polycarbonates. 10 Natural Polyesters. 10.1 Occurrence. 10.2 Poly(β-hydroxyalkanoate)s. 11 Conclusion. References. II POLYMERIZATION AND POLYCONDENSATION. 2 Poly(ethylene Terephthalate) Polymerization – Mechanism, Catalysis, Kinetics, Mass Transfer and Reactor Design (Thomas Rieckmann and Susanne Volker). Notation. 1 Introduction .35 2 Chemistry, Reaction Mechanisms, Kinetics and Catalysis. 2.1 Esterification/Hydrolysis. 2.2 Transesterification/Glycolysis. 2.3 Reactions with Co-monomers. 2.4 Formation of Short Chain Oligomers. 2.5 Formation of Diethylene Glycol and Dioxane. 2.6 Thermal Degradation of Diester Groups and Formation of Acetaldehyde. 2.7 Yellowing. 2.8 Chemical Recycling. 2.9 Conclusions. 3 Phase Equilibria, Molecular Diffusion and Mass Transfer. 3.1 Phase Equilibria. 3.2 Diffusion and Mass Transfer in Melt-phase Polycondensation. 3.3 Diffusion and Mass Transfer in Solid-state Polycondensation. 3.4 Conclusions. 4 Polycondensation Processes and Polycondensation Plants. 4.1 Batch Processes. 4.2 Continuous Processes. 5 Reactor Design for Continuous Melt-phase Polycondensation. 5.1 Esterification Reactors. 5.2 Polycondensation Reactors for Low Melt Viscosity. 5.3 Polycondensation Reactors for High Melt Viscosity. 6 Future Developments and Scientific Requirements. Acknowledgements . References. 3 Synthesis and Polymerization of Cyclic Polyester Oligomers (Daniel J. Brunelle). 1 Introduction. 2 History. 3 Preparation of Polyester Cyclic Oligomers from Acid Chlorides. 4 Polyester Cyclic Oligomers via Ring–Chain Equilibration (Depolymerization). 5 Mechanism for Formation of Cyclics via Depolymerization. 6 Polymerization of Oligomeric Ester Cyclics. 7 Conclusions. References. 4 Continuous Solid-state Polycondensation of Polyesters (Brent Culbert and Andreas Christel). 1 Introduction. 2 The Chemical Reactions of PET in the Solid State. 2.1 Basic Chemistry. 2.2 Mechanism and Kinetics. 2.3 Parameters Affecting SSP. 3 Crystallization of PET. 3.1 Nucleation and Spherulite Growth. 3.2 Crystal Annealing. 4 Continuous Solid-state Polycondensation Processing. 4.1 PET-SSP for Bottle Grade. 4.2 Buhler PET-SSP Bottle-grade Process. 4.3 Process Comparison. 4.4 PET-SSP for Tyre Cord. 4.5 Other Polyesters. 5 PET Recycling. 5.1 PET Recycling Market. 5.2 Material Flow. 5.3 Solid-state Polycondensation in PET Recycling. References . 5 Solid-state Polycondensation of Polyester Resins: Fundamentals and Industrial Production (Wolfgang Goltner). 1 Introduction. 2 Principles. 2.1 Aspects of Molten-state Polycondensation. 2.2 Aspects of Solid-state Polycondensation. 2.3 Physical Aspects. 3 Equipment. 3.1 Batch Process. 3.2 Continuous Process. 3.3 SSP of Small Particles and Powders. 3.4 SSP in the Suspended State. 4 Practical Aspects of the Reaction Steps. 4.1 Crystallization and Drying. 4.2 Solid-state Polycondensation. 5 Economic Considerations. 6 Solid-state Polycondensation of Other Polyesters. 7 Conclusions. References. III TYPES OF POLYESTERS 6 New Poly(Ethylene Terephthalate) Copolymers (David A. Schiraldi). 1 Introduction. 2 Crystallinity and Crystallization Rate Modification. 2.1 Amorphous Copolyesters of PET. 2.2 Increased Crystallization Rates and Crystallinity in PET .3 PET Copolymers with Increased Modulus and Thermal Properties. 3.1 Semicrystalline Materials. 3.2 Liquid Crystalline Copolyesters of PET. 4 Increased Flexibility Copolymers of PET. 5 Copolymers as a Scaffold for Additional Chemical Reactions. 6 Other PET Copolymers. 6.1 Textile-related Copolymers. 6.2 Surfaced-modified PET. 6.3 Biodegradable PET Copolymers. 6.4 Terephthalate Ring Substitutions. 6.5 Flame-retardant PET. 7 Summary and Comments. References. 7 Amorphous and Crystalline Polyesters based on 1,4-Cyclohexanedimethanol (S. Richardurner, Robert W. Seymour and John R. Dombroski). Notation. 1 Introduction. 2 1,4-Cyclohexanedimethanol. 3 1,3- and 1,2-Cyclohexanedimethanol: Other CHDM Isomers. 3.1 Definitions: PCT, PCTG, PCTA and PETG. 4 Synthesis of CHDM-based Polyesters. 5 Poly(1,4-Cyclohexylenedimethylene Terephthalate). 5.1 Preparation and Properties. 5.2 Other Crystalline Polymers Based on PCT or CHDM. 5.3 Processing of Crystalline PCT-based Polymers. 5.4 Applications For PCT-based Polymers. 6 GLYCOL-modified PCT Copolyester: Preparation and Properties. 7 CHDM-modified PET Copolyester: Preparation and Properties. 8 Dibasic-acid-modified PCT Copolyester: Preparation and Properties. 9 Modification of CHDM-based Polyesters with Other Glycols and Acids. 9.1 CHDM-based Copolyesters with Dimethyl 2,6-naphthalenedicarboxylate. 9.2 Polyesters Prepared with 1,4-Cyclohexanedicarboxylic Acid. 9.3 CHDM-based Copolyesters with 2,2,4,4-tetramethyl-1,3-cyclobutanediol. 9.4 CHDM-based Copolyesters with Other Selected Monomers. Acknowledgments. References. 8 Poly(Butylene Terephthalate) (Robert R. Gallucci and Bimal R. Patel). 1 Introduction. 2 Polymerization of PBT. 2.1 Monomers. Acid. 2.2 Catalysts. 2.3 Process Chemistry. 2.4 Commercial Processes. 3 Properties of PBT. 3.1 Unfilled PBT. 3.2 Fiberglass-filled PBT. 3.3 Mineral-filled PBT. 4 PBT Polymer Blends. 4.1 PBT–PET Blends. 4.2 PBT–Polycarbonate Blends. 4.3 Impact-modified PBT and PBT–PC Blends. 4.4 PBT Blends with Styrenic Copolymers. 5 Flame-retardant Additives. 6 PBT and Water. 7 Conclusions. References. 9 Properties and Applications of Poly(Ethylene 2,6-naphthalene), its Copolyesters and Blends (Doug D. Callander). 1 Introduction. 2 Manufacture of PEN. 3 Properties of PEN. 4 Thermal Transitions of PEN. 5 Comparison of the Properties of PEN and PET. 6 Optical Properties of PEN. 7 Solid-state Polymerization of PEN. 8 Copolyesters. 8.1 Benefits of Naphthalate-modified Copolyesters. 8.2 Manufacture of Copolyesters. 9 Naphthalate-based Blends. 10 Applications for PEN, its Copolyesters and Blends. 10.1 Films. 10.2 Fiber and Monofilament. 10.3 Containers. 10.4 Cosmetic and Pharmaceutical Containers. 11 Summary. References. 10 Biaxially Oriented Poly(Ethylene 2,6-naphthalene) Films: Manufacture, Properties and Commercial Applications (Bin Hu, Raphael M. Ottenbrite and Junaid A. Siddiqui). 1 Introduction. 2 The Manufacturing Process for PEN Films. 2.1 Synthesis of Dimethyl-2,6-naphthalene Dicarboxylate. 2.2 Preparation Process of PEN Resin. 2.3 Continuous Process for the Manufacture of Biaxially Oriented PEN Film. 3 Properties of PEN. 3.1 Morphology of PEN. 3.2 Chemical Stability. 3.3 Thermal Properties. 3.4 Mechanical Properties. 3.5 Gas-barrier Properties. 3.6 Electrical Properties. 3.7 Optical Properties. 4 Applications for PEN Films. 4.1 Motors and Machine Parts. 4.2 Electrical Devices. 4.3 Photographic Films. 4.4 Cable and Wires Insulation. 4.5 Tapes and Belts. 4.6 Labels. 4.7 Printing and Embossing Films. 4.8 Packaging Materials. 4.9 Medical Uses. 4.10 Miscellaneous Industrial Applications. References. 11 Synthesis, Properties and Applications of Poly(Trimethylene Terephthalate) (Hoe H. Chuah). 1 Introduction. 2 Polymerization. 2.1 1,3-Propanediol Monomer. 2.2 The Polymerization Stage. 2.3 Side Reactions and Products. 3 Physical Properties. 3.1 Intrinsic Viscosity and Molecular Weights. 3.2 Crystal Structure. 3.3 Crystal Density. 3.4 Thermal Properties. 3.5 Crystallization Kinetics. 3.6 Non-isothermal Crystallization Kinetics. 3.7 Heat Capacity and Heat of Fusion. 3.8 Glass Transition and Dynamic Mechanical Properties. 3.9 Mechanical and Physical Properties. 3.10 Melt Rheology. 4 Fiber Properties. 4.1 Tensile Properties. 4.2 Elastic Recovery. 4.3 Large Strain Deformation and Conformational Changes. 4.4 Drawing Behavior. 4.5 Crystal Orientation. 5 Processing and Applications. 5.1 Applications. 5.2 Fiber Processing. 5.3 Dyeing. 5.4 Injection Molding. 6 PTT Copolymers. 7 Health and Safety. References. IV FIBERS AND COMPOUNDS. 12 Polyester Fibers: Fiber Formation and End-use Applications (Glen Reese). 1 Introduction. 2 General Applications. 3 Chemical and Physical Structure. 3.1 Melt Behavior. 3.2 Polymer Structure. 3.3 Fiber Geometry. 4 Melt Spinning of PET Fibers. 4.1 Spinning Process Control. 5 Drawing of Spun Filaments. 5.1 Commercial Drawing Processes. 6 Specialized Applications. 6.1 Light Reflectance. 6.2 Low Pill Fibers. 6.3 Deep Dye Fibers. 6.4 Ionic Dyeability. 6.5 Antistatic/Antisoil Fibers. 6.6 High-shrink Fibers. 6.7 Low-melt Fibers. 6.8 Bicomponent (Bico) Fibers. 6.9 Hollow Fibers. 6.10 Microfibers. 6.11 Surface Friction and Adhesion. 6.12 Antiflammability and Other Applications. 7 The Future of Polyester Fibers. References. 13 Relationship Between Polyester Quality and Processability: Hands-on Experience(Wolfgang Goltner). 1 Introduction. 2 Polyesters for Filament and Staple Fiber Applications. 2.1 Spinnability. 2.2 Yarn Break. 3 Polymer Contamination. 3.1 Oligomeric Contaminants. 3.2 Technological Aspects. 3.3 Thermal, Thermo-oxidative and Hydrolytic Degradation. 3.4 Insoluble Polyesters. 3.5 Gas Bubbles and Voids. 3.6 Dyeability. 4 Films. 4.1 Surface Properties. 4.2 Streaks. 4.3 Processability. 5 Bottles . 5.1 Processing. 5.2 The Quality of Polyester Bottle Polymer. 6 Other Polyesters. 7 Conclusions. References . 14 Additives for the Modification of Poly(ethylene Terephthalate) to Produce Engineering-grade Polymer (John Scheirs). 1 Introduction. 2 Chain Extenders. 2.1 Pyromellitic Dianhydride. 2.2 Phenylenebisoxazoline. 2.3 Diepoxide Chain Extenders. 2.4 Tetraepoxide Chain Extenders. 2.5 Phosphites Chain Extension Promoters. 2.6 Carbonyl Bis(1-caprolactam). 3 Solid-stating Accelerators. 4 Impact Modifiers (Tougheners). 4.1 Reactive Impact Modifiers. 4.2 Non-reactive Impact Modifiers (Co-modifiers) . 4.3 Theory of Impact Modification of PET. 5 Nucleating Agents. 6 Nucleation/Crystallization Promoters. 7 Anti-hydrolysis Additives. 8 Reinforcements. 9 Flame Retardants. 10 Polymeric Modifiers for PET. 11 Specialty Additives. 11.1 Melt Strength Enhancers. 11.2 Carboxyl Acid Scavengers. 11.3 Transesterification Inhibitors. 11.4 Gloss Enhancers. 11.5 Alloying (Coupling) Agents. 11.6 Processing Stabilizers. 12 Technology of Commercial PET Engineering Polymers. 12.1 Rynite. 12.2 Petra. 12.3 Impet. 13 Compounding Principles for Preparing Engineering-grade PET Resins. 14 Commercial Glass-filled and Toughened PET Grades. 15 ‘Supertough’ PET. 16 Automotive Applications for Modified PET. References. 15 Thermoplastic Polyester Composites (Andrew E. Brink). 1 Introduction. 2 Poly(ethylene Terephthalate). 2.1 Crystallization of Poly(ethylene Terephthalate). 2.2 Advantages of Poly(ethylene Terephthalate). 3 Comparison of Thermoplastic Polyesters. 3.1 Poly(butylene Terephthalate). 3.2 Poly(1,4-cyclohexylenedimethylene Terephthalate). 3.3 Poly(trimethylene Terephthalate). 4 Composite Properties. 4.1 Kelly–Tyson Equation. 4.2 Interfacial Shear Strength – The Importance of Sizing. 4.3 Carbon Fiber Reinforcements. 5 New Composite Applications. References. V DEPOLYMERIZATION AND DEGRADATION. 16 Recycling Polyesters by Chemical Depolymerization (David D. Cornell). 1 Introduction. 2 Chemistry. 3 Background. 4 Technology for Polyester Depolymerization . 5 Commercial Application. 6 Criteria for Commercial Success. 7 Evaluation of Technologies. 7.1 Feedstock. 7.2 Capital. 8 Results. 9 Conclusions. 10 Acknowledgement and disclaimer. References. 17 Controlled Degradation Polyesters (F. Glenn Gallagher). 1 Introduction. 2 Why Degradable Polymers? 3 Polymer Degradation. 4 Degradable Polyester Applications. 4.1 Medical. 4.2 Aquatic. 4.3 Terrestrial. 4.4 Solid Waste. 5 Selecting a Polymer for an Application. 5.1 Understand Application Requirement for a Specific Location. 5.2 Degradation Testing Protocol including Goal Degradation Product. 5.3 Lessons from Natural Products. 6 Degradable Polyesters. 6.1 Aromatic Polyesters. 6.2 Aliphatic Polyesters. 6.3 Copolyesters of Terephthalate to Control Degradation. 7 Conclusions. References. 18 Photodegradation of Poly(ethylene Terephthalate) and Poly(ethylene/1,4-Cyclohexylenedimethylene Terephthalate) (David R. Fagerburg and Horst Clauberg ). 1 Introduction. 2 Weather-induced Degradation. 2.1 Important Climate Variables. 2.2 Artificial Weathering Devices. 3 Recent Results for Degradation in PECT. 3.1 Coloration. 3.2 Loss of Toughness. 3.3 Depth Profile of the Damage. 4 Degradation Mechanisms in PET and PECT. 5 Summary. References and Notes. VI LIQUID CRYSTAL POLYESTERS. 19 High-performance Liquid Crystal Polyesters with Controlled Molecular Structure (Toshihide Inoue and Toru Yamanaka). 1 Introduction – Chemical Structures and Liquid Crystallinity. 2 Experimental. 2.1 Synthesis of Polyarylates. 2.2 Preparation of Fibers. 2.3 Preparation of Specimens. 3 Measurements. 3.1 Flexural Modulus. 3.2 Dynamic Storage Modulus. 3.3 Anisotropic Melting Temperature and Clearing Point. 3.4 Melting Temperature and Glass Transition Temperature. 3.5 Orientation Function of Nematic Domains. 3.6 Relative Degree of Crystallinity. 3.7 Morphology. 3.8 Heat Distortion Temperatures. 4 Results and Discussion. 4.1 Moduli of As-spun Fibers. 4.2 Moduli of Injection Molded Specimens. 4.3 Heat Resistance. 4.3.1 Glass Transition Temperature. 4.3.2 Heat Distortion Temperature. 5 Conclusions. 6 Acknowledgement. References. 20 Thermotropic Liquid Crystal Polymer Reinforced Polyesters (Seong H. Kim). 1 Introduction. 2 PHB/PEN/PET Mechanical Blends. 2.1 The Liquid Crystalline Phase. 2.2 Thermal behavior. 2.3 Mechanical properties. 2.4 Transesterification. 3 Effect of a catalyst on the compatibility of LCP/PEN Blends. 3.1 Mechanical property improvement. 3.2 Dispersion of LCP in PEN. 3.3 Heterogeneity of the blend. 4 Thermodynamic miscibility determination of TLCP and polyesters. 5 Crystallization kinetics of LCP with polyesters. 5.1 Non-isothermal crystallization dynamics. 5.2 Isothermal crystallization dynamics. 6 Conclusions. 7 Acknowledgements. References. VII UNSATURATED POLYESTERS. 21 Preparation, Properties and Applications of Unsaturated Polyesters (Keith G. Johnson and Lau S. Yang ). 1 Introduction. 2 Preparation of Unsaturated Polyester Resins. 2.1 Three Types of Unsaturated Polyester Resin Products. 3 Properties of Unsaturated Polyester Resins. 3.1 Chemical Constituents. 3.2 Additives. 3.3 Fillers. 3.4 Reinforcements. 4 Applications of Unsaturated Polyester Resins. 4.1 Marine. 4.2 Construction. 4.3 Transportation. 5 Future Developments. References. 22 PEER Polymers: New Unsaturated Polyesters for Fiber-reinforced Composite Materials (Lau S. Yang). 1 Introduction. 2 Experimental. 2.1 Materials. 2.2 General Procedure for the Preparation of Unsaturated Polyester Resin from a Polyether Polyol . 2.3 A Typical Example of the Preparation of Cured Polyesters. 2.4 Other Examples of Cured Polyester Processes. 3 Results and Discussion . 3.1 Ether Cleavage Reaction Leading to Poly(Ether Ester) Resins. 3.2 Reaction Conditions and Mechanisms. 3.3 The Early Product and Strong-acid Catalysis Development. 3.4 Liquid properties of PEER Resins. 3.5 Physical properties of Cured PEER Resins. 4 Applications. 5 Acknowledgements. References. Index.

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Book SynopsisWritten by top researchers in the field, this new edition of a best--selling title is still the only one on this topic on the market. Includes 20% new material and a new chapter on novel surfactants, including cleavable surfactants, now very widely used in fabric conditions as are more easily degradable (more environmentally friendly.Trade Review"I highly recommend Sufactants and Polymers in Aqueous Solution..." (Polymer News)Table of ContentsPreface to the Second Edition. Preface to the First Edition. Introduction to Surfactants. Surfactant Micellization. Phase Behaviour of Concentrated Surfactant Systems. Physicochemical Properties of Surfactants and Polymers Containing Oxyethylene Groups. Mixed Micelles. Microemulsions. Intermolecular Interactions. Colloidal Forces. Polymers in Solution. Regular Solution Theory. Novel Surfactants. Surface Active Polymers. Surfactant-Polymer Systems. Surfactant-Protein Mixtures. An Introduction to the Rheology of Polymer and Surfactant Solutions. Surface Tension and Adsorption at the Air-Water Interface. Adsorption of Surfactants at Solid Surfaces. Wetting and Wetting Agents, Hydrophobization and Hydrophobizing Agents. Interaction of Polymers with Surfaces. Foaming of Surfactant Solutions. Emulsions and Emulsifiers. Microemulsions for Soil and Oil Removal. Chemical Reactions in Microheterogeneous Systems. Appendices. Index.

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Book SynopsisPresents the theory and application of the subject, describing how engineers can use models to design and simulate process equipment. The text includes numerous examples based on existing systems, and a disk containing programs that solve problems outlined in the book.Table of ContentsMOLECULAR DIFFUSION. Preliminary Concepts. The Maxwell-Stefan Relations. Fick's Law. Estimation of Diffusion Coefficients. Solution of Multicomponent Diffusion Problems: The LinearizedTheory. Solution of Multicomponent Diffusion Problems: EffectiveDiffusivity Methods. INTERPHASE TRANSFER. Mass Transfer Coefficients. Film Theory. Unsteady-State Mass Transfer Models. Mass Transfer in Turbulent Flow. Simultaneous Mass and Energy Transfer. DESIGN. Multicomponent Distillation: Mass Transfer Models. Multicomponent Distillation: Efficiency Models. Multicomponent Distillation: A Nonequilibrium Stage Model. Condensation of Vapor Mixtures. Postface. Exercises. Appendices. References. Indexes.

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Book SynopsisFunctional genomics is the use of genetic information to design drugs. The ability to gather genetic data in the form of complete genetic sequences for certain organisms, has accelerated to astonishing speeds, reflecting the equally astonishing growth of information-gathering technologies.Trade Review"It does successfully convey to the reader areas of controversy" (Microbiology Today, November 2001) "there are a number of nuggets in the book that make it worth a browse." (Pharmaceutical Physician, December 2001) "I found this book fun to read." (Biochemistry & Molecular Biology Education, No.29 2001) "Contributors...present 17 papers and the discussions they generated at the symposium." (SciTech Book News, Vol. 25, No. 4, December 2001)Table of ContentsIntroduction (J. Venter). Electrophoresis-Based Fluorescent Dideoxy-Terminator Sequencing (J. Efcavitch). Genomic Impact on Pharmaceutical Development (J. Venter). From Transcription Regulation to Cell Cycle Checkpoint (R. Cai, et al.). Mass Spectrometry Resurrects Protein-Approaches in Functional Genomics (M. Mann). A Clinical Molecular Scanner to Study Human Proteome Complexity (D. Hochstrasser, et al.). From Proteomics to Functional Analysis (J. van Oostrum, et al.). Microbial Genome Sequencing: New Insights into Physiology and Evolution (C. Fraser). Pharmacogenetics and Pharmacogenomics in the Discovery and Development of Medicines (A. Roses). Mutagenesis and Genomics in the Mouse: Towards Systematic Studies of Mammalian Gene Function (S. Brown). Biological Annotation of the Drosophila Genome Sequence (G. Rubin). Applications of High-Density Oligonucleotide Arrays (R. Lipshutz). Plasmodium Falciparum: From Genomic Sequence to Vaccines and Drugs (S. Hoffman & D. Carucci). Functional Analysis of the Yeast Genome by Precise Deletion and Parallel Phenotypic Characterization (E. Winzeler, et al.). Patenting Genes and Gene Therapy: Legal and Ethical Aspects (J. Straus). Ethical Issues: From Genome to Therapy (D. Magnus). The Impact of Genomics on Drug Discovery (P. Goodfellow). From Genome to Therapy: Industry Perspective (P. Herrling). Final General Discussion. Indexes.

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Book SynopsisPost Genomics Drug Discovery and Research explores and discusses some of the most important topics in post-genomics life and biopharmaceutical sciences. It provides an introduction to the field, outlining examples of many techniques currently used, as well as those still under development, which are important for the research of biopharmaceutical discovery in the post-genomics era. Integrates several developing and cutting-edge technologies and methods like bioinformatics, experimental therapeutics, and molecular recognition Includes discussion on topics such as: computer-aided ligand design; peptide and protein chemistry and synthesis; synthesis of active natural products; and the use of emerging technologies like proteomics, nanotechnology, or bioengineering. Trade Review"A valuable resource for scientists … Chapters in each section are filled with in-depth biological and chemical data and, importantly, include worked examples of drugs identified from these approaches." (The Biochemist, October 2008) "..the book achieves the objective of the Editor in providing a useful tool and reference for scientists concerned with state-of-the-art postgenomic drug discovery…this book will be of interest to medicinal chemistry, as well as to other concerned with developing new drug products." (Journal of Medicinal Chemistry, January 2008)Table of ContentsFOREWORD. INTRODUCTION. CONTRIBUTORS. PART I. COMPUTATIONAL AND STRUCTURAL APPROACHES IN DRUG DISCOVERY. CHAPTER 1. MOLECULAR DOCKING AND STRUCTURE-BASED DESIGN (P. Therese Lang, University of California, San Francisco, CA; Tiba Aynechi, University of California, San Francisco, CA; Demetri Moustakas, University of California, Berkeley, CA; Brian Shoichet, Irwin D. Kuntz,* University of California, San Francisco, CA; Natasja Brooijmans, University of California, San Francisco, CA; and Connie M. Oshiro, Roche, Palo Alto, CA). CHAPTER 2. RECENT ADVANCES IN DRUG DISCOVERY RESEARCH USING STRUCTURE-BASED VIRTUAL SCREENING TECHNIQUES: EXAMPLES OF SUCCESS FOR DIVERSE PROTEIN TARGETS (Sutapa Ghosh (Burnham Institute for Medical Research La Jolla, CA), Aihua Nie (Burnham Institute for Medical Research La Jolla, CA), Jing An (Burnham Institute for Medical Research La Jolla, CA), and Ziwei Huang* (University of California, San Diego; Burnham Institute for Medical Research La Jolla, CA). CHAPTER 3. VIRTUAL SCREENING IN DRUG DISCOVERY (Malcolm J. McGregor, Zhaowen Luo, and Xuliang Jiang* (Serono Research Institute, Rockland, MA). CHAPTER 4. COMPUTER-AIDED DRUG DESIGN (Grace Shiahuy Chen, Providence University, Shalu, Taiwan, Republic of China and Ji-Wang Chern,* National Taiwan University, Taipei, Taiwan, Republic of China). CHAPTER 5. FOCUSED LIBRARY DESIGN BASED ON HIT AND TARGET STRUCTURES: METHOD AND APPLICATION IN DRUG DISCOVERY (Weiliang Zhu (Shanghai Institute ofMateriaMedica, Chinese Academy of Sciences, Shanghai, P.R. China), Jian Li (Shanghai Institute ofMateriaMedica, Chinese Academy of Sciences, Shanghai, P.R. China), Zhen Gong (Shanghai Institute ofMateriaMedica, Chinese Academy of Sciences, Shanghai, P.R. China), Hong Liu (Shanghai Institute ofMateriaMedica, Chinese Academy of Sciences, Shanghai, P.R. China), and Hualiang Jiang* (Shanghai Institute ofMateriaMedica, Chinese Academy of Sciences, Shanghai, P.R. China, East China University of Science and Technology, Shanghai, P.R. China). PART II. CHEMICAL AND SYNTHETIC APPROACHES IN DRUG DISCOVERY. CHAPTER 6. BEYOND NATURAL PRODUCTS: SYNTHETIC ANALOGUES OF BRYOSTATIN 1 (Paul A. Wender*, Jeremy L. Baryza, Michael K. Hilinski, Joshua C. Horan, Cindy Kan, and Vishal A. Verma (Stanford University, Stanford, CA). CHAPTER 7. THE PROMISES AND PITFALLS OF SMALL-MOLECULE INHIBITION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) (Amanda C. Nottbohm and Paul J. Hergenrother* (University of Illinois at Urbana-Champaign, Urbana, IL). CHAPTER 8. CYCLIC ADP-RIBOSE ANALOGUES WITH MINIMAL STRUCTURE: SYNTHESIS AND CALCIUM-RELEASE ACTIVITY (Lihe Zhang* (Peking University, Beijing, P.R. China) and Andreas H. Guse (University Hospital Hamburg—Eppendorf, Institute of Biochemistry and Molecular Biology, Hamburg, Germany). CHAPTER 9. EVALUATION OF NEUROIMMUNOPHILIN LIGANDS (Junhai Xiao, Aihua Nie, and Song Li* (Beijing Institute of Pharmacology and Toxicology, Beijing, P.R. China). CHAPTER 10. CHIRAL DRUGS AND THE ASSOCIATED ASYMMETRIC SYNTHESIS (Jiange Zhang (Zhengzhou University, Zhengzhou, P.R. China) and Guoqiang Lin* (Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P.R. China). CHAPTER 11. ALPHA-HELIX MIMETICS IN DRUG DISCOVERY 281 Hang Yin, Gui-In Lee, and Andrew D. Hamilton* Yale University, New Haven, CT CHAPTER 12. BASIC AND TRANSLATIONAL RESEARCH OF CHEMOKINE LIGANDS AND RECEPTORS AND DEVELOPMENT OF NOVEL THERAPEUTICS (Won-Tak Choi, University of Illinois at Urbana-Champaign, Urbana, IL; Yohichi Kumaki, Raylight Corporation, Chemokine Pharmaceutical Inc., La Jolla, CA; I. M. Krishna Kumar, Burnham Institute for Medical Research, La Jolla, CA; Jing An, Burnham Institute for Medical Research, La Jolla, CA; Douglas D. Richman, Department of Molecular Pathology, University of California, San Diego, CA; Joseph G. Sodroski, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; and Ziwei Huang,* University of Illinois at Urbana-Champaign, Urbana, IL, Burnham Institute for Medical Research, La Jolla, CA; Department of Molecular Pathology, University of California, San Diego, CA). CHAPTER 13. RESEARCH PROGRESS IN PROTEIN POST-TRANSLATIONAL MODIFICATION (Jia Hu, Yanting Guo, and Yanmei Li,* Tsinghua University, Beijing, P.R. China). CHAPTER 14. CONTROLLED RELEASE OFANTIBIOTICS ENCAPSULATED IN NANOPOROUS SOL–GEL MATERIALS WITH TUNABLE PORE PARAMETERS (Houping Yin, Laura Zheng, and Yen Wei,* Drexel University, Philadelphia, PA). PART III. BIOLOGICAL APPROACHES AND TRANSLATIONAL RESEARCH IN DRUG DISCOVERY. CHAPTER 15. RETINOIC ACID AND ARSENIC TRIOXIDE TREATMENT IN ACUTE PROMYELOCYTIC LEUKEMIA: A MODEL OF ONCOPROTEIN TARGETED THERAPY (Jian-Hua Tong, Sai-Juan Chen, and Zhu Chen,* Shanghai Institute of Hematology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China). CHAPTER 16. 2-CHLORODEOXYADENOSINE (CLADRIBINE): RATIONAL DEVELOPMENT OFA NOVEL CHEMOTHERAPEUTIC AGENT (Howard B. Cottam and Dennis A. Carson,* Moores Cancer Center, University of California, San Diego, CA). CHAPTER 17. APOPTOSIS-BASED DRUG DISCOVERY FOR CANCER (John C. Reed*, Dayong Zhai, Marc Hyer, and Kate Welsh, Burnham Institute for Medical Research, La Jolla, CA). CHAPTER 18. MECHANISM-BASED DEVELOPMENT OF MEMANTINE AS A THERAPEUTIC AGENT IN TREATING ALZHEIMER’S DISEASE AND OTHER NEUROLOGIC DISORDERS: LOW-AFFINITY, UNCOMPETITIVE ANTAGONISM WITH FAST OFF-RATE (Huei-Sheng Vincent Chen*, and Stuart A. Lipton,* Burnham Institute for Medical Research, La Jolla, CA; University of California, San Diego, CA). CHAPTER 19. BRIDGING BENCH TO CLINIC: ROLES OFANIMAL MODELS FOR POST-GENOMICS DRUG DISCOVERY ON METABOLIC DISEASES (Chi-Wai Wong and Ling Chen,* Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, P.R. China). CHAPTER 20. STEM CELL RESEARCH AND APPLICATIONS FOR HUMAN THERAPIES (Prithi Rajan, Kook In Park, Vaclav Ourednik, Jean Pyo Lee, Jamie Imitola, Franz-Joseph Mueller, Yang D. Teng, and Evan Snyder,* Burnham Institute for Medical Research, La Jolla, CA). INDEX.

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Book SynopsisSurfactants are catalysts that work by effecting or changing the surface of a material. Used in a wide range of industries, notably in the processing of soaps and detergents, surfactants have attracted a great deal of interest recently from environmental agencies concerned with effects of pollutants.Table of ContentsSample Preparation, Isolation and Characterization of Surfactants and Determination of Surface-Active Ions. Elementary Composition and Structural Characteristics: Controlled Degradation. Separation of Mixtures of Surfactants. Selected Methods for the Quantitative Analysis of Surfactants. Spectrometry. Electrometry and Other Physical and Physico-Chemical Methods. References. Index.

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Book SynopsisAn introduction and guide to the analysis of mineral type materials and products using the fused, cast bead technique. Coverage includes spectrometric parameters and the analytical procedures for a wide range of substances, essential laboratory equipment and its correct use, processes involved in ignition and decomposition loss by fusion and their chemistry.Table of ContentsApparatus and Equipment. Determination of Non-XRF Elements. Loss on Ignition. Decomposition of Samples by Fusion. Selection of Instrument Parameters. Element Line Selection. The Standard Procedure. Calibration. Presentation of the Sample Bead and Completion of theAnalysis. Routine Techniques for Material Types. Procedures for Silica/Alumina Range Materials. Procedures for Calcium-Rich Materials. Procedures for Magnesium-Rich Materials. Procedures for Zircon-Bearing Materials. Procedures for Various Oxides and Titanates. Procedures for Glasses, Glazes and Frits. Procedures for Reduced Materials. Procedures for Samples of Unknown Composition. Appendices. Index.

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Book SynopsisIn recent years the use of liquid--liquid extraction equipmenthas attracted widespread interest from all major chemicalengineering, petroleum and pharmaceutical companies as well asuniversity-based scientists and engineers. Liquid--LiquidExtraction Equipment presents : * a critical analysis of all available information, includingpractical recommendations * new ideas on performance enhancement and equipmentselection * an up-to-date review of research results on equipmentperformance * illustrations of present understanding using well-knownequipment * a concise survey of past, present and forthcomingprocedures The combination of the historical aspects of the subject, withextensive references and illustrations, make this a uniqueinformation source. All researchers, in industry and academia,using this type of equipment will find Liquid--LiquidExtraction Equipment an authoritative reference work and a solidbasis for future research projects.Table of ContentsPartial table of contents: Historical Background (M. Hampe, et al.). Recommended Systems for Liquid Extraction Studies (H.-J. Bart, et al.). Rate Coefficients in Liquid-Liquid Extraction Systems (M.Slater). General Hydrodynamic Design Basis for Columns (T.Mí&sbreve;ek). Computational Procedures for Column Simulation and Design (L.Steiner). Population Balance Based Modelling of Solvent Extraction Columns(C. Gourdon, et al.). Packed Columns (G. Stevens). Rotating Disc Contactors (W. Korchinsky). Pulsed Sieve-Plate Columns (H. Haverland & M. Slater). Mixers (J. Godfrey). Gravity Settlers (S. Hartland & S. Jeelani). Centrifugal Extractors (E. Blass). Index.

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Book SynopsisDivided into two parts, this work begins with preliminary comments regarding the definition of "surface phases" and briefly describes the basics of two-dimensional crystallography, including background information about the formation and characterization of surface phases on silicon.Table of ContentsPRELIMINARY COMMENTS. Preliminary Comments. REVIEW OF SURFACE PHASES ON SILICON. Atomically-Clean Silicon Surfaces. Adsorbates on Silicon Surfaces. Supplements. Index.

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Book SynopsisSpray atomization and deposition is a fast growing materials processing technique. Its development has encompassed process design, process modeling, new materials and automatic control.Trade Review"...[the authors] have presented the available information...in a cogent manner to make this excellent volume a a Hand Booka on the subject.." ----Journal of Materials Processing, Vol 99, 2000Table of ContentsOverview. Historical Perspective and Current Status of Development. Atomization. Heat Transfer and Solidification of Droplets. Deposition. Spray Deposition Processing of Composites. Physical and Mechanical Properties of Spray-depositedMaterials. Diagnosis and Characterization Techniques. References. Indexes.

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Book SynopsisCellulose is the most abundant organic polymer on earth. In solution, cellulose derivatives can form liquid crystals which take on characteristics of the solid state with unique optical and physico-mechanical properties. The author presents an overview of modern developments in the physical chemistry of solutions of cellulose and its derivatives. Physical Chemistry of Non-aqueous Solutions of Cellulose and Its Derivatives discusses: * how experimental data and computer simulation can give insight into the factors which influence the interaction of solvent and solute * how phase transitions in solution can be predicted from the solvency of non aqueous solvents for oellulose and its derivatives * the methods for obtaining thermodynamic parameters for solvation in non-aqueous solvents * the rheological properties of lyotropic liquid crystals. The Wiley Series in Solution Chemistry fills the increasing need to present authoritative comprehensive and fully up-to-date accTrade Review"...would be recommended for polymer science libraries...moreover it would be of interest for research personnel in those industries that have an interest in developing polymer products from cellulose and its derivatives." --Macromolecular Chemistry & Physics, 23rd October 2000Table of ContentsPhase Equilibria and Liquid Crystalline Order in Solutions of Cellulose and Its Derivatives. Influence of the Solvent on the Equilibrium and Kinetic Rigidity of the Molecular Chain of Cellulose and Its Derivatives in Solution. Thermochemistry of Dissolution of Cellulose in Non-aqueous Solvents. Solvation of Cellulose and Its Derivatives in Non-aqueous Solutions. Mathematical Models of Cellulose and Its Derivatives in Solution. Rheological Behaviour of Lyotropic LC Systems Based on Cellulose and Its Derivatives. Index.

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Book SynopsisDrawing on his own extensive experience, Jones provides rules of thumb essential for the new engineer in industry.Table of ContentsBasic Process Engineering Principles. Common Systems in Chemical Processes. Equipment--Vessels. Pumps. Compressors. Heat Exchangers. Fired Heaters. Process Studies and Economic Analysis. The Process Engineers' Roles in Project Management. Appendices. References. Index.

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Book SynopsisThe first book to provide a comprehensive treatment integrating finite-time thermodynamics and optimal control, giving an overview of important breakthroughs in the last 20 years. It presents a survey of the optimization technique, including the basics of optimal control theory, and the principal thermodynamic concepts and equations.Table of ContentsMathematical Modeling of Thermodynamic Systems. Optimization Methods. Optimal Control Methods. Limiting Possibilities of Heat-Mechanical Systems with One Reservoir. Heat-Exchange Processes with Minimal Dissipation. Optimization and Estimates of the Limiting Possibilities of Heat-Mechanical Systems with a Number of Reservoirs. Limiting Possibilities of Complex Systems with a Number of Heat-Mechanical Systems. Mass Transfer Processes with Minimal Irreversibility. Thermodynamic Analysis of Separation Processes and Chemical Reactions. Commodity Exchange in Economic Systems. Bibliography. Index.

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Book SynopsisThis book covers the current status of fungicide research as well as giving a brief perspective of this field. Its main purpose is to consider the ongoing discovery of new modes of action and approaches for disease control. Problems posed by resistance and by the biological control of fungal diseases will be discussed.Trade Review"This book can be recommended to everybody working or being interested in plant physiology and modern plant protection." ----Journal of Plant Physiology, Vol 156, 2000Table of ContentsImpact of Diseases and Disease Control on Crop Production (H. Dehne& E. Oerke). Fungicide Classes: Chemistry, Uses and Mode of Action. Natural Product-Derived Fungicides as Exepmplified by theAntibiotics (I. Yamaguchi). Fungicide Resistance (S. Kendal & D. Hollomon). The Strobilutin Fungicides (J. Clough & C. Godrey). Biological Control of Fungal Diseases (R. Larkin, et al.). Activators for Systemic Acquired Resistance (I. Yamaguchi). Novel Approaches to Disease Control (K. Yoneyama). Index.

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Book SynopsisAn essential book for all those clinicians and reserachers undertaking clinical trials. It will ensure that all involved in clinical trials undertake their investigation according to standard operating procedures.Table of ContentsClinical Research. Phases of a Clinical Trail. Clinical Trial Design. History and Development of GCP. Good Clinical Practice - What is It? Responsibilities of the Investigator. Standard Operating Procedures. Organisation of Clinical Trials. Abbreviations. SOP 0: Preparation, Approval and Review of SOPs. SOP 1: Study Organisation and Planning. SOP 2: Study Team: Definition of Responsibilities. SOP 3: Study Files and Filing. SOP 4: Local Management Requirements. SOP 5: Review and Validation of the Protocol. SOP 6: Review of Protocol Amendments. SOP 7: Case Report Form (CRF) Review. SOP 8: Investigator's Brochure. SOP 9: Estimation of Patient Numbers. SOP 10: Ethics Committee. SOP 11: Indemnity, Compensation and Insurance. SOP 12: Laboratory. SOP 13: Pre-Study Monitoring Visits. SOP 14: Patient Recruitment and Intention to Enrol. SOP 15: Obtaining Personal Written Informed Consent. SOP 16: Obtaining Informed Consent for Patients Unable to Give Personal Consent. SOP 17: Randomisation and Stratification. SOP 18: Blinding: Codes and Code Breaking. SOP 19: Case Report Form (CRF) Completion. SOP 20: Study Drugs. SOP 21: Monitoring Visits. SOP 22: Adverse Event and Serious Adverse Event Reporting. SOP 23: Nursing Procedures. SOP 24: Clinical Procedures. SOP 25: Trial Report. SOP 26: Archiving. SOP 27: Audits and Inspections. FDA Regulations Concerning Clinical Trials. Index.

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Book SynopsisThe twentieth century has been a great success for modern medicine, and has resulted in the generation of a plethora of drugs to treat most common illnesses. However, in the light of increasing regulatory demands, spiralling costs and diminishing commercial returns, the question of how, when, where and whether to conduct pharmaceutical R&D has profound implications, and not just for those within the pharmaceutical industry. In response to these and other dilemmas, the authors define the processes involved in drug research, and examine the advantages and disadvantages of collaborative methods of drug research, and examine the roles that academia, CROs, small biotechnology companies and research boutiques, and possibly even the virtual research company might play as contractors and collaborators.Table of ContentsThe Pharmaceutical Development Process. The Advantages of Contracts and Collaborations. The Disadvantages of Contracts and Collaborations. The Role of Academic Institutes. The Role of CROs and Small Research Companies. Towards the Virtual Research Company. References. Index.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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Book SynopsisSintering is one of the most important industrial techniques for optimizing the capabilities of different materials and this book deals exclusively with the state-of-the-art on the processing of sintered materials, both metallic and ceramic.Table of ContentsSintered Low-alloy Ferrous Materials. Sintered High-alloy Ferrous Materials. Sintered Copper Alloys. Sintered Aluminium Alloys. Sintered Nickel Alloys. Sintered Titanium and Zirconium Alloys. Sintered Silver and Lead Alloys. Sintered Molybdenum and Tungsten Alloys. Sintered Rare Earth Intermetallics. Sintered Oxide Ceramics. Sintered Non-oxide Ceramics. Sintered Cermets. Applications. Index.

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Book SynopsisQuantitative Molecular Pharmacology and Informatics in Drug Discovery Michael Lutz, Section Head, Cheminformatics Group and Terry Kenakin, Principal Research Scientist, Glaxo Wellcome Research and Development, Research Triangle Park, NC, USA Quantitative Molecular Pharmacology and Informatics in Drug Discovery combines pharmacology, genetics and statistics to provide a complete guide to the modern drug discovery process. The book discusses the pharmacology of drug testing and provides a detailed description of the statistical methods used to analyze the resulting data. Application of genetic and genomic tools for identification of biological targets is reviewed in the context of drug discovery projects. Covering both the theoretical principles upon which the techniques are based and the practicalities of drug discovery, this informative guide. * outlines in step-by-step detail the advantages and disadvantages of each technology and approach and links these to the type of chemicalTrade Review"...a timely and important book..." "I recommend this book to pharmaceutical company statisticians..." --Biometrics, September 2000 "...covers a tremendous amount of ground....I recommend this book to pharmaceutical statisticians..." --Technometrics, 2000Table of ContentsDrug Discovery. Measurement of Drug Affinity. Efficacy. Pharmacological Assays Used in Screening for Therapeutic Ligands. Finding the Optimal Assay Format for the Chemical Target. Mathematical and Statistical Framework for Problems in Drug Discovery. Statistical Methods for Target Identification and Validation. Experimental Design. Analysis and Interpretation of Data. Index.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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Book SynopsisMomentum, heat and mass transport phenomena can be found everywhere in nature. A solid understanding of the principles of these processes is essential for chemical and process engineers. The second edition of Transport Phenomena builds on the foundation of the first edition which presented fundamental knowledge and practical application of momentum, heat and mass transfer processes in a form useful to engineers. This revised edition includes revisions of the original text in addition to new applications providing a thoroughly updated edition. This updated text includes An introduction to physical transport analysis including units, dimensional analysis and conservation laws. A systematic treatment of fluid flow and heat and mass transport, their similarities and dissimilarities. Theoretical and semi-empirical equations and a condensed overview of practical data. Illustrative problems showing practical applications. A problem section aTable of ContentsIntroduction to Physical Transport Phenomena. Flow Phenomena. Heat Transport. Mass Transport. Notation. Index.

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Book SynopsisTransport Phenomena Second Edition W.J. Beek K.M.K. Muttzall J.W. van Heuven Momentum, heat and mass transport phenomena can be found everywhere in nature. A solid understanding of the principles of these processes is essential for chemical and process engineers.Table of ContentsIntroduction to Physical Transport Phenomena. Flow Phenomena. Heat Transport. Mass Transport. Notation. Index.

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Book SynopsisConsiders the rapid microbiological techniques, which are being increasingly used in industry as alternatives to more conventional methods. In this volume, leading experts from research and industry review the wide variety of approaches that are needed in an industrial setting.Table of ContentsThe use of ATP bioluminescence for the analysis of beer in polyethylene terphthalate (PET) bottles and associated plant; Rapid assessment of the bacterial content of milk by bioluminscent techniques; DEFT: recent developments for food and beverages; The rapid estimation of bacterial counts on meat and poultry by the direct epifluorescent filter technique; Medical and pharmaceutical applications of the direct epifluorescent filter technique (DEFT); The use of image analysis for MIC determination and bioassay; Optimization of automated electrometric methods; Conductance techniques for the detection of contaminants in beer; Electrical methods for water quality testing; A conductance screen for enterobacteriaceae in foods; Electrical screening of powdered dairy products; An inter-laboratory evaluation of an electrometric method for detection of salmonellas in milk products

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Book SynopsisThis book examines the plastic design and behaviour of main frames----both low--rise industrial and agricultural, and multistorey. Representative topics, such as member and frame stability and restraints and connections, are explained in clear and detailed presentations, and will interest practitioners and students alike.Table of ContentsIntroduction; Principles of plastic design; Further considerations in plastic design; Plastic design of beams; Pitched roof portal frame building; Multi-storey buidings; Miscellaneous portals; Multi-span portal frames; Design of agricultural buildings; Performance of agricultural buildings; Two case studies

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Book SynopsisPaper is older than the printing press, and even in its unprinted state it was the great network medium behind the emergence of modern civilization. In the shape of bills, banknotes and accounting books it was indispensible to the economy. As forms and files it was essential to bureaucracy. As letters it became the setting for the invention of the modern soul, and as newsprint it became a stage for politics. In this brilliant new book Lothar Müller describes how paper made its way from China through the Arab world to Europe, where it permeated everyday life in a variety of formats from the thirteenth century onwards, and how the paper technology revolution of the nineteenth century paved the way for the creation of the modern daily press. His key witnesses are the works of Rabelais and Grimmelshausen, Balzac and Herman Melville, James Joyce and Paul Valéry. Müller writes not only about books, however: he also writes about pamphlets, playing cards, papercutting aTrade Review"Balanced and intelligent... Even those who are happy with e-books will be grateful to Muller's publishers for printing White Magic on good, thick, creamy paper and including, at the end, a dozen blank pages, all of which I have covered with untidy, handwritten notes, to make this mechanical mass-produced artifact intimately my own."—New York Review of Books "A richly sprawling history"—Times Literary Supplement "A panoramic literary-historical work reminiscent of Erich Auerbach's Mimesis"—The Washington Post "What a great read! It is a book to warm up the brain on a day of mental fog."—Inside Higher Education "Most of this erudite, engaging work is concerned with the rise of paper and its dominance as civilisation's archive and its role as a 'metaphorical resource': the origin of phrases such as 'a blank page'. As well as being a historical account of the way paper came to permeate every aspect of life, Muller mines European literature for the role paper has played in the stories we tell ourselves."—Sydney Morning Herald "Lothar Müller... tells an alternative history of paper. He argues, convincingly, that paper has been, and continues to be, integral to our civilisation and the modern world. Through a carefully structured sequence of illuminating vignettes, he brings together fascinating facts from across the globe and the centuries to reveal the long-running and fundamental impact of paper on human life, work and culture."—Times Higher Education "Müller's work leaves the reader admiring something that feels magical."—Publishers Weekly "...the tale that Lothar Müller spins in White Magic: The Age of Paper is one that brings paper—as both physical material and a playing field on which the human imagination can run wild—to vivid life. Incorporating a wealth of historical detail, technical information, and critical analysis, Müller makes his account lively and compelling, giving paper a personality and substance that is on par with any words that may appear on it. In his book, paper is not just the silent partner of the printing press. Instead, it is an extremely versatile substance—one whose uses and forms shape human thought and behavior in many ways."—The Nomadic Press "As paper increasingly fades into history, the story of its role and evolution is at risk of being lost, erasing the roadmap that brought us to the digital era. Lothar Müller's White Magic: The Age of Paper goes a long way to averting that fate, going back in time to record and describe in intricate detail how paper came to be, and what it came to be."—South China Morning Post "Consistently readable and highly entertaining, this witty and learned book deftly decouples paper's history from the story of printing to tell new and surprising tales about a medium that continues to pervade our daily life. You'll never look at a blank page in quite the same way again."—Catherine Robson, New York University "This is an absorbing history of paper, fascinating in its detail and magisterial in its scope. Muller writes with the authority of a scholar and the imagination of a poet, filling his book with curious but essential facts and astute perceptions. It is a delight to read."—Jeremy Adler, King's College London "Müller's history of paper is original, engaging and breathtakingly erudite. It explores paper in its materiality, but also as a source of inspiration which has shaped the history of knowledge and creativity. In tracing paper's vital role in the development of human civilisation, the author also argues for its continued importance in the digital age."—Carolin Duttlinger, Wadham College, Oxford "Lothar Müller set out dazzling new insights into the creation of our world, building on Harold Innis’ work on the long and complex emergence of paper. Unique in his White Magic is his subtle blending of cultural and media history with sociological understanding and literary reflexion."—Philippe Despoix, Center of Intermedial Research in Arts, Literatures and Technologies, Université de MontréalTable of ContentsThanks viii PROLOGUE The Microbe Experiment ix PART ONE The Diffusion of Paper in Europe 1 CHAPTER 1 Leaves from Samarkand 3 1.1 The Arab Intermediate Realm 3 1.2 Calligraphy and the Cairo Wastepaper Basket 10 1.3 In Scheherazade’s World 13 1.4 Timur and Suleika 17 CHAPTER 2 The Rustling Grows Louder 22 2.1 The European Paper Mill Boom 22 2.2 Paper, Scholars, and Playing Cards 26 2.3 The Rise of the File: Paper Kings, Chanceries, and Secretaries 31 2.4 The Merchant of Genoa and His Silent Partner 37 2.5 Ragpickers, Writers, and the Pulpit 46 CHAPTER 3 The Universal Substance 52 3.1 Marshall McLuhan and the Pantagruelion of Rabelais 52 3.2 Harold Innis, the Postal System, and Mephisto’s Scrap 61 3.3 The World in a Page: Watermarks, Formats, Colors 70 PART TWO Behind the Type Area 79 CHAPTER 1 The Printed and the Unprinted 81 1.1 The Pitfalls of a Formula: “From Script to Print” 81 1.2 The White Page 85 1.3 “Found among the Papers ...” 89 CHAPTER 2 Adventurers and Paper 94 2.1 Don Quixote, the Print Shop, and the Pen 94 2.2 Picaresque Paper: Simplicius Simplicissimus and the Schermesser 99 2.3 Robinson’s Journal, Ink, and Time 104 CHAPTER 3 Transparent Typography 108 3.1 The Epistolary Novel’s Mimicry of Letter Paper 108 3.2 Laurence Sterne, the Straight Line, and the Marbled Page 115 3.3 The Fragmentation of the Printed Page: Jean Paul, Lichtenberg, and Excerpts 119 PART THREE The Great Expansion 127 CHAPTER 1 The Demons of the Paper Machine 129 1.1 The Mechanization of Sheet-Making 129 1.2 The Loom of Time, the French Revolution, and Credit 140 1.3 Balzac, Journalism, and the Paper Scheme in Lost Illusions 152 1.4 The Secrets of the Scriveners: Charles Dickens and Mr. Nemo 163 1.5 Foolscap and Factory Workers: Herman Melville and the Paper Machine 168 CHAPTER 2 Newsprint and the Emergence of the Popular Press 180 2.1 The Boundless Resource Base 180 2.2 The Newspaper, the Price of Paper, and the Patrioteer 189 2.3 Émile Zola, the Petit Journal, and the Dreyfus Affair 196 CHAPTER 3 Illuminated Inner Worlds 201 3.1 Wilhelm Dilthey, Historism, and Literary Estates 201 3.2 Henry James, Edith Wharton, and the Autograph Hunt 207 3.3 Laterna Magica: Paper and Interiors 215 CHAPTER 4 The Inventory of Modernity 226 4.1 Typewriter Paper, Deckle Edges, and White Space 226 4.2 James Joyce, Newsprint, and Shears 236 4.3 William Gaddis, the Paperwork Crisis, and Punch Cards 242 4.4 Rainald Goetz, the Mystic Writing Pad, and the Smell of Paper 249 EPILOGUE The Analog and the Digital 253 Notes 265 Bibliography 274 Image Credits 292 Index of Names 293

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