Pharmacology Books

Book SynopsisTable of Contents1. Overview of Biotherapeutics and Vaccine Industry 2. Industrial Process Design Concepts 3. Single-Use Concepts in Manufacturing 4. Equipment and Automation 5. Facility Design 6. Process Development Routines 7. Production Sources and their Selection 8. Upstream Processing 9. Downstream Processing 1: Recovery Process 10. Downstream Processing 2: Purification Process 11. Downstream Related Methods 12. Analytics 13. Regulatory Aspects 14. Manufacturing Operations 15. Economics

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Book SynopsisTable of ContentsSection I. Applications of nutraceuticals in common diseases and disorders 1. Nutraceuticals in central nervous system diseases: potential mechanisms of neuroprotection 2. Prevention of neurodegenerative disorders by nutraceuticals 3. Cognitive effects of nutraceuticals 4. Nutraceuticals in anxiety and stress 5. Countering cardiovascular diseases with nutraceuticals 6. Nutraceuticals for diabetes and glucose balance 7. Role of nutraceuticals in respiratory and allied diseases 8. Nutraceuticals in hepatic diseases 9. Nutraceuticals in renal diseases 10. Nutraceuticals in gastrointestinal disorders 11. Nutraceuticals in reproductive and developmental disorders 12. Nutraceuticals in ophthalmic diseases 13. Nutraceuticals in dermal diseases 14. Nutraceuticals in arthritis 15. Nutraceuticals in sports activities and fatigue 16. Role of nutraceuticals as adaptogens 17. Nutraceuticals for weight loss 18. Nutraceuticals in cancer prevention 19. Application of “nano” nutraceuticals in medicine Section II. Models and mechanisms in evaluation of nutraceuticals 20. The biology of nutrients: genetic and molecular principles 21. Genomic and proteomic mechanisms and models in toxicity and safety evaluation of nutraceuticals 22. Transcriptomic profiling for safety and toxicity evaluation of nutraceuticals 23. Target identification and polypharmacology of nutraceuticals 24. Systems pharmacology investigation of mechanism of action of nutraceuticals 25. Noninvasive in vivo optical imaging models for safety and toxicity testing 26. Flow cytometry and light-scattering techniques in evaluation of nutraceuticals 27. Zebrafish as a model system to evaluate the safety and toxicity of nutraceuticals 28. Caenorhabditis elegans: an elegant model organism for evaluating the neuroprotective and neurotherapeutic potential of nutraceuticals 29. Alternative in vitro models for safety and toxicity evaluation of nutraceuticals 30. Mitochondria as a target for safety and toxicity evaluation of nutraceuticals 31. Oxidative stress and excitotoxicity: antioxidants from nutraceuticals Section III. Common nutraceuticals 32. Caffeine: an evaluation of the safety database 33. Biological activities and potential nanotechnological delivery of resveratrol 34. Melatonin: a safe nutraceutical and clinical agent 35. Standardized turmeric and curcumin 36. Curcuminoid-metal complexes for oxidative stress 37. Fenugreek: multiple health benefits 38. Cannabis sativa: an overview 39. Cannabidiol safety 40. St John’s wort (Hypericum perforatum L) 41. Green tea 42. Green coffee beans 43. Quercetin 44. German chamomile 45. Isoflavones: toxicological aspects and efficacy 46. Propolis 47. Bee products as nutraceuticals to nutraceuticals for bees 48. Ginkgo biloba 49. Chinese ginseng 50. Ashwagandha: multiple health benefits 51. Astaxanthin: health benefits and toxicity 52. Thymoquinone 53. Glucosinolates 54. Organosulfur compounds as nutraceuticals 55. Arginine and citrulline as nutraceuticals: efficacy and safety in diseases 56. Neem Extract 57. Spirulina 58. Garcinia cambogia 59. Vitamin E TPGS and its applications in nutraceuticals 60. Role of transferrin: an iron-binding protein in health and diseases 61. Glutamine supplementation: hope, hype, or stay tuned? 62. What to do with placenta after birth: is it a waste? 63. Chitin, chitosan, and their derivatives Section IV. Prebiotics and probiotics 64. Prebiotics: safety and toxicity considerations 65. Probiotics: safety and toxicity considerations 66. Synbiotics: safety and toxicity considerations Section V. Nutraceuticals in veterinary medicine 67. Nutraceuticals in animal health and diseases Section VI. Toxicity and toxic interactions 68. Toxic contamination of nutraceuticals and food ingredients 69. Nutraceuticals and adverse outcome pathways 70. Interactions between nutraceuticals/nutrients and nutrients and therapeutic drugs 71. Genotoxicity evaluation of nutraceuticals Section VII. Regulatory aspects 72. The regulatory framework for nutraceuticals: North America 73. Evaluation and regulation of food supplements: European perspective 74. Regulatory guidelines for nutraceuticals in India: an overview 75. Regulatory aspects of nutraceuticals: Chinese perspective 76. Uses and regulation of nutraceuticals: Australia and New Zealand 77. Regulatory aspects of nutraceuticals: Japanese perspective 78. Nutraceuticals: the Turkish perspective

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Book SynopsisTable of ContentsPharmacology Flash Cards Fourth Edition Section I: Autonomic, Autacoid, and Neuromuscular Drugs Section II: Cardiovascular Drugs Section III: Lipid, Coagulation, and Hematopoiesis Drugs Section IV: Central Nervous System Depressant Drugs Section V: Psychotherapeutic Drugs Section VI: Analgesic and Antimigraine Drugs Section VII: Neurodegenerative Disease Drugs and Antidotes Section VIII: Anesthetic Drugs Section IX: Gastrointestinal Drugs Section X: Respiratory Drugs and Antihistamines Section XI: Musculoskeletal Drugs Section XII: Endocrine Drugs Section XIII: Antibacterial Drugs Section XIV: Antifungal, Antiviral, and Antiparasitic Drugs Section XV: Antineoplastic And Immunosuppressant Drugs

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Book SynopsisTable of Contents1. Therapeutic Applications of Polymeric Materials 2. Multifunctional Micro- and Nanoparticles 3. Nanomicelles in Diagnosis and Drug Deliver 4. Diagnosis and Drug Delivery to the Brain: Novel Strategies 5. Emerging Nanotechnology for Stem Cell Therapy 6. Nanoparticulate Systems for Therapeutic and Diagnostic Applications 7. Peptide and Protein-Based Therapeutic Agents 8. Nanotechnology in Intracellular Trafficking, Imaging, and Delivery of Therapeutic Agents 9. Electrospun Nanofibers in Drug Delivery: Fabrication, Advances, and Biomedical Applications 10. Nanosystems for Diagnostic Imaging, Biodetectors, and Biosensors 11. Micro- and Nanotechnology-Based Implantable Devices and Bionics 12. Solid Lipid Nanoparticles in Drug Delivery: Opportunities and Challenges 13. Microneedles in Drug Delivery 14. Nanotechnology-Based Medical and Biomedical Imaging for Diagnostics 15. Drug and Gene Delivery Materials and Devices

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Book SynopsisTable of ContentsUnit A: Basic Concepts and Principles in Pharmacology 1 Introduction to Respiratory Care Pharmacology 2 Principles of Drug Action 3 Administration of Aerosolized Agents 4 Calculating Drug Doses 5 Central and Peripheral Nervous Systems Unit B: Drugs Used to Treat the Respiratory System 6 Adrenergic (Sympathomimetic) Bronchodilators 7 Anticholinergic (Parasympatholytic) Bronchodilators 8 Xanthines 9 Mucus-Controlling Drug Therapy 10 Surfactant Agents 11 Corticosteroids in Respiratory Care 12 Nonsteroidal Antiasthma Agents 13 Aerosolized Antiinfective Agents 14 Antimicrobial Agents 15 Cold and Cough Agents 16 Selected Agents of Pulmonary Value 17 Neonatal and Pediatric Aerosolized Drug Therapy Unit C: Critical Care, Cardiovascular, and Polysomnography Agents 18 Skeletal Muscle Relaxants (Neuromuscular Blocking Agents) 19 Diuretic Agents 20 Drugs Affecting the Central Nervous System 21 Vasopressors, Inotropes, and Antiarrhythmic Agents 22 Drugs Affecting Circulation: Antihypertensives, Antianginals, Antithrombotics 23 Sleep and Sleep Pharmacology Appendixes A Answers to Self-Assessment Questions and Clinical Scenarios B Units and Systems of Measurement C Acceptable Mixtures of Most Commonly Prescribed Respiratory Care Drugs Glossary of Selected Terms Index Abbreviations, Inside back cover

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Book SynopsisTrade Review"Henson and Resta have compiled a thorough catalogue of clinically important cancer genes in a novel, accessible format that takes it to another level." --Jeffrey N. Weitzel, MD, Oncogenomicist for Precision PreventionTable of ContentsI. Genetics II. Genetic Testing III. Clinical Features IV. Tumors - Syndromes - Genes V. Classic Hereditary Cancer Syndromes

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Book SynopsisIf you understand how drugs work (pharmacodynamics), how they are handled by the body (pharmacokinetics), how they interact with each other, and how drug treatments are assessed, then you will become a better prescriber. A Textbook of Clinical Pharmacology and Therapeutics gives you that understanding.Fully revised throughout and extensively illustrated, the fifth edition of this well-established textbook has been streamlined to focus on what medical students and junior doctors really need to know in order to understand the implications of prescribing one drug over, or in combination with, another. The text provides current information on all areas of drug prescribing with updated discussion and guidance on such topics as adverse drug reactions, ''personalized medicine'', gene and cell-based therapy, advances in cancer therapy, and mechanisms of drug action and treatment guidelines in HIV and mycobacterial infections therapy. A new chapter on alternative meTrade Review"This is an excellent source for medical students and young doctors who are learning the art of using drugs in medical practice."—Thomas L. Pazdernik (University of Kansas), Doody's Publishing Service"If you only buy one clinical pharmacology textbook for medical school, make it this one."—Oxford Medical School GazetteTable of ContentsPart 1 General principlesPart 2 The nervous systemPart 3 The musculoskeletal systemPart 4 The cardiovascular systemPart 5 The respiratory systemPart 6 The alimentary systemPart 7 Fluids and electrolytesPart 8 The endocrine systemPart 9 Selective toxicityPart 10 HaematologyPart 11 ImmunopharmacologyPart 12 The skinPart 13 The eyePart 14 Clinical toxicology

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Book SynopsisUnderstanding the biotransformations of aromatic compounds and how they metabolize in animals, plants, and microbes, is central to the applications in a wide range of industries, such as the design and testing of natural and synthetic pharmaceuticals, oil refining, the development of agrochemicals, bioremediation, and for use in functional genomics and xenobiotics. Presenting the most complete resource of its kind, the Handbook of Biotransformations of Aromatic Compounds examines 20,000 aromatic compounds researched since 1972, and assembled from all the major, relevant journals. The author focuses his coverage on the biotransformation in animals, plants, and microbes while remaining within the scope of aromatic compounds that contain, or are fused with, at least one aromatic C6 ring. Part One lists each compound alphabetically along with the forward and reverse mechanisms of its metabolism in specific organisms. Part Two characterizes the different types of organic reactions tTrade Review"The book is indispensable for my work, and for researchers involved in a variety of fields in academia and industry…The author is a world authority on the subject…I HIGHLY recommend this book…" - Dr. Iqbal Gill, Head of Biotransformations/Biocatalysis Department, Roche Vitamins Inc."…a well-structured book covering the literature of the last thirty years….easy to use and contains plenty of interesting material…contains an immense amount of information on themetabolism of aromatic compounds." ChemBioChem 2005, volume 6 "This book is an excellent and exhaustive source…a labour of love which should prove to be an essential reference source for those involved in the biotransformation of aromatics as it provides detailed coverage of developments within this field over the past 100 years." biochemist.org, July 8, 2005Table of ContentsReactions Involving the Formation and Degradation of The Aromatic Nucleus. Oxidations and Reductions Involving the Aromatic Nucleus and Non-Organic Substituents. Oxidations and Reductions of Substituent Side Chains and Non-Aromatic Ring Systems (Without Altering Chain Length). Formation and Degradation of Side-Chains. Side-Chain Formation. Conjugation and Substitution Reactions. Elimination of Substituents. Transfer Reactions. Formation and Reactions of Non-Aryl Double and Triple Bonds. Hydration of Epoxides. Light-Forming Reactions.

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Book SynopsisCellular proteinases and their physiological role in normal and disease states have been the subject of great interest over recent decades. At present, specific protease inhibitors are exploited both as tools in unraveling the role of individual proteinases in particular cellular processes and for the development of chemotherapeutic agents for the treatment of various disorders. Proteinase and Peptidase Inhibition presents updated progress reports on the characterization of a wide range of cellular proteinases whose inhibitors may hold the key to the development of new drugs. Introductory chapters deal with the broad enzyme classes, inhibitor types and regulatory mechanisms governing proteinase activity. The target enzymes themselves, together with all aspects of their inhibition and inhibitor design, are comprehensively described. The classification of target enzymes by structural similarity, rather than by pharmacological effects, provides a new and coherent platform for understandinTable of ContentsEnzyme Classes and Mechanisms. Regulatory Mechanisms for Proteinase Activity. Matrix Metalloproteinases (MMPs). Proteasomes. Cathepsins. Calpain. Human Neutrophil Elastase Inhibitors. Thrombin. Inhibitors of Factor VIIa, Factor IXa, and Factor Xa as Anticoagulants. The Urokinase-Type Plasminogen Activator (uPA) System: A New Target for Tumor Therapy. Proteinases Involved in Amyloid ß-Peptide (Aß) Production and Clearance. Herpes Virus and Cytomegalovirus Proteinase. Human Rhinovirus 3C Proteinase Inhibitors. Aminopeptidases. The Hepatitis C Virus NS3 Serine-Type Proteinase. Zinc Metallopeptidases. HIV Aspartate Proteinase: Resistance to Inhibitors. Proteases of Protozoan Parasites for Proteinase Activity.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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Book SynopsisTrade ReviewWhether you are an experienced health care professional working in the field of diabetes technology or fairly new to it all, 'Insulin Pumps and CGM made easy' will provide you with excellent insights into how to get the most from these technologies. This is a 'must have' for the book shelf of those working with people who have Type 1 diabetes. Dr Emma Wilmot, Chair ABCD Insulin Pump Network UK, Consultant Diabetologist, DerbyTable of Contents1 An introduction to insulin pumps. 2 Mastering the insulin pump. 3 An introduction to continuous glucose monitoring. 4 Interpretation of continuous glucose monitoring recordings. 5 How healthcare professionals can support people with diabetes to make best use of continuous glucose monitoring. 6 Glucose profile in normal and well-controlled diabetic patients. 7 Abnormalities of glucose profile at night. 8 Abnormalities of glucose profile in relatino to food. 9 Abnormalities of glucose profile in relation to activity. 10 Using continuous glucose monitoring to manage difficult diabetes cases. 11 Sensor-augmented pump therapy.

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Book SynopsisTable of Contents1 Cardiovascular systemAntiarrhythmic drugsCardiac glycosidesCalcium channel blockersß-blockersAntihypertensives2 Blood/coagulation systemAnticoagulantsAntiplatelet drugsLipid-lowering agents3 Hormonal systemOral antidiabeticsInsulinsThyroid hormonesIodized salts4 Respiratory systemAntitussive agentsExpectorants5 Renal/urinary systemDiuretics6 Gastrointestinal systemAntiemetic agentsAntiulcerantsAntidiarrhoeal agentsLaxativesAntispasmodic (spasmolytic) agents7 Immune systemAntibioticsAntiviral agentsAntimycotic (antifungal) agentsAntiallergic agents8 Central nervous systemAnalgesicsHypnotic agentsAntidepressantsParkinson's diseaseAnxiolytic agentsNeuroleptic agents

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Book SynopsisIbuprofen is widely used throughout the world for a variety of conditions. This reference work provides a comprehensive and critical review of the basic science and clinical aspects of the drug. The book begins with the history and development of the drug and its current patterns of use world- wide before moving on to examine its basic pharmaceutical attributes and medicinal chemistry. The properties of various formulations are described (oral prescription and OTC, topical and others) are described. The pharmacokinetics of ibuprofen in animals and humans is discussed - highlighting the factors affecting absorption, distribution, metabolism and elimination. The clinical pharmacology and toxicology and the drug's mechanisms of action in different disease states and conditions are covered. The therapeutic uses in various acute and inflammatory conditions is detailed. Also considered are the safety versus efficacy issues and the pharmacoepidemiological data.Table of Contents1. History and Development of Ibuprofen K.D. Rainsford 2. The Medicinal Chemistry of Ibuprofen K.J. Nichol 3. The Pharmaceutics of Ibuprofen F. Higton 4. The Pharmacokinetcs of Ibuprofen in Humans and Animals D.R. Brocks and F. Jamaili 5. Pharmacology and Toxicology of Ibuprofen K.D. Rainsford 6. Therapeutics of Ibuprofen in Rheumatic and Other Chronic and Painful Diseases W.F. Kean, W.W. Buchanan and K.D. Rainsford 7. Safety and Efficacy of Non-Prescription (OTC) Ibuprofen K.D. Rainsford 8. Use of Ibuprofen in Dentistry R.A. Dionne and S.A. Cooper 9. Gastrointestinal Adverse Drug Reactions Attributed to Ibuprofen D.A. Henry, A. Drew and S. Beuzeville 10. Renal Effects of Ibuprofen M.D. Murray and D.C. Brater 11. Adverse Drug Reactions Attributed to Ibuprofen: Effects Other Than Gastrointestinal L.J. Miwa and J.K. Jones 12. Human Toxicity of Ibuprofen G.N. Volans and R. Fitzpatrick Nichol, Boots Pharmaceuticals, UK, F. Higton, Boots Healthcare International, D.R. Brock, Western University of Health Sciences, USA, F. Jamaili, University of Alberta, USA, W.F. Kean, McMaster University, Canada, W.W. Buchanan, Sir William Osler Health Institute, Canada, R.A. Dionne, National Istitute of Health, USA, S.A. Cooper, Whitehall-Robins Health Care, USA, D.A. Henry, Newcastle Mater Hospital, Australia, A. Drew, Newcastle Mater Hospital, Australia, S. Beuzeville, Newcastle Mater Hospital, Australia, M.D. Murray, Regenstrief Health Centre, USA, D.C. Brater, Indiana university School of Medicine, USA, L.J. Miwa, The Degge Group, USA, J.K. Jones, The Degge Group, USA, G.N. Volans, Guys and St. Thomas' Hospital Trust, UK, R. Fitzpatrick, Guys and St. Thomas' Hospital Trust, UK.

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Book SynopsisThe book provides an exhaustive, authoritative and updated review on the interindividual variability in drug metabolism in humans. Four chapters address the general background: genetic factors causing variability, interethnic variability, environmental factors and developing and ageing as sources of variability. Six chapters address variability of drug metabolism in vivo: variability of psychotropic drugs, antiepileptic drugs, the dopamine precursor levodopa, cardiovascular active drugs and anti HIV drugs. Seven chapters address the interindividual variability of the main drug metabolizing enzymes: CYP-450s, acetyltransferases, glucuronosyl transferase, methyl transferases, sulfotransferases and glutathione transferases in human liver and extrahepatic tissues. A separate chapter discusses the prediction of drug interaction.Comprehensive in coverage, and with contributions from the leading international experts, this book is essential reading for researchers from both academiTable of ContentsGenetic Factors That Cause Variability in Human Drug Metabolism. Interethnic Differences in Drug Disposition and Effects. Developing and Ageing as Sources of Variability in Drug Metabolism. Genetic and Environmental Factors Causing Variability in Psychotropic Drug Response. Interindividual Variability in the Metabolism of Cardiovascular Drugs. Interindividual Variability in the Metabolism of Antiepileptic Drugs and its Clinical Implications. Variability in the Metabolism of Levodopa and its Clinical Implications. Interindividual Variability in the Disposition of Anti-HIV Drugs. Predictive Modeling of in vivo Drug Interaction From in vitro Data: From Theory to a Computer-based Workbench and Experimental Validation. Interindividual Variation of P450 Enzymes in vitro and it's Causes. Interindividual Variability of Arylamine N-acetyltransferases. Interindividual Variation of UDP-glucuronosyl Transferases and Drug Glucuronidation. Interindividual Variability of Methyltransferases. Interindividual Variability of Sulpho Transferases. Interindividual Variability of Glutathione Transferase Expression

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Book SynopsisReviewing over a century of aspirin research and use, Aspirin and Related Drugs provides a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination, and future uses of aspirin.Highlighting the historical evolution of the salicylates and the commercial development of aspirin, the book reviews the pharmacokinetics of the salicylates, ibuprofen, and paracetamol as a basis for understanding the biodisposition of these analgesic drugs. Leading specialists discuss the therapeutic role of aspirin in the prevention and treatment of thrombo-embolic diseases, its place along with non-acetylated salicylates in the treatment of rheumatic diseases and plain, and the potential applications for aspirin and related drugs as prophylactics for colon cancer, Alzheimer's disease, and vascular dementia. They also present comparisons with other drugs used to treat pain and inflammation.With extensive data and literTable of ContentsHistory and Development of the Salicylates. The Industrial History of Analgesics: The Evolution of Analgesics and Antipyretics. Occurrence, Properties and Synthetic Developments of the Salicylates. Pharmacokinetics and Metabolism of the Salicylates. Metabolism and Pharmacokinetics of Ibuprofen. Pharmacokinetics and Metabolism of Paracetamol (Acetaminophen). Pharmacology and Biochemistry of Salicylates and Related Drugs. Side-effects and Toxicology of the Salicylates. Reye's Syndrome and Aspirin. Salicylates in the Treatment of Acute Pain. Acetysalicylic Acid for the Prevention and Treatment of Thromboembolic Diseases. Use of Salicylates in Rheumatic and Related Conditions. Aspirin and NSAIDs in the Prevention of Cancer, Alzheimer's Disease and other Novel Therapeutic Actions.

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Book SynopsisStroke is the third leading cause of death in the USA and UK. It is a major cause of disability among adults and is a significant factor in dementia in later life and its incidence is on the rise. This book discusses specific medications that target the blood and vasculature and how these treatments can be used to complement other therapeutic measures, such as carotid endarterectomy. It covers the pharmacological methods used to address the risk factors in stroke, the major drug discoveries of recent years--antiaggregant, antithrombotic, and anticoagulant therapies--and also long established therapies such as aspirin and warfarin. With contributions by internationally recognized experts, this is a unique single source of information on current pharmacological prevention of stroke.Table of Contents1. Stroke Prevention in 2000 J. Easton 2. Primary vs. Secondary Stroke Prevention P. Gorelick 3. Aspirin P. De Moerloose 4. Ticlopidine and Clopidogrel M. Paciaroni 5. Other Anti-platelet Agents A. Culebras 6. Dipyridamole H. Diener 7. New Antiplatelet Agents B. Weksler 8. Clinical Use of Antiplatelet Agents for Stroke Prevention G. Donnan 9. Antithrombotic Therapy Before and After Carotid Endarterectomy H. Barnett 10. Anticoagulants T. Moulin 11. Early Prevention of Stroke Recurrence M. Brown 12. Lipid Lowering Agents and Stroke Risk P. Amarenco 13. Stroke Prevention With Blood Pressure Control P. Bath 14. Antioxidants, Vitamins D. Spence 15. Estrogen Replacement L. Brass 16. Healthcare Issues, Benefits and Costs G. Hankey Gorelick, Centre for Stroke Research, USA, Babette Weksler, Cornell University, USA, Geoffrey Donnan, National Stroke Research Institute, Australia, H. Barnett, Robarts Research Institute, Canada, Martin Brown, University of London, UK, Pierre Amarenco, Hospital Lariboisere, France, Phillipe Bath, Nottingham City Hospital, UK, J. David Spence, Robarts Research Institute, Canada, Graeme Hankey, Royal Perth Hospital, Australia, H. Diener, Neurologische Uniklinik, Germany, Lawrence Brass, Yale University School of Medicine, USA, Thierry Moulin, Hospital Regional de Bescancon, Maurizio Paciaroni, University of Perugia, Italy, Antonio Culebras, VA Medical Centre, USA, Phillipe de Moerloose, HUG, Geneva.

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Book SynopsisThe story of the one woman who, against all odds, stopped Thalidomide in its tracks because it poisoned a nation

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Book SynopsisThis book is a compilation of the recent applications of palladium catalysts in organic synthesis. The book demonstrates that it is a highly dynamic research field. This methodology has emerged as a powerful tool for the efficient and chemoselective synthesis of heterocyclic molecules. In the past few years, several strategies have been pointed out to pursue more efficient, sustainable, and environment friendly chemical processes. Among those strategies, catalysis and the design of new processes that avoid the use of toxic reagents have been the focus of intense research.Trade Review'The book “Palladium Assisted Synthesis of Heterocycles” presents a thorough compilation of modern palladium-catalysed synthetic methodologies aimed at accessing heterocycles of various nature and size. It is well-structured and written and covers literature extensively for the last two decades of research in the field. The book is highly recommended to all medicinal chemists who are interested in incorporating heterocycles into their lead molecules and are looking for a concise synthetic approach to making them. It is also recommended to all process chemists who are developing expedient and reliable methods aimed at accessing heterocyclic molecules.From my personal perspective, the book is clearly written, concise and easy to read.'— Fedor Romanov Michailidis, Johnson Matthey Technol. Rev., 2021, 65, (3), 496Table of ContentsPalladium catalyzed synthesis of heterocycles: An Introduction. Five-membered N-heterocycles. Five-membered N-polyheterocycles. Five-membered fused N-heterocycles. Five-membered N, N-heterocycles. Five-membered poly and fused O-heterocycles. Five-membered O,N-heterocycles. Six-membered N-heterocycles. Six-membered N-polyheterocycles. Six-membered fused N-heterocycles. Six-membered N, N-heterocycles. Seven-membered heterocycles.

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Book SynopsisThis volume illustrates the impact of environmental oxidants on the tissues of the eyes, lungs and skin, as well as on the immune system - highlighting common illnesses, injuries and pathologies induced by pro-oxidant environmental xenobiotics such as inflammation, immune response, signal transduction, regulation of gene expression, and carcinogenesis. It provides clinical presentations and discusses the effects of environmental oxidants on target organs.Table of ContentsMolecular and cellular aspects of pro-oxidant environmental xenobiotics: free radical reactions in human disease; radicals and inflammation - mediators and modulators; autoimmunology caused by oxidising foreign compounds; role of oxidative stress in chemical carcinogenesis; proposed mechanisms of arsenic toxicity carcinogenesis; redox regulation of gene expression and transcription factors in response to environmental oxidants. Target organs of environmental oxidants - lung: cigarette smoking and pulmonary oxidative damage; the health effects of diesel exhaust and diesel exhaust particles; the role of free radicals in asbestos- and silica-induced fibrotic lung diseases; reactive oxygen and silica-induced carcinogenesis; atmospheric oxidants and respiratory tract surfaces. Target organs of environmental oxidants - skin: redox modulation and oxidative stress in dermatotoxicology; dermatotoxicology of environmental and occupational hazards - agents and action; photo-oxidative stress in skin and regulation of gene expression; ozone induces stress in the skin barrier; immunotoxicology of oxidizing chemicals in the skin. Target organs of environmental oxidants - eye: environmental stressors and the eye - an overview; free radicals and ageing of anterior segment tissues of the eye; the role of ocular free radicals in age-related macular degeneration; nutritional influences on risk for cataract.

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Book SynopsisExploring the role of Immunoglobulin-E (IgE) in human disease, this reference summarizes current research on the mechanisms and utilization of anti-IgE therapeutics in the treatment of IgE-mediated allergic disease, inflammation, and asthma-discussing the structural composition of high- and low-affinity IgE receptors, the airway cells that express these receptors, and the functional activity of IgE-FceRI and IgE-FceRII interactions for improved control and management of allergic disorders.Compiles previously unpublished data from the first extensive scientific investigations of Xolair!IgE and Anti-IgE Therapy in Asthma and Allergic Diseasereviews studies on the distribution of serum IgE levels of normal and asthmatic populations in developed regions of the world such as the United States, Canada, Scandinavia, New Zealand, and Europe offers novel methods for the design and formulation of monoclonal antibodies discusses the use of allergeTable of ContentsIntroduction James D. Reimann, Sharon Safrin, and Robert B. Fick, Jr.Understanding the Binding of IgE to Its High-Affinity Receptor and to an Anti-IgE AntibodyLeonard G. Presta and Robert L. ShieldsMediator Release from Basophils and Mast Cells and Its Relationship to FceRI Expression and IgE-Suppressing TherapiesDonald W. MacGlashan, Jr., John T. Schroeder, Lawrence M. Lichtenstein, Sarbjit S. Saini, and Bruce S. BochnerExpression of IgE Receptors on Eosinophils David Dombrowicz, André Capron, and Monique CapronEosinophil IgE Receptors: Controversy and Consensus Hirohito Kita and Cheryl R. AdolphsonMurine Models of Asthma: Caveats and Conclusions on the Contribution of IgE and Mast Cells to Allergic Inflammation, Airway Hyperresponsiveness, and Airflow ObstructionJeffrey S. Tepper and Daniel B. TumasRole of IgE in Asthma: Pathogenesis and Novel Therapeutic StrategiesJames Laurence Lordan, Stephen T. Holgate, and Ian SayersIgE-Mediated Response to Allergen in the Bronchoprovocation LaboratoryLouis-Philippe Boulet and Donald W. CockcroftPathophysiology of the Airway Response to Inhaled Allergen in Asthmatic Subjects: Role of IgEJohn V. FahyEfficacy and Safety of Xolair Anti-IgE Monoclonal Antibody in Adult AsthmaticsRobert B. Fick, Jr., and W. James MetzgerThe Role of IgE in Pediatric Asthma Henry Milgrom and Charles JohnsonAnti-inflammatory Activities of Omalizumab (Xolair), a Recombinant Humanized Monoclonal Antibody Binding IgERobert B. Fick, Jr.Pulmonary Delivery of Anti-IgE: Rationale for Topical Delivery to the AirwayTheresa D. Sweeney, Melinda Marian, Jane Ruppel, and Jeanine L. BussiereTreatment of Seasonal Allergic Rhinitis Thomas B. Casale and Patricia W. RohaneAnti-IgE and Allergic Skin Diseases Michaël F. Hofer and Donald Y. M. LeungRole of IgE and Food Allergens Ricki M. Helm and A. Wesley BurksRole of IgE in Allergic Bronchopulmonary Aspergillosis Priscilla S. A. Sarinas and Rajinder K. ChitkaraIgE and Its Role in Parasitic Helminth Infection: Implications for Anti-IgE-Based TherapiesPhilip J. Cooper and Thomas B. NutmanThe Rise of Antibodies as Therapeutics Maureen P. Quan and Paul CarterAuthor Index

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Book SynopsisResponding to the explosion of advances in the use of biomarkers to efficiently, rapidly, and economically evaluate the health effects of chemical entities, this authoritative reference provides a detailed overview of the theory, development, and practical application of biomarkers in the toxicological, environmental, forensic, and pharmaceutical sciences. Compiling the most recent studies on the generation and utilization of biomarkers for toxicant exposure, environmental and human health risk assessment, occupational safety, drug development, and the detection of biological and chemical warfare agents, this guide supplies numerous examples, figures, tables, and comprehensive reference listings within each chapter to provide the reader with an in-depth understanding of the subject.Table of ContentsIntroduction to Toxicologic Biomarkers. Challenges in the Statistical Analysis of Biomarker Data. Biomarkers of Toxicant Exposure. Biomarkers in Environmental Epidemiology. Use of Biomarkers in Health Risk Assessment. Biomarkers of Toxicant Susceptibility. Identification and Use of Biomarkers in Preclinical Toxicologic Safety Assessment. Use of Biomarkers in Clinical Toxicology and Clinical Trials. Regulatory Guidance and Validation of Toxicologic Biomarkers. Use of Biomarkers in Occupational Safety and Health. Toxicogenomic and Toxicoproteomic Approaches for Biomarkers. Biomarkers of Chemical Warfare Agent Exposure. Applications of Biomarkers in Toxic Tort and Forensic Litigation

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Book SynopsisLaboratory automation is an increasingly important part of the job description of many laboratory scientists. Although many laboratory scientists understand the methods and principles involved in automation, most lack the necessary engineering and programming skills needed to successfully automate or interface equipment in the lab. A step-by-step, how-to reference and guide, Practical Pharmaceutical Laboratory Automation explores the processes needed to automate the majority of tasks required in research today. The author discusses topics ranging from automated mathematical analysis to robotic automation of chemical processes, to combinations of these and other processes. He presents a detailed discussion of high throughput screening and assay development and takes an in-depth look at Visual Basic as the primary programming language used in laboratories. The text has a dedicated web site (http://www.pharmalabauto.com) that contains all the sample code and examples contained witTable of ContentsIntroduction. Microsoft Excel Visual Basic Macros Running VBA Macros in Excel. Advanced Microsoft Excel VB Macro Techniques. Robotic Automation Using Visual Basic. Low Level Hardware Interfacing Using VB. Electronics for Automation. Robust Data Analysis Using Origin Lab's Origin. Agilent (HP) Chemstation Macro Writing. Appendices.

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Book SynopsisA user-friendly guide for the evaluation of microbiological assays, Microbiological Assay for Pharmaceutical Analysis: A Rational Approach provides a lucid explanation of the sources of error in microbiological assay and helps analysts choose efficient assay designs that will minimize those sources of error. Beginning with a review of the theoretical basis for the quantitative aspects, the author discusses microbiological assay as a branch of pharmaceutical analysis and distinguishes it from biological assay in general. He draws attention to the microbiological aspects that may not be so obvious to the chemical analyst and to the analytical aspects that may not be so obvious to the microbiologist. The book contains detailed evaluations of assays that illustrate typical experimental designs and addresses how to present a realistic assessment of the best potency estimate from a series of assays. Although there are other valuable books available in this area, they do not address Table of ContentsMicrobiological Assay in Perspective. The Agar Diffusion Assay - Its Quantitative Basis. The Theory and Practice of Tube Assays for Growth Promoting Substances. The Theory and Practice of Tube Assays for Growth Inhibiting Substances. What Do We Want of an Assay? How Do We Attain Our Goal? General Practical Aspects of Microbiological Assays. Standard Reference Materials. Parallel Lines Assays - Some Designs and Their Evaluation. Slope Ratio Assays, Some Designs and Their Evaluation. Choice of Experimental Design. Concluding Thoughts.

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Book SynopsisDetails how advances and demands for safety and efficacy have changed the process by which drugs are developed and approved. This work examines critical considerations for trials conducted during each phase of clinical development. It explores early pre-clinical evaluations of pharmacological activity and safety.Trade Review“This book is useful because it consolidates information from preclinical and clinical fields and also adds the perspective of regulatory agencies in bringing drugs to market…definitely is more ambitious than the previous edition.” —Alan Poisner, M.D., Doody’s Book Review Service “This volume provides an overview of current procedures and major issues involved in drug and biopharmaceutical development. The book examines critical biochemical and pharmaceutical considerations for trials conducted during each phase of clinical development. It also reports information related to early pre-clinical evaluations of pharmacological activities and safety before proceeding with the initiation of clinical trials. … Practical and informative, this step-by-step guide includes information on all four phases of clinical trials prior to licensure and covers the design of post-marketing studies. The editors examine how recent advances and increased demand for safer and more effective drugs have changed the process by which drugs are developed and approved.” — In Anticancer Research, Vol. 26, 2006Table of ContentsPreparation for Clinical Trials. Regulatory Organization and Decision Making. Evaluation and Quality Assurance of Drugs and Biopharmaceuticals. Future Perspectives in Drug Development

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Book SynopsisCarefully crafted to provide tightly focused and authoritative information, the Directory of Therapeutic Enzymes covers all approved therapeutic enzymes currently used in medicine. Written mainly by industry experts, the book includes information sourced directly from the company that developed or manufactured the product. It explores major development issues, from manufacturing and marketing to delivery of the finished product.Chapter 1 reviews applied enzymology while chapter 2 delineates theory and applications. Between them, the first two chapters set the appropriate backdrop for the remaining chapters, which focus on actual enzyme products that have gained regulatory approval for general medical use. The chapter authors discuss the biochemistry of the enzymes, the reactions they catalyze, how they are produced or manufactured, and their medical applications. The book highlights the many applications of approved therapeutic enzymes, including use in the treatment of blood-clotting disorders, certain cancers, and a variety of genetic disorders. Illustrated with tables and figures that support the text, the book is a single source of in-depth technical information.Table of ContentsApplied Enzymology, An Introduction. Enzyme Engineering. Tissue Plasminogen Activator (tPA). Urokinase. (Activated) Protein C. Ancrod. Nuclease (Dnase). Glucocerebrosidase. L-Galactosidase. Urate Oxidase. Asparaginase. Factor Ixa. Superoxide Dismutase. Debriding and Anti-Inflammatory Agents. Enzymes as Digestive Aids.

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Book SynopsisThis book provides a broad base of knowledge of G-protein-coupled receptors. Useful at both the university and industrial levels, this book is of particular interest to those who are developing therapeutic approaches to diseases using drugs that influence receptor activation.Table of ContentsScreening of Ligands for GPCRs. Screening of Endogenous Ligands for Orphan GPCRs. Screening of Ligands for Human GPCRs by the Use of Receptor-Ga Fusion Proteins. Screening and Identification of Ghrelin, an Endogenous Ligand for the Growth-Hormone-Secretagogue Receptor. Ligand Screening of Olfactory Receptors. Functions and Regulation of GPCRs. Generation and Phenotypical Analysis of Muscarinic Acetylcholine Receptor Knockout Mice. Systematic Mutagenesis of M1 Muscarinic Acetylcholine Receptors. Analysis of the Regulation of Muscarinic Acetylcholine Receptors. Single-Molecule Analysis of Chemotactic Signaling Mediated by cAMP Receptor on Living Cells. Oligomerization of G Protein-Coupled Purinergic Receptors. Tertiary Structure of GPCRs and their Ligands. Methods and Results in X-ray Crystallography of Bovine Rhodopsin. Determination of Steric Structure of Muscarinic Ligands Bound to Muscarinic Acetylcholine Receptors: Approaches by TRNOE (Transferred Nuclear Overhauser Effect). Modeling of G Protein-Coupled Receptors for Drug Design.

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Book SynopsisMany specialists are not familiar with both drug delivery and the molecular biology of DNA vectors. Liposomes in Gene Delivery covers both-molecular biologists will gain a basic knowledge of lipids, liposomes, and other gene delivery vehicles; lipid and drug delivery scientists will better understand DNA, molecular biology, and DNA manipulation. Topics include an introduction to nucleic acids, a theoretical description of DNA, recombinant technology, lipids and liposomes, stability and interaction properties of lipids and liposomes, complexation of lipids and liposomes with DNA plasmids, gene expression of genosomes in various models, structure-activity relationships, and transfection models. This is an excellent introductory text for graduate students, scientists, and researchers in molecular and cell biology, genetics, biochemistry, physical chemistry, colloid science, pharmacology, molecular science, and medicine.Table of Contents1. Introduction -- Additional Reading -- 2. Gene Therapy -- Strategies in Gene Delivery -- Disease Applications of Gene Therapy -- Genetic Diseases -- Cancer -- Infectious Diseases -- Neurological Diseases -- Cardiovascular Diseases -- Other Diseases -- Summary -- Additional Reading -- 3. Nucleic Acids -- DNA Structure and Conformation -- DNA Stability and Interactions -- Theoretical Description of DNA -- Statistical Thermodynamic Models -- and Molecular Dynamics -- Polyelectrolyte Models -- DNA Condensation -- Recombinant DNA Technology -- DNA Plasmid Preparation and Purification -- Genetic Engineering -- Production of Materials and Goods -- Transgenic Animals -- Summary -- Additional Reading -- 4. Gene Expression -- Promoters and Enhancers -- Introns and poly A Tails -- Complementary DNA -- Cytoplasmic Gene Expression -- Reporter Genes -- Vectors -- Summary -- Additional Reading -- 5. Gene Delivery -- Naked DNA -- Viral Systems -- Nonviral Delivery Systems -- Polycations, Polypeptides, and Polymers -- Polyelectrolytes -- Cationic Liposomes and Other Colloidal Particles -- Conventional Liposomes -- Targeted Systems -- Targeted Liposomes -- Minichromosomes -- Transkaryotic Therapy -- RNA Delivery -- Summary -- Additional Reading -- 6. Liposomes -- Lipids and Liposome Composition -- Cationic Lipids -- Electrostatic Properties of Charged Lipids and Liposomes -- Cationic Liposomes -- Liposome Preparation Methods -- Hydration of Lipids -- Sonication -- Extrusion -- Homogenization -- Mechanism of Vesicle Formation -- Liposome Stability -- Colloidal Stability of Liposomes: The DLVO Theory -- Characterization and Quality Control -- Interactions of Liposomes with Cells and In Vivo -- Toxicity and Safety of Cationic Liposomes -- Liposomes and Cell Membranes -- Liposome Applications -- Drug Delivery -- Summary -- Additional Reading -- 7. Genosomes (DNA—Lipid Complexes) -- Reactivity and Stability -- Electrostatics of DNA-Liposome Interactions -- Structure of Cationic Lipid-DNA Complexes -- Characterization -- Pharmacokinetics and Biodistribution -- Toxicity -- Summary -- Additional Reading -- 8. Genosomes for Gene Delivery and Transfection -- Expression In Vitro -- Gene Transfection and Expression In Vivo -- Parenteral Applications of Genosomes -- Pulmonary Delivery -- Other Delivery Routes -- Genosome Administration into Humans -- Summary -- Additional Reading -- 9. Structure-Activity Relationships -- Structure-Activity Relationships -- Structure-Activity Relationships of -- Cationic Lipids on the Molecular Level -- Cholesteroyl-Anchored Cationic Lipids -- Diacyl Chain Cationic Lipids -- Structure-Activity Relationships on the Colloidal Level -- Summary -- Additional Reading -- 10. Mechanism of Transfection -- Transfection In Vitro -- Transfection In Vivo -- Factors and Steps That Determine Transfection -- Summary -- Additional Reading -- 11. Other Carrier Systems and Artificial Virus -- Polyelectrolytes Combination Complexes -- Polyelectrolyes -- Combination Complexes -- Summary -- Additional Reading -- 12. Liposomes in the Delivery of Antisense Oligonucleotides -- Introduction -- Antisense Oligonucleotides: -- Structure and Mechanism of Action -- Liposomes for the Delivery of Antisense Oligonucleotides -- Overview of Some of the Results -- Use of Anionic/Neutral Liposomes for Delivery -- Use of Cationic Liposomes in Oligonucleotide Delivery -- Ribozymes -- Delivery of Proteins -- Summary -- Additional Reading -- 13. Perspectives and Conclusion -- Cationic Liposomes -- Anionic Liposomes -- Sterically Stabilized Liposomes -- Summary -- Conclusion and Afterword -- Additional Reading -- References -- Appendix A: Some Fundamental Constants -- Appendix B: Periodic System of Elements -- Appendix C: A Short Tutorial on Different Units -- Appendix D: Geometric Parameters of Lipids and Nucleic Acids -- Appendix E: Abbreviations -- Appendix F: Glossary -- Index.

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Book SynopsisThe ballooning body of research devoted to hyaluronan (HA) reflects its enormous potential for various medical applications. There have been many successes of varying degrees in the development of medical products based on HA, but also some setbacks. While there is obviously ample information available on the chemistry and various properties of this macromolecule, Practical Aspects of Hyaluronan Based Medical Products is the first book devoted to systematically applying this knowledge to product development.Based on the author''s extensive experience working with HA, this book explores in detail the chemistry, composition, formulation, testing, safety, effectiveness, quality control, and regulatory approval of HA medical products. It begins with a survey of the historical development and recent products based on hyaluronan. Subsequent chapters detail the rheological properties of the molecule and explore the chemical principles and methods forming the technical basis of productTable of ContentsOverview. Chemistry. Rheological Properties of Hyaluronan as Related to Its Structure, Size, and Concentration. Standards, Tests, and Analytical Methods. Safety of Hyaluronan-Based Medical Products in Their Indicated Applications. Clinical Performance, Mechanism of Action, and Product Characteristics. Index.

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Book SynopsisThere is an estimated 2.5 million epileptics in the US and perhaps some 40 million worldwide. As research has become increasingly molecular in scope, fewer scientists are trained in the US on basic, integrated epilepsy techniques. One frustration in neuroscience today is the application of state-of-the-art molecular biology techniques to inappropriate animal models of epilepsy - frequently resulting in inconclusive results. Epilepsy research will be increasingly undertaken by scientists well-trained in reductionist methodology, but who may be unfamiliar with integrated, whole-animal techniques. This situation appears even more difficult considering there has been no updated textbook on experimental models of epilepsy over the last twenty years - until now.Neuropharmacology Methods in Epilepsy Research describes fundamental methodologies and procedures in this field, representing the only detailed text concerning experimental models of epilepsy published in the last 20 years. This gTrade Review"A first-rate method book...[The authors] are highly skilled scientists with many years of experience in epilepsy."- Mannfred A. Hollinger, Department of Medical Pharmacology and Toxicology, School of Medicine, University of California, DavisTable of ContentsElectroshock, Chemoconvulsants, The Kindling Model of Temporal Lobe Epilepsy, Rapid Kindling: Behavioral and Electrographic, Experimental Models of Status Epilepticus, Audiogenic Seizures in Mice and Rats, Models of Focal Epilepsy in Rodents, Evaluation of Associated Behavioral and Cognitive Deficits in Anticonvulsant Drug Testing, Gene Targeting Models of Epilepsy: Technical and Analytical Considerations, The Hippocampal Slice Preparation, Microdialysis Techniques for Epilepsy Research, Methodologies for Determining Rhythmic Expression of Seizures.

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Book SynopsisPost-Translational Modifications of Proteins discusses several important topics of interest to researchers and students in protein chemistry and biochemistry, including the occurrence and function of hydroxylated residues and the three enzymes required for their formation; the damaging effects of reactions between sugars and proteins; ADP-riboosylation of proteins outside the nucleus; and Monod, Wyman, and Changeux's concerted model for allosteric control of enzyme activity exemplified by studies on glycogen phosphorylase. The application of Fast Atom Bombardment Mass Spectometry (FAB-MS) to studies on the structure and biosynthesis of various oligosaccharide moieties in protein is examined, and the understanding of the structural diversity and function of glycoprotein oligosaccharides is discussed in this volume.Table of ContentsHydroxylation of Proline and Lysine Residues in Collagens and Other Animal and Plant Proteins (K.I. Kivirikko, R. Myllyla and T. Pihlajaniemi). Advanced Glycosylation Endproducts (R. Bucala, H. Vlassara and A. Cerami). Rabbit Muscle Glycogen Phosphorylase b. The Structural Basis of Activation and Catalysis (N.G. Oikonomakos, K.R. Acharya and L.N. Johnson). Mono-ADP-Ribosylation of Proteins (S. van Heyningen). Glycan Structures in Glycoproteins and Their Analysis by Fast Atom Bombardment Mass Spectrometry (A. Dell, R.A. McDowell and M.E. Rogers). Glycoproteins of Mammalian and Avian Cells (F.W. Hemming).FEATURES:

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Book SynopsisThe Amphipathic Helix is a comprehensive volume discussing amphipathic helices in systems as diverse as serum lipoproteins, lung surfactant, cytotoxic peptides, ion channels, mitochondrial targeting, peptide hormones, G proteins, T-cell recognition, DNA binding proteins, and antifreeze proteins. The book also includes general introductory material that defines amphipathic helices, discusses methods to identify amphipathic helical segments from the amino acid sequence of a protein, illustrates how amphipathic helices can be used in the de novo design of peptide and protein structures, and describes how these helices stabilize protein structures. There is also a section on techniques to determine helix orientation in a membrane environment using polarized attenuated total reflection infrared spectroscopy or solid state NMR spectroscopy. Recent developments on all these topics have been discussed by leading experts in this reference for researchers and students in biochemistry, biophysicsTable of ContentsIntroduction and Overview (R.M. Epand). Design of Amphipathic Helices: Computational Techniques to Predict Amphipathic Helical Segments (I.E. Auger). Amphipathic Helices in Designed Peptide Structures (J.M. Stewart). The Role of Amphipathic Helices in Stabilizing Peptide and Protein Structure (C.T. Mant, N.E. Zhou, and R.S. Hodges). Experimental Methods for Studying Amphipathic Helices in Membranes: Polarized Attenuated Total Reflection Infrared Spectroscopy as a Tool to Investigate the Structure and Orientation of Amphipathic Peptides in a Lipid Bilayer (E. Goormaghtigh, V. Cabiaux, and J.-M. Ruysschaert). NMR Spectroscopy of Amphipathic Helical Peptides in Membrane Environments (S.J. Opella, J. Gesell, and B. Bechinger). Biological Roles for the Interactions of Amphipathic Helices with Lipids: An Atlas of the Amphipathic Helical Domains of the Human Exchangeable Plasma Apolipoproteins (G.M. Anantharamaiah, M.K. Jones, and J.P. Segrest). Amphipathic Helical Segments in Lung Surfactant Proteins (A.J. Waring, L.M. Gordon, H.W. Taeusch, and R. Bruni). The Amphipathic Helix in Cytotoxic Peptides (I. Cornut, E. Thiaudière, and J. Dufourcq). Amphipathic Helices and Ion Channels (J. Tomich). Other Biological Roles for Amphipathic Helices in Membrane-Related Phenomenon: The Amphipathic Helix in Mitochondrial Targeting Sequences (D. Roise). Amphiphilic Helices in Neuropeptides (J.W. Taylor). Activation of G Proteins by Membrane Receptors and Peptides. Putative Role for Amphipathic Helices (M. Mousli and Y. Landry). The Amphipathic Helix as a Structural Feature Involved in T-Cell Recognition (J.L. Cornette, H. Margalit, C. DeLisi, and J.A. Berzofsky). Other Biological Roles of Amphipathic Helices: Amphipathic Helices in Proteins that Bind to DNA: The bZIP and bHLH-Zip DNA Binding Motifs (C.R. Vinson). Protein-Ice Interactions: Antifreeze Proteins (D.S.C. Yang).

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Book SynopsisSince the discovery of endothelin, major advances have been made in understanding the molecular structure and function of the endothelin receptors. At least two subtypes of receptors, designated ETA and ETB, have been identified through biochemical and pharmacological techniques. These subtypes are cloned and expressed and additional subtypes appear to exist. The biochemical events involved in the signal transduction processes that ultimately activate the cellular machinery involved in the end-organ responses are presented, as are the mechanisms by which the receptors recognize specific and different G-proteins. Functions mediated by the receptors at the cellular, tissue and, organ level are reviewed in detail, as well as the roles that they may play a part in the physiologic and pathophysiologic processes in animals and in humans.This book is unique in its breadth of scope. The most recent and important advances, from the intracellular level of the nucleus to the functional effTrade Review"This book is recommended as an addition to the libraries of institutions and individual researchers actively studying the physiological and/or pathophysicological role of endothelin."- J. Med. Chem., 1996, 39(3)Table of ContentsIntroduction: Endothelin Receptors, E.H. Ohlstein and R.R. Ruffolo, Jr.Endothelin Receptor Subclassification, E.H. Ohlstein, P. Nambi, and R.R. Ruffolo, Jr.Molecular Biology of Endothelin Receptors, D.J. Bergsma, N. Elshourbagy, and C. Kumar Signal Transduction Processes Involved in Endothelin-Mediated Responses, P. Nambi, C. Kumar, and E.H. OhlsteinEndothelin Receptor Antagonists, J.D. Elliott, M.A. Lago, and C.E. PeishoffFunctions Mediated by Peripheral Endothelin Receptors, E.H. Ohlstein, S. Douglas, D.P. Brooks, D.W.P. Hay, G.Z. Feuerstein, and R.R. Ruffolo, Jr.Endothelin in the Central Nervous System, R.N. Willette, G.Z. Feuerstein, and F.C. BaroneThe Role of Endothelin in Human Disease: Implications and Potential Therapeutic Intervention, D.K. Jorkasky, D.W.P. Hay, and M.I. FreedIndex

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Book SynopsisCritical Analysis of Monoclonal Antibody Therapy in Transplantation provides a critical analysis of monoclonal antibody therapies in transplantation. The book presents diverse approaches to monoclonal antibody therapy in transplantation and addresses some of the serious obstacles that remain both in understanding these mechanisms and in successfully applying them in clinical situations.The background and rationale for OKT3 therapy are examined and an extensive clinical experience with OKT3 induction therapy in cardiac transplantation is reviewed. The book also examines the background and rationale for the use of anti-TcR (??), anti-IL-2R, and anti-LFA-1 monoclonal antibodies in clinical transplantations. Other topics include the use of monclonal antibodies to CD4 and CD8 for the induction of adult transplantation tolerance in rodents and the possibilities for applying anti-idiotypical strategies that have proven useful in autoimmunity models to transplant recipients.Researchers and basic scientists involved in this field will find the book a fascinating and useful resource for their investigations.Table of ContentsAnti-CD3-Mediated Immunotherapy: A Murine Model. OKT3 in Allogenic Transplantation: Clinical Efficacy, Mode of Action, and Side Effects. The Use of OKT3 for Induction Therapy in Cardiac Transplantation. Anti-IL-2 Receptor and Anti-LFA-1 Monoclonal Antibodies in Transplantation: Rationale and Nantes Clinical Experience. Transplantation Tolerance with Monoclonal Antibodies. Anti-CD4-Mediated Transplantation Tolerance: Mechanisms and Memory. Prospects for Anti-Idiotype Therapy in Transplantation.

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Book SynopsisThis book provides valuable information for investigators interested in the signaling and regulatory functions of adenosine and the adenine nucleotides. Topics covered in this comprehensive volume include the historical development of research on adenosine and adenosine triphosphate; various aspects of the formation, metabolism, release, transport, and receptors for endogenous adenosine and the adenosine triphosphate; functions of purines at the cellular level; the role of adenosine in the regulation of flow in different vascular beds; and angiogenesis. The book also addresses the purinergic regulation of the cardiac, renal, gastro-intestinal, and central nervous system, as well as potential therapeutic avenues for purine use. The book will be valuable to physiologists, pharmacologists, and other basic and clinical scientists interested in updating their knowledge of the expanding biological roles of these substances.Table of ContentsINTRODUCTION. Historical Perspectives-Adenosine (D.J. Cushing and S.J. Mustafa). Historical Perspectives-ATP (D. Satchell). PURINE RECEPTORS, METABOLISM, RELEASE, AND TRANSPORT. Adenosine Receptors: Ligand-Binding Studies (U. Schwabe). Adenosine Receptors, Adenylate Cyclase; Relationships to Pharmacological Actions of Adenosine (R.D. Green). Formation and Metabolism of Adenosine and Adenine Nucleotides in Cardiac Tissue (J. Schrader). Adenosine Deaminase Regulation of Purine Actions (J.D. Geiger, R.A. Padua, and J.I. Nagy). Nucleoside Transport in Cells: Kinetics and Inhibitor Effects (L. Hertz). Adenosine and Adenine Nucleotides in Tissues and Perfusates (T.D. White and K. Hoehn). FUNCTIONS OF PURINES AT THE CELLULAR LEVEL. Adenosine, Adenine Nucleotides and Platelet Function (N.J. Cusack and S.M.O. Hourani). Purines and Inflammation: Neutrophils Possess P1 and P2 Purine Receptors (B.N. Cronstein). Adenosine and Immune System Function (T.S. Priebe and J.A. Nelson). Purinergic Regulation of Transmitter Release (J.A. Ribeiro). ADENOSINE AND BLOOD FLOW IN VASCULAR BEDS. Effect of Adenosine on the Coronary Circulation (M.G. Collis). Purinergic Control of Skeletal Muscle Blood Flow (M.W. Gorman, S.S. Kelley, L. Kaiser, and H.V. Sparks). Adenosine and the Regulation of Cerebral Blood Flow (D.G.L. Van Wylen, V.M. Sciotti, and H.R. Winn). Adenosine and Blood Flow Through the Gastrointestinal Tract (K.G. Proctor and B. Langkamp-Henken). Adenosine-Mediated Regulation of Hepatic Blood Flow (W.E. Lautt). Effects of Adenosine and Adenine Nucleotides on the Pulmonary Circulation (A. Hyman, B. Cai, C. Feng, Q. Hao, and H. Lippton). The Role of Adenosine in Angiogenesis (C.J. Meininger and H.J. Granger). ACTIONS OF ADENOSINE ON BODY SYSTEMS. Influence of Adenosine on Cardiac Activity (M.G. Collis). Adenosine Receptor Activation and Renal Function (W.G. Spielman). Purinergic Regulation of Gastrointestinal Motility and Secretion (M.A. Cook). Effects of Adenosine Infusion on the Cons

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Book SynopsisOsteoporosis, a growing epidemic among women in North America, Europe, and Japan, is a painful, costly disease that has presented a treatment challenge to healthcare professionals. Until recently, therapies have focused on agents that slow bone resorption, and have had only limited success at increasing bone mass.However, exciting new developments are on the verge of changing the treatment of this debilitating disorder. Two anabolic agents, the parathyroid hormone (PTH) and the fluoride ion, show tremendous promise as tools for building and retaining bone - with no adverse side effects. Anabolic Treatments for Osteoporosis is a comprehensive account of the latest studies that have been carried out on these two agents, and a thorough assessment of their prospects as osteoporosis therapeutics. This unique book combines basic science and up-to-date clinical data to present a complete picture of this breakthrough in the treatment of a globally significant health issue.Table of ContentsOsteoporoses: Their Nature and Therapeutic Targets. Osteoporosis - Mechanisms and Models. PTH: Skeletal Effects in the Ovariectomized Rat Model for Postmenopausal Bone Loss. Parathyroid Hormone: The Clinical Experience and Prospects. Adenylyl Cyclase-Activating Anabolic Agents: Parathyroid Hormone and Prostaglandins E. Bone Formation May Be Uncoupled from Resorption, as Demonstrated by a New Class of hPTHrP-(1-34) Analogues in Both Rapid and Slow Turnover Models of Osteopenia. Commercial Exploitation of Parathyroid Hormone Therapy for the Treatment of Postmenopausal Osteoporosis. The Insulin-Like Growth Factors: Potential Anabolic Agents for the Skeleton. Osteogenic Actions of Fluoride: Its Therapeutic Use for Established Osteoporosis. Index. NTI/Sales Copy

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Book SynopsisWritten specifically for pharmacy students, this book explains basic statistics. It contains chapters on basic concepts such as types of data, graphical representation of data, distribution and standard deviation. More advanced statistical techniques, such as ANOVA, are also discussed.Trade Review'This book is a welcome addition to the Pharmacy library...an undoubted strength of the book is its clarity in presentation...the book is highly recommended to any person interested in quantitative aspects of pharmacy...' Prof. Mike Roberts, the Department of Medicine, Department of Practice and Policy, Princess Alexandra Hospital, The University of Queensland, Australia, Journal of Pharmacy and Pharmacology, 1 May 2003 -- Mike Roberts * Journal of Pharmacy and Pharmacology *'Pharmaceutical Statistics is well thought out and well written, with a good layout that does not get bogged down with overly complex explanations.' Henry Skupek, Program Support Coordinator, Australian College of Pharmacy Practice, Canberra, Australian Pharmacist, 1 Feb 2003 -- Henry Skupek * Australian Pharmacist *'...the book is a useful addition to the range of books available on pharmaceutical statistics.' Alain Li Wan Po, The Pharmaceutical Journal, 7 June 2003 -- Alain Li Wan Po * The Pharmaceutical Journal *

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Book SynopsisThis work gives an introduction to all aspects of drug use in renal failure.Introduction to Renal Therapeutics is an introduction to all aspects of drug use in renal failure. Covering various diseases affecting the kidneys, each chapter discusses the disease process and treatment. It also addresses the role of the pharmacist in patient care. Case studies and questions and answers are included at the end of each chapter.Written by members of the UK Renal Pharmacy Group, this book will be of particular interest to anyone new to, or planning a career in, renal pharmacy. It will also be of interest to nonspecialists who deal with renal patients and to pharmacy students, and to any healthcare professional with an interest in renal medicine.Trade Review'The book is organized so that any topic can be referenced easily and individual chapters are structured so that information is provided in a logical and clear format. This is a useful reference for pharmacists working with renally impaired patients. It outlines some of the major challenges encountered in clinical practice when treating these patients. The chapters are organized nicely with topic headings and tables highlighting key concepts, and succeeds in capturing clinically pertinent topics in renal medicine today.'Melissa M. Ranieri, BS, PharmD (Temple University School of Pharmacy) Doody Enterprises, Inc. March 2008 -- Melissa M. Ranieri * Doody's Notes *'The text offers a good overview of the issues pertinent to chronic kidney disease. Introduction to Renal Therapeutics provides a broad overview of the diseases and complications commonly associated with chronic kidney diseases and will be of interest to pharmacists and pharmacy students not familiar with nephrology.'Marianna Leung, BSc Pharm, PharmD CHJP Vol. 61, No. 4 July- August 2008 -- Marianna Leung * CHJP *'This book will be of value to anyone interested in expanding his or her knowledge about drug therapy for the renally impaired patient. The devotion of separate chapters to complications such as renal bone disease encourages the reader to fully explore the nuances of these conditions and their drug therapy.'Hillary Wall Grillo PharmD, The Annals of Pharmacotherapy Volume 42 July/ August 2008 -- Hillary Wall Grillo * The Annals of Pharmacotherapy *Table of Contents1. Introduction; 2. Laboratory Tests and Investigations; 3. Acute Renal Failure; 4. Chronic Kidney Disease; 5. Renal Anaemia; 6. Renal Bone Disease; 7. Hypertension / Hyperlipidaemia; 8. Renal Replacement Therapy; 9. Renal Transplantation; 10. Drug Dosing in Patients with Renal Impairment; 11. Drug Induced Kidney Failure; 12. Autoimmune Kidney Disease; 13. Paediatric Kidney Disease; 14. Renal Pharmacy in Critical Care; 15. Pain Control in Renal Impairment; 16. Diabetes Management in Kidney Disease; 17. Myeloma and Kidney Disease; 18. Palliative care; 19. Dietary Management of Kidney Disease; 20. Travelling and Vaccines.

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