Biochemistry Books
Royal Society of Chemistry Detection and Analysis of Microorganisms by Mass
Book SynopsisIn the human body, there are millions of living microorganisms involved in protecting the body from invaders, helping digestion and regulating moods, but there are also harmful pathogens that cause infectious diseases. For instance, the coronavirus (COVID-19) has caused considerable loss of life since its outbreak. Comprehensive analysis and characterization of microbes is of significant importance to understand the function and role of microorganisms, and rapid detection and identification of unknown pathogens are essential in early diagnosis, treatment monitoring and personalized medicine. Mass spectrometry is a technique to ionize molecules and detect the mass-to-charge ratio of the generated ions. The technique is widely used in hospitals for pathogenic bacteria identification, as well as in environmental science and food science for biosafety control. This book summarizes the most recent development of mass spectrometry techniques in microbial analysis, including mass spectrometry-based microbial identification, bacterial antimicrobial resistance study, data mining algorithm development, omics for microbial research, applications in clinical diagnosis, environmental science and food science, and more. It will guide researchers in the field, and those who are about to enter the field, in the most appropriate methods to characterize microbes and enable their detection.Table of ContentsIntroduction of Mass Spectrometry-based Microorganism Detection;MALDI-TOF Mass Fingerprinting for Rapid Identification of Bacteria (Experimental Procedures);MALDI-TOF Mass Fingerprinting for Rapid Identification of Bacteria (Data Analysis and Algorithm Development);Ambient Ionization Mass Spectrometry for Microbial Analysis;Nucleic Acid Amplification Coupling with Mass Spectrometry Detection for Microbial Identification;Proteomics Analysis of Bacteria for Identification and Antimicrobial Resistance Analysis;Metabolomics as a Tool for Phenotypic Characterization and Strain Improvement;Integrated Analysis of Bacteria for Identification, Phenotyping, and AST Using Mass Spectrometry, Machine Learning, and Multi-omics Analysis;Rapid Detection and Evolution of SARS-CoV-2 and Other Viruses with High Resolution Mass Spectrometry;Mass Spectrometry-based Proteomics of Eukaryotes;Mass Spectrometry Imaging in Microbiology;Identification of Microorganisms by Mass Spectrometry in Clinical Microbiology Laboratory;Mass Spectrometry-based Microbial Identification and Profiling for Environmental Science;Mass Spectrometry (MS)-based Bacterial Identification in Food Industry
£160.55
Royal Society of Chemistry Transition Metal-containing Dendrimers in
Book SynopsisThere has been increasing research into designing transition metal-containing dendrimers as innovative materials, especially in the field of biomedicine and pharmaceutical science. They have applications in biosensors and drug-delivery systems, and are now one of the leading classes in the design of therapeutics for drug-resistant diseases. This book introduces readers to a number of classes of metal-containing dendrimers, before moving onto their design and synthesis. Their applications in biomedicine are then discussed, before highlighting future research targets in this growing field. It emphasizes the synthetic strategies to design transition metal-containing dendrimers, and discusses the type of laboratory work used to examine these types of dendrimers in the fields of medicine and pharmacology, including their antimicrobial, anticancer, anti-inflammatory and antiviral activities. Transition Metal-Containing Dendrimers in Biomedicine brings chemistry, biology, pharmaceutical science and medical fields together to design these future materials which will have global benefits.Table of ContentsIntroduction;Antimicrobial Activity of Metal-containing Dendrimers;Anticancer Activity of Metal-containing Dendrimers;Other Therapeutic Applications;Biosensors and Bioimaging
£151.05
Imperial College Press Selected Papers Of Sir Alan Fersht, The:
Book SynopsisThis book compiles a collection of original scientific articles written by Professor Sir Alan Fersht over 40 years of his scientific career. A long-standing icon in the fields of enzymology, protein folding, and protein engineering, Sir Alan Fersht is also one of the world's greatest protein chemists, whose work has been extensively recognized by countless international awards in both chemistry and molecular biology. He has produced a number of classic papers that are cited regularly because of the originality of his work and his insightful analysis. The study of his work on the fusion of physical chemistry and molecular biology provides a course on how to approach the analysis of complex systems in a simple logical manner. His papers are models of clarity, benefitting students of protein chemistry in their understanding of the subject.The beginning of Sir Alan Fersht's career coincided with the birth of modern protein science based on structural biology, which started in earnest momentum in the 1960s. He worked in the then Mecca of molecular biology, the MRC Laboratory of Molecular Biology, and was one of the first protein chemists to exploit the new area of structural biology. The papers are interlaced with personal comments on how each article was important in his career and how he was influenced by the galaxy of legendary scientists in the MRC.Table of ContentsBrief Biographical Introduction; The Early Research Years: Influence of William P Jencks; Enzyme Structure and Mechanism: The Shock of the New; Aminoacyl-tRNA Synthetases and Editing Mechanisms; Protein Engineering; Catalysis, Specificity and Non-covalent Interactions; Structure-Reactivity (Linear-Free-Energy Relationships) in Mutated Proteins; Protein Folding: Stability and Pathway; The Molecular Chaperonin GroEL; Protein Folding Pathways and Φ-Value Analysis; Protein-Protein Interactions; p53 - Protein Stability and Cancer; p53 Structural Studies; Some Reflections on Which to End;
£123.50
Royal Society of Chemistry Metals and Life
Book SynopsisMetals play a vital role in the metabolism of plants and animals and, increasingly, in medicine. This book provides an introduction to the metals essential to life and ligands of biological importance. It considers the uptake of metals, their transport and ultimately their storage, illustrated in particular with the story of iron in the body. It also considers Na, K and Ca ion channels and biomineralisation and covers the key roles that metals and their complexes play in living systems, for example in respiration and photosynthesis. The last chapter (delivered online) considers metal toxicity and deficiency as well as the role that metals play in medicine, looking at both diagnostics and therapy, and in the forefront of inorganic research.Table of ContentsIntroduction Ligands and biological significance Metal uptake - increasing the solubility of iron Metal transport Metal storage Biomineralisation The role of metal-containing proteins in biological processes Some key biological processes Additional online material: Metals in medicine
£24.99
Royal Society of Chemistry G Protein-Coupled Receptors: From Structure to
Book SynopsisG protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins, and even light. Ligands (agonists and antagonists) acting on GPCRs are important in the treatment of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors represent about one third of the actual identified targets of clinically used drugs. The determination of rhodopsin crystal structure and, more recently, of opsin, 1 and 2 adrenergic and A2A adenosine receptors provides both academia and industry with extremely valuable data for a better understanding of the molecular determinants of receptor function and a more reliable rationale for drug design. GPCR structure and function constitutes a hot topic. The book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, is divided into three parts. The first part considers what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details new insights on the link between structure and mechanism and their implications in drug design.Table of ContentsSection I: GPCR crystal structures on the arena; Structure and mechanism of G protein signalling through crystal structures of rhodopsin; Mechanism of receptor activation through the crystal structures of the ligand-free GPCR opsin;Crystal structure of the human ¯2 adrenergic G-protein-coupled receptor; Crystal structure of a ¯ 1 adrenergic G-protein-coupled receptorCrystal structure of a human A2A adenosine receptor bound to an antagonist; Class A GPCRs: Structural analysis of the binding domain of follicle stimulating hormone receptor; Class B GPCRs: Receptor activation involving ligand binding to two receptor domains; Class C GPCRs: Structures of the extracellular regions of metabotropic glutamate receptors; Section II: GPCRs are multifaceted functional machines; G protein-coupled receptor homo- and hetero-dimerization: contribution to pharmacology and function; Detection of heteromers formed by combinations of three different receptors; Cross-talk between ionotropic and metabotropic glutamate receptors; Structural and functional basis of the crosstalk between receptors; GPCRs assemble as oligomers in the membrane, however a monomeric receptor is sufficient for G protein activation; Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors; Molecular basis of agonism revealed by fluorescence resonance energy studies; Metabotropic glutamate receptors: A paradigm of structural and functional receptor complexity; Lipid-protein interactions in GPCR-associated signaling; The role of cholesterol in GPCR signaling; Cholesterol-dependent GPCR signaling efficacy; Modulating receptor function through RAMPs: can they represent drug targets in themselves?; GRK2 Activation by Receptors; GRK2-Dependent Desensitization Downstream of G Proteins; Arrestins as multi-functional signaling adaptors; Enzyme regulation of -Arrestin-dependent signalling and trafficking of GPCRs; Section III: Modelling GPCR structure and function; Analyzing the activation mechanism of GPCRs by biophysical and computational methods; Modelling the activation mechanism of free fatty acid receptor 1; Prediction of opioid receptor oligomerization; Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from molecular dynamics simulations; Quantifying GPCR function; Mathematical modelling of metabotropic glutamate receptors function; Modelling of G-protein-coupled receptor signaling pathways; From Structure to function to drug discovery: the view-point of a medicinal chemist
£161.49
Royal Society of Chemistry Biological Interactions with Surface Charge in
Book SynopsisWhen a biomaterial is placed inside the body, a biological response is triggered almost instantaneously. With devices that need to remain in the body for long periods, such interactions can cause encrustation, plaque formation and aseptic loosening on the surface. These problems contribute to the patient's trauma and increase the risk of death. Electrical properties, such as local electrostatic charge distribution, play a significant role in defining biological interactions, although this is often masked by other factors. This book describes the fundamental principles of this phenomenon before providing a more detailed scientific background. It covers the development of the relevant technologies and their applications in therapeutic devices such as MRSA-resistant fabrics, cardiovascular and urological stents, orthopaedic implants, and grafts. Academic and graduate students interested in producing a selective biological response at the surface of a given biomaterial will find the detailed coverage of interactions at the nanometre scale useful. Practitioners will also benefit from guidance on how to pre-screen many inappropriate designs of biomedical devices long before any expensive, animal or potentially risky clinical trials. Enhanced by the use of case studies, the book is divided in to four topical sections. The final section is dedicated to the application of related topics making the book unique in its pragmatic approach to combining high end interdisciplinary scientific knowledge with commercially viable new technologies. Contributing to the newly emerging discipline of 'nanomedicine', the book is written not only by experts from each relevant specialty but also by practitioners such as clinicians and device engineers from industry.Trade ReviewThe book originates from the activity of a BioElectricSurface consortium, funded by the European Commission under the FP-7 Nanosciences, Nanotechnologies, Materials and New Production Technologies (NMP) program and discusses the crucial role surface charge plays in the interaction between materials in biological and medical applications. The first part of the book covers new findings in biology, e.g. bone growth by charged hydroxyapatite and photocatalytic effect in doped titania and includes useful explanations of the many modern techniques used to create and measure electric charges at surfaces and intersurfaces. The first part of the book contains some very useful information, such as discussion of the polarization of hydroxyapatite, which increased bone growth on the negative surface while no growth was observed on the positive surface, and commentary on the increased photocatalytic activity of doped titania . This section also concisely, but thoroughly, analyses thermally stimulated depolarization current methods, the laser intensity modulation method of charge measurements, scanning probe, Kelvin probe force and electrostatic force microscopy, and the streaming potential measurement techniques used for wet cases. The techniques utilized for interfacial measurements, such as confocal laser scanning microscopy, are also covered in chapter 4. Part 2 describes many practical examples in which the surface interactions play an essential role. For example, chapter 5 discusses immobilized enzymes on porous surfaces in biocatalysts, drug delivery, and biosensors, while chapter 6 goes on to describe improvement of the extracellular matrix (ECM) by the interactions of host tissue cells with the implant surface Chapters 7, 8 and 9 discuss antibody immobilization on solid surfaces, adhesion, proliferation and differentiation of bone-forming cells with electrostatic charge at biomaterials surfaces and interactions of biofilm-forming bacteria with abiotic surfaces. Endothelial cells and smooth muscle cells on the biomaterials surfaces, interactions of bacteria and fungi on biofilms in hospital acquired infections and immunological response of electrostatic charge at the surface of biomaterials are covered in chapters 10, 11 and 12. Such elaborate discussions show the relevance of surface charge in biological interactions at and with non-biological surfaces and, I strongly believe, will provide a solid foundation for interested readers who are willing to bring innovative ideas of surface modifications to generate or control a specific biological response on implantable therapeutic devices. Part 3 of the book is a logical progression from parts 1 and 2, and describes some of the important applications where surface charge is believed to play a significant role. These include: Community and hospital acquired infections of methicillin-resistant staphylococcus aureus (MRSA), MRSA-resistant textiles, inhibition of encrustation in urological devices and the reduction of restenosis in cardiovascular stents. The book finishes with a general overview of a new class of materials, named as vector materials, where the interfaces between biomaterial and biological environment can be manipulated by the application of vectorial effects induced by electrical polarization. Surface charges are frequently experienced by the frictional electricity in textiles. The infection of bacteria and the restenosis of implanted stenosis are broadly concerned matters in the society. As a basic research, it is noteworthy that negatively charged hydroxyapatite induces new bone. The book shows that the study of electric charge in surfaces is important to understand the basic mechanism of all these matters. The many topics introduced in this book promises more rapid progress in future research. The abbreviation of technical words sometime hinders the understanding of sentences, but the subject index at the end of the book helps greatly to solve this difficulty. The arrangement of chapters is also well ordered. The Editor’s kind efforts are appreciated. -- Eiichi Fukada, Kobayasi Institute of Physical Research, Tokyo, Japan and Emeritus Scientist, RIKEN, Wako, JapanTable of ContentsElectrostatic Charge on Biomaterials Surface; Electrical modifications of biomaterials' surfaces: Beyond hydrophobicity and hydrophilicity; Photocatalytic effects in doped and undoped titania; Surface charge measurements on biomaterials in dry and wet conditions Measurements of surface and interfacial charge and morphology in electrically modified materials; Protein Interactions at the surface; Immobilisation of enzymes on porous surface; Fibrous proteins interactions with modified surfaces of biomaterials; Antibody immobilisation on solid surfaces: methods and applications; Cellular Interactions with Abiotic Surfaces; Interactions of bone forming cells with electrostatic charge at biomaterials surface; Interactions of biofilm-forming bacteria with abiotic surfaces; Endothelial cells and smooth muscle cells (SMC) interactions at biomaterials surfaces; Interactions of Bacteria and fungi at the surface; Immunological response of electrostatic charge at the surface of biomaterials; IV. Applications; Community and hospital acquired Staphylococcal infections; MRSA resistant textiles; Inhibition of urological devices; Encrustation; Reduction of restenosis in cardiovascular stents; Regulatory and safety issues related to biomedical devices
£115.89
Royal Society of Chemistry Fat Chemistry: The Science behind Obesity
Book SynopsisCurrently, the health of over half the adult population in the UK suffers because of fat. The UK is not alone: obesity is a global problem, but the populations of some countries are heavier than others. This book probes the chemistry of fat in our bodies, providing a unique insight into understanding obesity, and how this material becomes accumulated to cause obesity with particular emphasis on the contribution of nutrition beyond calories. It visits the current hot topic of the genetic origins of obesity and progresses through to the relatively under publicised field of epigenetics, emphasising its importance to understanding the current epidemic. Coming in the wake of the establishment of international collaborations, the book aims to quantify the extent of the contribution of nutritional deficiencies to body weight gain. Yet even before these studies begin some important links have been identified and the molecular mechanisms by which they induce obesity have been mapped. This information reveals a serious problem for the next generation, but it is expected to provide the necessary information to tackle the obesity epidemic. Based on an extensive review of scientific literature, this topical book is written in a way that is accessible to the non-specialist. Suitable for the general public, the principal focus of the book is to advance the public understanding and awareness of science through the high interest subject of obesity. However, many universities recommend public understanding of science texts to students as a means of broadening general knowledge and as a means to emphasise to students the importance of communicating their research to the public. This book will be instrumental in developing this knowledge.Table of ContentsIntroduction; General fat; In the beginning; Stone Age obesity; Hardwired obesity; A thrifty genotype or human nature?; Softwired obesity; Beyond the helix; What we need; Death in the pot; The chemistry of food; Nutritional medication; Hidden under a blanket of fat; Your choice; Index
£24.99
Royal Society of Chemistry Carbohydrate Chemistry and Biochemistry:
Book SynopsisThis fully updated and expanded second edition of a highly popular text book focuses on the structure and mechanism in carbohydrate chemistry and biochemistry. Carbohydrates play important roles in biological systems as energy sources, as structural materials, and as informational structures (when they are often attached to proteins or lipids). Their chemical reactivity and conformational behaviour is governed by mechanistic and stereochemical rules, which apply as much to enzymic as to non-enzymic reactivity. The same principles of reactivity and conformation govern changes brought about in the process industries, such as pulp, paper and food. Extensively referenced with citations and a detailed index, the book contains everything the reader needs to know to start a carbohydrate research project with one of the real strengths being the treatment and integration of the important physical-chemical principles and methods (though lead references only are given to the finer points of carbohydrate synthesis). The book is suitable for both researchers who are new to the subject and those more established as well as a readership from diverse backgrounds and interests, including chemists, biochemists, food scientists and technologists involved with the processing of polysaccharides in the paper, textile, cosmetics, biofuels and other industries.Trade Review"...the book provides an excellent and authoritative reference resource for beginning and established researchers interested in structural and mechanistic aspects of carbohydrate (biochemistry)""useful addition to the library of individuals with interests in theglycoscience field, as well as students wishing to learn moreabout this area.""the overall view of the text is favorable, since it covers so many varied topics, some perhaps unfamiliar to even the most seasoned glycoscientists""...this is an excellent treatment of carbohydrate chemistry. It belongs in libraries and on the bookshelves of carbohydrate chemists and biochemists.""..an invaluable companion and introduction to the primary literature of the field."Table of ContentsStructures of the open-chain forms of reducing sugars and related molecules. Mechanistic probes of sugar carbonyl group additions; Conformations of Sugar Rings and Glycosidic Linkages; Nucleophilic Substitution a the Anomeric Centre; Enzymic Glycoside Hydrolysis and Transglycosylation: Kinetics and Mechanism; Primary Structure and Conformation of Oligosaccharides and Polysaccharides; Heterolytic Reactions of OH Groups; Heterolytic Chemistry of the Carbon Chain; Glycosyl Transferases and Oligosaccharide and Polysaccharide Biosynthesis; Glycoconjugates: Biosynthesis and Properties; One-electron Chemistry of Carbohydrates; Appendix; Subject Index
£79.99
Royal Society of Chemistry Advances in Dermatological Sciences
Book SynopsisAdvances in Dermatological Sciences collates major scientific research achievements over the last two years in a diverse range of dermatological research fields. Examples of key topics covered include experimental models, toxicology, regulatory, exposure assessment, therapeutics, cosmetics and decontamination. A unique feature of the book is the introductory chapter to each section that is written by an internationally-recognised expert summarising work to date, and explaining how new research contributes to our overall understanding of the skin and where the next major developments are likely to be focussed in the future. Each section contains several experimental research chapters that present contemporary research on 'hot topics' or major advances relevant to the dermatological sciences. The book incorporates a broad range of specialist topics rather than focussing on one single aspect so as to appeal to a broader audience. Thus, the proposed book will distil cutting-edge advances across all of the dermatological sciences into one major work and so provide a one-stop portal for accessing the current state of knowledge that will communicate both a readily accessible overview (in the form of introductory chapters) and also detailed, expert contributions. The text will be essential reading for interdisciplinary scientists working in dermal pharmacology, dermatological and dermatotoxicological sciences.Table of ContentsCutaneous Biology; Experimental and Mathematical Models; Dermal Therapeutics; Cosmeceuticals; Skin Protection and Decontamination; Regulatory and Toxicology; Subject Index
£166.25
Royal Society of Chemistry Comprehensive Biomarker Discovery and Validation
Book SynopsisComprehensive Biomarker Discovery and Validation for Clinical Application provides the reader with an extensive introduction into all aspects of proteomics biomarker discovery, validation and development. It discusses the current status of science and technology, its limitations, bottlenecks as well as future development trends to improve the success rate of translating biomarker discovery into useful clinical tests. The most important feature of the book is to provide an overview of current technologies and the challenges encountered during biomarker discovery and validation, such as patient selection, sample handling, data processing, statistical analysis and registration and approval of validated biomarkers through European and US regulatory authorities. The authors introduce the reader to each of these topics in significant detail and provide examples or guidelines for best practice. There are prominent chapters included on biomarkers in translational and personalised medicine; an introduction to regulatory affairs and bring biomarkers to the market; biomarker discovery and the use of mass spectrometry based profiling platforms; MALDI imaging techniques in tissue-based biomarkers discovery and a clinical application study on the use of diagnostic assays for early diagnosis of heart failure using various proteomic methods. The book concludes with a final chapter on future trends in biomarker discovery and validation. The book targets a readership of industrial and academic researchers that are involved in biomarker discovery and validation or that manage biobanks, develop sample preparation methods, analytical profiling systems and bioinformatics tools. Common pitfalls and success stories in biomarker discovery are highlighted and guidelines for best practice are provided for the different parts of the procedure. The book will be an essential information resource for scientists working in the field.Table of ContentsIntroduction to biomarker discovery and validation; Clinical context of proteomics biomarker discovery and validation, authority regulations; Biomarker discovery: Patient selection; Biomarker discovery: Experimental design and biobanking; Biomarker discovery: body fluids; Biomarker discovery: tissues; Biomarker discovery: mass spectrometry based profiling platforms; Biomarker discovery: array based profiling platforms; Biomarker discovery: data preprocessing for LC-MS data; Biomarker discovery: data preprocessing for Maldi imaging, and 2D electrophoresis and protein arrays data; Biomarker discovery: statistical analysis and validation; Biomarker validation: biomarker validation methods; Functional biomarker validation; Clinical application: case studies Clinical application: summary and future technology development trends
£151.99
Royal Society of Chemistry Biotherapeutics: Recent Developments using
Book SynopsisThis book illustrates the successful partnership of chemistry and biology to advance successful biotherapeutic modalities. Molecular design to create function is common to both chemical and molecular biology, and this text highlights recent developments from these disciplines that have delivered drugs, clinical candidates or significantly advanced biotherapeutic approaches. Biotherapeutics are often considered to be beyond the reach of the medicinal chemist, but this book demonstrates that chemistry has an essential role in the future success of this area, by explaining and describing the chemical biology technologies that underpin specific therapeutic advances and demonstrating the unique value of molecular design and understanding. Covering topics such as selective protein modification, immunopharmacotherapy, chemically programmed vaccinations, nanobodies and antibodies, this book provides essential reading for medicinal and pharmaceutical chemists working in both industry and academia.Table of ContentsSynthetic Vaccines; Peptide Epitope Expressions; Carbohydrate vaccines; MicroRNA; Recent Advances in Antibody-Directed Conjugates; Selective Protein Modifications; Immunopharmacotherapy; Technologies being applied to B cell repertoire screening for Antibodies against Infectious Pathogens; Cyclotides and Cysteine-Knot Peptides; Phage Expression of Chemically-Constrained Cyclic Peptides; Nanobodies
£151.99
Royal Society of Chemistry Emerging Drugs and Targets for Parkinson's
Book SynopsisAffecting over 1.5 million people across the world, Parkinson's disease is a progressive neurological condition characterized, in part, by the loss of dopaminergic neurons in the substantia nigra pars compacta. It affects 1.5% of the global population over 65 years of age. As life expectancy is increasing, over the next few years the number of patients with Parkinson´s disease will grow exponentially. To date, there are no available treatments that are capable of curing Parkinson´s disease, and the current goal of therapy, dopamine replacement strategies, is to reduce symptoms. After several years of disease progression, treatment is complicated by the onset of motor fluctuations and dyskinesias. This information reveals the great importance and social need of finding an effective therapeutic intervention for Parkinson´s disease. This exemplary new book reviews some of the most outstanding examples of new drugs currently in pharmaceutical development or new targets currently undergoing the validation process to try to reach the Parkinson´s drug market in the next few years as potential disease modifying drugs. Providing up to date and comprehensive coverage, this book is essential reading for researchers working in academia and industry in any aspect of medicinal chemistry or drug discovery.Trade Review"The introductory chapters describingn the current state of knowledge on pathogenesis, pathophysiology, symptoms, unmet medical needs, and new therapeutic targets are excellent." "The following new approaches are covered in some detail: protein phosphatases, a-synuclein, glutamate receptor subtypes, LRRK2 kinase, phosphodiesterases, serotonin 5-HT1A receptor, tryptophan metabolism, P2X7 purine (ATP) receptor, carotid body transplantation, and stem-cell therapy. This appears to present a subjective selection of potentially important targets for future AD therapeutics." "Altogether, I can recommend this volume of the excellent RSC Drug Discovery Series to medicinal chemists, (chemical) biologists and pharmacologists interested in drug development for Parkinson’s disease." -- Prof. Christa E. Muller * Chemmedchem *Table of ContentsOverview on Parkinson disease. Rational for pharmacological intervention; Dopaminergic pathway and L-Dopa treatments. Future challenges; COMT Inhibitors: present problems and relevance of the new ones; MAO inhibitors for PD (Safinamide); Dopamine agonist: present and future (Pardoprunox); Therapies for dopaminergic-induced dyskinesias in Parkinson disease. (Fipamizole); Beyond the dopamine receptor: regulation of protein phosphatases; Molecular chaperones as rational drug targets for Parkinson's disease therapeutics; Alpha-synuclein assembly as a therapeutic target of PD; Alpha-synuclein (alpha-syn) phosphorylating polo-like kinase 2 (PLK2) as target for PD; Hsp70 molecular chaperones and Parkinson's disease; Glutamate receptors as therapeutic targets for Parkinson's disease; Targeting adenosine A2A receptors in Parkinson's disease; Leucine-rich repeat kinase-2 as target for Parkinson's disease; Phosphodiesterase inhibitors for PD treatment; P2X7 purinergic receptor: role in neurological disorders; Therapeutic role of 5-HT1A receptors in the treatment of schizophrenia and Parkinson's disease; D3 dopamine receptor agonists: neuroprotection in Parkinson's disease; Antioxidants and PD; Tryptophan metabolism in Parkinson's disease; Grafted neural stem cell-derived dopaminergic neurons for PD Therapy; Gene therapy for Parkinson's disease; Carotid body autotransplantation in Parkinson disease;Neurotrophic factor therapy for Parkinson's disease
£151.99
Royal Society of Chemistry Self-Assembly of Biopolymers: Faraday Discussion
Book SynopsisSelf-Assembly of Biopolymers University of Bristol, United Kingdom 16-18 September 2013 FARADAY DISCUSSIONS Volume 166, 2013 Farady Discussion 166 This volume focuses on the physical chemistry of novel self-assembling bio-conjugate or bio-hybrid materials. Soft matter has emerged as a coherent subject within the last ten years, and is of increasing relevance to interdisciplinary research at the interface of physical chemistry, physics, materials science and biology. Recently several exciting new directions have been pursued in this area, including developments in understanding amyloid fibrillization, liposome and polymersome self-assembly, DNA superstructure formation, biopolymer hydrogel self-assembly and how to control this to develop tissue scaffolds, and the control of biopolymer self-assemblies for applications in biomedicine. This volume focuses on the self-assembly of novel bio-hybrid materials, especially conjugates of proteins with polymers, glycosylation of proteins, polymer/virus hybrids etc.. Much work in this field has been driven by recent advances in synthetic methodology which has enabled exciting work on the production of self-assembling and self-organizing systems. These systems are under intense research for applications in tissue scaffolding, drug delivery systems. An understanding of the physical chemistry of self-assembly is essential for such applications. Topics covered in this volume include: • DNA condensation using polyelectrolytes • Self-assembly of polymer/protein and polymer virus conjugates • Self-assembly of lipids and polymerosomes • Self-assembly of carbohydrate/gluco polymer hybrid materials
£156.75
Royal Society of Chemistry Ion Specific Hofmeister Effects: Faraday
Book SynopsisThe hydration of ions and the interactions of ions with (bio)molecules play a key role in many natural and technological processes. These effects are usually framed in terms of the lyotropic or Hofmeister series which traditionally orders cations and anions according to their ability to salt-out proteins. Since its formulation more than one hundred years ago, the lyotropic series has been invoked in myriad effects including the crystallization of proteins, enzyme activities, the swelling of tissues, salt solubilities, ion exchange, surface tension of electrolytes, and bubble coalescence. Although it is now clear that the Hofmeister series is intimately connected with ion hydration in homogeneous and heterogeneous environments and with ion pairing, the molecular origin of these effects has been poorly understood. Biochemists and physical chemists have been typically using the term Hofmeister series to put a label on ion specific behaviour in various environments, rather than to reach a molecular level understanding and, consequently, an ability to predict a particular effect of a specific salt ion. This meeting (which took place at Queen's College Oxford in September 2012) aimed to respond to the emerging situation in which science has matured enough to be able to provide answers about the molecular nature of ion specific effects. It explored the most important issues in understanding the chemistry and biological effects of ions, with state of the art work being presented using advanced experimental and computational methods. Investigation of ion specific effects is truly interdisciplinary since it requires chemists, biochemists, and biophysicists to collaborate with each other, combining experimental and computational approaches. We invited researchers in these fields to take part in the Discussion and join the chosen speakers who are among the key scientists behind the recent renaissance of interest in ion specific effects. Themes covered included: Solvation of ions in the aqueous bulk and at interfaces Ion-ion interactions in water Interactions between ions and biomolecules (proteins, nucleic acids, membranes, etc.) in water. Specific Hofmeister effects of ions and osmolytes on protein association, precipitation, folding/unfolding, and activity
£156.75
Royal Society of Chemistry Lipids and Membrane Biophysics: Faraday
Book SynopsisOne of the key challenges in biophysics and chemical biology is gaining an understanding of the underlying physico-chemical basis of the highly complex structure and properties of biomembranes. It used to be thought that the lipid component played a mainly passive role, simply acting as a self-assembled bilayer matrix within which the active protein components functioned. However, it has now become clear that there is a intimate two-way interplay between the lipid and the protein components in determining membrane structure, organization and dynamics, and that lipids play many active roles in biological function. Concepts such as lateral segregation and domain formation, lateral pressure, curvature and curvature elasticity have attracted enormous interest in recent years, although their validity when applied to real biomembranes remains unclear or even obscure. This Faraday Discussion considered recent developments in the study of biomembrane structure, ordering and dynamics, with particular emphasis on the roles of lipids in these phenomena. As well as discussing new experimental and theoretical findings and novel methodologies, the meeting focused on exploring the relevance of concepts from amphiphile self-assembly and soft matter physics to understanding biomembranes.Table of ContentsPreface;Introductory Lecture: Basic quantities in model biomembranes;PAPERS AND DISCUSSIONS; Switchable domain partitioning and diffusion of DNA origami rods on membranes; The effect of cholesterol on the intrinsic rate of lipid flip–flop as measured by sum-frequency vibrational spectroscopy; Computer simulations of the phase separation in model membranes; STED microscopy detects and quantifies liquid phase separation in lipid membranes using a new far-red emitting fluorescent phosphoglycerolipid analogue; Critical point fluctuations in supported lipid membranes; General discussion; Lipid phase behaviour under steady state conditions; Transient pearling and vesiculation of membrane tubes under osmotic gradients; Mode specific elastic constants for the gel, liquid-ordered, and liquid-disordered phases of DPPC/DOPC/cholesterol model lipid bilayers; Tuning the aggregation behaviour of single-chain bolaphospholipids in aqueous suspension: from nanoparticles to nanofibres to lamellar phases; Polycontinuous geometries for inverse lipid phases with more than two aqueous network domains; Physical properties of mixed bilayers containing lamellar and nonlamellar lipids: insights from coarse-grain molecular dynamics simulations; General discussion; Spontaneous tubulation of membranes and vesicles reveals membrane tension generated by spontaneous curvature; Formation and analysis of topographical domains between lipid membranes tethered by DNA hybrids of different lengths; Molecular view on protein sorting into liquid-ordered membrane domains mediated by gangliosides and lipid anchors; Gaussian curvature elasticity determined from global shape transformations and local stress distributions: a comparative study using the MARTINI model; Elastic properties of polyunsaturated phosphatidylethanolamines influence rhodopsin function; Anomalous and normal diffusion of proteins and lipids in crowded lipid membranes; General discussion; Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation; Cell cycle dependent changes in membrane stored curvature elastic energy: evidence from lipidomic studies; Impact of oxidized phospholipids on the structural and dynamic organization of phospholipid membranes: a combined DSC and solid state NMR study; Materials characterization of the low temperature sensitive liposome (LTSL): effects of the lipid composition (lysolipid and DSPE–PEG2000) on the thermal transition and release of doxorubicin; Segregated ordered lipid phases and protein-promoted membrane cohesivity are required for pulmonary surfactant films to stabilize and protect the respiratory surface; Gibbs energy determinants of lipoprotein insertion into lipid membranes: the case study of Ras proteins; General discussion; Concluding remarks;
£156.75
Royal Society of Chemistry 2-Oxoglutarate-Dependent Oxygenases
Book SynopsisSince the discovery of the first examples of 2-oxoglutarate-dependent oxygenase-catalysed reactions in the 1960s, a remarkably broad diversity of alternate reactions and substrates has been revealed, and extensive advances have been achieved in our understanding of the structures and catalytic mechanisms. These enzymes are important agrochemical targets and are being pursued as therapeutic targets for a wide range of diseases including cancer and anemia. This book provides a central source of information that summarizes the key features of the essential group of 2-oxoglutarate-dependent dioxygenases and related enzymes. Given the numerous recent advances and biomedical interest in the field, this book aims to unite the latest research for those already working in the field as well as to provide an introduction for those newly approaching the topic, and for those interested in translating the basic science into medicinal and agricultural benefits. The book begins with four broad chapters that highlight critical aspects, including an overview of possible catalytic reactions, structures and mechanisms. The following seventeen chapters focus on carefully selected topics, each written by leading experts in the area. Readers will find explanations of rapidly evolving research, from the chemistry of isopenicillin N synthase to the oxidation mechanism of 5-methylcytosine in DNA by ten-eleven-translocase oxygenases.Table of ContentsBiochemical Diversity of 2-Oxoglutarate Dependent Oxygenases; Introduction to Structural Studies on 2-Oxoglutarate Dependent Oxygenases and Related Enzymes; Mechanisms of 2-Oxoglutarate-Dependent Oxygenases; Synthetic Models of 2-Oxoglutarate-Dependent Oxygenases; Collagen Hydroxylases; The Role of 2-Oxoglutarate-Dependent Oxygenases in Hypoxia Sensing; JmjC Lysine Demethylases; AlkB and its Homologues—DNA Repair and Beyond; RNA Demethylation by FTO and ALKBH5; Role of ALKBH8 in the Synthesis of Wobble Uridine Modifications in tRNA; The TET/JBP Family of Nucleic Acid Base-Modifying 2-Oxoglutarate and Iron-Dependent Dioxygenases; 2-Oxoglutarate-Dependent Hydroxylases Involved in DNA Base J (β-D-glucopyranosyloxymethyluracil) Synthesis; Dioxygenases of Carnitine Biosynthesis: 6-N-Trimethyllysine and γ-Butyrobetaine Hydroxylases; Phytanoyl-CoA Hydroxylase: a 2-Oxoglutarate Dependent Dioxygenase Crucial for Fatty Acid Alpha-Oxidation in Humans; Role of 2-Oxoglutarate Dependent Oxygenases in Flavonoid Metabolism; Gibberellin Metabolism; 2-Oxoglutarate Dependent Oxygenases of Cephalosporin Synthesis; Recent Advances in the Structural and Mechanistic Biology of Non-Heme Fe(II), 2-Oxoglutarate, and O2 Dependent Halogenases; Isopenicillin N Synthase; 1-Aminocyclopropane-1-Carboxylic Acid Oxidase; 4-Hydroxyphenylpyruvate Dioxygenase and Hydroxymandelate Synthase: 2-Oxo Acid-Dependent Oxygenases of Importance to Agriculture and Medicine
£170.05
Royal Society of Chemistry Histological Techniques: An Introduction for
Book SynopsisHistological techniques form the basis of many areas of research, yet they can often be poorly understood. Aimed at postgraduate students and those at an early stage of their career, this title provides a detailed and comprehensive introduction to histological techniques. With detailed images and slides, this book provides a unique overview of the area while providing the reader with a guide to how to use and incorporate histological techniques within their own research. Written by experts working within the field, this book is an essential handbook for anyone wanting to learn more about histological methods and how to apply them successfully.Trade Review"Chapters 5, 6, and 7 constitute the core of the book and the most useful information for the target audience as well as for other professionals who are interested in understanding how tissue preparation occurs in a regular basis." "some helpful hints to toxicologists, particularly in their formative years on how histology works. As such it is a valuable resource." "The section on Introduction to Histopathology covers much ground in a succinct fashion and should be very useful to the audience in mind. It is factual and well organized. The section on the microscope is extensive and well written and should be useful to beginning pathologists as well as toxicologists and would be a good reference section to all interested in this field." "In summary, this book is a valuable resource for training toxicologists, pathologists, and technicians, and it will be a good addition to one’s reference library." -- Richard Ochoa * International Journal of Toxicology, 2015, Vol. 34(2) 211-214 *The opening sentence of the preface identifies the target audience and broad aim of this book – "This little book is for toxicologists who are in the early stages of their careers and want to know something about histological techniques". It is not, and does not pretend to be, a standard textbook on histological techniques, for which the reader should head straight for a definitive tome such as Bancroft’s Theory and Practice of Histological Techniques (now in its 7th edition). It does however offer something that is not easily distilled from the authoritative text books – in plain and accessible language the authors give us a lucid explanation of the hows and whys of histological techniques, supported throughout by real life examples and personal insights. The emphasis is very much on what may be considered "traditional" histology – those interested in in-situ hybridisation, laser capture microscopy, gene sequencing and the like will need to look elsewhere. Note also that electron microscopy, slide scanning and quantification are also out of scope of this work. A total of 9 chapters, the first one an introduction to the scope and aims of the book, cover 8 discrete areas – each chapter serving as a worthy introduction to its chosen subject matter. The chapter covering histopathology explains the key physiological and disease process as seen through the light microscope, with some complex concepts eloquently explained in easily digestible layman’s language. The chapter on light microscopes tells you everything you are ever likely to need to know on the subject matter, there is a useful and simple guide to how to actually use the microscope optimally – something many experienced microscopists tend to have forgotten – though, running to nearly 50 pages, there is perhaps too much detail in this section. Next up is "how to examine histological sections". For the most part this is a real gem, full of handy tips garnered over years of experience; I have not seen this theme covered as well as this elsewhere. A couple of chapters take us through the technical aspects of sample preparation from fixation of the specimen through to the unstained section on the slide; the authors’ vast experience permeates throughout. The text is peppered with little tips garnered from first-hand experience and there are explanations of the theories behind the methods used. The closing 3 chapters on staining techniques are perhaps the weakest part of the work – the theory of staining is explained informatively and, whilst enlightening within the scope covered, only a relatively small selection of "standard staining techniques" are included – for instance there are no techniques discussed for amyloid, mineralisation, organisms or CNS, though the extensive bibliography does point you in the right direction for these. The section on histochemistry (including immunohistochemistry) is a little too concise; there is no room for important topics such as antibody validation and automated staining platforms. The text covering the ubiquitous H&E stain is a real treasure though– even the most seasoned microscopist should learn something new by reading this. The refreshing writing style makes each section a nice easy read; the authors clearly know their subject matter. There is even a subtle humour to the writing at times – I particularly enjoyed the "karyorrhectic cell masquerading as a snowman" (check out the picture on page 35) and recognising the novice stainer by "the rainbow appearance of their hands". There are occasional digressions into areas of purely historical interest – in this day and age do we still need to know about the Cambridge rocking microtome and do any pathologists really still do hand drawings of what they observe down the microscope? But on the whole the book is highly instructive and full of insight. So, does the book meet its aims? In general I think it does – for the toxicologist early in their careers, especially those who perform some of their own lab work, this is a highly readable introductory text, though bear in mind that it deals largely with traditional methods. In fact there are a lot of useful nuggets in here for laboratory scientists and trainee pathologists, for whom it would make an excellent companion volume to one of the heavyweight standard texts. -- Barry Reed, GlaxoSmithKline RandD * BTS News vol 1:3 *Table of ContentsIntroduction; An Introduction to Histopathology; The Light Microscope; How to Examine Histological Sections; Tissue Processing; Embedding Media and Sectioning; Attaching Sections to Slides and Mounting; Standard Staining Techniques; The Theory of Histological Staining
£80.74
Imperial College Press Protein Bioseparation Using Ultrafiltration:
Book SynopsisUltrafiltration is a pressure-driven, membrane-based separation process, which is used for a broad variety of applications, ranging from the processing of biological macromolecules to wastewater treatment. It has significant advantages over competing separation technologies. Food and biotechnological applications account for nearly 40% of the current total usage of ultrafiltration membranes. Protein bioseparation is an important component of this application segment. Ultrafiltration is used for protein concentration, desalting, clarification and fractionation (i.e. protein-protein separation). Concentration, desalting and clarification are technologically less demanding and have been in used in the bioprocess industry for some time. Protein fractionation, on the other hand, is a challenging proposition and is definitely a more recent development. This book focuses primarily on protein fractionation.Table of ContentsMembranes; Membrane Module and Operation; Permeate Flux in Ultrafiltration; Protein Transmission Through UF Membranes; Selectivity of Solute Separation in UF; Protein Concentration; Diafiltration of Protein Solutions; Protein Fractionation Using Ultrafiltration; New Developments.
£72.20
Imperial College Press Ccn Proteins: A New Family Of Cell Growth And
Book SynopsisThe CCN Proteins are thought to play key roles in the biology of normal cell, tissue, organ, and body, and altered expression of CCN proteins is associated with several pathologies, including fibrosis and cancer. Because of its importance, the CCN field is expanding at a fast pace. Research articles in this field have recently increased logarithmically, and a book that is up-to-date, comprehensive, authoritative and affords insights into the biological roles of CCN proteins, is timely.CCN Protein: A New Family of Cell Growth and Differentiation Regulators presents the most recent progress in the field of CCN proteins, a new family of secretory signaling molecules that are involved in several fundamental biological progress. These proteins share a unique multimodular organization and present a partial identity with four families of regulatory proteins controling growth and development. The book covers the roles of CCN proteins in the control of cell proliferation and differentiation during normal development, wound repair, chondrogenesis and bone development, angiogenesis, tissue regeneration, fibrosis, renal diseases and cancer development.Table of Contents* The CCN Family of Proteins: An Overview (B Perbal & M Takigawa) * Roles of CCN2/CTGF in the Control of Growth and Regeneration (M Takigawa et al.) * Integrin-Mediated CCN Functions (L F Lau & S C-T Lam) * Expression and Roles of CCN2 During Odontogenesis (M Kanyama et al.) * CCN Genes and the Kidney (B L Riser et al.) * CCN Proteins in Liver Injury and Disease (A W Rachfal & D R Brigstock) * Genetic Analysis of CCN Gene Function in Mammalian Development (L M Dornbach & K M Lyons) * CCN Family in Embryonic Development (Non-Mammalian Models) (B V Latinkic) * CCN3 Expression and its Role During Development (K-I Katsube) * Regulation of CCN Proteins by Alternations of the Cytoskeleton (B Chaqour & M Goppelt-Struebe) * Pathogenesis of Systemic Sclerosis and CCN2 (Connective Tissue Growth Factor) (K Takehara) * Function and Regulation of CCN5 (M R Gray & J J Castellot Jr) * CCN3: A Multifunctional Signaling Regulator (N Planque et al.) * CCN Proteins and Connexins: Interactions and Growth Control (C Fu et al.) * The Role of CCN1 in Tumorigenesis and Cancer Progression (J O'Kelly & H P Koeffler) * CCN4 and CCN6 Variants Wnt-Inducible Signaling Pathway (S Tanaka)
£137.75
Imperial College Press Non-covalent Interactions In Proteins
Book SynopsisAlthough textbooks on the physics of condensed matter consider non-covalent interactions in detail, their application for analysis of protein properties is often poorly presented or omitted. On the other hand, books on biochemistry, molecular modeling or molecular simulation introduce these interactions in the context of the corresponding topic, which sometimes results in superficial explanations of their nature. This book succeeds in uniting comprehensive considerations of non-covalent interactions with the specificity of their application in protein sciences.The ideal aid for students of physics or chemistry, with interests in biology and biophysics, the book can also be useful for students of biology, biochemistry, or biomedicine who want to extend their knowledge of how protein properties are described at the molecular level.Table of ContentsOverview of Protein Structural Elements and Basic Definitions; Non-covalent Interactions and Structure-Function Relationships in Proteins; Observation of van der Waals Interactions; Nature of van der Waals Interactions; Potential Functions for Application in Proteins; Approximation for Polyatomic Systems; Nature of Hydrogen Bonds; Geometry and Strength of the Hydrogen Bond; Hydrogen Bonds in Proteins; Hydrogen Bonds and Protein Stability; Nature of Hydrophobic Interactions, Pseudo Forces; Water; Hydrophobic Effect; Hydrophobic Interactions in Proteins; Debye-Huckel Theory; Ion-Solvent Interactions; Calculation of Electrostatic Interactions in Proteins; Why Does One Need to Know Ionization Equilibria?; Factors Determining Ionization Equilibria in Proteins; Combinatorial Problem; Cooperative Ionization; Allocation Variation of Polar Hydrogen Atoms; Examples for pH-Dependent Hydrogen Bonding; Conformational Flexibility Involving Non-Hydrogen Atoms; Unfolding Induced by pH; Modeling of Unfolded Proteins; Thermal Stability of Proteins.
£117.80
Imperial College Press Molecules Of Death (2nd Edition)
Book SynopsisThis book has been developed over many years from several popular courses taught to students at both Birmingham and London universities. It provides an important step in introducing principles and concepts within the field of toxicology. The underlying mechanisms of toxicity are highlighted through examples taken from gases, minerals, plants, fungi, bacteria, marine creatures, industrial chemicals and pharmacological agents.In this second edition, the text has been completely revised and expanded with the addition of six new chapters — carbon monoxide, hydrofluoric acid, lead, mushroom, toxins, paracetamol, paraquat and diquat. Each chapter is self-sufficient, enabling readers to dip into chapters of interest at random without any lack of understanding. The book is informative, with numerous clinical details, and will appeal to those who wish to delve into this fascinating subject.Table of ContentsAflatoxin (J C Ritchie); Botulinus Toxin (M E Smith); Carbon Monoxide -- The Silent Killer (L J Wilkinson); Domoic Acid (R A R Tasker); Ecstasy (R A Braithwaite); Heroin (R A Braithwaite); Hydrofluoric Acid (S C Mitchell); Hydrogen Sulphide (G B Steventon); Lead: An Old and Modern Poison (D B Ramsden & T Pawade); Mercury (S Aldred & R H Waring); Mushroom Toxins (R H Waring); Nerve Gases (J Burdon); Nicotine and the Tobacco Alkaloids (J W Gorrod & M-C Tsai); Paracetamol (Acetaminophen) (G Steventon & A Hutt); Paraquat and Diquat (R M Harris); Phosphorus (S C Mitchell); Radon (J Woodhouse); Ricin (M J Ruse); Snake Toxins (I C Shaw); Spider Toxins (R H Waring); Strychnine (R M Harris); Tetrodotoxin (M Wheatley); Thallium (D B Ramsden).
£110.70
Imperial College Press Molecules Of Death (2nd Edition)
Book SynopsisThis book has been developed over many years from several popular courses taught to students at both Birmingham and London universities. It provides an important step in introducing principles and concepts within the field of toxicology. The underlying mechanisms of toxicity are highlighted through examples taken from gases, minerals, plants, fungi, bacteria, marine creatures, industrial chemicals and pharmacological agents.In this second edition, the text has been completely revised and expanded with the addition of six new chapters — carbon monoxide, hydrofluoric acid, lead, mushroom, toxins, paracetamol, paraquat and diquat. Each chapter is self-sufficient, enabling readers to dip into chapters of interest at random without any lack of understanding. The book is informative, with numerous clinical details, and will appeal to those who wish to delve into this fascinating subject.Table of ContentsAflatoxin (J C Ritchie); Botulinus Toxin (M E Smith); Carbon Monoxide -- The Silent Killer (L J Wilkinson); Domoic Acid (R A R Tasker); Ecstasy (R A Braithwaite); Heroin (R A Braithwaite); Hydrofluoric Acid (S C Mitchell); Hydrogen Sulphide (G B Steventon); Lead: An Old and Modern Poison (D B Ramsden & T Pawade); Mercury (S Aldred & R H Waring); Mushroom Toxins (R H Waring); Nerve Gases (J Burdon); Nicotine and the Tobacco Alkaloids (J W Gorrod & M-C Tsai); Paracetamol (Acetaminophen) (G Steventon & A Hutt); Paraquat and Diquat (R M Harris); Phosphorus (S C Mitchell); Radon (J Woodhouse); Ricin (M J Ruse); Snake Toxins (I C Shaw); Spider Toxins (R H Waring); Strychnine (R M Harris); Tetrodotoxin (M Wheatley); Thallium (D B Ramsden).
£80.75
University Science Books,U.S. DNA Replication, second edition
Book SynopsisOften imitated but never rivalled, DNA Replication, Second Edition, regarded around the world as a classic of modern science, is now back in print in a paperback edition. Kornberg and Baker's insightful coverage of DNA replication and related cellular processes have made this 1992 edition the standard reference in the field.Trade Review'It is an excellent reference book on DNA and nucleic-acid enzymes, and every molecular biology laboratory should have a copy for easy access to the principles underlying today's DNA technology...The book is an excellent resource for graduate teaching and should also be a useful source of background material for undergraduate courses in biochemistry.' - NatureTable of Contents1: DNA Structure and Function 2: Biosynthesis of DNA Precursors 3: DNA Synthesis 4: DNA Polymerase I of E. coli 5: Prokaryotic DNA Polymerases Other Than E. coli Pol I 6: Eukaryotic DNA Polymerase 7: RNA Polymerases 8: Primases, Primosomes, and Priming 9: Ligases and Polynucleotide Kinases 10: DNA-Binding Proteins 11: DNA Helicases 12: Topoisomerases 13: Deoxyribonucleases 14: Inhibitors of Replication 15: Replication Mechanisms and Operations 16: Genome Origins 17: Bacterial DNA Viruses 18: Plasmids and Organelles 19: Animal DNA Viruses and Retroviruses 20: Regulation of Chromosomal Replication and Cell Division 21: Repair, Recombination, Transformation, Restriction, and Modification 22: Synthesis of Genes and Chromosomes
£80.75
TFM Publishing Ltd Evidence-based Management of Lipid Disorders
Book SynopsisPractising evidence-based medicine necessarily depends on the clinician having access to the best evidence available, but in a fast-moving field, keeping up to date with the latest developments is a challenging prospect. In this new volume, leading experts focus on the most important clinical issues associated with the management of Lipid Disorders, evaluating and interpreting the evidence available to provide the reader with a reliable summary of our current knowledge. Topics covered include therapeutic strategies for managing hereditary lipid disorders, including familial hypercholesterolaemia, both in adults and children, and familial combined hypercholesterolaemia. The authors also evaluate the evidence for a link between inflammatory disease and cardiovascular risk; the metabolic syndrome and the interconnections between dyslipidaemias and diabetes. They also look at therapeutic challenges such as the management of patients who are statin resistant, and the control of lipid levels in those suffering renal insufficiency. Tables highlight important data, evidence from trial results and expert reports, and each section concludes with a series of Key Points that present a summary of evidence-based recommendations for best practice, graded according to the quality of that evidence. The book provides the busy clinician with a unique analysis of the data supporting current therapies and will help the reader formulate effective strategies for treating their own patients.Table of ContentsLipoprotein metabolism: what do we know now?; The epidemiological aspects of lipid and lipoprotein levels in relation to cardiovascular diseases; Are lifestyle modifications a successful means for controlling lipid levels in the long run?; What are the diagnostic and therapeutic strategies for hereditary hypo-and hypercholesterolaemia?; Does raising HDL protect against atherosclerosis?; How do we diagnose hypertriglyceridaemia in clinical practice and what are the consequences for treatment?; What is the optimal treatment of familial combined hypercholesterolaemia?; How should we manage lipid and lipoprotein disorders in children?; What is the role of dyslipidaemia in the metabolic syndrome and diabetes mellitus?; What are the consequences of renal insufficiency or the nephrotic syndrome for lipid levels?; Is there a link between chronic inflammatory diseases and cardiovascular risk?; What is the evidence for a physiological and pathogenic role of lipoprotein (a)?; How do we identify and treat sitosterolaemia?; How can we deal with inborn errors in cholesterol and bile acid biosynthesis?; Differential diagnosis of patients with tendon xanthomas; When should we fear for statin interactions?; What are the considerations in patients who are statin resistant?
£42.50
Scion Publishing Ltd Glycobiology
Book SynopsisThis glycobiology book is truly unique. Produced to commemorate the 80th birthday of Nathan Sharon, Glycobiology is an essential reference tool for anyone working in the field. Most research review volumes are narrowly focused. This book is different. It is a state-of-the-art fully comprehensive review volume covering a deliberately wide spectrum of work in this important field. With 28 chapters, covering over 350 pages, this title describes the latest research findings - from chemistry to biology and from pure science to industrial and medical applications. The book is written by world-class researchers and brings the reader fully up-to-date with the latest advances and forward thinking. All the major areas of glycobiology are covered including the synthesis of carbohydrates and glycoconjugates, their structural and functional analysis, carbohydrate binding proteins, carbohydrate modifying enzymes, and the applications of glycobiology research in medicine and industry. All active researchers in the glycosciences will value access to this important research compendium whether it be in the local library or in the lab.Table of ContentsSECTION 1. Introduction 1. Half a century at the carbohydrate-protein interface Clare Sansom, Birkbeck College 2. Glycobiology - discovery, diagnostics and drugs Raymond Dwek et al., University of Oxford SECTION 2. Synthesis of Carbohydrate and Glycoconjugates 3. Sugar-lectin interactions: glycotargeting with synthetic glycoconjugates Michel Monsigny et al., CNRS Orléans 4. Recent developments in the synthesis and application of sialylmimetics Hansjörg Streicher and Heike Busse, University of Sussex SECTION 3. Analysis and Structure 5. Structure and function of the chondroitin/dermatan sulfates Robert Lauder, Lancaster University 6. Revealing the hidden dimensions of glycosaminoglycans in solution and protein complexes with saccharide libraries, FTIR, and SRCD David Fernig et al., University of Liverpool 7. Structural determination of N-linked glycans by matrix-assisted laser desorption/ionization and electrospray ionization mass spectrometry David Harvey, University of Oxford 8. Integrated approach to glycan structure–function relationships Ram Sasisekharan, MIT SECTION 4. Cell Biology of Carbohydrates and Glycoproteins 9. Some observations on the biology of cell surface heparan sulfate proteoglycans John Gallagher, Christie Hospital Manchester 10. Galectins: effective modulators of cytoskeletal organization and cellular growth — focus on galectin–8 as a model system Yehiel Zick, Weizmann Institute of Science 11. Intracellular lectin involvement in glycoprotein maturation and quality control in the secretory pathway Gerardo Lederkremer, Tel Aviv University SECTION 5. Carbohydrate-Binding Proteins 12. The diversity of sialic acids and their interplay with lectins Roland Schauer, Biochemisches Institut Kiel 13. Structure and carbohydrate specificity of β-prism I fold lectins M. Vijayan, V. Surolia and K. Sekar, Indian Institute of Science 14. Protein–glycan interactions in immunoregulation: galectins as tuners of the inflammatory response Gabriel Rabinovich, University of Buenos Aires 15. Recognition of bacterial glycoepitopes by pulmonary C-type lectins as an arm of lung innate immunity Itzhak Ofek, Tel Aviv University 16. Selectin and integrin recognition of ligands under shear flow: affinity and beyond Ronen Alon, Weizmann Institute of Science SECTION 6. Carbohydrate-Modifying Enzymes 17. Complex carbohydrate-modifying enzymes Spencer Williams, University of Melbourne 18. Glycosyltransferases specific for the synthesis of mucin-type O-glycans Inka Brockhausen, Queen's University, Ontario 19. Glycosylation in development Pamela Stanley, Albert Einstein College of Medicine, New York SECTION 7. Glycobiology and Medicine 20. Glycobiology of mucins in the human gastrointestinal tract Anthony Corfield, Mucin Research Group, University of Bristol 21. Mucosal glycoconjugates in inflammatory bowel disease and colon cancer Jon Rhodes, University of Liverpool 22. Selectin-mediated metastasis of tumor cells: Alteration of carbohydrate-mediated cell–cell interactions in cancers induced by epigenetic silencing of glycogenes Reiji Kannagi, Nagoya City University 23. Glycosphingolipids in health and disease Tony Futerman, Weizmann Institute of Science 24. Pathogen–host interactions in Entamoeba histolytica David Mirelman, Weizmann Institute of Science SECTION 8. Industrial Glycobiology 25. The development of iminosugars as drugs Bryan Winchester, Institute of Child Health 26. Carbohydrate biosensors Raz Jelinek, Ben Gurion University 27. Glycoanalysis on a lectin array: application to the development of biopharmaceuticals and life science research Rakefet Rosenfeld, Procognia 28. Lectin chips and CarboDeep™: a rapid carbohydrate fingerprinting technology and its application for the food scientists Ofer Markman, Nutricognia Afterword Nathan Sharon
£95.00
Cold Spring Harbor Laboratory Press,U.S. DNA Replication
Book Synopsis
£79.80
Cold Spring Harbor Laboratory Press,U.S. Protein Synthesis and Translational Control
Book Synopsis
£79.80
Cold Spring Harbor Laboratory Press,U.S. Signaling by Receptor Tyrosine Kinases
Book Synopsis
£79.80
Cold Spring Harbor Laboratory Press,U.S. Introduction to Protein-DNA Interactions:
Book Synopsis
£26.60
Cold Spring Harbor Laboratory Press,U.S. Calcium Techniques: A Laboratory Manual
Book Synopsis
£45.75
Cold Spring Harbor Laboratory Press,U.S. The Endoplasmic Reticulum
Book Synopsis
£79.80
Cold Spring Harbor Laboratory Press,U.S. Purifying and Culturing Neural Cells: A
Book Synopsis
£53.20
University Science Books,U.S. Mathematical Methods for Molecular Science:
Book SynopsisThis brilliant new text by John Straub (Boston University) is designed to bridge the “mathematics knowledge gap” between what is commonly known by students after completing a year of introductory calculus, and what is required for success in the physical sciences and in physical chemistry courses. Key concepts from the introductory calculus sequence are reviewed and carefully selected topics in multivariate calculus, probability and statistics, ordinary differential equations, and linear algebra are explored. Additional chapters cover advanced topics, including partial differential equations, Fourier analysis, and group theory. Engaging narratives, fully worked examples, hundreds of colourful visualizations, and ample end-of-chapter problems with complete answers combine to make this stunning new text an excellent choice for a one-semester course on mathematical methods, as a supplement for courses in physical chemistry, or as a self-study guide. Ancillaries for adopting faculty include in-class worksheets, sample exams, and an answer manual. Key features: Abundant end-of-chapter exercises, including three difficulty levels, with answers at the back of the book Ample worked examples throughout, with clearly explained steps to guide problem solving Reviews of all basic introductory calculus concepts before the introduction of new topics Over 400 original color figures to help visualize problem solving and interpretation of results Margin notes offering historical context and additional mathematical details Key ancillaries including in-class worksheets, sample exams, and an answer guide for adopting instructors Table of ContentsIntroduction 1 Functions and coordinate systems 2 Complex numbers and logarithms 3 Differentiation in one and many dimensions 4 Scalars, vectors, and vector algebra 5 Scalar and vector operators 6 Extremizing functions of many variables 7 Integration in one and many dimensions 8 Sequences, series, and expansions 9 Fundamentals of probability and statistics 10 Ordinary differential equations 11 More ordinary differential equations 12 Partial differential equations 13 Fourier series, Fourier transforms, and harmonic analysis 14 Matrices and matrix algebra 15 Eigenvalues and eigenvectors 16 Geometric transforms and molecular symmetry Bibliography; Index; Colophon
£58.49
John Libbey Eurotext Cytochrome P450: Biochemistry, Biophysics &
Book Synopsis
£62.89
John Libbey Eurotext Advances in Magnesium Research: New Data
Book SynopsisThis comprehensive treatise by international authorities will provide a major reference for all those interested in different aspects of magnesium. The last magnesium congress held in Romania gave the opportunity for extensive discussions and interchange of information between researchers from all over the world.
£39.94
Peter Lang AG Die Impfgegnerschaft in Hessen: Motivationen Und
Book SynopsisMit Inkrafttreten des Reichsimpfgesetzes 1874 formierten sich die latent vorhandenen Kritiker zu einer organisierten Impfgegnerschaft. Um deren Beweggründe, Argumente und die Verbindungen der Protagonisten untereinander zu erfassen, bietet sich ein regionaler Bezugsrahmen an. Er ermöglicht es, die individuellen Kontexte der Impf(zwang)gegner zu ermitteln, ihre Vernetzungen aufzudecken und zu zeigen, wie dieses Netzwerk arbeitete. Zudem wird untersucht, inwieweit die Impfgegner in Hessen in die zeitgenössische Lebensreformbewegung integriert waren.Moderne Impfkritiker, die über das World Wide Web vernetzt sind, tragen mit dazu bei, dass schwerwiegende Infektionskrankheiten wie Masern immer wieder ausbrechen.
£42.89
Prentice-Hall of India Pvt.Ltd Enzyme Technology: Pacemaker of Biotechnology
Book SynopsisThis textbook covers fundamental concepts of enzyme technology, emphasizing practical and economic aspects. It discusses enzyme properties, classifications, kinetics, and commercial potential. Applications in food and pharmaceutical industries are highlighted. Suitable for students, professionals, researchers, and entrepreneurs.
£999.99
PHI Learning Textbook of Biochemistry, Biotechnology, Allied
Book Synopsis
£65.25
Anmol Publications Pvt Ltd Physiology of Photosynthesis
Book Synopsis
£28.49
PeePee Publishers and Distributors Pvt Protein Energy Malnutrition: Volume 1
Book Synopsis
£5.85
Lotus Press Illustrated Dictionary of Bio Chemistry
Book SynopsisPresented in an easy to follow manner, this title proves useful to layman and professionals alike.
£6.18
Lippincott Williams & Wilkins Serie RT. Bioquímica, biología molecular y
Book SynopsisSerie RT. Bioquímica, biología molecular y genética presenta, en un formato conciso y sencillo, los temas y conceptos más importantes de bioquímica en un contexto fisiológico, incluyendo procesos de señalización celular, biología molecular, expresión y regulación génica, y un apartado de introducción a la genética humana. Cada capítulo cuenta con múltiples ilustraciones que, junto con el formato del texto, cubren los datos y conceptos que suelen preguntarse en los exámenes de la asignatura. Esta edición se basa en la 6.ª edición del texto, y aunque el orden de los capítulos es el mismo, todos han sido revisados y actualizados. También se han añadido trastornos adicionales en forma de correlaciones clínicas.
£999.99
Ovid Technologies LIR. Bioquímica
Book SynopsisElogiado por profesores y estudiantes durante más de dos décadas, Lippincott Illustrated Reviews. Bioquímica es uno de los mejores y más amigables textos de bioquímica para estudiantes de ciencias de la salud. Su contenido ayuda a los estudiantes a revisar, asimilar e integrar con rapidez grandes cantidades de información crítica y compleja, con el apoyo de ilustraciones que dan claridad a los conceptos.Table of ContentsUNIDAD I: Agua y estructura, y función de las proteínas Capítulo 1: Agua y pH Capítulo 2: Aminoácidos y la función del pH Capítulo 3: Estructura de las proteínas Capítulo 4: Proteínas globulares Capítulo 5: Proteínas fibrosas Capítulo 6: Enzimas UNIDAD II: Bioenergética y metabolismo de los carbohidratos Capítulo 7: Bioenergética y fosforilación oxidativa Capítulo 8: Introducción a los carbohidratos Capítulo 9: Introducción al metabolismo y la glucólisis Capítulo 10: Ciclo de los ácidos tricarboxílicos y el complejo piruvato deshidrogenasa Capítulo 11: Gluconeogénesis Capítulo 12: Metabolismo del glucógeno Capítulo 13: Metabolismo de monosacáridos y disacáridos Capítulo 14: La vía de la pentosa fosfato y del dinucleótido fosfato de nicotinamida y adenina Capítulo 15: Glucosaminoglucanos, proteoglucanos y glucoproteínas UNIDAD III: Metabolismo de los lípidos Capítulo 16: Metabolismo de los lípidos de la dieta Capítulo 17: Metabolismo de ácidos grasos, triacilglicerol y cuerpos cetónicos Capítulo 18: Metabolismo de fosfolípidos, glucoesfingolípidos y eicosanoides Capítulo 19: Metabolismo de colesterol, lipoproteínas y esteroides UNIDAD IV: Metabolismo del nitrógeno Capítulo 20: Aminoácidos: eliminación del nitrógeno Capítulo 21: Aminoácidos: degradación y síntesis Capítulo 22: Aminoácidos: conversión en productos especializados Capítulo 23: Metabolismo de nucleótidos UNIDAD V: Integración del metabolismo Capítulo 24: Efectos metabólicos de la insulina y el glucagón Capítulo 25: El ciclo alimentación-ayuno Capítulo 26: Diabetes mellitus Capítulo 27: Obesidad UNIDAD VI: Nutrición médica Capítulo 28: Nutrición: visión de conjunto y macronutrientes Capítulo 29: Micronutrientes: vitaminas Capítulo 30: Micronutrientes: minerales UNIDAD VII: Almacenamiento y expresión de la información genética Capítulo 31: Estructura, replicación y reparación del ADN Capítulo 32: Estructura, síntesis y procesamiento del ARN Capítulo 33: Síntesis de proteínas Capítulo 34: Regulación de la expresión génica Capítulo 35: Tecnologías del ADN y diagnóstico molecular de enfermedades humanas Capítulo 36: Coagulación de la sangre
£999.99
Ovid Technologies Marks. Bioquímica médica básica
Book SynopsisMarks. Bioquímica médica básica: Un enfoque clínico, 6.a edición, vincula la bioquímica con la fisiología y fisiopatología, permitiendo a los estudiantes aplicar con seguridad conceptos bioquímicos fundamentales para su práctica clínica, desde diagnóstico hasta recomendaciones terapéuticas eficaces. Este enfoque probado, centrado en la clínica, construye la aplicación de la bioquímica en torno a conceptos fisiológicos y fisiopatológicos relacionados para afianzar la comprensión en un contexto clínico desde el primer día. Los capítulos, organizados de forma intuitiva, se centran en viñetas de pacientes hipotéticos para enfatizar la aplicación clínica, y los útiles iconos, imágenes y preguntas de repaso facilitan la comprensión de conceptos complejos. Esta nueva edición ha sido revisada y mejorada de acuerdo con la retroalimentación recibida en la edición anterior; cada viñeta ha sido revisada y modificada para reflejar los lineamientos actuales de atención clínica; asimismo, se han añadido nuevos casos, actualizado los comentarios bioquímicos asociados con cada capítulo para permitir a los estudiantes evaluar hacia dónde se dirigen los esfuerzos de investigación actuales, y se ha aumentado el número de preguntas de autoevaluación. Table of ContentsCONTENIDOSSECCIÓN IMetabolismo de combustibles1 Combustibles metabólicos y componentes de la dieta2 Alimentación o estado de absorción3 AyunoSECCIÓN IIFundamentos químicos y biológicos de la bioquímica4 Agua, ácidos, bases y amortiguadores5 Estructuras de los principales compuestos del organismo6 Aminoácidos de las proteínas7 Relaciones estructurales y funcionales de las proteínas8 Enzimas como catalizadores9 Regulación de las enzimas10 Relación entre biología celular y bioquímica11 Señalización celular mediante mensajeros químicosSECCIÓN IIIExpresión génica y síntesis de proteínas12 Estructura de los ácidos nucleicos13 Síntesis de DNA14 Transcripción: síntesis de RNA15 Traducción: síntesis de proteínas16 Regulación de la expresión génica17 Uso de las técnicas de DNA recombinante en medicina18 Biología molecular del cáncerSECCIÓN IVMetabolismo de los carbohidratos, oxidación de combustible y la generación de trifosfato de adenosina19 Conceptos básicos en la regulación del metabolismo del combustible por la insulina, el glucagón y otras hormonas20 Bioenergética celular: trifosfato de adenosina y O221 Digestión, absorción y transporte de carbohidratos22 Generación de trifosfato de adenosina a partir de glucosa, fructosa y galactosa: glucólisis23 Ciclo del ácido tricarboxílico24 Fosforilación oxidativa y función mitocondrial25 Toxicidad del oxígeno y lesión por radicales libres26 Formación y degradación del glucógeno27 Vía de la pentosa fosfato y la síntesis de glucósidos, lactosa, glucoproteínas y glucolípidos28 Gluconeogénesis y mantenimiento de los niveles de glucosa en sangreSECCIÓN VMetabolismo de los lípidos29 Digestión y transporte de los lípidos de la dieta30 Oxidación de ácidos grasos y cuerpos cetónicos31 Síntesis de ácidos grasos, triacilgliceroles y principales lípidos de membrana32 Absorción, síntesis, metabolismo y destino del colesterol33 Metabolismo del etanol34 Integración del metabolismo de carbohidratos y lípidosSECCIÓN VIMetabolismo del nitrógeno35 Digestión de proteínas y absorción de aminoácidos36 Destino del nitrógeno de los aminoácidos: ciclo de la urea37 Síntesis y degradación de aminoácidos38 Tetrahidrofolato, vitamina B12 y S -adenosilmetionina39 Metabolismo de purinas y pirimidinas40 Relaciones entre tejidos en el metabolismo de los aminoácidosSECCIÓN VIIMetabolismo tisular41 Acciones de las hormonas que regulan el metabolismo energético42 Bioquímica de los eritrocitos y otras células de la sangre43 Proteínas del plasma sanguíneo, coagulación y fibrinólisis44 Metabolismo hepático45 Metabolismo del músculo en reposo y durante el ejercicio46 Metabolismo del sistema nervioso47 Matriz extracelular y tejido conectivo
£133.66
Ovid Technologies Bioquímica. Detrás de los síntomas
Book SynopsisBioquímica. Detrás de los síntomas adopta un enfoque de aprendizaje basado en problemas (ABP) y se centra en la aplicación práctica de la bioquímica para lograr resultados clínicos óptimos. El contenido está estructurado en torno a síntomas comunes encontrados por profesionales de la salud, establece conexiones claras entre la ciencia fundamental y las manifestaciones clínicas, y guía al lector hacia diagnósticos seguros a lo largo de su trayectoria profesional. Cada capítulo explora los conceptos bioquímicos subyacentes a las causas y demuestra sus vínculos con los síntomas que se presentan a través de casos clínicos reales de pacientes. Las preguntas que lo acompañan fomentan el debate y orientan a los usuarios en la elaboración de diagnósticos diferenciales precisos. Este enfoque es ideal tanto para entornos de aprendizaje colaborativo entre alumnos como para estudio independiente, fortalece la aplicación de conocimientos fundamentales y asegura una retención a largo plazo, esencial para el éxito clínico.Table of Contents1. Disnea 2. Ictericia 3. Diarrea 4. Hematomas 5. Fatiga 6. Retraso del crecimiento 7. Retrasos del desarrollo en la infancia y la niñez 8. Gota 9. Estado mental alterado 10. Obesidad Apéndice A. Preguntas de repaso y respuestas Apéndice B. Enfermedades en orden alfabético
£999.99
ANE Books Instant Biochemistry
Book Synopsis
£999.99
Jaypee Brothers Medical Publishers Essentials of Practical Biochemistry
Book SynopsisEssentials of Practical Biochemistry has been prepared in a user-friendly manner according to the requirements of medical, dental and paramedical students. Written in simple language, it provides all the relevant and essential information on various practical exercises that are required to be performed at undergraduate level. This textbook includes practical exercises on Qualitative Tests for Carbohydrates, Proteins, Amino Acids, Lipids and Non-protein Nitrogenous Substances, Qualitative and Quantitative Analysis of Urine, and of various Body Fluids, Quantitative Estimation of various metabolites like glucose, cholesterol, urea, creatinine, triglycerides, electrolytes, uric acid, albumin, etc. in serum/plasma, estimation of various Serum Diagnostic Enzymes, Organ Function Tests and Biochemical Techniques. For quick and easy understanding, the practical exercises have been described in several headings like Introduction, Principle, Materials/ Apparatus required, Procedure, Observations, Calculation and Result. In each practical exercise, a blank space has been provided for students to write down their own observations, readings and calculations. This textbook can therefore be used as a practical manual while working in the laboratory. Normally, students find difficulty in understanding the procedure and calculation portions of the quantitative practical exercises. To overcome this problem, procedure and calculation portions of most exercises have been simply explained with examples and space for calculation provided. For practice before examination, Test Exercises and Model Papers have also been provided. A list of reagents and solutions along with the procedures of their preparation and normal biochemical values required for routine clinical practice have also been given.Table of ContentsSection I Qualitative Tests for Carbohydrates, Proteins, Amino Acids, Lipids and Nonprotein Nitrogenous Substances Section II Qualitative and Quantitative Analysis of Urine Section III Qualitative and Quantitative Analysis of Body Fluids Section IV Quantitative Estimations in Serum/Plasma Section V Estimation of Serum Diagnostic Enzymes Section VI Organ Function Tests Section VII Techniques Section VIII Miscellaneous Index
£32.30
World Scientific Publishing Co Pte Ltd High Dilution Effects On Cells And Integrated
Book SynopsisHigh dilution effects constitute a major problem on the frontier of biophysics. The reported effects on simple and complex biological systems range from in vitro and in vivo models to cellular metabolism regulation, the immune system, the nervous system, intoxicated organs and organisms, and developmental models. The physical properties of high dilutions have been considered, such as the organization properties of water molecules in the presence and after the presence of solute molecules, the energy characteristics of empty and full water clusters, and their dynamical interactions with proteins. Among the mechanisms responsible for the high dilution effects, a non-molecular transfer of information has been hypothesized.Table of ContentsIntroductory lecture: Basic research on high dilution effects, M. Bastide. Biophysical aspects: Hormesis, M. Oberbaum; Effects of metal high dilutions on cells and integrated systems, J. Cambar et al; Coherence in biological systems and water, C.W. Smith. Clinical evidences: High dilutions as a tool of immunomodulation, M. Bastide; Supersensitivity of the rat lens in a critical period of the development, K. Muranov; Use of high-diluted drugs for dream recall in psychotherapy, S. Sportiello. Structure and communication: Structure-function properties of water clusters in proteins, D. Arad; Experimental detection of the existence of structures in high dilutions, G.S. Anagnostatos; Pharmacological frequency transfer on animal and vegetal model, C. Vinattieri et al. (Part contents).
£999.99
