Description
Book SynopsisA user-friendly guide for the evaluation of microbiological assays, Microbiological Assay for Pharmaceutical Analysis: A Rational Approach provides a lucid explanation of the sources of error in microbiological assay and helps analysts choose efficient assay designs that will minimize those sources of error. Beginning with a review of the theoretical basis for the quantitative aspects, the author discusses microbiological assay as a branch of pharmaceutical analysis and distinguishes it from biological assay in general. He draws attention to the microbiological aspects that may not be so obvious to the chemical analyst and to the analytical aspects that may not be so obvious to the microbiologist.
The book contains detailed evaluations of assays that illustrate typical experimental designs and addresses how to present a realistic assessment of the best potency estimate from a series of assays. Although there are other valuable books available in this area, they do not address
Table of ContentsMicrobiological Assay in Perspective. The Agar Diffusion Assay - Its Quantitative Basis. The Theory and Practice of Tube Assays for Growth Promoting Substances. The Theory and Practice of Tube Assays for Growth Inhibiting Substances. What Do We Want of an Assay? How Do We Attain Our Goal? General Practical Aspects of Microbiological Assays. Standard Reference Materials. Parallel Lines Assays - Some Designs and Their Evaluation. Slope Ratio Assays, Some Designs and Their Evaluation. Choice of Experimental Design. Concluding Thoughts.
