Description
Book SynopsisExploring the role of Immunoglobulin-E (IgE) in human disease, this reference summarizes current research on the mechanisms and utilization of anti-IgE therapeutics in the treatment of IgE-mediated allergic disease, inflammation, and asthma-discussing the structural composition of high- and low-affinity IgE receptors, the airway cells that express these receptors, and the functional activity of IgE-FceRI and IgE-FceRII interactions for improved control and management of allergic disorders.
Compiles previously unpublished data from the first extensive scientific investigations of Xolair!
IgE and Anti-IgE Therapy in Asthma and Allergic Disease
reviews studies on the distribution of serum IgE levels of normal and asthmatic populations in developed regions of the world such as the United States, Canada, Scandinavia, New Zealand, and Europe
offers novel methods for the design and formulation of monoclonal antibodies
discusses the use of allerge
Table of Contents
Introduction
James D. Reimann, Sharon Safrin, and Robert B. Fick, Jr.
Understanding the Binding of IgE to Its High-Affinity Receptor and to an Anti-IgE Antibody
Leonard G. Presta and Robert L. Shields
Mediator Release from Basophils and Mast Cells and Its Relationship to FceRI Expression and IgE-Suppressing Therapies
Donald W. MacGlashan, Jr., John T. Schroeder, Lawrence M. Lichtenstein, Sarbjit S. Saini, and Bruce S. Bochner
Expression of IgE Receptors on Eosinophils
David Dombrowicz, André Capron, and Monique Capron
Eosinophil IgE Receptors: Controversy and Consensus
Hirohito Kita and Cheryl R. Adolphson
Murine Models of Asthma: Caveats and Conclusions on the Contribution of IgE and Mast Cells to Allergic Inflammation, Airway Hyperresponsiveness, and Airflow Obstruction
Jeffrey S. Tepper and Daniel B. Tumas
Role of IgE in Asthma: Pathogenesis and Novel Therapeutic Strategies
James Laurence Lordan, Stephen T. Holgate, and Ian Sayers
IgE-Mediated Response to Allergen in the Bronchoprovocation Laboratory
Louis-Philippe Boulet and Donald W. Cockcroft
Pathophysiology of the Airway Response to Inhaled Allergen in Asthmatic Subjects: Role of IgE
John V. Fahy
Efficacy and Safety of Xolair Anti-IgE Monoclonal Antibody in Adult Asthmatics
Robert B. Fick, Jr., and W. James Metzger
The Role of IgE in Pediatric Asthma
Henry Milgrom and Charles Johnson
Anti-inflammatory Activities of Omalizumab (Xolair), a Recombinant Humanized Monoclonal Antibody Binding IgE
Robert B. Fick, Jr.
Pulmonary Delivery of Anti-IgE: Rationale for Topical Delivery to the Airway
Theresa D. Sweeney, Melinda Marian, Jane Ruppel, and Jeanine L. Bussiere
Treatment of Seasonal Allergic Rhinitis
Thomas B. Casale and Patricia W. Rohane
Anti-IgE and Allergic Skin Diseases
Michaël F. Hofer and Donald Y. M. Leung
Role of IgE and Food Allergens
Ricki M. Helm and A. Wesley Burks
Role of IgE in Allergic Bronchopulmonary Aspergillosis
Priscilla S. A. Sarinas and Rajinder K. Chitkara
IgE and Its Role in Parasitic Helminth Infection: Implications for Anti-IgE-Based Therapies
Philip J. Cooper and Thomas B. Nutman
The Rise of Antibodies as Therapeutics
Maureen P. Quan and Paul Carter
Author Index
